text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in addition , the number of factor v and factor va molecules bound per vesicle was found to be dependent both on the phosphatidylserine content of the vesicle and the ionic strength of the buffer . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
28,
36
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
41,
50
]
} |
dna polymerases beta and gamma , phage t4 and t7 dna polymerases , and escherichia coli dna polymerase i were 100 -- 250 times more sensitive . | NA | {
"id": "C0525039",
"name": "dna polymerases beta",
"pos": [
0,
20
]
} | {
"id": "C0012892",
"name": "dna polymerases",
"pos": [
49,
64
]
} |
in vivo inhibition of mitochondrial protein synthesis by the chloramphenicol analogue thiamphenicol leads to the formation of an oligomycin-insensitive membrane-bound atpase complex in mitochondria of regenerating rat liver . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
61,
76
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
86,
99
]
} |
sodium dodecyl sulphate gel electrophoresis of the membrane proteins revealed 17 and 19 protein bands , respectively , for glucose and hexadecane grown cells . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
51,
68
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} |
the fatty acid composition of mitochondrial membranes from sheep and rats was altered by feeding these animals diets which were rich in unsaturated fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015690",
"name": "unsaturated fatty",
"pos": [
136,
153
]
} |
the results show that membrane lipid fluidity has a direct influence on the conformation of the active site of some membrane-associated enzymes , with the result that such enzymes display a higher ea when the membrane lipids are comparatively more fluid . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
31,
36
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
209,
224
]
} |
sulfate and oxalate transfer , which proceed via the inorganic anion-exchange system , are essentially unaffected by cleavage of phosphatidylcholine and less sensitive to sphingomyelin cleavage than the two other processes . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
0,
7
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
63,
68
]
} |
this interaction is important as it relates to the transfer of the apolipoproteins c and phospholipids from very low density lipoproteins to other plasma lipoproteins . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
108,
137
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
154,
166
]
} |
a comparison is made of the interaction of arginine side chain with nucleic acid bases , phosphate and carboxylate anions . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
89,
98
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
115,
121
]
} |
neither the brain enzyme form i5.9 nor the major heart isoenzyme are inhibited by antiserum to the muscle enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
18,
24
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
55,
64
]
} |
stopped-flow kinetic studies of the anaerobic reduction of rhus vernicifera laccase ( monophenol , dihydroxyphenylalanine : oxygen oxidoreductase , ec 1.14.18.1 ) type 1 copper by 25 mono- and disubstituted hydroquinones ( h2q-x ) have been performed at 25 degrees c and ph 7.0 in 0.5 m phosphate . | NA | {
"id": "C0064566",
"name": "laccase",
"pos": [
76,
83
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
148,
152
]
} |
application of the procedure to data obtained for the reaction catalyzed by aspartate aminotransferase ( l-aspartate:2-oxoglutarate aminotransferase , ec 2.6.1.1 ) , showed that the resulting values for the kinetic parameters agreed well with those obtained by conventional progress curve analysis ( duggleby , r.g . and... | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
76,
102
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
132,
148
]
} |
the common identity of human acidic beta-d-glucosidase ( beta-d-glucoside glucohydrolase , ec 3.2.1.21 ) and beta-d-xylosidase ( 1,4-beta-d-xylan xylohydrolase , ec 3.2.1.37 ) as one enzyme and that of acidic beta-d-galactosidase ( beta-d-galactoside galactohydrolase , ec 3.2.1.23 ) , beta-d-fucosidase ( no allotted ec... | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
586,
590
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
623,
634
]
} |
thus it has been shown that the aromatic amino acid aminotransferase ( aromatic-amino-acid : 2-oxoglutarate amino-transferase , ec 2.6.1.57 ) reacts specifically with chorismate mutaseprephenate dehydrogenase ( chorismate pyruvate mutase , ec 5.4.99.5 and prephenate : nad+ oxidoreductase ( decarboxylating ) , ec 1.3.1.... | NA | {
"id": "C0008514",
"name": "chorismate",
