text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the transformed rat cells were fused to permissive chick cells and the rescued virus was shown to transform both chick embryo fibroblasts and the appropriate haemopoietic cell type in chick bone marrow cultures . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} |
in order to investigate evidence for increased psychopathology as a function of complex partial seizures ( temporal lobe epilepsy in the old nomenclature ) , three groups of epilepsy patients differing in seizure type were compared on the mmpi . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
121,
129
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
205,
212
]
} |
by use of a horseradish peroxidase-conjugated indirect antibody procedure , however , differences were detected in the cross-reactivities of the antisera to rat nfps , separated by page and electrophoretically transferred to nitrocellulose membranes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
145,
153
]
} |
the uptake of tryptophan is stimulated by a membrane potential ( interior negative ) as demonstrated by the effects of the ionophores valinomycin and carbonyl cyanide m-chlorophenylhydrazone and anions with different permeabilities . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
159,
166
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
195,
201
]
} |
specific radioactivities of 14c- or 3h-labeled phenylalanine , tyrosine , leucine , isoleucine , and valine were determined in plasma and in small brain tissue samples for free amino acids , aminoacyl-trnas , and proteins . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
177,
188
]
} | {
"id": "C0035714",
"name": "aminoacyl-trnas",
"pos": [
191,
206
]
} |
although aminoacylation of trnas was found to proceed to a comparable degree for neutral amino acids in all regions investigated , the specific radioactivity of amino acids attached to trnas differed substantially from that in the free amino acid pool , especially for leucine and valine . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
81,
100
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
236,
246
]
} |
staining was blocked by diisopropyl-fluorophosphate , which inhibits both pseudocholinesterase and acetylcholinesterase , but was not blocked by tetraisopropylpyrophosphoramide , a specific pseudocholinesterase inhibitor . | NA | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
74,
94
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
99,
119
]
} |
biological availability of egg yolk iron and effect of egg yolk on absorption of iron from the reference salt , ferrous sulfate , were evaluated in hemoglobin repletion assays with anemic rats . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
36,
40
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
112,
127
]
} |
rbv of egg iron was equivalent to ferrous sulfate iron in diets containing 1 g ascorbic acid per kilogram of diet . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
11,
15
]
} | {
"id": "C0060282",
"name": "ferrous",
"pos": [
34,
41
]
} |
total cobalamin and methylcobalamin levels were determined in tissues of male f344 rats fed a complete , amino acid-defined diet or a diet deficient in methionine , choline and/or cyanocobalamin . | NA | {
"id": "C0065844",
"name": "levels",
"pos": [
36,
42
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
180,
194
]
} |
brain tryptophan levels correlated better with plasma trp : neutral amino acid ratios ( r = 0.83 ) than with plasma tryptophan itself ( r = 0.63 ) suggesting that the small changes observed in plasma amino acid profiles were responsible for differences in the brain tryptophan concentrations among the l-tryptophan and t... | NA | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
60,
78
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
200,
210
]
} |
functional changes of am were determined by measuring phagocytosis of latex beads , yeast cells or opsonized sheep red blood cells ( srbc ) and the ability to respond to a macrophage-activating factor ( maf ) such as lymphokines . | NA | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
172,
200
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
217,
228
]
} |
brain tryptophan concentrations and a brain amino acid ratio ( glycine + serine + glutamine + taurine : leucine + isoleucine + valine + methionine ) were not related to food intake in zd rats in contrast to zinc-adequate controls . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
44,
54
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
63,
70
]
} |
tissue contents of free and lipid-bound myo-inositol as well as the activities of l-myo-inositol-l-phosphate synthase ( ec 5.5.1.4 ) and phosphatase ( ec 3.1.3.25 ) , and myo-inositol oxygenase ( ec 1.13.99.1 ) were determined in male and female gerbils under various conditions . | NA | {
"id": "C0021547",
"name": "myo-inositol",
"pos": [
40,
52
]
} | {
"id": "C0021554",
"name": "myo-inositol",
"pos": [
171,
183
]
} |
weanling rats were fed varying levels of cellulose , hemicellulose , lignin and pectin with and without t-2 toxin ( 3 micrograms/g feed ) for 2 weeks . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
41,
50
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
69,
75
]
} |
plasma cholesterol , vldl ( very low density lipoprotein ) and hdl ( high-density lipoprotein ) cholesterol , hepatic cholesterol synthesis , liver cholesterol and lipid concentrations were not significantly affected by manganese deficiency . | NA | {
"id": "C0023822",
"name": "high-density lipoprotein",
