text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in any cases , the most important amino acid was proline , then asparagine + glutamine group , then gamma aminobutyric acid and alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
34,
44
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
128,
135
]
} |
a comparison of complement components/albumin ratios in bal fluid with serum complement components/albumin ratios suggested a significant local production and/or concentration of these factors . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
38,
45
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
71,
76
]
} |
raynaud 's disease is a peripheral vascular system disorder characterized by episodes of vasoconstriction in the hands and feet resulting in a lowering of skin temperature and pain . | NA | {
"id": "C0034734",
"name": "raynaud 's disease",
"pos": [
0,
18
]
} | {
"id": "C0085096",
"name": "peripheral vascular",
"pos": [
24,
43
]
} |
we have previously shown that v79 multicell spheroids are resistant to the anthracenedione mitoxantrone ( 1 ) . | NA | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
75,
90
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
91,
103
]
} |
thus , the osteolysis in psoriatic arthritis also occurs in neuropathic arthritis ( e.g . syringomyelia , leprosy ) , psoriatic periosteal changes may mimic osteosarcomatous proliferations , and the calcaneal enthesitis so typical of spondylitis , reiter 's disease and psoriatic arthritis , may also be seen in metaboli... | NA | {
"id": "C0003892",
"name": "neuropathic arthritis",
"pos": [
60,
81
]
} | {
"id": "C0022408",
"name": "arthropathies",
"pos": [
322,
335
]
} |
administration of an opiate antagonist , naloxone , increases lh pulse frequency in those patients , and in patients with secondary hypothalamic amenorrhea the daily oral administration of naltrexone , another specific opiate antagonist , induces ovulatory cycles . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
41,
49
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
189,
199
]
} |
the technique is an indirect enzyme-linked assay ( elisa ) in which a fixed amount of anti-albumin antibody is placed into polystyrene tubes coated with human albumin , together with the urine sample to be tested . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
91,
98
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
153,
166
]
} |
the purpose of the present experiments was to determine the renovascular effects of the adenosine agonists n-ethyl-carboxamide adenosine ( neca ) , n6-cyclohexyl adenosine ( cha ) and 2-chloro adenosine ( 2-cla ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
88,
97
]
} | {
"id": "C0000275",
"name": "2-chloro adenosine",
"pos": [
184,
202
]
} |
pge2 infusion alone did not alter blood pressure , while it increased the urinary excretion of both epinephrine and norepinephrine , enhanced p-aminohyppuric clearance ( cpah ) , inulin clearance ( cin ) , sodium and water excretion and decreased urinary osmolality . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
100,
111
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
116,
130
]
} |
relative mobility of the main protein in the globulin fractions occurred between 0.30 and 0.40 , and dissociation was observed when the ph was increased . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
30,
37
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
45,
53
]
} |
however , nahco3 additions decreased dietary intake and at 20 g/day supplementation , apparent digestibilities of dry matter , organic matter and nitrogen were increased , but 40 g/day bicarbonate reduced these values . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
10,
16
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
185,
196
]
} |
the addition of crude fibre , especially of cellulose or lignin , reduced or prevented the anti-protozoal effects of concentrate fed ad lib . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
44,
53
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
57,
63
]
} |
[ dynamics of amino acid and protein metabolism in laying hens after the administration of 15n-labeled wheat protein . 2 . 15n excretion with nitrogen and basic amino acids of the feces ] . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
155,
172
]
} |
the labelling of the basic amino acids amounted to 13.58 atom- % for lysine , to 14.38 atom- % for histidine and to 13.63 atom- % 15n ' for arginine . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
21,
38
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
69,
75
]
} |
the labelling of the basic amino acids amounted to 13.58 atom- % for lysine , to 14.38 atom- % for histidine and to 13.63 atom- % 15n ' for arginine . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
