text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these findings confirm that the proliferating cells in carotid body hyperplasia are both sustentacular and schwann 's cells , not fibroblasts , and suggest that these cells develop to support an increased number of nerve axons . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
130,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
covariance analysis of the regression of the five true acute-phase hepatic proteins on c-reactive protein showed that , when sepsis occurred after major traumatic injury , the c-reactive protein rise was associated with a significant reprioritization of hepatic acute-phase plasma protein release . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
55,
66
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
176,
194
]
} |
analysis of current data indicates that one of the important and unsolved problems in the concept of sudden cardiac death is the question on the trigger mechanisms of the ventricular fibrillation which is the most frequent cause of heart failure in the sudden death of patients with coronary heart disease . | NA | {
"id": "C0085298",
"name": "sudden cardiac death",
"pos": [
101,
121
]
} | {
"id": "C0011071",
"name": "sudden death",
"pos": [
253,
265
]
} |
these cases were remarkable for unilateral facial nevi , cognitive impairment , seizures , and focal or lateralized epileptic eeg abnormalities . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
80,
88
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
116,
125
]
} |
a single intravenous ( iv ) injection of endotoxin ( bacterial lipopolysaccharide [ lps ] ) produced a mild acute iridocyclitis . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
41,
50
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
63,
81
]
} |
extratympanic electrocochleography ( ecochg ) was performed on 55 consecutive patients ( 110 ears ) suspected of having md-elh , and the results compared with the clinical symptoms of the patients on the day of recording . | NA | {
"id": "C0025281",
"name": "md-elh",
"pos": [
120,
126
]
} | {
"id": "C0206586",
"name": "md-elh",
"pos": [
120,
126
]
} |
differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
102,
107
]
} |
based on results of electrophoresis and radioimmunoassay , we have concluded that these two fractions represent apo b-48 and apo b-100 lipoproteins that we have named apo b-48 and apo b-100 vldl . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
135,
147
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
190,
194
]
} |
frequency-specific electric response audiometry can be performed on difficult to test young children if the child is sedated and proper choices are made of acoustic stimuli and recording parameters , although certain compromises are necessary . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
86,
100
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
108,
113
]
} |
the location of intestinal cells taken from the base of the crypt to the tip of the villus responsive to calcitriol ( 1,25-dihydroxycholecalciferol ) and the distribution of [ 3h ] calcitriol within the intestinal epithelium has been determined in vitamin d-deficient rats . | NA | {
"id": "C0012328",
"name": "dihydroxycholecalciferol",
"pos": [
123,
147
]
} | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
181,
191
]
} |
the preparation , crystallization and low-resolution structure determination of beta-lactamase ( ec 3.5.2.6 , 'penicillinase ' ) from staphylococcus aureus is described . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
80,
94
]
} | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
111,
124
]
} |
the seeds of pea ( pisum sativum l. ) contain several proteins in the albumin solubility fraction that are significant components of total cotyledonary protein ( 5-10 % ) and are accumulated in developing seeds concurrently with storage-protein synthesis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
54,
62
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
70,
77
]
} |
activation of muscarinic receptors in rat parotid cells results in breakdown of polyphosphoinositides liberating inositol phosphates , including inositol trisphosphate . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
113,
132
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
145,
153
]
} |
our earlier binding studies of the 22000- and 20000-mr variants of human growth hormone ( somatotropin ) to pregnant-rabbit liver and mammary receptors [ closset , smal , gomez & hennen ( 1983 ) biochem . j . 214 , 885-892 ] suggested that the 20000-mr variant was a lower-affinity analogue of the 22000-mr molecule . | NA | {
"id": "C0169964",
"name": "human growth",
"pos": [
67,
79
]
} | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
90,
102
]
} |
