text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the structure of the basement membrane of the high endothelium of reactive human lymph nodes was investigated by techniques selective for carbohydrates ( periodic acid-schiff ; critical electrolyte concentration staining with alcian blue ; lectin histochemistry ) , specific proteins ( immunohistochemistry for laminin a... | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
240,
246
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
275,
283
]
} |
in the present study phenotypic properties of non-stimulated and stimulated blood monocytes and of their normal macrophage derivatives were studied applying enzyme cytochemistry , isoenzyme analysis of acid esterase ( ec 3.1.1.6 ) , and immunohistochemical staining using a panel of newly established monoclonal antibodi... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
157,
163
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
180,
189
]
} |
in the hepatopancreas the absolute and relative quantities of phosphorus , sulphur and other elements change in phase with the moult cycle . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
62,
72
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
93,
101
]
} |
although the possibility of the involvement of hydroxyl radicals in asa cytotoxicity can not be ruled out , it appears that the toxic effect of asa is due mostly to the formation of products of oxidation of asa and particularly to dehydroascorbic acid ( dha ) . | NA | {
"id": "C0003968",
"name": "asa",
"pos": [
68,
71
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
231,
251
]
} |
these data show that radiation-induced increases in itxb2 excretion are primarily due to altered extrarenal synthesis and/or metabolism of this arachidonate metabolite . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
58,
67
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
125,
135
]
} |
however , we observed that endotoxin increased lung dry weight ( per unit body weight ) , which may have attenuated the change in wet-to-dry weight ratios . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
74,
85
]
} | {
"id": "C0005911",
"name": "change in",
"pos": [
120,
129
]
} |
endogenous glucose may be incorporated in glycogen in working muscle and may be used directly for liver glycogen synthesis rather than after conversion to trioses . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
42,
50
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
98,
112
]
} |
lung putrescine and spermidine specific contents also peaked during this period , but spermine specific content remained relatively unchanged . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
5,
15
]
} | {
"id": "C0037871",
"name": "specific",
"pos": [
95,
103
]
} |
lung putrescine and spermidine specific contents also peaked during this period , but spermine specific content remained relatively unchanged . | NA | {
"id": "C0037871",
"name": "specific",
"pos": [
31,
39
]
} | {
"id": "C0037874",
"name": "specific",
"pos": [
95,
103
]
} |
the specific irreversible odc inhibitor , alpha-difluoromethylornithine , significantly reduced lung-odc activity and putrescine and spermidine specific content ; | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
118,
128
]
} | {
"id": "C0037871",
"name": "specific",
"pos": [
144,
152
]
} |
these findings suggest that kyn-1 is a new human hcc cell line with transformation to adenocarcinoma , which will provide useful information to clarify the histogenesis of combined hepatocellular and cholangiocellular carcinoma . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
86,
100
]
} | {
"id": "C0206698",
"name": "cholangiocellular",
"pos": [
200,
217
]
} |
trichosporon cutaneum is shown to utilize six disaccharides , cellobiose , maltose , lactose , sucrose , melibiose , and trehalose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
46,
59
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
75,
82
]
} |
trichosporon cutaneum is shown to utilize six disaccharides , cellobiose , maltose , lactose , sucrose , melibiose , and trehalose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
46,
59
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
95,
102
]
} |
trichosporon cutaneum is shown to utilize six disaccharides , cellobiose , maltose , lactose , sucrose , melibiose , and trehalose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
46,
59
]
} | {
"id": "C0025228",
"name": "melibiose",
"pos": [
105,
114
]
} |
since pfa10 dna linearized by a restriction enzyme was not further cut during uptake , the endonucleolytic activity associated with entry of plasmid dna appeared to act preferentially on circular dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
12,
15
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
187,
199
]
} |
peptides composed of l-amino acids competed more effectively than did peptides containing d-residues or glycine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
23,
28
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
104,
111
]
} |
although glycosyl diacylglycerols are common membrane components of gram-positive bacteria , this report represents the first substantial evidence for the presence of a glycosyl diacylglycerol within a member of the mycobacterium genus . | NA | {
"id": "C0012262",
"name": "diacylglycerols",