21,
38
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
140,
148
]
} |
the average quota of the basic amino acids in the protein compounds of faeces amounts to 70.9 % for lysine 15n ' , 73.7 % for histidine 15n ' and 70.3 % for arginine 15n ' . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
25,
42
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
100,
106
]
} |
the average quota of the basic amino acids in the protein compounds of faeces amounts to 70.9 % for lysine 15n ' , 73.7 % for histidine 15n ' and 70.3 % for arginine 15n ' . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
25,
42
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
157,
165
]
} |
although most of ligands tested displaced [ 3h ] 5-ht in a manner suggestive of a single site , displacement curves for ( +/- ) -8-hydroxy-dipropylaminotetralin ( 8-oh-dpat ) , 5-methoxytryptamine , 5-methyltryptamine and 5-methoxy-n , n-dimethyltryptamine displayed non-unity hill plots , suggesting multiple site inter... | NA | {
"id": "C0036751",
"name": "5-ht",
"pos": [
49,
53
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
177,
196
]
} |
adrenaline or noradrenaline alone stimulated gluconeogenesis from lactate by 34 % both in the absence and presence of propranolol . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} |
naltrexone binds multiple opiate receptor sites in the hypothalamus , including the kappa receptors which have been implicated in appetite regulation , the use of this narcotic antagonist in hypothalamic hyperphagia appears to be a rational approach to this intractable problem . | NA | {
"id": "C0034801",
"name": "opiate receptor",
"pos": [
26,
41
]
} | {
"id": "C0064239",
"name": "kappa",
"pos": [
84,
89
]
} |
these results suggest that unique alterations in neuronal activity in several brain regions , including the traditional dopaminergic projection areas , are associated with the expression of specific da-mediated behaviors . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
120,
132
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
199,
201
]
} |
thus , it appears that this combined oral contraceptive has the promising ability to increase the anti-atherogenic hdl-cholesterol particle without altering the atherogenic ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
119,
130
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
173,
188
]
} |
[ dimensional stability of low precious metal alloys for porcelain bonding compared with a high gold alloy ] . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
46,
52
]
} | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
96,
106
]
} |
[ anti-insulin , proinsulin , pancreatic polypeptide , glucagon and somatostatin antibodies in patients with insulin-dependent diabetes mellitus treated with conventional insulin preparations ] . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0021641",
"name": "insulin preparations",
"pos": [
171,
191
]
} |
comparative analysis of two antisera , one produced in chimpanzee and another of human origin , demonstrates the existence of a spectrum of antibodies directed against at least four antigenic determinants connected with rh reactivity . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
28,
36
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
140,
150
]
} |
their destruction may contribute to the impaired recognition of soluble antigen which is one of the main features of the immune deficiency of hiv infection ( 9,13,16 ) . | NA | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
121,
138
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
142,
155
]
} |
all three polyamines - putrescine , spermidine and spermine stimulated the activity of mycobacterial rna polymerase in vitro although the concentration required for maximal stimulation was different for each of the amines . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
10,
20
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
215,
221
]
} |
the polypeptide p16 is a carboxy-terminal cleavage product of rat growth hormone in anterior pituitary and gh3 pituitary tumor cells . | NA | {
"id": "C0037663",
"name": "product",
"pos": [
51,
58
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
84,
102
]
} |
incubation of htc rat hepatoma cells with the synthetic glucocorticoid dexamethasone rapidly inhibits plasminogen activator ( pa ) activity and reveals the presence of a specific pa inhibitor ( pai-1 ) . | NA | {
"id": "C0032145",
"name": "pa inhibitor",
"pos": [
179,
191
]
} | {
"id": "C0030190",
"name": "pai-1",
"pos": [
194,
199
]
} |