both hormone variants have essentially the same binding characteristics : slow association ( equilibrium reached in 8-10h at 30 degrees c ) , poor reversibility ( 'tight binding ' ) , linear scatchard plot , same specificity as shown by lack of competition by bovine , porcine or equine growth hormones or human growth h... | NA | {
"id": "C0037663",
"name": "growth",
"pos": [
287,
293
]
} | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
306,
326
]
} |
beta-lactamases , enzymes that catalyse the hydrolysis of the beta-lactam ring in beta-lactam antibiotics , are divided into three classes , a , b and c , on the basis of the structures so far determined . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
0,
11
]
} | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
82,
105
]
} |
the guanine nucleotide gtp in the concentration range between 10 ( -7 ) and 10 ( -3 ) m reduces the labelling of the major mr 51 000 protein and that of the minor mr 89 000 protein , but with a slightly higher potency . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
4,
22
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
23,
26
]
} |
the decrease occurred without increases in hepatic oxidized glutathione ( gssg ) or in the gsh/gssg ratio . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
91,
94
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
95,
99
]
} |
we have found that collagens and/or procollagens , corresponding to genetic types i , iii and iv ( and possibly v ) , are produced and secreted by g8-1 myoblasts . | NA | {
"id": "C0009325",
"name": "collagens",
"pos": [
19,
28
]
} | {
"id": "C0033235",
"name": "procollagens",
"pos": [
36,
48
]
} |
macromolecules released during the cell-enlargement period of synchronously growing cultures in the presence of [ 3h ] proline contained radioactively-labelled hydroxyproline in addition to proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
160,
174
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
190,
197
]
} |
these results show that , during cell-wall growth , specific protein components are released into the culture medium and that at least one of these components contains large amounts of proline and hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
185,
192
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
197,
211
]
} |
when radiolabelled high-density lipoprotein was infused intravenously , the radioactive cholesteryl ester behaved in vivo indistinguishably from endogenous cholesteryl esters produced by the lecithin ( phosphatidylcholine ) : cholesterol acyltransferase reaction . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
191,
199
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
202,
221
]
} |
human peripheral lymphocytes were found to contain at least two distinct aminopeptidases , designated cytosol aminopeptidase and microsomal aminopeptidase , which differed from one another with respect to intracellular localization , substrate specificity , metal-ion activation , km value and electrophoretic mobility . | NA | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
73,
88
]
} | {
"id": "C0023402",
"name": "cytosol aminopeptidase",
"pos": [
102,
124
]
} |
human peripheral lymphocytes were found to contain at least two distinct aminopeptidases , designated cytosol aminopeptidase and microsomal aminopeptidase , which differed from one another with respect to intracellular localization , substrate specificity , metal-ion activation , km value and electrophoretic mobility . | NA | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
73,
88
]
} | {
"id": "C0054943",
"name": "microsomal",
"pos": [
129,
139
]
} |
after intravenous injection into rats , alpha 1-macroglobulin was cleared from plasma with first-order kinetics , showing a half-life of about 9 h , whereas complexes of alpha 1-macroglobulin and subtilisin were cleared with half-lives of only 3 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
103,
111
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
225,
235
]
} |
this interpretation assumes not a channelling of these anions against a membrane potential , negative-inside , but a modification of the permeability of these ions through the tonoplast membrane . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
55,
61
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
159,
163
]
} |
the extent of methylation of a gene , i.e . percent of cytosine present as 5-methylcytosine , is correlated with its activity . | NA | {
"id": "C0010843",
"name": "cytosine",
"pos": [
55,
63
]
} | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
75,
91
]
} |
a novel procedure is presented for the rapid quantitative analysis of eye lens gamma-crystallins and beta s-crystallin by ion-exchange high-performance liquid chromatography on synchropak cm300 . | NA | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
79,
96
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
108,
