text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
of the latter , 3 had kartagener 's syndrome , one had kartagener 's forme fruste , and 3 had bronchiectasis and sinusitis . | NA | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
22,
44
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
94,
108
]
} |
[ comparison of bactericidal effects of four aminoglycoside antibiotics : amikacin , gentamicin , kanamycin and tobramycin ( author 's transl ) ] . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
74,
82
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
98,
107
]
} |
the authors have studied on 20 bacterial strains ( 5 pseudomonas aeruginosa , 5 escherichia coli , 5 klebsiella and 5 serratia ) the bactericidal kinetics of 4 aminoglycoside antibiotics : amikacin , gentamicin , kanamycin and tobramycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
189,
197
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
213,
222
]
} |
in proctological practice , contact dermatitis by sensitivity to anaesthetics or suppository balsams ( peruvian balsam ) , itching or burning atrophy by topical steroid abuse , non-diagnosed fungal ( candidiasis ) , bacterial ( erythrasma ) or psoriatic intertrigos ( flexural psoriasis ) may sometimes explain the failu... | NA | {
"id": "C0004714",
"name": "balsams",
"pos": [
93,
100
]
} | {
"id": "C0070477",
"name": "peruvian balsam",
"pos": [
103,
118
]
} |
electron microscopical study indicates : -- numerous intracytoplasmic lipid inclusions of various type ( droplets , crystals , concentric lamellar bodies , ceroid granules ) in dermal cells ( histiocytic foam cells , endothelial cells , schwann cells , fibroblasts and most cells ) ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
253,
264
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
274,
279
]
} |
this problem is all the more important as in this observation xanthomatosis was first with a normal lipidic measurement , lipidic disorders appearing only secondarily . | NA | {
"id": "C0043325",
"name": "xanthomatosis",
"pos": [
62,
75
]
} | {
"id": "C0154251",
"name": "lipidic disorders",
"pos": [
122,
139
]
} |
the major problem area in the diagnosis of thyroid cancer by large needle biopsy is in the identification of follicular carcinoma and the follicular variant of papillary carcinoma . | NA | {
"id": "C0206682",
"name": "follicular carcinoma",
"pos": [
109,
129
]
} | {
"id": "C0206683",
"name": "follicular variant",
"pos": [
138,
156
]
} |
the rate of ampicillin transfer into solution from suspensions of 2 types , i.e . suspensions of anhydrous ampicillin and suspensions of ampicillin trihydrate was studied . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
12,
22
]
} | {
"id": "C0700443",
"name": "ampicillin trihydrate",
"pos": [
137,
158
]
} |
definite advantages of the anhydrous ampicillin suspension were shown as compared to the ampicillin trihydrate suspension . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
37,
47
]
} | {
"id": "C0700443",
"name": "ampicillin trihydrate",
"pos": [
89,
110
]
} |
high efficacy of prodigiozan , a bacterial polysaccharide used in the form of inhalation in combined therapy of 123 children at the age of 3 to 14 with nonspecific bronchopulmonary pathologic conditions was shown . | NA | {
"id": "C0033260",
"name": "prodigiozan",
"pos": [
17,
28
]
} | {
"id": "C0032595",
"name": "bacterial polysaccharide",
"pos": [
33,
57
]
} |
the in vitro activities of the new ureidopenicillins piperacillin , mezlocillin , azlocillin , and bay k 4999 were compared with those of ampicillin and ticarcillin against 336 enterobacteriaceae , 109 nonfermenters , 55 neisseria , and 28 haemophilus influenzae isolates . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
53,
65
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
the in vitro activities of the new ureidopenicillins piperacillin , mezlocillin , azlocillin , and bay k 4999 were compared with those of ampicillin and ticarcillin against 336 enterobacteriaceae , 109 nonfermenters , 55 neisseria , and 28 haemophilus influenzae isolates . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
68,
79
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
the in vitro activities of the new ureidopenicillins piperacillin , mezlocillin , azlocillin , and bay k 4999 were compared with those of ampicillin and ticarcillin against 336 enterobacteriaceae , 109 nonfermenters , 55 neisseria , and 28 haemophilus influenzae isolates . | NA | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
82,
92
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
