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the hemizona assay ( hza ) : a predictor of human sperm fertilizing potential in in vitro fertilization ( ivf ) treatment .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 106, 109 ] }
immunosuppressive activity in human in vitro fertilization ( ivf ) culture supernatants and prediction of the outcome of embryo transfer : a multicenter trial .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 30, 35 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 61, 64 ] }
in a set of four increasingly multidrug-resistant variants of sw-1573 human lung tumor cells , the phi ( i.e. , steady-state cytosolic ph ) increased up to 0.44 u as a function of the level of doxorubicin resistance .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 70, 75 ] }
{ "id": "C0376622", "name": "doxorubicin resistance", "pos": [ 193, 215 ] }
analogous mutations in human h-ras also dominantly inhibited ras function when expressed in yeast cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 29, 34 ] }
analogous mutations in human h-ras also dominantly inhibited ras function when expressed in yeast cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 61, 64 ] }
human platelet-derived growth factor ( pdgf ) is composed of two polypeptide chains , pdgf-1 and pdgf-2 , the human homolog of the v-sis oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1705597", "name": "homolog", "pos": [ 116, 123 ] }
human platelet-derived growth factor ( pdgf ) is composed of two polypeptide chains , pdgf-1 and pdgf-2 , the human homolog of the v-sis oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 137, 145 ] }
we have identified a 24-kilodalton protein that is the product of the human bcl-2 gene , implicated as an oncogene because of its presence at the site of t ( 14 ; 18 ) translocation breakpoints .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 70, 75 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 106, 114 ] }
we describe here a protein found in the yeast saccharomyces cerevisiae which possesses dna-binding properties that are virtually identical to those of human mltf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 151, 156 ] }
{ "id": "C1421376", "name": "mltf", "pos": [ 157, 161 ] }
respiratory-deficient mutants ( rho- cells ) of saccharomyces cerevisiae produced about 10 times as much human ( h- ) lysozyme as did wild-type strains ( rho+ cells ) when the gal10 promoter was used in an expression plasmid with the h-lysozyme gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 105, 110 ] }
{ "id": "C1707136", "name": "gal10", "pos": [ 176, 181 ] }
the effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma pc12 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 24, 29 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 30, 33 ] }
the effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma pc12 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 24, 29 ] }
{ "id": "C0086661", "name": "myc oncogenes", "pos": [ 38, 51 ] }
using either human placental microsomal 5-deiodinase as enzyme ( 5-di ) and thyroxine as substrate or rat liver ( rl ) microsomal 5'-deiodinase ( 5'di ) as enzyme and reverse [ ( 3'- or 5'- ) -125i ] triiodo-l-thyronine ( [ 125i ] rt3 ) as substrate , activation of 5'-di in the presence of nadph was observed using either human placental or rat liver cytosolic components , but there was no activation of 5-di .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 13, 18 ] }
{ "id": "C3538902", "name": "di", "pos": [ 408, 410 ] }
thus , human placental and rat liver cytosolic components are interchangeable in activating hepatic 5'-di in the presence of nadph .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 7, 12 ] }
{ "id": "C3538902", "name": "di", "pos": [ 103, 105 ] }
however , if an endogenous cofactor system involved in the activation of human placental 5-di exists , it probably differs from the activator of liver 5'-di .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 73, 78 ] }
{ "id": "C3538902", "name": "di", "pos": [ 154, 156 ] }
glycopeptides derived from nih 3t3 fibroblasts and these cells transformed by transfection with human dna containing oncogene h-ras were analyzed by 500-mhz 1h-nmr spectroscopy and binding to immobilized lectins .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 96, 101 ] }
{ "id": "C1616867", "name": "oncogene h-ras", "pos": [ 117, 131 ] }
hemagglutination of pronase-treated human type b erythrocytes by the ltc-b was inhibited by methyl-alpha-d-galactopyranoside , galactose , melibiose , hog a + h , asialo-bovine salivary mucin and asialo-thyroglobulin among mono- , di- and polysaccharides and glycoproteins used as inhibitors .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C3538902", "name": "di", "pos": [ 231, 233 ] }
