text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
cold with immobilization or insulin treatment depressed the adrenal adrenaline content and increased the plasma concentrations of noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
130,
143
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
148,
158
]
} |
to investigate the vasodilator actions of nitroglycerine and isoprenaline , the effects of these agents , dibutyryl cyclic amp ( db cyclic amp ) and 8-bromo cyclic gmp ( 8-br cyclic gmp ) on intact muscle tissue , and cyclic amp and cyclic gmp on skinned muscle of the rabbit mesenteric artery were investigated . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
106,
126
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
218,
228
]
} |
cumulative concentration-response curves for adenosine and 2-chloroadenosine were constructed at 37 , 30 or 27 degrees c . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
45,
54
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
59,
76
]
} |
this increase in sensitivity does not arise from inhibition of uptake or deamination by cooling , since it occurs equally for adenosine and 2-chloroadenosine , the latter being immune to these processes . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
126,
135
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
140,
157
]
} |
in contrast , the sensitivity of the trachea was not affected ( 2-chloroadenosine ) or reduced ( adenosine ) by cooling . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
64,
81
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
97,
106
]
} |
ici 118,551 competitively antagonized the effects of fenoterol , isoprenaline , adrenaline and noradrenaline to a similar extent ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
95,
108
]
} |
differential antagonism by bay k 8644 , a dihydropyridine calcium agonist , of the negative inotropic effects of nifedipine , verapamil , diltiazem and manganese ions in canine ventricular muscle . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
42,
57
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
113,
123
]
} |
antagonism between either the dihydropyridine calcium agonist , bay k 8644 , or high external ca2+ and the calcium antagonists , nifedipine , verapamil and diltiazem , and mn2+ was investigated in canine isolated ventricular trabeculae . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
30,
45
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
129,
139
]
} |
this study showed no major difference in efficacy between sodium valproate and phenytoin in adults with recent onset of epilepsy , irrespective of the type of seizures that the patient suffered . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
120,
128
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
159,
167
]
} |
( 1982 ) in the brains of kuru-inoculated monkeys in their early stages before spongiform encephalopathy has become established . | NA | {
"id": "C0022802",
"name": "kuru",
"pos": [
26,
30
]
} | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
79,
104
]
} |
the neuromodulatory role of opioid peptides in the release of neurohypophysial hormones appears to be altered in the shr such that vp release is suppressed and ot release is augmented . | NA | {
"id": "C0032017",
"name": "neurohypophysial",
"pos": [
62,
78
]
} | {
"id": "C0030095",
"name": "ot",
"pos": [
160,
162
]
} |
in saline-pretreated conscious rats dmk-cut caused a marked hypertension , tachycardia and increases in plasma ne , epi and vasopressin . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
7,
9
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
116,
119
]
} |
the serum ast ( aspartate aminotransferase , serumglutamic oxalacetic transaminase [ sgot ] ) was abnormal in 97 % and was higher than the alanine aminotransferase ( alt ) in 93 % of cases compared with 17 % in 100 consecutive cases of chronic active hepatitis . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
16,
42
]
} | {
"id": "C0002594",
"name": "transaminase",
"pos": [
70,
82
]
} |
the serum ast ( aspartate aminotransferase , serumglutamic oxalacetic transaminase [ sgot ] ) was abnormal in 97 % and was higher than the alanine aminotransferase ( alt ) in 93 % of cases compared with 17 % in 100 consecutive cases of chronic active hepatitis . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
70,
82
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
139,
163
]
} |
expression of keratin was found in all the mesotheliomas and adenocarcinomas with antibody ae1 as well as with the rabbit antiserum ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
82,
90
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
122,
131
]
} |
morphologic and immunohistochemical studies highly suggest that both tumors are manifestations of the same neoplastic process . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
69,
75
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
107,
125
]
} |
the patient 's serum ( 185 ng/ml ) and a tumor metastasis ( 720 ng/g ) contained large amounts of immunoactive material that diluted in parallel to cg-beta standard , but neither chorionic gonadotropin ( cg ) , its alpha subunit , nor other placental proteins were detected . | NA | {
"id": "C0018062",
"name": "chorionic gonadotropin",
"pos": [
179,
201
]
} | {
"id": "C0017963",
"name": "alpha subunit",
"pos": [
215,
228
]
} |
when the patient 's serum was chromatographed on a dextran gel , the cg-beta immunoactivity eluted in a position of higher apparent molecular weight than either standard cg or cg-beta , suggesting that this neoplasm secreted an altered molecular form of the cg-beta subunit . | NA | {