the in vitro activity of ( 6r,7r ) -7- { [ carboxy ( 4-hydroxyphenyl ) acetyl ] amino } -7-methoxy-3- [ [ ( 1-methyl -1h-tetrazol-5-yl ) thio ] methyl ] -8-oxo-5-oxa-1-azabicyclo- [ 4.2.0 ] oct-2-ene -2-carboxylic acid was tested against isolates of gram-positive and negative bacteria and compared with those of cephalo... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
327,
337
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
366,
376
]
} |
the in vitro activity and beta-lactamase stability of 7- [ d ( - ) -alpha- ( 4-ethyl-2,3-dioxopiperazino-carbonylamino ) -p-hydroxyphenylacetamido ] -3- [ ( 1-methyl ) -5-tetrazolylthiomethyl ] -delta ( 3 ) -cephem-4-carboxylic acid ( cefoperazone ) , a cephalosporin analog of piperacillin , were compared with the acti... | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
352,
366
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
371,
382
]
} |
cefoxitin , a parenteral cephamycin beta-lactam antibiotic , was evaluated for safety and efficacy in children with bacterial infections other than meningitis . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
25,
35
]
} |
the nucleic acid was found to be deoxyribonucleic acid and contained an unusual base which substituted for 35 % of the guanine . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "deoxyribonucleic acid",
"pos": [
33,
54
]
} |
bacteria able to utilize aspon , azodrin , dasanit , diazinon , malathion , orthene , parathion , trithion , dimethoate , dylox , methyl parathion , and vapona as sole phosphorus sources were isolated from soil and sewage . | NA | {
"id": "C0030514",
"name": "parathion",
"pos": [
86,
95
]
} | {
"id": "C0025709",
"name": "methyl parathion",
"pos": [
130,
146
]
} |
extracts of the two bacteria derived from organophosphate-grown cultures catalyzed the disappearance of aspon , azodrin , dasanit , diazinon , malathion , orthene , parathion , and trithion but not dimethoate , dylox , methyl parathion , and vapona . | NA | {
"id": "C0030514",
"name": "parathion",
"pos": [
165,
174
]
} | {
"id": "C0025709",
"name": "methyl parathion",
"pos": [
219,
235
]
} |
the whole-cell penicillin amidohydrolase from m. luteus was capable of hydrolyzing penicillin g , penicillin v , ampicillin , and cephalexin , but not cephalosporin c and cloxacillin . | NA | {
"id": "C0030827",
"name": "penicillin",
"pos": [
15,
25
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
113,
123
]
} |
from comparisons of 4 % n-z amine nak made with distilled water , naturally hard water , and synthetic salt solutions , it appeared that magnesium and , to a lesser extent , iron were limiting factors in the production of staphylococcal enterotoxins b and c but not a . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
48,
63
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
81,
86
]
} |
experiments with [ 1- ( 14 ) c ] arabinose indicated that pentose was fermented by a pentose phosphate cycle plus glycolysis , with some indication of a minor phosphoketolase-type pathway . | NA | {
"id": "C0003682",
"name": "arabinose",
"pos": [
33,
42
]
} | {
"id": "C0030894",
"name": "pentose",
"pos": [
85,
92
]
} |
it is accompanied by increased hyaluronic acid secretion and is induced by agents that enhance intracellular activity of cyclic adenosine monophosphate , such as dibutyryl cyclic adenosine monophosphate and cholera enterotoxin . | NA | {
"id": "C0001455",
"name": "cyclic adenosine monophosphate",
"pos": [
121,
151
]
} | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
162,
171
]
} |
some in-vitro effects of the arthritogenic polysaccharide carrageenin were studied on cells from human synovium . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
43,
57
]
} | {
"id": "C0007289",
"name": "carrageenin",
"pos": [
58,
69
]
} |
a marked increase in lymphocytes lacking both t and b cell markers was observed , which may be related to an increase in precursors of mature cells or to a masking of receptors on the membrane of lymphocytes , but which is probably independent of an increase in the number of k cells , since cells bearing receptors for ... | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
121,
131
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
292,
297
]
} |
since no parathyroids were removed in the patients with graves ' disease , and since branches of the inferior thyroid artery were invariably ligated distal to the parathyroids , we hypothesized that the late hypocalcemia might be associated with a peculiarity in scar formation in the presence of this autoimmune disease... | NA | {
"id": "C0018213",
"name": "graves",
"pos": [
56,
62
]
} | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
302,
320
]
} |
single doses of 4.5 mg/kg of the opiate agonist , morphine , the partial agonists , cyclazocine , pentazocine , levallorphan and nalorphine , the antagonists , naloxone and naltrexone and dextrorphan were injected i.p . in groups of rats . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
