text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the mrna of a human class i gene hla g/hla 6.0 exhibits a restricted pattern of expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C0017355",
"name": "class i gene",
"pos": [
20,
32
]
} |
the mrna of a human class i gene hla g/hla 6.0 exhibits a restricted pattern of expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1415587",
"name": "hla",
"pos": [
39,
42
]
} |
we have recently shown that chinese hamster ovary cells transfected with the human tnf gene and which constitutively express tnf induced a hypoproliferative anemia , mild thrombocytopenia , and mild leukocytosis when injected into nude mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C1710304",
"name": "tnf gene",
"pos": [
83,
91
]
} |
the growth of human pancreatic cancer lines panc-1 and mia paca-2 was characterized in vitro , and the effects of cholecystokinin , bombesin , insulin , epidermal growth factor , secretin , vasoactive intestinal peptide , and somatostatin were determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
55,
58
]
} |
to gain insight to the mechanisms underlying region-specific gene expression in mammalian development , we investigated the regulatory dna associated with the proximal promoter of two homeo box genes , murine hox-1.3 and human hox-5.1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
221,
226
]
} | {
"id": "C1415652",
"name": "hox",
"pos": [
227,
230
]
} |
this serum-induced ccaat factor also bound ccaat sequences from other promoters , for example , those of human heat shock protein 70 , human c-ha-ras , and human histone 1 , but not to the adenovirus origin of replication or the sv40 enhancer core sequence , suggesting that it was related to cp1 or cp2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
105,
110
]
} | {
"id": "C1456377",
"name": "cp2",
"pos": [
300,
303
]
} |
the rate of occurrence of pregnancy following ivf-et ( in vitro fertilization plus embryo transfer ) is still very low considering the advancement of human ivf technology in the last ten years . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
150,
155
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
156,
159
]
} |
optimization and simplification of culture conditions in human in vitro fertilization ( ivf ) and preembryo replacement by serum-free media . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
88,
91
]
} |
the serum and tpa responsive promoter and intron-exon structure of egr2 , a human early growth response gene encoding a zinc finger protein . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
76,
81
]
} | {
"id": "C0599295",
"name": "early",
"pos": [
82,
87
]
} |
reciprocal expression of human ets1 and ets2 genes during t-cell activation : regulatory role for the protooncogene ets1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0812202",
"name": "ets2 genes",
"pos": [
40,
50
]
} |
reciprocal expression of human ets1 and ets2 genes during t-cell activation : regulatory role for the protooncogene ets1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1705691",
"name": "protooncogene ets1",
"pos": [
102,
120
]
} |
a 31-base-pair sequence found approximately 420 base pairs upstream of the gene encoding human transforming growth factor beta 1 acted as a ras-responsive enhancer element in transient transfection assays . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
140,
143
]
} |
monoclonal antibodies to the sheep analogues of human cd45 ( leucocyte common antigen ) , mhc class i and cd5 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0017355",
"name": "mhc class i",
"pos": [
90,
101
]
} |
analysis of the larger sequence indicated that it shared 93.9 % and 90.9 % homology with the first 33 amino acids of human and rabbit plasma retinol-binding protein ( rbp ) , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C1419320",
"name": "plasma",
"pos": [
134,
140
]
} |
these new assignments on rat chromosome 5 demonstrate that this chromosome is highly homologous to mouse chromosome 4 and carries synteny groups conserved on human chromosome 9 ( interferon alpha and beta , galactosyltransferase , orosomucoid , and aldolase b genes ) and on the short arm of human chromosome 1 ( mycl , glucose transporter , protein kinase lck , and atrial natriuretic factor genes ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
158,
163
]
} | {
"id": "C0812289",
"name": "mycl",
"pos": [
313,
317
]
} |
we analyzed the ultrastructure of scanning transmission electron microscope images of bovine and human fv , bovine fva , and its constituent light chains and heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
158,
170
]
} |
the analysis of p40 genomic clones reported here shows that the human and mouse p40 genes consist of 5 exons spread over approximately 4 kb of dna and organized in a similar fashion in both species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C1708439",
"name": "p40 genes",
"pos": [
80,
89
]
} |
prediction of the resistance of human tumors to adriamycin by chemosensitivity tests and dna analysis of the multidrug resistance gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C0376623",
"name": "multidrug resistance gene",
"pos": [
109,
134
]