"pos": [
69,
93
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
148,
159
]
} |
manganese deficiency had no significant effect on hepatic cholesterol and fatty acid synthesis , plasma cholesterol , vldl and hdl cholesterol concentrations , liver lipid and liver cholesterol concentration in either group of rico rats . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
127,
142
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
182,
193
]
} |
the mechanisms of the previously described competitive zinc : iron interaction were explored in healthy human volunteers , using the increment in plasma zinc concentration after an oral dose of 25 mg of zinc as zinc sulfate as the index of zinc absorption . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
55,
59
]
} | {
"id": "C0078794",
"name": "zinc sulfate",
"pos": [
211,
223
]
} |
the gender difference in arachidonate toxicity is apparently not due to differences in sensitivity to thromboxane a2 , as the thromboxane agonist was equally toxic in males and females . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
4,
10
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
179,
184
]
} |
stromal cells grew rapidly to confluence , displayed overgrowth , and had a fibroblastic appearance with an absence of junctional complexes between cells . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
76,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
the effect of the iud on endometrial prostaglandin release was examined by measuring pge and pgf concentrations in uterine tissue and utero-ovarian venous plasma . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
37,
50
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
85,
88
]
} |
we examined the susceptibility of various anaerobes to four beta-lactamase susceptible ( ampicillin , amoxycillin , cyclacillin , and penicillin g ) and two beta-lactamase resistant ( moxalactam , and n-f-thienamycin ) beta-lactam antibiotics and measured beta-lactamase production . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
89,
99
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
102,
113
]
} |
we examined the susceptibility of various anaerobes to four beta-lactamase susceptible ( ampicillin , amoxycillin , cyclacillin , and penicillin g ) and two beta-lactamase resistant ( moxalactam , and n-f-thienamycin ) beta-lactam antibiotics and measured beta-lactamase production . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
89,
99
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
134,
146
]
} |
the initiation codon for the 33k protein lies 606 nucleotides to the right of the ecori restriction site at 70.7 map units and 281 nucleotides to the left of the postulated carboxyterminal codon of the adenovirus 100k protein . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
4,
20
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
189,
194
]
} |
the recombinant dna was propagated and packaged in monkey cells by cotransfection with an early temperature-sensitive mutant ( tsa58 ) dna as helper . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
4,
19
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
135,
138
]
} |
the results indicated that both the initiation and promotion of pancreatic carcinogenesis with bop in hamsters can be inhibited by lack of protein in the diet given for 4 weeks during the early stages of the neoplastic process . | NA | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
75,
89
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
208,
226
]
} |
retrospective assessment of menstrual cycle length in patients with breast cancer , in patients with benign breast disease , and in women without breast disease . | NA | {
"id": "C0016034",
"name": "benign breast disease",
"pos": [
101,
122
]
} | {
"id": "C0006145",
"name": "breast",
"pos": [
146,
152
]
} |
effectors were resistant to anti-theta serum and not removed by adherence to plastic or nylon wool . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
77,
84
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
88,
93
]
} |
the possibility of obtaining a syngeneic antitumor effect by immunization with normal allogeneic cells was investigated by tests of the lytic activity of peritoneal exudate cells ( pec ) of balb/c mice immunized with lymphoid cells of either a single strain or a pool of six different allogeneic strains on the syngeneic... | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
86,
102
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
226,
231
]
} |
histopathologic examination revealed a dose-dependent incidence of primary lung carcinomas of the following types : adenocarcinomas , epidermoid ( squamous cell ) carcinomas , combined epidermoid carcinomas and adenocarcinomas , and mucoepidermoid carcinomas . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
116,
131
]
} | {
"id": "C0206694",
"name": "mucoepidermoid carcinomas",
"pos": [
233,
258
]
} |
five different types of cells were found in the mfhs : fibroblast-like cells , histiocyte-like cells , undifferentiated cells , xanthomatous cells , and multinucleated giant cells ; | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
55,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
174,
179
]
} |
arterial blood samples , obtained before ( control ) , during , and after arterial cross clamping , were analyzed for epinephrine ( e ) and norepinephrine ( ne ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
118,
129
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
140,
154
]
} |