using in situ hybridization , we have localized the human putative oncogene gli to chromosome subbands 12q13.3-14.1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 52, 57 ] }
{ "id": "C0812304", "name": "oncogene gli", "pos": [ 67, 79 ] }
since the human d4s43 locus is less than 1 cm proximal to hd near the telomere of chromosome 4 , the murine counterpart of the hd gene might lie between hx and emv-1 or d4s43h .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 10, 15 ] }
{ "id": "C1415504", "name": "hd gene", "pos": [ 127, 134 ] }
using monoclonal antibodies ( moabs ) against mam antigens ( human milk fat globule membrane ) , we achieved selective demonstration of the secretory canaliculi ( mam-6 moabs ) or the inner layer cells of eccrine duct ( mam-3 moabs ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 61, 66 ] }
{ "id": "C2987159", "name": "mam-3", "pos": [ 220, 225 ] }
this work was performed using rabbit oocytes as well as human oocytes and one-cell embryos from the routine ivf programme .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 56, 61 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 108, 111 ] }
transcriptional and post-transcriptional regulation of human mhc class ii genes require the synthesis of short-lived proteins .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C0017349", "name": "mhc class ii genes", "pos": [ 61, 79 ] }
we have studied the stability of protein factors which control the intracellular levels of human mhc class ii genes in b cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 91, 96 ] }
{ "id": "C0017349", "name": "mhc class ii genes", "pos": [ 97, 115 ] }
we report that human mhc class ii gene transcription and mrna stability require the synthesis of short-lived proteins which undergo rapid intracellular turnover .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 21, 33 ] }
likewise , comparison of mrna turnover rate in cells treated with actinomycin d , an inhibitor of rna synthesis , and in cycloheximide-treated cells shows that a post-transcriptional factor is required to stabilized human mhc class ii mrna by a factor of 8- to 10-fold in b cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 216, 221 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 222, 234 ] }
comparison of the fla class i coding sequence with other class i genes from other species revealed that the domestic cat genes display 81 to 82 % sequence identity with human , and 73 to 79 % sequence identity with mouse class i genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 169, 174 ] }
{ "id": "C0017355", "name": "class i genes", "pos": [ 221, 234 ] }
feline and human class i genes have similar sequences and protein structures , with three ( alpha ) extracellular domains , one transmembrane domain , and one cytoplasmic domain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C0017355", "name": "class i genes", "pos": [ 17, 30 ] }
induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 dna and viral harvey ras .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 13, 18 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 129, 132 ] }
we report the genomic organization and dna sequence of the human homologue of int-2 , a proto-oncogene implicated in virally induced mammary tumours in the mouse , and expressed at specific sites and times during embryogenesis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 78, 83 ] }
the data suggest that human int-2 may also function in embryonic lineages but that its transcription may be less complex than in the mouse .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 22, 27 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 28, 33 ] }
in this study , we demonstrate that expression of a transfected , oncogenic , human h-ras gene in c3h10t1/2-derived myoblasts has dramatic , yet varied , effects on skeletal myogenesis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 78, 83 ] }
{ "id": "C0079471", "name": "h-ras gene", "pos": [ 84, 94 ] }
in this report we assigned to chromosome 10q the human oncogene ptc frequently associated with the papillary type of thyroid carcinoma .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 55, 63 ] }
mouse embryo-derived balb/3t3 cells were transfected with the mutated form of the human c-ha-ras-1 ( ej-ras ) along with a genetic marker ( neo gene ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 82, 87 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 104, 107 ] }
in this construct , the human c-myc proto-oncogene expression is driven by the 5 ' flanking sequences ( including promoter ) of the class i h-2kb gene , which have previously been shown to direct the expression of a marker gene , the human growth hormone ( hgh ) , in most tissues of h-2k/hgh transgenic mice .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 24, 29 ] }