118
]
} |
kinins liberated from rat hmw kininogen by rat urinary and submaxillary kallikreins were identified to be bradykinin , not arginyl-bradykinin . | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
0,
6
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
131,
141
]
} |
the protein consists of a single polypeptide chain of 121 amino acid residues with serine as the amino-terminal and alanine as the carboxy-terminal residue . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
58,
68
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
116,
123
]
} |
it is suggested that rather the beta-endorphin distribution than the endopeptidase is restricting for gamma-endorphin production in certain brain parts . | NA | {
"id": "C0014242",
"name": "endorphin",
"pos": [
37,
46
]
} | {
"id": "C0061041",
"name": "gamma-endorphin",
"pos": [
102,
117
]
} |
green seedlings of soy bean and wheat contain , like the plant seeds , multiple thioredoxin proteins which possess all typical thioredoxin properties but are inactive in the stimulation assay with spinach fructose-bis-phosphatase . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
92,
100
]
} | {
"id": "C0039938",
"name": "thioredoxin",
"pos": [
127,
138
]
} |
we have measured mitochondrial atp synthesis during passive anion influx and find that influx of phosphate leads to diminished efficiency ( as reflected in the atp:0 ratio ) whereas influx of acetate produced enhanced efficiency . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
60,
65
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
97,
106
]
} |
the mammalian tachykinins substance k , neuromedin k and substance p stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
14,
25
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
26,
37
]
} |
the mammalian tachykinins substance k , neuromedin k and substance p stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
14,
25
]
} | {
"id": "C0027847",
"name": "neuromedin k",
"pos": [
40,
52
]
} |
the mammalian tachykinins substance k , neuromedin k and substance p stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
14,
25
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
57,
68
]
} |
immunofluorescence and immunoblotting experiments , using a monoclonal antibody to the 13 kda mammalian beta-galactoside-binding lectin have shown that human lymphocytes contain nuclear and cytoplasmic proteins of apparent molecular masses of 130 , 80 , 65 and 13 kda that are antigenically related to the lectin and who... | NA | {
"id": "C0607430",
"name": "beta-galactoside-binding lectin",
"pos": [
104,
135
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
306,
312
]
} |
the levels of p21 in hormone-dependent rat tumors was about 7-fold that of hormone-independent tumors . | NA | {
"id": "C0027661",
"name": "hormone-dependent",
"pos": [
21,
38
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
95,
101
]
} |
the dna complex dissociating more slowly than the dna complexes of the anthracyclines , daunorubicin and doxorubicin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
88,
100
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
105,
116
]
} |
[ changes in hdl-cholesterol , subfractions hdl2 and hdl3 and apo-a , apo-a1 and apo-b lipoproteins in patients with chronic renal failure subjected to maintenance hemodialysis ] . | NA | {
"id": "C0003592",
"name": "apo-a",
"pos": [
62,
67
]
} | {
"id": "C0085201",
"name": "apo-a1",
"pos": [
70,
76
]
} |
correlations amongst coumarin 7-hydroxylase , aryl hydrocarbon hydroxylase , 7-ethoxycoumarin o-deethylase and cytochrome p-450 are statistically significant ( r values from 0.56 to 0.73 ) , but do not permit the conclusion , that the same p-450 form catalyzes all the reactions studied . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
46,
74
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin",
"pos": [
77,
93
]
} |
correlations amongst coumarin 7-hydroxylase , aryl hydrocarbon hydroxylase , 7-ethoxycoumarin o-deethylase and cytochrome p-450 are statistically significant ( r values from 0.56 to 0.73 ) , but do not permit the conclusion , that the same p-450 form catalyzes all the reactions studied . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
46,
74
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
111,
127
]
} |
6-mercaptopurine-9-beta-d-ribofuranoside 5'-monophosphate [ mprp ] , bis ( 6-mercaptopurine-9-beta-d-ribofuranoside ) -5 ' , 5 '' '' '-monophosphate [ bis ( mpr ) p ] , bis ( o2 ' , o3'-dibutyryl-6-mercaptopurine-9-beta-d-ribofuranoside ) -5 ' , 5 '' '' '-monophosphate [ bis ( dibut.mpr ) p ] , and o2 ' , o3'-dibutyryl... | NA | {
"id": "C0030054",
"name": "",
"pos": [
0,
0
]
} | {
"id": "C0030106",
"name": "' ,",
"pos": [
303,
306
]
} |