"pos": [
167,
177
]
} | {
"id": "C0524938",
"name": "mutase",
"pos": [
372,
378
]
} |
thus it has been shown that the aromatic amino acid aminotransferase ( aromatic-amino-acid : 2-oxoglutarate amino-transferase , ec 2.6.1.57 ) reacts specifically with chorismate mutaseprephenate dehydrogenase ( chorismate pyruvate mutase , ec 5.4.99.5 and prephenate : nad+ oxidoreductase ( decarboxylating ) , ec 1.3.1.... | NA | {
"id": "C0008514",
"name": "chorismate",
"pos": [
167,
177
]
} | {
"id": "C0033068",
"name": "prephenate",
"pos": [
403,
413
]
} |
antibodies against homogeneous rabbit liver arylsulfatase a ( aryl-sulfatase sulfohydrolase , ec 3.1.6.1 ) were produced in a goat and the effects of these antibodies on the kinetic parameters of the enzyme have been studied . | NA | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
44,
59
]
} | {
"id": "C0003940",
"name": "aryl-sulfatase",
"pos": [
62,
76
]
} |
the enzyme-antibody complex still showed the characteristic arylsulfatase a anomalous kinetics at ph 5.5 , but the inactivation was significantly slower than for the native enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
173,
179
]
} |
delta-aminolevulinic acid dehydratase ( 5-aminolevulinic acid hydro-lyase ( adding 5-aminolevulinic acid and cyclizing ) , ec 4.2.1.24 purified from bovine liver in the presence of both sh-reducing reagent and zinc during the purification contained one zinc atom and eight sh groups/subunit . | NA | {
"id": "C0002564",
"name": "delta-aminolevulinic acid dehydratase",
"pos": [
0,
37
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
62,
73
]
} |
however , the enzymatic activity was completely lost , with a concomitant loss of bound zinc , upon oxidation of the sh groups to a disulfide bond , modification of sh groups with chemical reagents , or mercaptide formation by heavy metals . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
88,
92
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
227,
239
]
} |
the immobilized enzyme showed very little change in its sensitivity to heat and to inhibition by semicarbazide as compared with the soluble enzyme , but had enhanced stability at 0 degrees c . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
140,
146
]
} |
two isoenzymes of the enzyme , types i and ii , were distinguished by the following procedures : trypsin treatment , heat treatment , cm-cellulose chromatography , antibody titration , and sucrose density gradient centrifugation of the light mitochondrial fraction . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
4,
14
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
22,
28
]
} |
both isozymes were induced by the administration to the rats of di- ( 2-ethylhexyl ) phthalate , which enhances the peroxisomal beta-oxidation activity , but the extent of the induction of type ii enzyme was much higher than that of type i enzyme . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
5,
13
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
240,
246
]
} |
the resistant strain maintained its fatty acid composition and a normal [ 32p ] phosphate distribution among phospholipids while the wild type shifted to a higher content in unsaturated fatty acids and to a high relative cardiolipin labelling . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
36,
41
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
174,
197
]
} |
the blue enzyme , representing a complex of yellow enzyme with 13-l-hydroperoxylinoleic acid exhibits a negative dichroic band at 580 nm and positive bands at 410 and 391 nm . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
9,
15
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
33,
40
]
} |
prostaglandin synthesis in human diploid fibroblasts was studied by incubating [ 14c ] -arachidonic acid with cell homogenates . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
110,
114
]
} |
in stimulated tissue , [ 1-14c ] acetate-labeled fatty acids were incorporated into phosphatidylinositols , 1,2-diacylglycerols , and phosphatidic acids in preference to phosphatidylcholines , phosphatidylethanolamines , triacylglycerols , monoacylglycerols , and free fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
49,
60
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
264,
280
]
} |
it was concluded that human fibroblast cells in culture have at least two mechanisms for triacylglycerol uptake from vldl : ( 1 ) uptake from intact lipoprotein either by surface transfer of lipoprotein lipid or internalization of the entire lipoprotein particle , and ( 2 ) re-esterification of lower glyceride and fatt... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
149,
160
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
374,
378
]
} |