blue-sensitive cone thresholds ( the ability to detect blue test lights presented on a bright yellow background ) were measured to examine foveal and central vision field sensitivity in groups of 33 glaucoma , 31 ocular hypertension ( oht ) and 24 age matched normal subjects . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
199,
207
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
213,
232
]
} |
results showed these thresholds were substantially reduced ( in all areas tested ) for the glaucoma group ( approximately 0.8 log units ) and less reduced for the oht group ( approximately 0.2 log units ) , when compared to the normal group threshold . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
91,
99
]
} | {
"id": "C0028840",
"name": "oht",
"pos": [
163,
166
]
} |
the most common eye disease are cataract , refractive error and presbyopia , and diseases of the conjunctiva and sclera . | NA | {
"id": "C0015397",
"name": "eye disease",
"pos": [
16,
27
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
43,
59
]
} |
the most common eye disease are cataract , refractive error and presbyopia , and diseases of the conjunctiva and sclera . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
43,
59
]
} | {
"id": "C0033075",
"name": "presbyopia",
"pos": [
64,
74
]
} |
the marked activity of cefuroxime , cefamandole , and cefotaxime against these organisms recommends their use in such cases . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
23,
33
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
54,
64
]
} |
[ permeability investigation of tooth root hard substance using gas forming radionuclide content . ( ii ) 2. in-vitro study with radioactive chlorine gas ] . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
64,
67
]
} | {
"id": "C0008209",
"name": "chlorine",
"pos": [
141,
149
]
} |
angiotensin ii ( 2.5 to 250nm ) induced , within 60 sec , a significant increase in [ 3h ] inositol-labeled inositol phosphate , inositol bisphosphate , and inositol trisphosphate in rat zona glomerulosa cells . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
91,
99
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
157,
165
]
} |
four strains of mice were immunized with 6 different conjugates of 3-o ( carboxymethyl-oximino ) -18-hydroxycortisol to bovine serum albumin ( 3 preparations ) , turkey serum albumin , porcine thyroglobulin , and keyhole limpet hemocyanin . | NA | {
"id": "C0036774",
"name": "bovine serum albumin",
"pos": [
120,
140
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
169,
182
]
} |
sector-like fiber necrosis , defects of the top-cell layer , new erythrocyte extravasations , beginning inflammatory reactions and ensilages of foreign bodies in the histological preparation confirm the results of the medical opinion in the acute stage until 24 hours after the trauma occurred . | NA | {
"id": "C0016542",
"name": "foreign bodies",
"pos": [
144,
158
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
278,
284
]
} |
antibody-enhanced thrombolysis : capture of tissue plasminogen activator by a bispecific antibody and direct targeting by an antifibrin-tissue plasminogen activator conjugate in vivo . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0206492",
"name": "bispecific antibody",
"pos": [
78,
97
]
} |
canine ovarian neoplasms : a clinicopathologic study of 71 cases , including histology of 12 granulosa cell tumors . | NA | {
"id": "C0919267",
"name": "ovarian neoplasms",
"pos": [
7,
24
]
} | {
"id": "C0018206",
"name": "granulosa cell tumors",
"pos": [
93,
114
]
} |
crystals in the liver were soluble in acidified ethyl alcohol , acetic acid , pyridine , chloral hydrate , and methanol , but not in xylene , petroleum ether , diethyl ether , acetone , water , or cold ethyl alcohol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
111,
119
]
} | {
"id": "C0001962",
"name": "ethyl alcohol",
"pos": [
202,
215
]
} |
since hormonal changes during gestation must affect the entire venous system , i.e. , also the arms and legs , mechanical displacement of the blood drainage pathways by the gravid uterus is most probably responsible for the significant dilatation of leg veins in the third trimester . | NA | {
"id": "C0032961",
"name": "gestation",
"pos": [
30,
39
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
267,
282
]
} |
the risk of having a fracture increases as bone mass declines , but our data suggest that bone mass is not the only factor leading to vertebral fractures in postmenopausal women . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
21,
29
]
} | {
"id": "C0080179",
"name": "vertebral",
"pos": [
134,
143
]
} |
to accomplish this purpose , the total and fractioned lipids in the liver and total lipids as well as lipoproteins in serum were determined in female wistar rats ( 120-130 g ) fed either a 5 % corn protein diet or a 20 % casein diet , with and without cocaine ( 15 mg hcl cocaine/10 g of diet ) for 18 days . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
