text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the antimicrobial combinations used were penicillin plus clavulanic acid and metronidazole plus penicillin , oxacillin , or gentamicin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
41,
51
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
109,
118
]
} |
during a one-year survey of a children 's residence housing 20 young children and employing 29 adults , a confirmed outbreak of type c influenza unassociated with other known respiratory infections was studied . | NA | {
"id": "C0008059",
"name": "children 's",
"pos": [
30,
41
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
63,
77
]
} |
failure to cure the infection occurred significantly more frequently among patients treated with cefoperazone or cefamandole than among those treated with clindamycin and gentamicin in combination . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
97,
109
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
113,
124
]
} |
[ congestive cardiomyopathy , peripheral neuropathy , abnormal ct findings , neurosensory deafness , cerebellar ataxia and ophthalmoplegia in oculocraniosomatic neuromuscular disease with ragged red fibers ] . | NA | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
30,
51
]
} | {
"id": "C0027868",
"name": "neuromuscular disease",
"pos": [
161,
182
]
} |
consistent with this are the findings by borello and gorlin ( 1966 ) of high urinary vanillylmandelic acid excretion in one case and the correlation of tumour enzyme patterns with those of paragangliomas , neuroblastomas and phaeochromocytomas . | NA | {
"id": "C0030421",
"name": "paragangliomas",
"pos": [
189,
203
]
} | {
"id": "C0031511",
"name": "phaeochromocytomas",
"pos": [
225,
243
]
} |
the effect of fat feeding ( 100 g of cream ) on the apoa-i isoproteins distribution has been analyzed by two-dimensional gel electrophoresis in the chylomicrons , vldl , ldl , and hdl isolated from the thoracic duct lymph of patients undergoing lymph drainage for immunosuppression , isoforms apoa-i3 and apoa-i4 are the most abundant apoa-i isoproteins in plasma lipoproteins as well as in lymph lipoproteins collected in the fasting state . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
148,
160
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
397,
409
]
} |
fat feeding , on the other hand , results in a marked change in the apoa-i isoform pattern in lymph chylomicrons and vldl , with a significant increase in the relative concentration of the apoa-i1 isoform . | NA | {
"id": "C0085201",
"name": "apoa-i",
"pos": [
68,
74
]
} | {
"id": "C0003592",
"name": "apoa",
"pos": [
189,
193
]
} |
adenosine and alpha ( 2 ) -adrenergic antilipolytic effects were estimated through the inhibition of theophylline-induced lipolysis by phenylisopropyladenosine and clonidine , respectively . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
135,
159
]
} |
twenty-four hours after resection of intraperitoneal adhesions she had granulocytopenia and leukopenia with a marked `` '' left shift '' '' ; | NA | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
71,
87
]
} | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
92,
102
]
} |
loss of 12-hete synthesis ( 16-fold reduction relative to 5-hete ) in a23187-stimulated cultures provided a convenient measure of platelet depletion . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
8,
15
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
60,
64
]
} |
tumor antibody uptakes ( as compared with the whole mouse ) , ranging between 7 and 15 , and specificity indices ranging between 3.4 and 6.8 , were obtained with the four intact mab at day 4-5 after injection . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
6,
14
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
178,
181
]
} |
with f ( ab ' ) 2 fragments of the four mab , at day 3 , the tumor antibody uptakes ranged between 12 and 24 and the specificity indices between 5.3 and 8.2 . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
40,
43
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} |
with the fab fragments prepared from the two most promising mab , the antibody uptakes reached values of 34 and 82 at day 2-3 and the specificity indices were as high as 12 and 19 . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
60,
63
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
70,
78
]
} |
studies with free natural and synthetic oligosaccharides identified the disaccharide glcnac beta 1 leads to 3gal beta as one critical binding site . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
40,
56
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
72,
84
]
} |
mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions , lfa-1 and mac-1 . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
11,
20
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
36,
44
]
} |
mouse mac-1 , a complement receptor-associated surface structure on macrophages , and lfa-1 , a function-associated structure on lymphocytes , comprise a novel family of leukocyte differentiation antigens participating in adhesive cell interactions . | NA | {
"id": "C0079785",
"name": "mac-1",
"pos": [
6,
11
]
} | {
"id": "C0034793",
"name": "complement receptor",
"pos": [
16,
35
]
} |
two mab to mac-1 alpha-subunit epitopes but not a third mab to a spatially distinct alpha-epitope inhibited complement receptor function . | NA | {
"id": "C0079785",
"name": "mac-1",
"pos": [
11,
16
]
} | {
"id": "C0034793",
"name": "complement",
"pos": [
108,
118
]
} |
nonmalignant cells examined included st0 , 3t3/balb , and 3t3/l1 fibroblasts and unstimulated , as well as mitogen-stimulated murine splenocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} |
based on the absence of cross-reactions by igg2a-specific monoclonal autoantibodies , certain peptides of the igg ch2 and ch3 domains appear to generate the antigenic determinants of the anti-igg2a rf in mrl/l mice . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
69,
83
]
} | {
"id": "C0035448",
"name": "rf",
"pos": [
198,
200
]
} |
anticlonotypic monoclonal antibodies to the 49/43-kdalton heterodimer of a given clone or antibodies to the 20/25-kdalton membrane associated monomorphic t3 molecule selectively induce proliferation and il-2 secretion when linked to a solid support . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
15,
36
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
90,
100
]
} |
the results demonstrate that the diagnostic terms hysteria and hypochondriasis ( now included under somatoform disorders ) are infrequently recorded and poorly distinguished from depression and anxiety . | NA | {
"id": "C0020604",
"name": "hypochondriasis",
"pos": [
63,
78
]
} | {
"id": "C0037650",
"name": "somatoform disorders",
"pos": [
100,
120
]
} |
a succinate dehydrogenase-negative mutant of bacillus subtilis is described which lacks all three subunits of the membrane-bound succinate dehydrogenase complex : flavoprotein , iron protein , and cytochrome b558 . | NA | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
163,
175
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
183,
190
]
} |
furthermore , ovine cells were more sensitive ( p less than 0.01 ) to human inf-alphas than human fibroblasts ( trisomic or disomic for chromosome 21 ) or bovine cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
162,
167
]
} |
both of these syndromes present serious treatment challenges to clinicians and in an effort to deal more effectively with these disorders several pharmacological interventions have been attempted . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
14,
23
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
128,
137
]
} |
radioenzymatic assays showed that high levels of dopamine were present but only small amounts of the catecholamines norepinephrine and epinephrine were identified . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
116,
130
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
135,
146
]
} |
the antiserum formed could be demonstrated by means of crossed immunoelectrophoresis to contain antibodies to one to three ms antigens . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
4,
13
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
96,
106
]
} |
regulation of cellular content of the endogenous opioid peptides met5-enkephalin and leu5-enkephalin was investigated in neuroblastoma x glioma hybrid cells ng108-15 grown in both serum-supplemented and serum-free defined media . | NA | {
"id": "C0205753",
"name": "endogenous opioid peptides",
"pos": [
38,
64
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
90,
100
]
} |
cardiac output , pulmonary capillary wedge pressure , arterial blood pressure , arterial and mixed venous blood gases , and arterial and mixed venous epinephrine ( e ) and norepinephrine ( ne ) levels were measured serially in 15 patients during the first 3 days after injury . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
150,
161
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
172,
186
]
} |
elevated mbp levels were found in 44 % of patients with congenital hydrocephalus , 75 % of patients with posttraumatic hydrocephalus , 80 % of patients with normal-pressure hydrocephalus , and 83 % of patients with porencephaly . | NA | {
"id": "C0020255",
"name": "hydrocephalus",
"pos": [
67,
80
]
} | {
"id": "C0020258",
"name": "normal-pressure hydrocephalus",
"pos": [
157,
186
]
