text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the bee venom toxin apamin inhibited the nt-induced relaxation while inhibition of prostaglandin synthesis by indomethacin abolished the contraction phase . | NA | {
"id": "C0004920",
"name": "bee venom",
"pos": [
4,
13
]
} | {
"id": "C0003521",
"name": "apamin",
"pos": [
20,
26
]
} |
the potencies of alpha-adrenergic compounds to displace [ 3h ] clonidine binding ranked as follows : yohimbine greater than phentolamine much greater than prazosin for antagonists and clonidine greater than epinephrine greater than norepinephrine greater than phenylephrine much greater than amidephrine for agonists . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
207,
218
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
232,
246
]
} |
when tested on intact cells , epinephrine , norepinephrine and clonidine were found to counteract , in a dose-dependent manner , the increase of cyclic amp triggered by vasoactive intestinal peptide ( vip ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} |
the physiological amines were the most efficient agonists : both epinephrine and norepinephrine inhibited vip-induced cyclic amp accumulation by 50-55 % with kd values of 50 nm and 300 nm respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
81,
95
]
} |
it was decreased by various adenosine receptor agonists in an order of potency that was typical for a1- ( ri- ) receptors : n6-cyclohexyladenosine greater than ( - ) n6-phenylisopropyladenosine greater than 5'-n-ethylcarboxamideadenosine greater than ( + ) n6-phenylisopropyladenosine = adenosine . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
169,
193
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
287,
296
]
} |
in similarly pretreated membranes , the binding of [ 3h ] methionine enkephalin [ 3h ] [ d-ala2 , d-leu5 ] enkephalin ( dadle ) or [ 3h ] ethylketazocine was reduced to a smaller extent . | NA | {
"id": "C0014295",
"name": "methionine enkephalin",
"pos": [
58,
79
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
107,
117
]
} |
adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine all relaxed the bronchial artery . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
0,
11
]
} | {
"id": "C0001413",
"name": "adenosine",
"pos": [
110,
119
]
} |
adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine all relaxed the bronchial artery . | NA | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
0,
11
]
} | {
"id": "C0001413",
"name": "adenosine",
"pos": [
110,
119
]
} |
dipyridamole ( 10 ( -6 ) m ) enhanced the relaxations due to adenosine and atp while theophylline ( 10 ( -6 ) m ) inhibited the relaxations due to adenosine and atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
61,
70
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
161,
164
]
} |
the effects of cyclic amp , dibutyryl cyclic amp , theophylline , isoproterenol and propranolol on mesaconitine ( ma ) -induced antinociception in mice were investigated employing the tail flick and acetic acid-induced writhing methods for the evaluation of antinociceptive activity . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
15,
25
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
28,
48
]
} |
in human blood platelets verapamil and d600 ( 2-methoxyverapamil ) in therapeutic concentrations inhibited the shape change reaction induced by 5-hydroxytryptamine ( 5ht ) but not that induced by adp . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
25,
34
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
48,
64
]
} |
monoclonal antibodies were generated by immunizing rats with mouse bladder carcinomas , fusing their spleen cells with ns-1 myeloma cells and selecting for antibodies that bound to mouse bladder carcinomas . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
156,
166
]
} |
immunoblot analysis of total nuclear proteins with the two antibodies demonstrated that protein ba and the major sm antigen have similar molecular weights , but are antigenically distinct . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
29,
45
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} |
both the 8- and 16-day embryo fibroblasts were found to contain hyaluronic acid ( ha ) , dermatan sulfate ( ds ) , heparan sulfate ( hs ) and chondroitin sulfates ( cs ) , the latter being the major component in 8- and 16-day cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
226,
231
]
} |
the blood of colchicine-treated rats possessed no resialylating activity toward the ligand even when supplemented with additional alkaloid in vitro . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
13,
23
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
130,
138
]
} |
the relative affinities of epinephrine and norepinephrine indicated that beta-adrenergic receptors in both preparations are of the beta 2 subtype . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
