text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these results suggest that the hyperpolarizations induced by gaba and baclofen may be generated by k+ conductances of different kinetic and pharmacologic properties . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
61,
65
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
70,
78
]
} |
epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
the interaction of the catecholamines epinephrine ( e ) and norepinephrine ( ne ) ( 1.0-100 microm ) and excitatory amino acids on motoneurons of the isolated superfused frog spinal cord was investigated by sucrose gap recordings from ventral roots . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
38,
49
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
the immunohistochemical localization of peptide f and the related enkephalins met5-enkephalin ( met-enk ) , leu5-enkephalin ( leu-enk ) , met5-enkephalin-arg6-phe7 ( met-enk-arg-phe ) , and met5-enkephalin-arg6-gly7-leu8 ( met-enk-arg-gly-leu ) was investigated by means of the indirect immunofluorescence technique in t... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
66,
76
]
} | {
"id": "C0014294",
"name": "met-enk",
"pos": [
223,
230
]
} |
by comparing the distribution of immunoreactive peptide f with other related enkephalins met-enk , leu-enk , met-enk-arg-phe , and met-enk-arg-gly-leu , we observed that there was a remarkable similarity in the distribution of peptide f and other enkephalins in the gi tract . | NA | {
"id": "C0014294",
"name": "met-enk",
"pos": [
89,
96
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
247,
258
]
} |
the allergen-specific suppressor activity was determined by the extent of house-dust-activated , interleukin-2 ( il-2 ) -expanded lymphocytes to suppress the allergen-induced proliferation of autologous mononuclear cells ( mnc ) ; | NA | {
"id": "C0524581",
"name": "house-dust",
"pos": [
74,
84
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
158,
166
]
} |
[ studies on gingivitis in puberty -- relationship between salivary sex hormones and gingival conditions or subgingival plaque ] . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
13,
23
]
} | {
"id": "C0017563",
"name": "gingival conditions",
"pos": [
85,
104
]
} |
we evaluated the effect of different bed and body positions on the increased respiratory rate observed in infants with transient tachypnea of the newborn ( ttn ) , infant respiratory distress syndrome ( rds ) , and bronchopulmonary dysplasia ( bpd ) . | NA | {
"id": "C0158940",
"name": "ttn",
"pos": [
156,
159
]
} | {
"id": "C0035220",
"name": "infant respiratory",
"pos": [
164,
182
]
} |
seventeen infants were studied ( ttn , n = 6 ; rds , n = 6 ; bpd , n = 5 ) in four different positions : supine flat , supine elevated , prone flat , and prone elevated . | NA | {
"id": "C0158940",
"name": "ttn",
"pos": [
33,
36
]
} | {
"id": "C0035220",
"name": "rds",
"pos": [
47,
50
]
} |
the present paper evaluated the rate of weight gain in 68 patients with anorexia nervosa ( 100 consecutive admissions to a specialised eating disorders unit ) using a lenient , flexible approach to refeeding . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
72,
88
]
} | {
"id": "C0013473",
"name": "eating disorders",
"pos": [
135,
151
]
} |
the finding that most cases of anorexia nervosa gained weight at follow-up was similar to an earlier report ; | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
4,
11
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
55,
61
]
} |
clomipramine and mianserin were significantly superior to placebo in the topographical pain subgroup with headache using area under the improvement curves as criteria ( p less than 0.05 ) . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
87,
91
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
106,
114
]
} |
the effects on bone remodeling of two anions commonly associated with calcium in the food and supplement chain ( carbonate and phosphate ) were evaluated in a pilot study in eight normal premenopausal women . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
38,
44
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
127,
136
]
} |
several controlled clinical trials documented that mupirocin was significantly better than the polyethylene glycol vehicle alone or ampicillin and as effective as cloxacillin , dicloxacillin , or erythromycin in producing clinical and bacteriological cures in patients with impetigo and wound infections caused by gram-p... | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
163,
174
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
177,
190
]
} |
class iii loci code for components c2 , c4 and factor b ( bf ) of the complement system . | NA | {
"id": "C0033453",
"name": "factor",
"pos": [
47,
53
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
70,
80
]
} |
release is by a diffusion/exchange mechanism in which anions from oral fluids diffuse to the charge sites and exchange with fluoride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
54,
60
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
124,
132
]
} |
although some glucocorticoid-responsive proteins are known ( enzymes of phospholipid synthesis and the antioxidant system ; surfactant associated protein ) , the identity of function of most target proteins awaits further research . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