"id": "C0018062",
"name": "cg",
"pos": [
69,
71
]
} | {
"id": "C0106132",
"name": "cg-beta subunit",
"pos": [
258,
273
]
} |
when hemibody irradiation is combined with chemotherapy , responses have been shown in metastases for several primaries , particularly small cell carcinoma , which is perhaps the most encouraging , and supports further research in the treatment of micrometastatic disease for this tumor type . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
87,
97
]
} | {
"id": "C1513276",
"name": "micrometastatic",
"pos": [
248,
263
]
} |
in continuation of efforts to correlate the antitemplate activities of modified polynucleotides with their structure , and to understand the factors governing both their potency and stability , a group of single-stranded poly ( ribo- and deoxyribo- ) nucleotides , and the `` '' hybrid '' '' double-stranded complexes we... | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
80,
95
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
251,
262
]
} |
in a comparative study as inhibitors of the dna polymerase alpha from rat hepatoma , the results showed that the modified polynucleotides were more potent than the unmodified ones , in general , the polydeoxyribonucleotides were better antitemplates than their ribo counterparts and the poly ( a70 , hs5u30 ) .poly ( dt ... | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
122,
137
]
} | {
"id": "C0032468",
"name": "polydeoxyribonucleotides",
"pos": [
199,
223
]
} |
in a comparative study as inhibitors of the dna polymerase alpha from rat hepatoma , the results showed that the modified polynucleotides were more potent than the unmodified ones , in general , the polydeoxyribonucleotides were better antitemplates than their ribo counterparts and the poly ( a70 , hs5u30 ) .poly ( dt ... | NA | {
"id": "C0032468",
"name": "polydeoxyribonucleotides",
"pos": [
199,
223
]
} | {
"id": "C0032416",
"name": "poly ( dt",
"pos": [
310,
319
]
} |
acquired karyotypic changes analyzed by banding techniques in 21 patients with a malignant hematologic disorder and a major constitutional chromosome anomaly , including ten patients with trisomy 21 , five patients with a balanced translocation , and six patients with a sex chromosome anomaly . | NA | {
"id": "C0008626",
"name": "chromosome anomaly",
"pos": [
139,
157
]
} | {
"id": "C0036868",
"name": "sex chromosome anomaly",
"pos": [
271,
293
]
} |
although the different tumor cells displayed a wide range of sensitivity to the pbmc , in each instance , the number of colonies formed by the tumor cells exposed to the pbmc was consistently reduced relative to that of control cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
80,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
228,
233
]
} |
the inhibitory effect on the colony-forming cells was especially pronounced with pbmc preincubated with interleukin-2 and was dependent on the ratio of tumor cells to pbmc in the culture . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
167,
171
]
} |
four folate analogues , methotrexate , aminopterin , 10-deazaminopterin , and 10-ethyl-10-deazaaminopterin were assessed for their ability to be metabolized to poly-gamma-glutamyl derivatives in three tumor lines which vary in their sensitivity to these agents . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
24,
36
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
95,
106
]
} |
in l1210 and sarcoma 180 cells , the relative rates of polyglutamylation were in the order aminopterin greater than 10-ethyl-10-deazaaminopterin greater than methotrexate greater than 10-deazaaminopterin . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
91,
102
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
158,
170
]
} |
in contrast , the relative rates of polyglutamylation in manca cells were in the order 10-ethyl-10-deazaaminopterin approximately equal to aminopterin greater than 10-deazaaminopterin greater than methotrexate , suggesting that folylpolyglutamyl synthetase may have varying substrate preferences in different cell types ... | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
104,
115
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
197,
209
]
} |
monoclonal antibodies against the thy 1.1 differentiation antigen are ineffective in the treatment of transplanted akr t-cell lymphoma once a palpable tumor nodule is present , due to the inability of the host to eliminate antibody-coated tumor cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
223,
231
]
} |
a number of bap : dna adducts were present in the dna from the cultures from all three species after 5 h of bap treatment . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
18,
29
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
50,
53
]
} |
both the prostaglandin h synthase : arachidonic acid and horseradish peroxidase : hydrogen peroxide systems were used to investigate the binding of [ 3h ] -2-af to dna and the nature of the dna adducts formed from peroxidative activation of 2-af . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
164,
167
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
190,
201
]
} |
these results indicate that release of many cellular proteins , including glycoproteins , external surface proteins , and some melanoma-associated antigens , does not require glycosylation . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
53,
61
]
} | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
99,
115
]
} |
