text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
switching media during later passages did not reverse the shape of the cells obtained in cmrl-1066 medium or that of the fibroblast-shaped cells in ham 's f-10 medium , suggesting either that the growth of a subpopulation was favoured early during cellular adaptation to primary culture or that there was a single cell p... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
121,
131
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
314,
318
]
} |
in the plasma , however , there was small or no effect of flutamide treatment on the concentration of pregnenolone , 17-oh pregnenolone , progesterone and 17-oh-progesterone . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
102,
114
]
} | {
"id": "C0376260",
"name": "17-oh pregnenolone",
"pos": [
117,
135
]
} |
in the plasma , however , there was small or no effect of flutamide treatment on the concentration of pregnenolone , 17-oh pregnenolone , progesterone and 17-oh-progesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
138,
150
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
155,
173
]
} |
concentrations of dehydroepiandrosterone glucuronide , androst-5-ene-3 beta , 17 beta-diol glucuronide , dihydrotestosterone glucuronide , androstane-3 alpha , 17 beta-diol glucuronide and androstane-3 beta , 17 beta-diol glucuronide are 2-6-fold higher than those of the related unconjugated steroids , while testostero... | NA | {
"id": "C0002854",
"name": "androstane",
"pos": [
139,
149
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
293,
301
]
} |
the present data reveal that ( 1 ) hebm/n1 normally contains approximately 50 microm peroxides , little of which is hydrogen peroxide , ( 2 ) the organic peroxide levels accumulating in this medium are not reduced by either catalase or pyruvate , and ( 3 ) medium modifications can reduce to no longer detectable levels ... | NA | {
"id": "C0020281",
"name": "hydrogen",
"pos": [
116,
124
]
} | {
"id": "C0031180",
"name": "peroxides",
"pos": [
324,
333
]
} |
conventional neurofilament antibodies stained motor and sensory neurons in day 12 and day 13 rat embryos , respectively , as previously reported with neurofilament antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
164,
172
]
} |
the current studies were undertaken to determine whether males or neonatally testosterone-treated rats of either gender have elevated endogenous levels of ngf in the scg and one of its targets , the pineal gland . | NA | {
"id": "C0086582",
"name": "males",
"pos": [
57,
62
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
113,
119
]
} |
inoculation of wag rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum ( haptoglobin , alpha 1 acid glycoprotein , alpha 2 macroglobulin ) and in the plasma ( fibrinogen ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
155,
166
]
} |
inoculation of wag rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum ( haptoglobin , alpha 1 acid glycoprotein , alpha 2 macroglobulin ) and in the plasma ( fibrinogen ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0029297",
"name": "alpha 1 acid glycoprotein",
"pos": [
169,
194
]
} |
inoculation of wag rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum ( haptoglobin , alpha 1 acid glycoprotein , alpha 2 macroglobulin ) and in the plasma ( fibrinogen ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
119,
139
]
} | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
241,
251
]
} |
luminol-dependent chemiluminescence and thiol group oxidation of glutathione and human serum albumin were measured in order to demonstrate whether the inhibition of polymorphonuclear leukocyte chemiluminescence by albumin was attributable to thiol group oxidation . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
81,
100
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
214,
221
]
} |
there was no evidence for the development of resistance to polyenes or imidazoles in fungal isolates recovered from patients in this randomized trial or an increase in aspergillus infections in patients who received miconazole in this randomized trial or in 121 subsequently treated patients who received unblinded use o... | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
71,
81
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
322,
332
]
} |
sixteen patients ( 16 percent ) have died of the disorder , with 10 deaths due to chest wall involvement , three to spinal cord transection , two to sepsis , and one to asphyxia and aspiration . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
37,
41
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
169,
177
]
} |