40,
48
]
} | {
"id": "C0072600",
"name": "surfactant associated protein",
"pos": [
124,
153
]
} |
there are interactions of maternal birthweight with maternal adult weight , pregnancy weight gain , and parity ; | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
35,
46
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
86,
92
]
} |
the predicted effect of maternal birthweight on infant birthweight is enhanced when the mother weighs more , gains more weight during pregnancy , or is multiparous . | NA | {
"id": "C0005612",
"name": "infant",
"pos": [
48,
54
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
120,
126
]
} |
the determinations of sucrose , total monosaccharides , disaccharides , and higher sugars by this procedure were satisfactory and were adopted by the aoac . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
22,
29
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
56,
69
]
} |
the determinations of sucrose , total monosaccharides , disaccharides , and higher sugars by this procedure were satisfactory and were adopted by the aoac . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
22,
29
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
83,
89
]
} |
a method is given for determining monosodium glutamate ( msg ) in soups and soup bases by gas-liquid chromatography ( glc ) of the trimethylsilyl ether derivative of glutamic acid . | NA | {
"id": "C0037511",
"name": "monosodium glutamate",
"pos": [
34,
54
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
166,
179
]
} |
amino acid composition was qualitatively similar in both strains , but mir m7 cocci contained a higher amount of alanine and glucosamine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
113,
120
]
} |
the absence of isolatable s. typhimurium 23s rrna possibly reflected in vivo processing of the rrna before isolation . | NA | {
"id": "C0035704",
"name": "23s rrna",
"pos": [
41,
49
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
95,
99
]
} |
under certain conditions , s. typhimurium rrna formed discrete aggregates which sedimented similarly to intact escherichia coli 23s rrna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
42,
46
]
} | {
"id": "C0035704",
"name": "23s rrna",
"pos": [
128,
136
]
} |
the sole detectable biochemical alteration in nbsa strain is greater than 90 % reduction in the phosphate content of the lipid a region of the lipopolysaccharide . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
121,
128
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
143,
161
]
} |
the enzymic activity was not significantly affected by anions , except for nitrate and iodide , which were inhibitory . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
55,
61
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
75,
82
]
} |
the enzymic activity was not significantly affected by anions , except for nitrate and iodide , which were inhibitory . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
55,
61
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
87,
93
]
} |
phenylthiazolones ( ptas ) of arginine and its homologs and analogs , homoarginine , norarginine ( alpha-amino-gamma-guanidinobutyric acid ) , canavanine , and gamma-hydroxyarginine , were prepared . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
30,
38
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
70,
82
]
} |
pta derivatives of canavanine and homoarginine were hydrolyzed with kcat/km walues of the same order of magnitude as that for pta-arginine . | NA | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
34,
46
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
130,
138
]
} |
among these fatty acids , both myristic and lauric acids appeared to be the most efficient substrates . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
12,
23
]
} | {
"id": "C0023140",
"name": "lauric",
"pos": [
44,
50
]
} |
the inhibition of growth and cell wall synthesis by 3-amino-3-deoxy-d-glucose ( 3-ag ) , which is known to be one of the constituents of the kanamycin molecule and a metabolite of bacillus sp. , was almost completely overcome by glucosamine and n-acetylglucosamine in staphylococcus aureus but scarcely affected by d-glu... | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
229,
240
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
245,
264
]
} |
the antibiotic did not inhibit the incorporation of [ 14c ] glucosamine and [ 3h ] n-acetylglucosamine into the acid-insoluble fraction , but rather enhanced the incorporation of [ 14c ] glucosamine . | NA | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
83,
102
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
187,
198
]
} |
putrescine oxidase [ ec 1.4.3.4 ] of micrococcus rubens oxidizes many kinds of synthetic polyamines : triamines ( spermidine types ) , tetramines ( spermine types ) , and n-substituted putrescines . | NA | {
"id": "C0037871",
"name": "types",
"pos": [
125,
130
]
} | {
"id": "C0037874",
"name": "types",
"pos": [
157,
162
]
} |
hydrogen-tritium exchange titration of the histidine residues in ribonuclease t1 and analysis of their microenvironments . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
0,
8
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
9,
16
]
} |