the slower rate of fall in c-peptide antibody levels is likely to be due to the prolonged half-life of circulating exogenous proinsulin in the presence of insulin antibody . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
125,
135
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
155,
162
]
} |
the deterioration in diabetic control may have been due to greater temporal mismatch between insulin needs and insulin availability with pork or human insulin than with beef insulins , and to reduced insulin antibody levels . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
93,
100
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
145,
158
]
} |
the higher doses of bdp were administered in a high-dose beclomethasone aerosol ( bdp 250 ) containing 250 micrograms bdp per metered dose . | NA | {
"id": "C0004905",
"name": "beclomethasone",
"pos": [
57,
71
]
} | {
"id": "C0004906",
"name": "bdp",
"pos": [
118,
121
]
} |
the sugars implicated in dental caries , in decreasing order of cariogenicity , are sucrose , glucose , and fructose ; | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
4,
10
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
84,
91
]
} |
plasma concentrations of fenfluramine and norfenfluramine taken before and 4 weeks after the crossover were similar in both responders and non-responders , but non-responders did not maintain their drug levels for as long as did the responders . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
25,
37
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
42,
57
]
} |
two such methods , otoscopy and tympanometry , were used in two experimental models of otitis media to determine whether there are unique otoscopic and tympanometric characteristics of serous and purulent otitis media . | NA | {
"id": "C0029882",
"name": "otitis media",
"pos": [
87,
99
]
} | {
"id": "C0029888",
"name": "purulent otitis media",
"pos": [
196,
217
]
} |
to elucidate the mechanism by which quercetin enhances the rate of tension development in skinned muscle fibers , effects on calcium release from longitudinal tubule-derived sr ( lsr ) after phosphate-supported calcium uptake were examined . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
125,
132
]
} | {
"id": "C0006711",
"name": "phosphate",
"pos": [
191,
200
]
} |
on week 25 of the baseline period a 1.5 ml blood sample was taken by tail clip for analysis of norepinephrine ( ne ) , epinephrine ( e ) , and plasma renin activity ( pra ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
95,
109
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} |
plasma adrenaline , plasma noradrenaline and serum gastrin concentrations were measured before and after sham feeding in eight patients with duodenal ulcer and in four normal subjects . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} |
the distribution of immunoreactive-dynorphin ( ir-dyn ) in isolated subpopulations of bovine adrenal chromaffin cells was examined and compared with that of adrenaline ( a ) , noradrenaline ( na ) and ir-leucine-enkephalin ( ir-leu-enk ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
157,
167
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
176,
189
]
} |
considering the pharmacokinetic indices and antibiotics studied , ampicillin , cefadroxil ( p.o . ) , cefazolin ( i.v . ) , clindamycin , gentamicin , and tetracycline demonstrated the best pharmacokinetic performances for the penicillin , cephalosporin , macrolide-like , aminoglycoside , and tetracycline groups , resp... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
138,
148
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
273,
287
]
} |
amoxapine is a tricyclic dibenzoxazepine antidepressant that is chemically similar to the antipsychotic agent loxapine . | NA | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
0,
9
]
} | {
"id": "C0024056",
"name": "loxapine",
"pos": [
110,
118
]
} |
normal ventriculography - 1.9 % localized hypokinesia or akinesia - 4.7 % , localized dyskinesia - 6.3 % and diffuse hypokinesia - 11.7 % . | NA | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
86,
96
]
} | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
117,
128
]
} |
in patients with bh the increase of diastolic blood pressure in response to upright posture was associated with an exaggerated increase of plasma na and adrenaline . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
146,
148
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
153,
163
]
} |
the possibility that oxidized gsh reacts with lens protein sulfhydryls was examined by incubating tritiated glutathione disulfide ( [ 3h ] gssg ) with a solution of dialyzed water-soluble bovine lens crystallins . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
30,
33
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
139,
143
]
} |
the ratios of radioactivity incorporated into each crystallin relative to the protein concentration ( cpm/0.d . ratios ) were 0.5 , 6 , 12 and 11 for alpha , beta h , beta l and gamma-crystallins , respectively . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
51,
61
]
} | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
178,
195
]
} |
dialysis of [ 3h ] pssg against increasing concentrations of unlabeled gssg or gsh showed that only gsh could effectively cause the release of radioactivity into the dialysis medium due to the formation of gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
79,
82
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
206,
210
]
} |
