text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
heparan sulfate is excreted with a circadian rhythm , as is glycosaminoglycan assayed by cetyl pyridinium turbidity . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
0,
15
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
60,
77
]
} |
at each testing , a 100-gm oral glucose load was administered and blood glucose and plasma insulin values were measured over a three-hour period . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
32,
39
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
66,
79
]
} |
in two patients the original arrhythmia was converted to atrial fibrillation during stimulation , but in one it disappeared with pacing at 110/min , and in the other , reversion to sinus rhythm occurred spontaneously 4 hours later . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
29,
39
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
57,
76
]
} |
primate repetitive dnas : evidence for new satellite dnas and similarities in non-satellite repetitive dna sequence properties . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
19,
23
]
} | {
"id": "C0012934",
"name": "satellite dnas",
"pos": [
43,
57
]
} |
an alternate route of metabolism of the gsh conjugate involves beta-elimination of halide ion to form an olefin . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
22,
32
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
68,
79
]
} |
patients with erysipelas , impetiginized dermatoses and pyodermia were treated during an average period of 9 days mainly with a dosage of 2x1 g i.v. , in some cases with 2x2 g i.v . daily . | NA | {
"id": "C0037274",
"name": "dermatoses",
"pos": [
41,
51
]
} | {
"id": "C0034212",
"name": "pyodermia",
"pos": [
56,
65
]
} |
the development of missouri 's new lead belt within the past decase has provided an excellent opportunity to study the dissemination and effects of heavy metals in a deciduous forest ecosystem . | NA | {
"id": "C0023175",
"name": "lead",
"pos": [
35,
39
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
148,
160
]
} |
sintering and blast furnace operations tend to produce significant quantities of small particulates highly enriched in cadmium and other heavy metals . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
119,
126
]
} | {
"id": "C0347988",
"name": "heavy",
"pos": [
137,
142
]
} |
cadmium and other heavy metals have been found to accumulate in the forest litter and partially decomposed litter along stream beds . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
0,
7
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
18,
30
]
} |
this protein has a molecular weight of 100000 and is identical to the virus coded '100k ' protein found previously . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0042736",
"name": "virus",
"pos": [
70,
75
]
} |
dormant and developing embryos of artemia salina contain equivalent amounts of eif-2 , the eukaryotic initiation factor which forms a ternary complex with gtp and met-trnaf . | NA | {
"id": "C0013729",
"name": "eif-2",
"pos": [
79,
84
]
} | {
"id": "C1136317",
"name": "eukaryotic initiation factor",
"pos": [
91,
119
]
} |
the enzyme was stabilized against thermal inactivation at 80 degrees c by gssg and less markedly by nadp+ and gsh , but not by nadph or fad . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
74,
78
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
110,
113
]
} |
and thirdly , the order of potencies for agonists to displace bound tracer ( isoproterenol congruent to protokylol greater than norepinephrine congruent to epinephrine ) similar to the one found for adenylate cyclase activation , and typical for beta 1-adrenergic receptors . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
128,
142
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
156,
167
]
} |
the procollagen peptide consists of three segments , an n-terminal globular domain which contains all the cysteine residues and most of the hydrophobic residues present in the entire peptide , a triple helical part with a relatively high content of proline and hydroxyproline , and a short nonhelical region which forms ... | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
261,
275
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
410,
417
]
} |
the procollagen peptide consists of three segments , an n-terminal globular domain which contains all the cysteine residues and most of the hydrophobic residues present in the entire peptide , a triple helical part with a relatively high content of proline and hydroxyproline , and a short nonhelical region which forms ... | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
4,
15
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
528,
536
]
} |
