text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
most of the histidine in human hmw-kininogen was recovered in the kinin-free protein , and the light chain of kinin-free protein was found to be rich in histidine compared with the heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
181,
192
]
} |
thus , the human beta- and gamma-globin genes in these cells are differentially regulated apparently by a positive regulatory factor ( s ) specific for individual globin genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C3825351",
"name": "globin",
"pos": [
163,
169
]
} |
fragmentation of the human transplantation antigen heavy chain by limited proteolysis , acid cleavage , and cyanogen bromide treatment . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
51,
62
]
} |
as part of the strategy for determining the covalent structure of a human iga1 molecule ( bur ) , a tryptic digest was prepared of the reduced and carboxymethylated alpha1 heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
68,
73
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
172,
183
]
} |
polystyrene beads coated with igg prepared from a human serum containing antibodies to hbeag ( anti-hbe ) and anti-hbe igg labelled with 125i-p-hydroxyphenylpropionic acid n-hydroxysuccinimide ester were used in the test . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C1415484",
"name": "hbe",
"pos": [
115,
118
]
} |
the strong cross-reaction between rabbit and human beta2-microglobulins , as detected by goat antisera , has permitted the development of heterologous radioimmunoassays to detect homologues of beta2-microglobulin ( beta2mu ) in the sera of various vertebrate species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
215,
220
]
} |
the assay based on the inhibition of the binding reaction between goat anti-rabbit beta2 mu and human beta2 mu divided the sera examined into two groups , one giving high levels of inhibition ( approximately 80 % ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
96,
101
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
102,
107
]
} |
when the same group of sera was tested using the assay based on the inhibition of binding of rabbit beta2 mu to goat anti-human beta2 mu , a wide range of maximal levels of inhibition was observed , with clustering of phylogenetically related species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
122,
127
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
128,
133
]
} |
the acetylation of procainamide and sulfadimidine has been measured simultaneously in plasma and urine in 20 healthy human volunteers by a specific g.l.c . method , after single and multiple oral dral doses of procainamide retard tablets . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C1333547",
"name": "dral",
"pos": [
196,
200
]
} |
assignment of a gene for human mitochondrial isocitrate dehydrogenase ( icd-m , ec 1.1.1.41 ) to chromosome 15 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C2827560",
"name": "icd-m",
"pos": [
72,
77
]
} |
two monoclonal antibodies , anti-ti1a and anti-ti1b , were shown to define the clonally unique surface receptor on ct8iii , a human cytolytic t lymphocyte specific for a class i major histocompatibility gene product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
126,
131
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
170,
177
]
} |
we are currently examining other dna samples from both human tumor-derived cell lines and primary human tumors to determine if this assay will detect and identify additional oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
174,
183
]
} |
the short wavelength color mechanism in the human visual system can distinguish gratings from uniform fields of the same average radiance at spatial frequencies that are twice as high as the highest at which it can resolve bars in the grating . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1707156",
"name": "bars",
"pos": [
223,
227
]
} |
three cell surface protein-specific methods were used to radiolabel the major glycoproteins of four human bladder carcinoma cell lines : the well-differentiated lines rt112 and tr4 and more anaplastic lines t24 and ej . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
100,
105
]
} | {
"id": "C1417830",
"name": "tr4",
"pos": [
177,
180
]
} |
four mouse monoclonal antibodies to human b cell surface determinants previously described as being directed against ia like ( mhc class ii ) antigens , have been shown to precipitate ia alpha and beta chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
127,
139
]
} |
our animal data suggest that the human syndrome results from exposure in utero to agents like win 18,446 , which damage the fetus during a critical period of organogenesis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C3538717",
"name": "win",
"pos": [
94,
97
]
} |