43,
57
]
} |
instead , the mechanistic basis for the action of dextran-40 would appear to be related to its colloid osmotic properties and its ability to prevent lenticular swelling , which otherwise occurs in the absence of dextran under these experimental conditions . | NA | {
"id": "C0011793",
"name": "dextran-40",
"pos": [
50,
60
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
212,
219
]
} |
the content of alpha neoprotein vs. alpha crystallin was estimated separately on the crystallin , cryoprotein and albuminoid fractions in lenses of animals of different species and ages , in lenses with experimentally induced cataracts and in human cataractous lenses . | NA | {
"id": "C0002257",
"name": "alpha crystallin",
"pos": [
36,
52
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
85,
95
]
} |
the amount of lens proteins bound to the latter immunoadsorbent gave a measure of molecules formed by an association of a with b chains other than in alpha crystallin , that is of alpha neoproteins . | NA | {
"id": "C0010422",
"name": "lens",
"pos": [
14,
18
]
} | {
"id": "C0002257",
"name": "alpha crystallin",
"pos": [
150,
166
]
} |
among the synthetic glycopeptides inducing the production of d factor , murabutide ( mdp [ gln ] -onbu ) was as effective as mdp , although it did not stimulate monocytes to simultaneously release endogenous pyrogen . | NA | {
"id": "C0017953",
"name": "glycopeptides",
"pos": [
20,
33
]
} | {
"id": "C0001060",
"name": "mdp",
"pos": [
125,
128
]
} |
the degree of prevention of exercise-induced asthma by three pharmacological forms of sodium cromoglycate ( scg with lactose powder , scg in micropellets without lactose and scg solution ) was evaluated . | NA | {
"id": "C0978081",
"name": "lactose powder",
"pos": [
117,
131
]
} | {
"id": "C0022949",
"name": "lactose",
"pos": [
162,
169
]
} |
bronchial responsiveness to inhaled histamine was measured before and after ingestion of 40 ml of ice or water at room temperature . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
98,
101
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
105,
110
]
} |
the ultrastructural localization of gold in the ovary of rats injected intraperitoneally with sodium aurothiomalate has been demonstrated using a histochemical technique that visualizes minute traces of gold . | NA | {
"id": "C0018034",
"name": "sodium aurothiomalate",
"pos": [
94,
115
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
203,
207
]
} |
nine furothiocoumarins corresponding to psoralen , 8-methylpsoralen , 3-carbethoxy-8-methylpsoralen , 8-methoxypsoralen , pseudopsoralen , angelicin , isopseudopsoralen , allopsoralen and pseudoisopsoralen were synthesized by treating furocoumarins with phosphorus pentasulfide . | NA | {
"id": "C0016072",
"name": "psoralen",
"pos": [
40,
48
]
} | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
235,
248
]
} |
nine furothiocoumarins corresponding to psoralen , 8-methylpsoralen , 3-carbethoxy-8-methylpsoralen , 8-methoxypsoralen , pseudopsoralen , angelicin , isopseudopsoralen , allopsoralen and pseudoisopsoralen were synthesized by treating furocoumarins with phosphorus pentasulfide . | NA | {
"id": "C0025684",
"name": "8-methoxypsoralen",
"pos": [
102,
119
]
} | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
235,
248
]
} |
several aryldiazonium salts are described as irreversible blockers of the phencyclidine binding site of the nicotinic cholinergic receptor . | NA | {
"id": "C0034830",
"name": "binding site",
"pos": [
88,
100
]
} | {
"id": "C0034792",
"name": "cholinergic receptor",
"pos": [
118,
138
]
} |
when the interspecies cross-reactivity was examined using dna-binding proteins from 6 different sources , 1f4 reacted with the 120- and 32-kda protein bands in hela cells , mouse testis and chicken liver as in the case of calf thymus . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
58,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
143,
150
]
} |
the enzyme was activated in a dose-dependent manner by gtp and by its non-hydrolysable analogue , gtp [ gamma s ] . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
55,
58
]
} | {
"id": "C0079469",
"name": "gtp [ gamma s",
"pos": [
98,
111
]
} |
disulfide-bonded forms of collagen vi were analyzed by immunoblotting of fibroblast culture medium and cell extracts . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
73,
83
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
103,
107
]
} |
sulfotransferase activities towards endogenous serum glycosaminoglycans and exogenously added chondroitin were determined for fetal , newborn and adult bovine sera . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
53,
71
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
94,
105
]
} |
