text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in 7 families with primarily premenopausal breast cancer and ( in 5 families ) ovarian cancer , a dominant susceptibility allele may be linked to the genetic marker glutamicpyruvic transaminase or alanine aminotransferase ( gpt ; lod score 1.95 at zero recombination ) . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
181,
193
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
197,
221
]
} |
in 30 hp and in 34 np , the cardiac output and plasma concentrations of noradrenaline , adrenaline , and dopamine were also measured in the supine position and after 10 min of standing . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} |
from clinical observations and pharmacokinetic studies it is obvious that even short-term treatment with therapeutic doses of cimetidine inhibits the hepatic elimination of antipyrine , warfarin , diazepam , desmethyldiazepam , chlordiazepoxide , propranolol , labetalol , metoprolol , phenytoin , carbamazepine , chlormethiazole , theophylline and caffeine . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
197,
205
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
208,
225
]
} |
hereditary angioneurotic edema ( hae ) is a complement-related clinical disorder with a deficiency of the c1 esterase inhibitor protein . | NA | {
"id": "C0019243",
"name": "hereditary angioneurotic edema",
"pos": [
0,
30
]
} | {
"id": "C2717905",
"name": "deficiency of",
"pos": [
88,
101
]
} |
s-100 protein was not identified within pure neuroblastic tumors ( neuroblastoma , neuroepithelioma ) but could be identified within rare cells of the ganglioneuroblastoma and within the schwann cell component of ganglioneuroma . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
67,
80
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
151,
171
]
} |
moreover , vimentin was expressed together with cytokeratin in the carcinoma cells in 57 % of the keratin-positive samples as judged by double immunostaining , whereas the muscle type of intermediate filament protein , desmin , was not seen in the malignant cells . | NA | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
48,
59
]
} | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
187,
216
]
} |
glycoproteins synthesized and secreted into the growth medium were found to be only partially glycosylated and the extracellular limited proteolytic conversion of procollagen type i to collagen was impaired , with procollagen chains accumulating in the growth medium . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
166,
174
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
214,
225
]
} |
anionic and cationic contaminants are removed by ixc during purification of the samples , and further , the use of lipophilic ion exchangers allow the simultaneous reversed phase chromatographic elimination of neutral lipids . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
0,
7
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
203,
206
]
} |
anionic and cationic contaminants are removed by ixc during purification of the samples , and further , the use of lipophilic ion exchangers allow the simultaneous reversed phase chromatographic elimination of neutral lipids . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
12,
20
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
203,
206
]
} |
the carboxylic acid moieties of the steroid glucuronides were derivatised with diazomethane and the remaining functional groups in the steroids were thermally protected by methyloxime formation ( for carbonyls ) and trimethylsilylation ( for all steroidal and glucuronic acid hydroxyls ) . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
4,
19
]
} | {
"id": "C0020317",
"name": "acid hydroxyls",
"pos": [
271,
285
]
} |
the role of phosphoproteins and newly synthesized proteins in the hormonal regulation of steroidogenesis in leydig cells . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
12,
27
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
50,
58
]
} |
the results obtained both in experimental animals and in man by properly-timed administration of corticoids as well as personal observations in patients with addison 's disease given replacement therapy suggest that glucocorticoid action may not need continuous supply of hormone molecules to target cells but appropriate waves complying with the peripheral susceptibility . | NA | {
"id": "C0001617",
"name": "corticoids",
"pos": [
97,
107
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
272,
279
]
} |
in support of this concept it has been found that the concentrations of progesterone required to inhibit testosterone or dht binding to androgen receptors are lower in 5 alpha-reductase deficient fibroblasts than in control cells with high 5 alpha-reductase activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
