text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these results indicate that the direct addition of excess lipids from membranes or other lipoproteins is a possible mechanism for lipid transfer to high density lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
58,
64
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
161,
173
]
} |
nevertheless , cell-associated fatty acids were increased in cultured cells and ffa/albumin ratios in the medium often reached potentially toxic levels . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
31,
42
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
80,
83
]
} |
3-hydroxy-3-methylglutaryl coenzyme a reductase ( hmg-coa reductase , e.c . 1.1.1.34 ) , the major rate-limiting enzyme of the sterol biosynthetic pathway , was studied in ileal epithelial cells isolated in a villus-to-crypt gradient according to weiser ( weiser , m . | NA | {
"id": "C0063164",
"name": "3-hydroxy-3-methylglutaryl coenzyme a reductase",
"pos": [
0,
47
]
} | {
"id": "C0020374",
"name": "hmg-coa reductase",
"pos": [
50,
67
]
} |
the thrombolytic effects of plasminogen activators ( urokinase , streptokinase ) , and plasmin preparations with activator activity ( streptokinase-activated human plasmin ) and without activator activity ( trypsin-activated porcine plasmin , lysofibrin ) were studied . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
28,
50
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
134,
147
]
} |
the effects of allopurinol in terms of specific pigmentary alterations were examined , and a new method for analyzing heterogeneous extracts of skin pigments ( e.g. , purines and pteridines ) is presented . | NA | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
15,
26
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
167,
174
]
} |
stimulation induced the release of norepinephrine , epinephrine and dopamine into the lumen of the perfused , isolated heart . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
35,
49
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
52,
63
]
} |
[ comparison of serum glutamic oxalacetic transaminase , glutamic pyruvic transaminase , alkaline phosphatase activities measured by sma 12/60 , hitachi 716 , centrifichem 400 and manual method ( author 's transl ) ] . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
42,
54
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic",
"pos": [
57,
73
]
} |
these subtle correlations between hbsag titer and subtype and aaa suggest that the human serum albumin ( hsa ) known to exist on the hbsag particles may be similar in a modified form , to that representing aaa specificity . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
83,
102
]
} | {
"id": "C0001924",
"name": "aaa",
"pos": [
206,
209
]
} |
serial blood levels of diazepam and desmethyldiazepam were acquired and found to yield significant levels of desmethyldiazepam for 21 days and greater than trace amounts for 30 days . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
23,
31
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
109,
126
]
} |
phenylalanine , p-chlorophenylalanine , tyrosine , 3,4-dihydroxyphenylalanine and kynurenine as well as leucine , isoluecine and valine all inhibited the net uptake of tryptophan . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
0,
13
]
} | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
16,
37
]
} |
human cells lack the c system and have two alternative neutral amino acid transport mechanisms : the l system which is selective for large hydrophobic amino acids and a na-dependent alanine-cysteine system . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
151,
162
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
182,
189
]
} |
in order to investigate possible disturbances of the blood-brain transport mechanisms of monoamine precursors in manic-depressive illness and schizophrenia , we have measured the brain arterio-venous difference of dopa , or 5-htp , or tyrosine and tryptophan in 36 patients , during the infusion of either l-dopa or l-5-... | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
214,
218
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
306,
312
]
} |
in order to investigate possible disturbances of the blood-brain transport mechanisms of monoamine precursors in manic-depressive illness and schizophrenia , we have measured the brain arterio-venous difference of dopa , or 5-htp , or tyrosine and tryptophan in 36 patients , during the infusion of either l-dopa or l-5-... | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
224,
229
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
248,
258
]
} |
tryptophan and 5-hydroxytryptophan administration to patients with post-hypoxic intention myoclonus increases pre-existing low levels of 5-hydroxyindoleacetic acid levels in the cerebrospinal bluid , and also suppresses myoclonus . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
0,
10
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
15,
34
]
} |
the effect of food intake on the competitive uptake of tryptophan into brain , and on brain tryptophan levels , has recently been shown not to be limited to this amino acid , but also holds for other large neutral amino acids , and for certain large neutral amino acid drugs ( e.g. , methyldopa ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
162,
172
]
} | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
250,
268
]
} |
hence , following a meal , the brain concentration of any large neutral amino acid appears to depend on how the food modifies the plasma level of that amino acid relative to the plasma concentrations of its competitors . | NA | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