the insulin disulfide reducing thioredoxin system from e. coli was used to investigate a possible mechanism of degradation for the two somatomedins , insulin-like growth factor i and ii ( igf-i and -ii ) . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
135,
147
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
188,
193
]
} |
in contrast , purified phospholipids or a phospholipid fraction from soybean failed to produce an active system . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
23,
36
]
} | {
"id": "C0771648",
"name": "phospholipid fraction",
"pos": [
42,
63
]
} |
as hepatic lipogenesis is depressed during the suckling period , [ malonyl-coa ] is low and entry of long-chain acyl-coa into the mitochondria for partial oxidation to ketone bodies is not restrained . | NA | {
"id": "C0024645",
"name": "malonyl-coa",
"pos": [
67,
78
]
} | {
"id": "C0001374",
"name": "long-chain acyl-coa",
"pos": [
101,
120
]
} |
oligospermia , asthenospermia , teratospermia , and autoimmunity are among the many forms of male infertility which can now be successfully treated by in vitro fertilization . | NA | {
"id": "C0028960",
"name": "oligospermia",
"pos": [
0,
12
]
} | {
"id": "C0021364",
"name": "male infertility",
"pos": [
93,
109
]
} |
oligospermia , asthenospermia , teratospermia , and autoimmunity are among the many forms of male infertility which can now be successfully treated by in vitro fertilization . | NA | {
"id": "C0403823",
"name": "asthenospermia",
"pos": [
15,
29
]
} | {
"id": "C0021364",
"name": "male infertility",
"pos": [
93,
109
]
} |
frequencies of organ-specific antibodies ( antigastric parietal cell , antithyroglobulin , and antithyroid microsome ) in 57 men with genital tract obstructions and positive sit were similar to those for control subjects , and there were no significant differences in the frequencies of non-organ-specific autoantibodies... | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
306,
320
]
} | {
"id": "C0003243",
"name": "antinuclear",
"pos": [
323,
334
]
} |
frequencies of organ-specific antibodies ( antigastric parietal cell , antithyroglobulin , and antithyroid microsome ) in 57 men with genital tract obstructions and positive sit were similar to those for control subjects , and there were no significant differences in the frequencies of non-organ-specific autoantibodies... | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
306,
320
]
} | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
346,
363
]
} |
glycemic control was assessed by means of mean blood glucose ( mbg ) +/- standard deviation ( sd ) , urinary glucose excretion and glycosylated hemoglobin , while renal function was assessed by albumin , igg and beta-2-microglobulin urinary excretion rates , serum creatinine and creatinine clearance . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
47,
60
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
109,
116
]
} |
therefore , not all cell lines derived from hcl patients may be considered as representative of the patients leukemia cells . | NA | {
"id": "C0023443",
"name": "hcl",
"pos": [
44,
47
]
} | {
"id": "C0023418",
"name": "cells",
"pos": [
118,
123
]
} |
acth causes an increase in the synthesis of both the mitochondrial and the microsomal forms of cytochrome p-450 involved in steroid hormone biosynthesis , as well as of the iron-sulfur protein involved in transferring electrons to the mitochondrial forms of cytochrome p-450 , namely , adrenodoxin . | NA | {
"id": "C0022095",
"name": "iron-sulfur protein",
"pos": [
173,
192
]
} | {
"id": "C0001657",
"name": "adrenodoxin",
"pos": [
286,
297
]
} |
whereas the mitochondrial proteins are synthesized as precursors of higher molecular weight which are processed upon insertion into the mitochondria , the microsomal proteins are synthesized as species identical in molecular weight to the mature forms . | NA | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
12,
34
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
166,
174
]
} |
perfusion of glucose into the ileum enhanced the active uptake of the poorly metabolized hexose , galactose , from the jejunum . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
13,
20
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
89,
95
]
} |
perfusion of glucose into the ileum enhanced the active uptake of the poorly metabolized hexose , galactose , from the jejunum . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
89,
95
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
98,
107
]
} |
morphologically , there were two different tissue types ( neurogenous and carcinoid-like ) with numerous cells and nerve fibers reacting immunohistochemically with somatostatin and neurotensin antisera : some immunoreactivity to pp-antibodies was observed . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
193,
201
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
232,
242
]
} |