b2-menezo-medium supplemented by 15 % human serum seemed best suited for human ivf because of its simplicity and readiness for use . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
79,
82
]
} |
antigenic analogues of all known epidemic human viruses ( h1 , h2 and h3 ) have been isolated from natural sources in the ussr . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
63,
65
]
} |
we now report that early human pre-b cells , epstein -- barr virus transformed pre-b cells , and pre-b cell hybrid analogues , produce c mu without the normally associated heavy-chain variable ( vh ) region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
172,
183
]
} |
these levels of c-fos expression in human amniotic and chorionic cells are close to the level of v-fos expression that results in the induction of osteosarcomas in mice and transformation of fibroblasts in vitro . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C0087140",
"name": "v-fos",
"pos": [
97,
102
]
} |
transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
46,
58
]
} |
in the case of the human bladder carcinoma cell lines ej and t24 , this approach has led to the molecular cloning of a transforming gene which is closely related to the rat-derived harvey sarcoma virus oncogene , v-ha-ras . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0029016",
"name": "transforming gene",
"pos": [
119,
136
]
} |
in the case of the human bladder carcinoma cell lines ej and t24 , this approach has led to the molecular cloning of a transforming gene which is closely related to the rat-derived harvey sarcoma virus oncogene , v-ha-ras . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0079471",
"name": "harvey sarcoma virus oncogene",
"pos": [
181,
210
]
} |
in the case of the human bladder carcinoma cell lines ej and t24 , this approach has led to the molecular cloning of a transforming gene which is closely related to the rat-derived harvey sarcoma virus oncogene , v-ha-ras . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
218,
221
]
} |
a family of human transforming genes , previously shown to share homology with the ras family of viral oncogenes , maps to three different human chromosomes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C0034678",
"name": "ras family",
"pos": [
83,
93
]
} |
sequence comparisons between pb4d5 , a cloned germ-line precursor of the pb4d5 joining ( j ) region , and published b4 amino acid sequences reveal a peculiar feature of rabbit kappa v-j recombination in which this system resembles mouse and human heavy chain recombination more than any known kappa system . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
241,
246
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
247,
258
]
} |
here we show that human cellular sequences ( c-abl ) homologous to the transforming sequences of the mouse abelson leukemia virus ( v-abl ) are amplified some 4- to 8-fold in k-562 , a philadelphia chromosome-positive cell line derived from a patient with chronic myelogenous leukemia in blast crisis . | organism_has_gene | {
"id": "C0000742",
"name": "abelson",
"pos": [
107,
114
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
132,
137
]
} |
restriction analysis of k-562 and other human dna samples reveals a significant rearrangements of the c-abl sequences in this cell line . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
104,
107
]
} |
differential expression of the normal and of the translocated human c-myc oncogenes in b cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C0086661",
"name": "myc",
"pos": [
70,
73
]
} |
transforming genes of human hematopoietic tumors : frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
73,
76
]
} |
a primary human acute myelogenous leukemia , a chronic myelogenous leukemia cell line , and cell lines derived from three independent acute lymphocytic leukemias demonstrated oncogenes capable of conferring the transformed phenotype to nih 3t3 cells through serial cycles of transfection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
175,
184
]
} |
these results indicated that visna virus codes for the largest non-glycosylated env-related precursor among all of the retroviruses and therefore probably contains the largest env gene . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
119,
131
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
176,
184
]
} |
blot hybridization analysis indicated that nih 3t3 mouse bladder transformed by high molecular weight dnas of a human bladder and a human lung carcinoma cell line contained new sequences homologous , respectively , to the transforming genes of harvey ( rash ) and kirsten ( rask ) sarcoma viruses . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
112,
117
]
} | {
"id": "C0029016",
"name": "transforming genes",
"pos": [
222,
240
]
} |
