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by dna hybridization techniques , we clearly demonstrated human papillomavirus ( hpv-16-related ) sequences in five patients with this neoplasm .
nichd_parent_of
{ "id": "C0021344", "name": "human papillomavirus", "pos": [ 58, 78 ] }
{ "id": "C0999806", "name": "hpv-16", "pos": [ 81, 87 ] }
it is inferred that these two compounds are capable of inactivating intracellular organisms and would therefore be useful for treating or preventing chronic infections caused by pathogens which survive intracellularly .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 82, 91 ] }
{ "id": "C0450254", "name": "pathogens", "pos": [ 178, 187 ] }
persistent infection by the retrovirus caprine arthritis -- encephalitis virus ( caev ) induces arthritis in goats which closely resembles rheumatoid arthritis .
nichd_parent_of
{ "id": "C0003864", "name": "arthritis", "pos": [ 47, 56 ] }
{ "id": "C0003873", "name": "rheumatoid arthritis", "pos": [ 139, 159 ] }
although there were no qualitative differences in the pattern between paraproteins from benign and malignant cases , a distinct quantitative difference was found : paraproteins from myeloma patients had significantly more subfractions extending over a wider ph range than paraproteins from patients with benign monoclona...
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 128, 140 ] }
{ "id": "C1514721", "name": "range", "pos": [ 261, 266 ] }
maternal heart rate was derived from the arterial pressure curve , fetal heart rate from a fetal ecg .
nichd_parent_of
{ "id": "C0018810", "name": "heart rate", "pos": [ 9, 19 ] }
{ "id": "C0018811", "name": "fetal heart", "pos": [ 67, 78 ] }
dystrophic hamster may be related more to multiorgan diseases possibly associated with immunological or other systemic diseases .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 53, 61 ] }
{ "id": "C0442893", "name": "systemic diseases", "pos": [ 110, 127 ] }
small intestinal lengthening by the bianchi procedure has now had successful clinical application in children and neonates with the short-bowel syndrome .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 101, 109 ] }
{ "id": "C0021289", "name": "neonates", "pos": [ 114, 122 ] }
in addition , the quantitative study of an ensemble of isis in the non-stationary state revealed that ft ii units discharged regularly in response to an optimum range of indentation but irregularly to indentation outside this range , although ft i units produced irregular discharges irrespective of the magnitude of ind...
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 18, 30 ] }
{ "id": "C1514721", "name": "range", "pos": [ 226, 231 ] }
rats with no remaining microscopic disease after operation were immunized with one of four tumor isografts .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 35, 42 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 91, 96 ] }
severe coagulation changes could be demonstrated in anll patients with fab type m2 ( myeloblastic leukemia with maturation ) and fab type m5 ( monocytic leukemia ) .
nichd_parent_of
{ "id": "C0023467", "name": "anll", "pos": [ 52, 56 ] }
{ "id": "C0023479", "name": "myeloblastic leukemia", "pos": [ 85, 106 ] }
altered ratios of t lymphocyte subsets have recently been reported in some forms of glomerulonephritis , including membranous glomerulonephritis .
nichd_parent_of
{ "id": "C0017658", "name": "glomerulonephritis", "pos": [ 84, 102 ] }
{ "id": "C0017665", "name": "membranous glomerulonephritis", "pos": [ 115, 144 ] }
at present , some 20 children suffering from different diseases , such as spina bifida , erb 's palsy or a tumour of the cord , perform a daily domiciliary treatment with especially constructed home stimulators .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 55, 63 ] }
{ "id": "C0027651", "name": "tumour", "pos": [ 107, 113 ] }
an explanation of the relationships between mass , metabolic rate and characteristic skeletal length for birds and mammals .
nichd_parent_of
{ "id": "C1521970", "name": "characteristic", "pos": [ 70, 84 ] }
{ "id": "C1444754", "name": "length", "pos": [ 94, 100 ] }
both body mass and metabolic rates are shown to result from a homogeneous vertebrate design quantitatively expressed in terms of a set of nearly invariant parameters with five degrees of freedom : propulsion technique , mitochondrion capability , non-skeletal muscle mass exponent , characteristic skeletal length , and ...