54,
60
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
102,
114
]
} |
to accomplish this purpose , the total and fractioned lipids in the liver and total lipids as well as lipoproteins in serum were determined in female wistar rats ( 120-130 g ) fed either a 5 % corn protein diet or a 20 % casein diet , with and without cocaine ( 15 mg hcl cocaine/10 g of diet ) for 18 days . | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
252,
259
]
} | {
"id": "C0282108",
"name": "hcl cocaine",
"pos": [
268,
279
]
} |
all treatments were then subjected to the following determinations : ph , moisture , crude protein , ammonia n , ashes , cellular walls , hemicellulose , cellulose , lignin , silica , gross energy , and dry matter in vitro digestibility . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
142,
151
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
166,
172
]
} |
[ allergic mouth diseases . 2. short analysis of the main dental materials showing allergenicity . 2. chrome-cobalt alloys ; nickel-chromium alloys ; gold alloys ; elastic impression materials ; orthodontic materials ; periodontal and antiseptic ] . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
116,
122
]
} | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
150,
161
]
} |
in any case of blunt trauma , although one eye may have more obvious signs of injury , an extensive examination of the fellow eye must always be included because less severe trauma may have resulted in serious injuries that can go undetected . | NA | {
"id": "C0043253",
"name": "blunt trauma",
"pos": [
15,
27
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
174,
180
]
} |
two aminoglycosides , gentamicin and netilmycin were given to rats either in low doses equivalent to those used clinically ( bg4 and bn5 groups ) or in doses ten times higher ( bg40 and bn50 ) . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
4,
19
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
22,
32
]
} |
the phenomenon appears to be unique among animals . beta-chain sequencing determinations show that abnormal human hemoglobin with similar properties has a glutamic acid residue substituted at the alpha 1-beta 2 interface by valine in snake hemoglobin . | NA | {
"id": "C0019047",
"name": "abnormal",
"pos": [
99,
107
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
240,
250
]
} |
the extrusion of accumulating anions , such as lactate ions , from the myocardium is one mechanism for the early potassium loss during hypoxia . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
30,
36
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
55,
59
]
} |
coronary sinus blood noradrenaline and adrenaline concentrations rose significantly ( p less than 0.01 ) from 58 ( 44-87 ) pg.ml-1 at control to 2208 ( 1159-5627 ) pg.ml-1 at peak uptake and from 15 ( 11-19 ) pg.ml-1 to 85 ( 64-230 ) pg.ml-1 respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
21,
34
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
39,
49
]
} |
arterial noradrenaline increased from 29 ( 19-41 ) pg.ml-1 to 374 ( 176-640 ) pg.ml-1 and arterial adrenaline rose from 15 ( 11-23 ) pg.ml-1 to 31 ( 24-52 ) pg.ml-1 ( p less than 0.001 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
9,
22
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
99,
109
]
} |
this study was designed to evaluate the long-term effect ( 6 months ) of the luteinizing hormone-releasing hormone ( lh-rh ) agonist buserelin on pituitary and ovarian function in a group of 14 patients presenting with the polycystic ovarian ( pco ) syndrome . | NA | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
117,
122
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
133,
142
]
} |
apart from the presence of pericardial effusion in 6 per cent and minor abnormalities of the e-f slope in 5 per cent of patients , all the other significant echocardiographic abnormalities could be related to the presence of associated cardiac disease . | NA | {
"id": "C0031039",
"name": "pericardial effusion",
"pos": [
27,
47
]
} | {
"id": "C0018799",
"name": "the",
"pos": [
209,
212
]
} |
in the present experiments , we studied the subcellular distribution of three types of extralysosomal , neutral proteolytic activities in rat telencephalon : ( 1 ) nonthiol proteases ( ntp ) , ( 2 ) thiol proteases ( tp ) , and ( 3 ) calcium-activated thiol proteases ( calpains i and ii ) . | NA | {
"id": "C0010661",
"name": "thiol proteases",
"pos": [
167,
182
]
} | {
"id": "C0006784",
"name": "calcium-activated",
"pos": [
234,
251
]
} |
