text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it inhibits the serine proteases trypsin and chymotrypsin and is antigenically related to interalpha trypsin inhibitor ( iati ) , mol wt 170,000 , a normal plasma antiprotease . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
16,
32
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
45,
57
]
} |
thus , pathogenic properties and reactive phenomenon of c. albicans are in part attributable to a cell wall polysaccharide , mannan . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
108,
122
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
125,
131
]
} |
a kinin-forming-enzyme in human skin extract was further purified by successive column chromatography on deae-cellulose , hydroxylapatite-cellulose and sepharose-4b . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
105,
119
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
138,
147
]
} |
these proteins , varying in size and molecular weight ( 6,600-2,300,000 ) were insulin , albumin , high density lipoprotein determined as apoprotein a-i , alpha 2-macroglobulin and low density lipoprotein measured as apoprotein b . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
89,
96
]
} |
these proteins , varying in size and molecular weight ( 6,600-2,300,000 ) were insulin , albumin , high density lipoprotein determined as apoprotein a-i , alpha 2-macroglobulin and low density lipoprotein measured as apoprotein b . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
217,
227
]
} |
synergy between carbenicillin and an aminoglycoside ( gentamicin or tobramycin ) against pseudomonas aeruginosa isolated from patients with endocarditis and sensitivity of isolates to normal human serum . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
37,
51
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
54,
64
]
} |
isolates from the blood of 30 patients with endocarditis due to pseudomonas aeruginosa were tested for synergy between carbenicillin and an aminoglycoside , either gentamicin or tobramycin , by in vitro checkerboard methods in modified ( cation-supplemented ) mueller-hinton broth . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
140,
154
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
164,
174
]
} |
whether given low ( 2.5 -- 5 mg/kg ) or high ( 8 mg/kg ) doses of aminoglycoside along with 30 g of carbenicillin daily , all of the five patients infected with pseudomonads that were not synergistically affected were refractory to treatment with pseudomonads that were not synergistically affected were refractory to tr... | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
66,
80
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
429,
439
]
} |
combinations of penicillin and streptomycin and penicillin and amikacin were synergistic only against those strains that were not highly resistant to streptomycin and kanamycin , respectively . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
63,
71
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
167,
176
]
} |
combinations of penicillin with kanamycin , tobramycin , sisomicin , or netilmicin failed to produce synergism against any of these strains . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
57,
66
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
72,
82
]
} |
combinations of penicillin with gentamicin or streptomycin were synergistic in the therapy of endocarditis that was produced by a strain of s. faecium that did not have a high level of resistance to aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
32,
42
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
199,
214
]
} |
combinations of penicillin with gentamicin or streptomycin were synergistic in the therapy of endocarditis that was produced by a strain of s. faecium that did not have a high level of resistance to aminoglycosides . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
46,
58
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
199,
214
]
} |
[ a case of the generalized hemangiomas who died from acute exacerbation of consumption coagulopathy in her course of nephrotic syndrome -- kasabach-merritt syndrome ( author 's transl ) ] . | NA | {
"id": "C0018916",
"name": "hemangiomas",
"pos": [
28,
39
]
} | {
"id": "C0221025",
"name": "kasabach-merritt",
"pos": [
140,
156
]
} |
the distribution and degradation of corticotrophin- ( 1 -- 24 ) -tetracosapeptide specifically labelled with tritium at tyr2 , phe7 or tyr23 and [ d-ser1 , lys17 , lys18 ] -corticotrophin- ( 1 -- 18 ) -octadecapeptide amide labelled at tyr2 were studied at various times after intravenous injection into rats . | NA | {
"id": "C0010192",
"name": "tetracosapeptide",
"pos": [
65,
81
]
} | {
"id": "C0001655",
"name": "corticotrophin",
"pos": [
173,
187
]
} |
although initially the kidneys did not clear such large amounts of peptide as did muscle and skin they played an important role by continuously and , on the basis of existing evidence , irreversibly clearing the peptides and peptide fragments from the circulation and degrading them . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
212,
220
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
225,
242
]
} |
because it is anchored at both ends , each somite cell is under tension in much the same way as a fibroblast cell in tissue culture is under tension . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
50,
54
]
} | {
"id": "C0016030",
"name": "fibroblast cell",
"pos": [
98,
113
]
} |
the dependence of antibody-and-complement-mediated lysis of virus-infected cells on the alternative pathway was examined utilizing the isolated cytolytic alternative pathway -- a system consisting of the six purified proteins of the alternative pathway of activation ( c3 , factors b and d , beta 1h , c3b inactivator an... | NA | {