64,
82
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
151,
161
]
} |
the basal laminae are also attached to fibroblasts , fibroblast-like perineurial cells and elastic laminae , and the whole cellular and extracellular system appears to be tightly bound together . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
39,
49
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
141,
149
]
} |
in vivo studies in chicks and rats of bone calcium mobilization by 1 alpha,25-dihydroxycholecalciferol ( calcitriol ) and its congeners . | NA | {
"id": "C0012328",
"name": "dihydroxycholecalciferol",
"pos": [
78,
102
]
} | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
105,
115
]
} |
the alloy ney cast iii is superior in performance to the other low golds and approximately equivalent to the high-gold alloy firmilay . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
4,
9
]
} | {
"id": "C0018027",
"name": "gold",
"pos": [
114,
118
]
} |
it is competitively inhibited by d-proline as well as by alanine , methionine , valine , azetidine-2-carboxylate , thioproline , 3,4-dehydropoline , hydroxyproline and alpha-aminoisobutyric acid . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
35,
42
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
149,
163
]
} |
this hypothesis accounts for the improvement in class-inclusion performance with changes in wording of the question and for the finding that young children 's response to class-inclusion questions and to ungrammatical requests for comparison of an element of a class and an element of an included subclass are similar : ... | NA | {
"id": "C0728836",
"name": "young children 's",
"pos": [
141,
158
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
324,
332
]
} |
glc during auranofin administration ( 6 mg/day p.o . ) approached values for im gold despite significantly lower plasma levels . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
11,
20
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
80,
84
]
} |
after oral administration of auranofin ( sk & f d-39162 ) , a new antiarthritic gold compound , to rats , dogs and humans , a major portion ( approximately 50 % ) of the blood gold content was found to be associated with cellular components . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
29,
38
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
176,
180
]
} |
although the clinical significance of this property is not presently known , it is recommended that pharmacokinetic studies involving auranofin include the assessment of both blood and serum gold levels . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
134,
143
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
191,
195
]
} |
blood gold levels are 3 to 10 fold higher with injectable aurothioglucose and gold sodium thiomalate ( 50 mg/week ) than with oral auranofin ( 6 mg/day ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
6,
10
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
58,
73
]
} |
blood gold levels are 3 to 10 fold higher with injectable aurothioglucose and gold sodium thiomalate ( 50 mg/week ) than with oral auranofin ( 6 mg/day ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
6,
10
]
} | {
"id": "C0018034",
"name": "gold sodium",
"pos": [
78,
89
]
} |
blood gold levels are 3 to 10 fold higher with injectable aurothioglucose and gold sodium thiomalate ( 50 mg/week ) than with oral auranofin ( 6 mg/day ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
6,
10
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
131,
140
]
} |
blood gold levels are 3 to 10 fold higher with injectable aurothioglucose and gold sodium thiomalate ( 50 mg/week ) than with oral auranofin ( 6 mg/day ) . | NA | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
58,
73
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
131,
140
]
} |
a more detailed analysis of aurosomes found in the synovial membrane 3 days and 18 months after injection of gold sodium thiomalate into the rabbit knee joint revealed that the aurosome contains gold , phosphorus , and sulphur , and that the atomic ratios of these elements do not alter over the above mentioned time int... | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
202,
212
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
265,
273
]
} |
preliminary observations suggest that the frequency of common side-effects ( e.g . dermatitis , stomatitis , proteinuria ) from oral gold ( auranofin ) is less than that incurred with intramuscular gold prepartions . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
140,
149
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
198,
202
]
} |
thirty-nine subjects with classical or definite rheumatoid arthritis received weekly intramuscular gold sodium thiomalate ( gst ) to sustain gold blood levels of more than 320 microgram/dl . | NA | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
99,
121
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
141,
145
]
} |
although neither of the compounds possessed dopaminergic activity in the canine renal blood-flow model , both agents were weak alpha-adrenergic agonists and exhibited cardiostimulatory properties similar to dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
44,
56
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
207,
215
]
} |
acylation of the sodio anion of beta-tetralone with phenyl anisoate , followed by a grignard reaction of the resultant 4 with 4-methoxyphenylmagnesium bromide , gave rise to two novel dihydronaphthalene isomers 5 and 6 . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