no significant differences between concentrations in the amniotic fluid of the first and second twin were found in respect of conjugated and unconjugated oestrone , oestradiol , oestriol , oestetrol and unconjugated progesterone either before or during labour . | NA | {
"id": "C0014927",
"name": "oestriol",
"pos": [
178,
186
]
} | {
"id": "C0014899",
"name": "oestetrol",
"pos": [
189,
198
]
} |
in the equilibrium between b-dna and z-dna in poly ( dc-dg ) , the [ co ( nh3 ) 6 ] 3+ ion stabilizes the z form 4 orders of magnitude more effectively than the mg2+ ion . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
29,
32
]
} | {
"id": "C0043442",
"name": "z-dna",
"pos": [
37,
42
]
} |
chemical quenching of the samples followed by chromatographic assays for both atp and adp indicates that the enzyme-mn ( ii ) adp-phosphocreatine and the enzyme-mn ( ii ) atp-creatine complexes are present in a ratio of approximately 0.7 to 1 . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
130,
145
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
175,
183
]
} |
addition of the coenzyme pyridoxal 5'-phosphate affects the structural stability , as well as the kinetics of dissociation and deactivation . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
16,
24
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
25,
36
]
} |
as indicated by sodium borohydride reduction , this intermediate is able to interact with the coenzyme pyridoxal 5'-phosphate in the correct way ; | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
94,
102
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
103,
114
]
} |
the rate of exchange of the labile hydrogens of lysozyme was measured by out-exchange of tritium from the protein in solution and from powder samples of varied hydration level , for ph 2 , 3 , 5 , 7 , and 10 at 25 degrees c . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
35,
44
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
89,
96
]
} |
focusing our attention on the effect of the anions on the functional properties of hemoglobin , we measured the bohr effect of untreated hemoglobin in buffers made with hepes [ n- ( 2-hydroxyethyl ) piperazine-n'-2-ethanesulfonic acid ] , mes [ 2- ( n-morpholino ) ethanesulfonic acid ] , and mops [ 3- ( n-morpholino ) ... | NA | {
"id": "C0008203",
"name": "chlorides",
"pos": [
393,
402
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
412,
418
]
} |
when reca protein was preincubated with single-stranded dna in the presence of an atp-regenerating system prior to the addition of homologous duplex dna , a slow presynaptic step was eliminated , and the subsequent homologous pairing was revealed as a reaction whose rate exceeds by 1 or 2 orders of magnitude the calcul... | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
40,
59
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
149,
152
]
} |
this hydrophobic probe labels mostly lipophilin ( the main intrinsic protein of myelin ) and the lipids within the bilayer . | NA | {
"id": "C0060617",
"name": "lipophilin",
"pos": [
37,
47
]
} | {
"id": "C0026972",
"name": "protein",
"pos": [
69,
76
]
} |
axoplasm from freshly isolated myxicola giant axons was mixed with small volumes of 'artificial axoplasm ' containing 45ca and either caegta/egta or cadtpa/dtpa buffers giving various nominal values of [ ca2+ ] . | NA | {
"id": "C0520458",
"name": "cadtpa",
"pos": [
149,
155
]
} | {
"id": "C0013254",
"name": "dtpa",
"pos": [
156,
160
]
} |
a substantial portion of the fluxes of both cations was found to have a specific anion requirement for chloride or bromide , and was not observed when chloride was replaced by nitrate , acetate or methylsulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
81,
86
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
115,
122
]
} |
a substantial portion of the fluxes of both cations was found to have a specific anion requirement for chloride or bromide , and was not observed when chloride was replaced by nitrate , acetate or methylsulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
81,
86
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
151,
159
]
} |
a substantial portion of the fluxes of both cations was found to have a specific anion requirement for chloride or bromide , and was not observed when chloride was replaced by nitrate , acetate or methylsulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
81,
86
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
176,
183
]
} |
the cells were modified by replacement of part of the native phosphatidylcholine with either dipalmitoylphosphatidylcholine , palmitoyloleoylphosphatidylcholine or dilinoleoylphosphatidylcholine catalyzed by phosphatidylcholine-specific transfer protein from bovine liver . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
61,
80
]
} | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
93,
123
]
} |