four sialoglycoproteins were identified by their reduced electrophoretic migration after neuraminidase treatment , and six proteins interacted with various lectins , indicating them to be glycosylated . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
156,
163
]
} |
the capacity of human peripheral blood lymphocytes to bind antigen-igg or antigen-igm-antibody complexes was investigated using a rosette technique with ox erythrocytes ( e ) coated with rabbit igg ( ag ) or igm ( am ) antibodies . | NA | {
"id": "C0003313",
"name": "antigen",
"pos": [
59,
66
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
219,
229
]
} |
cyclic gmp and dibutyryl cyclic gmp produced only slight negative chronotropic and inotropic effects but not consistently even at larger doses . | NA | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
0,
10
]
} | {
"id": "C0012055",
"name": "dibutyryl cyclic gmp",
"pos": [
15,
35
]
} |
the effect of potassium on the binding of digoxin or digoxigenin to isolated na+ , k+-atpase was compared with that of potassium on the positive inotropic action of the agents in guinea-pig hearts . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
42,
49
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
53,
64
]
} |
in contrast , potassium reduced the rate of development and also the rate of loss of the positive inotropic action of digoxin observed with left atrial and langendorff preparations , respectively , to a greater extent than those of digoxigenin . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
118,
125
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
232,
243
]
} |
the loss of the positive inotropic effect was more rapid with digoxigenin than with digoxin at each kcl concentration . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
62,
73
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
84,
91
]
} |
the effect of intracutaneous adrenaline and noradrenaline ( 5 x 10 ( -12 ) and 5 x 10 ( -11 ) mol ) was examined on the oedema ( evans blue dye leakage ) response of rats to several inflammatory agents . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} |
adrenaline was more effective than noradrenaline in reducing oedema produced by 5-hydroxytryptamine ( 5ht ) and histamine and by agents which release these amines ( compound 48/80 , dextran and antigen challenge with egg albumin in sensitized rats ) , but noradrenaline was more potent against bradykinin-induced oedema ... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
256,
269
]
} |
a fluorescence-activated cell sorter has been used to sort out enriched populations of murine hemopoietic stem cells from mouse bone marrow , based on fluorescence of cells labeled with various antisera . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
94,
116
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
experimental study of absorption , distribution , metabolism and excretion of salicylic acid and salicylate upon ageing showed that the sodium salicylate absorption rate is considerably decreased in old rats and rabbits . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
50,
60
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
65,
74
]
} |
experimental study of absorption , distribution , metabolism and excretion of salicylic acid and salicylate upon ageing showed that the sodium salicylate absorption rate is considerably decreased in old rats and rabbits . | NA | {
"id": "C0036079",
"name": "salicylic acid",
"pos": [
78,
92
]
} | {
"id": "C0037549",
"name": "sodium salicylate",
"pos": [
136,
153
]
} |
a role for enkephalin in the mediation of behavioral reinforcement is supported by several lines of evidence : i ) central injections of enkephalin serve as reinforcement for self-administration behavior , ii ) electrical stimulation of many enkephalin-rich regions serves as reinforcement for self-stimulation behavior ... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
11,
21
]
} | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
489,
510
]
} |
the residual rcbf and the duration of ischemia determine the appearance of infarction in waking macaca irus monkeys . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
38,
46
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
75,
85
]
} |
the formation of these metabolites is maximal in vitamin a-deficient hamsters that have been pretreated with retinoic acid and in vitamin a-normal animals . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
109,
122
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
130,
139
]
} |
dynamics of noradrenalin , adrenalin , dipeptide homocarnosine , gaba , hystidine , mao activity ( with noradrenalin as substrate ) , and homocarnosincarnosinsynthetase in the rat brain under hyperbaroxygenation , was studied . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