"id": "C0033453",
"name": "factors b",
"pos": [
274,
283
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
404,
414
]
} |
the obligatory anion exchange is believed to be due to the permeation of electroneural ion pairs , whereas the organic cation ( r3sn+ ) has an extremely low membrane permeability . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
15,
20
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
122,
125
]
} |
when chloride was replaced by an equimolar concentration of different univalent anions in the trans compartment , the heteroexchange flux of chloride followed the sequence : i greater than br greater than cl greater than f greater than no3 . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
80,
86
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
141,
149
]
} |
when chloride was replaced by an equimolar concentration of different univalent anions in the trans compartment , the heteroexchange flux of chloride followed the sequence : i greater than br greater than cl greater than f greater than no3 . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
80,
86
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
174,
175
]
} |
when chloride was replaced by an equimolar concentration of different univalent anions in the trans compartment , the heteroexchange flux of chloride followed the sequence : i greater than br greater than cl greater than f greater than no3 . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
80,
86
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
221,
222
]
} |
there was no appreciable difference in the effectiveness of an alpha-amino acid ( alpha-alanine ) and beta-amino acid ( beta-alanine ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
88,
95
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
120,
132
]
} |
( b ) the threshold concentrations of the most potent amino acids ( arginine , glycine ) were between 10 ( -8 ) and 10 ( -9 ) m . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
54,
65
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
79,
86
]
} |
since r-proteins do not accumulate even when net rna accumulation halts , it appears that some elements of the normal , basic co-ordination between rrna and r-protein synthesis/stability persist even during relaxed control . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
49,
52
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
148,
152
]
} |
the prt of strain lt7 further differs from that of strain lt2 in that its apparent km for 5-phosphoribosylpyrophosphate is three to seven times higher when associated with anthranilate synthase in the enzyme complex which catalyses the first two steps of tryptophan biosynthesis than in its free uncomplexed form , which... | NA | {
"id": "C0003169",
"name": "anthranilate synthase",
"pos": [
172,
193
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
201,
215
]
} |
the fact that all preparations contained at least one common antigenic determinant , as judged by lines of identity to a single antiserum , is discussed in relation to antigen location . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
61,
82
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
168,
175
]
} |
the antibody described is unique among hyperimmune antisera to dna polymerases in that it recognizes only type-specific determinants on the enzyme molecule . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
51,
59
]
} |
the accumulation of dopa and 5-hydroxytryptophan after inhibition of the aromatic amino acid decarboxylase with 3-hydroxybenzylhyrazine hcl , served as a measure of catecholamine and 5-hydroxytryptamine synthesis in vivo . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
20,
24
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
165,
178
]
} |
a modification of the procedures for simultaneous radiometric determinations of plasma epinephrine ( e ) and norepinephrine ( ne ) was developed . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
109,
123
]
} |
uptake of 51cr-chromate by freshly collected human erythrocytes was inhibited by 90 mm sodium fluoride only in cells preincubated with fluoride . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
87,
102
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
135,
143
]
} |
these results suggest that the turnover of enzymes in the gut is reduced when a less digestible protein is fed , and that the endogenous pancreatic secretions and the dietary protein are not digested and absorbed as well . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
96,
103
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
167,
182
]
} |
the sbts obtained following unit does of 25 mg/kg of dicloxacillin , 35 mg/kg of penicillin , or 25 mg/kg of cephalexin with probenecid were comparable to those seen following intravenous doses of 40 mg/kg nafcillin or methicillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
81,
91
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
206,
215
]
} |
the sbts obtained following unit does of 25 mg/kg of dicloxacillin , 35 mg/kg of penicillin , or 25 mg/kg of cephalexin with probenecid were comparable to those seen following intravenous doses of 40 mg/kg nafcillin or methicillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
81,
91
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
219,
230
]
} |
the tritium was inserted at the meta position of the benzyl ring , from which it apparently does not exchange with solvent hydrogen . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
4,
11
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