196,
207
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
224,
229
]
} |
in addition the experiments performed on female and male rats to measure the effects of 2-ohe2 and 2-ohe1 on turnover rates of dopamine , norepinephrine and epinephrine in the anterior mediobasal hypothalamus and medial preoptic area show that the effects of catecholestrogens may partly be mediated by catecholamines . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
138,
152
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
157,
168
]
} |
the plasma value was below the detection limit for the assay ( approximately 15 pg/ml ) in men and non-pregnant women , but rose 20-200 pg/ml during pregnancy in 2-ohe1 and around 15 pg/ml in the 3rd trimester of pregnancy in 2-ohe2 . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
149,
158
]
} | {
"id": "C0032981",
"name": "3rd trimester",
"pos": [
196,
209
]
} |
simultaneous right and left adrenal and peripheral blood samples were collected for determination of cortisol ( f ) , progesterone ( p ) , 17-hydroxyprogesterone ( 17-ohp ) , aldosterone ( aldo ) , and deoxycorticosterone ( doc ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
118,
130
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
139,
161
]
} |
the effect is complex and depends on the concentration of sbp , albumin , and testosterone which in turn influences the distribution of testosterone between albumin and sbp . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
64,
71
]
} | {
"id": "C0033684",
"name": "sbp",
"pos": [
169,
172
]
} |
these data suggest a possible role of blph and bep in and/or other proopiocortin-related peptides in the development of adrenarche , while the lack of particular changes in these peptide levels during sexual maturation seems to exclude their role in gonadarche and pubertal development . | NA | {
"id": "C0023832",
"name": "blph",
"pos": [
38,
42
]
} | {
"id": "C0033195",
"name": "proopiocortin",
"pos": [
67,
80
]
} |
testosterone , progesterone , 17 alpha-hydroxyprogesterone and 20 alpha-dihydroprogesterone have been measured in the spermatic and peripheral venous blood of prepubertal boys undergoing surgery for undescended testis or inguinal hernia repair . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
15,
27
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
63,
91
]
} |
the metabolism of the biologically active d-norgestrel was more rapid than that of l-norgestrel which is biologically inactive . | NA | {
"id": "C0028368",
"name": "norgestrel",
"pos": [
44,
54
]
} | {
"id": "C0023566",
"name": "l-norgestrel",
"pos": [
83,
95
]
} |
however , there were differences between the isomers , d-norgestrel being converted mainly to the 16 beta-hydroxysteroid and l-norgestrel to the 16 alpha-hydroxysteroid . | NA | {
"id": "C0028368",
"name": "norgestrel",
"pos": [
57,
67
]
} | {
"id": "C0023566",
"name": "l-norgestrel",
"pos": [
125,
137
]
} |
disopyramide , 3 mg/kg , suppressed the arrhythmia in nine of 11 dogs at a minimum effective plasma concentration of 4.2 micrograms/ml , but produced ventricular fibrillation in the remaining two dogs . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
40,
50
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
150,
174
]
} |
both guanfacine and clonidine significantly inhibited urinary noradrenaline , dopamine , and cyclic nucleotide excretion , while urinary adrenaline levels were unaffected . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} |
the intramolecular conformational change which occurs in double-stranded ( dg-dc ) oligonucleotides and polynucleotides in high salt solutions is currently assumed to be a transition between the presently accepted structures for b-dna and z-dna . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
83,
99
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
104,
119
]
} |
in vitro myelopoiesis in a group of ten patients with acute leukemia ( 6 aml , 1 apml , 3 all ) in long-term remission has been studied . | NA | {
"id": "C0023467",
"name": "aml",
"pos": [
73,
76
]
} | {
"id": "C0023487",
"name": "apml",
"pos": [
81,
85
]
} |
pathophysiology , clinical manifestations and treatment of splenic disorders are viewed in terms of the broad spectrum of function ranging from asplenism through hypersplenism . | NA | {
"id": "C0037997",
"name": "splenic disorders",
"pos": [
59,
76
]
} | {
"id": "C0020532",
"name": "hypersplenism",
"pos": [
162,
175
]
} |
nuclei from confluent and mitotically arrested populations of human diploid fibroblast-like cells were subjected to digestion by micrococcal nuclease and deoxyribonuclease ( dnase i ) following the removal of various histone components by salt extraction . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