serum 25-hydroxycholecalciferol ( 25- ( oh ) d3 ) , calcium and albumin have been measured in 27 patients undergoing treatment for pulmonary tuberculosis . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
6,
31
]
} | {
"id": "C2713074",
"name": "25",
"pos": [
34,
36
]
} |
studies of the effects of acidosis and dietary calcium on 25-hydroxyvitamin d3 ( 25ohd3 ) metabolism were conducted utilizing assays of mitochondrial 1-hydroxylase and 24-hydroxylase activity following 96 hours of acid loading . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
58,
78
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
81,
87
]
} |
a comparative immunocytochemical study on the subcellular distributions of 44 kda bone phosphoprotein and bone gamma-carboxyglutamic acid ( gla ) -containing protein in osteoblasts . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
87,
101
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} |
bone gamma-carboxyglutamic acid ( gla ) -containing protein ( bgp or osteocalcin ) and 44 kda bone phosphoprotein ( 44k bpp , also called sialoprotein i or osteopontin ) have been localized at the ultrastructural level in osteoblasts from woven bones of newborn rats . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
99,
113
]
} |
like pdgf , hep i is active in a wide variety of mesenchyme-derived cells , including osteoblasts , chondrocytes , smooth muscle cells , fibroblasts , 3t3 cells and nrk cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
100,
112
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
169,
174
]
} |
like pdgf , hep i is active in a wide variety of mesenchyme-derived cells , including osteoblasts , chondrocytes , smooth muscle cells , fibroblasts , 3t3 cells and nrk cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
137,
148
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
169,
174
]
} |
the second factor , hep ii , has an approximate molecular weight of 20,000 daltons and possesses substantial mitogenic activity for osteoblasts , chondrocytes , and smooth muscle cells , but is not mitogenic for fibroblasts , 3t3 cells , and nrk cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
146,
158
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
246,
251
]
} |
we suggested that aluminum induces rickets in growing uremic rats , which consists of two components : vitamin d refractory osteomalacia and 1 alpha,25 ( oh ) 2d3-dependent epiphyseal growth plate changes . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
35,
42
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
124,
136
]
} |
the following determinations were carried out in serum : gamma-glutamyl transferase , aminotransferases , alkaline phosphatase and its placental isoform , haptoglobin , protein- and lipid-bound sialic acid . | NA | {
"id": "C0597298",
"name": "isoform",
"pos": [
145,
152
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
169,
176
]
} |
this compound was converted by reaction with appropriate amine into amides and anilides of beta-/p-chlorobenzoyl/-acrylic acid ( 3-10 ) . | NA | {
"id": "C0002482",
"name": "amides",
"pos": [
68,
74
]
} | {
"id": "C0003035",
"name": "anilides",
"pos": [
79,
87
]
} |
the levels of malondialdehyde ( mda ) as an indication of the degree of peroxidation and lipids ( cholesterol , triglyceride , separation of lipoproteins into fractions ) were measured . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
89,
95
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
141,
153
]
} |
narcotic addict patients do have detectable 7s platelet antibody but also appear to have immune complex deposition on their platelets , possibly due to anti-f ( ab ' ) 2 antibodies . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
89,
103
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
170,
180
]
} |
furthermore , monoclonal antibodies that identify b cells such as the anti-b1 and anti-b4 antibodies in combination with studies of immunoglobulin gene rearrangement have demonstrated that virtually all cases of non-t-all involve b lymphocytes . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
14,
24
]
} | {
"id": "C0768182",
"name": "anti-b1",
"pos": [
70,
77
]
} |
the lymphoma data is described which may suggest a useful role of high dose therapy with abmt in relapsed disease-timing of abmt may need to differ profoundly in hd from nhl . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
4,
12
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
170,
173
]
} |
there is evidence suggesting that the frequency of fatal pulmonary embolism can be reduced by such prophylactic remedies as low-dose heparin , dextran , the combination of dihydroergotamine plus heparin , and low molecular weight heparin . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