subcellular localization of bisphosphatidic acid , semilysobisphosphatidic acid and phosphatidyl- ( n-acyl ) ethanolamine was studied in normal and degenerating fibroblasts ( bhk21 cells ) by differential centrifugation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
161,
172
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
181,
186
]
} |
its amino acid composition differed from bovine beta-casein especia-ly in respect to serine , alanine and leucine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
94,
101
]
} |
the soluble hydrogenase ( hydrogen : nad+ oxidoreductase ( ec 1.12.1.2 ) from alcaligenes eutrophus has been purified to homogeneity by an improved procedure , which includes preparative electrophoresis as final step . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
12,
23
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
42,
56
]
} |
the spectrum approximated the average between the spectra induced by the two proteins when the ratio of bovine alpha-fetoprotein to bovine albumin was 6.3 : 1 , and of the human proteins 21 : 1 , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
77,
85
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
139,
146
]
} |
catecholamines competed for [ 3h ] dihydroalprenolol binding sites with a potency of isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
112,
123
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
137,
151
]
} |
known beta-adrenergic antagonists , propranolol and alprenolol , stereospecifically inhibited the [ 3h ] dihydroalprenolol binding and the isoproterenol-stimulated adenylate cyclase . | NA | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
52,
62
]
} | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
105,
122
]
} |
the membrane glycoprotein enzyme , alkaline phosphatase was induced in cultured human fibroblasts by dibutyryl cyclic amp , sodium butyrate , the serum glycoprotein fetuin , the tamm-horsfall urinary glycoprotein , and by a number of inhibitors of dna synthesis . | NA | {
"id": "C0025248",
"name": "membrane glycoprotein",
"pos": [
4,
25
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
200,
212
]
} |
the effect of several amino acids ( l-glutamate , l-phenylalanine , l-leucine , glycine , l-tryptophan , l-histidine , l-valine ) on p-aminohippurate accumulation was evaluated in rat , mouse and rabbit kidneys . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
80,
87
]
} |
the early 2 -- 3-fold increase in cyclic amp accumulation elicited by adenosine and 2-chloroadenosine , an adenosine deaminase-resistant analogue , could not be correlated to similar effects on the adenylate cyclase activity of disrupted cell preparations , but rather to the competitive inhibition of the low km ( 0.17 ... | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
70,
79
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
84,
101
]
} |
the concentrations of total lipid and unesterified fatty acids within the fetal plasma were considerably lower than in the maternal plasma thereby providing an adverse concentration gradient for the passage of fatty acids between fetus and mother . | NA | {
"id": "C0015688",
"name": "unesterified fatty acids",
"pos": [
38,
62
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
210,
221
]
} |
the changes of insulin , blood sugars , lactate and free fatty acid levels were studied in 12 newborns of diabetic mothers and in 21 newborns of healthy mothers in the course of intravenous infusions of glucose and galactose at a dose of 0.5 g.kg-1.h-1 . | NA | {
"id": "C0005802",
"name": "blood sugars",
"pos": [
25,
37
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
203,
210
]
} |
methane-oxygen enhanced negative ion mass spectra of 15 chlorinated diphenyl ethers contained some combination of [ m- ] -. , [ m-1 ] - , [ m-19 ] - , [ m-36 ] - , [ m-55 ] - , and [ m+35 ] - anions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
33,
36
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
192,
198
]
} |
a quantitative method is reported for the determination of n-hexane , 2-hexanone and 2,5-hexanedione in biological tissues by stable isotope dilution using gas chromatography mass spectrometry . n- [ 2h14 ] hexane , 2- [ 2h5 ] hexanone and 2,5- [ 2h10 ] hexanedione are used as the isotopic diluents . | NA | {
"id": "C0025708",
"name": "2-hexanone",
"pos": [
70,
80
]
} | {
"id": "C0019464",
"name": "hexanone",
"pos": [
227,
235
]
} |
data are presented to show that the unusual ketone , 3-pentanone , which has been observed previously in the urine of patients with propionic acidemia , is produced as a result of the decarboxylation of 3-keto-2-methylvaleric acid . | NA | {
"id": "C0022634",
"name": "ketone",
"pos": [
44,
50
]
} | {
"id": "C0030871",
"name": "pentanone",
"pos": [
55,
64
]
} |