160,
168
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
173,
183
]
} |
the results suggest that dobutamine differs from other catecholamines in its mode of action and that its cardiovascular actions may be mediated in part through an indirect action on adrenoceptors . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
25,
35
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
55,
69
]
} |
the absorption , tissue distribution , metabolism and excretion of 14c-metronidazole ( 14c-mtz ) were compared during the first 24 hr upon the intravaginal ( ivg ) administration of 14c-mtz , either as a single product ( ivg-sp ) or as a formulation in the form of a commercial cream ( ivg-cp ) . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
39,
49
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
54,
63
]
} |
adrenaline , noradrenaline and isoprenaline produced dose-related contractions in the common portion of the coronary artery which were blocked by phenoxybenzamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
the proximal portions were relaxed by noradrenaline and isoprenaline , but contracted or relaxed by adrenaline following an initial transient contraction . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
100,
110
]
} |
adrenaline , noradrenaline and isoprenaline caused only relaxations which were blocked by propranolol in the distal portion and in the small branches . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
the pharmacologically active peptides bradykinin ( bk ) lysylbradykinin or kallidin ( lbk ) and methionyl-lysylbradykinin ( mlbk ) were shown to react with pyridoxal-5'-phosphate ( plp ) forming schiff bases ; | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
38,
48
]
} | {
"id": "C0022474",
"name": "lysylbradykinin",
"pos": [
106,
121
]
} |
upon reduction with sodium borohydride they were transformed into stable phosphopyridoxyl-kinins ( pp-bk , pp-lbk and pp-mlbk ) . | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
90,
96
]
} | {
"id": "C0006100",
"name": "bk",
"pos": [
123,
125
]
} |
upon reduction with sodium borohydride they were transformed into stable phosphopyridoxyl-kinins ( pp-bk , pp-lbk and pp-mlbk ) . | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
102,
104
]
} | {
"id": "C0022474",
"name": "mlbk",
"pos": [
121,
125
]
} |
amino acid analysis showed that the n-terminal alpha-aminogroup of the three kinins were efficiently blocked by phosphopyridoxyl groups : 98.8 % for bk ; | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
77,
83
]
} | {
"id": "C0006100",
"name": "bk",
"pos": [
149,
151
]
} |
estimated by guinea-pig ileum and the vascular permeability of rat skin assays respectively- the pp-kinins had the following average activities compared to the respective kinins : pp-bk , 0.20 and 0.16 ; | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
100,
106
]
} | {
"id": "C0006100",
"name": "bk",
"pos": [
183,
185
]
} |
signs and symptoms of hypocalcemia consisted of tetany ( chvostek 's and trousseau 's signs ) , seizures , diminshed to absent deep tendon reflexes , papilledema , mental changes ( weakness , fatigue , irritability , memory loss , confusion , delusion , hallucination ) , and skin changes . | NA | {
"id": "C0020598",
"name": "hypocalcemia",
"pos": [
22,
34
]
} | {
"id": "C0039621",
"name": "tetany",
"pos": [
48,
54
]
} |
the analysis of the autographs demonstrated that during wound healing the cell-precursors of macrophages and fibroblasts migrate from beyond the limits of the connective tissue . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
70,
78
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} |
it was stated that intensity of chondrogenesis and growth of bones are affected by several processes : intensity of chondrocyte multiplication , the rate of their repeated division in the proliferative zone , the velosity with which the cells transfer into the state of hypertrophy and the rate of the periostal bone for... | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
116,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
237,
242
]
} |
the data from the literature and the authors ' own studies on changes in the lungs in systemic diseases of the connective tissue with immune disorders : systemic lupus erythematosus , progressive systemic sclerosis , rheumatoid arthritis , and periarteriitis nodosum are presented . | NA | {
"id": "C0009782",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0036421",
"name": "progressive systemic sclerosis",
"pos": [
184,
214
]
} |