23,
28
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
151,
158
]
} |
the rate of debenzylation was decreased by substituting deuterium for hydrogen in the methylene portion of the benzyl group . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
56,
65
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
70,
78
]
} |
a primary isotope effect of 1.46 was observed when the methylene hydrogens of benzyl were replaced by deuterium . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
65,
74
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
102,
111
]
} |
no secondary isotope was observed when the aromatic hydrogens of benzyl were replaced by deuterium . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
52,
61
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
89,
98
]
} |
the lateral mobility of pyrene , pyrene decanoic acid , and 1-palmitoyl-2-pyrene decanoyl-phosphatidyl choline ( pyrene lecithin ) in lipid bilayers is determined by the excimer formation technique . | NA | {
"id": "C1959616",
"name": "phosphatidyl choline",
"pos": [
90,
110
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
120,
128
]
} |
by using cell-free preparations of uteri obtained from immature balb/c mice , it was demonstrated that zearalenone and zearalanol , fusarium mycotoxins , inhibited [ 3h ] estradiol-17 beta binding to specific sites in cytosol . | NA | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
103,
114
]
} | {
"id": "C0043465",
"name": "zearalanol",
"pos": [
119,
129
]
} |
significant inhibition was noted from zearalenone at 4 x 10 ( -6 ) m and from zearalanol at 4 x 10 ( -7 ) m . | NA | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
38,
49
]
} | {
"id": "C0043465",
"name": "zearalanol",
"pos": [
78,
88
]
} |
abdominal fat tissue samples from the general population of greenland and from southern denmark were analyzed for o , p'-dde and p , p'-dde [ 1,1-dichloro-2,2-bis ( p-chlorophenyl ) ethylene ] , p , p , -ddt [ 1,1,1-trichloro-2,2-bis ( p-chlorophenyl ) -ethane ] , o , p'-ddt and p , p'-ddd [ 1,1-dichloro-2,2-bis ( p-ch... | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
610,
620
]
} | {
"id": "C0019220",
"name": "heptachlor",
"pos": [
692,
702
]
} |
lindane , aldrin-like residue , dieldrin heptachlor-like residue , heptachlor epoxide , and pcbs were present in adipose tissue of both groups and there were no significant differences between the groups . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
41,
51
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
67,
85
]
} |
it was found that the concentrated water induced mutagenicity in hamster lung cells and cellular transformation in human embryonic lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
136,
147
]
} |
[ a study of serum concentration in children administered by intravenous injection of cefazolin . i. evaluation about speciality of serum concentration in school children , young children and infants ( author 's transl ) ] . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
36,
44
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
173,
187
]
} |
[ comparison of antibacterial activity of mecillinam against recently isolated bacilli of 5 genera of enterobacteriaceae from clinical materials with ampicillin , amoxicillin , cephalexin , nalidixic acid and pipemidic acid ( author 's transl ) ] . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
150,
160
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
163,
174
]
} |
an attempt to prevent epidemics of hemorrhagic pneumonia in mink due to pseudomonas aeruginosa was made in the course of epidemics with injection of the multicomponent vaccine consisting of common protective antigen ( oep ) of p. aeruginosa mixed with toxoids of protease and elastase of the bacillus . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
168,
175
]
} | {
"id": "C0040555",
"name": "toxoids",
"pos": [
252,
259
]
} |
this probably indicates that the condition of either an excess of ca or a reduction of na in ringer solution is apparently a cooperative effector of the inhibitory action of nem , suggesting that the carrier protein responsible for the generation of tonic tension may be an allosteric protein . | NA | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
200,
215
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
285,
292
]
} |
in the presence of verapamil or methoxyverapamil ( d 600 ) the tonic contraction , but not the phasic contraction , could be evoked by a single strong stimulus , while in the presence of sodium nitroprusside the phasic contraction , but not the tonic contraction , could be provoked by a single strong stimulus . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
19,
28
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
32,
48
]
} |
the effects of gastrointestinal hormones and similar substance , caerulein , tetragastrin and secretin were investigated on the activity . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
15,
40
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
94,
102
]
} |
by using the isolated seminal vesicles of guinea pigs , the effects of dibutyryl cyclic amp and beta-stimulant , orciprenaline , on the responses to ca , k , acetylcholine and ba were investigated , especially in relation to cyclic amp . | NA | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
71,
80
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
225,
235
]
} |