in a study of 23 matched pairs of type 1 ( insulin-dependent ) diabetic patients receiving continuous subcutaneous insulin infusion or conventional insulin injection therapy respectively , there were no significant differences in serum levels of the acute phase proteins , serum amyloid a and c-reactive protein . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
250,
270
]
} | {
"id": "C0002723",
"name": "serum amyloid a",
"pos": [
273,
288
]
} |
in a study of 23 matched pairs of type 1 ( insulin-dependent ) diabetic patients receiving continuous subcutaneous insulin infusion or conventional insulin injection therapy respectively , there were no significant differences in serum levels of the acute phase proteins , serum amyloid a and c-reactive protein . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
250,
270
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
293,
311
]
} |
these results indicate that hyperinsulinaemia of the magnitude observed in insulin resistant states , such as obesity , can produce insulin resistance in man . | NA | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
28,
45
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
132,
150
]
} |
simultaneous presence of anti-vca ebv igm , early antigen igg antibodies and nuclear antigen antibodies in 7 patients with acute hepatitis associated with anti-hav igm suggests reactivation of ebv or reactivation of clones secreting antibodies anti-ebv in hav infections . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
50,
57
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
77,
92
]
} |
100 formalin with mucosal tissue damaged by episodes of cholangitis could result in sclerosing cholangitis . | NA | {
"id": "C0008311",
"name": "cholangitis",
"pos": [
56,
67
]
} | {
"id": "C0008313",
"name": "sclerosing cholangitis",
"pos": [
84,
106
]
} |
this study presents a model of acute necrotizing pancreatitis in which the severity of the induced pancreatitis ranges dose-dependently from mild interstitial inflammation to severe necrosis . | NA | {
"id": "C0267941",
"name": "acute necrotizing pancreatitis",
"pos": [
31,
61
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
99,
111
]
} |
comparative effects of homoplastic pituitary pars distalis homogenate ( pdh ) , pregnant mare serum gonadotrophin ( pmsg ) , human chorionic gonadotrophin ( hcg ) , growth hormone ( gh ) , pmsg + gh , and hcg + gh on oocyte recruitment and development in the long-term hypophysectomized frog , rana cyanophlyctis ( schn ... | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
182,
184
]
} | {
"id": "C0169964",
"name": "hcg",
"pos": [
205,
208
]
} |
the salmon liver estrogen receptor system has many features in common with typical estradiol receptors from other vertebrates . | NA | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
17,
34
]
} | {
"id": "C0034803",
"name": "estradiol receptors",
"pos": [
83,
102
]
} |
fat bodies did not show an in vitro , hypertrehalosemic response to insulin , glucagon , proctolin , dopamine , epinephrine , norepinephrine , serotonin , octopamine , or tyramine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
112,
123
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
126,
140
]
} |
the main findings were ( 1 ) germinal vesicle breakdown commenced on day 8 under the influence of gth , ( 2 ) after an induction period of about 2 days there was a dramatic and continuing release of 17 alpha 20 beta p in the presence of gth , ( 3 ) gth promoted a moderate release of 17 alpha-hydroxyprogesterone , ( 4 )... | NA | {
"id": "C0020387",
"name": "alpha-hydroxyprogesterone",
"pos": [
287,
312
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
579,
591
]
} |
neurohypophyseal hormones as evolutionary tracers : identification of oxytocin , lysine vasopressin , and arginine vasopressin in two south american opossums ( didelphis marsupialis and philander opossum ) . | NA | {
"id": "C0032017",
"name": "neurohypophyseal hormones",
"pos": [
0,
25
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
70,
78
]
} |
despite the topical action of colloidal bismuth subcitrate in promoting the healing of peptic ulcers , slight absorption of bismuth from the gastrointestinal tract has been reported in colloidal bismuth subcitrate-treated animals and man . | NA | {
"id": "C0005642",
"name": "bismuth",
"pos": [
40,
47
]
} | {
"id": "C0106556",
"name": "colloidal bismuth subcitrate",
"pos": [
185,
213
]
} |
the uptake and subcellular distribution of bismuth by the gastrointestinal tract of rats after 24 hours of colloidal bismuth subcitrate administration was studied . | NA | {
"id": "C0005642",
"name": "bismuth",
"pos": [
43,
50
]
} | {
"id": "C0106556",
"name": "colloidal bismuth subcitrate",
"pos": [
107,
135
]
} |
this high level of false positive diagnosis indicates the frequency of pancreatitis like lesions in the main duct and its side branches in patients without chronic pancreatitis . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