while most of the phospholipids in the membranes were found by a spin label technique to be uniformly oriented with their long hydrocarbon chains perpendicular to the surfaces of the cellulose sheets , a small fraction of phospholipids were isotropically oriented in multilayer membranes . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
18,
31
]
} | {
"id": "C0771648",
"name": "fraction",
"pos": [
210,
218
]
} |
digestion of myosin in the filamentous state with the protease resulted in the disappearance of myosin heavy chain and light chain 2 , producing two fragments having molecular weights of 130,000 and 94,000 which originated from the degradation of heavy chain . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
13,
19
]
} | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
96,
114
]
} |
the paramagnetic hexacyanochromate ion is useful for mapping the active sites of enzymes for anionic substrates . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
35,
38
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
93,
100
]
} |
a new polyamine has been extracted from an extreme thermophile , thermus thermophilus , and its chemical structure was determined as 1,12-diamino-4,8-diazadodecane , nh2 ( ch2 ) 3nh ( ch2 ) 3nh ( ch2 ) 4nh2 , based on its proton nmr , 13c nmr , and mass spectra . | NA | {
"id": "C0032433",
"name": "polyamine",
"pos": [
6,
15
]
} | {
"id": "C0002508",
"name": "nh2",
"pos": [
203,
206
]
} |
the results are discussed in the context of cholesterol sources for contact-inhibited endothelial cells which do not interiorize low density lipoprotein cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023824",
"name": "low density lipoprotein cholesterol",
"pos": [
129,
164
]
} |
when this effect of gtp is abolished by either cholera toxin or gpp ( nh ) p pretreatment , the inhibitory action of adenosine analogs is also lost . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
20,
23
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
64,
76
]
} |
steady state kinetic tests for enzymic memory have now been done with ascorbate oxidase ( ec 1.10.3.3 ) and aspartate aminotransferase ( ec 2.6.1.1 ) . | NA | {
"id": "C0003967",
"name": "ascorbate oxidase",
"pos": [
70,
87
]
} | {
"id": "C0030016",
"name": "ec",
"pos": [
137,
139
]
} |
the glycoprotein accounting for most of the nonadrenocorticotropic hormone ( acth ) , non-beta-lipotropin ( beta lph ) region of mouse tumor cell pro-acth/endorphin was purified from tumor cell culture medium and shown to contain 1/2 cystine residues . | NA | {
"id": "C0023832",
"name": "lipotropin",
"pos": [
95,
105
]
} | {
"id": "C0033195",
"name": "pro-acth/endorphin",
"pos": [
146,
164
]
} |
the ca2+ loading rate and efficiency are greatest in the membranes of highest protein content ( 0.38 mumol of phospholipid/mg of protein ) , decline slowly as the lipid content is quadrupled , and decrease markedly as the lipid content is quadrupled again . | NA | {
"id": "C0025252",
"name": "membranes",
"pos": [
57,
66
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
129,
136
]
} |
since 90 % or more of the protein of the reconstituted membrane is the calcium pump protein , the number of particles observed by freeze-fracture is directly proportional to the amount of calcium pump protein in the membrane . | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
201,
208
]
} |
it was not possible to incorporate labeled amino acid into albumin or the albumin-like r proteins with pituitary incubates , indicating that albumin-like proteins were not synthesized de novo by pituitary glands . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
59,
66
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
154,
162
]
} |
use of ehdp ( disodium ethane 1-hydroxy , 1-diphosphonate , or disodium etidronate ) is not as yet of proved value in most patients . | NA | {
"id": "C0086268",
"name": "ehdp",
"pos": [
7,
11
]
} | {
"id": "C0037507",
"name": "disodium",
"pos": [
63,
71
]
} |
supracondylar fractures of the elbow resulting in volkmann 's contracture frequently had both an arterial injury and a compartment syndrome . | NA | {
"id": "C0042951",
"name": "volkmann 's",
"pos": [
50,
61
]
} | {
"id": "C0009492",
"name": "compartment syndrome",
"pos": [
119,
139
]
} |
for the past twenty-one years the frequency of volkmann 's contracture has not declined in spite of many published reports on the compartment syndrome , and the hazards of supracondylar fractures and of bryant 's traction . | NA | {
"id": "C0042951",
"name": "volkmann 's contracture",
"pos": [
47,
70
]
} | {
"id": "C0009492",
"name": "compartment syndrome",
"pos": [
130,
150
]
} |
the survey identified 19 per cent of relatives with spondylolysis , and index patients with each type of spondylolisthesis had relatives with the opposite type . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
52,
65
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
105,
122
]
} |
however , there was no single instance of a neural tube defect ( anencephaly , spina bifida with or without meningocele , other generalised vertebral anomalies or spinal dysraphism ) amongst 826 first- , second- or third-degree relatives . | NA | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
65,
76
]
} | {
"id": "C0027794",
"name": "spinal dysraphism",
"pos": [
163,
180
]
} |
however , there was no single instance of a neural tube defect ( anencephaly , spina bifida with or without meningocele , other generalised vertebral anomalies or spinal dysraphism ) amongst 826 first- , second- or third-degree relatives . | NA | {