} |
to identify cis-acting dna elements responsible for this type of regulation , we constructed a plasmid in which cat gene expression was driven by about 1 kilobase of upstream k-fgf human dna sequences , including the putative promoter , and transfected it into undifferentiated f9 ec cells or hela cells as prototypes of cells which express or do not express , respectively , the k-fgf proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
181,
186
]
} | {
"id": "C0919466",
"name": "k-fgf",
"pos": [
380,
385
]
} |
on the other hand , when we inserted in this plasmid dna sequences which are 3 ' of the human k-fgf coding sequences , we could detect a significant stimulation of cat activity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C0919466",
"name": "k-fgf",
"pos": [
94,
99
]
} |
analysis of these sequences led to the identification of enhancerlike dna elements which are part of the 3 ' noncoding region of k-fgf exon 3 and promote cat expression only in undifferentiated mouse f9 or human nt2/d1 ec cells , but not in hela , 3t3 , or differentiated f9 cells , therefore mimicking the physiological expression of the k-fgf proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
206,
211
]
} | {
"id": "C0919466",
"name": "k-fgf",
"pos": [
339,
344
]
} |
similar elements are also present in the 3 ' region of the murine k-fgf proto-oncogene , in a region showing high homology to the human k-fgf sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
130,
135
]
} | {
"id": "C0919466",
"name": "k-fgf",
"pos": [
136,
141
]
} |
transcription of the human c-fps/fes transgene was highest in bone marrow and showed a tissue distribution identical to that of the endogenous mouse gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
29,
32
]
} |
macrophages cultured from transgenic mouse bone marrow contained particularly high levels of human and murine c-fps/fes rna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
93,
98
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
112,
115
]
} |
furthermore , expression of human c-fps/fes rna induced a proportionate increase in the level of the p92c-fes protein-tyrosine kinase in bone marrow , bone marrow-derived macrophages , and spleen . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
36,
39
]
} |
remarkably , given the short 5'- and 3'-flanking sequences , expression of the human proto-oncogene in bone marrow was independent of integration site , was proportional to the transgene copy number , and was of comparable efficiency to that of the endogenous mouse c-fps/fes gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
79,
84
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
268,
271
]
} |
insulin-like growth factor binding proteins ( bp ) from human placenta are immunologically related to the growth hormone dependent binding protein in adult human serum ( bp-53 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1334094",
"name": "bp-53",
"pos": [
170,
175
]
} |
this maids model may allow rapid and cost-effective screening for antiretrovirus drugs targeted against retroviral functions shared between human aids and maids , such as those encoded by gag , pol , or env . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
104,
114
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
194,
197
]
} |
this maids model may allow rapid and cost-effective screening for antiretrovirus drugs targeted against retroviral functions shared between human aids and maids , such as those encoded by gag , pol , or env . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
104,
114
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
203,
206
]
} |
isolation of a cdna encoding human rev-erba alpha : transcription from the noncoding dna strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C1417821",
"name": "rev-erba alpha",
"pos": [
35,
49
]
} |
isolation of a cdna encoding human rev-erba alpha : transcription from the noncoding dna strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C0919499",
"name": "thyroid hormone receptor gene",
"pos": [
101,
130
]
} |
this cdna contains 269 consecutive base pairs identical to a region of a human c-erba alpha-2 cdna , but the respective long open reading frames utilize this nucleotide sequence in opposite orientations . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
81,
85
]
} |
thus , human rev-erba alpha ( hrev ) is derived from opposite-strand transcription of the c-erba alpha genomic locus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1417821",
"name": "rev-erba alpha",
"pos": [
13,
27
]
} |
interestingly , the human and rat rev-erba alpha cdnas are dissimilar at their 5 ' ends , corresponding to the first exon that we have identified in the rat gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1417821",
"name": "rev-erba alpha",
"pos": [
34,
48
]
} |
cyclophosphamide-treated mice received human ril-1 beta at 7.0 , 0.7 , or 00.7 micrograms/kg , according to different regimens , to be challenged with a lethal ip inoculum of pseudomonas cells 5 days after myelosuppression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
45,
48
]
} |
three members of the myb gene family have been identified in human cdna libraries c-myb , a-myb , and b-myb . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0812291",