"pos": [
18,
33
]
} | {
"id": "C0043791",
"name": "diacylglycerol",
"pos": [
178,
192
]
} |
the enzyme contained five subunits ( mrs 89,000 , 71,000 , 60,000 , 58,000 , and 19,000 ) , suggesting a multifunctional enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
121,
127
]
} |
the pattern of potassium cyanide inhibition indicated that cyanide binds at or near the co binding site . | NA | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
15,
32
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
59,
66
]
} |
expression of the cloned anabaena thioredoxin gene in e. coli was substantiated by subsequent purification and characterization of the algal protein from e. coli . | NA | {
"id": "C0039938",
"name": "thioredoxin",
"pos": [
34,
45
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
141,
148
]
} |
alfalfa tumor dna may contain one more hindiii fragment at the left end of tl-dna than does soybean tumor dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
14,
17
]
} | {
"id": "C0012930",
"name": "tumor dna",
"pos": [
100,
109
]
} |
fumarate reductase ( encoded by frd ) and succinate dehydrogenase ( encoded by sdh ) of escherichia coli are both known to catalyze the interconversion of fumarate and succinate . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
42,
65
]
} | {
"id": "C0283592",
"name": "sdh",
"pos": [
79,
82
]
} |
phytohemagglutinin ( pha ) and a tumor-promoting phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) act synergistically to induce interleukin 2 ( il2 ) mrna in human lymphocytes in vitro . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
49,
62
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
65,
101
]
} |
the isoelectric points of albumin tokushima were ph 4.70 and 4.90 as compared with ph 5.05 and 5.25 of a normal serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
26,
33
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
112,
125
]
} |
boiling and treatment of the enzyme at ph 10.5 suggested that enzyme aggregates contained dextran or its fragments bound to the enzyme and the enzyme-dextran complex showed the charge isomerism . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
29,
35
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
143,
149
]
} |
comparative studies on this enzyme and its isozyme purified from chicken liver mitochondria were performed . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
28,
34
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
43,
50
]
} |
we cloned human lymphotoxin ( lt ) cdna from a cdna library prepared from phorbol myristate acetate ( pma ) and con a-stimulated human t cell hybridoma ( ac5-8 ) cells , the nucleotide sequence of the cdna insert in the plasmid , plt13 , was determined and compared with those of peripheral blood mononuclear cell derive... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
162,
167
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cell",
"pos": [
280,
313
]
} |
the transition between fully reduced ( active ) and fully oxidized ( inactive ) enzyme is half complete at a [ gsh ] / [ gssg ] ratio of 6.5 +/- 1 at ph 8.0 and 5.6 +/- 0.9 at ph 7.2 . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
111,
114
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
121,
125
]
} |
equilibration of the enzyme with a redox buffer of gsh and gssg shows a monophasic equilibration of the activity . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
51,
54
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
59,
63
]
} |
the ratio of gsh/gssg where the enzyme is 50 % active ( r0.5 ) is 0.06 +/- 0.03 . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
13,
16
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
17,
21
]
} |
the ratios of the observed second-order rate constants for gssg inactivation and gsh reactivation do not lead to a correct value of the observed thiol/disulfide oxidation equilibrium constant . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
59,
63
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
81,
84
]
} |
furthermore , when the cells were pretreated with egf , the microsomes exhibited an increased activity of fatty acid cyclooxygenase ( arachidonic acid -- -- pgh2 ) , whereas the activity of pge synthase ( pgh2 -- -- pge2 ) remained unchanged . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
190,
193
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
216,
220
]
} |
the membrane-associated folate-binding protein contains 45,000 g of amino acids and the soluble folate-binding protein contains 24,000 g of amino acids per mole of folate bound . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
4,
12
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
111,
118
]
} |
these observations suggest that : protein kinase c activation by free fatty acid is specific to the cis-form and is not due to their detergent-like action , cis-fatty acid activation is due to the direct interaction of protein kinase c with the monomeric form of cis-fatty acids and not with the micelles of fatty acids ... | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
65,
80
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
330,
341
]
} |