71,
83
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
156,
176
]
} |
in conclusion , lipoprotein abnormalities in pbc patients were characterized by increased levels of apoprotein e and appearance of an abnormal lipoprotein of slow alpha-mobility in addition to well-known lipoprotein x . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
16,
27
]
} | {
"id": "C0023819",
"name": "lipoprotein x",
"pos": [
204,
217
]
} |
three of seven cases contained cells reactive for acth and corticotropin-like intermediate lobe peptide clip or their precursor , pro-opiomelanocortin . | NA | {
"id": "C0056374",
"name": "corticotropin-like intermediate lobe",
"pos": [
59,
95
]
} | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
130,
150
]
} |
a first trimester prenatal diagnosis of adrenoleukodystrophy has been done on chorionic villi biopsy in the pregnancy of a carrier woman . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
2,
17
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
108,
117
]
} |
antibody to lyt-2 blocked antigen-induced ifn-gamma release by all tc clones studied , whilst two monoclonal antibodies to lfa-1 had little or no effect . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
98,
119
]
} |
we have utilized the antigen-binding function of a subset of t8+ cells to remove these cells in vitro from human peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
65,
70
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
113,
147
]
} |
our monoclonal antibodies identify six distinct patterns of epithelial cell antigen expression within the thymus : pan epithelial ( antibody ip1 ) ; | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} |
a three-dimensional model of human renin has been constructed based on the assumption that the overall folding of the aspartyl proteases is very similar . | NA | {
"id": "C0035094",
"name": "renin",
"pos": [
35,
40
]
} | {
"id": "C0078989",
"name": "aspartyl proteases",
"pos": [
118,
136
]
} |
these concentrations of epinephrine had no effect on the basal perfusion pressure of the kidney or on the amplitude of vasoconstrictor responses evoked by exogenous norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
165,
179
]
} |
the effects of endogenous epinephrine ( e ) , released by glucagon injection , and exogenously infused e on plasma norepinephrine ( ne ) and cardiovascular responses before and after beta-blockade were studied in patients with essential hypertension and in age-matched normotensive controls . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
115,
129
]
} |
no significant difference in the synthesis of cortisol , corticosterone , progesterone , 17-hydroxyprogesterone ( 17-ohp ) , and delta-4-androstenedione ( d4 ) was observed between the two groups . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
74,
86
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
89,
111
]
} |
in conscious and anesthetized rats , intravenous doses of angiotensin ii ( 75 and 150 ng/kg ) , norepinephrine ( 0.6 and 1.2 microgram/kg ) , and epinephrine ( 0.6 and 1.2 microgram/kg ) caused dose-dependent increases in arterial pressure and renal and mesenteric vascular resistance . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
96,
110
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
146,
157
]
} |
although there was no statistically significant difference in the measured intracellular total k+ levels between the two groups , on the basis of equilibrium distribution of 86rb+ , we calculated a significantly lower ( p less than 0.001 ) level of exchangeable intracellular k+ in fibroblasts of shr ( 98.2 +/- 1.2 meq/... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
282,
293
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
341,
346
]
} |
immediately after birth , the concentration of alpha 2-macroglobulin is about 200 times higher , that of major acute-phase alpha 1-protein the same , and that of alpha 1-acid glycoprotein , another acute phase protein , is considerably lower , compared with the values observed in healthy adults . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
162,
187
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
198,
217
]
} |
however , the effects of stress on inflammation has not received much attention despite the fact that stress hormones , such as the corticosteroids , are known to reduce inflammation . | NA | {
"id": "C0019932",
"name": "hormones",
"pos": [
109,
117
]
} | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
132,
147
]
} |
we propose that the greater sensitivity of cells to f- at lower medium ph stems from the rapid dissipation of delta ph by the anion . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
41,
42
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
126,
131
]
} |