when a panel of tumors of the different histological types was tested for its sensitivity to mitozolomide in vitro , in the 6-day subrenal capsule assay in conventional mice , and , in some cases , as s.c. growing tumors in nude mice , good agreement between the different assay systems was seen . | NA | {
"id": "C0027652",
"name": "of tumors",
"pos": [
13,
22
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
214,
220
]
} |
to clarify these questions , we have searched for gene albumin transcripts by in situ hybridization , and for the corresponding protein by immunoperoxidase , on adjacent liver sections . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
55,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
128,
135
]
} |
we observed that all hepatocytes contain albumin transcripts as well as the albumin protein , without any detectable zonal variation within the liver lobule . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} |
to assess the numbers and types of pcna ( proliferating cell nuclear antigen ) species , immunoprecipitation studies on hela cell , nuclear and nucleolar extracts were performed . | NA | {
"id": "C0069115",
"name": "pcna",
"pos": [
35,
39
]
} | {
"id": "C0072108",
"name": "proliferating cell nuclear antigen",
"pos": [
42,
76
]
} |
2-acetylaminofluorene ( aaf ) , 2-aminofluorene ( af ) and n-hydroxy-2-acetylaminofluorene ( n-oh-aaf ) could be activated to mutagens in s. typhimurium using either 9000 g supernatant ( s9 ) or hepatocytes isolated from rats , mice , hamsters or guinea pigs . | NA | {
"id": "C0000248",
"name": "2-acetylaminofluorene",
"pos": [
0,
21
]
} | {
"id": "C0020319",
"name": "n-hydroxy-2-acetylaminofluorene",
"pos": [
59,
90
]
} |
the pressor responses to substance p injected into the lateral brain ventricle were accompanied by marked and short latency increases in heart rate , cardiac output , splanchnic , renal , and adrenal nerve activity , and a rise in plasma noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
238,
251
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
256,
266
]
} |
binding of the dihydropyridine calcium antagonist [ 3h ] nitrendipine was studied in cardiac myocytes incubated in normal and high potassium buffer so that we might examine the voltage dependence of dihydropyridine binding . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
57,
69
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
199,
214
]
} |
from the differences in the slope of the emf vs the amount of bicarbonate added at the two phs we calculated the thermodynamic association constants of the sodium bicarbonate and sodium carbonate complexes ( knahco3 ( 0 ) = 0.53 and knaco3- = 24 ) . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
62,
73
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
156,
174
]
} |
in electrophoretograms of creatine kinase ( ck ; ec 2.7.3.2 ) in patients ' blood , a band , presumably of mitochondrial origin , is occasionally observed on the cathodic side of the ck-mm fraction . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
26,
41
]
} | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
183,
188
]
} |
this assay involves use of three monoclonal antibodies and an antibody-magnetic particle conjugate that rapidly and completely separates bound and free tracer in a magnetic field . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
33,
54
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
62,
70
]
} |
erythrocyte acetylcholinesterase ( ec 3.1.1.7 ) and plasma pseudocholinesterase ( ec 3.1.1.8 ) were determined from the day of admission up to 10 days in patients who have consumed organophosphate or carbamate poisons . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
12,
32
]
} | {
"id": "C0008429",
"name": "plasma pseudocholinesterase",
"pos": [
52,
79
]
} |
beta-galactosidase activity but not beta-glucuronidase , n-acetyl-beta-d-galactosaminidase or arylsulphatase a activity , is known to be significantly lower in cultured human skin fibroblasts from patients with cystinosis than in cells from control subjects . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
180,
191
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
the effects of the long acting met-enkephalin analogue d-ala2-mephe4-met-enkephalin-o-ol ( damme ) and the opiate antagonist naloxone on the plasma catecholamine responses to insulin-induced hypoglycaemia have been investigated in two separate studies . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
31,
45
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
91,
96
]
} |
damme depressed basal noradrenaline and adrenaline at 15 min , and blunted both the noradrenaline and adrenaline responses to hypoglycaemia . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
22,
35
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
despite the rise in t4 serum thyrotrophin ( tsh ) levels were increased , suggesting an effect of amiodarone on the anterior pituitary . | NA | {
"id": "C0040160",
"name": "thyrotrophin",
"pos": [
29,
41
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
116,
134
]
} |
effect of a single bolus of etomidate upon eight major corticosteroid hormones and plasma acth . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
55,
69
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
70,
78
]
} |
in a prospective controlled trial we investigated the effect of an induction dose of etomidate ( 0.26 mg/kg i.v . ) on plasma acth , progesterone , 17 alpha oh-progesterone , 11-deoxycortisol , cortisol , cortisone , corticosterone , 11-deoxycorticosterone , and aldosterone in seven males undergoing general anaesthesia... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
133,
145
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
148,
150
]
} |