it is likely that either singlet oxygen or superoxide and hydroxyl radicals are involved in the attack on heme iron , because inactivation correlates with oxygen production and can be decreased to a certain degree by scavengers such as ethanol , 1-propanol , 2-propanol , or mannitol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
236,
243
]
} | {
"id": "C0022237",
"name": "2-propanol",
"pos": [
259,
269
]
} |
eif-4a does , however , enhance rna-dependent atp hydrolysis in the presence of either eif-4b or eif-4f . | NA | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
0,
6
]
} | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
97,
103
]
} |
specific binding at 4 degrees c was demonstrated for apoe-free hdl , apoa-iv x popc , and apoe x popc but not for apoa-i x popc . | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
53,
57
]
} | {
"id": "C0052198",
"name": "apoe",
"pos": [
90,
94
]
} |
binding of apoa-iv x popc was inhibited by apoe-free hdl , apoa-iv x popc , and apoa-iv + apoa-i x popc , but not by apoe x popc or apoe-enriched hdl . | NA | {
"id": "C0052198",
"name": "apoe",
"pos": [
43,
47
]
} | {
"id": "C0003595",
"name": "apoe",
"pos": [
132,
136
]
} |
the activity was solubilized from trypanosome membrane fractions in non-ionic detergent and purified by anion exchange chromatography on deae-cellulose followed by chromatography on phosphatidylinositol-sepharose . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
72,
77
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
104,
109
]
} |
we have proposed , using styrene as a model , a new mechanism for the formation of glutathione conjugates that is independent of epoxide formation but dependent on the oxidation of glutathione to a thiyl radical by peroxidases such as prostaglandin h synthase or horseradish peroxidase . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
215,
226
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
263,
285
]
} |
rat liver multivesicular bodies ( mvb ) , as well as other hepatic subcellular organelles , are acidified by an electrogenic atp-dependent proton pump that requires cl- for maximal acidification ( van dyke , r. w. , hornick , c. a. , belcher , j. , scharschmidt , b. f. , and havel , r.j. ( 1985 ) j. biol . chem . 260 ,... | NA | {
"id": "C0016327",
"name": "f",
"pos": [
101,
102
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
399,
404
]
} |
the data are consistent with a mechanism which proposes that , after mg2+ binding , cytochalasin d binds and induces a second conformational change which results in overall tight binding of the cytochalasin . | NA | {
"id": "C0010738",
"name": "cytochalasin d",
"pos": [
84,
98
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
194,
206
]
} |
a mechanism for the effect of cytochalasin d on actin polymerization is presented , which explains the experimental observation of a cytochalasin d-induced increase in the initial rate of polymerization and a decrease in the final extent of the reaction . | NA | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
30,
42
]
} | {
"id": "C0010738",
"name": "cytochalasin d",
"pos": [
133,
147
]
} |
sodium-dependent beta-alanine transport was markedly anion-dependent , being highest in the presence of chloride ( cl greater than br greater than scn greater than no3 approximately i greater than f ) and virtually nonexistent in the presence of gluconate and other nonphysiological chloride substitutes . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
53,
58
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
297,
298
]
} |
sodium-dependent beta-alanine transport was markedly anion-dependent , being highest in the presence of chloride ( cl greater than br greater than scn greater than no3 approximately i greater than f ) and virtually nonexistent in the presence of gluconate and other nonphysiological chloride substitutes . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
53,
58
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
244,
245
]
} |
sodium-dependent beta-alanine transport was markedly anion-dependent , being highest in the presence of chloride ( cl greater than br greater than scn greater than no3 approximately i greater than f ) and virtually nonexistent in the presence of gluconate and other nonphysiological chloride substitutes . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
53,
58
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
283,
291
]
} |
when digested with proteases and glycosidases , higher molecular weight forms of tyrosinase co-migrated with the purified enzyme in isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggesting that the isozyme was derived from larger precursors . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
122,
128
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
235,
242
]
} |
these data , correlating changes in the environment of the noncatalytic or regulatory nucleotide binding site on the ca2+-atpase with coupling activity , indicate that uncoupling is an intramolecular process , involving a ligand binding site on the atpase , and that exclusion of h2o from the site occupied by noncatalyt... | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
117,
120
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
249,
255
]
} |
in the present study it is demonstrated that platelet-activating factor ( paf ) was produced by chick retinas , upon stimulation with neurotransmitters such as acetylcholine ( ach ) , dopamine , or with calcium ionophore a23187 , but not upon stimulation with gamma-amino-n-butyric acid , l-glycine , l-glutamate , epine... | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