133,
140
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
209,
237
]
} |
of the parasitic helminths that take up free cobalamins in vitro , all but one species showed no uptake of cobalamin bound to transport proteins , although the latter type of cobalamin by far predominates in vivo . | NA | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
45,
55
]
} | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
175,
184
]
} |
fmc27 and fmc8 recognise different epitopes , and fmc27 may thus be used in a cocktail together with fmc8 and an antibody against the c-all antigen , wm21 . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
35,
43
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
140,
147
]
} |
the basal activity of 2-5 a synthetase in pbmc from patients without gvhd could not be stimulated , during the first 3 months after bmt , by the cultivation of cells with ifn alpha . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
42,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
160,
165
]
} |
in contrast , a strong generation of allogeneic cytotoxic cells , assessed by the number of lytic units per 10 ( 6 ) cells , was frequently found ( 18/38 patients tested in both groups ) in the first 4 months , despite the quantitative deficit of the cd4+ subset . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
37,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} |
marrow cell suspensions , hl-60 cells and trypsin-dispersed fibroblasts were irradiated at 5 or 45 cgy/min and then assayed for cfc . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cfc",
"pos": [
128,
131
]
} |
selection of an intravenous immune globulin for the immunoprophylaxis of cytomegalovirus infections : an in vitro comparison of currently available and previously effective immune globulins . | NA | {
"id": "C0085297",
"name": "intravenous immune globulin",
"pos": [
16,
43
]
} | {
"id": "C0021027",
"name": "immune globulins",
"pos": [
173,
189
]
} |
catecholamines ( norepinephrine , epinephrine , and dopamine ) are released into circulation in response to stress and injury and as part of the body 's attempt at vasoregulation in response to circulatory failure . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
17,
31
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
34,
45
]
} |
norepinephrine is released from sympathetic nerve terminal , and epinephrine and dopamine are released from the adrenal medulla . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} |
studies with three interferon molecules , ifn-alpha 2 , ifn-beta 1 , and a `` '' hybrid '' '' interferon , ifnx-430 are described which illustrate that both the expression and secretion characteristics of heterologous proteins in yeast cells reflect properties of the proteins themselves . | NA | {
"id": "C0021734",
"name": "ifn-alpha 2",
"pos": [
42,
53
]
} | {
"id": "C0021747",
"name": "interfer",
"pos": [
19,
27
]
} |
neomycin resistant transformants could be selected for on complete medium containing 1.2 mg/ml neomycin sulfate . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
0,
8
]
} | {
"id": "C0027607",
"name": "neomycin sulfate",
"pos": [
95,
111
]
} |
while the levels of catecholaminergic and dopaminergic markers were reduced significantly at late gestational ages , the relative rate of turnover of dopamine ( da ) , measured by the ratio of dopac/da , was elevated significantly in ts19 mice . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
42,
54
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
199,
201
]
} |
fmc7 , a monoclonal antibody used extensively to characterize b cell leukaemias of differentiated phenotype ( prolymphocytic , hairy cell , and similar leukaemias ) was compared directly with antibodies of the cd22 cluster , which also react with b cells at a late stage in differentiation . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
9,
28
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
192,
202
]
} |
in addition , there was no difference in the neurofilament protein response from pc12 cells that had been treated with ngf prior to coculture , and the now primed pc12 cells readily extended axons over fibroblast monolayers . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
202,
212
]
} |
carotid body tumours , or chemodectomas , can occur on both sides of the neck ( 5 % ) , and this bilaterality increases sixfold ( 30 % ) where a familial pattern is evident . | NA | {
"id": "C0007279",
"name": "carotid body tumours",
"pos": [
0,
20
]
} | {
"id": "C0030422",
"name": "chemodectomas",
"pos": [
26,
39
]
} |