76,
86
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
the effect of plasma lipid reduction on the progression of femoral atherosclerosis was studied in hyperlipidaemic patients with stable intermittent claudication . | NA | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
67,
82
]
} | {
"id": "C0021775",
"name": "intermittent",
"pos": [
135,
147
]
} |
like the pyrazolopyridines , the enhancement of 3h-flunitrazepam binding by ly81067 is dependent on chloride or related anions and is reversed by picrotoxin , suggesting that ly81067 exerts its anticonvulsant effects by binding to or near picrotoxin binding sites . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
100,
108
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
120,
126
]
} |
if any endogenous cholesterol is available , smooth muscle cell cholesterol needs for proliferation can be supplied by ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
18,
29
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
119,
134
]
} |
in human plasma , catecholamines are conjugated almost entirely with sulfate while , in rat plasma , glucuronides are the main conjugates of epinephrine and dopamine but not norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
141,
152
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
174,
188
]
} |
addition of the non-hydrolyzable guanine nucleotide , guanylyl-imidodiphosphate simultaneously increases the rate of high affinity agonist binding and agonist promoted gdp release . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
33,
51
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
168,
171
]
} |
agonists displaced with an order of affinity clonidine greater than ( - ) adrenaline greater than ( - ) noradrenaline greater than dopamine greater than ( - ) isoprenaline but all displayed apparent hill coefficients less than unity indicating heterogeneity of binding . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
74,
84
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
104,
117
]
} |
the conversion of synthetic somatostatin-28 ( s-28 ) to somatostatin-14 ( s-14 , srif ) by subcellular fractions of rat hypothalamus has been investigated . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
28,
43
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
81,
85
]
} |
galactitol accumulation by glucose-6-phosphate deficient fibroblasts : a cellular model for resistance to the complications of diabetes mellitus . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
73,
81
]
} |
since aldose reductase and sorbitol dehydrogenase activities in experimental and control fibroblasts are identical , the effect is most likely due to the substantial reduction in nadph levels in severely g6pd-deficient cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
219,
224
]
} |
sorbitol does not accumulate either in control or in g6pd deficient fibroblasts incubated in high glucose medium , most likely because of the action of sorbitol dehydrogenase , and the presence of a carrier-mediated glucose transport system in the cell membrane which limits the concentration of glucose that can accumulate in these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
333,
338
]
} |
in contrast , quisqualic acid , ibotenic acid , glutamatic acid , homocysteic acid and 2-amino-4-phosphono butyric acid were moderately potent displacers . | NA | {
"id": "C0080074",
"name": "quisqualic acid",
"pos": [
14,
29
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
89,
94
]
} |
the effects of cholecystokinin-octapeptide ( cck8 ) , the biologically active c-terminal moiety of cholecystokinin ( cck ) , on the binding of epidermal growth factor ( egf ) were studied in isolated rat pancreatic acini . | NA | {
"id": "C0037167",
"name": "cholecystokinin-octapeptide",
"pos": [
15,
42
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
99,
114
]
} |
in contrast to cck8 , the gastrointestinal hormone vasoactive intestinal polypeptide ( vip ) did not significantly alter egf binding . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormone",
"pos": [
26,
50
]
} | {
"id": "C0042395",
"name": "vasoactive intestinal polypeptide",
"pos": [
51,
84
]
} |
levels of coa , acetyl coa , carnitine and acetyl carnitine decreased while those of long chain acyl coa and long chain acyl carnitine enhanced . | NA | {
"id": "C0001026",
"name": "acetyl coa",
"pos": [
16,
26
]
} | {
"id": "C0001374",
"name": "long chain acyl coa",
"pos": [
85,
104
]
} |
the proportion of ne and epi ranged between 60-80 % and 20-40 % respectively , of total tumor ca . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
18,
20
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