human erythrocyte ghost membranes have been investigated using two intramolecular excimer probes , di ( 1-pyrenyl ) propane and di ( 1-pyrenylmethyl ) ether . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
128,
130
]
} |
the oncogenic sequence was isolated initially from a lambda phage genomic library made from dna of a transfected mouse cell carrying the human oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
137,
142
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
143,
151
]
} |
haemophilus influenzae is one of five bacterial species known to produce iga proteases , enzymes that specifically cleave the human iga1 heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
126,
131
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
137,
148
]
} |
these data suggest an active role for human pmns in the genesis of and defense against virus infections and indicate areas for further investigation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
56,
63
]
} |
we investigated serial expressions of eight proto-oncogenes during in-vitro differentiation of normal human burst-forming unit , erythroid ( bfu-e ) , and found that c-myc and c-fos are expressed in progenies of bfu-e . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
166,
171
]
} |
cells cultured from human atheroma contained mrnas for the pdgf a chain ( 16 of 17 isolates ) but none ( of 13 ) that encoded pdgf b chain ( the c-sis proto-oncogene product ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1335200",
"name": "pdgf a chain",
"pos": [
59,
71
]
} |
cells cultured from human atheroma contained mrnas for the pdgf a chain ( 16 of 17 isolates ) but none ( of 13 ) that encoded pdgf b chain ( the c-sis proto-oncogene product ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C0751995",
"name": "c-sis proto-oncogene",
"pos": [
145,
165
]
} |
samples of 37 fresh human ovarian tumor biopsies were screened to detect proto-oncogene amplification and ras mutations . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
106,
109
]
} |
the human ets-1 and ets-2 gene products were identified by means of antibodies directed against the ets-1 and ets-2 encoded products . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0812201",
"name": "ets-1",
"pos": [
100,
105
]
} |
by infecting an il-3 dependent myeloid cell line , fdc-p1 , with a-mulv containing temperature sensitive tyrosine kinase mutants of the v-abl oncogene , cell lines with temperature sensitive il-3 independence phenotype were established . | organism_has_gene | {
"id": "C0000742",
"name": "a-mulv",
"pos": [
65,
71
]
} | {
"id": "C0080279",
"name": "v-abl oncogene",
"pos": [
136,
150
]
} |
these results demonstrate that the maintenance of a-mulv induced il-3 independence requires the continuous function of the v-abl oncogene . | organism_has_gene | {
"id": "C0000742",
"name": "a-mulv",
"pos": [
50,
56
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
123,
128
]
} |
here , we have examined the human homolog of int-2 in 110 primary breast cancer dnas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1708016",
"name": "int-2",
"pos": [
45,
50
]
} |
reverse transcriptase of the avian sarcoma and leukosis retroviruses is a heterodimer composed of a 63-kda alpha and a 95-kda beta polypeptide chain , both of which are encoded in the pol gene and are produced by proteolytic processing of a larger precursor . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
56,
68
]
} | {
"id": "C0017360",
"name": "pol gene",
"pos": [
184,
192
]
} |
antibody against human placental mcm was used to screen human placenta and liver cdna expression libraries for mcm cdna clones . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
17,
22
]
} | {
"id": "C1709402",
"name": "mcm",
"pos": [
111,
114
]
} |
the effect of transfection of nih 3t3 cells by the human ras ( c-ha-ras-1 ) oncogene on uptake , interconversion , and excretion of polyamines was studied . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
51,
56
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
68,
71
]
} |
the effect of transfection of nih 3t3 cells by the human ras ( c-ha-ras-1 ) oncogene on uptake , interconversion , and excretion of polyamines was studied . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
51,
56
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
76,
84
]
} |
in vitro cell culture studies using human granulosa-luteal cells isolated from women undergoing ovarian stimulation for ivf have shown no affect on t , delta 4a , or dht secretion in the presence of clinically therapeutic levels of spironolactone ( 0-10 ( -6 ) m ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
120,
123
]
} |
expression of the human apolipoprotein e gene is regulated by multiple positive and negative elements . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1412481",
"name": "apolipoprotein e gene",
"pos": [
24,
45
]
} |