nichd_parent_of
{ "id": "C1521970", "name": "characteristic", "pos": [ 283, 297 ] }
{ "id": "C1444754", "name": "length", "pos": [ 307, 313 ] }
river waters were found to be contaminated with various species of enteric viruses , that is , poliovirus , echovirus , coxsackievirus , adenovirus , and reovirus .
nichd_parent_of
{ "id": "C0042776", "name": "viruses", "pos": [ 75, 82 ] }
{ "id": "C0206435", "name": "poliovirus", "pos": [ 95, 105 ] }
we studied sex differences in the serum lipid abnormalities associated with diabetes mellitus in 111 patients with insulin-dependent diabetes and 270 patients with non-insulin-dependent diabetes , who were compared with 586 nondiabetic controls .
nichd_parent_of
{ "id": "C0011849", "name": "diabetes mellitus", "pos": [ 76, 93 ] }
{ "id": "C0011854", "name": "insulin-dependent diabetes", "pos": [ 168, 194 ] }
these latter organisms were selected as typical filamentous and yeastlike monophasic fungi , and their ribosomes were used as reference standards .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 13, 22 ] }
{ "id": "C0016832", "name": "fungi", "pos": [ 85, 90 ] }
clinically significant arrhythmias ( greater than 100 ventricular extrasystoles/24 h ) were found in only 1 patient and there were no complex ventricular arrhythmias .
nichd_parent_of
{ "id": "C0003811", "name": "arrhythmias", "pos": [ 23, 34 ] }
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 142, 165 ] }
natural killer ( nk ) cell function against the nk cell-sensitive myeloid leukemia cell line , k562 , was measured in the peripheral blood mononuclear cells ( pbmcs ) of 17 patients with primary brain tumors ( 4 diagnosed as having low grade tumors and 13 diagnosed as having high grade ( malignant ) tumors ) .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 201, 207 ] }
{ "id": "C0006826", "name": "malignant", "pos": [ 289, 298 ] }
phagocytes isolated from either normal donors or from patients with poststreptococcal ( p-sgn ) , lupus erythematosus ( sle-gn ) , or membranoproliferative ( mpgn ) glomerulonephritis showed normal adherence to glass ( pag ) after incubation in normal human serum ( nhs ) , but was reduced after incubation in patient se...
nichd_parent_of
{ "id": "C0409974", "name": "lupus erythematosus", "pos": [ 98, 117 ] }
{ "id": "C0024141", "name": "sle", "pos": [ 120, 123 ] }
despite lower energy storage , sga infants were gaining weight ( 19.4 +/- 0.9 g/kg x day ) , length ( 1.25 +/- 0.14 cm/week ) , and head circumference ( 1.16 +/- 0.9 cm/week ) at higher rates than the aga group .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 93, 99 ] }
{ "id": "C0262499", "name": "head circumference", "pos": [ 132, 150 ] }
even after adjustment for other relevant variables , maternal alcohol use during early pregnancy ( average ounces of absolute alcohol by self-report ) was significantly related to infant weight and length at 8 months of age but not as strongly related to head circumference .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 198, 204 ] }
{ "id": "C0262499", "name": "head", "pos": [ 255, 259 ] }
[ hypercoagulemic disorders of hemostasis and disseminated intravascular coagulation syndromes ( clinical , diagnostic , treatment and prophylactic problems ) ] .
nichd_parent_of
{ "id": "C0005779", "name": "disorders of hemostasis", "pos": [ 18, 41 ] }
{ "id": "C0012739", "name": "disseminated intravascular", "pos": [ 46, 72 ] }
renal disease appears therefore as the sixth cardinal features of the lmbb syndrome and makes this syndrome as an entity close to other hereditary disorders with renal abnormalities as alstrom syndrome .
nichd_parent_of
{ "id": "C0039082", "name": "syndrome", "pos": [ 75, 83 ] }
{ "id": "C0268425", "name": "alstrom", "pos": [ 185, 192 ] }
otitis media is one of the most common infectious diseases of childhood , and many children have many episodes in infancy .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 62, 71 ] }
{ "id": "C0231330", "name": "infancy", "pos": [ 114, 121 ] }
in the in vitro experiments , vip ( 10 ( -8 ) , 10 ( -7 ) and 10 ( -6 ) m ) stimulated prl release in a dose-related manner from the superfused pituitary adenoma cells obtained from two patients with prolactinoma .