25,
28
]
} |
an humoral syndrome leading to a presomptive diagnosis consists of hypoglycemia , hypercholesterolemia , hyperlipemia , and high blood level of alcaline phosphatases . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
82,
102
]
} | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
105,
117
]
} |
in developing countries , efforts must be directed towards three goals : -- epidemiology : detection of the predisposing factors such as traumatisms , the use of bethel , kath , tobacco , and , above all , alcohol ( beer consumption is steadily increasing in african countries ) . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
206,
213
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
216,
220
]
} |
we examined the response of plasma glucose concentration and glucose counterregulatory factors ( eg , glucagon , epinephrine , growth hormone , cortisol , and norepinephrine ) to insulin-induced hypoglycemia in four patients with shy-drager syndrome and in five control subjects to determine if glucose counterregulation occurred in the patients with sympathetic and parasympathetic nervous system defects . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
113,
124
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
159,
173
]
} |
soft tissue injury to one hindlimb produced trauma in rats without affecting their food intake or weight gain . | NA | {
"id": "C0037578",
"name": "soft tissue injury",
"pos": [
0,
18
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
44,
50
]
} |
to study this , the activities of hepatic lipase and lipoprotein lipase were determined in control subjects , in two patients with heterozygous hypobetalipoproteinemia , and in three patients with phenotypic abetalipoproteinemia after administration of heparin . | NA | {
"id": "C0020597",
"name": "hypobetalipoproteinemia",
"pos": [
144,
167
]
} | {
"id": "C0000744",
"name": "abetalipoproteinemia",
"pos": [
208,
228
]
} |
both enzymes showed normal activity in the patients with hypobetalipoproteinemia , but showed consistently reduced activity in the patients with abetalipoproteinemia . | NA | {
"id": "C0020597",
"name": "hypobetalipoproteinemia",
"pos": [
57,
80
]
} | {
"id": "C0000744",
"name": "abetalipoproteinemia",
"pos": [
145,
165
]
} |
the appearance of the discrete restriction fragments from the pathogenic t. pallidum dna does not represent a contamination of satellite dna from rabbit , the host in which the organism was propagated , but rather represents the presence of redundant dna or dna of less complexity in the pathogenic t. pallidum dna preparation . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
311,
314
]
} |
spontaneous tandem genetic duplications of portions of bacterial chromosomes can be trapped by transducing a selectable marker from a donor to a recipient that has a different selectable marker at the same genetic location and selecting transductants with both markers . | NA | {
"id": "C0017393",
"name": "marker",
"pos": [
120,
126
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
261,
268
]
} |
we tested the effect of edta or asc on contractile responses of hamster cremaster arterioles and rat aortic strips to epinephrine ( epi ) or norepinephrine ( nor ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
118,
129
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
141,
155
]
} |
comparable contractile responses were elicited by lower epi or nor concentrations in the presence than in the absence of edta or asc . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
56,
59
]
} | {
"id": "C0028351",
"name": "nor",
"pos": [
63,
66
]
} |
rapidly prepared and administered solutions of epi or nor elicited similar initial responses in the presence or absence of edta or asc . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
47,
50
]
} | {
"id": "C0028351",
"name": "nor",
"pos": [
54,
57
]
} |
we conclude that oxidation of epi and nor reduces apparent vascular reactivity and that edta or asc prevents or delays the reduction . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
30,
33
]
} | {
"id": "C0028351",
"name": "nor",
"pos": [
38,
41
]
} |
comparisons between the three series indicate a statistically significant ( p less than 0.05 ) increase in survival rates for children with leukemia and cancer of the central nervous system as well as a nonstatistically significant increase for children with lymphoma ( both hodgkin 's and non-hodgkin 's ) . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
259,
267
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
290,
304
]
} |
in terms of adenylate cyclase activation , three full agonists ( isoproterenol , epinephrine , and norepinephrine ) , four partial agonists ( procaterol , salbutamol , fenoterol , and zinterol ) , and four antagonists ( propranolol , metoprolol , atenolol , and practolol ) were tested . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