"name": "b-myb",
"pos": [
102,
107
]
} |
an enhancer element in the 5 ' flanking region of the human apolipoprotein e gene , known as upstream regulatory element 1 ( ure1 ) , has previously been implicated in the expression of this gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C1412481",
"name": "apolipoprotein e",
"pos": [
60,
76
]
} |
the human c-myb proto-oncogene is the cellular progenitor of the viral v-myb oncogene and codes for a 75 kd protein involved in growth regulation and differentiation in a number of cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0026900",
"name": "v-myb",
"pos": [
71,
76
]
} |
a 1.26 kb murine cdna having 31 % homology with human ras and 55 % homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
54,
57
]
} |
we have studied lepromatous leprosy ( ll ) as a human model disease for t-cell non-responsiveness to specific mycobacterial antigens and studied the effect of ril-4 , ril-2 , rifn-gamma and rtnf-alpha thereon . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
167,
170
]
} |
taken together , these results demonstrate that human colon tumors usually display increased levels of both phorbin and c-myc rnas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
120,
125
]
} |
by a combination of pulsed-field gel electrophoresis and molecular cloning techniques , the human cd3-gamma , cd3-delta and cd3-epsilon genes have been shown to be clustered in approximately 50 kb of chromosome 11q23 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
92,
97
]
} | {
"id": "C1705090",
"name": "cd3-epsilon genes",
"pos": [
124,
141
]
} |
the human class i alcohol dehydrogenase gene cluster : three genes are tandemly organized in an 80-kb-long segment of the genome . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
10,
17
]
} |
three human class i adh genes , adh1 , adh2 , and adh3 , which encode the alpha , beta , and gamma subunits respectively , have been isolated and mapped on chromosome 4q21-q23 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
6,
11
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
12,
19
]
} |
a human/mouse chimeric monoclonal antibody specific for a common acute lymphocytic leukemia antigen was efficiently obtained by ligating human heavy-chain enhancer element to the chimeric heavy- and light-chain genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
2,
7
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
143,
154
]
} |
stimulation of normal human monocytes with lipopolysaccharide ( lps ) results in the transcription of interleukin-1 ( il-1 ) genes , the intracellular accumulation of il-1 alpha and il-1 beta precursors , and the subsequent extracellular release of functional il-1 beta . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C1708431",
"name": "interleukin-1",
"pos": [
102,
115
]
} |
expression from a virally transferred gamma- or beta-globin gene exceeded endogenous gamma- or beta-globin expression by a factor of 6 or more in the human erythroleukemia line kmoe , in which the endogenous globin genes are weakly inducible . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
150,
155
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
208,
220
]
} |
human alloantisera specific for either the baka or bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein ( gp ) iib . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
109,
120
]
} |
tgf-beta 1-bp purified from human platelets is considerably smaller than the fibroblast form ( 125-160 kd vs. 170-190 kd ) , suggesting that there is alternative splicing of the tgf-beta 1-bp gene or that tgf-beta 1-bp undergoes cell-specific proteolysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1366557",
"name": "tgf-beta 1-bp",
"pos": [
205,
218
]
} |
these vectors express a ) a chicken cam gene regulated by its own promoter ( cm cells ) , b ) the chicken cam gene regulated by the inducible human metallothionein-iia promoter ( mcm cells ) , c ) cam antisense rna using the zn2+ inducible mouse metallothionein-i ( mmt-i ) promoter ( as cells ) , or d ) a rat parvalbumin gene using the chicken cam promoter ( pv cells ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
142,
147
]
} | {
"id": "C1709402",
"name": "mcm",
"pos": [
179,
182
]
} |
the value of various sperm parameters and the zona-free hamster egg sperm penetration assay ( spa ) in predicting human in vitro fertilization ( ivf ) failure and subsequent successful fertilization with zona drilling was assessed . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
145,
148
]
} |
the 30 residues at the nh ( 2 ) termini of dog , cat , and human heavy chains had sequence identities near or exceeding 90 % , in contrast to established interspecies sequence homologies of constant regions of about 60 % . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
59,
64
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
65,
70
]
} |
a sensitive and precise radioimmunoassay for the direct measurement of triiodothyronine ( t ( 3 ) ) in human serum has been designed using sodium salicylate to block t ( 3 ) -tbg binding . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
103,
108
]
} | {