nichd_parent_of
{ "id": "C0032000", "name": "pituitary adenoma", "pos": [ 144, 161 ] }
{ "id": "C0033375", "name": "prolactinoma", "pos": [ 200, 212 ] }
it was concluded ( a ) the occ procedure in the dog has the capacity to subtotal destruction of the pancreatic acinar tissue , and of the entero-insular axis of insulin , the latter through yet unknown pathways , ( b ) the occ technique may be a useful tool for investigation of the nature of `` '' incretin , '' '' ( c ...
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 31, 40 ] }
{ "id": "C0220825", "name": "investigation", "pos": [ 262, 275 ] }
the best approach to evaluation of a mediastinal mass begins with a history and a physical examination that are oriented toward discovery of evidence of compression or obstruction to any of the mediastinal organs .
nichd_parent_of
{ "id": "C0220825", "name": "evaluation", "pos": [ 21, 31 ] }
{ "id": "C0031809", "name": "physical examination", "pos": [ 82, 102 ] }
mastery of the art of listening to vocal abnormalities will enable the clinician to determine which patients he or she can treat at the outset and which require immediate referral to a laryngologist or other specialist .
nichd_parent_of
{ "id": "C0087111", "name": "treat", "pos": [ 123, 128 ] }
{ "id": "C0034927", "name": "referral", "pos": [ 171, 179 ] }
cross-reactions of a number of glycans and polysaccharides isolated from fungi , molds , and yeasts in anti-pneumococcal and other antisera are tabulated and discussed insofar as possible with relation to the chemical structures of the cross-precipitating substances and the polysaccharidic antigens giving rise to the r...
nichd_parent_of
{ "id": "C0016832", "name": "fungi", "pos": [ 73, 78 ] }
{ "id": "C0369241", "name": "molds", "pos": [ 81, 86 ] }
cross-reactions of a number of glycans and polysaccharides isolated from fungi , molds , and yeasts in anti-pneumococcal and other antisera are tabulated and discussed insofar as possible with relation to the chemical structures of the cross-precipitating substances and the polysaccharidic antigens giving rise to the r...
nichd_parent_of
{ "id": "C0016832", "name": "fungi", "pos": [ 73, 78 ] }
{ "id": "C0043393", "name": "yeasts", "pos": [ 93, 99 ] }
sixteen virus plaque reduction units of the inhibitor diminished the yield of poliovirus in vitro by more than 1000-fold .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 8, 13 ] }
{ "id": "C0206435", "name": "poliovirus", "pos": [ 78, 88 ] }
when the relative frequency of specific site of 137 malignancies is concerned , we did see a few more cases of leukemia and melanoma than the seer 's data .
nichd_parent_of
{ "id": "C0006826", "name": "malignancies", "pos": [ 52, 64 ] }
{ "id": "C0025202", "name": "seer 's", "pos": [ 142, 149 ] }
ionic concentrations in individual sets of samples show that the proportions of tracheal and amniotic fluids swallowed by the fetus are variable from day to day .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 24, 34 ] }
{ "id": "C0015965", "name": "fetus", "pos": [ 126, 131 ] }
a pattern-recognition approach coupled with pertinent clinical findings can often lead to diagnosis of a specific disease entity .
nichd_parent_of
{ "id": "C0037088", "name": "clinical findings", "pos": [ 54, 71 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 90, 99 ] }
this finding may aid in making a specific diagnosis in patients with a pituitary mass .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 5, 12 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 42, 51 ] }
ct appears to be advantageous in detecting substernal thyroid extension and confirming thyroiditis , while the ability of us to detect small nodules makes it the procedure of choice in evaluating suspected intrinsic thyroid abnormalities .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 162, 171 ] }
{ "id": "C0220825", "name": "evaluating", "pos": [ 185, 195 ] }
complete removal of leucocytes and platelets from erythrocytes and the development of a sensitized procedure for the assay of g6pd activity allowed the biochemical mechanisms of the mediterranean variety of g6pd deficiency to be re-evaluated .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 99, 108 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 232, 241 ] }
today more than 80 % of the pathogenic agents can be found : virus ( rotavirus and virus of norwalk ) , bacteria or parasites .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 61, 66 ] }
{ "id": "C0035870", "name": "rotavirus", "pos": [ 69, 78 ] }
radionuclide labels have been essential for the elucidation of various hematologic disorders , such as the neutropenias , thrombocytopenias , anemias , and polycythemia .