81,
92
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
99,
113
]
} |
by molecular sieving , two alkylated hemoglobins were separated : a hemoglobin fraction with an unchanged low tetramer dimer dissociation , normal electronic spectra , and normal digestibility by carboxypeptidase a ; | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
37,
48
]
} | {
"id": "C0019016",
"name": "a hemoglobin",
"pos": [
66,
78
]
} |
covalent drug binding , but not nitroreduction , was inhibited up to 80-85 % by 2 mm l-cysteine , n-acetyl-l-cysteine , or glutathione ; | NA | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
85,
95
]
} | {
"id": "C0001047",
"name": "n-acetyl-l-cysteine",
"pos": [
98,
117
]
} |
measurements of the incorporation of [ 3h ] c9ado into total cellular nucleic acids indicated that the labeling of rna was 40-80 % greater than that of dna . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
70,
83
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
152,
155
]
} |
these latter two strains were less sensitive , respectively , to e-5- ( 2-bromovinyl ) -2'-deoxyuridine ( brvdurd ) and to both brvdurd and 9- ( 2-hydroxyethoxymethyl ) guanine ( acyclovir ) . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
169,
176
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
179,
188
]
} |
the sequences of two of the most abundant scrnas from 20s rnp particles with chain lengths of 104 ( alpha 1-rna ) and 124 ( beta 1-rna ) nucleotides , respectively , are presented . alpha 1-rna shows a high sequence homology to the 3'-end of 18s rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
44,
47
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
246,
250
]
} |
hypermethylation was a reproducible phenomenon in hm , yielding tk- variants after selection with either bromodeoxyuridine or acycloguanosine [ acyclovir or 9- ( 2-hydroxyethy-oxymethyl ) guanine ] . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
144,
153
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
188,
195
]
} |
this antibody , which represents 25 % of the total antibody precipitated by the homologous antigen cross-reacts with the glycoprotein hemagglutinating lectins from sophora japonica ( sjl ) , w. floribunda ( wfa ) and the glycoprotein bromelain , but not the protein lectin from maclura pomifera seeds . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
151,
158
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
258,
265
]
} |
odc activity decreased by more than 99 % after 12 h treatment and putrescine and spermidine levels also decreased dramatically . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
66,
76
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
92,
98
]
} |
spermine , not normally present in control cells , increased to detectable , low levels ( less than 1 nmol mg-1 protein ) after 36 h treatment . alpha-dl-difluoromethylornithine-treated cells were unable to synthesize putrescine from [ 3h ] ornithine but were able to convert [ 3h ] putrescine + methionine to spermidine . | NA | {
"id": "C0002260",
"name": "alpha",
"pos": [
145,
150
]
} | {
"id": "C0029277",
"name": "ornithine",
"pos": [
241,
250
]
} |
milrinone , a derivative of amrinone , has nearly 20 times the inotropic potency of the parent compound and does not cause fever or thrombocytopenia in normal volunteers or in animals sensitive to amrinone . | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
0,
9
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
197,
205
]
} |
development of the mycelial form was observed with all of the carbon sources tested ( glucose , fructose , mannose , arabinose , maltose , sucrose and starch ) while the yeast form developed only when glucose or another hexose was added to the medium . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
96,
104
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
220,
226
]
} |
development of the mycelial form was observed with all of the carbon sources tested ( glucose , fructose , mannose , arabinose , maltose , sucrose and starch ) while the yeast form developed only when glucose or another hexose was added to the medium . | NA | {
"id": "C0024742",
"name": "mannose",
"pos": [
107,
114
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
220,
226
]
} |
development of the mycelial form was observed with all of the carbon sources tested ( glucose , fructose , mannose , arabinose , maltose , sucrose and starch ) while the yeast form developed only when glucose or another hexose was added to the medium . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
86,
93
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