the isolates were sensitive to penicillin , ampicillin , ticarcillin , piperacillin , cephalothin , cefoxitin , cefotaxime , cefoperazone , n-formimidoyl-thienamycin , chloramphenicol , clindamycin and erythromycin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
44,
54
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
71,
83
]
} |
studies on snake venom enzymes : part ii -- partial characterization of atpases from russell 's viper ( vipera russelli ) venom & their interaction with potassium gymnemate . | NA | {
"id": "C0037380",
"name": "snake venom",
"pos": [
11,
22
]
} | {
"id": "C0042479",
"name": "venom",
"pos": [
122,
127
]
} |
the differences in sensitivity of renal and hepatic ahh and pcnma activities to the inhibitors may have been due to organ-specific differences in the affinities of the inhibitors for interaction with the active site ( s ) on cytochrome p-450 . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
52,
55
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
225,
241
]
} |
human peripheral blood mononuclear cells , and the same cell population depleted of monocytes , were used to determine whether the absence of monocytes alters the response to isoprinosine . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
56,
60
]
} |
data on substrate specificity , enzyme kinetic constants and specific enzyme inhibitors indicated that , l. acuminata possessed both ache and buche , while , p. globosa had only ache . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
142,
147
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
178,
182
]
} |
[ self-healing childhood histiocytosis x ( illig-fanconi disease ) . comments on ultrastructural aspects and etiopathogenic classification of histiocytosis ] . | NA | {
"id": "C0019621",
"name": "histiocytosis x",
"pos": [
25,
40
]
} | {
"id": "C0019618",
"name": "histiocytosis",
"pos": [
142,
155
]
} |
prostaglandins and their relatives the thromboxanes and prostacyclins are shown to play an important role in the mediation of ocular inflammation . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
0,
14
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
56,
69
]
} |
the syndrome induced by acute cotyledoside poisoning is similar to that of other cardiac glycosides , but the paretic signs of chronic intoxication resemble `` '' krimpsiekte '' '' , a disease associated only with intoxication with the plants of the family crassulaceae . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
4,
12
]
} | {
"id": "C0012634",
"name": "a disea",
"pos": [
183,
190
]
} |
present investigations demonstrated that several amino acids , glycine , alanine , beta-alanine and gaba , and may-be aspartic acid , serine and valine by prolonged irradiation , were formed in the aqueous solutions of ammonium acetate . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
49,
60
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
63,
70
]
} |
present investigations demonstrated that several amino acids , glycine , alanine , beta-alanine and gaba , and may-be aspartic acid , serine and valine by prolonged irradiation , were formed in the aqueous solutions of ammonium acetate . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
49,
60
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
88,
95
]
} |
present investigations demonstrated that several amino acids , glycine , alanine , beta-alanine and gaba , and may-be aspartic acid , serine and valine by prolonged irradiation , were formed in the aqueous solutions of ammonium acetate . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
73,
80
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
83,
95
]
} |
although lens structural proteins are extremely diverse , there appear to be common structural motifs or folding units from which the beta-gamma-crystallins can be constructed . | NA | {
"id": "C0010422",
"name": "lens",
"pos": [
9,
13
]
} | {
"id": "C0005203",
"name": "beta",
"pos": [
134,
138
]
} |
these changes may be induced by 'lens permeability factors ' present and active in the aqueous humor during inflammation , factors that include antigen-antibody complexes , antilens and antiuveoretinal antibodies , phospholipase a and lysophosphatidylcholine ( lpc ) . | NA | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
144,
170
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
202,
212
]
} |
in diabetic patients with poor metabolic control ( group i ) and with repeated hypoglycaemic crises ( group ii ) the serum concentration of cholesterol , triglyceride , of ldl , vldl and hdl-cholesterol , as well of vldl and ldl + hdl-triglyceride were measured before and after metabolic control and before and after co... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
140,
151
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
187,
202
]
} |
parallel with the control of diabetic metabolism in group i , achieved in 15 +/- 6 days , a significant increase in hdl-cholesterol concentration was demonstrable , together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
49,
51
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
246,
253
]
} |
in group ii the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
32,
43
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
44,
49
]
} |
the lectin-binding ability of erythrocyte membranes did not change upon treatment by either endotoxin , whereas that of lymphocytes was stimulated by lps at 10-50 micrograms/ml concentration as well as by rdlps at the lowest dose applied , i.e . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
92,
101
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
207,
210
]
} |