nichd_parent_of
{ "id": "C0018939", "name": "hematologic disorders", "pos": [ 71, 92 ] }
{ "id": "C0002871", "name": "anemias", "pos": [ 142, 149 ] }
no significant increase in cardiac dysrhythmias such as bradycardia , atrial and ventricular extrasystoles was found ( p greater than 0,01 ) , but a significant increase in tachycardia occurred during induction ( p less than 0,05 ) and intubation ( p less than 0,01 ) .
nichd_parent_of
{ "id": "C0003811", "name": "cardiac dysrhythmias", "pos": [ 27, 47 ] }
{ "id": "C0428977", "name": "bradycardia", "pos": [ 56, 67 ] }
a high risk of death was associated with an age of 65 years or over , absence of pyrexia , absence of a leucocyte response , disease affecting multiple lobes , irreversible hypotension , underlying neoplasm , and failure to respond to penicillin treatment ( p less than 0.001 in all cases ) .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 125, 132 ] }
{ "id": "C0027651", "name": "neoplasm", "pos": [ 198, 206 ] }
sgp sensitivity in acute proximal venous thrombosis was 97 % , while it was about 60 % in distal dvt .
nichd_parent_of
{ "id": "C0042487", "name": "venous thrombosis", "pos": [ 34, 51 ] }
{ "id": "C0149871", "name": "dvt", "pos": [ 97, 100 ] }
during the study period a diagnosis of cvd ( initial stroke or tia ) was reported in 2,103 individuals , giving annual average crude incidence rates for stroke and tia of 34 and 4 respectively per 100,000 inhabitants under age 55 .
nichd_parent_of
{ "id": "C0038454", "name": "stroke", "pos": [ 53, 59 ] }
{ "id": "C0007787", "name": "tia", "pos": [ 164, 167 ] }
sociological and behavioral factors can also influence a woman 's decision to initiate and terminate breastfeeding .
nichd_parent_of
{ "id": "C0004927", "name": "behavioral", "pos": [ 17, 27 ] }
{ "id": "C0006147", "name": "breastfeeding", "pos": [ 101, 114 ] }
in connection with the evaluation of hospital infections , the investigations of several authors indicate a rate of about 25 % of surgical wound infections .
nichd_parent_of
{ "id": "C3714514", "name": "infections", "pos": [ 46, 56 ] }
{ "id": "C0038941", "name": "surgical wound infections", "pos": [ 130, 155 ] }
the experimental calves had been selected on the basis of freedom from clinical evidence of respiratory and other diseases , freedom from current infection by pi3 virus as judged by repeated nasopharyngeal swabbing and freedom from earlier pi3 virus infection as judged by their lack of significant levels of serum antib...
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 114, 122 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 250, 259 ] }
diagnostic tests , utilizing monoclonal antibodies , have included radioimmunoassay ( ria ) and enzyme-linked immunosorbent assay ( elisa ) techniques to detect parasite antigen in host tissues and body fluids and circulating host antiparasite antibody .
nichd_parent_of
{ "id": "C0005889", "name": "body", "pos": [ 198, 202 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 244, 252 ] }
to define this frequency in a given type of malignancy we have studied the nephrectomy kidneys in 40 patients with renal cell carcinoma .
nichd_parent_of
{ "id": "C0006826", "name": "malignancy", "pos": [ 44, 54 ] }
{ "id": "C0007134", "name": "renal cell carcinoma", "pos": [ 115, 135 ] }
the association of optic nerve hypoplasia and deficiency of the septum pellucidum and hypopituitarism is known as the de morsier syndrome or septo-optic dysplasia .