220,
226
]
} |
during the degradation of thioglucosides in defatted rape seed meal ( res ) microorganisms were found , whose ability to degrade glucosinolates ( gsl ) and vinyl thio-oxazolidone ( vto ) was not known so far . | NA | {
"id": "C0039898",
"name": "thioglucosides",
"pos": [
26,
40
]
} | {
"id": "C0017767",
"name": "glucosinolates",
"pos": [
129,
143
]
} |
here we extend our observations on the mg2+-atpase and demonstrate that flash illumination following the dark atpase process stimulated atpase activity at a rate considerably faster than the dark process . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
39,
42
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
136,
142
]
} |
by analogy with the 5s rna system , where a transcription factor required for 5s dna expression was shown to interact both with 5s rna and with the noncoding strand of the 5s gene , we explored the possibility that a protein which normally binds to trna could also interact with the trna gene and regulate its transcription . | NA | {
"id": "C0040648",
"name": "transcription factor",
"pos": [
44,
64
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
217,
224
]
} |
here , using molecular clones of htlv and human major histocompatibility antigen dna , we have shown homology between the envelope gene region of htlv and the region of an hla-b locus gene which codes for the extracellular portion of a class i histocompatibility antigen . | NA | {
"id": "C0019628",
"name": "histocompatibility antigen",
"pos": [
54,
80
]
} | {
"id": "C0019629",
"name": "class i",
"pos": [
236,
243
]
} |
this gene was cloned from a recombinant library of burkitt 's lymphoma dna and identified as a human homologue of chicken blym-1 , the transforming gene detected by transfection of chicken b-cell lymphoma dna . | NA | {
"id": "C0012931",
"name": "recombinant",
"pos": [
28,
39
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
we have previously suggested that two lymphokine activities-macrophage activating factor ( maf ) and gamma interferon ( ifn-gamma ) -are mediated by the same molecule . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
38,
48
]
} | {
"id": "C0079786",
"name": "macrophage",
"pos": [
60,
70
]
} |
time-dependent augmentation of the contractile responses to adrenaline and noradrenaline of the guinea-pig esophageal muscularis mucosae in vitro . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
60,
70
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
some of the extraneuronal accumulation of 3h- ( - ) noradrenaline in the rabbit aorta was resistant to uptake2 inhibitors ( corticosterone , normetanephrine , phenoxybenzamine ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
141,
156
]
} |
the 4s nuclear rna , as well as high molecular rna are apt to induce antibody synthesis . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
7,
18
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
47,
50
]
} |
the concentrations of alanine , glutamate , and gamma-amino-butyric acid decreased , and the concentration of aspartate increased , in the brains of the hypoglycemic rats . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
22,
29
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
54,
59
]
} |
analysis of free amino acids in the cerebral cortex , midbrain , and cerebellum showed increases in gaba and glycine levels in all three regions , a significant increase in taurine in midbrain , and an increase in lysine in cerebral cortex and cerebellum . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
17,
28
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
109,
116
]
} |
studies with cell-specific antisera revealed the presence of neurons , glial cells , oligodendrocytes and fibroblast-like cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
13,
17
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
106,
116
]
} |
pentobarbital , an anesthetic barbiturate , had no effect on basal or k+-stimulated release of [ 3h ] -d-aspartate or [ 14c ] -gaba but potentiated the enhancement of [ 3h ] -d-aspartate release by muscimol . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
0,
13
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
30,
41
]
} |
phenobarbital , an anticonvulsant barbiturate , enhanced release of [ 3h ] -d-aspartate and [ 14c ] -gaba in the absence of muscimol . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
0,
13
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
34,
45
]
} |
we conclude that myositis of chronic gvhd can present as a severe myopathy that responds to steroids and differs from cd . | NA | {
"id": "C0027121",
"name": "myositis",
"pos": [
17,
25
]
} | {
"id": "C0026848",
"name": "myopathy",
"pos": [
66,
74
]
} |