"id": "C3814864",
"name": "tbg",
"pos": [
175,
178
]
} |
molecular analysis of the philadelphia translocation in leukemic cells of cml-patients revealed a consistent translocation of the human c-abl-oncogene from chromosome 9 to the ph1-chromosome , regardless of the cytogenetic subtype . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
130,
135
]
} | {
"id": "C0080279",
"name": "abl-oncogene",
"pos": [
138,
150
]
} |
another human oncogene , c-sis , is located on chromosome 22 , but seems not to play a crucial role in the generation of cml . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
14,
22
]
} |
another human oncogene , c-sis , is located on chromosome 22 , but seems not to play a crucial role in the generation of cml . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0751995",
"name": "c-sis",
"pos": [
25,
30
]
} |
human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0080279",
"name": "abl",
"pos": [
186,
189
]
} |
sequence analysis of one cloned murrs element revealed several possible open reading frames with partial sequence homologies to retroviral gag , pol and env genes . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
128,
138
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
145,
148
]
} |
sequence analysis of one cloned murrs element revealed several possible open reading frames with partial sequence homologies to retroviral gag , pol and env genes . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
128,
138
]
} | {
"id": "C0017343",
"name": "env genes",
"pos": [
153,
162
]
} |
these findings suggest that the activation of cell-division-cycle genes might contribute , like cellular oncogenes , to the phenotype of human malignancies and that , perhaps , new oncogenes could be found by identifying and isolating genes whose expression is dependent on the cell cycle . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
137,
142
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
181,
190
]
} |
to dissect the molecular basis for t-cell recognition of class i major histocompatibility complex antigens , we have examined the ability of human cytotoxic t lymphocytes ( ctl ) to recognize murine l cells transformed with a human class i gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
141,
146
]
} | {
"id": "C0017355",
"name": "class i gene",
"pos": [
232,
244
]
} |
washed human platelets are damaged by two neutral proteases from human leukocytes ( elastase-like protease , elp and chymotrypsin-like protease , clp ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1417838",
"name": "elp",
"pos": [
109,
112
]
} |
the following procedures were associated with high rates of mouse embryo development and human pregnancies following ivf/et : adequate gassing and equilibration of the medium , double-rinsing of pipets and catheters used to handle embryos , use of a hepes-buffered medium for manipulating embryos in the absence of an atmosphere containing 5 % co2 , control of excessive temperature in the vicinity of the embryos , and et using medium containing 50 % patient 's serum . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
117,
120
]
} |
a new experimental model for studying adenosine transport in human erythrocyte ghosts is presented in this work : human erythrocyte ghosts were sealed in the presence of erythro-3 ( 2-hydroxynonyl ) adenine and p1-p5-di ( adenosine ) 5'-pentaphosphate , inhibitors of adenosine deaminase and adenosine kinase , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
217,
219
]
} |
only those hybrids containing human chromosome 18 showed the human-specific hybridization pattern , thereby localizing the human prealbumin gene to this chromosome . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1421224",
"name": "prealbumin gene",
"pos": [
129,
144
]
} |
the most striking feature of these retroviruses is the existence of a long open reading frame located at the 3 ' side of the provirus between the right end of the 3 ' side of env gene and the left end of the long terminal repeat . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
35,
47
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
175,
183
]
} |
the deduced genetic organization most closely resembles that of the aids retrovirus in that there is a novel central region separating pol and env . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
73,
83
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
135,
138
]
} |
the deduced genetic organization most closely resembles that of the aids retrovirus in that there is a novel central region separating pol and env . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
73,
83
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
143,
146
]
} |
immunofluorescent absorption and blocking test revealed that anti-bast specifically reacted with human placenta and cross-reacted with subhuman primate type c rna retrovirus ssv/ssav ( simian sarcoma virus/simian sarcoma associated virus ) , but did not cross-react with atlv ( adult t cell leukaemia virus ) and baev ( baboon endogenous retrovirus ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C0751995",
"name": "ssv",
"pos": [
174,
177
]
} |