nichd_parent_of
{ "id": "C0338502", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C0338503", "name": "septo-optic dysplasia", "pos": [ 141, 162 ] }
many diseases may present as acute hepatic failure in the pediatric age group , including viral hepatitis a and b , adverse drug reactions , both toxic and `` '' hepatitic , '' '' and inherited metabolic disorders such as tyrosinemia , alpha 1 antitrypsin deficiency , and wilson 's disease .
nichd_parent_of
{ "id": "C0019247", "name": "d inherit", "pos": [ 182, 191 ] }
{ "id": "C0221757", "name": ", alpha", "pos": [ 234, 241 ] }
in varying numbers out of a total of 88 nephropathy patients with varying degrees of insufficiency ( 22 patients without restriction of kidney function , 53 patients with chronic renal insufficiency in the stage of compensated retention and 13 haemodialysis patients ) the schilling test was performed and the serum vita...
nichd_parent_of
{ "id": "C0022658", "name": "nephropathy", "pos": [ 40, 51 ] }
{ "id": "C0022661", "name": "chronic renal insufficiency", "pos": [ 171, 198 ] }
the advantages and disadvantages of this procedure are discussed and compared with other surgical procedures .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 41, 50 ] }
{ "id": "C0543467", "name": "surgical procedures", "pos": [ 89, 108 ] }
[ differential choice of the procedure in the surgical treatment of fractures in the trochanteric area ] .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 29, 38 ] }
{ "id": "C0543467", "name": "surgical treatment", "pos": [ 46, 64 ] }
using radioimmunoassay the authors studied concentrations of beta-endorphine and metenkephalin in the cerebrospinal fluid ( csf ) of 65 patients with various diseases of the central nervous system ( cns ) -- hereditary extrapyramidal disorders , disseminated sclerosis ( ds ) , lateral amyotrophic sclerosis ( las ) , sp...
nichd_parent_of
{ "id": "C0007682", "name": "diseases of the central nervous system", "pos": [ 158, 196 ] }
{ "id": "C0026769", "name": "disseminated sclerosis", "pos": [ 246, 268 ] }
as some tumors can produce and secrete serumferritin , e. g. acute myeloblastic leukemia , germ cell tumors , malignant melanoma , serumferritin might be helpful in monitoring the malignant disease .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 8, 14 ] }
{ "id": "C0205851", "name": "germ cell tumors", "pos": [ 91, 107 ] }
the potential role of neurotransmitter dysfunction in the pathophysiology of neurologic and behavior disorders of children , should not be considered as restricted to those disorders that involve selective neuronal loss , but may encompass a much wider spectrum of syndromes due to metabolic abnormalities , as well as d...
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 101, 110 ] }
{ "id": "C0039082", "name": "syndromes", "pos": [ 265, 274 ] }
the frequency of subclinical cancer demonstrated by mammography in this material was higher than the prevalence of mammary carcinoma found by screening of risk group populations .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 29, 35 ] }
{ "id": "C0678222", "name": "mammary carcinoma", "pos": [ 115, 132 ] }
whereas dysplastic changes of menisci were the main causes for meniscectomy in childhood , traumatic lesions of the menisci were prominent in adolescence .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 79, 88 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 142, 153 ] }
prophylactic irradiation was given to the patient with stage i disease and no relapse occurred in the irradiated area , but later , neoplasms had spread by vascular dissemination in 3 cases ( 17.6 % ) .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 63, 70 ] }
{ "id": "C0027651", "name": "neoplasms", "pos": [ 132, 141 ] }
high levels of immune complexes have been detected in the serum of patients with malignant solid tumours , leukemias and lymphomas .
nichd_parent_of
{ "id": "C0006826", "name": "malignant", "pos": [ 81, 90 ] }
{ "id": "C0024299", "name": "lymphomas", "pos": [ 121, 130 ] }
black-white comparison of indices of coronary heart disease and myocardial infarction in the stepped-care cohort of the hypertension detection and follow-up program .
nichd_parent_of
{ "id": "C0018799", "name": "of", "pos": [ 23, 25 ] }
{ "id": "C0027051", "name": "myocardial", "pos": [ 64, 74 ] }
the cholestyramine group had a 19 % reduction in risk ( p less than 0.05 ) of the primary endpoint of definite chd , death or definite nonfatal myocardial infarction .