to investigate further the role of growth hormone ( gh ) on the cerebral effects of levodopa , human somatotropin ( human growth hormone ) was administered to four patients with parkinsonism with varying response to chronic levodopa therapy . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
35,
49
]
} | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
116,
136
]
} |
we conclude that neither the endogenous increases of gh in response to levodopa nor those attained following human somatotropin administration modify in any consistent way the therapeutic and side effects of chronic levodopa therapy , and that the episodic releases of gh in response to levodopa occur independently of i... | NA | {
"id": "C0169964",
"name": "human",
"pos": [
109,
114
]
} | {
"id": "C0037663",
"name": "gh",
"pos": [
269,
271
]
} |
a patient with severe narcolepsy and cataplexy had been treated with a high dosage of methylphenidate hydrochloride , but the drug was not effective . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
22,
32
]
} | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
37,
46
]
} |
dipivefrin produced similar percent reductions in intraocular pressure ( 18.6 % ) to epinephrine ( 21.0 % ) , as well as similar increases in outflow facility and pupil diameter . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
0,
10
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
85,
96
]
} |
this study supported the contention that dipivefrin is an effective and safe alternative to epinephrine therapy for the reduction of elevated intraocular pressure . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
41,
51
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
92,
103
]
} |
a study was undertaken to determine whether the antiesterase activity of echothiophate iodide would prevent the conversion of dipivefrin to epinephrine . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
126,
136
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} |
addition of epinephrine to eyes receiving dipivefrin plus echothiophate resulted in a significant additional decrease in iop of 4 +/- 1 mm hg ( p less than .001 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
42,
52
]
} |
these results fit the theory that the esterase converting dipivefrin to epinephrine is inactivated by cholinesterase inhibitors . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
58,
68
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} |
it was demonstrated that secretory otitis may develop without a preceding infection of the middle ear . | NA | {
"id": "C0029877",
"name": "otitis",
"pos": [
35,
41
]
} | {
"id": "C0029882",
"name": "infection",
"pos": [
74,
83
]
} |
the following aminoglycoside antibiotics netilmicin , sisomicin , gentamicin , and kanamycin were submitted to a comparative study of their ototoxicity using both reflexological ( preyer 's pinnareflex ) and electrophysiological ( near and far field ) methods . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
41,
51
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
54,
63
]
} |
the following aminoglycoside antibiotics netilmicin , sisomicin , gentamicin , and kanamycin were submitted to a comparative study of their ototoxicity using both reflexological ( preyer 's pinnareflex ) and electrophysiological ( near and far field ) methods . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
54,
63
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
66,
76
]
} |
the daily s.c. administration of sisomicin , gentamicin , and kanamycin for 21 days provoked a dose-related impairment of the cochlear function , detected with all the employed techniques . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
33,
42
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
45,
55
]
} |
in seven human melanoma cell lines and one human fibroblast strain some correlation of resistance to cell killing was found with two bifunctional alkylating agents ( melphalan , chlorambucil ) and three monofunctional agents ( 4 ( 5 ) - ( 3,3-dimethyl-l-triazeno ) imidazole-5 ( 4 ) -carboxamide ( dtic ) , methylmethane... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
49,
59
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
101,
105
]
} |
inhibition of tamm-horsfall glycoprotein induction of alkaline phosphatase in cystic fibrosis fibroblasts by medium conditioned by normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
the enzymic removal of sialic acid residues from the glycoproteins of the human erythrocyte decreases the solubilization of membrane glycoprotein by triton x-100 . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
53,
66
]
} | {
"id": "C0025248",
"name": "membrane glycoprotein",
"pos": [
124,
145
]
} |
from the amount of actin-derived peptides present , the actin content of imr-90 fibroblasts was calculated to be 4.2 % of the total protein of these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