"id": "C0080178",
"name": "spina bifida",
"pos": [
79,
91
]
} | {
"id": "C0027794",
"name": "spinal dysraphism",
"pos": [
163,
180
]
} |
additionally , an independent estimate of the mhc synthesis rate needed to maintain a constant level of constitutive mhc/cell was calculated from total protein content , percentage mhc , fibroblast doubling time , and mhc half-life . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
121,
125
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
187,
197
]
} |
absorption with embryonic or adult chick heart , brain , retina , liver , erythrocytes , or skeletal muscle fibroblasts failed to remove all reactivity of anti-m-24 for myogenic cells at all stages of development . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
108,
119
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
178,
183
]
} |
these antigens are not loosely adsorbed culture medium components or an artifact of tissue culture because : ( a ) absorption of anti-m-24 with homogenized embryonic muscle removed all antibodies to cultured myoblasts ; | NA | {
"id": "C0020960",
"name": "anti-m-24",
"pos": [
129,
138
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
185,
195
]
} |
absorption of the primary antisera with a variety of peptide fragments of acth and beta-lph demonstrated , immunocytochemically as well as by radioimmunoassay , that the acth and beta-lph antisera were directed to the cooh- and nh ( 2 ) -termini of the peptides , respectively . | NA | {
"id": "C0030935",
"name": "peptide",
"pos": [
53,
60
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
253,
261
]
} |
the matrix consisted of hyaluronic acid and heparan sulfate as the major glycosaminoglycan components and fibronectin and procollagen as major polypeptides as shown by metabolic labeling , gel electrophoresis , immunofluorescence , and collagenase digestion . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
44,
59
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
73,
90
]
} |
the possibility that the lattice structure is an artifact of specimen preparation has been tested by ( a ) subjecting whole cultured cells ( wi-38 , nrk , chick embryo fibroblasts ) to various chemical ( aldehydes , osmium tetroxide ) and nonchemical ( freezing ) fixation schedules , ( b ) examination of model systems ... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
168,
179
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
515,
520
]
} |
the distribution of surface proteins during phagocytosis by rabbit peritoneal polymorphonuclear leukocytes was studied to determine whether the proteins of the phagocytic vesicles of these differentiated cells were representative of the entire set of plasma membrane proteins . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
20,
36
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
267,
275
]
} |
( 1 ) -isoproterenol increased intracellular cyclic amp and acted on hormone secretion in a manner indistinguishable from dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
45,
55
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
122,
142
]
} |
several cationic anaesthetics and barbiturates including bupivacaine , lignocaine and pentobarbital reversibly inhibit myoblast fusion in rat primary muscle cultures . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
34,
46
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
86,
99
]
} |
immediately after capping no homologous or heterologous variable antigen , or host plasma or blood cell antigens , can be detected by immunofluorescence on the cell surface outside the cap ; | NA | {
"id": "C0003333",
"name": "heterologous",
"pos": [
43,
55
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
104,
112
]
} |
the dimensions of the exposed face of each variable antigen molecule may not permit the binding of more than one molecule of immunoglobulin , or perhaps the antigen molecules are so closely packed that most of the antigenic determinants are hidden from antibodies . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
52,
59
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
214,
236
]
} |
in general , pulmonary hydatidosis supposes 22 % of the cases treated in a general surgery unity and 4.9 % correspond to infantile hydatidosis ( 98 cases ) . | NA | {
"id": "C0013505",
"name": "pulmonary hydatidosis",
"pos": [
13,
34
]
} | {
"id": "C0013502",
"name": "hydatidosis",
"pos": [
131,
142
]
} |
pvc is a synthetic , plastic , polymer wire insulating material which releases hydrogen chloride ( hcl ) gas when it is thermally degraded . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
21,
28
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
31,
38
]
} |
the procedure involves sample preparation and direct organic solvent extraction using eta-butyl chloride , amide derivatization by molecular rearrangement , and gas chromatography-chemical ionization mass spectrometry-selected ion monitoring , with methane as the carrier and ammonia as reagent gases . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
276,
283
]
} | {
"id": "C0017110",
"name": "gases",
"pos": [
295,
300
]
} |
sympathetic nervous function was assessed by measurement of plasma norepinephrine , alpha-adrenergic receptor sites on platelet membranes , and urinary excretion of epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
181,
195
]
} |