the micromorphological investigations by scanning electron microscopy ( sem ) support our data concerning the functional alterations of plasma membranes of platelets and lymphocytes after lps and rdlps treatment as well as after the combined effect of endotoxin pretreatment and x-irradiation , since a severe smoothenin... | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
188,
191
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
252,
261
]
} |
we determined twelve antigens of the hla-a locus and thirteen antigens of the hla-b locus . | NA | {
"id": "C0019721",
"name": "antigens",
"pos": [
21,
29
]
} | {
"id": "C0019737",
"name": "antigens",
"pos": [
62,
70
]
} |
new cephalosporins ( cefamandole , cefoxitin , cefotaxime , moxalactam , and cefoperazone ) are often substituted in situations where older , `` '' first-generation '' '' cephalosporins or other antimicrobials traditionally have been used . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
21,
32
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
77,
89
]
} |
the antimicrobial spectra , pharmacokinetics , tissue penetration , side effects , clinical trials and indications , dosage , and cost of mezlocillin ( mezlin ) and piperacillin ( pipracil ) , two new semisynthetic beta-lactam penicillins , are reviewed . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
215,
226
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
227,
238
]
} |
however , the half-life of mezlocillin in renal failure is longer then the half-life of piperacillin because of dose-dependent kinetics of mezlocillin at low glomecular filtration rates . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
14,
23
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
127,
135
]
} |
it is approved by fda for treating candidiasis , chronic mucocutaneous candidiasis , oral thrush , candiduria , coccidioidomycosis , histoplasmosis , chromomycosis , and paracoccidioidomycosis . | NA | {
"id": "C0006840",
"name": "candidiasis",
"pos": [
35,
46
]
} | {
"id": "C0006845",
"name": "chronic",
"pos": [
49,
56
]
} |
naproxen and naproxen sodium have both been shown to be superior to placebo in subjective and objective assessments of dysmenorrheic patients when administered at the onset of symptoms . | NA | {
"id": "C0027396",
"name": "naproxen",
"pos": [
0,
8
]
} | {
"id": "C0546873",
"name": "naproxen",
"pos": [
13,
21
]
} |
the fenamates appear to be effective in dysmenorrhea , although they were not studied extensively with placebo and previous experience with mefenamic acid has led to warnings about side effects . | NA | {
"id": "C1955898",
"name": "fenamates",
"pos": [
4,
13
]
} | {
"id": "C0025152",
"name": "mefenamic acid",
"pos": [
140,
154
]
} |
hetastarch is a plasma volume expander used in adults for the treatment of shock caused by hemorrhage , burns , surgery , sepsis , or other trauma . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
104,
109
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
140,
146
]
} |
it is a heterogenous macromolecular agent derived from starch and is composed primarily of amylopectin . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
55,
61
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
91,
102
]
} |
one hundred and twenty-one patients receiving 140 courses of aminoglycoside-therapy ( 76 % gentamicin and 24 % tobramycin ) were retrospectively studied to assess the monitoring practices for these drugs . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
61,
75
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
91,
101
]
} |
a comparison of the fate of inhaled methyl chloroform ( 1,1,1-trichloroethane ) following single or repeated exposure in rats and mice . | NA | {
"id": "C0043697",
"name": "methyl chloroform",
"pos": [
36,
53
]
} | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
62,
77
]
} |
it is likely that the dependence of apparent half-life on pre-strike pbb is primarily a reflection of interindividual differences in lead kinetics in these men . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
45,
54
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
138,
146
]
} |
antigens effective in detecting antibodies to hdi or hmi were tested for ability to detect reaginic antibodies in a worker with clinical `` '' hdi '' '' asthma . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
32,
42
]
} | {
"id": "C0034761",
"name": "reaginic",
"pos": [
91,
99
]
} |
it could not be determined with certainty whether the extraovarian tumor represented metastatic spread or synchronous tumor formation . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
67,
72
]
} | {
"id": "C0027663",
"name": "synchronous tumor",
"pos": [
106,
123
]
} |
plasma haloperidol levels were assayed in 181 chronic schizophrenic inpatients , who were monthly injected intramuscularly with haloperidol decanoate . | NA | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
7,
18
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
128,
149
]
} |
the spinothalamic tract which is conceived to be the chief pathway for nociceptive pain and whose interruption induces dissociated sensory loss can be recognized from the anterolateral columns of the spinal cord to the posterior thalamus by the induction of feelings of chiefly contralateral , somatotopographically orga... | NA | {
"id": "C3178766",
"name": "nociceptive pain",
"pos": [
71,
87
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
393,
397
]
} |
thus four brain systems involved in pain signalling can be recognized by electrical stimulation , one which conveys nociceptive pain to consciousness , another that suppresses it , one that may undergo denervation neuronal hypersensitivity and bring deafferentation pain into consciousness , possibly by establishing nov... | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