in the setting of chronic pulmonary sarcoidosis with mycetoma formation , fatal hemoptysis is infrequent and episodes of hemorrhage may be safely managed with supportive medical therapy alone . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
80,
90
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
121,
131
]
} |
the severest affections of the heart muscle , stenosing coronarosclerosis and disorders of microcirculation in different zones of the heart were encountered in patients with myocardial infarction marked by a recurrent course and complicated by cardiogenic shock or congestive circulatory insufficiency . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
174,
195
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
244,
261
]
} |
considerable hyperadrenalia was determined when myocardial infarction was complicated by acute cardiac insufficiency , cardiogenic shock or acute disorders of rhythm . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
48,
69
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
119,
136
]
} |
rhe appearance of 14c-hydroxyproline in the basement membrane matrix was negligible during the first 4 hours of incubation and rose only to 1 % of the total proline counts thereafter . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
22,
36
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
157,
164
]
} |
it is a considerable advantage in glaucoma therapy to diminish or to avoid systemic and local side effects of epinephrine due to very low concentrations of dipivalyl-epinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0058415",
"name": "dipivalyl-epinephrine",
"pos": [
156,
177
]
} |
lipid-protein interactions in membranes : effect of lipid composition on mobility of spin-labeled cysteine residues in yeast plasma membrane . | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
52,
57
]
} |
these observations indicate that while the spin-labeled residues are not in direct contact with the lipid core of the membrane , there are lipid-protein interactions to the extent that removal of the polar portion of the bulk of phospholipids induces conformational changes in proteins , which in turn restrict mobility ... | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
100,
105
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
236,
241
]
} |
these observations indicate that while the spin-labeled residues are not in direct contact with the lipid core of the membrane , there are lipid-protein interactions to the extent that removal of the polar portion of the bulk of phospholipids induces conformational changes in proteins , which in turn restrict mobility ... | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
100,
105
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
229,
242
]
} |
the second step occurs only with cells that are without an available electron acceptor , are fermenting , and which have a functional membrane-bound , ca2+-dependent adenosine triphosphatase ( atpase ) . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
151,
154
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
193,
199
]
} |
lower peak blood ethanol concentrations after 1 and 2 g of ethanol per kg were found in pregnant rats than in virgin females . | NA | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
11,
39
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
59,
66
]
} |
in vitro two proteins of the contractile apparatus are phosphorylated by 3',5'-amp dependent protein kinases . | NA | {
"id": "C0009915",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
93,
100
]
} |
the t and b lymphocyte populations were determined as well as the serum levels of immunoglobulins and acid alpha-1-glycoprotein as acute phase reactants . | NA | {
"id": "C0029297",
"name": "acid alpha-1-glycoprotein",
"pos": [
102,
127
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
131,
152
]
} |
follow-up of one pre-eclamptic woman throughout pregnancy showed important immune changes at the beginning of the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
48,
57
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
114,
130
]
} |
by contrast , in 60 % of cholesterol-rich areas from more advanced plaques , fibrin ( mean concentration 22.7 mg/100 mg lipid-extracted dry weight ) was ten times higher than normal , and this was associated with a twelve-fold increase in a bound lp fraction that was released by incubation with fibrinolytic enzymes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
120,
125
]
} | {
"id": "C0023820",
"name": "lp",
"pos": [
247,
249
]
} |
for the previous 35 days single-stranded dna ( ssdna ) antibody and immune-complex levels had been continuously raised with only partial improvement on prednisone therapy . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} | {
"id": "C0003313",
"name": "immune-complex",
"pos": [
68,
82
]
} |
levels of immune complexes and ssdna antibodies were substantially reduced by extracorporeal plasma filtration and adsorption of dna collodion charcoal . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
10,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
37,
47
]
} |
evidence for reduced uptake of asialo-alpha 1-acid glycoprotein during the acute phase response to inflammation . | NA | {
"id": "C0001349",
"name": "acute",
"pos": [
75,
80
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
99,
111
]
} |
modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol , propoxyphene , and methadone . | NA | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
101,
115
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
137,