we examined which regions of the human apoe gene contributed to its tissue-specific expression using hepg2 and hela cells as examples of expressing and nonexpressing tissues , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C1412481",
"name": "apoe gene",
"pos": [
39,
48
]
} |
human ril-1 alpha and -1 beta are shown to increase significantly the cfu-culture activity in the spleen as well as at other sites after i.v . or i.p . administration . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
6,
9
]
} |
the sequence and timing of administration of human ril-1 is critical for the protection or rescue of animals receiving dna-damaging agents ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
51,
54
]
} |
human and murine class ii genes of the mhc show a striking homology 50 to 120 bp upstream of the transcription start site . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0017349",
"name": "class ii genes",
"pos": [
17,
31
]
} |
finally , several other murine and human class i mhc variants have similar alterations at amino acid position 152 which result in altered biological functions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0017355",
"name": "class i mhc",
"pos": [
41,
52
]
} |
transformation of diploid human fibroblasts by transfection with the v-sis , pdgf2/c-sis , or t24 h-ras genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0037207",
"name": "v-sis",
"pos": [
69,
74
]
} |
transformation of diploid human fibroblasts by transfection with the v-sis , pdgf2/c-sis , or t24 h-ras genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0751995",
"name": "pdgf2",
"pos": [
77,
82
]
} |
activated human c-ha-ras and n-ras genes co-operated differentially with different e1as for her transformation but were ineffective without e1a . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
31,
34
]
} |
activated human c-ha-ras and n-ras genes co-operated differentially with different e1as for her transformation but were ineffective without e1a . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0027260",
"name": "n-ras genes",
"pos": [
29,
40
]
} |
a hybrid gene was constructed by inserting the ed-b region into the third exon of the human alpha 1-globin gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C2697529",
"name": "alpha 1-globin gene",
"pos": [
92,
111
]
} |
intact , human hras sequences were observed in 2 of the 11 tumor groups , whereas no hybridization was detected when human kras or nras probes were used . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C0027260",
"name": "nras",
"pos": [
131,
135
]
} |
slow-migrating ras p21 proteins , consistent with codon 12 mutations , were observed i in the same two nih 3t3 tumor cell groups that contained the human hras bands . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
148,
153
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
154,
158
]
} |
genomic dna from one of these two human anchorage-independent cell populations ( clone 21a ) was used to enzymatically amplify a portion of exon 1 of the hras gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
34,
39
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
154,
158
]
} |
southern blot hybridizations of rodent x owl monkey hybrid dnas with human cdna probes allowed the mapping of the mos and myc gene loci to owl monkey chromosome 16 of karyotype vi ( 2n = 49 male/50 female ) and to the homologous chromosome 15 of karyotype v ( 2n = 46 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
69,
74
]
} | {
"id": "C0026902",
"name": "myc gene",
"pos": [
122,
130
]
} |
cloning and sequencing of the human type ii insulin-like growth factor ( igf ) receptor cdna revealed an 80 % deduced amino acid sequence homology with the bovine cation-independent mannose 6-phosphate ( man-6-p ) receptor , suggesting identity of the two receptors ( morgan , d. o. , edman , j. c. , standring , d. n. , fried , v. a. , smith , m. c. , roth , r. a. , and rutter , w. j . ( 1987 ) nature 329 , 301-307 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1334090",
"name": "cation-independent mannose 6-phosphate",
"pos": [
163,
201
]
} |
however , human ril-2 , a strong inducer of t cell proliferation , did not stimulate n-alpha-benzyloxycarbonyl-l-lysine thiobenzyl ester-esterase secretion by itself , nor did it influence the secretion mediated by ag . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
16,
19
]
} |
studies were performed to characterize the toxic effects of human ril-2 in mice and to examine the mechanism of toxicity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
66,
69
]
} |
the most commonly found transforming genes isolated from human tumor cells by dna transfection assay are the ras gene family ( c-h-ras , c-k-ras and n-ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1335597",
"name": "ras gene family",
"pos": [
109,
124
]
} |