nichd_parent_of
{ "id": "C0018799", "name": "of the", "pos": [ 75, 81 ] }
{ "id": "C0027051", "name": "myocardial infarction", "pos": [ 144, 165 ] }
serial sections from the angiographically localized occlusive site of the infarct vessel , and transverse slices of the heart stained with nitroblue tetrazolium for delineation of mi , were examined by light microscopy .
nichd_parent_of
{ "id": "C0021308", "name": "infarct", "pos": [ 74, 81 ] }
{ "id": "C0027051", "name": "mi", "pos": [ 208, 210 ] }
the combination of osteopathia striata , macrocephaly , and cranial sclerosis , variably associated with certain other congenital anomalies , constitutes a rare autosomal dominant malformation syndrome .
nichd_parent_of
{ "id": "C0000768", "name": "congenital anomalies", "pos": [ 119, 139 ] }
{ "id": "C1302790", "name": "malformation syndrome", "pos": [ 180, 201 ] }
we collected extensive data on both parents and children , hypothesizing that drugs can affect infants through a variety of causal routes .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 48, 56 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 95, 102 ] }
the origin of these changes in altered court policy or procedure , population growth , or increasing rates of mental disability awaits further investigation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 55, 64 ] }
{ "id": "C0220825", "name": "investigation", "pos": [ 143, 156 ] }
myocardial function and perfusion were evaluated in 22 patients with progressive systemic sclerosis with the crest syndrome using exercise and radionuclide techniques , pulmonary function testing , and chest roentgenography .
nichd_parent_of
{ "id": "C0036421", "name": "progressive", "pos": [ 69, 80 ] }
{ "id": "C0206138", "name": "crest syndrome", "pos": [ 109, 123 ] }
the prevalence of thallium perfusion abnormalities was similar in the groups with crest syndrome and diffuse scleroderma , ( 64 percent versus 77 percent ) , but the defects were significantly smaller in the crest syndrome ( p less than 0.01 ) .
nichd_parent_of
{ "id": "C0036421", "name": "diffuse", "pos": [ 101, 108 ] }
{ "id": "C0206138", "name": "crest syndrome", "pos": [ 208, 222 ] }
unlike diffuse scleroderma , abnormalities of left ventricular function in the crest syndrome are minor and are unrelated to abnormalities of coronary perfusion .
nichd_parent_of
{ "id": "C0036421", "name": "diffuse scleroderma", "pos": [ 7, 26 ] }
{ "id": "C0206138", "name": "crest syndrome", "pos": [ 79, 93 ] }
graves ' disease in pregnancy years after hypothyroidism with recurrent passive-transfer neonatal graves ' disease in offspring .
nichd_parent_of
{ "id": "C0018213", "name": "graves", "pos": [ 0, 6 ] }
{ "id": "C0271767", "name": "neonatal graves", "pos": [ 89, 104 ] }
following apparently successful therapy with intravenous amphotericin b , he presented two months later with a subacute pneumonitis syndrome diagnosed by bronchoscopy as pneumocystis carinii pneumonia .
nichd_parent_of
{ "id": "C0032285", "name": "pneumonitis", "pos": [ 120, 131 ] }
{ "id": "C1535939", "name": "pneumocystis carinii pneumonia", "pos": [ 170, 200 ] }
in a recent report [ odenheimer et al , 1983 ] , we used the values of the six hematological variables collected at an individual 's first visit to the sickle cell center to identify four hematologically distinct subgroups of children .
nichd_parent_of
{ "id": "C0027361", "name": "individual 's", "pos": [ 119, 132 ] }
{ "id": "C0008059", "name": "children", "pos": [ 226, 234 ] }
a prospective study was conducted to determine the frequency , spacing , and outcome of pregnancies that occur subsequent to primary cesarean childbirth .
nichd_parent_of
{ "id": "C0032972", "name": "outcome of pregnancies", "pos": [ 77, 99 ] }
{ "id": "C0007876", "name": "cesarean childbirth", "pos": [ 133, 152 ] }
in these neoplasms a nearly intact basement membrane was seen both in malignant tumors and in their benign counterparts .