266,
271
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
291,
298
]
} |
bovine pancreatic trypsin and chymotrypsin in the external medium mimicked the signalling events which were triggered by the serine protease on the t cell surfaces . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
18,
25
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
125,
140
]
} |
bovine pancreatic trypsin and chymotrypsin in the external medium mimicked the signalling events which were triggered by the serine protease on the t cell surfaces . | NA | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
30,
42
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
125,
140
]
} |
from the reaction time ( within 1 s ) and its specificity , this serine protease in cytotoxic t cells was considered to be different from a protease which works at the killing stage . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
65,
80
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
140,
148
]
} |
reactivity with antibodies eluted from diseased kidneys of sheep immunized with hgbm ( steblay nephritis ) was compared with goodpasture autoantibody reactivity by immunoblotting two-dimensional gels of hgbm nc1 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
16,
26
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
137,
149
]
} |
guanosine 5'-o- ( 3-thiotriphosphate ) ( gtp gamma s ) was the most potent guanine nucleotide with a half-maximal stimulation at 1-10 microm , followed by guanosine 5'- ( beta , gamma-imido ) triphosphate greater than gtp greater than gdp = guanosine 5'-o- ( 2-thiodiphosphate ) . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
41,
52
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
218,
221
]
} |
when the production of phosphocreatine is coupled to electron transport via mitochondrial creatine kinase , the net reaction can be expressed by the balanced equation : creatine + pi -- -- phosphocreatine + h2o . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
30,
38
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
189,
204
]
} |
this suggests that rates of oxygen consumption could be regulated by changes in [ creatine ] , [ pi ] , or [ phosphocreatine ] , alone or in combination . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
82,
90
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
109,
124
]
} |
under physiological conditions , with 5.0 mm creatine , increases in pi or decreases in phosphocreatine had little influence upon mitochondrial respiration . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
45,
53
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
88,
103
]
} |
when phosphocreatine was held constant ( 15 mm ) , changes in [ creatine ] modestly stimulated respiratory rates , whereas pi again showed little effect . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
5,
20
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
64,
72
]
} |
overall , the data show how increasing [ creatine ] and decreasing [ phosphocreatine ] influence the rates of oxidative phosphorylation when mediated by mitochondrial creatine kinase . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
41,
49
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
69,
84
]
} |
incorporation of [ 35s ] sulfate into macromolecules was linear over 16 h in vitro , and ds was the predominant glycosaminoglycan ( gag ) , while hs dominated in vivo incubations . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
112,
129
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
146,
148
]
} |
the first , hs-tia , had an mr of 130 x 10 ( 3 ) with mr 12.5 x 10 ( 3 ) gag chains . | NA | {
"id": "C0019143",
"name": "hs",
"pos": [
12,
14
]
} | {
"id": "C0017973",
"name": "gag",
"pos": [
73,
76
]
} |
thus , glomeruli rapidly synthesized and released sepharose cl-6b-included heparin-displaceable ds and hs proteoglycans while retaining a sepharose cl-6b-excluded self-associating ds proteoglycan and an intracellular hs . | NA | {
"id": "C0062503",
"name": "hs",
"pos": [
103,
105
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
217,
219
]
} |
the high and the low mr forms of free sc ( or iga-dissociated bound sc ) and the native secretory iga complex were subjected to limited tryptic digestion . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
38,
40
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
88,
101
]
} |
in hyperpolarized unilamellar liposomes , pardaxin i produced a fast , nonspecific permeabilization and in multilamellar liposomes , a slow , cation-specific pore . | NA | {
"id": "C1721091",
"name": "unilamellar",
"pos": [
18,
29
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
121,
130
]
} |
biologically active , recombinant dna in clathrin-coated vesicles isolated from rat livers after in vivo injection of liposome-encapsulated dna . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
22,
37
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
140,
143
]
} |
when exposed to agarose-coupled lectins , the detergent solubilized , labeled mr = 92,000 protein was completely adsorbed to wheat germ agglutinin , partially to ricin communis ii , and not at all to concanavalin a or lotus or lentil lectin . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