in contrast , no significant difference in plasma progesterone and 17 alpha-oh-progesterone levels was found between the two groups indicating that the cholesterol-side-chain cleavage enzyme is less sensitive to etomidate than 11 beta-hydroxylase . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
50,
62
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
67,
69
]
} |
recent evidence has shown that not only aids but also the majority of 'unexplained ' persistent , generalized lymphadenopathy ( pgl ) are related to htlv-iii/lav infections . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
40,
44
]
} | {
"id": "C0019693",
"name": "htlv-iii/lav infections",
"pos": [
149,
172
]
} |
agreement between the presence of skin reactivity and allergen specific iggd titres ranged from one of 14 for cat dander to 22 of 34 for house dust . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
54,
62
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
137,
147
]
} |
we have examined the identity of the t colony progenitor cell ( tcpc ) in t cell depleted peripheral blood mononuclear cells ( pbm-e- ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
17,
20
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
90,
124
]
} |
in contrast , the degree of high density lipoprotein ( hdl ) saturation in cholesterol ( hdl-cholesterol/hdl-phospholipids ) and the classical atherogenous index ( cholesterol/hdl-cholesterol ) were not modified . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
75,
86
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
176,
191
]
} |
trauma , rather than the amount of bone in the forearm , appears to be the main determinant of fracture risk . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
0,
6
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
95,
103
]
} |
further studies will also establish whether the changes in myelination primarily reflect the pathologic processes occurring in the tissues , such as the amount of gliosis , or are a marker of functional involvement . | NA | {
"id": "C0030660",
"name": "pathologic processes",
"pos": [
93,
113
]
} | {
"id": "C0017639",
"name": "gliosis",
"pos": [
163,
170
]
} |
the release of ca is reflected by an increase in concentrations of free norepinephrine and total ( free plus sulfated ) epinephrine 3 minutes and of total dopamine and norepinephrine 10 minutes after the mcp bolus dose , whereas glucagon had an effect on the release of free epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
275,
286
]
} |
regional catheterization before and after mcp dosing in one subject showed a considerable increase in adrenal epinephrine and norepinephrine concentrations 45 seconds after the mcp bolus dose . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
126,
140
]
} |
these results do not provide experimental support for the hypothesis that calcium salts and pigment material found in gallstones , or gallbladder mucin at concentrations less than 10 mg/ml , act as nucleating agents for cholesterol crystal and stone formation . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
118,
128
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
244,
249
]
} |
the in vitro activity of sulphones alone and in combination with ampicillin or amoxicillin against legionella pneumophila and other legionella spp . including beta-lactamase studies . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
65,
75
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
79,
90
]
} |
synergy was commonly observed when the sulphones were combined with ampicillin or amoxicillin , generally reducing the drug minimum inhibitory concentrations ( mics ) fourfold to eightfold ( synergy rates 85-91 % ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
68,
78
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
82,
93
]
} |
employing an elisa inhibition assay , none showed any detectable affinity for bovine collagen types i , ii , iii , or iv , bovine fibronectin or chondroitin or dermatan sulfate glycosaminoglycans . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
145,
156
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
160,
168
]
} |
employing an elisa inhibition assay , none showed any detectable affinity for bovine collagen types i , ii , iii , or iv , bovine fibronectin or chondroitin or dermatan sulfate glycosaminoglycans . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
145,
156
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
177,
195
]
} |
a 5 , 10 and 25 fold increase in luminal l-alanine and l-phenylalanine concentration in na-free choline krebs ringer after preloading with ouabain resulted in increase of amino acid absorption of approximately the same order of magnitude . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
43,
50
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
171,
181
]
} |
the fact that the kidneys excrete dextran means that dextran 70,000 is not a useful marker for calculating the capillary permeability in hamadryas baboons . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
34,
41
]
} | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
53,
63
]
} |
amino acid sequences of immunoglobulins , histocompatibility antigens , thy-1 antigens , polyimmunoglobulin receptor and t-lymphocyte receptor have been compared and conserved residues correlated with features on the atomic models of immunoglobulin fragments . | NA | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
24,
39
]
} | {
"id": "C0021009",
"name": "immunoglobulin fragments",
"pos": [
234,
258
]
} |
among these are ca ions , cyclic nucleotides ( cgmp in particular ) , and phosphate nucleotides ( atp and gtp ) . | NA | {