sequence homology was found between v-myc , the transforming protein of mc29 virus , and human gastrin and oxytocin on the one hand , and between v-sis , the transforming protein of simian sarcoma virus , and secretin on the other . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C0037207",
"name": "v-sis",
"pos": [
146,
151
]
} |
partial sequence homology between retroviruses of various species in the c-terminal part of the env gene . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
34,
46
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
96,
104
]
} |
however , the chromosomal status was studied in oocytes which remained unfertilised in a human ivf programme . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
95,
98
]
} |
the human beta-2 microglobulin heavy chain-associated determinant was positively detected by the m18 monoclonal antibody . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
31,
42
]
} |
the jf5-j27 transfected cell expressed both heavy and light chains of human class i histocompatibility genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
76,
83
]
} |
results of hybridization with the human dc1 beta probe confirmed that the avn rt1a and nsd rt1b haplotypes were generated by recombinations within the vicinity of the rt1.b : rt1.d regions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
34,
39
]
} | {
"id": "C1415570",
"name": "dc1",
"pos": [
40,
43
]
} |
from a human cdna library constructed from a consanguineous hla-homozygous cell line , akiba ( hla-a24 , bw52 , dr2 , dw12 , dqw1 , and cp63 ) ( cp63 , a new sb type ) , a cdna clone encoding a new hla class ii antigen heavy chain named dq alpha was isolated , and was analyzed by southern blot hybridization and by nucleotide sequence determination . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
219,
230
]
} |
taken together with comparisons of the deduced protein sequences , these data indicate an order of swine greater than human greater than rabbit greater than mouse in the relationship of class i genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
118,
123
]
} | {
"id": "C0017355",
"name": "class i genes",
"pos": [
186,
199
]
} |
on the coding strand , imperfect open reading frames corresponding to gag and pol of the retrovirus genome were observed , whereas many stop codons were present in the region corresponding to env . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
89,
99
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
192,
195
]
} |
utilizing dna transfection analysis with the continuous nih 3t3 cell line as assay cell , we and other have observed that as many as 10-50 % of human haematopoietic tumours contain oncogenes , the vast majority of which are members of the ras proto-oncogene family . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
144,
149
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
181,
190
]
} |
utilizing dna transfection analysis with the continuous nih 3t3 cell line as assay cell , we and other have observed that as many as 10-50 % of human haematopoietic tumours contain oncogenes , the vast majority of which are members of the ras proto-oncogene family . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
144,
149
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
239,
242
]
} |
here , we report the molecular cloning and physical characterization of this human oncogene , whose transforming activity was shown to reside within a human dna sequence of 45 kilobases ( kb ) cloned in a cosmid vector . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
83,
91
]
} |
and ( 2 ) in human developing enamel four forms of traps may arise either from polymorphism at the level of the gene , or by posttranscriptional alternative splicing of amelogenin mrnas , coupled with specific post-secretory proteolytic processing . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
151,
153
]
} |
in idiopathic hypoparathyroidism ( ihp ) , 100 units of human pth ( 1-34 ) increased urinary excretion of nag from 0.029 +/- 0.027 to 0.173 +/- 0.035 u/lgf ( p less than 0.05 ) in two patients before treatment and from 0.025 +/- 0.004 to 0.189 +/- 0.092u/lgf ( p less than 0.02 ) in four patients during treatment with active vitamin d3 ( 1,25 ( oh ) 2d3 or 1 alpha ohd3 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1709111",
"name": "nag",
"pos": [
106,
109
]
} |
human osteosarcomas frequently show loss of alleles on chromosome 17 as well as those on chromosome 13 that harbors the retinoblastoma gene , indicating concerted operation of another tumor-suppressing gene on chromosome 17 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0079427",
"name": "tumor-suppressing gene",
"pos": [
184,
206
]
} |
in contrast , the rate of dna synthesis is rat kidney fibroblasts and human foreskin fibroblasts was significantly stimulated in response to tgf-beta 1 , ldgi , and rtnf-alpha . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
141,
151
]
} |
human oocytes that failed to fertilize in a clinical in vitro fertilization ( ivf ) program were freed from the zona pellucida and reinseminated with spermatozoa from subfertile patients or from fertile donors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
78,
81
]
} |