dopamine , norepinephrine , serotonin and related metabolites were measured in the brain of meadow voles and mice after infection with trypanosoma brucei gambiense with the goal of understanding the neurochemical changes accompanying infection with this parasite . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
120,
129
]
} | {
"id": "C0030499",
"name": "infection",
"pos": [
234,
243
]
} |
it was completely quenched by antibodies against t-pa , but antibodies against urokinase-like plasminogen activator had no effect . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
49,
53
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
94,
115
]
} |
finally , significant patterns of gender differentiation suggested greater focal organization for affective arousal in females than males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
34,
40
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
132,
137
]
} |
reye syndrome , a reversible metabolic encephalopathy and hepatopathy , offers a unique opportunity to investigate the pharmacologic mechanisms by which a toxic-metabolic insult to mitochondria is translated into neurochemical and neurologic dysfunction . | NA | {
"id": "C0035400",
"name": "reye syndrome",
"pos": [
0,
13
]
} | {
"id": "C0006112",
"name": "metabolic encephalopathy",
"pos": [
29,
53
]
} |
[ action of calcitonin in peri- and post-menopausal osteoporosis and in osteoporosis induced by long-term treatment with cortisone ] . | NA | {
"id": "C0029458",
"name": "post-menopausal osteoporosis",
"pos": [
36,
64
]
} | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
72,
84
]
} |
low dose intra-arterial streptokinase and acylated plasminogen-streptokinase activator complex : a retrospective review of two thrombolytic regimes in recent peripheral arterial ischaemia . | NA | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
51,
62
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
63,
76
]
} |
haemodynamic and haematologic alterations with protamine reversal of anticoagulation : comparison of standard heparin and a low molecular weight heparin fragment . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
110,
117
]
} | {
"id": "C0019139",
"name": "low molecular weight",
"pos": [
124,
144
]
} |
three groups of dogs were investigated : one group received normal saline pretreatment followed by heparinisation with standard heparin 150 iu/kg followed by protamine sulfate reversal 1.5 mg/kg after aortic interposition grafting : the second group were given normal saline pretreatment followed by heparinisation with ... | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
99,
106
]
} | {
"id": "C0019139",
"name": "antixa",
"pos": [
355,
361
]
} |
the same haemodynamic changes were seen regardless of the type of heparin or pretreatment with protamine given along with low molecular weight heparin . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
66,
73
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
122,
150
]
} |
pretreatment with protamine did not abolish the adverse effects of protamine when reversing anticoagulation achieved with low molecular weight heparin , a finding not shared with standard heparin-protamine interactions . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
122,
150
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
188,
195
]
} |
holter monitoring , associated to the other cardiological screening tests , has a very important rule for diagnosis of arrhythmias or myocardial ischemia , prognostic evaluation of cardiopathic patients ( ischemic heart disease , cardiomyopathies , valvular and congenital heart disease ) , verification of the effects o... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
119,
130
]
} | {
"id": "C0018799",
"name": "cardiopathic",
"pos": [
181,
193
]
} |
we show that foetal fibroblasts secrete a migration stimulating factor ( msf ) not produced by adult cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} |
incubation of adult fibroblasts in the presence of msf induces these cells to express a foetal-like migratory phenotype . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} |
in this regard , we have shown that skin fibroblasts from cancer patients commonly express a foetal-like phenotype with respect to migratory behaviour and secretion of msf : it is of interest to note that these cancer patient fibroblasts are indistinguishable from normal adult cells in other respects , such as morpholo... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
265,
271
]
} |
the synthesis of vinculin in cultured fibroblasts increased dramatically when the cell culture density was high , concomitant with the establishment of extensive cell-substratum and cell-cell contacts of the adherens type . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
187,
191
]