enhancement of the dipalmitoylphosphatidylcholine content from 7 to 25 % of the total phosphatidylcholine pool increased the rate of [ 3h ] cholesterol efflux , while the addition of the same amount of dilinoleoylphosphatidylcholine slowed it compared to controls . | NA | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
19,
49
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
213,
232
]
} |
the consequences of an increased permeability to ions are : ( a ) alteration of membrane potential , ( b ) net changes in intracellular cations and ( c ) cell swelling , in that order . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
49,
53
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
136,
143
]
} |
freely-diffusing phospholipid spin labels have been employed to study rhodopsin-lipid interactions in frog rod outer segment disc membranes . | NA | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
17,
29
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
80,
85
]
} |
an attempt is made to correlate changes in concentrations of hexose monophosphate , fructose 1,6-bisphosphate and fructose 2,6-bisphosphate with changes in fluxes through 6-phosphofructokinase and fructose-1,6-bisphosphatase in isolated epitrochlearis muscle challenged with insulin and adrenaline . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
61,
67
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
197,
205
]
} |
generation of multiple forms of methionyl-trna synthetase from the multi-enzyme complex of mammalian aminoacyl-trna synthetases by endogenous proteolysis . | NA | {
"id": "C0025653",
"name": "methionyl-trna synthetase",
"pos": [
32,
57
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
101,
127
]
} |
this enzyme catalyzes decarboxylation of malonate in a cyclic manner and produces acetate in proportion to the amount of a given acyl-coa , such as acetyl-coa , malonyl-coa or propionyl-coa . | NA | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
129,
137
]
} | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
148,
158
]
} |
this enzyme catalyzes decarboxylation of malonate in a cyclic manner and produces acetate in proportion to the amount of a given acyl-coa , such as acetyl-coa , malonyl-coa or propionyl-coa . | NA | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
129,
137
]
} | {
"id": "C0024645",
"name": "malonyl-coa",
"pos": [
161,
172
]
} |
based on this result and on studies of colo 205 cell induced tumours where the ganglioside antigen fraction only consisted of a , it is suggested that the c-50 mab defines an antigen determinant present in a . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
91,
98
]
} | {
"id": "C0003316",
"name": "antigen determinant",
"pos": [
175,
194
]
} |
when a cholesterol acceptor ( 10 % fetal bovine serum or 10 mg of lipid-free fetal bovine serum protein ) was added to the culture medium of rabbit mhc cells , the mhc cells retained more than 70 % of their cholesteryl esters after 48 h of incubation . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
7,
18
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
207,
225
]
} |
in contrast , when a cholesterol acceptor ( 10 % fetal bovine serum ) was added to the medium of thioglycollate-induced , cholesterol-enriched macrophages from mice , the mice macrophages retained only 19 % of their cholesteryl esters after 48 h of incubation . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
21,
32
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
216,
234
]
} |
fatty acid composition of stomach acylglycerols at all lactation times was different from that of milk triacylglycerols , containing less medium-chain fatty acids , 8:0 and 10:0 . | NA | {
"id": "C0017860",
"name": "acylglycerols",
"pos": [
34,
47
]
} | {
"id": "C0041004",
"name": "triacylglycerols",
"pos": [
103,
119
]
} |
this preferential hydrolysis was also shown by higher concentrations of medium-chain fatty acids in the free fatty acid fraction . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
85,
96
]
} | {
"id": "C0015688",
"name": "fatty",
"pos": [
109,
114
]
} |
no significant differences were observed in the serum concentrations of protein , cholesterol , cholesteryl esters , phospholipids and apolipoproteins a-i , a-iv and e between leupeptin-treated rats and control animals . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
82,
93
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
96,
114
]
} |
111in-labelled bleomycin-containing small unilamellar liposomes with long half-lives accumulated in the liver after injection to a much lesser extent ( e.g. , 26 % ) than similar liposomes ( 55 % of the dose ) exhibiting a shorter half-life . | NA | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
42,
63
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
179,
188
]
} |
the differences in the thermal lability of each isozyme were still present in purified preparations , although the purified enzymes appeared to be more thermally stable than their crude counterparts . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