149,
154
]
} |
glycophorin prepared by a lithium di-iodosalicylate-extraction/phenol-partition method was rich in polyphosphoinositides ( phosphatidyl-myo-inositol 4-phosphate and phosphatidyl-myo-inositol 4,5-bisphosphate ) , but glycophorin extracted by triton x-100 showed no such enrichment . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
99,
120
]
} | {
"id": "C0031621",
"name": "phosphatidyl-myo-inositol",
"pos": [
165,
190
]
} |
disposable pipette tips made of polymeric nylon tube with enzymes bound covalently to their inside surface and fixed to the stem of an automatic , adjustable-volume pipette holder together constitutes an immobilized enzyme pipette or 'impette ' . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
58,
65
]
} | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
204,
222
]
} |
the purified membranes were essentially free of l-alanine-alpha-oxoglutarate aminotransferase , l-asparte-alpha-oxoglutarate aminotransferase , malate dehydrogenase , oligomycin-sensitive adenosine triphosphatase , glucose 6-phosphatase , mg2+-stimulated p-nitrophenyl phosphatase and catalase . | NA | {
"id": "C0001899",
"name": "alanine",
"pos": [
50,
57
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
125,
141
]
} |
the ability of glucosamine and n-acetylglucosamine to stimulate insulin secretion from perifused rat islets and the suitability of these hexoses to be metabolized in a static incubation was studied under various conditions . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
15,
26
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
31,
50
]
} |
at moderate concentrations , ( 2.75 -- 20 mm ) , the metabolism of n-acetyl [ 1-3h ] glucosamine was similar to that of [ 1-3h ] glucose and secretion rates paralleled the corresponding rates of metabolism with these hexoses . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
129,
136
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
217,
224
]
} |
insulin release caused by 27.5 mm-glucosamine or 27.5 mm-n-acetylglucosamine in the presence of basal ( 2.75 mm ) glucose was accurately predicted based on the summed metabolic rates of these compounds . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
34,
45
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
59,
76
]
} |
the phosphodiesterase inhibitors papaverine , theophylline and 3-isobutyl-1-methylxanthine each stimulated steroid production in a dose-dependent manner . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
46,
58
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
63,
90
]
} |
the induction of ornithine decarboxylase activity in mouse 3t3 fibroblasts or an sv-40 transformed 3t3 cell line by serum was prevented by addition of the naturally occurring polyamines putrescine ( butane-1,4-diamine ) and spermidine . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
175,
185
]
} | {
"id": "C0011957",
"name": "diamine",
"pos": [
210,
217
]
} |
the average number of adp-ribosyl units in the oligomeric chains of the poly ( adp-ribosylated ) proteins was 15 but the range of sizes of ( adp-ribose ) oligomers attached to nuclear proteins was smaller in villus than in crypt cell nuclei . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
97,
105
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
176,
192
]
} |
repeated doses of alpha-difluoromethylornithine , a potent enzyme-activated irreversible inhibitor of ornithine decarboxylase , totally blocked the testosterone-induced increase of putrescine and spermidine in the ventral prostate and of putrescine in the seminal vesicle . | NA | {
"id": "C0037871",
"name": "ventral prostate",
"pos": [
214,
230
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
238,
248
]
} |
the activity of both the microsomal and mitochondrial-matrix hydrolase enzymes was specific for long-chain fatty acyl-coa esters ( c12-c18 ) , with the highest activity for palmitoyl-coa . | NA | {
"id": "C0001374",
"name": "fatty",
"pos": [
107,
112
]
} | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
173,
186
]
} |
high-resolution two-dimensional electrophoresis of the 32p-labelled denatured subunits of each enzyme distinguishes three groups of alkaline phosphatase : ( a ) the liver , bone and kidney isoenzymes , each with a unique isoelectric point in the native form , can be converted into a single form by treatment with neuram... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
95,
101
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
189,
199
]
} |
when an appropriate panel of target cells was used , most of the antibodies in sle sera as detected by this assay appeared to be analogous to a natural thymocytotoxic autoantibody ( nta ) of new zealand mice in its specificity and nature . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