15,
24
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
104,
116
]
} |
the ultrastructive of aspergillus fumigatus , aspergillus flavus and aspergillus niger was studied when treated in vitro with 0.001 , 0.01 and 0.1 % econazole nitrate and econazole base . | NA | {
"id": "C0546862",
"name": "econazole",
"pos": [
149,
158
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
171,
180
]
} |
nevertheless , it should be kept in mind that mycoses , e.g. , cryptococcosis , coccidioidomycosis , and histoplasmosis , in compromised hosts are not necessarily the result of recent exposure but may be the result of the reactivation of latent or inactive forms . | NA | {
"id": "C0026946",
"name": "mycoses",
"pos": [
46,
53
]
} | {
"id": "C0009186",
"name": "coccidioidomycosis",
"pos": [
80,
98
]
} |
nevertheless , it should be kept in mind that mycoses , e.g. , cryptococcosis , coccidioidomycosis , and histoplasmosis , in compromised hosts are not necessarily the result of recent exposure but may be the result of the reactivation of latent or inactive forms . | NA | {
"id": "C0026946",
"name": "mycoses",
"pos": [
46,
53
]
} | {
"id": "C0019655",
"name": "histoplasmosis",
"pos": [
105,
119
]
} |
direct addition of cyclic amp or dibutyryl cyclic amp to isolated renal tubules caused increased efflux of calcium , while addition of 5'-amp did not . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
19,
29
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
33,
53
]
} |
various water-insoluble cannabinoids as well as sp-111a , the water-soluble derivative of delta 9-tetrahydrocannabinol ( delta 9-thc ) , reduced hcg and dibutyryl-camp stimulated testosterone production by rat testicular leydig cell preparations . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
24,
36
]
} | {
"id": "C0039663",
"name": "delta 9-tetrahydrocannabinol",
"pos": [
90,
118
]
} |
dose-related inhibitions were apparent with other cannabinoids and their order of potency in inhibiting stimulated steroidogenesis by the interstitial cells in vitro was found to be : 8-beta-oh-delta 9-thc greater than or equal to 11-oh-delta 9-thc greater than cbn = cbd = cbg greater than or equal delta 9-thc = delta ... | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
50,
62
]
} | {
"id": "C0006865",
"name": "cbn",
"pos": [
262,
265
]
} |
dose-related inhibitions were apparent with other cannabinoids and their order of potency in inhibiting stimulated steroidogenesis by the interstitial cells in vitro was found to be : 8-beta-oh-delta 9-thc greater than or equal to 11-oh-delta 9-thc greater than cbn = cbd = cbg greater than or equal delta 9-thc = delta ... | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
50,
62
]
} | {
"id": "C0039663",
"name": "delta 9-thc",
"pos": [
300,
311
]
} |
results indicate that both timidity and olfaction inhibit the onset of maternal responses to pups in virgin males and females , but they differ in relative importance by age and gender . | NA | {
"id": "C0086582",
"name": "males",
"pos": [
108,
113
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
178,
184
]
} |
insulin substantially reduced the raised levels of cyclic amp and glycerol release prompted by isoproterenol and theophylline , but it had little effect on increases caused by dbcamp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
51,
61
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
176,
182
]
} |
this group was comprised primarily of subjects who also had fasting plasma glucose levels of less than or equal to 140 mg/dl , but subjects with impaired glucose tolerance without fasting hyperglycemia had hba1 levels that were not significantly higher than those with normal glucose tolerance . | NA | {
"id": "C0271650",
"name": "impaired glucose tolerance",
"pos": [
145,
171
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
188,
201
]
} |
renal hyperfunction and hypertrophy are characteristic findings in the early diabetic state , both in diabetes mellitus and in experimental diabetes . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
102,
119
]
} | {
"id": "C0011853",
"name": "experimental diabetes",
"pos": [
127,
148
]
} |
recently it has been paid attention whether the liver diseases might induce the disseminated intravascular coagulation ( dic ) or not , although it has well known that liver cirrhosis contribute to the hemorrhagic diathesis . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
48,
62
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
168,
183
]
} |
unexplained pulmonary problems complicating severe ulcerative colitis should prompt a review of rare etiologies to include pulmonary vasculitis , apical pulmonary fibrosis , and salicylazosulfapyridine-induced lung disease . | NA | {
"id": "C0034069",