seizures were recorded with depth electrodes as part of the evaluation for possible surgery for epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
0,
8
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
96,
104
]
} |
these uncoupling actions of bcc were similar to those of amphetamine ( 20 microm ) or dopamine ( 10-20 microm ) and were abolished by the presence of a dopaminergic blocker , haloperidol ( 20-40 microm ) . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
86,
94
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
152,
164
]
} |
when the cells were corrected for the lacking enzyme by adding conditioned medium from control fibroblasts , the chemotactic migration increased except for mps type ii cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
95,
106
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
168,
173
]
} |
atomic absorption spectrometric analysis of the circulated blood provided confirmatory evidence of spallation , and concentrations of polydimethylsiloxane ( silicone ) rose in parallel with the duration of use . | NA | {
"id": "C0012436",
"name": "polydimethylsiloxane",
"pos": [
134,
154
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
157,
165
]
} |
a case of a peripheral lung tumour histologically categorized as a sclerosing hemangioma of the lung is presented . | NA | {
"id": "C0024121",
"name": "of",
"pos": [
7,
9
]
} | {
"id": "C1334455",
"name": "sclerosing",
"pos": [
67,
77
]
} |
to determine the etiology of apparent meningococcemia , all cases of sepsis with coagulopathy , purpura , and/or adrenal hemorrhage ( waterhouse-friderichsen syndrome ) with and without shock occurring over a 12-year period were reviewed . | NA | {
"id": "C0005779",
"name": "coagulopathy",
"pos": [
81,
93
]
} | {
"id": "C0034150",
"name": "purpura",
"pos": [
96,
103
]
} |
children with clinical signs of sepsis and with purpura , petechiae , or coagulopathy may have n meningitidis or h influenzae as etiologic agents . | NA | {
"id": "C0034150",
"name": "purpura",
"pos": [
48,
55
]
} | {
"id": "C0005779",
"name": "coagulopathy",
"pos": [
73,
85
]
} |
an f element did insert into a ribosomal insertion-like sequence , followed by the introduction of a g sequence into f . | NA | {
"id": "C0016330",
"name": "f element",
"pos": [
3,
12
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
117,
118
]
} |
a long target dna is progressively shortened from one end , by digestion with bal31 nuclease or exonuclease iii and nuclease s1 , followed by cleaving off the shortened vector dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
176,
179
]
} |
overall , the main leghemoglobin locus is similar in structure to the mammalian globin gene loci . | NA | {
"id": "C0023235",
"name": "leghemoglobin",
"pos": [
19,
32
]
} | {
"id": "C0017645",
"name": "globin",
"pos": [
80,
86
]
} |
the effect of this methylation on the 5.8s rna structure and 5.8-28s rrna junction was investigated using both chemical and physical approaches . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
43,
46
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
69,
73
]
} |
modification-exclusion studies indicated that the first 29 nucleotides at the 5 ' end and residues 140 through 158 at the 3 ' end affect the 5.8s-28s rrna interaction , supporting previous suggestions that the 5.8s rna interacts with its cognate high molecular weight component through its termini . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
150,
154
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
215,
218
]
} |
[ retinol carrier protein , prealbumin and transferrin . influence of age and sex on the serum concentration of proteins with a short half-life ] . | NA | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
10,
25
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} |
treatment of hyperoxaluria is both medicinal and dietetic : control of oxalic acid-rich food intake and reduction of the intestinal absorption of oxalate caused by calcium-deprived diets . | NA | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
71,
82
]
} | {
"id": "C0029988",
"name": "oxalate",
"pos": [
146,
153
]
} |
these results suggest that the isolated protein-lipid complex may be a component of the opiate receptor and , specifically , the mu receptor or binding site . | NA | {
"id": "C0034801",
"name": "opiate receptor",
"pos": [
88,
103
]
} | {
"id": "C0066908",
"name": "mu receptor",
"pos": [
129,
140
]
} |
both of the adult alpha-globin genes were more actively expressed than the embryonic zeta-globin genes in these transformed cell lines . | NA | {
"id": "C0002270",
"name": "alpha-globin",
"pos": [
18,
30
]
} | {
"id": "C0043472",
"name": "zeta-globin",
"pos": [
85,
96
]
} |
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