} |
following intravenous injection of labeled choline or phosphorylcholine in rats and mice , the brain uptake as percent injected dose was less than 0.2 % with 6-12 % going to kidney and 3-6 % to liver . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
43,
50
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
54,
71
]
} |
at 1 hour , the carbohydrate-sensitive men given sucrose had significantly higher insulin levels than carbohydrate-sensitive men given invert sugar ( disaccharide effect ) . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
49,
56
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
150,
162
]
} |
experiments were conducted to determine whether lysine-induced hyperlipidemia is secondary to the antagonistic effect of lysine on arginine or to the anorexia which accompanies lysine feeding , and in addition , whether the lysine-induced hypercholesterolemia is affected by chick age . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
63,
77
]
} | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
239,
259
]
} |
among all the phosphoglycerides , the fatty acid composition of the phosphatidylcholine exhibited the largest alterations as a result of coconut oil feeding . | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
14,
31
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
68,
87
]
} |
this study was conducted to investigate whether a moderate running exercise would enhance or prevent the lipid peroxidation in animal body and also stimulate or depress the degradation-excretion of lipid peroxides ( lipox , thiobarbituric acid reactive substances determined as malon dialdehyde ) in young female rats . | NA | {
"id": "C0162781",
"name": "thiobarbituric acid reactive substances",
"pos": [
224,
263
]
} | {
"id": "C0024643",
"name": "malon dialdehyde",
"pos": [
278,
294
]
} |
twenty-one male university students were given spi ( supro 620 , ralston purina co. , st. louis , mo. , u.s.a. ) , fish protein ( cod fish ) or a 50:50 mixture of the two proteins as the sole source of protein . | NA | {
"id": "C0598294",
"name": "fish protein",
"pos": [
115,
127
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
202,
209
]
} |
the nitrogen requirement for maintenance of nitrogen equilibrium determined from the regression equation was 118.1 +/- 15.4 mg n/kg/day for spi , 87.1 +/- 17.2 mg n/kg/day for fish protein and 90.5 +/- 17.1 mg n/kg/day for mixed protein . | NA | {
"id": "C0598294",
"name": "fish protein",
"pos": [
176,
188
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
229,
236
]
} |
the npus calculated at the respective maintenance nitrogen intakes were 38.9 , 52.8 and 50.8 for spi , fish protein and mixed protein , respectively . | NA | {
"id": "C0598294",
"name": "fish",
"pos": [
103,
107
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
126,
133
]
} |
there was no significant difference between the nutritive values of mixed protein and fish protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
74,
81
]
} | {
"id": "C0598294",
"name": "fish protein",
"pos": [
86,
98
]
} |
the prevalence of low serum ferritin levels was about 8 % in patients with rou , 15 % in bs and 9.5 % in patients with other ulcerative oral lesions , compared with less than 3 % in patients with non-ulcerative oral disorders and in controls . | NA | {
"id": "C0004943",
"name": "bs",
"pos": [
89,
91
]
} | {
"id": "C0026636",
"name": "oral disorders",
"pos": [
211,
225
]
} |
the long-term dimensional stability of three non-aqueous elastomeric impression materials , a silicone , a polyether and a polysiloxane , were investigated . | NA | {
"id": "C0037114",
"name": "silicone",
"pos": [
94,
102
]
} | {
"id": "C0037121",
"name": "polysiloxane",
"pos": [
123,
135
]
} |
after 4 weeks the polysiloxane maintained the best surface detail , the polyether was adequate but the silicone lost much of its detail in as little as 24 h . | NA | {
"id": "C0037121",
"name": "polysiloxane",
"pos": [
18,
30
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
103,
111
]
} |
zinc as znso4 and copper as cucl2 were then added to individual infants ' formulations , with intakes ranging from 91 to 824 micrograms/kg/day ( zinc ) and 8 to 92 micrograms/kg/day ( copper ) . | NA | {
"id": "C0056593",
"name": "cucl2",
"pos": [
28,
33
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
184,
190
]
} |
studies were designed to assess factors other than pathologic status of the cell donor which affect the blastogenic responsiveness in vitro of peripheral blood mononuclear cells ( pbms ) from normal donors and patients with periodontitis . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
76,
80
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
143,
159
]