nichd_parent_of
{ "id": "C0027651", "name": "neoplasms", "pos": [ 9, 18 ] }
{ "id": "C0006826", "name": "malignant", "pos": [ 70, 79 ] }
we suggest that anesthesia for inguinal herniorrhaphy is most satisfactorily provided by the combination of a short-acting regional anesthetic agent and a long-acting local one .
nichd_parent_of
{ "id": "C0002903", "name": "anesthesia", "pos": [ 16, 26 ] }
{ "id": "C0002921", "name": "regional anesthetic", "pos": [ 123, 142 ] }
[ clinico-bacteriological characteristics of children born to mothers with risk factors of pre- and intranatal infection of the fetus and newborn infant ] .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 45, 53 ] }
{ "id": "C0021289", "name": "newborn infant", "pos": [ 138, 152 ] }
complications included persistent pvcs requiring therapy in 193 ( 3.1 % ) , right bundle branch blocks in three ( 0.048 % ) , left bundle branch and complete heart block each in one patient ( 0.016 % ) , intrapulmonary hemorrhage in four ( 0.064 % ) , minor pulmonary infarcts in four ( 0.064 % ) , perforation of right ...
nichd_parent_of
{ "id": "C0019080", "name": "hemorrhage", "pos": [ 219, 229 ] }
{ "id": "C0151701", "name": "pulmonary hemorrhage", "pos": [ 381, 401 ] }
the 3 calves , inoculated with bvd virus only , developed mild clinical signs mainly manifested as fever , nasal discharge , and occasional cough .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 63, 77 ] }
{ "id": "C0015967", "name": "fever", "pos": [ 99, 104 ] }
the 3 calves , inoculated with bvd virus only , developed mild clinical signs mainly manifested as fever , nasal discharge , and occasional cough .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 63, 77 ] }
{ "id": "C1260880", "name": "nasal discharge", "pos": [ 107, 122 ] }
the 3 calves , inoculated with bvd virus only , developed mild clinical signs mainly manifested as fever , nasal discharge , and occasional cough .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 63, 77 ] }
{ "id": "C0010200", "name": "cough", "pos": [ 140, 145 ] }
our data indicated that the congenital platelet dysfunction does not become more severe in older animals and that the nephropathy seems unrelated , does not appear to be mediated by immune complexes , and , in contrast to the focal segmental glomerulosclerosis of persons , the lesions progress without a parallel impair...
nichd_parent_of
{ "id": "C0022658", "name": "nephropathy", "pos": [ 118, 129 ] }
{ "id": "C0017668", "name": "focal segmental glomerulosclerosis", "pos": [ 226, 260 ] }
our data indicated that the congenital platelet dysfunction does not become more severe in older animals and that the nephropathy seems unrelated , does not appear to be mediated by immune complexes , and , in contrast to the focal segmental glomerulosclerosis of persons , the lesions progress without a parallel impair...
nichd_parent_of
{ "id": "C0022658", "name": "nephropathy", "pos": [ 118, 129 ] }
{ "id": "C0035078", "name": "impairment", "pos": [ 314, 324 ] }
clinical signs of the deficit observed included polydipsia , polyuria , dehydration , anorexia , scleral injection , decreased respiratory rate , and blood and mucus in the feces .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0003123", "name": "anorexia", "pos": [ 86, 94 ] }
the difference in response rates occurred primarily in patients with rapidly fatal underlying disease or with an infection outside the urinary tract .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 94, 101 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 113, 122 ] }
in a series of 184 patients with iga glomerulonephritis ( iga gn ) 114 ( 62 % ) had concomitant diseases compared with 35 ( 36 % ) in a control series consisting of 96 patients with mesangial glomerulonephritis of other type than iga gn .