lambda m5 protein inhibited opsonization of type 5 streptococci by pep m5 antibodies , and antiserum raised against lambda m5 lysates opsonized type 5 streptococci . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
74,
84
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
91,
100
]
} |
each of the five antigenic polypeptides of the recombinant phage m protein also shared epitopes with human heart tissue , as demonstrated by the reactivity of immunoblots of lambda m5 antigens separated on sodium dodecyl sulfate gels with anti-pep m5 antibodies absorbed to and eluted from human heart sarcolemmal membra... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
87,
95
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
184,
192
]
} |
therefore , synthetic lipid a analogs described here were fully immunopharmacologically active in in vitro assays , but all of them were far less active than natural e. coli f515 lipid a regarding the biological activities characteristic of endotoxic lipopolysaccharides and lipid a 's . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
251,
270
]
} | {
"id": "C0023767",
"name": "lipid a 's",
"pos": [
275,
285
]
} |
we show that formaldehyde fixation of salmonella typhimurium lipopolysaccharide ( lps ) to ribosomes purified from brucella abortus induced a primary immunoglobulin m ( igm ) response to lps in c3h/hej mice and upon revaccination resulted in elevated titers of igm and induction of igg antibody to the o antigens of lps ... | NA | {
"id": "C0069180",
"name": "o",
"pos": [
5,
6
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
316,
319
]
} |
we studied the binding of cells of streptococcus pyogenes and mannose-sensitive escherichia coli to human fibroblast cell lines and isolated buccal epithelial cells in relation to the cell-associated endogenous or exogenous fibronectin of the host cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
11,
14
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
106,
116
]
} |
the simultaneous occurrence of the ndv antibodies and h-d antibodies in im and other diseases suggests the possibility that multiple new antigenic determinants , especially those of carbohydrate nature , may appear due to the alteration of self-antigens as a result of various pathologic processes . | NA | {
"id": "C0012634",
"name": "diseases",
"pos": [
85,
93
]
} | {
"id": "C0030660",
"name": "pathologic processes",
"pos": [
277,
297
]
} |
the influence of chemical mutation featuring the selective conversion of asparagine or glutamine to aspartic or glutamic acid , respectively , on the kinetics of refolding of reduced rnase has been studied . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
87,
96
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
112,
125
]
} |
pre-irradiation administration of the radioprotectant drug wr-2721 to rats resulted in a significant reduction in radiation-induced increases in excretion rates of prostaglandins ( pge and pgf2 alpha ) and thromboxane ( txb2 ) . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
164,
178
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
181,
184
]
} |
experiments were carried out with oxygenated solutions of dilute single-stranded phi x174 dna at 10 ( -4 ) m nacl ( large reaction radius of dna ) or at 10 ( -4 ) m nacl + mgcl2 ( small reaction radius ) with t-butanol as a scavenger . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
65,
80
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
141,
144
]
} |
the major lipoxygenase product detected under these conditions in the epithelium was mono-hydroxyeicosatetraenoic acid ( mono-hete ) and in the stroma , 12-hete . | NA | {
"id": "C0020349",
"name": "hydroxyeicosatetraenoic acid",
"pos": [
90,
118
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
153,
160
]
} |
the usefulness of these two mabs in the study of the embryologic development of the retina and of the antigenic epitopes of s-antigen is discussed . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
102,
111
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
112,
120
]
} |
moreover , among those type-specific monoclonal antibodies , 13 of the 18 cav-1 antibodies and 39 of the 77 cav-2 antibodies specifically neutralized only the homologous virus in vitro . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
37,
58
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
114,
124
]
} |
the results obtained have shown that a substantial amount of dermatan sulfate and a relatively small amount of hyaluronic acid , chondroitin , chondroitin sulfate a and/or c were the glycosaminoglycans involved in the connective tissues of the eel skin and that the tissues were devoid of keratan sulfate . | NA | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
61,
77
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
143,
154
]
} |