"name": "pulmonary fibrosis",
"pos": [
153,
171
]
} | {
"id": "C0024115",
"name": "lung disease",
"pos": [
210,
222
]
} |
of these materials pectin had the greatest water-holding capacity ( 56.2 g water/g material ) but produced the smallest change in faecal weight ( 19 % ) , while bran had the lowest water-holding ( 4.2 g/g ) and the largest faecal weight changes ( 117 % ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
137,
143
]
} | {
"id": "C0005911",
"name": "weight changes",
"pos": [
230,
244
]
} |
analysis of serum fatty acid composition showed in general a reduction in unsaturated fatty acid and an increase in saturated fatty acid , especially in palmitic acid after ingestion of browning substances . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
18,
28
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
74,
96
]
} |
in 48-hour fasted rats , administration of the synthetic analogues pentagastrin , tetragastrin and gastrin-17 or naturally occurring molecular forms of human gastrin ( g-14 , g-34 ) markedly enhanced ( 23-123 % ) the capacity of the gastric mucosal ribosomes to synthesize endogenous mrna-directed protein in a cell-free... | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
67,
79
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
158,
165
]
} |
in 48-hour fasted rats , administration of the synthetic analogues pentagastrin , tetragastrin and gastrin-17 or naturally occurring molecular forms of human gastrin ( g-14 , g-34 ) markedly enhanced ( 23-123 % ) the capacity of the gastric mucosal ribosomes to synthesize endogenous mrna-directed protein in a cell-free... | NA | {
"id": "C0039659",
"name": "tetragastrin",
"pos": [
82,
94
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
158,
165
]
} |
sera of 7 patients with active acromegaly were fractionated by sephadex g-100 chromatography and the effects of bromocriptine on the concentrations of total growth hormone ( hgh ) and its different molecular forms studied . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
157,
171
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
174,
177
]
} |
the reversible denaturation and reduction with dithionite has been studied for the phycobiliproteins , c-phycocyanin ( 1 ) and allophycocyanin ( 2 ) from spirulina platensis , and c-phycoerythrin ( 4 ) from fremyella diplosiphon ( both cyanobacteria ) . | NA | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
83,
100
]
} | {
"id": "C0031789",
"name": "phycoerythrin",
"pos": [
182,
195
]
} |
the enzymes chorismate mutase , prephenate dehydratase and prephenate dehydrogenase are characterized and inhibition as well as repression are investigated . | NA | {
"id": "C0008514",
"name": "chorismate mutase",
"pos": [
12,
29
]
} | {
"id": "C0033068",
"name": "prephenate dehydratase",
"pos": [
32,
54
]
} |
the enzymes chorismate mutase , prephenate dehydratase and prephenate dehydrogenase are characterized and inhibition as well as repression are investigated . | NA | {
"id": "C0008514",
"name": "chorismate mutase",
"pos": [
12,
29
]
} | {
"id": "C0033069",
"name": "prephenate",
"pos": [
59,
69
]
} |
the frequencies of deficiencies of glutathione reductase ( gssg-r ) , pyruvate kinase ( pk ) and glucose-6-phosphate dehydrogenase ( g6pd ) in a spanish sample are presented . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
35,
46
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
59,
63
]
} |
loss malate dehydrogenase activity from isolated mitochondria was also accelerated by lps from e. coli o26 : b6 ( boivin preparation ) or salmonella typhosa o901 ( westphal preparation ) , and by lipid a from salmonella minnesota or shigella sonnei . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
86,
89
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
196,
203
]
} |
in addition , lps and lipid a inhibited state 3 respiration by isolated mitochondria with attendant loss of respiratory control , but adenosine 5'-diphosphate/o ratios were relatively unchanged . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
14,
17
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
22,
29
]
} |
impaired mitochondrial function is an early event after exposure to biologically relevant amounts of lps or lipid a . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
101,
104
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
108,
115
]
} |
the synthesis of several virus-specific proteins , including the nucleoprotein , membrane protein , and nonstructural 1 protein were detected , although no infectious virus was produced by the lymphocyte cultures . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
65,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