123,
131
]
} |
the aluminium content of a number of proprietary antacid formulations has been determined by titration with sodium fluoride , using the fluoride activity electrode as an end-point detector . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
108,
123
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
136,
144
]
} |
the pharmacokinetics of dexamethasone alcohol is described in six male and six female healthy adult volunteers who each received 8 mg of dexamethasone phosphate by bolus intravenous injection . | NA | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
24,
37
]
} | {
"id": "C0770565",
"name": "dexamethasone",
"pos": [
137,
150
]
} |
the bioequivalence of four conjugated estrogens tablets usp was compared by measurement of seven estrogens or estrogen metabolites in the urine during steady-state dosing in postmenopausal women . | NA | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
27,
47
]
} | {
"id": "C0014939",
"name": "estrogen",
"pos": [
110,
118
]
} |
in alloxan-diabetic rats , the augmented hyperglycemic response to iso was accompanied by larger increments in plasma glucagon levels than the catecholamine produced in normal fed rats . | NA | {
"id": "C0022245",
"name": "iso",
"pos": [
67,
70
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
143,
156
]
} |
extracellular action potentials ( units ) were recorded from rat subfornical organ explants in vitro in response to addition of angiotensin ii ( aii ) or carbamyl-choline ( carbachol ) or serotonin ( 5-ht ) to the superfusion solution . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
163,
170
]
} | {
"id": "C0006945",
"name": "carbachol",
"pos": [
173,
182
]
} |
appropriate antagonists , sarc1-ala2 angiotensin ( saralasin ) for aii , atropine sulphate for carbachol and methysergide maleate for 5-ht , blocked these excitations . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
37,
48
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
67,
70
]
} |
appropriate antagonists , sarc1-ala2 angiotensin ( saralasin ) for aii , atropine sulphate for carbachol and methysergide maleate for 5-ht , blocked these excitations . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
51,
60
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
67,
70
]
} |
the distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
34,
49
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
83,
92
]
} |
the highest levels of carnitine and acetylcarnitine were found in the cauda , and spermatozoa from the proximal cauda contained significantly greater amounts of carnitine than those removed from the corpus or caput epididymidis . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
36,
51
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
161,
170
]
} |
acetylcarnitine levels ( as a % of the total carnitine pool ) were greater in all regions of the rabbit epididymis than has been reported in other species . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
0,
15
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
45,
54
]
} |
the data suggest that collagenase-like peptidase is responsible for the first , and seminal proteinase for the second , phase of human ejaculate liquefaction in vitro . | NA | {
"id": "C0030940",
"name": "peptidase",
"pos": [
39,
48
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
92,
102
]
} |
the sperm motility-stimulating activity of the smf-containing fractions was fully restored by addition of either the 'retarded ' fractions or catecholamines ( epinephrine or norepinephrine ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
159,
170
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
174,
188
]
} |
the potentiating action of catecholamines on smf was mimicked by the adrenergic agonists isoproterenol and phenylephrine and inhibited by the alpha-adrenergic antagonist phentolamine , but not by the beta-adrenergic antagonist propranolol . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
27,
41
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
89,
102
]
} |
the binding of 125i-labelled rat uterine luminal proteins from day-5 pregnant rats showed higher binding affinity to blastocysts than did the binding of proteins in uterine fluid from pro-oestrous rats ( day 0 ) , rat serum albumin ( rsa ) or bovine serum albumin ( bsa ) . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
218,
231
]
} | {
"id": "C0036774",
"name": "bovine serum albumin",
"pos": [
243,
263
]
} |
twenty-three amino acids appeared linearly in oviduct fluid to reach an average concentration 27 % of that in the plasma , with glycine and alanine present in greatest amount . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
13,
24
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
128,
135
]
} |
twenty-three amino acids appeared linearly in oviduct fluid to reach an average concentration 27 % of that in the plasma , with glycine and alanine present in greatest amount . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
13,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
140,
147
]
} |
the amounts of amino acids appearing in the oviduct lumen of rabbits injected 3 days previously with hcg were mostly similar to those of the controls , but the movements of 6 neutral amino acids appeared to be enhanced relative to their plasma concentrations following ovulation . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
15,
26
]
} | {
"id": "C0301715",
"name": "neutral",
"pos": [
175,
182
]
} |
various pgs and pg metabolites displaced [ 3h ] pgf from the receptors in the following decreasing order : pgf-2 alpha greater than 13 , 14-dihydro-pgf-2 alpha = 13,14-dihydro-15-keto pgf-2 alpha greater than pgd-2 greater than pgf-1 alpha = pge-2 greater than pge-2 beta greater than pge-1 . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