the enzyme thermistor measures the heat produced by the action of an immobilized enzyme on a substrate present in the sample . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0014444",
"name": "immobilized",
"pos": [
69,
80
]
} |
after a brief presentation of the method , 246 cases of malignant lymphoma are analysed : 95 of hodgkins disease , 103 of non-hodgkins malignant lymphoma of the nodes and 48 cases of extranodal non-hodgkins malignant lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
56,
74
]
} | {
"id": "C0019829",
"name": "hodgkins disease",
"pos": [
96,
112
]
} |
after a brief presentation of the method , 246 cases of malignant lymphoma are analysed : 95 of hodgkins disease , 103 of non-hodgkins malignant lymphoma of the nodes and 48 cases of extranodal non-hodgkins malignant lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
56,
74
]
} | {
"id": "C0024305",
"name": "non-hodgkins malignant lymphoma",
"pos": [
194,
225
]
} |
the dipeptide , carnosine , its synthetic enzyme , carnosine synthetase , and its degradative enzyme , carnosinase , appear to be localized in the cytosol of mouse olfactory bulb and epithelium . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
4,
13
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
51,
60
]
} |
( 2 ) thy-1 was present on fibroblasts and some neurons but not on the majority of leptomeningeal cells or on oligodendrocytes or astrocytes in short-term cultures ( however , it was expressed on some astrocytes in longer term cultures ) ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
98,
103
]
} |
( 3 ) the 'large external transformation sensitive ' ( lets ) protein could be detected on fibroblasts and leptomeningeal cells but not on neurons or glial cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
91,
102
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
156,
161
]
} |
the highest dopamine concentration ( 2,4 ng/mg protein ) was measured in the rostral pyriform cortex but other mesocortical ( cingulate , frontal , insular and entorhinal ) dopaminergic areas also contained relatively high amounts . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
12,
20
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
173,
185
]
} |
treatment with cysteic acid 30 min prior to ethanol , 2.5 g/kg , ip , was found to decrease whole blood ethanol concentration as compared to the respective controls without a concomitant changes in brain ethanol levels . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
44,
51
]
} | {
"id": "C0684262",
"name": "blood ethanol concentration",
"pos": [
98,
125
]
} |
the analysis for cholesterol esters showed that about 50 % of ( 4-14c ) cholesterol taken up by the brain tissue had undergone esterification . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
17,
35
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
72,
83
]
} |
the data indicate that these cell peaks may be comprised of osteoclasts and/or preosteoclasts , osteoblasts and/or preosteoblasts , and fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
29,
33
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
136,
147
]
} |
in rats up to 2 weeks old , only one glycosaminoglycan could be detected as heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
37,
54
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
76,
91
]
} |
nevertheless , the influence of magnesium and calcium ions on the atpase activity of alkaline phosphatase means that precautions must be taken when assaying for ca2+-atpase in the presence of alkaline phosphatase . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
66,
72
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
161,
164
]
} |
the furanocoumarin o-methyltransferases , which transfer a methyl group from s-adenosyl-l-methionine ( sam ) to the 5- or 8-hydroxyls of linear furanocoumarins , were not retarded by 5- ( 3-carboxypropanamido ) -xanthotoxin ( cpax ) immobilized to ah-sepharose 4b , but addition of sam to the irrigant buffer led to comp... | NA | {
"id": "C0016859",
"name": "furanocoumarins",
"pos": [
144,
159
]
} | {
"id": "C0025684",
"name": "xanthotoxin",
"pos": [
212,
223
]
} |
the results show that the proline residue in position 7 of [ sar1 , ile8 ] -angiotensin ii may be replaced by other secondary amino acids without disrupting interactions at angiotensin ii receptors . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
26,
33
]
} | {
"id": "C0020931",
"name": "secondary amino acids",
"pos": [
116,
137
]
} |
significant susceptibility to photically induced seizures has in the past been observed only in senegales baboons ( papio papio ) and epileptic humans . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
49,
57
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
134,
143
]
} |