32,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
90,
97
]
} |
when heterozygous npc fibroblasts were incubated with ldl or fbs , cellular accumulation of cholesterol reached levels that were high-normal or intermediary between levels observed in normal and homozygous npc fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
67,
75
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
210,
221
]
} |
growth hormone-releasing factor ( grf ) stimulates the release of growth hormone from the anterior pituitary and is related to the peptides of the glucagon/secretin family . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
0,
14
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
90,
108
]
} |
we have isolated cdna clones for the rat stomach ( h+ + k+ ) -atpase by employing a novel procedure involving the use of oligonucleotides corresponding to conserved amino acid sequences of related cation transport atpase and a cross-hybridization with the sheep kidney ( na+ + k+ ) -atpase alpha-subunit cdna . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
62,
68
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
306,
308
]
} |
amino acid homology and hydropathy plot comparisons between the gastric atpase and the ( na+ + k+ ) -atpase catalytic subunit demonstrate a striking similarity which suggests that their higher order structure and mechanism of action are virtually identical . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
72,
78
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
89,
91
]
} |
the cytochrome p-450-mediated reactions of the synthetic stilbene estrogen ( e ) -diethylstilbestrol ( des ) and of 2-hydroxyestradiol have been investigated in vitro . | NA | {
"id": "C0038333",
"name": "stilbene",
"pos": [
57,
65
]
} | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
82,
100
]
} |
cycloheximide inhibited the induction of transcription of the albumin gene by dexamethasone , suggesting that a rapidly induced mediator protein , which is also regulated by glucocorticoid , is involved in the induction of albumin gene expression by glucocorticoid . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
137,
144
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
223,
230
]
} |
whereas thrombin is a potent activator of phospholipase c as judged by the rapid release of inositol trisphosphate , inositol bisphosphate and by the massive accumulation of total inositol phosphate ( ip ) in the presence of 20 mm li+ , fgf failed to induce the breakdown of polyphosphoinositides in quiescent ccl39 cell... | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
92,
100
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
180,
198
]
} |
on adding atp to the manganese-enzyme mixture , a tertiary complex of mn2+ x atp x enzyme was formed as indicated by the appearance of a second shell . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
31,
37
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
59,
66
]
} |
the stimulation of atp hydrolysis by anions such as selenite may be the result of shortening the distance between mn2+ and the atp phosphates in the enzyme active site . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
37,
43
]
} | {
"id": "C0031603",
"name": "phosphates",
"pos": [
131,
141
]
} |
specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
37,
49
]
} | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
76,
87
]
} |
in the case of abundant free water ( high ph ) and high freezing temperature , the pore size was greatest because of enhanced ice crystal growth . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
29,
34
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
126,
129
]
} |
histopathologic evaluation following chronic implantation of chromium and steel based metal alloys in the rabbit central nervous system . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
74,
79
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
92,
98
]
} |
two of the alloys tested ( chromium based mp35n , trademark of the standard pressed steel company , and a stainless steel alloy , bg42 vacarc , trademark of latrobe steel ) appeared suitable as cns implants . | NA | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
106,
121
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
165,
170
]
} |
two of the alloys tested ( chromium based mp35n , trademark of the standard pressed steel company , and a stainless steel alloy , bg42 vacarc , trademark of latrobe steel ) appeared suitable as cns implants . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
11,
16
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
165,
170
]
} |
the third alloy ( stainless steel 440c , carpenter steel company ) showed more corrosion than the other alloys , and may be less suitable for implantation . | NA | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
18,
33
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
51,
56
]
} |
the third alloy ( stainless steel 440c , carpenter steel company ) showed more corrosion than the other alloys , and may be less suitable for implantation . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
28,
33
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
104,
110
]
} |