48,
55
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
124,
131
]
} |
these data suggest that the structural heterology of the pulmonary and testicular isozymes may affect the interaction of zinc with the respective enzymes and that zinc may contribute to the structural integrity and thermal stability of angiotensin-converting enzyme in each tissue . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
82,
90
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
146,
153
]
} |
if anionic production of quantum bumps in limulus photoreceptors is mediated by changes in cyclic nucleotides , then the electrophysiological response of limulus photoreceptors to tungstate may indicate a role for phosphodiesterase rather than adenylate cyclase in mediating light-induced cyclic nucleotide alterations i... | NA | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
91,
109
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
296,
306
]
} |
based on the reciprocal comparison of prosomatocrinin with proglucagon and pro ( phm-vip ) , it was assumed that the c-terminal fragment of prosomatocrinin separated from somatocrinin by a single arginine residue is a second glucagon-like peptide in the precursor molecule , which apparently possesses a biological activ... | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
59,
70
]
} | {
"id": "C0014361",
"name": "glucagon-like peptide",
"pos": [
225,
246
]
} |
the formation of these defects is modulated by including small amounts of lyso-l-palmitoyl phosphatidylcholine in the dmpc-supported bilayers . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
91,
110
]
} | {
"id": "C0012456",
"name": "dmpc",
"pos": [
118,
122
]
} |
most residues appear to be distributed as a function of the distance from the protein-water interface in a manner consistent with partition energies calculated from partitioning of amino acids between water and octanol phases and from solubilities of amino acids in water , ethanol , and methanol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
274,
281
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
288,
296
]
} |
the preferential interactions of lysozyme with solvent components and the effects of solvent additives on its stability were examined for several neutral osmolytes : l-proline , l-serine , gamma-aminobutyric acid , sarcosine , taurine , alpha-alanine , beta-alanine , glycine , betaine , and trimethylamine n-oxide . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
243,
250
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
253,
265
]
} |
they most likely belong to the t cell lineage , since they express il2 receptors as recognized by the tac antibody and did not bind monoclonal antibodies directed against monocytes or granulocytes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
106,
114
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
132,
153
]
} |
the serratia protease-pretreated platelets did show the lag before thrombin-induced dense granule secretion , characteristic of platelets modified by pretreatment with other nonstimulating proteases . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
13,
21
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
189,
198
]
} |
hematopoietic stem cell toxicity of the murine monoclonal antibody 7.2 , recognizing ia-like antigens on canine cells , was tested in an autologous bone marrow transplantation model . | NA | {
"id": "C0018956",
"name": "hematopoietic stem cell",
"pos": [
0,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
112,
117
]
} |
we found that hemin added to reticulocytes in vitro inhibits not only the total cell incorporation of 59fe from transferrin but also the incorporation of [ 2-14c ] -glycine and transferrin-bound 59fe into heme . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
14,
19
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
205,
209
]
} |
in addition , hemin in concentrations that inhibit the utilization of transferrin-bound iron for heme synthesis has no effect on the incorporation of iron from fe-pbh into heme . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
14,
19
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
172,
176
]
} |
antisera were raised by immunizing rabbits with cloned lines of murine hemopoietic progenitor cells ( p cells ) that depended on the presence of a specific hemopoietic growth factor , persisting cell-stimulating factor ( psf ) , for their growth and survival . | NA | {
"id": "C0018956",
"name": "hemopoietic progenitor cells",
"pos": [
71,
99
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
195,
199
]
} |
carbodiimide-treated heparan sulfate exhibited 10 % to 20 % cross-reactivity compared with a similarly treated heparin , whereas there was no cross-reactivity with five other carbodiimide-treated mucopolysaccharides . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