the results obtained have shown that a substantial amount of dermatan sulfate and a relatively small amount of hyaluronic acid , chondroitin , chondroitin sulfate a and/or c were the glycosaminoglycans involved in the connective tissues of the eel skin and that the tissues were devoid of keratan sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
129,
140
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
183,
201
]
} |
mt-141 , a new cephamycin ( 7 alpha-methoxy-cephalosporin ) antibiotic with a d-cysteine moiety in its 7 beta-side chain , has binding affinities to penicillin-binding proteins of escherichia coli and an inhibitory action on their transpeptidase activity similar to those of other structurally related cephamycins . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
44,
57
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
302,
313
]
} |
most active were ceftriaxone , ceftizoxime and cefotaxime ( mic90 less than or equal to 0.02 mg/l ) ; | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
17,
28
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
47,
57
]
} |
most active were ceftriaxone , ceftizoxime and cefotaxime ( mic90 less than or equal to 0.02 mg/l ) ; | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
31,
42
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
47,
57
]
} |
other compounds which have been used in therapy of bovine mastitis including novobiocin , penicillin g , ampicillin , cloxacillin and rifamycin-sv were used as reference antibiotics . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
90,
102
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
105,
115
]
} |
depending upon the route of administration , this novel lincosaminide was 15 to 95-fold more effective than clindamycin , three- to six-fold better than lincomycin , two- to ten-fold more effective than novobiocin , 13- to 17-times more effective than cloxacillin and 8- to 22-times better than rifamycin-sv on a weight-... | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
108,
119
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
153,
163
]
} |
penicillin g and ampicillin were the least effective drugs tested against mastitis induced by the beta-lactamase producing strain of staph . aureus used in these assays . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
0,
12
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
17,
27
]
} |
pharmacokinetic experiments suggested that the greater effectiveness of pirlimycin compared to clindamycin and lincomycin was due to increased affinity for and prolonged retention in the mammary gland . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
95,
106
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
111,
121
]
} |
a 'continuous culture ' model was no better than conventional susceptibility tests in predicting response of patients with acute uncomplicated urinary infections to amoxicillin , but gave a good correlation with a mouse infection protection test for synergy studies with mecillinam and ampicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
165,
176
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
286,
296
]
} |
this paper presents the mathematical background and the technical components of an in-vitro model that allows the simultaneous simulation of first order elimination kinetics of two drugs with different half-lives . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
165,
173
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
202,
212
]
} |
simultaneous first order elimination kinetics of two drugs with different half-lives were simulated to study antibacterial effects of drug combinations . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
37,
45
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
74,
84
]
} |
strains of escherichia coli , pseudomonas aeruginosa , staphylococcus aureus , and streptococcus pyogenes were exposed to amoxicillin , ampicillin , benzylpenicillin , carbenicillin , cefazolin , chloramphenicol , flucloxacillin , gentamicin , or oxytetracyclin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
122,
133
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
136,
146
]
} |
strains of escherichia coli , pseudomonas aeruginosa , staphylococcus aureus , and streptococcus pyogenes were exposed to amoxicillin , ampicillin , benzylpenicillin , carbenicillin , cefazolin , chloramphenicol , flucloxacillin , gentamicin , or oxytetracyclin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
136,
146
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
149,
165
]
} |
strains of escherichia coli , pseudomonas aeruginosa , staphylococcus aureus , and streptococcus pyogenes were exposed to amoxicillin , ampicillin , benzylpenicillin , carbenicillin , cefazolin , chloramphenicol , flucloxacillin , gentamicin , or oxytetracyclin . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
149,
165
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
168,
181
]
} |
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