the results showed no difference in uptake kinetics of either dicarboxylic amino acids between friedreich 's ataxia and normal cells , but reduced uptake velocities in dicarboxylic aminoaciduria fibroblasts . | NA | {
"id": "C0007634",
"name": "normal cells",
"pos": [
120,
132
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
195,
206
]
} |
fatty acid profile of major lipid classes in plasma lipoproteins of patients with friedreich 's ataxia-demonstration of a low linoleic acid content most evident in the cholesterol-ester fraction . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
28,
33
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
52,
64
]
} |
the hdl phospholipid ( pl ) fraction also showed a reduction in the proportion of 18:2 with a concomitant increase in stearic ( 18:0 ) and oleic acid ( 18:1 ) while the hdl triglyceride ( tg ) fraction showed only an increase in palmitoleic ( 16:1 ) and oleic acids . | NA | {
"id": "C0028928",
"name": "oleic acid",
"pos": [
139,
149
]
} | {
"id": "C0028929",
"name": "oleic acids",
"pos": [
254,
265
]
} |
feeding of soya lecithin rich in 18:2 failed to increase significantly the 18:2 content of hdl-ce and hdl-pl but lowered the percentage of 16:1 and 18:1 in all 3 lipid classes of hdl . | NA | {
"id": "C0062709",
"name": "2",
"pos": [
36,
37
]
} | {
"id": "C0023821",
"name": "hdl",
"pos": [
179,
182
]
} |
they postulate a defective incorporation of linoleic acid to surface phosphatidylcholine of chylomicrons and consequent relative and absolute decreases in lipoprotein protein components because of overpacking with defective cholesteryl esters . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
92,
104
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
155,
166
]
} |
it would appear that pyrantel pamoate administered at 13.2 mg pyrantel base/kg is an effective therapeutic dose for tapeworms in horses . | NA | {
"id": "C0034237",
"name": "pyrantel pamoate",
"pos": [
21,
37
]
} | {
"id": "C0034235",
"name": "pyrantel",
"pos": [
62,
70
]
} |
pathophysiology of `` '' cold spot '' '' and `` '' hot spot '' '' myocardial imaging agents used to detect ischemia or infarction . | NA | {
"id": "C0022116",
"name": "ect isch",
"pos": [
103,
111
]
} | {
"id": "C0021308",
"name": "or infarc",
"pos": [
116,
125
]
} |
this chapter is a primer on the physics of radionuclide detection , flow physiology , and methods of in vivo evaluation of myocardial metabolism and intercavitary flow by noninvasive methods of intravenous isotope injection . | NA | {
"id": "C0034595",
"name": "radionuclide",
"pos": [
43,
55
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
206,
213
]
} |
the adequacy of oxygen-supply to the left ventricular myocardium was compared in anaesthetised dogs following : a ) isovolaemic haemodilution with dextran 70 ( to haematocrit = 20 +/- 2 % ) , b ) the acute induction of methaemoglobinaemia ( to methaemoglobin-concentration = 53 +/- 7 % ) , bu subjecting them to an excha... | NA | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
147,
157
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
471,
478
]
} |
an electron microscopic study of lipid absorption in the pyloric caeca of rainbow trout ( salmo gairdnerii ) fed wax ester -- rich zooplankton . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
33,
38
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
113,
116
]
} |
and fourth , the fraction of total nonribosomal nuclear rna complementary to the nine cloned dna segments is in most cases 10 fold less than the fraction of cytoplasmic mrna complementary to the same cloned dna segments , suggesting the synthesis of many hnrna molecules that are qualitatively different from those which... | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
48,
59
]
} | {
"id": "C0035695",
"name": "hnrna",
"pos": [
255,
260
]
} |
chick embryo ( ce ) fibroblasts and normal rat kidney ( nrk ) cells transformed by temperature-sensitive ( ts ) mutants of avian sarcoma virus ( ny68 , la23 , la24 , la25 , la29 , la31 , gi201 , gi202 , gi251 , gi253 induce tumors on the chorioallantoic membrane ( cam ) of chick eggs at temperatures that correspond to ... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
36,
42
]
} |
these cells have the potential in culture to differentiate into erythroid cells , beating heart muscle tissue , chondrocytes and epithelial cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
112,
124
]
} |
althought the fibronectin of control chondrocytes was of a slightly lower apparent molecular weight than the fibronectin synthesized by the treated cells , it bound as effectively to the cell layer of both normal and treated cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
37,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
225,
230
]
} |