146
]
} |
it is shown that the shorter chain ( c14-c18 ) minor fatty alcohols in copepods , fish body lipids , and commercial fish oils are all qualitatively present , and quantitatively similar in proportions to acids found in the depot fats of capelin and mackerel , and in some herring . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
92,
98
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
228,
232
]
} |
the fatty acids recovered from the triglycerides and wax esters of common northwest atlantic copepods are compared with the fatty acids of wax esters recovered intact from certain fish skin and body lipid , and from commercial fish oils . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
53,
56
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
199,
204
]
} |
selectivity factors are discussed in comparing the copepod wax ester fatty acids with the fatty acids of the wax esters recovered intact from the fish lipids and oils . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
59,
62
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
151,
157
]
} |
selectivity factors are discussed in comparing the copepod wax ester fatty acids with the fatty acids of the wax esters recovered intact from the fish lipids and oils . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
151,
157
]
} | {
"id": "C0028908",
"name": "oils",
"pos": [
162,
166
]
} |
in skeletal muscle , the kinetics of vo2 closely follow those of the concentrations of creatine phosphate and free creatine : a sensor of either of these concentrations could thus theoretically serve as a useful `` '' metaboreceptor '' '' . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
87,
105
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
115,
123
]
} |
cigarette smoking , alcohol intake , and oral contraceptives : relationships to lipids and lipoproteins in adolescent school-children . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
80,
86
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
91,
103
]
} |
an examination of the effect of the aminoglycoside antibiotics paromomycin and neomycin on mitochondrial ribosome function in yeast has been made . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
63,
74
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
79,
87
]
} |
at lower concentrations ( about 10 microgram/ml ) , paromomycin and neomycin cause a 2-3 fold stimulation in the extent of misreading of the uuu codons in poly u , over and above the significant level of misreading catalyzed by the ribosomes in the absence of drugs . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
52,
63
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
68,
76
]
} |
comparative studies have been made between a paromomycin sensitive strain d585-11c and a mutant strain 4810p carrying the par l-r mutation in mtdna , which leads to high resistance to both paromomycin and neomycin in vivo . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
45,
56
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
205,
213
]
} |
whilst the degree of resistance of isolated mitochondrial ribosomes from strain 4810p judged by the inhibition of polyphenylalanine synthesis by paromomycin and neomycin is not extensive , studies on misreading of the poly u message promoted by these drugs demonstrate convincingly the altered properties of mitochondria... | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
145,
156
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
161,
169
]
} |
these ribosomes show resistance to the stimulation of misreading of the codon uuu brought about by paromomycin and neomycin in wild-type mitochondrial ribosomes . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
99,
110
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
115,
123
]
} |
although strain 4810p was originally isolated as being resistant to paromomycin , in all the in vitro amino acid incorporation systems tested here , the 4810p mitochondrial ribosomes show a higher degree of resistance to neomycin than to paromomycin . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
221,
229
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
238,
249
]
} |
the paper contains an account of the use of hoffmann 's violet-so2 under exposure to uv rays during staining acid-hydrolysed dna of mammalian tissue nuclei . | NA | {
"id": "C0028606",
"name": "acid",
"pos": [
109,
113
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
125,
128
]
} |
these differences in lipid composition suggested that modification of membrane lipids may occur as an adaptational change in response to the disappearance of the cell wall . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
21,
26
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
70,
85
]
} |
although studies on the molecular nature of thymus-independent antigens suggested that the polymeric structure with repeated antigenic determinants and slow metabolism are responsible for thymus-independence , we found that anti-dnp antibody responses to dnp-casein and dnp-gelatin were thymus-independent as well as mac... | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
63,
71
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
125,
147
]
} |
a decreased sialic acid content has been observed in cell surface glycoproteins on cystic fibrosis fibroblasts and in numerous soluble glycoprotein preparations from cystic fibrosis homozygotes . | NA | {
"id": "C0025248",
"name": "cell surface glycoproteins",
"pos": [
53,
79
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
135,
147
]
} |