21,
36
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
196,
215
]
} |
carbodiimide-treated heparan sulfate exhibited 10 % to 20 % cross-reactivity compared with a similarly treated heparin , whereas there was no cross-reactivity with five other carbodiimide-treated mucopolysaccharides . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
111,
118
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
196,
215
]
} |
3h-1-ethyl-3- ( 3-trimethylammoniumpropyl ) carbodiimide iodide was used to demonstrate that carbodiimide forms a stable adduct with heparin and other mucopolysaccharides . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
133,
140
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
151,
170
]
} |
except for heparan sulfate , the addition of radiolabeled carbodiimide to other mucopolysaccharides did not result in epitope formation . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
11,
26
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
80,
99
]
} |
mo5 is borne by the malignant cells of 74 % of patients ( n = 27 ) with acute monocytic leukemia ( french-american-british [ fab ] group m4 , m5 ) , and 50 % of patients ( n = 38 ) with acute granulocytic leukemia ( fab m1 , m2 , and m3 ) . | NA | {
"id": "C0023465",
"name": "acute monocytic leukemia",
"pos": [
72,
96
]
} | {
"id": "C0023467",
"name": "acute granulocytic leukemia",
"pos": [
186,
213
]
} |
in the injured aortae the dry weight and the total amounts of hexosamine , hyaluronic acid , chondroitin-4,6-sulphate , dermatan sulphate , heparan sulphate , and hydroxyproline were increased . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
93,
104
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
120,
137
]
} |
of the coagulation factors ( factors ii , vii and x ) only a modest , but not statistically significant , increase in factor vii and factor x was noted . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
7,
26
]
} | {
"id": "C0033706",
"name": "factors ii",
"pos": [
29,
39
]
} |
of the coagulation factors ( factors ii , vii and x ) only a modest , but not statistically significant , increase in factor vii and factor x was noted . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
7,
26
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
133,
141
]
} |
pretreatment of guinea-pigs with digoxin-specific fab ( fragment antigen binding ) fragments reduced the cardiotoxicity of intravenously infused digoxin ( the lethal doses in fab-treated and control animals were 1.0 and 0.6 mgkg-1 , respectively ) . | NA | {
"id": "C0700607",
"name": "digoxin-specific",
"pos": [
33,
49
]
} | {
"id": "C0021031",
"name": "fab",
"pos": [
175,
178
]
} |
adenosine 5 ' 0- ( 2-thiotriphosphate ) ( atp beta s ) was more active than adenosine 5 ' 0 ( 1-thiotriphosphate ) ( atp alpha s ) and atp in producing contractile responses on the vas deferens of rat and guinea-pig , and guinea-pig bladder , though the difference of potency was less marked for producing relaxation of ... | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
135,
138
]
} |
the calculated pa2 values for atp , adenosine , beta , gamma-methylene atp ( appcp ) and atp alpha s were similar , suggesting a common site of action . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
36,
45
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
89,
92
]
} |
the angiotensin-converting enzyme inhibitor captopril at 2.2 microm reversibly reduced the ai response to 13.7 +/- 3.2 % ( mean +/- s.e . mean ) of the aii response , which was unaffected . | NA | {
"id": "C0003018",
"name": "ai",
"pos": [
91,
93
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
152,
155
]
} |
saralasin , an aii receptor blocker , at 94 nm reversibly antagonized both ai-and aii-induced increases in foetoplacental perfusion pressure . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
82,
85
]
} |
an investigation of the effects of gamma-aminobutyric acid ( gaba ) and the selective gabab receptor agonist , baclofen , on basal and stimulated adenosine 3':5'-cyclic monophosphate ( cyclic amp ) levels in slices of rat cerebral cortex has been carried out . | NA | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
35,
58
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
111,
119
]
} |
gaba ( in the presence of nipecotic acid ) and baclofen both potentiated the maximal response to noradrenaline with baclofen ( 100 microm ) increasing the level of cyclic amp produced by noradrenaline ( 100 microm ) by 133 % . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
116,
124
]
} |
gaba ( 0.3-100 microm ) was rather less effective than baclofen , increasing the response to noradrenaline by 70 % at 100 microm . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
55,
63
]
} |
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