thus in chondrocytes , vitamin a appears to regulate the cellular accumulation of fibronectin by increasing the ability of the cell layer to bind fibronectin rather than by altering its synthesis or its adhesivity for the cell layer . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
8,
20
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
222,
226
]
} |
using cloned echinus histone dna , heterologous 5s dna and ribosomal dna probes , we have found that each of these gene families belongs to the unmethylated dna compartment in all the tissues examined . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
59,
72
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
157,
160
]
} |
the 3.0 and 2.8 kb transcripts are apparently encoded by.a 2.6 kb segment of dna and one or more much smaller noncontiguous dna segments , one of which is approximately 170 nucleotides long . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
after the age of one , 1 non-neoplastic cyst and 12 tumors : 8 germ-cell tumors , 3 tumors of specialized gonadal stroma , and one epithelial tumor . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
40,
44
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
84,
90
]
} |
building on the single-beat analysis , a contextual diagnostic algorithm then recognizes and reports on-line the following arrhythmias : couplets , bigeminy , trigeminy , ventricular tachycardia , supraventricular tachycardia , atrial flutter , atrial fibrillation , ventricular tachycardia with retrograde conduction to... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
123,
134
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
228,
242
]
} |
building on the single-beat analysis , a contextual diagnostic algorithm then recognizes and reports on-line the following arrhythmias : couplets , bigeminy , trigeminy , ventricular tachycardia , supraventricular tachycardia , atrial flutter , atrial fibrillation , ventricular tachycardia with retrograde conduction to... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
123,
134
]
} | {
"id": "C0004238",
"name": "atrial",
"pos": [
245,
251
]
} |
patients had a variety of problems associated with their arrhythmia , including mitral valve prolapse , cardiomyopathy , myocarditis , prolonged qt syndrome and hypokalemia . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
104,
118
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
121,
132
]
} |
cultured skin fibroblast and primary amniotic fluid cell alpha-l-fucosidase had a double optimum of ph 5.0 and 6.0 . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
52,
56
]
} |
incubation of 4-methylumbelliferyl alpha-l-iduronide with whole cell homogenates prepared from cultured skin fibroblasts and amniotic cells , and peripheral blood leukocytes gave 4-methylumbelliferone which was easily measured fluorometrically . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
134,
139
]
} |
a method is presented whereby cholesterol , cholesterol ester , triacylglycerol , non-esterified fatty acid and polar lipid in plasma may be simultaneously quantitated . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
44,
61
]
} |
significant amounts of the diamine putrescine and the polyamines spermidine and spermine could be detected in human third-trimester amniotic fluid only after acid hydrolysis . | NA | {
"id": "C0011957",
"name": "diamine",
"pos": [
27,
34
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
54,
64
]
} |
urinary excretion of 3-methoxy-4-hydroxyphenylglycol ( mhpg ) , noradrenaline , adrenaline and vanillylmandelic acid ( vma ) was studied in 30 patients with acute myocardial infarction . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} |
determination of noradrenaline and adrenaline in plasma by a radioenzymatic assay using high pressure liquid chromatography for the separation of the radiochemical products . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
17,
30
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
35,
45
]
} |
noradrenaline and adrenaline are converted to their o-methylated analogues , normethanephrine and metanephrine , by the enzyme catechol o-methyltransferase in the presence of tritiated s-adenosyl-l-methionine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} |
noradrenaline and adrenaline are converted to their o-methylated analogues , normethanephrine and metanephrine , by the enzyme catechol o-methyltransferase in the presence of tritiated s-adenosyl-l-methionine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
3,
13
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
98,
110
]
} |
the detection limit for noradrenaline is 32 ng/l plasma and for adrenaline 16 ng/l plasma . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
24,
37
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