8,
10
]
} | {
"id": "C0033558",
"name": "pgd",
"pos": [
209,
212
]
} |
various pgs and pg metabolites displaced [ 3h ] pgf from the receptors in the following decreasing order : pgf-2 alpha greater than 13 , 14-dihydro-pgf-2 alpha = 13,14-dihydro-15-keto pgf-2 alpha greater than pgd-2 greater than pgf-1 alpha = pge-2 greater than pge-2 beta greater than pge-1 . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
8,
10
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
285,
288
]
} |
the concentrations of the primary prostaglandins ( pg ) f-2alpha and e-2 and the metabolite 13,14-dihydro-15-oxo-prostaglandin ( pgfm ) in maternal and fetal plasma and in allantoic fluid were measured in chronically catheterized mares and fetuses . | NA | {
"id": "C0033561",
"name": "prostaglandins",
"pos": [
34,
48
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
113,
126
]
} |
this would appear to bear out the findings of gregoziades and pampiglione ( 1966 ) that older children with this syndrome tended to have tracings similar to the normal child . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
88,
102
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
168,
173
]
} |
whereas cytidine and dthd did not reverse the inhibitory effect of 5-aza-2'-deoxycytidine , excessive doses of deoxycytidine partially reversed this inhibition . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
8,
16
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
111,
124
]
} |
similar to the depression of dthd incorporation , a depression in the incorporation of deoxycytidine and cytidine into spleen dna was found after 24-hour pretreatment with 5-aza-2'-deoxycytidine . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
87,
100
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
186,
194
]
} |
calculation of daily intake in the study region showed that the main intake of volatile nitrosamine is from ndma in beer . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
88,
99
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
108,
112
]
} |
on the contrary , the assays with s. typhimurium g46 and ta100 of bile from rats inoculated with 1,2-dimethylhydrazine , azoxymethane , or methylazoxymethanol acetate failed to reveal mutagenicity whether beta-glucuronidase was added or not , though these carcinogens were highly mutagenic for strain g46 in the salmonel... | NA | {
"id": "C0004519",
"name": "azoxymethane",
"pos": [
121,
133
]
} | {
"id": "C0025725",
"name": "methylazoxymethanol",
"pos": [
139,
158
]
} |
dipyridamole ( 20 mg/kg p.o . ) suppressed the excretion of albumin and proteins larger than albumin ( hmp ) in aminonucleoside nephrosis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
93,
100
]
} |
nucleic acid homology studies show that v. oleracea cellular dna shares similar levels of homology with dna from members of the mus and rattus genera and lower levels of homology with other rodent genera . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
0,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
104,
107
]
} |
quail embryo fibroblasts were infected at low multiplicity with avian sarcoma virus , and transformed cells were selected by their ability to form colonies in agar . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
102,
107
]
} |
the early and late gene products of human adenovirus type 12 ( ad12 ) , as well as the viral proteins synthesized in an ad12-transformed cell line , were identified by translation of viral mrna in an in vitro protein-synthesizing system . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
87,
101
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
209,
216
]
} |
in addition to the major classes of histones , several subfractions of histones h1 , h3 , and h4 were observed in acrylamide gels of proteins from sv40 virions and viral nucleoprotein complexes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
133,
141
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
170,
183
]
} |
viral dna sequences were not detected in high-molecular-weight host dna until well after the onset of viral dna replication . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
0,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
108,
111
]
} |
complementary dna corresponding to the rna genome of mouse mammary tumor virus was used to identify viral rna contained in polysomes of a virus-producing mammary tumor cell line . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
39,
42
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
100,
109
]
} |
only gp70 is accessible to lactoperoxidase-catalyzed radioiodination of fibroblasts infected by ecotropic or xenotropic virus , whereas both gp70 and the env gene polyprotein are expressed on the surface of dual-tropic mcf virus-infected cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
238,
243
]
} |
total viral polysomal polyadenylated rna was isolated from cells late after infection when such rna has sequences encoded by approximately 45 % of the hsv dna . | NA | {
"id": "C0035736",
"name": "viral",
"pos": [
6,
11
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
96,
99
]
} |
employing nick-translated radioactive viral dna purified from productively infected papillomas on cotton tail rabbits as a probe , it was found that ( i ) papillomas , primary carcinomas , and metastatic carcinomas contain 10 to about 100 copies of the viral genome per diploid cell equivalent of dna and ( ii ) viral dn... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
44,
47