the synthesis of several virus-specific proteins , including the nucleoprotein , membrane protein , and nonstructural 1 protein were detected , although no infectious virus was produced by the lymphocyte cultures . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
81,
97
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
a small amount of a nitrosamine , n-nitrosodimethylamine ( dmn ) , was detected in the stomach after a single dose of nano2 . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
20,
31
]
} | {
"id": "C0012431",
"name": "dmn",
"pos": [
59,
62
]
} |
blood-sugar estimations after glucose-loading were performed on a sample of a village population 15 + years . | NA | {
"id": "C0005802",
"name": "blood-sugar",
"pos": [
0,
11
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
30,
37
]
} |
on hydrolysis , p1 showed a carbohydrate content of 26.22 % when the monosaccharides were analyzed by gas liquid chromatography ; | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
28,
40
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
69,
84
]
} |
groups of patients of either sex , with pain indication of trigeminal neuralgia , tension headache or postherpatic neuralgia , received doses of clomipramine or amitriptyline in a single blind clinical experiment . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
40,
44
]
} | {
"id": "C0027796",
"name": "neuralgia",
"pos": [
115,
124
]
} |
emphysematous cholecystitis is a rare form of acute cholecystitis , characterized radiographically by the presence of gas within the gallbladder . | NA | {
"id": "C0521610",
"name": "emphysematous cholecystitis",
"pos": [
0,
27
]
} | {
"id": "C0149520",
"name": "acute cholecystitis",
"pos": [
46,
65
]
} |
in non-damaged osteoblasts and growth-plate chondrocytes dense precipitate had accumulated along the plasmalemma and the mitochondrial membranes , whereas damaged cells showed the precipitate on round granules in the mitochondrial matrix but not on membranes . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
44,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
163,
168
]
} |
the growth of streptococcus mutans atcc 25 175 has been studied in the presence of various sugars ( sorbitol , mannitol , lycasin , sorbose and xylitol ) and compared to sucrose , glucose and fructose , added to a complex and a synthetic culture medium . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
91,
97
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
170,
177
]
} |
in the absence of a change in alpha helix in the apolipoproteins studied here , the enthalpy of association is practically nil , suggesting that alpha helix formation is a major enthalpic contribution to the total free energy of lipid-apolipoprotein association . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
49,
64
]
} | {
"id": "C0003592",
"name": "a",
"pos": [
256,
257
]
} |
with a concentration of 0.08 microm [ 14c ] riboflavin in the incubation medium , 28 % of the [ 14c ] riboflavin within the choroid plexus was converted to [ 14c ] fad or [ 14c ] fmn intracellularly . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
44,
54
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
179,
182
]
} |
both primer synthesis and dna synthesis are stimulated 3- to 5-fold by the presence of either escherichia coli or t7 helix-destabilizing protein ( dna binding protein ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
137,
144
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
147,
166
]
} |
provided that t7 dna polymerase is present , rna-primed dna synthesis occurs on either duplex or single-stranded dna templates and to equal extents on either strand of t7 dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
97,
116
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
171,
174
]
} |
the proteoglycans synthesized by cells in a culture maintained on xyloside until day 8 , and then switched to medium with no xyloside 1 h prior to labeling , were characteristic of those synthesized by normal mature day 8 chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
33,
38
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
222,
234
]
} |
treatment of embryonic chick heart fibroblast cultures with 0.2 m urea reversibly increases cellular overlap . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
35,
45
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
92,
100
]
} |
these results indicate that external macromolecules other than fibronectin are synthesized by cultured fibroblasts and can affect cell social behavior or culture morphology . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
130,
134
]
} |
the three xanthine derivatives , caffeine , theophylline and 3-isobutyl-1-methyl-xanthine ( ibmx ) produced dose-dependent increases in cyclic amp concentrations in hela cells after long term treatment . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