human ribosomal dna ( rdna ) probe specific for the 3 ' end of the 28s rrna gene was used for detecting standard restriction fragments ' length polymorphism ( rflps ) in the non-transcribed spacer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1704837",
"name": "end",
"pos": [
56,
59
]
} |
comparison of the nucleotide sequence indicated an 85 % sequence similarity to the human tnf-alpha gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C1710304",
"name": "tnf-alpha gene",
"pos": [
89,
103
]
} |
in the former rats , the energy charge ( atp + 1/2adp/atp + adp + amp ) levels of the remnant liver decrease slightly at an early period after partial hepatectomy but could be restored rapidly to normal levels with a concomitant rise of oxidative phosphorylation in remnant liver mitochondria . | partially_excised_anatomy_has_procedure | {
"id": "C0023884",
"name": "liver",
"pos": [
94,
99
]
} | {
"id": "C0193398",
"name": "partial hepatectomy",
"pos": [
143,
162
]
} |
detailed analyses of clinical parameters of renal function and sequential changes in glomerular abnormalities by percutaneous renal biopsy are reported . | partially_excised_anatomy_has_procedure | {
"id": "C0022646",
"name": "renal",
"pos": [
44,
49
]
} | {
"id": "C0372299",
"name": "percutaneous renal biopsy",
"pos": [
113,
138
]
} |
sodium etidronate had a marked effect on pagetoid bone in all cases with reduction of bone turnover demonstrated by the chemistries , scanning , external counting , skin temperature and x-ray diffraction studies of the bone biopsies . | partially_excised_anatomy_has_procedure | {
"id": "C0262950",
"name": "bone",
"pos": [
50,
54
]
} | {
"id": "C0005933",
"name": "of",
"pos": [
212,
214
]
} |
in a case of small-bowel steatorrhea or diarrhea quantitative chemical estimation of the daily output of stool fat is useful , and to this investigation is added a small-bowel radiograph series and , if the radiographic findings are abnormal , small-bowel biopsy . | partially_excised_anatomy_has_procedure | {
"id": "C0021852",
"name": "small-bowel",
"pos": [
13,
24
]
} | {
"id": "C0399943",
"name": "small-bowel biopsy",
"pos": [
244,
262
]
} |
interrelation of left ventricular function and myocardial ultrastructure as assessed by endomyocardial biopsy : comparative study of hypertrophic and congestive cardiomyopathies . | partially_excised_anatomy_has_procedure | {
"id": "C0027061",
"name": "myocardial",
"pos": [
47,
57
]
} | {
"id": "C0189785",
"name": "endomyocardial biopsy",
"pos": [
88,
109
]
} |
we investigated the effects of digital prostatic palpation , cystoscopy , and biopsy of the prostate on the concentrations of serum prostate-specific acid phosphatase ( pap ) measured by radioimmunoassay . | partially_excised_anatomy_has_procedure | {
"id": "C0033572",
"name": "prostatic",
"pos": [
39,
48
]
} | {
"id": "C0194804",
"name": "biopsy of",
"pos": [
78,
87
]
} |
newborn rats and adult animals in which liver cell replication had been induced by partial hepatectomy were injected with 5-bromodeoxyuridine ( budr ) , and were kept without further treatment for the remainder of their life span . | partially_excised_anatomy_has_procedure | {
"id": "C0023884",
"name": "liver",
"pos": [
40,
45
]
} | {
"id": "C0193398",
"name": "partial hepatectomy",
"pos": [
83,
102
]
} |
five cases of renal arteriovenous fistulae are described : four after needle biopsy of the kidney , one due to intrarenal aneurysmal rupture . | partially_excised_anatomy_has_procedure | {
"id": "C0022646",
"name": "renal",
"pos": [
14,
19
]
} | {
"id": "C0558535",
"name": "needle",
"pos": [
70,
76
]
} |
material from hearts known to have had recent myocardial infarction and biopsies of dog hearts subjected to an experimental procedure producing ischaemic injury , were examined by polarising microscopy . | partially_excised_anatomy_has_procedure | {
"id": "C0018787",
"name": "hearts",
"pos": [
14,
20
]
} | {
"id": "C0189784",
"name": "biopsies",
"pos": [
72,
80
]
} |
in spite of the absence of renal symptom a renal biopsy was performed which demonstrated dense deposits disease characterized by the lack of cellular proliferation and highly segmentary deposits similar to those observed in remission after renal transplantation for these disease . | partially_excised_anatomy_has_procedure | {
"id": "C0022646",
"name": "renal",
"pos": [
27,
32
]
} | {
"id": "C0194073",
"name": "renal biopsy",
"pos": [
43,
55
]
} |
the in vitro neocortical brain slice technique was used to study electrophysiological properties of neurons from brain biopsies in 10 patients undergoing neurosurgical treatment for a variety of conditions , including focal epilepsy . | partially_excised_anatomy_has_procedure | {
"id": "C0006104",
"name": "brain",
"pos": [
25,
30
]
} | {
"id": "C0740294",
"name": "brain biopsies",
"pos": [
113,
127
]
} |
the contralateral breast was available for follow-up in the remaining 84 cases , including 33 patients who underwent contralateral biopsy and 51 others who did not have a biopsy of the opposite breast at the time of initial treatment . | partially_excised_anatomy_has_procedure | {
"id": "C0006141",
"name": "breast",
"pos": [
18,
24
]
} | {
"id": "C0405352",
"name": "biopsy of",
"pos": [
171,
180
]
} |
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