65,
75
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
167,
179
]
} |
these data suggest that e-prostaglandins may degrade articular cartilage directly through dna-dependent rna synthesis of cathepsin-like proteases . | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
121,
130
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
136,
145
]
} |
the therapeutic effectiveness of ( 6r,7r ) -7- ( 2- [ 3,5-dichloro-4-oxo-1 ( 4h ) -pyridyl ] -acetamido ) -3- ( [ ( 5-methyl-1,3,4-t hiadiazol-2-yl ) -thio ] methyl ) -8-oxo-5-thia-1-azabicyclo [ 4,2,0 ] oct-2-ene-2-carboxy lic acid ( cefazedone , refosporen ) , cephazolin , cephacetrile and cephalothin was compared in... | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
276,
288
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
293,
304
]
} |
in particular , the action of n alpha-methyl-histamine has to be considered since its secretory response is approximately 1.5 times greater than that of histamine and its secretion lasted for a longer period of time . | NA | {
"id": "C0025779",
"name": "methyl-histamine",
"pos": [
38,
54
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
153,
162
]
} |
after c-5-alkylsubstitution , both 5-methyl-histamine and n alpha,5-dimethyl-histamine showed secretory action comparable to that of histamine ; | NA | {
"id": "C0025779",
"name": "methyl-histamine",
"pos": [
37,
53
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
133,
142
]
} |
in studies on female wistar rats ( n = 133 ) the nephrotoxicity and kidney concentrations of amikacin , butirosin , gentamicin , kanamycin , bekanamycin , sisomicin , and tobramycin were examined during four weeks therapy and four weeks convalescence . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
93,
101
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
143,
152
]
} |
in studies on female wistar rats ( n = 133 ) the nephrotoxicity and kidney concentrations of amikacin , butirosin , gentamicin , kanamycin , bekanamycin , sisomicin , and tobramycin were examined during four weeks therapy and four weeks convalescence . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
116,
126
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
155,
164
]
} |
the heavier patients necessitated less drug/kg bw . to obtain apnoea than the leaner ones did . | NA | {
"id": "C0005910",
"name": "bw",
"pos": [
47,
49
]
} | {
"id": "C0039870",
"name": "leaner",
"pos": [
78,
84
]
} |
varied effects of dietary sucrose and cholesterol on serum lipids , lipoproteins and apolipoproteins in rhesus monkeys . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
59,
65
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
88,
100
]
} |
in contrast , dietary cholesterol decreased the triglyceride content and increased the cholesterol content of all the lipoprotein classes . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
14,
33
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
87,
98
]
} |
this study was designed to assess hdl levels in children of young men with ihd , compared with children of asymptomatic men . | NA | {
"id": "C0728836",
"name": "children of young",
"pos": [
48,
65
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
95,
103
]
} |
plasma adrenaline and noradrenaline concentrations and dopamine-beta-hydroxylase activity in myocardial infarction with and without cardiogenic shock . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
22,
35
]
} |
plasma adrenaline and noradrenaline concentrations and dopamine-beta-hydroxylase activity in myocardial infarction with and without cardiogenic shock . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
93,
114
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
132,
149
]
} |
in patients with myocardial infarction , with or without cardiogenic shock , plasma noradrenaline and adrenaline concentrations are increased . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
17,
38
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
57,
74
]
} |
in patients with myocardial infarction , with or without cardiogenic shock , plasma noradrenaline and adrenaline concentrations are increased . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
84,
97
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
however , plasma noradrenaline concentrations are considerably higher in patients with cardiogenic shock when compared with those with uncomplicated myocardial infarction . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
87,
104
]
} | {
"id": "C0027051",
"name": "myocardial",
"pos": [
149,
159
]
} |