44,
56
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methyl-xanthine",
"pos": [
61,
89
]
} |
the recent occurrence at the port-royal obstetrics and gynaecology center of three cases of interstitial pregnancy out of a total number of 208 ectopic pregnancies give us the opportunity to discuss the diagnosis and present management of the rarest form of tubal pregnancies . | NA | {
"id": "C1401136",
"name": "interstitial pregnancy",
"pos": [
92,
114
]
} | {
"id": "C0032994",
"name": "tubal pregnancies",
"pos": [
258,
275
]
} |
discordant responses of thyrotropin and its free alpha- and beta-subunits after thyrotropin-releasing hormone with incremental thyroid hormone replacement in primary hypothyroidism . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
24,
35
]
} | {
"id": "C0076641",
"name": "beta-subunits",
"pos": [
60,
73
]
} |
radioimmunoassay of a basic somatomedin : comparison of various assay techniques and somatomedin levels in various sera . | NA | {
"id": "C0021666",
"name": "a",
"pos": [
1,
2
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
85,
96
]
} |
purification of a basic somatomedin ( sm ) , with similarity to sm-c and insulin-like growth factor , from human plasma cohn fraction iv-1 enabled development of a ria based on this sm.sm antiserum was produced by immunizing rabbits with partially purified sm . | NA | {
"id": "C0021666",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0037657",
"name": "sm",
"pos": [
257,
259
]
} |
purification of a basic somatomedin ( sm ) , with similarity to sm-c and insulin-like growth factor , from human plasma cohn fraction iv-1 enabled development of a ria based on this sm.sm antiserum was produced by immunizing rabbits with partially purified sm . | NA | {
"id": "C0021665",
"name": "sm-c",
"pos": [
64,
68
]
} | {
"id": "C0037657",
"name": "sm",
"pos": [
257,
259
]
} |
highly purified sm-c , insulin-like growth factor 1 , and our sm revealed parallel and approximately equipotent dose-response curves in this ria ; | NA | {
"id": "C0021665",
"name": "insulin-like growth factor 1",
"pos": [
23,
51
]
} | {
"id": "C0037657",
"name": "sm",
"pos": [
62,
64
]
} |
as the concentration of f- in the o2- generating system increased beyond 10 mm , a rise in production of o2- anion occurred , peaking at 20 mm f- , followed by a rapid decline . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
109,
114
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
148,
149
]
} |
a fluorescein angiography of the optic disc has been performed on 62 eyes in 41 patients suffering from ocular hypertension or glaucoma . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
104,
123
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
127,
135
]
} |
the effects of acute oral administration of the dopaminergic drug , bromocriptin ( 5 mg ) , on basal and submaximal ( 1 and 3 microgram per kg bw given sc ) and maximal ( 6 mug per kg bw ) pentagastrin-stimulated gastric acid secretion and on basal and meal-induced gastrin release have been evaluated in healthy volunte... | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
189,
201
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
266,
273
]
} |
it is concluded that igm+ , igd+ , igg- cells constitute the major lps-sensitive cell population in the low cell density culture system and that igg is not a necessary cell surface isotype for precursors of igg-secreting cells . | NA | {
"id": "C0020843",
"name": "igd",
"pos": [
28,
31
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
181,
188
]
} |
peritoneal macrophages from the endotoxin-unresponsive c3h/hej substrain of mice were entirely refractory to activation in vitro by protein-free lps , a defect that was not overcome by co-culture of spleen cells from the responder c3h/st substrain with lps resistant c3h/hej macrophages . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
32,
41
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
253,
256
]
} |
the defect in responsiveness appears confined to the lipid a activation signal since c3h/hej macrophages were fully activated after in vitro treatment by lipid a protein ( lap ) -- lps complex , isolated lap , and bcg . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
181,
184
]
} | {
"id": "C0023767",
"name": "lap",
"pos": [
204,
207
]
} |
c3h/hej macrophages , therefore , exhibit a highly selective defect characterized by unresponsiveness to the lipid a activation signal of protein-free lps and resistance to the toxic effects of high concentrations of lps that were lethal to the responder c3h/st strain . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
109,
116
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
217,
220
]
} |