"id": "C0028631",
"name": "cyclic",
"pos": [
26,
32
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
84,
95
]
} |
the model is consistent with the phase behavior of membrane lipids and the action of cryoprotective agents in modifying lipid phase properties . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
51,
66
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
120,
125
]
} |
proteases identified as exopeptidases including dipeptidyl ii and iii , phenylalanine , leucine , methionine , lysine and alanine aminopeptidases , and prolyl endopeptidase were found in extracts of human fetal lenses . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
0,
9
]
} | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
24,
37
]
} |
endometrial cells in suspension were stained with propidium iodide and a monoclonal antibody against a cytokeratin intermediate filament protein specific for glandular and columnar cells ( rge 53 ) . | NA | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
103,
114
]
} | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
115,
144
]
} |
to determine if malabsorption of zinc contributes to the zinc deficiency found in cirrhosis , the absorption of an oral dose of zncl2 , labeled with 65zn and a nonabsorbed marker 51crcl3 , was determined from the ratio of these isotopes in a stool specimen . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
33,
37
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
128,
133
]
} |
the absorption , distribution , metabolism , and excretion of 14c-benzo ( f ) quinoline ( bq ) , an air pollutant and component of cigarette smoke , was studied in male fischer 344 rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
32,
42
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
49,
58
]
} |
given the rapid metabolism and excretion of this compound it is unlikely that low dose , repeated exposure would result in its accumulation in the body . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
16,
26
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
31,
40
]
} |
the absorption , metabolism , and excretion of quazepam , a new benzodiazepine hypnotic , was investigated in six normal male volunteers after oral administration of 25 mg 14c-quazepam in solution . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
34,
43
]
} |
two of the 31 died , of the remaining 29 with permanent ischaemia 27 still had signs of infarction in the ecg on follow-up , despite successful revascularisation ; | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
56,
65
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
88,
98
]
} |
if after tca there is vascular occlusion with permanent transmural ischaemia , it is usually not possible , even under optimal conditions , to prevent infarction because the ischaemia tolerance of the human myocardium at normothermia will have been exceeded . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
67,
76
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
151,
161
]
} |
the therapeutic doses of cyclophosphamide are shown to inhibit the amino acid incorporation into acid insoluble pool of predominantly leukemic lymphocytes , while chlorbutin and degranol caused the greater suppression of the amino acid incorporation into healthy cells . | NA | {
"id": "C0815040",
"name": "amino acid",
"pos": [
67,
77
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
225,
235
]
} |
evaluation of carbamate toxicity : acute toxicity in a culture of paramecium multimicronucleatum upon exposure to aldicarb , carbaryl , and mexacarbate as measured by warburg respirometry and acute plate assay . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
14,
23
]
} | {
"id": "C0001994",
"name": "aldicarb",
"pos": [
114,
122
]
} |
evaluation of carbamate toxicity : acute toxicity in a culture of paramecium multimicronucleatum upon exposure to aldicarb , carbaryl , and mexacarbate as measured by warburg respirometry and acute plate assay . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
14,
23
]
} | {
"id": "C0036860",
"name": "carbaryl",
"pos": [
125,
133
]
} |
the present study was undertaken to explore the acute toxicity of three carbamate pesticides , aldicarb , carbaryl , and mexacarbate , on a population of paramecium multimicronucleatum . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
72,
81
]
} | {
"id": "C0001994",
"name": "aldicarb",
"pos": [
95,
103
]
} |
the present study was undertaken to explore the acute toxicity of three carbamate pesticides , aldicarb , carbaryl , and mexacarbate , on a population of paramecium multimicronucleatum . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
72,
81
]
} | {
"id": "C0036860",
"name": "carbaryl",
"pos": [
106,
114
]
} |
the serum concentrations of the aminoglycosides neomycin , kanamycin and streptomycin were determined after intravenous ( iv ) and intramuscular ( im ) administration . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
32,
47
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
73,
85
]
} |
the kinetic parameters for net transport of dopamine , epinephrine , norepinephrine , 5-hydroxytryptamine , s alpha-methyldopamine , r alpha-methyldopamine , and 1r,2s alpha-methylnorepinephrine into highly purified bovine chromaffin ghosts were determined using an on-line amperometric technique . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
55,
66
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
180,
194
]
} |
the kinetic parameters for net transport of dopamine , epinephrine , norepinephrine , 5-hydroxytryptamine , s alpha-methyldopamine , r alpha-methyldopamine , and 1r,2s alpha-methylnorepinephrine into highly purified bovine chromaffin ghosts were determined using an on-line amperometric technique . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