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
312,
321
]
} |
these data suggest the possibility that the smaller number of internal reiterations in ebv ( w91 ) dna may be a consequence of the additional unique dna and a restriction in the overall size of ebv dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
99,
102
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
200,
201
]
} |
recoveries of mumtv proteins , based on their approximate individual contribution to total virus protein , ranged from about 20 % for gp47 to greater than 100 % for the minor structural component p23 , the major phosphoprotein of mumtv . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
20,
28
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
212,
226
]
} |
we have examined the discrete species of simian virus 40 ( sv40 ) rna present very early in infection of monkey cells with wild-type virus , with mutant tsa58 virus , and with the corresponding dnas to distinguish between two classes of models for control of late transcription : ( i ) positive control mediated by large... | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
194,
198
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
407,
416
]
} |
specific early and late viral rnas were also detected in the nuclear poly ( a ) ( + ) fractions and were similar in size to the rna species found in the cytoplasmic polyadenylated fractions . | NA | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
24,
34
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
128,
131
]
} |
in mixed infections at low multiplicities that allowed spread of progeny virus , when as little as 10 % of the virus inoculum was td virus , there was an excess of td virus by 2 days after infection and a decrease in the titer of asv relative to a control infection with no td virus . | NA | {
"id": "C0275524",
"name": "mixed infections",
"pos": [
3,
19
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
256,
265
]
} |
viral genetic information was identified by cleavage of embryo dna with restriction endonucleases , electrophoretic separation of the resulting fragments , and identification of bands containing viral sequences by hybridization of the dna to 32p-labeled viral rna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
63,
66
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
254,
259
]
} |
two new species of antigens were detected in simian virus 40-transformed mouse cells , in addition to the large ( 94,000 daltons ) and small ( 20,000 daltons ) tumor antigens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
19,
27
]
} | {
"id": "C0003335",
"name": "tumor antigens",
"pos": [
160,
174
]
} |
sequences complementary to cdna ( mc ) ( 29 ) are transcribed into approximately 10 copies per cell of polyadenylated rna in uninfected chicken fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
95,
99
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
144,
155
]
} |
whereas analysis of living , hybrid virus-infected hela cells did not yield conclusive results , analysis of formalin-fixed cells resulted in positive cell surface fluorescence with both ad2+nd1- and ad2+nd2-infected hela cells when antisera prepared against sodium dodecyl sulfate-denatured sv40 t-antigen were used as ... | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
233,
241
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
326,
334
]
} |
we analyzed the method of exhaustive hybridization of single-stranded dna and derived a general relationship between the fraction of the probe dna hybridized and the sizes and copy numbers of the segments of the viral genome integrated in cellular dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
54,
73
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
248,
251
]
} |
we analyzed the method of exhaustive hybridization of single-stranded dna and derived a general relationship between the fraction of the probe dna hybridized and the sizes and copy numbers of the segments of the viral genome integrated in cellular dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
248,
251
]
} |
this inverse relation was present in both crude and adjusted matched-pair analyses and was similar for each type of alcohol , as indicated by adjusted relative risks of 0.3 for beer , 0.3 for wine , and 0.2 for liquor . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
116,
123
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
177,
181
]
} |
this inverse relation was present in both crude and adjusted matched-pair analyses and was similar for each type of alcohol , as indicated by adjusted relative risks of 0.3 for beer , 0.3 for wine , and 0.2 for liquor . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
116,
123
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
192,
196
]
} |
since nutritional support was predominantly by routine intravenous solutions , the large amounts of urinary zinc , copper , nitrogen and potassium excreted represent a severe drain on the body 's reserves of these elements . | NA | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
124,
132
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
214,
222
]
} |
[ studies on chronic obstructive pulmonary disease by selective alveolo-bronchography ( sab ) . pulmonary emphysema lesions ( author 's transl ) ] . | NA | {
"id": "C0024117",
"name": "chronic obstructive pulmonary disease",
"pos": [
13,
50
]
} | {
"id": "C0034067",
"name": "pulmonary emphysema",
"pos": [
96,
115
]
} |
this amino acid stimulation of phospholipid biosynthesis was studied further by measuring [ 14c ] -choline accumulation and its sequential conversion to phosphorylcholine , cytidine diphosphocholine ( cdp-choline ) , and phosphatidylcholine via the kennedy pathway in regenerating renal tissue . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