we have developed a simple method which can recover the highly purified macrophages or monocytes in suspension from mouse peritoneal exudate cells and human perpheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
167,
190
]
} |
we have studied the binding of rabbit antibody to cultured synovial fibroblasts by 3 methods : complement mediated cell lysis , 125i-labeled staphylococcal protein a ( [ 125i ] pra ) and antibody dependent cell mediated cytotoxicity ( adcc ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
206,
210
]
} |
radioiodinated sod-1 is incubated with unlabeled competitor and limiting antibody , then immune complexes are isolated using staphylococcus aureus . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
73,
81
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
89,
105
]
} |
apolipoprotein b : its role in the control of fibroblast cholesterol biosynthesis and in the regulation of its own binding to cellular receptors . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
126,
134
]
} |
accordingly , fibroblast cholesterol synthesis and the number of functional ldl receptors are not suppressed by the binding of the apoprotein to the receptor , and the known role of apob remains that of transporting cholesterol in plasma and delivering it to the cell . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
263,
267
]
} |
apolipoprotein b : its role in the control of fibroblast cholesterol biosynthesis and in the regulation of its own binding to cellular receptors . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
126,
134
]
} |
gm2 and ga2 gangliosides from the brain of a patient who died of sandhoff 's disease were purified by solvent partition , silicic acid and silica gel column chromatography , and silica gel preparative thin-layer chromatography . | NA | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
122,
134
]
} | {
"id": "C2936385",
"name": "silica gel",
"pos": [
178,
188
]
} |
in the latter procedure the ions at m/e 605 and 607 ( specific for the derivatives of unlabeled and labeled 18-hydroxycorticosterone , respectively ) , at m/e 591 and 593 ( specific for the derivatives of unlabeled labeled aldosterone , respectively ) and at m/e 548 and 550 ( specific for the derivatives of unlabeled a... | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
108,
132
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
331,
345
]
} |
from the ratio between the peaks obtained in the mass fragmentography and from the percentage conversion of [ 4-14c ] corticosterone obtained in the thin-layer radiochromatography , the amount of endogenous and exogenous 18-hydroxycorticosterone and aldosterone could be calculated . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
118,
132
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
221,
245
]
} |
it was ascertained that the 18-hydroxycorticosterone and aldosterone formed in the incubations were derived from corticosterone . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
28,
52
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
113,
127
]
} |
apoproteins of high density lipoproteins were detected in the urine of normal subjects after the urinary proteins were highly concentrated . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
0,
11
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
105,
113
]
} |
the interaction of sonicated , small vesicles of egg phosphatidylcholine and cholesterol ( 2:1 , mol/mol ) with bovine high density serum lipoproteins was examined in terms of lipid transfer between both types of particles and the resulting changes in lipoprotein structure . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
176,
181
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
252,
263
]
} |
saturation of high density lipoprotein preparations with vesicle lipids gave final lipoprotein particles with essentially unchanged protein content and composition , unchanged cholesterylester and nonpolar lipid content , but with markedly increased phospholipid content ( 59 % increas by weight ) and moderately increas... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
27,
38
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
257,
262
]
} |
the lipoproteins enriched in lipid were relatively uniform , spherical particles , 110 +/- 3.6 a in diameter ( 6 a larger than the original lipoproteins ) ; | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
4,
16
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
29,
34
]
} |
the lipoproteins enriched in lipid were relatively uniform , spherical particles , 110 +/- 3.6 a in diameter ( 6 a larger than the original lipoproteins ) ; | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
4,
16
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
137,
138
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.