nichd_parent_of
{ "id": "C0017658", "name": "glomerulonephritis", "pos": [ 37, 55 ] }
{ "id": "C0017661", "name": "iga gn", "pos": [ 230, 236 ] }
we may conclude that lip [ mtx , anti-hcg ] has a specific inhibitory effect on the growth of choriocarcinoma cells in vitro , which suggests the possibility of a specific immunochemotherapy for this disease , using the specific antibody to this tumor coupled to liposomes .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 200, 207 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 246, 251 ] }
the highest therapeutic effectiveness was obtained when spg injection was started at an advanced stage of the tumor , 4 out of 15 rats treated being completely cured of cancer .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 110, 115 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 169, 175 ] }
a major dietary effect on the number of days taken to regain birthweight and subsequent gains in weight , length , and head circumference was observed in the primary trial .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 106, 112 ] }
{ "id": "C0262499", "name": "head circumference", "pos": [ 119, 137 ] }
to elucidate a possible role for eosinophils in inflammatory joint reactions the concentrations of eosinophil cationic protein ( ecp ) -- a specific granule protein from eosinophils -- were measured by radioimmunoassay in 90 synovial fluids from patients with various inflammatory arthritides ( rheumatoid arthritis , re...
nichd_parent_of
{ "id": "C0003864", "name": "inflammatory arthritides", "pos": [ 268, 292 ] }
{ "id": "C0003873", "name": "rheumatoid arthritis", "pos": [ 295, 315 ] }
to elucidate a possible role for eosinophils in inflammatory joint reactions the concentrations of eosinophil cationic protein ( ecp ) -- a specific granule protein from eosinophils -- were measured by radioimmunoassay in 90 synovial fluids from patients with various inflammatory arthritides ( rheumatoid arthritis , re...
nichd_parent_of
{ "id": "C0003864", "name": "inflammatory arthritides", "pos": [ 268, 292 ] }
{ "id": "C0003872", "name": "psoriatic arthropathy", "pos": [ 375, 396 ] }
these results suggest that an antireflux procedure should not be added to modified heller 's operation in the treatment of achalasia .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 41, 50 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 93, 102 ] }
eleven tumors were granulosa cell tumors of the adult type , and six tumors were juvenile granulosa cell tumors .
nichd_parent_of
{ "id": "C0018206", "name": "granulosa cell tumors", "pos": [ 19, 40 ] }
{ "id": "C0334403", "name": "juvenile granulosa cell tumors", "pos": [ 81, 111 ] }
inversion stress radiography under full anesthesia showed a reliability of 92 % , but the same investigation under local anesthesia , however , was only 68 % .
nichd_parent_of
{ "id": "C0002903", "name": "anesthesia", "pos": [ 40, 50 ] }
{ "id": "C0002921", "name": "local anesthesia", "pos": [ 115, 131 ] }
the degree of p14 accumulation could be directly correlated with the severity of the disease symptoms and its concentration was found to be highest in leaves of the tomato cultivar `` '' rutgers '' '' four weeks after infection .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 85, 92 ] }
{ "id": "C0009450", "name": "infecti", "pos": [ 218, 225 ] }
the molecular characteristics of the antigens detected by the moab bw 181/26 and bw 166/6 are described .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 14, 29 ] }
{ "id": "C0005910", "name": "bw", "pos": [ 81, 83 ] }
neither quantitative nor qualitative differences could be detected between biopsies taken from healthy as compared to diseased individuals .
nichd_parent_of
{ "id": "C0205556", "name": "qualitative", "pos": [ 25, 36 ] }
{ "id": "C0018684", "name": "healthy", "pos": [ 95, 102 ] }
the diagnosis was in 37 cases non malignant diseases states associated with effusions and in 71 cases tumoral effusions .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 44, 52 ] }
{ "id": "C0027651", "name": "tumoral", "pos": [ 102, 109 ] }
among the 71 cases of tumoral effusions were 3 benign pleural lipomas , 50 metastatic carcinomas , 18 carcinomatous mesotheliomas .
nichd_parent_of
{ "id": "C0027651", "name": "tumoral", "pos": [ 22, 29 ] }
{ "id": "C0023798", "name": "benign", "pos": [ 47, 53 ] }
we studied the diagnostic accuracy of pleural brushing : in non malignant diseases , pleural brushing show the non tumoral features of the process , in metastatic tumours , biopsy was positive in 80 % of the cases ;
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 74, 82 ] }
{ "id": "C0027651", "name": "tumoral", "pos": [ 115, 122 ] }