{ "id": "C0017355", "name": "class i", "pos": [ 132, 139 ] }
none of nine human p53 constructs was capable of cooperating with an activated ras oncogene to transform primary cells under conditions where a mouse clone , pltrp53cg , could do so efficiently .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 13, 18 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 79, 91 ] }
as an initial step toward elucidating the regulatory regions involved in control of tf gene expression , we have established the organization of the 12.4 kbp human tf gene and its complete dna sequence .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 158, 163 ] }
{ "id": "C1705607", "name": "tf gene", "pos": [ 164, 171 ] }
diabetes induced in male transgenic mice by expression of human h-ras oncoprotein in pancreatic beta cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 58, 63 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 64, 69 ] }
this study demonstrates , however , that the transfection of human or murine class i genes into k562 cells leads to the cell surface expression of the transfected mhc gene product in all situations , even when several kilobases of 5 ' flanking sequence were included in the transfected genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 61, 66 ] }
{ "id": "C0017355", "name": "class i genes", "pos": [ 77, 90 ] }
as demonstrated for transformed human fibroblasts , the morphology of neu- , ras- , src- and sis-transformed mouse fibroblasts became more normal after glucocorticoid treatment .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 77, 80 ] }
however , supertransformation of one of the bpv-1-transformants by the human ej-harvey ras-1 oncogene , known to sensitize fr3t3 and nih3t3 cells , correlated with an increase in susceptibility to mvmp .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 71, 76 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 87, 90 ] }
we then demonstrated that , during expression in infected cells , splicing fuses the first six amino acids of the retroviral gene gag to the body of the v-erb-b protein .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 114, 124 ] }
{ "id": "C0017346", "name": "gene", "pos": [ 125, 129 ] }
18 ) chromosomal translocation of human follicular lymphoma recombines the bcl-2 gene from chromosome 18 with the immunoglobulin heavy chain joining region .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 129, 140 ] }
we have sought the presence of such activating mutations in a series of 100 cases of human breast cancer by polymerase chain reaction amplification and sequence-specific oligonucleotide hybridization , and also by a designed restriction fragment length polymorphism strategy in cases with southern blot evidence of c-erbb-2 amplification .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 85, 90 ] }
{ "id": "C0243036", "name": "erbb", "pos": [ 317, 321 ] }
a bacterial expression vector containing a segment of the v-abl gene from abelson murine leukemia virus ( a-mulv ) was constructed such that the gag region of v-abl was replaced by a sequence encoding the igg-binding domain of the s. aureus protein a. pabl hp , a fusion protein encoded by this vector was rapidly purified to near homogeneity by affinity chromatography on igg-affigel and mono q fplc .
organism_has_gene
{ "id": "C0000742", "name": "abelson murine leukemia virus", "pos": [ 74, 103 ] }
{ "id": "C0080279", "name": "v-abl", "pos": [ 159, 164 ] }
human c-fps/fes when expressed at sufficiently high levels in nih 3t3 cells can induce cellular transformation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1708010", "name": "fps", "pos": [ 8, 11 ] }
in total cellular rna , tgf-alpha mrna is not detectable by northern analysis at 6 days when there is increased expression of the human homeotic genes hu-1 ( hox 2.1 ) and hu-2 ( hox 2.2 ) , known markers of ra response in nt2/d1 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 130, 135 ] }
{ "id": "C0017347", "name": "homeotic genes", "pos": [ 136, 150 ] }
in total cellular rna , tgf-alpha mrna is not detectable by northern analysis at 6 days when there is increased expression of the human homeotic genes hu-1 ( hox 2.1 ) and hu-2 ( hox 2.2 ) , known markers of ra response in nt2/d1 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 130, 135 ] }
{ "id": "C1415652", "name": "hox", "pos": [ 179, 182 ] }
in total cellular rna , tgf-alpha mrna is not detectable by northern analysis at 6 days when there is increased expression of the human homeotic genes hu-1 ( hox 2.1 ) and hu-2 ( hox 2.2 ) , known markers of ra response in nt2/d1 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 130, 135 ] }
{ "id": "C3540565", "name": "hox 2.2", "pos": [ 179, 186 ] }