69,
83
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
168,
194
]
} |
reactivity of the delta-chain increases after exposure to cholinergic effectors with a half-life slower than the kinetics of receptor activation or rapid desensitization . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
87,
96
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
113,
121
]
} |
these findings indicate that the plasminogen activators secreted by epithelial cells represent a unique and different class of tissue plasminogen activator . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
33,
55
]
} | {
"id": "C0032143",
"name": "tissue plasminogen activator",
"pos": [
127,
155
]
} |
the chemical structure of the k52 antigenic capsular polysaccharide ( k52 antigen ) of escherichia coli o4 : k52 : h- was elucidated by composition , nuclear magnetic resonance spectroscopy , methylation , periodate oxidation before and after graded acid hydrolysis and by oligosaccharide analysis . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
53,
67
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
273,
288
]
} |
bound ligand dissociation from this soluble complex was similar to that from the membranous receptors of origin and the marked increase in the rate of dissociation induced by gtp was preserved in the soluble state , indicating that the solubilized cck receptors remained functionally coupled with the guanine nucleotide ... | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
175,
178
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
301,
319
]
} |
the ca-atpase crystals formed with monovanadate and with decavanadate are similar in appearance , but decavanadate is particularly effective in promoting the crystallization of ca2+-atpase at low v concentration ( 10-100 microm ) in a ca2+-free medium . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
7,
13
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
235,
238
]
} |
using both an agarose gel assay and electron microscopy , we find that the product of the gene uvsx catalyzes the assimilation of a linear single-stranded fd dna fragment into superhelical double-stranded fd dna ( rfi ) . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
139,
154
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
189,
204
]
} |
no differences were detected between flc-1 and alc-1 using three different proteases and amino acid compositions were similar with the exception of glycine content . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
89,
99
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
148,
155
]
} |
in contrast to many other virus-transformed fibroblasts , these cells continued making collagen and fibronectin , and there were no gross morphological changes as observed in the light microscope . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
64,
69
]
} |
mav.2-o-infected fibroblasts and the cloned cells synthesized 2-3 times more collagen type i , the main product of their biosynthetic machinery , than control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
17,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
159,
164
]
} |
the proportion of the total cellular rna consisting of specific mrnas for the precursor of collagen , procollagen pro-alpha 1 and pro-alpha 2 chains , was higher in the infected cells than in normal fibroblasts . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
91,
99
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
102,
113
]
} |
the proportion of the total cellular rna consisting of specific mrnas for the precursor of collagen , procollagen pro-alpha 1 and pro-alpha 2 chains , was higher in the infected cells than in normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
178,
183
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
199,
210
]
} |
hepatectomy and infusion of glucose combined with bcaa sharply reduced the plasma and brain amino acid concentrations of other lnaa . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
50,
54
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
92,
102
]
} |
hepatectomy and infusion of glucose combined with bcaa sharply reduced the plasma and brain amino acid concentrations of other lnaa . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
92,
102
]
} | {
"id": "C0301715",
"name": "amino",
"pos": [
92,
97
]
} |
by using well characterized mouse monoclonal antibodies ( mab ) directed against htgb , it was shown that the fine specificities of induced anti-htgb ab in rabbits , natural ab in normal subjects and autoantibodies in diseased patients were similar ; | NA | {
"id": "C0003241",
"name": "ab",
"pos": [
59,
61
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
200,
214
]
} |
antibodies directed against the t cell receptor-associated antigen t3 served as efficient stimuli , especially if aided by agents that cross-link immunoglobulin , indicating that a triggering signal is received by a t cell via aggregation of its antigen receptor complex . | NA | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
32,
47
]
} | {
"id": "C0034788",
"name": "antigen receptor",
"pos": [
246,
262
]
} |
the alpha-adrenoceptors of the human prostate gland were characterized in vitro by the use of antagonists selective for alpha 1- and alpha 2-adrenoceptor subtypes . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
4,
23
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptor",
"pos": [
133,
153
]
} |
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