it is concluded that an increase in plasma and urine sir , the presence of a 6000- to 7000-dalton sir fraction in plasma and urine , a reduction in basal and stimulated pancreatic hormone levels , and tolbutamide-induced somatostatin release can be diagnostic for a somatostatinoma . | NA | {
"id": "C0030292",
"name": "pancreatic hormone",
"pos": [
169,
187
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
266,
278
]
} |
the effect of angiotensin ii and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
14,
28
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
33,
42
]
} |
to assess the role of angiotensin ii ( aii ) in regulating 18-hydroxy-11-deoxycorticosterone ( 18-ohdoc ) secretion in man , isolated human adrenal glomerulosa cells were incubated with aii and/or its competitive antagonist , saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
22,
36
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
226,
235
]
} |
aii 2.4 x 10 ( -8 ) m ) elicited an 80 % increase in 18-ohdoc levels as well as similar increases in aldosterone , 18-hydroxycorticosterone , and corticosterone ( p less than 0.01 ) . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
115,
139
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
146,
160
]
} |
saralasin ( 10 ( -8 ) m ) caused a partial but significant inhibition of aii-stimulated 18-ohdoc production , while 10 ( -6 ) m saralasin blocked aii-stimulated steroidogenesis completely . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
146,
149
]
} |
the direct aii effect on 18-ohdoc secretion and the antagonistic effect of saralasin on both exogenous and endogenous aii-stimulated steroidogenesis , documented in these experiments , indicate that the increase in 18-ohdoc levels after sodium restriction reported in man is probably mediated by the renin-angiotensin sy... | NA | {
"id": "C0003018",
"name": "aii",
"pos": [
11,
14
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
118,
121
]
} |
the direct aii effect on 18-ohdoc secretion and the antagonistic effect of saralasin on both exogenous and endogenous aii-stimulated steroidogenesis , documented in these experiments , indicate that the increase in 18-ohdoc levels after sodium restriction reported in man is probably mediated by the renin-angiotensin sy... | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
75,
84
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
118,
121
]
} |
the plasma levels of all four steroids were decreased in patients with secondary adrenal insufficiency compared to normal adults , but the decrease in dha and dhas was considerably greater than that in cortisol and delta4-a , resulting in significant decreases in the plasma ratios of dha to cortisol , dhas to cortisol ... | NA | {
"id": "C0011185",
"name": "delta4",
"pos": [
215,
221
]
} | {
"id": "C0057277",
"name": "dhas",
"pos": [
344,
348
]
} |
incubations with 1 -- 10 mm dibutyryl cyclic amp significantly increased incorporation into mps , suggesting that effects of fsh may be mediated by cyclic amp . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
28,
48
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
148,
158
]
} |
in addition , analysis of the principal components confirms thestrong analogy between alpha 2 hs and albumin and indicates that serum level behavior of the ap-reactants during the course of the disease closely depends on the protein studied . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
101,
108
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
225,
232
]
} |
for studies on the biosynthesis of procollagen , the cells were incubated with [ ( 14 ) c ] proline in a medium supplemented with ascorbic acid and beta-aminopropionitrile , and the synthesis of nondialyzable [ ( 14 ) c ] hydroxyproline , in relation to dna or cell protein , was taken as an index of procollagen formati... | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
92,
99
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
222,
236
]
} |
five of eight scleroderma fibroblast cell lines demonstrated procollagen biosynthesis rates significantly higher than the controls , and the mean rate of procollagen synthesis by scleroderma fibroblasts was about twice that of the control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
191,
202
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
239,
244
]
} |
however , 60 min after injection of 250 mg of human or rat intestinal chylomicrons into the rat , there was a significant increase in hdl apoa-i that resulted from acquisition of a major fraction of the chylomicron apoa-i . | NA | {
"id": "C0003592",
"name": "apoa",
"pos": [
138,
142
]
} | {
"id": "C0085201",
"name": "apoa-i",
"pos": [
215,
221
]
} |
clinical metastasis heralded the decrease of anti-membrane antibodies with a rise in anti-immunoglobulins , especially anti-idiotypic antibodies and immune complexes containing tumor-directed antibody and either antigen or anti-immunoglobulin . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
149,
165
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
192,
200
]
} |
three heme proteins , hemoglobin , methemoglobin and myoglobin , and the oxidant , methylene blue , abolish the coronary arterial relaxation elicited by no . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
22,
32
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
35,
48
]
} |