the human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1708015", "name": "basic fibroblast growth factor gene", "pos": [ 10, 45 ] }
in addition to being useful for the screening of human tumor dnas , shok cells will be useful for the isolation of oncogenes from murine tumors because of their hamster origin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 115, 124 ] }
it is difficult to extend these results directly to mammalian embryos , but we have shown that the products of the murine int-2 gene and of the human k-fgf genes are active as mesoderm inducing factors .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 144, 149 ] }
{ "id": "C1705579", "name": "k-fgf genes", "pos": [ 150, 161 ] }
characterization of a putative promoter region of the human poly ( adp-ribose ) polymerase gene : structural similarity to that of the dna polymerase beta gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 54, 59 ] }
{ "id": "C1709384", "name": "poly ( adp-ribose", "pos": [ 60, 77 ] }
in the present study , human and murine class i and class ii gene probes were used to analyze the leukocyte antigen ( cyla ) system of unrelated and related cynomolgus monkeys .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C0017349", "name": "class ii gene", "pos": [ 52, 65 ] }
as in the human mhc , the class ii beta genes are more polymorphic than class ii alpha genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 10, 15 ] }
{ "id": "C0017349", "name": "class ii", "pos": [ 72, 80 ] }
chromosome mapping of the human ras-related rap1a , rap1b , and rap2 genes to chromosomes 1p12 -- -- p13 , 12q14 , and 13q34 , respectively .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 26, 31 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 32, 35 ] }
three human cdnas encoding new ras-related cdnas , designated rap1a , rap1b , and rap2 , have been isolated previously .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 6, 11 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 31, 34 ] }
the marker d17s5 , mapping to the short arm of chromosome 17 , was recently reported by us and others to undergo frequent heterozygous deletion in human primary breast carcinomas , implicating the presence of a tumor suppressor gene in this region .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 147, 152 ] }
{ "id": "C0079427", "name": "tumor suppressor gene", "pos": [ 211, 232 ] }
the human homeobox gene hox7 maps to chromosome 4p16.1 and may be implicated in wolf-hirschhorn syndrome .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0017347", "name": "homeobox gene", "pos": [ 10, 23 ] }
the human homeobox gene hox7 maps to chromosome 4p16.1 and may be implicated in wolf-hirschhorn syndrome .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1417387", "name": "hox7", "pos": [ 24, 28 ] }
in humans , two mdr genes , mdr1 and mdr3 , with approximately 80 % nucleotide homology , have been identified .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 3, 9 ] }
{ "id": "C0376623", "name": "mdr genes", "pos": [ 16, 25 ] }
in humans , two mdr genes , mdr1 and mdr3 , with approximately 80 % nucleotide homology , have been identified .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 3, 9 ] }
{ "id": "C0376622", "name": "mdr1", "pos": [ 28, 32 ] }
in humans , two mdr genes , mdr1 and mdr3 , with approximately 80 % nucleotide homology , have been identified .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 3, 9 ] }
{ "id": "C1412071", "name": "mdr3", "pos": [ 37, 41 ] }
in 19 human meningiomas ( 14 primary and four recurrent tumors and one tumor transplanted into athymic nude mice ) , oncogene expression , amplification , and rearrangement , and loss of heterozygosity on chromosome 22 were examined .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 6, 11 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 117, 125 ] }
gs alpha was identified by comparing the adp-ribosylation patterns of myocardial membranes , membranes prepared from human leukemia ( hl 60 ) and s 49 mouse lymphoma wild type cells ( 45 kda-band present ) with membranes of the gs alpha-deficient s 49 variant cyc- ( 45 kda-band missing ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 117, 122 ] }
{ "id": "C1426584", "name": "cyc", "pos": [ 260, 263 ] }
as a model system , the thermal stabilities of heteroduplexes formed between a human alpha-globin cdna and four alpha-like globin genes isolated from chimpanzee are qualitatively compared .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 79, 84 ] }
{ "id": "C3825351", "name": "globin genes", "pos": [ 123, 135 ] }
in these chimeric abelson murine leukemia viruses , the tpk and carboxy-terminal regions of v-abl were replaced with the corresponding regions of d. melanogaster abl .