} |
double label immunofluorescence observations of cryostat sections of mouse skin using the monoclonal antibodies and antibodies directed against desmoplakin , a plaque component of desmosomes , reveal that the monoclonal antibodies do not recognize certain desmosomes in basal cells which are recognized by desmoplakin an... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
101,
111
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
209,
230
]
} |
in addition , these parasympathetically denervated eyes exhibited a moderate subsensitivity to the mydriatic effects of norepinephrine , epinephrine , and isoproterenol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
120,
134
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
137,
148
]
} |
human monoclonal antibodies ( mabs ) against the o antigens of pseudomonas aeruginosa lipopolysaccharides ( lps ) were produced by cell fusion between human tonsillar lymphocytes and p3-x63-ag8-u1 ( p3u1 ) mouse myeloma cells . | NA | {
"id": "C0069180",
"name": "o antigens",
"pos": [
49,
59
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
86,
105
]
} |
in all social classes a substantial proportion of overweight people expressed a desire to reduce their weight , smokers to modify their smoking habits and sedentary people to increase the amount of exercise they took . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
50,
60
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
103,
109
]
} |
these results suggest that the antitumor cytolytic effectors generated in pbmc cultures exposed to candida material belong either to a discrete subset of natural effectors lacking classical nk markers or to other lymphokine-activated cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
74,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
cytochemical investigations revealed a dramatic decrease in the cytoplasmic content of acid phosphatase and tartrate resistant acid phosphatase in the absence of any apparent morphological modification . | NA | {
"id": "C0001109",
"name": "acid phosphatase",
"pos": [
87,
103
]
} | {
"id": "C0297331",
"name": "tartrate resistant acid phosphatase",
"pos": [
108,
143
]
} |
fever , postauricular swelling , tenderness of the ear pinna , severe otalgia and ear drainage are all typical clinical findings . | NA | {
"id": "C0013604",
"name": "swelling",
"pos": [
22,
30
]
} | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
111,
128
]
} |
[ comparative pharmacokinetic study , in the dog , of low molecular weight heparin and standard heparin by labelling with 35s ] . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
54,
82
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
96,
103
]
} |
the immobilized enzyme was made into enzyme capsules with cellulose tubing for dialysis to encapsulate it or urethane polymer to entrap it , which materials are biocompatible . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
37,
43
]
} |
the plasma and prostatic tissue concentrations of des rapidly declined from 2.3 micrograms/ml and 1.6 micrograms/g wet weight 1 h after des-dp infusion to 0.8 microgram/ml and 0.25 microgram/g wet weight 3 h after des-dp infusion , respectively , and decreased gradually thereafter until 24 h . | NA | {
"id": "C0012203",
"name": "des",
"pos": [
50,
53
]
} | {
"id": "C0060692",
"name": "infusion",
"pos": [
221,
229
]
} |
such hints that antibiotics might normally recognize rna within the ribosome , complement other data in suggesting that rna might be intimately associated with -- and , in evolutionary terms , might originally have constituted -- various functional sites within the ribosome . | NA | {
"id": "C0035701",
"name": "rna",
"pos": [
53,
56
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
120,
123
]
} |
purification and some properties of a vero toxin from escherichia coli o157 : h7 that is immunologically unrelated to shiga toxin . | NA | {
"id": "C0148323",
"name": "vero toxin",
"pos": [
38,
48
]
} | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
118,
129
]
} |
the purified vero toxin showed similar cytotoxic activity to that of shiga toxin to vero cells and killed about 50 % of the vero cells at 1 pg . | NA | {
"id": "C0148323",
"name": "vero toxin",
"pos": [
13,
23
]
} | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
69,
80
]
} |
the purified vero toxin consisted of a and b subunits with molecular weights of about 35,000 and 10,700 , respectively , which were slightly larger than those of shiga toxin . | NA | {
"id": "C0148323",
"name": "vero toxin",
"pos": [
13,
23
]
} | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
162,
173
]
} |
on polyacrylamide gel disc electrophoresis , the mobility of the purified vero toxin differed from that of shiga toxin . | NA | {