the most commonly found transforming genes isolated from human tumor cells by dna transfection assay are the ras gene family ( c-h-ras , c-k-ras and n-ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
129,
134
]
} |
the most commonly found transforming genes isolated from human tumor cells by dna transfection assay are the ras gene family ( c-h-ras , c-k-ras and n-ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C0809246",
"name": "n-ras",
"pos": [
149,
154
]
} |
the gene for the catecholamine biosynthetic enzyme , tyrosine hydroxylase ( th ) , has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin ( ins ) and for the oncogene harvey ras 1 ( hras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C0034678",
"name": "oncogene",
"pos": [
199,
207
]
} |
the gene for the catecholamine biosynthetic enzyme , tyrosine hydroxylase ( th ) , has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin ( ins ) and for the oncogene harvey ras 1 ( hras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
223,
227
]
} |
a full-length cdna for the human multidrug resistance gene 1 ( mdr1 ) has been inserted into a retroviral vector containing a murine harvey sarcoma virus from which the viral oncogene was deleted . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C1704939",
"name": "multidrug resistance gene 1",
"pos": [
33,
60
]
} |
infected cells became resistant to colchicine , vinblastine , doxorubicin , vp16 ( etoposide ) , and puromycin , but not cisplatin , indicating that the presence of the human mdr1 gene is sufficient to cause multidrug resistance . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
169,
174
]
} | {
"id": "C1704939",
"name": "mdr1",
"pos": [
175,
179
]
} |
antigens isolated by hydroxyapatite chromatography from human sciatic nerve ( sn1 protein ) and from 8 m urea extracts of chicken brain were selectively localized by immunofluorescence to neurofibrils in rat and chicken cns . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1442750",
"name": "sn1",
"pos": [
78,
81
]
} |
potentiation of itch and flare responses in human skin by prostaglandins e2 and h2 and a prostaglandin endoperoxide analog . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
80,
82
]
} |
precipitating antibodies directed toward human f.viii/wf were found in the plasma of four out of 17 multitransfused patients with severe , homozygous-like vwd . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
41,
46
]
} | {
"id": "C1710605",
"name": "vwd",
"pos": [
155,
158
]
} |
although an etiological role of c-type rna virus has not yet been demonstrated in human cancer , studies of the interaction of viral and host-cell genomes in mice and other species , and the visualization of c-type virus in human tumors have provided good reasons for suspecting the presence in man of oncogenic genes ( oncogenes ) homologous to those of the c-type viral genomes , which are well studied in mice , hamsters , cats , rats , and chickens . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
82,
87
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
320,
329
]
} |
to determine whether one of these pathways is more important than the other , or whether one pathway is physiologically relevant , we employed normal nih-3t3 cells ( 3t3 cells ) and nih-3t3 cells expressing the ej human bladder ras oncogene ( ej cells ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
214,
219
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
228,
240
]
} |
thus human activated n-ras gene may not be sufficient to confer metastatic behavior in nude mice and the metastatic ability of human melanoma dna transfected cells may be due to , among other possibilities , expression of other gene sequences from melanoma dna co-transfected with the n-ras oncogene , or to specific activated murine sequences switched on during the initial process of transfection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
5,
10
]
} | {
"id": "C0027260",
"name": "n-ras oncogene",
"pos": [
285,
299
]
} |
the methylation pattern of the human hla-dr alpha gene was analyzed in normal breast tissues , breast primary tumors and lymphonodal metastases isolated from patients carrying breast carcinomas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C1415575",
"name": "hla-dr alpha gene",
"pos": [
37,
54
]
} |
it is suggested that hypomethylation of the human hla-dr alpha gene could be proposed as a molecular marker of malignant breast tumors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1415575",
"name": "hla-dr alpha gene",
"pos": [
50,
67
]
} |
a rapid chemosensitivity assay was developed , employing the human continuous leukemic cell lines hl 60 , k 562 , flg 29.1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0919509",
"name": "flg",
"pos": [
114,
117
]
} |
promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1366557",
"name": "transforming growth factor-beta 1",