organism_has_gene
{ "id": "C0000742", "name": "abelson murine leukemia viruses", "pos": [ 18, 49 ] }
{ "id": "C0080279", "name": "v-abl", "pos": [ 92, 97 ] }
we report here the identification of multiple 344-bp segments of amoeba dna similar to the human multidrug resistance ( mdr ) gene using primers to conserved regions of the p-glycoprotein and the polymerase chain reaction ( pcr ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 91, 96 ] }
{ "id": "C0376623", "name": "multidrug resistance", "pos": [ 97, 117 ] }
one of these fragments yielded amino acid sequence information spanning fifteen residues , which was identified as probably belonging to human methyltransferase by virtue of both its significant sequence homology to three procaryote forms of o6-mt encoded by the ada , ogt ( both from e. coli ) and dat ( b. subtilis ) genes , and sequence position of the radiolabelled methyl group which matched the position of the conserved procaryote methyl acceptor site cysteine residue .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 137, 142 ] }
{ "id": "C3813713", "name": "dat", "pos": [ 299, 302 ] }
antibody-like molecules consisting of the human cd 4 extracellular domain fused to human igg1 heavy chain constant regions were genetically constructed and expressed in a bhk cell stable transfectant .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 42, 47 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 94, 105 ] }
permanent conversion of nih3t3 cells transformed by activated c-ha-ras , c-ki-ras , n-ras , or c-raf , and of human pancreatic adenocarcinoma containing activated c-ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 110, 115 ] }
{ "id": "C1537502", "name": "ki-ras", "pos": [ 165, 171 ] }
spontaneously immortalized human skin keratinocytes ( hacat ) were transfected with the c-ha-ras ( ej ) oncogene via a plasmid construct which also contained the selectable neomycin gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 27, 32 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 93, 96 ] }
spontaneously immortalized human skin keratinocytes ( hacat ) were transfected with the c-ha-ras ( ej ) oncogene via a plasmid construct which also contained the selectable neomycin gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 27, 32 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 104, 112 ] }
two human il-1 genes , alpha and beta , have been isolated , which encode polypeptides with only 20-30 % amino acid sequence homology .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1708431", "name": "il-1", "pos": [ 10, 14 ] }
we propose that immunoprecipitation of p53 by pab240 is diagnostic of mutation in both murine and human systems and suggest that the different point mutations which convert p53 from a recessive to a dominant oncogene exert a common conformational effect on the protein .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 98, 103 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 208, 216 ] }
the human progesterone receptor ( hpr ) cdna , synthesized from t47d breast cancer cells , and the hpr gene 5'-flanking region were cloned and sequenced .
organism_has_gene
{ "id": "C0086418", "name": "hpr", "pos": [ 34, 37 ] }
{ "id": "C1366500", "name": "hpr gene", "pos": [ 99, 107 ] }
we have determined the sequence of the 5'-flanking region and first three exons of the human na , k-atpase alpha 1 gene , atp1a1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 87, 92 ] }
{ "id": "C1412628", "name": "atp1a1", "pos": [ 122, 128 ] }
human cdna probes were used to examine the caprine central mhc and class i and ii genes by restriction fragment length polymorphism ( rflp ) and by pulsed field gel electrophoresis ( pfge ) in order to define the polymorphism and linkage of central mhc genes to class i and class ii genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0017349", "name": "class ii genes", "pos": [ 274, 288 ] }
these findings suggest that the responsiveness of some pituitary and adrenocortical hormones to specific stimuli is physiologically different in humans as a function of the clock timing , being higher in the evening than in the morning .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 145, 151 ] }
{ "id": "C1413503", "name": "clock", "pos": [ 173, 178 ] }
characterization of the clones revealed that the human il-7 gene contains six exons , distributed over more than 33-kbp .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1708437", "name": "il-7 gene", "pos": [ 55, 64 ] }
genes involved in ag presentation , hla-a , b , c in humans , are highly diverse whereas other class i genes are of much more limited diversity .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 53, 59 ] }
{ "id": "C0017355", "name": "class i genes", "pos": [ 95, 108 ] }
this work investigates the production of prostaglandin e2 ( pge2 ) , a well known modulator for the suppression of immune cells , by pre-implantation human conceptuses from the 4-cell stage to the hatched blastocyst and by cumulus oophorus cells , these being obtained from an ivf/et program .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 150, 155 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 277, 280 ] }
we have compared the affinities for t3 and the t3 analog binding characteristics of the in vitro translational products of seven c-erba cdnas ( chicken c-erba alpha ; human placental c-erba beta ; rat c-erba beta-1 ; rat c-erba alpha-1 ; rat c-erba alpha-2 ; human testis c-erba alpha-2 ; and human kidney c-erba alpha-2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 167, 172 ] }
{ "id": "C0242987", "name": "erba", "pos": [ 308, 312 ] }
four of these ( chicken c-erba alpha , human placental c-erba beta , rat c-erba beta-1 , rat c-erba alpha-1 ) bound t3 with high affinity as previously described .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C0242988", "name": "erba", "pos": [ 95, 99 ] }
when compared under identical conditions of synthesis and [ 125i ] t3 binding , there was no significant difference between the affinity of the chicken c-erb a alpha-1 and the human c-erba beta but in a more limited series the affinity of rat c-erba beta-1 for t3 was 4.6-fold higher than that of the rat c-erba alpha-1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 176, 181 ] }
{ "id": "C0242987", "name": "erba", "pos": [ 307, 311 ] }
in comparison with myoglobin and human and glycera dibranchiata hemoglobins , the heme distal side amino acid exchanges within the heme environment of elephant tetrameric hemoglobin ( hbe ) only slightly affect the electronic and esr spectra of hbe ( iii ) and hbe ( ii ) derivatives , several of which were prepared and characterized by optical and esr spectroscopy .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C1415484", "name": "hbe", "pos": [ 261, 264 ] }
molecular cloning of the human complement inhibitor sp-40,40 , has revealed strong homology to a major rat and ram sertoli cell product , sulfated glycoprotein-2 , known also as clusterin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C1413514", "name": "sp-40", "pos": [ 52, 57 ] }
long term effects of in vivo treatment with human ril-1 beta on diabetogenesis and thyroid disease were determined in the biobreeding rat .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 50, 53 ] }
thus , rhgm-csf augments accessory cell function by human monocytes , and this augmentation correlates with rhgm-csf-induced increases in transcription of the hla-dr and il-1 genes leading to increased expression of surface hla-dr and secretion of il-1 .