"id": "C0148323",
"name": "vero toxin",
"pos": [
74,
84
]
} | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
107,
118
]
} |
anti-vero toxin did not react with shiga toxin , and similarly anti-shiga toxin did not react with the vero toxin in either the ouchterlony double gel diffusion test or enzyme-linked immunosorbent assay . | NA | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
35,
46
]
} | {
"id": "C0148323",
"name": "vero toxin",
"pos": [
103,
113
]
} |
s. choleraesuis ( o group c1 ; o-6,7 ) and s. typhimurium [ o group b ; o- ( 1 ) ,4 ( 5 ) ,12 ] differ in o antigen of lps , determined by chromosomal locus , rfb . | NA | {
"id": "C0069180",
"name": "o antigen",
"pos": [
106,
115
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
119,
122
]
} |
the occurrence of chorea , induced by trihexyphenidyl ( benzhexol hydrochloride ) during the treatment of five adult patients who had focal or segmental dystonia , is described . | NA | {
"id": "C0041009",
"name": "trihexyphenidyl",
"pos": [
38,
53
]
} | {
"id": "C0003830",
"name": "benzhexol hydrochloride",
"pos": [
56,
79
]
} |
[ effects of bezafibrate on lipoprotein lipids and apolipoproteins b and a1 in patients with primary hypercholesterolemia ] . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
28,
39
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
40,
46
]
} |
the el strain , in which seizures are induced by repeated vestibular stimulation , had significantly lower levels of cabp in the hippocampus and dorsal occipital cortical areas than the control cf-1 strain . | NA | {
"id": "C0014544",
"name": "el",
"pos": [
4,
6
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
25,
33
]
} |
following induction of seizures in the el strain , a further decrease in cabp levels was observed in the hippocampal formation and ventral temporal cortical regions , areas where paroxysmal activity is generated in this strain . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
23,
31
]
} | {
"id": "C0014544",
"name": "el",
"pos": [
81,
83
]
} |
considering the role of cabp as an intraneuronal calcium buffer , the present findings indicate that neuronal calcium regulation is genetically altered in the el strain and is further disturbed during the events that lead to induction of seizures . | NA | {
"id": "C0014544",
"name": "el",
"pos": [
159,
161
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
238,
246
]
} |
however , clinical investigations have been hampered by the finding of intramyelin edema ( microvacuoles ) in rats and dogs . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
60,
67
]
} | {
"id": "C0013604",
"name": "edema",
"pos": [
83,
88
]
} |
microinjection of gamma-vinyl gaba ( gvg ) , a gaba elevating agent , into a discrete region of the deep prepiriform cortex elevated local gaba levels nearly 4-fold and exerted an anticonvulsant action against seizures induced by intravenous injection of the gaba antagonist , bicuculline , but was ineffective against s... | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
18,
34
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
259,
263
]
} |
contrary to a recently offered hypothesis , this sign of post-ictal depression could not be reversed by pretreatment with the morphine antagonists naloxone and naltrexone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
147,
155
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
160,
170
]
} |
prevalence and annual incidence rates of febrile seizures and types of epilepsy were investigated in all children of the altenburg district ( german democratic republic ) being 0-14 years old . | NA | {
"id": "C0009952",
"name": "febrile seizures",
"pos": [
41,
57
]
} | {
"id": "C0014544",
"name": "types",
"pos": [
62,
67
]
} |
st 587 [ 2- ( 2-chloro-5-trifluoromethylphenylimino ) imidazolidine ] , a highly alpha 1-selective agonist which easily penetrates into the brain , up to 20 mg/kg i.p . exerted no effects on the thresholds for electroshock and pentylenetetrazol-induced seizures in mice and rats , but displayed significant anticonvulsan... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
253,
261
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
351,
360
]
} |
the plasma concentrations of co-administered sodium valproate , phenytoin , carbamazepine , phenobarbitone and primidone were not altered by 1 week lamotrigine dosing . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
92,
106
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
111,
120
]
} |
elevated rdw ( greater than 15.0 % ) was observed in 90 % of id ( n = 39 ) , 32 % of acd ( n = 79 ) , 66 % of beta-thalassemia trait ( n = 100 ) , 53 % of alpha-thalassemia trait men ( n = 127 ) , 34 % of alpha-thalassemia trait women ( n = 116 ) , 3 % of sickle cell trait ( n = 101 ) , and 88 % of sickling disorders (... | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