two main cell types were present -- fusiform chondrocytes lying in swirling patterns were the predominant cell type of the cartilage up to and including two years , while a more rounded cell , randomly arranged , was commoner in the older specimens . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
45,
57
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
186,
190
]
} |
evidence suggests that these cells represent two distinct populations of chondrocyte , the round cells being derived from the earlier fusiform cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
73,
84
]
} |
this response was specific to these mab and was not found with several other mab restricted to myelomonocytic cells but with other antigenic epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
131,
140
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
141,
149
]
} |
a mixture of glycosaminoglycans lyases from heparin-induced flavobacterium heparinum removed 80 % of the [ 35s ] sulphate-labelled glycosaminoglycans from the surface of attached cells within 30 min , but this had little effect on cell morphology . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
44,
51
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
131,
149
]
} |
experimental support for this suggestion was obtained by the substitution of choline chloride for sodium chloride in the perfusing medium , which can be done without altering the osmotic strength of the perfusing medium . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
85,
93
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
98,
113
]
} |
narcolepsy is characterized by periods of irresistible sleepiness and sleep attacks of brief duration and , most often , by one or more of the auxiliary symptoms : cataplexy , sleep paralysis , and hypnogogic hallucinations . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
0,
10
]
} | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
164,
173
]
} |
for cataplexy and the other two auxiliary symptoms of narcolepsy , imipramine or other tricyclics are the drugs of choice . | NA | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
4,
13
]
} | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
54,
64
]
} |
in case 1 , the large and small gallstones differed in buoyancy , and ursodeoxycholic acid treatment dissolved the floating small stones while failing to dissolve the nonfloating large stone . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
32,
42
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
185,
190
]
} |
in ha-1 fibroblasts , for instance , over 99 % of cells are killed by 45 degrees c heat before a decrease is observed in any parameter of energy status . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
8,
19
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} |
one should recognize that global measures of change , such as the ratio of unsaturated to saturated fatty acids , in unsaturated fatty acid index , or percentage of unsaturated fatty acids , may not accurately reflect changes in fatty acid patterns which are related to changes in thermosensitivity . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
165,
188
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
229,
239
]
} |
4-en compounds such as testosterone , progesterone , 17 alpha-oh-progesterone , and corticosteroids were the lower in potency . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
38,
50
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
53,
55
]
} |
the agonist and antagonist tested act on cardiac plasma membrane beta receptors and their actions modify transmembrane calcium fluxes , so that the present study shows that chagas ' disease modifies the normal behavior of adrenergic beta cardiac receptors in different degree depending on the stage of the trypanosomiasi... | NA | {
"id": "C0041234",
"name": "chagas",
"pos": [
173,
179
]
} | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
306,
321
]
} |
monolayer cell cultures of female rat anterior pituitaries were used to investigate the effect of leukotrienes ( lt ) lta4 , ltb4 , ltc4 , ltd4 , lte4 and other lipoxygenase metabolites of arachidonic acid ( 5-hete , 5-hpete , and 15-hete ) in vitro . | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
98,
110
]
} | {
"id": "C0125631",
"name": "lta4",
"pos": [
118,
122
]
} |
cells cultured in ham 's f-10 medium containing 10 % fbs showed the typical fibroblastic morphology at confluence ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
76,
88
]
} |
in about 50 % of the cultures in cmrl-1066 medium we observed fibroblast-shaped cells that superficially resembled cells grown in ham 's f-10 medium , but were able to form dome structures . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
62,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
115,
120
]
} |
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