} |
when the supporting drug treatment consisted of pyridostigmine pretreatment and therapy with atropine and diazepam ( this treatment itself gave considerable protection against organophosphate poisoning ) both the non-oxime and oxime derivatives increased the protection against all four agents although obidoxime and tmb-4 were not beneficial against soman poisoning . | NA | {
"id": "C0700359",
"name": "organophosphate poisoning",
"pos": [
176,
201
]
} | {
"id": "C0032343",
"name": "poisoning",
"pos": [
357,
366
]
} |
when the supporting drug treatment consisted of pyridostigmine pretreatment and therapy with atropine and diazepam ( this treatment itself gave considerable protection against organophosphate poisoning ) both the non-oxime and oxime derivatives increased the protection against all four agents although obidoxime and tmb-4 were not beneficial against soman poisoning . | NA | {
"id": "C0030020",
"name": "oxime",
"pos": [
217,
222
]
} | {
"id": "C0041028",
"name": "tmb-4",
"pos": [
317,
322
]
} |
concentration versus time profiles from the isolated lung experiments indicate rapid metabolism of isosorbide dinitrate and corresponding increases in the metabolites 5-isosorbide mononitrate , 2-isosorbide mononitrate , and isosorbide . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
99,
119
]
} | {
"id": "C0064079",
"name": "isosorbide mononitrate",
"pos": [
196,
218
]
} |
concentration versus time profiles from the isolated lung experiments indicate rapid metabolism of isosorbide dinitrate and corresponding increases in the metabolites 5-isosorbide mononitrate , 2-isosorbide mononitrate , and isosorbide . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
99,
119
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
225,
235
]
} |
concentration versus time profiles from the isolated lung experiments indicate rapid metabolism of isosorbide dinitrate and corresponding increases in the metabolites 5-isosorbide mononitrate , 2-isosorbide mononitrate , and isosorbide . | NA | {
"id": "C0064079",
"name": "isosorbide mononitrate",
"pos": [
169,
191
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
225,
235
]
} |
the metabolism of isosorbide dinitrate in lung homogenate 9000 x g supernatant exhibited a metabolic scheme kinetically different from the intact lung studies , as isosorbide was formed slowly from a mononitrate intermediate and not by a near-simultaneous cleavage of both nitrate ester groups . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
18,
38
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
164,
174
]
} |
the effects of the organic calcium antagonists verapamil and methoxyverapamil ( d-600 ) on vasopressin-stimulated water flow in response to an osmotic gradient were investigated . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
47,
56
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
61,
77
]
} |
three other gaba transaminase inhibitors , gamma-vinyl gaba ( 450 and 900 mg/kg i.p . ) , gamma-acetylenic gaba ( 50-150 mg/kg i.p . ) and ethanolamine-o-sulfate ( 250-750 mg/kg i.p . ) , were inactive against ethanol withdrawal audiogenic seizures and forelimb tremors . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
43,
59
]
} | {
"id": "C0016904",
"name": "gamma",
"pos": [
90,
95
]
} |
these changes were not related to changes in the precursor indoles tryptophan , 5-hydroxytryptophan and serotonin , which were unaltered by lithium treatment . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
67,
77
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
80,
99
]
} |
the rate of prostanoid release from the serosal surface of the mucosa only was increased after incubation th either bradykinin , lys-bradykinin , melittin or the calcium ionophore a 23187 , in a rapid and dose-dependent fashion . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
116,
126
]
} | {
"id": "C0022474",
"name": "lys-bradykinin",
"pos": [
129,
143
]
} |
the asymmetrical generalization with lorazepam and pentobarbital suggests a specificity of discriminative stimulus effects that heretofore have not been documented in drug discrimination experiments with benzodiazepines and barbiturates . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
51,
64
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
224,
236
]
} |
adriamycin , daunorubicin , desacetyladriamycin and aclacinomycin a all stimulated lipid peroxidation maximally when included at concentrations of 100 to 200 microm , whereas carminomycin and 4-demethoxydaunorubicin produced equivalent enhancement of peroxidation at lower concentrations of 30 to 50 microm . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
13,
25
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