organism_has_gene
{ "id": "C0086418", "name": "rhgm-csf", "pos": [ 7, 15 ] }
{ "id": "C1708430", "name": "il-1 genes", "pos": [ 170, 180 ] }
activated human t lymphocytes express mhc class i heavy chains not associated with beta 2-microglobulin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 10, 15 ] }
{ "id": "C0017355", "name": "mhc class i", "pos": [ 38, 49 ] }
activated human t lymphocytes express mhc class i heavy chains not associated with beta 2-microglobulin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 10, 15 ] }
{ "id": "C1420192", "name": "heavy chains", "pos": [ 50, 62 ] }
administration to rats of 200 ng of human ril-1 by intracerebroventricular injection resulted in a more marked induction of circulating il-6 than the same dose of il-1 administered systemically ( intravenously or intraperitoneally ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 42, 45 ] }
since the initial human in vitro fertilization ( ivf-et ) procedure in 1978 , the laparoscope was the primary method for oocyte collection .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 18, 23 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 49, 52 ] }
studies on the loss of heterozygosity ( loh ) in human malignancies have shown that a number of different chromosomal regions associated with putative tumor suppressor genes may be involved in any one given tumor .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0079427", "name": "tumor", "pos": [ 207, 212 ] }
we examined the effects of transforming growth factor beta 1 ( tgf-beta 1 ) on various aspects of the cell biology of human endometrial carcinoma ( hec ) cell lines in vitro , as well as the expression of tgf-beta 1 mrna by these cell lines .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 118, 123 ] }
{ "id": "C1366557", "name": "tgf-beta 1", "pos": [ 205, 215 ] }
these results suggest that the sensitivity of human hec cell lines to tgf-beta 1 is variable and that this sensitivity is inversely correlated with the level of expression of tgf-beta 1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 46, 51 ] }
{ "id": "C1366557", "name": "tgf-beta 1", "pos": [ 175, 185 ] }
linkage analysis using 28 other markers on human chromosome 1 precisely locates the antiporter gene ( locus apnh ) on the genetic map of 1 p .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 43, 48 ] }
{ "id": "C1420232", "name": "apnh", "pos": [ 108, 112 ] }
sequences highly homologous to the three mt-sequences were also found in the 5'-flanking regions of the genes for the beta subunit of human f0f1-atpase and rat somatic cytochrome c .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 134, 139 ] }
{ "id": "C1426584", "name": "somatic cytochrome c", "pos": [ 160, 180 ] }
in this paper , i show that infection of primary human b cells with ebv increased the transcript level of the proto-oncogene , c-fgr , 10-fold .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0919478", "name": "c-fgr", "pos": [ 127, 132 ] }
its sequence translates into two overlapping open reading frames , tya3-1 and tyb3-1 , which encode proteins with homology to the proteins specified by the retroviral gag and pol genes , respectively .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 156, 166 ] }
{ "id": "C0017360", "name": "pol genes", "pos": [ 175, 184 ] }
a quantitative bioassay for human immunodeficiency viruses has been developed on the basis of the ability of the tat gene to transactivate the expression of an integrated beta-galactosidase gene in a hela-cd4+ cell line .
organism_has_gene
{ "id": "C0019682", "name": "human immunodeficiency viruses", "pos": [ 28, 58 ] }
{ "id": "C0017375", "name": "tat gene", "pos": [ 113, 121 ] }