36,
40
]
} | {
"id": "C3178766",
"name": "nociceptive pain",
"pos": [
116,
132
]
} |
in addition to ethanol , inhibition of forskolin activation was observed with acetone , n-butanol , t-butanol , dimethyl formamide , dioxane , methanol and n-propanol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
15,
22
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
143,
151
]
} |
dietary fat ( total fat , saturated fat , unsaturated fat , and cholesterol ) did not correlate with hdl-c . | NA | {
"id": "C0012171",
"name": "dietary fat",
"pos": [
0,
11
]
} | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
42,
57
]
} |
dietary fat ( total fat , saturated fat , unsaturated fat , and cholesterol ) did not correlate with hdl-c . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
64,
75
]
} | {
"id": "C0023822",
"name": "hdl-c",
"pos": [
101,
106
]
} |
studies on the binding spectra of certain alkaloids with rat liver microsomes revealed that brucine , scopolamine and strychnine are type i compounds , whereas boldine , emetine , nicotine , reserpine and sanguinarine show type ii binding . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
42,
51
]
} | {
"id": "C0013974",
"name": "emetine",
"pos": [
170,
177
]
} |
in vitro incubation of colchicine , nicotine or scopolamine with microsomal suspensions and nadph resulted in demethylation of these alkaloids , while the incubation of boldine , brucine , emetine , reserpine , sanguinarine or solanine showed little or no dealkylation reaction . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
23,
33
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
133,
142
]
} |
in vitro incubation of colchicine , nicotine or scopolamine with microsomal suspensions and nadph resulted in demethylation of these alkaloids , while the incubation of boldine , brucine , emetine , reserpine , sanguinarine or solanine showed little or no dealkylation reaction . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
133,
142
]
} | {
"id": "C0013974",
"name": "emetine",
"pos": [
189,
196
]
} |
gammaglobulin , immunoglobulin , transferrin , and some complement fractions ( particularly c ' 3 , c ' 1 ina , c ' 3 pa ) were lower in infants receiving soy protein diets than in those receiving cow milk protein diets , and , within each type of diet , in those infants receiving lower amounts of protein . | NA | {
"id": "C0017007",
"name": "gammaglobulin",
"pos": [
0,
13
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
16,
30
]
} |
on seven occasions the app levels did not match the clinically assessed disease activity , but when the serum levels were related to outcome of the disease , c-reactive protein was found to be elevated -- whether or not there were symptoms of the disease -- in all patients who later had a relapse , while normal values ... | NA | {
"id": "C0001347",
"name": "app",
"pos": [
23,
26
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
158,
176
]
} |
cii may be useful in extremely premature , very-low-birth-weight infants in whom glucose intolerance persists despite conservative treatment , and either severely limits caloric intake , or results in life-threatening hyperglycemia . | NA | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
81,
100
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
218,
231
]
} |
the effect of human growth hormone ( hgh ) on gastrin secretion was evaluated in 13 hyposomatotropic children and two subjects with bioinactive growth hormone ( gh ) . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
14,
34
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
144,
158
]
} |
of the dnas derived from mycobacteria , those of m. tuberculosis and m. scrofulaceum showed a comparatively high reassociation with the dna of m. leprae . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
7,
11
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
150,
151
]
} |
the nitric oxide complex of the manganese ( ii ) -protein shows a hyper-metalloporphyrin spectrum suggestive of thiolate ligation to the porphyrin-bound manganese ion . | NA | {
"id": "C0025541",
"name": "metalloporphyrin",
"pos": [
72,
88
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
137,
146
]
} |
if one assays shortly after its introduction into mammalian cells , it can be shown that this recombinant plasmid programs the synthesis of correctly spliced and polyadenylylated insulin mrna that functions in the synthesis and secretion of rat proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
179,
186
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
245,
255
]
} |
the initiation codon is followed by a cysteine codon that is not found at the amino-terminal site of any actin isoform , suggesting the necessity of post-translational processing for in vivo actin synthesis . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
4,
20
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
47,
52
]
} |
32p-labeled human or mouse dnas hybridize to the ir3 sequence on southern blots of viral dna . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
27,
31
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
83,
92
]
} |
the amount of total rna , poly ( a ) + rna , histone mrna , actin mrna , alpha-tubulin mrna , and mitochondrial rrna was determined for each fragment . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
112,
116
]
} |
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