256,
273
]
} | {
"id": "C0002895",
"name": "sickling disorders",
"pos": [
300,
318
]
} |
in plastic sections , we were able to demonstrate positive leu-m1 staining in 48 of 50 ( 96 % ) cases of acute nonlymphoid leukemia ( anl ) ( fab classification m1-m5 ) and 0 of 50 cases of acute lymphocytic leukemia ( all ) . | NA | {
"id": "C0023467",
"name": "acute nonlymphoid leukemia",
"pos": [
105,
131
]
} | {
"id": "C0023465",
"name": "fab",
"pos": [
142,
145
]
} |
ciguatera , scombroid , and paralytic shellfish poisoning account for nearly 16 per cent of all reported foodborne outbreaks of disease in the united states . | NA | {
"id": "C0008775",
"name": "ciguatera",
"pos": [
0,
9
]
} | {
"id": "C0679360",
"name": "foodborne",
"pos": [
105,
114
]
} |
polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique . | NA | {
"id": "C0034414",
"name": "quinidine",
"pos": [
40,
49
]
} | {
"id": "C0034415",
"name": "quinidine sulphate",
"pos": [
59,
77
]
} |
polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique . | NA | {
"id": "C0034414",
"name": "quinidine",
"pos": [
40,
49
]
} | {
"id": "C0034415",
"name": "quinidine sulphate",
"pos": [
59,
77
]
} |
d , l-polylactic acid ( pla ) microspheres containing quinidine base and quinidine sulphate were prepared by the solvent evaporation method . | NA | {
"id": "C0034414",
"name": "quinidine",
"pos": [
54,
63
]
} | {
"id": "C0034415",
"name": "quinidine",
"pos": [
73,
82
]
} |
neutralization and antibody-dependent enhancement of dengue infection appear to be biological outcomes of interactions between antibodies and single viral epitopes at different antibody : virus ratios . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
127,
137
]
} | {
"id": "C0003253",
"name": "viral",
"pos": [
149,
154
]
} |
all these antibodies gave some protection from infection , resulting in mortalities varying from 66 to 83 % as compared to 100 % in control rats who had received either unrelated monoclonal antibody or saline . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
10,
20
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
179,
198
]
} |
only vibriocidal protection was found to be associated with high levels of biliary iga directed against lipopolysaccharide o antigen . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
104,
122
]
} | {
"id": "C0069180",
"name": "o antigen",
"pos": [
123,
132
]
} |
intraperitoneal injection of small amounts ( 1-10 laf units ) of purified human or recombinant murine il-1 alpha ( ril-alpha ) resulted in an increased influx of inflammatory neutrophils into the peritoneal cavity that peaked at 4-14 h after il-1 injection . | NA | {
"id": "C0600251",
"name": "recombinant",
"pos": [
83,
94
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
242,
246
]
} |
our results show that striatal hypometabolism , as seen in other disorders manifesting chorea , is not the pct correlate of the dyskinesia . | NA | {
"id": "C0008489",
"name": "chorea",
"pos": [
87,
93
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
128,
138
]
} |
in addition , characterization of steroid receptors reveals that the androgen receptor , like aromatase , is present in unusually high concentrations ( 10- to 100-fold higher than in mammalian brain ) . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
34,
51
]
} | {
"id": "C0034786",
"name": "androgen receptor",
"pos": [
69,
86
]
} |
the role of the citric acid cycle in cells of the immune system and its importance in sepsis , trauma and burns . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
95,
101
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
106,
111
]
} |
the metabolic relationship between the glutamine-producing tissue and the cells of the immune system provides an explanation for some well-established changes in metabolism during the condition of surgery , trauma , sepsis and burns . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
207,
213
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
227,
232
]
} |
two main regulatory mechanisms are thought to determine the flux through the cycle : ( 1 ) regulation of individual cycle enzymes , and ( 2 ) reversible complex formation between various enzymes of the cycle and related pathways . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
122,
129
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
153,
160
]
} |
the amino-bisphosphonate apd is distinct from the bisphosphonates ehdp and cl2mdp by a greater molar potency in vivo as inhibitor of osteoclastic bone resorption and in vitro by a pronounced inhibitory effect on the accession of osteoclast precursors to mineralized matrix . | NA | {