addition of either exogenous camp or dibutyryl camp ( db-camp ) produced dose-related increases in calcium efflux which occurred more rapidly with db-camp than with camp . | NA | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
37,
46
]
} | {
"id": "C0001455",
"name": "camp",
"pos": [
165,
169
]
} |
two protein fractions of rice , grain , glutelin and globulin , were prepared by dilute alkali and salt extraction , respectively . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
53,
61
]
} |
dietary regimens in gastrointestinal disease can be divided into two categories : first , those of proven value include : ( a ) disaccharide elimination for disaccharidase deficiency and exclusion of monosaccharides for sugar malabsorption ; | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
200,
215
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
220,
225
]
} |
morphometric studies have shown that wga-hrp conjugates were 40 times more sensitive than free hrp , in the tracing of retrograde connections from the rat submandibular gland to the superior cervical ganglion . | NA | {
"id": "C0078473",
"name": "wga-hrp conjugates",
"pos": [
37,
55
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
95,
98
]
} |
the major findings of this investigation include : 1 ) aldehyde fuchsin staining of nonoxidized pancreatic b cells requires a stain prepared with either paraldehyde or acetaldehyde . | NA | {
"id": "C0030438",
"name": "paraldehyde",
"pos": [
153,
164
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
168,
180
]
} |
the slides were then incubated with cyclic and noncyclic nucleotides , and restoration of distinct cyclic amp and cyclic gmp staining pattern was achieved only with appropriate cyclic nucleotides . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
57,
68
]
} | {
"id": "C0028631",
"name": "cyclic",
"pos": [
177,
183
]
} |
wheat germ agglutinin-horseradish peroxidase conjugates used in vivo for studies of retrograde axonal transport were significantly more sensitive than free horseradish peroxidase . | NA | {
"id": "C0078473",
"name": "wheat germ",
"pos": [
0,
10
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
156,
178
]
} |
urinary 17-ohcs , epinephrine and norepinephrine levels were studied for one week before and one week after the onset of acute , severe adenovirus 4 respiratory illness in 12 army recruits during basic combat training . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
18,
29
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} |
following onset of respiratory illness , 17-ohcs , epinephrine and norepinephrine levels all showed about 60 percent increases over the early pre-illness period baseline value . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
67,
81
]
} |
these cells were also cytostatic for mda 157 , a cell line derived from a pleural effusion of human breast cancer , and hel 23 , a strain of human fetal lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
158,
169
]
} |
tame or bame with anti-ig inhibited the generation of cytoplasmic factor ( s ) and the simultaneous addition of tame or bame with dfp protected the generation of cytoplasmic factor ( s ) against the inhibitory effect of dfp , showing the involvement of trypsin-like , arginine-type serine protease in anti-ig-induced gen... | NA | {
"id": "C0040494",
"name": "tame",
"pos": [
0,
4
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
268,
276
]
} |
this clone x63-ag8.653 can be used for efficient fusion with antibody-forming cells to obtain hybrid cell lines producing pure monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
61,
69
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
127,
148
]
} |
we reached the conclusion that the active material in this model is a single amino acid , alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
77,
87
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
90,
97
]
} |
the hemoglobin in the sheep red cells used to form rosettes was first oxidizied to the paramagnetic methemoglobin form . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
4,
14
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
100,
113
]
} |
binding of antibodies was detected with [ 125i ] staphylococcal protein a ( [ 125i ] spa ) and optimal conditions for the assay defined by varying the amounts of antibodies , bacterial antigenic targets and [ 125i ] spa . | NA | {
"id": "C0038164",
"name": "staphylococcal protein",
"pos": [
49,
71
]
} | {
"id": "C0003321",
"name": "bacterial antigenic",
"pos": [
175,
194
]
} |
stimulation of spleen cells from mice by allogeneic cells , or from tumour-bearing rats by tumour antigen consistently resulted in decreased fluorescence . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
41,
57
]
} |
an indirect rosette assay which utilizes erythrocytes coupled with purified antiimmunoglobulin ( ig ) antibodies was modified into a microassay for detecting hla allo-and xenoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
102,
112
]
} | {
"id": "C0003248",
"name": "xenoantibodies",
"pos": [
171,
185
]
} |
it inhibits the serine proteases trypsin and chymotrypsin and is antigenically related to interalpha trypsin inhibitor ( iati ) , mol wt 170,000 , a normal plasma antiprotease . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
16,
32
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
101,
108
]
} |
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