99,
106
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
153,
170
]
} |
this amino acid stimulation of phospholipid biosynthesis was studied further by measuring [ 14c ] -choline accumulation and its sequential conversion to phosphorylcholine , cytidine diphosphocholine ( cdp-choline ) , and phosphatidylcholine via the kennedy pathway in regenerating renal tissue . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
99,
106
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
201,
212
]
} |
there were also increments in the vmax of the choline kinase reaction , which converts entering [ 14c ] -choline into [ 14c ] -phosphorylcholine , and of the cholinephosphotransferase reaction in which [ 14c ] -cdp-choline is incorporated into [ 14c ] -phosphatidylcholine , whereas the apparent km of each reaction was ... | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
46,
53
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
127,
144
]
} |
there were also increments in the vmax of the choline kinase reaction , which converts entering [ 14c ] -choline into [ 14c ] -phosphorylcholine , and of the cholinephosphotransferase reaction in which [ 14c ] -cdp-choline is incorporated into [ 14c ] -phosphatidylcholine , whereas the apparent km of each reaction was ... | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
46,
53
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
211,
222
]
} |
serial studies with computed tomography are likely to determine whether such demyelination precedes the growth of hamartomas and calcification that characterize tuberous sclerosis . | NA | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
114,
124
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
161,
179
]
} |
the renin-angiotensin-aldosterone axis involving the action of estrogens and progestogens on the renin substrate , plasma renin , angiotensin ii and aldosterone were analyzed . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
10,
21
]
} | {
"id": "C0003017",
"name": "renin substrate",
"pos": [
97,
112
]
} |
the renin-angiotensin-aldosterone axis involving the action of estrogens and progestogens on the renin substrate , plasma renin , angiotensin ii and aldosterone were analyzed . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
10,
21
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
130,
144
]
} |
the lipids were extracted from the lipoproteins and the triacylglycerols and cholesteryl esters separated for analysis . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
4,
10
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
35,
47
]
} |
the accumulation of 1 alpha , 25-hydroxyvitamin d3 [ 1 alpha , 25- ( oh ) 2-d3 ] in plasma produced from 25-hydroxy-vitamin d3 ( 25-oh-d3 ) was calculated from the 6-hr conversion of intravenously injected [ 3h ] -25-oh-d3 to [ 3h ] -1 alpha , 25- ( oh ) 2-d3 . | NA | {
"id": "C0006657",
"name": "25-hydroxy-vitamin d3",
"pos": [
105,
126
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
214,
222
]
} |
its genome contains a 1.1 kb substitution where mu dna from the right end of the g region has been replaced by a similar length of dna from the transposon tn3 . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
15,
16
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
total neurospora crassa dna was restricted with endonucleases and fragments carrying rrna coding sequences were identified by hybridization with xenopus laevis ribosomal dna probes . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
24,
27
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
160,
173
]
} |
sequences coding for rna ( s-rrna ) 1 of the smaller subribosomal particle were found ( at least 90 % ) in the 2.2 kbp ecori subfragment of the 5.2 kbp hind iii fragment . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
21,
24
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
29,
33
]
} |
composition of the t1-oligonucleotides was determined by digesting the t1-generated oligonucleotides with pancreatic rnase and t2-rnase . | NA | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
106,
122
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
130,
135
]
} |
the suppressed strains exhibit a partial revertant phenotype since the parental aminopterin resistance remained unchanged but the associated sensitivity to an excess concentration of the branched chain amino acids l-isoleucine , l-valine and l-leucine was diminished almost to the level of the wild-type strain c13 . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
187,
213
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
216,
226
]
} |
the suppressed strains exhibit a partial revertant phenotype since the parental aminopterin resistance remained unchanged but the associated sensitivity to an excess concentration of the branched chain amino acids l-isoleucine , l-valine and l-leucine was diminished almost to the level of the wild-type strain c13 . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
187,
213
]
} | {
"id": "C0042285",
"name": "l-valine",
"pos": [
229,
237
]
} |
the suppressed strains exhibit a partial revertant phenotype since the parental aminopterin resistance remained unchanged but the associated sensitivity to an excess concentration of the branched chain amino acids l-isoleucine , l-valine and l-leucine was diminished almost to the level of the wild-type strain c13 . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
187,
213
]
} | {
"id": "C0023401",
"name": "l-leucine",
"pos": [
242,
251
]
} |
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