"id": "C0043603",
"name": "bisphosphonate",
"pos": [
10,
24
]
} | {
"id": "C0012544",
"name": "bisphosphonates",
"pos": [
50,
65
]
} |
the amino-bisphosphonate apd is distinct from the bisphosphonates ehdp and cl2mdp by a greater molar potency in vivo as inhibitor of osteoclastic bone resorption and in vitro by a pronounced inhibitory effect on the accession of osteoclast precursors to mineralized matrix . | NA | {
"id": "C0012544",
"name": "bisphosphonates",
"pos": [
50,
65
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
75,
81
]
} |
ah- oxidation in the presence of dna was biphasic , showing a marked rate increase after dna was cleaved . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
33,
36
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
100,
101
]
} |
the sulfite radical anion ( so3.- ) is the first intermediate in the autoxidation of sulfite to sulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
20,
25
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
85,
92
]
} |
the sulfite radical anion ( so3.- ) is the first intermediate in the autoxidation of sulfite to sulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
20,
25
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
96,
103
]
} |
[ 3h ] thymidine dna was gamma-irradiated , digested to 2'-deoxyribonucleosides , authentic [ 14c ] ( + , - ) cis dtg added to the digestate and the mixture resolved by hplc . | NA | {
"id": "C0040077",
"name": "thymidine",
"pos": [
7,
16
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
59,
79
]
} |
a naphthalenic endoperoxide was used as a non-photochemical source of singlet oxygen ( 1o2 ) to examine some interactions between this reactive oxygen species and dna . | NA | {
"id": "C0074565",
"name": "singlet",
"pos": [
70,
77
]
} | {
"id": "C0162772",
"name": "reactive oxygen species",
"pos": [
135,
158
]
} |
without any further treatment with heat or alkali , exposure to the endoperoxide resulted in a time- and dose-dependent inactivation , ss dna being considerably more sensitive than ds dna . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
135,
141
]
} | {
"id": "C0012854",
"name": "ds",
"pos": [
181,
183
]
} |
several organophosphorus ( op ) insecticides and insect growth regulators ( igrs ) including methoprene and diflubenzuron were tested in the laboratory against c. yoshimatsui and several other midge species . | NA | {
"id": "C0022439",
"name": "insect growth regulators",
"pos": [
49,
73
]
} | {
"id": "C0025674",
"name": "methoprene",
"pos": [
93,
103
]
} |
several organophosphorus ( op ) insecticides and insect growth regulators ( igrs ) including methoprene and diflubenzuron were tested in the laboratory against c. yoshimatsui and several other midge species . | NA | {
"id": "C0022439",
"name": "insect growth regulators",
"pos": [
49,
73
]
} | {
"id": "C0012446",
"name": "diflubenzuron",
"pos": [
108,
121
]
} |
two esterase loci , est-4 and est-5 , in aedes albopictus encode carboxylesterases in 4th-instar larvae , pupae and adults . | NA | {
"id": "C0014894",
"name": "esterase",
"pos": [
4,
12
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
65,
82
]
} |
medical applications of blood compatible polyurethane elastomers contribute significantly to the quality and effectiveness of the nation 's health system . | NA | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
41,
53
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
54,
64
]
} |
[ serological diagnosis of hiv infection in subjects of high risk for aids in the city of rosario . comparative study of 3 different technics ] . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
27,
40
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
70,
74
]
} |
a case of a 48 years old man with tumoral mass localized only on a proximal jejunum loop was operated because of intestinal obstruction due to intussusception of a jejunal leiomyoblastoma . | NA | {
"id": "C0021843",
"name": "of intestinal obstruction",
"pos": [
110,
135
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
143,
158
]
} |
a brief account is given of the function of each enzyme and of the physical properties of the interacting proteins , which include albumins , lysozymes , globulins and immunoglobulins , myoglobin , transferrins , alpha-lactalbumin and melittin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
106,
114
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
131,
139
]
} |
a brief account is given of the function of each enzyme and of the physical properties of the interacting proteins , which include albumins , lysozymes , globulins and immunoglobulins , myoglobin , transferrins , alpha-lactalbumin and melittin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