intra- and interassay variables are respectively 6.2 and 10 % for noradrenaline and 5.3 and 8.8 % for adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
66,
79
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
the mean supine levels of noradrenaline and adrenaline in normal subjects are 355 and 61 ng/l plasma , respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
26,
39
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
44,
54
]
} |
turbidimetric determination of the cholestasis characterizing lipoprotein-x is based on the separation from the serum investigated of interfering lipoproteins by precipitation with the appropriate concentration of heparin and zinc acetate followed by centrifugation . | NA | {
"id": "C0023819",
"name": "lipoprotein-x",
"pos": [
62,
75
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
146,
158
]
} |
in order to investigate the degree of similarity between renal transplant and non-renal combined hyperlipidemic and hypertriglyceridemic patients , serum and lipoprotein lipid compositions were compared in transplant and non-renal combined hyperlipidemic and in transplant and non-renal hypertriglyceridemic patients , a... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
158,
169
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
245,
250
]
} |
these findings suggest that some apolipoprotein b in vary low density lipoprotein is not `` '' recognised '' '' by anti-apolipoprotein b antibodies , hence radioimmunoassay results are lower than those obtained with the tetramethylurea extraction method . | NA | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
33,
49
]
} | {
"id": "C0003591",
"name": "i-apolipoprote",
"pos": [
118,
132
]
} |
in patients with hepatic porphyrias ( acute intermittent porphyria and porphyria cutanea tarda ) the activity of porphobilinogen oxygenase was very low . | NA | {
"id": "C0162533",
"name": "hepatic porphyrias",
"pos": [
17,
35
]
} | {
"id": "C0162565",
"name": "acute intermittent porphyria",
"pos": [
38,
66
]
} |
in patients with hepatic porphyrias ( acute intermittent porphyria and porphyria cutanea tarda ) the activity of porphobilinogen oxygenase was very low . | NA | {
"id": "C0162533",
"name": "hepatic porphyrias",
"pos": [
17,
35
]
} | {
"id": "C0162566",
"name": "porphyria cutanea",
"pos": [
71,
88
]
} |
the concentrations of lipids and lipoproteins measured in capillary blood serum taken from young adults were significantly lower than in venous blood , although they correlated satisfactorily . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
22,
28
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
33,
45
]
} |
adrenoleukodystrophy is an unusual disorder in which progressive diffuse demyelination of the cerebrum is associated with adrenal insufficiency , and which is transmitted as a sex-linked recessive trait . | NA | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
0,
20
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
122,
143
]
} |
one brother died at age 7 with schilder 's disease , while another brother suffered adrenal insufficiency , progressive mental and neurological deterioration and death at age 38 with post-mortem evidence of adrenoleukodystrophy . | NA | {
"id": "C0001623",
"name": "adrenal",
"pos": [
84,
91
]
} | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
207,
227
]
} |
a total of 103 patients were found to have an abnormal chromosome complement , of whom 91 had down 's syndrome ( including six with translocations ) , six had some other autosomal abnormality , and six had an abnormality of the sex chromosome complement , including two with an xxyy complement . | NA | {
"id": "C0040715",
"name": "translocations",
"pos": [
132,
146
]
} | {
"id": "C0008626",
"name": "abnormality of",
"pos": [
209,
223
]
} |
relative importance of c3b inactivator and beta 1h globulin in the modulation of the properdin amplification loop in systemic lupus erythematosus . | NA | {
"id": "C0005157",
"name": "beta",
"pos": [
43,
47
]
} | {
"id": "C0033452",
"name": "properdin",
"pos": [
85,
94
]
} |
serum concentrations of c4 , c3 , factor b ( b ) , properdin ( p ) , c3b inactivator ( c3bina ) and beta 1h globulin have been measured by radial immunodiffusion in sixty-two samples from thirteen patients with systemic lupus erythematosus ( sle ) . | NA | {
"id": "C0033452",
"name": "properdin",
"pos": [
51,
60
]
} | {
"id": "C0005157",
"name": "beta",
"pos": [
100,
104
]
} |
that the cytoplasmic structures are intermediate filaments was suggested by their rearrangement into coils of perinuclear filaments in colchicine- or vinblastine-treated fibroblasts , but not in cytochalasin b-treated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
170,
181
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
218,
223
]
} |
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