plasma noradrenaline and adrenaline concentrations showed a sustained increase until death in patients with cardiogenic shock whereas those concentrations were back to normal levels by the end of the third day in patients with uncomplicated myocardial infarction . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} |
plasma noradrenaline and adrenaline concentrations showed a sustained increase until death in patients with cardiogenic shock whereas those concentrations were back to normal levels by the end of the third day in patients with uncomplicated myocardial infarction . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
108,
125
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
241,
262
]
} |
following typical primary anorexia nervosa some subjects enter a state characterized by disordered eating behaviour and emotional instability whilst remaining at or above a normal weight . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
26,
42
]
} | {
"id": "C0013473",
"name": "disordered eating",
"pos": [
88,
105
]
} |
concentrations of urea ( p less than 0.001 ) and albumin ( p less than 0.05 ) were reduced by underfeeding protein , but albumin concentration was affected less by diet than by stage of lactation . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
49,
56
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} |
highly significant inter-site differences were demonstrated for six of the major fatty acids and also for both the total amounts of saturated and unsaturated fatty acids and their ratios . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
81,
92
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
146,
169
]
} |
its amino acid composition is similar to that of tropoelastin , except for higher amounts of acidic amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
93,
110
]
} |
in the rodlike polymer of tmv protein at ph 5.3 , 30 % of the carbons are mobile , which implies rotational motions about carbon -- carbon bonds and/or motions of the protein subunits within the polymer . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
30,
37
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
167,
183
]
} |
mechanism of lipid -- protein interaction in the plasma lipoproteins : relationship of lipid-binding sites to antigenic sites in apolipoprotein a-ii . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
56,
68
]
} |
interactions of lipids and proteins in isolated rat intestinal microvillus membranes were examined by studying the temperature dependence of enzyme activities and of d-glucose transport in relation to the membrane lipid thermotropic transition observed by fluorescence polarization ( 26 +/- 2 degrees c ) and differentia... | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
16,
22
]
} | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
205,
219
]
} |
the mutant protein migrates in sodium dodecyl sulfate-polyacrylamide gel electrophoresis more slowly than the wild type protein , as if its molecular weight were greater by as much as 2000 . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
4,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
complexing heparin or dermatan sulfate with the fluorescent probe acridine orange provides a means of studying electrostatic as well as static and dynamic conformational aspects of these glycosaminoglycans via the thermodynamic and photochemical ( fluorescence fading ) properties of these complexes . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
11,
18
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
187,
205
]
} |
the raman spectra of the three protein species do , however , exhibit a number of bands not observed in the rr spectra of other hemoproteins upon exicitation in their visible absorption bands . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
31,
38
]
} | {
"id": "C0018974",
"name": "hemoproteins",
"pos": [
128,
140
]
} |
factor v and factor va binding to single bilayer phospholipid vesicles was investigated by light-scattering intensity measurements . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
0,
8
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
13,
22
]
} |
the average factor v and factor va values for the dissociation constants and lipid to protein ratio at saturation ( moles/mole ) were kd = 7.2 x 10 ( -8 ) m and n = 270 for factor v and kd = 4.4 x 10 ( -7 ) m and n = 76 for factor va . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
12,
20
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
224,
233
]
} |
in contrast to prothrombin and factor x , factor v and factor va demonstrated ca2+-independent lipid binding . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
42,
50
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
55,
64
]
} |
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