we found that it increased compartment pressure and helped to reduce bleeding , tissue oedema and the size of effusions and haemarthroses . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
69,
77
]
} | {
"id": "C0018924",
"name": "haemarthroses",
"pos": [
124,
137
]
} |
the presence of ndea had little effect on dna methylation by ndma , suggesting that neither synergism nor competition occurs in the simultaneous activation of these two nitrosamines . | NA | {
"id": "C0012200",
"name": "ndea",
"pos": [
16,
20
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
169,
181
]
} |
the presence of ndea had little effect on dna methylation by ndma , suggesting that neither synergism nor competition occurs in the simultaneous activation of these two nitrosamines . | NA | {
"id": "C0012431",
"name": "ndma",
"pos": [
61,
65
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
169,
181
]
} |
induction of arg+ mutations by dena and several other aliphatic nitrosamines is mainly due to base pair substitutions , whereas ndela is rather mutagenic in the galrs system . | NA | {
"id": "C0012200",
"name": "dena",
"pos": [
31,
35
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
64,
76
]
} |
furthermore , we observed that 45-65 % of fibronectin subunits from transformed cells or normal embryonic fibroblasts are sialylated on the heparin-binding domain 5 , whereas this occurs in only 24-28 % of fibronectin subunits from normal adult fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
245,
256
]
} |
in addition , mab 48.7 also recognizes an epitope on a 250,000-d glycoprotein and is therefore similar to antibody 9.2.27 ( described by bumol , t.f. , and r.a . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
14,
17
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
106,
114
]
} |
the rate of biosynthesis of procollagen iv , the principal collagen of basement membranes , and the concentration of specific rnas coding for procollagen iv were measured in neonatal rat lungs . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
31,
39
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
142,
153
]
} |
in this study , we have generated and separated a variety of peptide fragments from n-cam , and then used their size and reactivity with each antibody to position the antigenic sites along the peptide chain . | NA | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
61,
78
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
193,
200
]
} |
rnas derived from the xk81 keratin subfamily are undetectable in the adult , where different type i keratin genes are expressed . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
27,
34
]
} | {
"id": "C1179970",
"name": "type i keratin",
"pos": [
93,
107
]
} |
we have examined and compared a number of cellular and biochemical events associated with the recovery process of rat fibroblasts placed under stress by different agents . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
42,
50
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
118,
129
]
} |
it was found that catecholamines increased amp levels in the potency order isoproterenol greater than norepinephrine greater than epinephrine and the receptor involved was a beta adrenergic receptor . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
18,
32
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
75,
88
]
} |
it was found that catecholamines increased amp levels in the potency order isoproterenol greater than norepinephrine greater than epinephrine and the receptor involved was a beta adrenergic receptor . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
130,
141
]
} |
when the effects of catecholamines were measured on inositol phosphate release , the potency order for catecholamine stimulation was epinephrine greater than norepinephrine greater than isoproterenol , and the receptor involved was an alpha 1 adrenergic receptor . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
20,
33
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
186,
199
]
} |
when the effects of catecholamines were measured on inositol phosphate release , the potency order for catecholamine stimulation was epinephrine greater than norepinephrine greater than isoproterenol , and the receptor involved was an alpha 1 adrenergic receptor . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
133,
144
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} |
when fluorescent antibody staining of both whole cells and isolated nuclei is done , several of these monoclonal antibodies react strongly with nuclei . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
17,
25
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
102,
123
]
} |
quantitation by elisa of an extract from 2-wk cultures demonstrated that the neonatal mhc represented between 10 and 15 % of the total myosin . | NA | {
"id": "C0027100",
"name": "mhc",
"pos": [
86,
89
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
135,
141
]
} |
proinsulin is a single polypeptide chain composed of the b and a subunits of insulin joined by the c-peptide region . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
77,
84
]
} |
proinsulin is a single polypeptide chain composed of the b and a subunits of insulin joined by the c-peptide region . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
99,
108
]
} |
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