106,
114
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
174,
183
]
} |
the resultant purified enzyme is a glycoprotein , has a molecular weight of approximately 80,000 ( consistent with previous reports for the bone isoenzyme ) , and is characteristically inhibited by modest heat ( 56 degrees c , 30 min ) and l-homoarginine but not by l-phenylalanine . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
23,
29
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
145,
154
]
} |
polyethylene glycol was used to induce interspecific somatic cell fusion between human fibroblasts ( stock f6 ) and drosophila melanogaster cells from established cell lines ( cl 82 and 11 p102 ) , characterized by different ploidy levels . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
87,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
140,
145
]
} |
the potential influence of these two alcohols on the inversion polymorphism of the second and fourth chromosomes was investigated in ten experimental populations with different amounts of alcohol ( either ethanol or isopropanol ) added to the culture medium . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
205,
212
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
216,
227
]
} |
these results are consistent with the interpretation that , in primates , there is not a major body pool of homovanillic acid with slow turnover , nor is metabolism to other compounds significant , nor is there evidence for nonrenal excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
154,
164
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
233,
242
]
} |
adaptive decreases in amino acids ( taurine in particular ) , creatine , and electrolytes prevent cerebral edema in chronically hyponatremic mice : rapid correction ( experimental model of central pontine myelinolysis ) causes dehydration and shrinkage of brain . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
62,
70
]
} |
severe hyponatremia and hypoosmolality induced profound decreases in levels of brain electrolytes , amino acids ( especially taurine ) , and creatine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
100,
111
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
141,
149
]
} |
correction of hyponatremia to normonatremic levels over a 9-hr period returned brain na+ and k+ levels to normal but the contents of the measured amino acids and creatine were still reduced one-third or more . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
146,
157
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
162,
170
]
} |
the findings stress the importance of amino acids ( taurine in particular ) and creatine levels , as well as electrolytes , in brain osmoregulation and suggest a role for an osmotic disequilibrium -- blood osmolality higher than brain -- in the production of brain lesions following rapid correction of chronic hyponatre... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
80,
88
]
} |
the stimulation of adenylate cyclase mechanisms requiring gtp ( gtp , forskolin , and ne ) was more susceptible than was mn2+ , suggesting that the guanine nucleotide stimulatory protein was more vulnerable to free radical attack than the catalytic site of adenylate cyclase . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
58,
61
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
148,
166
]
} |
this evidence gives further support to the possible involvement of inositol phosphates , insp3 in particular , in the aforementioned process . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
67,
86
]
} | {
"id": "C0021549",
"name": "insp3",
"pos": [
89,
94
]
} |
measurements of the kinetics of accumulation of individual [ 3h ] inositol phosphates after the addition of different ca2+-mobilizing agonists in general support the role of inositol 1,4,5-trisphosphate as the second messenger responsible for release of sequestered intracellular ca2+ . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
66,
85
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
174,
182
]
} |
contrasting properties of k+ conductances induced by baclofen and gamma-aminobutyric acid in slices of the guinea pig hippocampus . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
53,
61
]
} | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
66,
89
]
} |
properties of membrane k+ conductances induced by baclofen and gamma-aminobutyric acid ( gaba ) in the hippocampus were investigated by using guinea-pig brain slices . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
50,
58
]
} | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
63,
86
]
} |
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