risk factors such as adenomatous polyps and family history of colorectal cancer were more common than inflammatory bowel disease and polyposis coli . | NA | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
21,
39
]
} | {
"id": "C0032580",
"name": "polyposis coli",
"pos": [
133,
147
]
} |
the use of tetrabenazine to treat the movement disorder of huntington 's chorea and other dyskinesias is described . | NA | {
"id": "C0026650",
"name": "movement disorder",
"pos": [
38,
55
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
90,
101
]
} |
the separation of the total ck enzymes into the isoenzymes ck-mm , ck-bb , and ck-mb showed a marked difference between the photometric and the immunological method . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
31,
38
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
48,
58
]
} |
chick embryo fibroblast cells treated with the mixture of interferon and chinoform were more sensitive to sindbis virus infection than cells treated with interferon alone . | NA | {
"id": "C0016030",
"name": "fibroblast cells",
"pos": [
13,
29
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
135,
140
]
} |
a comparison of the hybridization values obtained from steady state nuclear rna and pulse labeled newly synthesized nuclear rna demonstrated , that ( a ) there is a vast excess of globin gene transcripts over other individual protein coding transcripts and ( b ) the ratio of globin gene transcripts to the amount of oth... | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
68,
79
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
379,
382
]
} |
moreover , an accumulation of both types of transcripts was observed , as the contents of these rna molecules was higher within steady state nuclear rna than within the newly synthesized rna . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
141,
152
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
187,
190
]
} |
furthermore , these receptors exhibit significant quantitative differences in various subtypes of human leukemia , with null-cell lymphoblastic leukemia having approximately three times the mean number of receptors per cell as t-cell leukemias . | NA | {
"id": "C0023448",
"name": "lymphoblastic leukemia",
"pos": [
130,
152
]
} | {
"id": "C0023492",
"name": "cell",
"pos": [
229,
233
]
} |
the plasma catecholamines noradrenaline and adrenaline , the blood pressure and heart rate were monitored before and after premedication . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
26,
39
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
44,
54
]
} |
the agents chosen for comparative analysis were the nitrosamides enu and mnu , the methanesulfonic esters ipms , ems and mms , the dialkylsulfate dms , and the nitrosamines den and dmn . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
160,
172
]
} | {
"id": "C0012431",
"name": "dmn",
"pos": [
181,
184
]
} |
the case history of a patient with severe muscular weakness resulting from magnesium intoxication following oral and rectal administration of magnesium citrate cathartics is reported . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
75,
84
]
} | {
"id": "C0126774",
"name": "magnesium",
"pos": [
142,
151
]
} |
the reaction product with highest radioactivity was palmitic acid , and the free fatty acids of nerve contained 90 % of the total fatty acid label . | NA | {
"id": "C0015688",
"name": "free",
"pos": [
76,
80
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
130,
140
]
} |
we studied a five-year-old girl with several autoimmune disorders and a 16-year-old boy with acquired agammaglobulinemia to determine whether aberrations of immunoregulatory t cells could explain some instances of immunodeficiency or autoimmunity . | NA | {
"id": "C0009447",
"name": "acquired agammaglobulinemia",
"pos": [
93,
120
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
214,
230
]
} |
nal induces nal-resistant mutants in very high frequency but only at 37 c on plates containing i ) glucose as primary carbon source and ii ) adenine , a sulfur amino acid or a representative of the glutamic acid family of amino acids . | NA | {
"id": "C0002527",
"name": "sulfur amino acid",
"pos": [
153,
170
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
222,
233
]
} |
histopathologically , the tumors were classified as adenomas and adenocarcinomas of lungs , benign hepatomas and liver cell carcinomas , angiomas and angiosarcomas of blood vessels , adenomas and adenocarcinomas of gall bladder and cholangiomas . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
52,
60
]
} | {
"id": "C0008309",
"name": "cholangiomas",
"pos": [
232,
244
]
} |
one such process is the active extrusion of calcium from the cell by a high affinity calcium-stimulated atpase ( ca2+-atpase ) . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
104,
110
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
113,
116
]
} |
we have identified a high affinity ca2+-atpase in a plasma membrane-enriched subcellular fraction isolated from rat adipocytes which may provide the enzymatic basis for a calcium extrusion pump . | NA | {
"id": "C0300252",
"name": "ca2",
"pos": [
35,
38
]
} | {
"id": "C0001476",
"name": "calcium",
"pos": [
171,
178
]
} |
it has previously been shown that the hs puff induction is accompanied by a local increase of nuclear nonhistone proteins ( nhp ) but the nature of most of the proteins accumulating is unknown . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
94,
101
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
160,
168
]
} |
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