"pos": [
85,
118
]
} |
the chloramphenicol acetyltransferase activity of the upstream human tgf-beta 1 promoter-chloramphenicol acetyltransferase gene is increased 8- to 10-fold by treatment of cells with tgf-beta 1 , whereas that of the second promoter is increased approximately 3- to 4-fold . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
182,
192
]
} |
seven distinct factors present in nuclear extracts from a-549 cells interact with the sequences between -454 and -323 , strongly supporting the involvement of sequence-specific transcription factors in the transcriptional autoactivation of the human tgf-beta 1 gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
244,
249
]
} | {
"id": "C1366557",
"name": "tgf-beta 1 gene",
"pos": [
250,
265
]
} |
a novel fusion gene has been created in which the expression of a dominant selectable marker , the human multidrug resistance gene , is directly linked to the expression of human adenosine deaminase cdna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
99,
104
]
} | {
"id": "C0376623",
"name": "multidrug resistance gene",
"pos": [
105,
130
]
} |
the data indicate that the human multidrug resistance gene may be used as a dominant selectable marker to introduce other genes in the form of gene fusions into cultured cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0376623",
"name": "multidrug resistance gene",
"pos": [
33,
58
]
} |
second , by using the human leukemia cell line hel as a model for primitive megakaryocytic cells , we studied the effect of pf4 on cell doubling time , on the expression of both growth-regulated ( h3 , p53 , c-myc , and c-myb ) , and non-growth-regulated ( beta 2-microglobulin ) genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
208,
213
]
} |
increases in levels of procollagenase messenger rna in cultured fibroblasts induced by human recombinant interleukin 1 beta or serum follow c-jun expression and are dependent on new protein synthesis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
87,
92
]
} | {
"id": "C0162508",
"name": "c-jun",
"pos": [
140,
145
]
} |
a 19-kda human erythrocyte molecule h19 is involved in rosettes , present on nucleated cells , and required for t cell activation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C1333887",
"name": "h19",
"pos": [
36,
39
]
} |
we have investigated the effects of lps , human rtnf ( hrtnf ) and human ril-1 beta ( hril-1 beta ) pretreatment on the intensity of antibody-mediated injury in vivo by using a passive model of anti-glomerular basement membrane ( gbm ) antibody-mediated nephritis in rats . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
87,
90
]
} |
the lowest effective dose of lps was 0.025 microgram while those for hrtnf and hril-1 beta were 0.4 microgram and 0.5 microgram , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 beta",
"pos": [
79,
90
]
} | {
"id": "C1335621",
"name": "hril-1 beta",
"pos": [
79,
90
]
} |
lps pretreatment appeared to be more effective in causing glomerular capillary thrombi than hrtnf or hril-1 beta and this was reflected in the correlations between albuminuria and the proportion of glomeruli with capillary thrombi . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 beta",
"pos": [
101,
112
]
} | {
"id": "C1335621",
"name": "hril-1 beta",
"pos": [
101,
112
]
} |
this relation was linear for all three pretreatments but the slope was appreciably greater for rats pretreated with lps ( 0.37 ) when compared with results from rats given either hrtnf ( 0.22 ) or hril-1 beta ( 0.29 ) . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 beta",
"pos": [
197,
208
]
} | {
"id": "C1335621",
"name": "hril-1 beta",
"pos": [
197,
208
]
} |
the synergism of hrtnf with hril-1 beta was also demonstrated by the effective doses needed to induce albuminuria which was evident in rats treated with 0.05 microgram of il-1 beta and 0.4 microgram of tnf . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 beta",
"pos": [
28,
39
]
} | {
"id": "C1335621",
"name": "hril-1 beta",
"pos": [
28,
39
]
} |
human ril-1 alpha significantly enhanced splenic plaque-forming cells ( pfc ) to srbc in vitro and in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
6,
9
]
} |
lack of correlation of immunosuppressive activity secreted by human in vitro fertilized ( ivf ) ova with successful pregnancy . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
90,
93
]
} |
the high rate of implantation failure in humans following in vitro fertilization ( ivf ) has been attributed to a lack of production of immunosuppressive factors by cleaved embryos , rendering them vulnerable to maternal immune attack just before or around implantation . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
41,
47
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
83,
86
]
} |
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