175,
187
]
} |
adriamycin , daunorubicin , desacetyladriamycin and aclacinomycin a all stimulated lipid peroxidation maximally when included at concentrations of 100 to 200 microm , whereas carminomycin and 4-demethoxydaunorubicin produced equivalent enhancement of peroxidation at lower concentrations of 30 to 50 microm . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
13,
25
]
} | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
192,
215
]
} |
either the surface charge due to membrane lipids does not influence inactivation or the lipids immediately surrounding the na channel are restricted in their mobility . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
33,
48
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
88,
94
]
} |
individual , isolated retzius cells in culture synthesized [ 3h ] 5-ht from either [ 3h ] tryptophan or [ 3h ] 5-hydroxytryptophan [ ( 3h ] 5-htp ) . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
90,
100
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
140,
145
]
} |
neither pgi-2 ( 10 micrograms/h ) nor 6-keto pgf-1 alpha ( 10 or 100 micrograms/h ) had any significant effect on plasma concentrations of 20 alpha-dihydroprogesterone or on luteal tissue concentrations of pregnenolone , progesterone or 20 alpha-dihydroprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
155,
167
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
237,
239
]
} |
anti-mullerian activity of testicular tissue , immunoreactive testicular amh , serum amh concentration and amh production by incubated testicular tissue were detectable from 42 days , i.e . at the time of seminiferous tubule differentiation , and peaked between 50 and 80 days , when the mullerian ducts regress in the male fetus . | NA | {
"id": "C0039586",
"name": "testicular amh",
"pos": [
62,
76
]
} | {
"id": "C0066928",
"name": "amh",
"pos": [
107,
110
]
} |
when [ 3h ] progesterone is infused intravenously into ewes , blood 20 alpha-dihydroprogesterone ( 20 alpha-dihp ) becomes labelled and the changes in [ 3h ] 20 alpha-dihp activity with time are clearly related to that of [ 3h ] progesterone . | NA | {
"id": "C0012311",
"name": "20",
"pos": [
68,
70
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
229,
241
]
} |
prostaglandin synthesis by , and the effects of prostaglandins and prostaglandin analogues on , the vas deferens of the rabbit and rat in vitro . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
48,
62
]
} | {
"id": "C0033568",
"name": "prostaglandin",
"pos": [
67,
80
]
} |
however comparison of a total of 20 sialograms obtained from patients with antibodies to ss-a ( ro ) showed more advanced changes than in a total of 36 sialograms from patients without antibodies to ss-a ( ro ) in systemic lupus erythematosus , mixed connective tissue disease , progressive systemic sclerosis and rheumatoid arthritis . | NA | {
"id": "C1527336",
"name": "ss-a",
"pos": [
89,
93
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
314,
334
]
} |
it is proposed that crp , an acute phase protein , may play a role in the pathogenesis of gouty arthritis attacks occurring in some patients following surgery or acute physical illness . | NA | {
"id": "C0006560",
"name": "crp",
"pos": [
20,
23
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
29,
48
]
} |
blood and serum concentrations of gold after a single dose of auranofin in children with juvenile rheumatoid arthritis . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
62,
71
]
} |
studies of a first ( trial ) set of barbiturates related to pentobarbital revealed a region of space in which at least one low-energy conformation of the hydrocarbon side chain of each of the anticonvulsant barbiturates resides . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
60,
73
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
207,
219
]
} |
a liquid membrane anion-sensitive electrode responds reproducibly to a wide range of carboxylate and sulfonate ions . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
18,
23
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
111,
115
]
} |
rna1 and rna2 ( the transcripts initiated from p1 and p2 , respectively ) and rna3 ( an rna-processing intermediate containing the entire 5 s region and the 3 ' end of the transcripts ) can be cleaved in vitro by cell extracts of wild type strains resulting in precursor and mature 5 s rrnas in a reaction that is rnase e dependent but not ribosome dependent . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035701",
"name": "rrnas",
"pos": [
286,
291
]
} |
the motion of the atoms in the small protein bovine pancreatic trypsin inhibitor has been simulated for about 60 picoseconds using two different potential energy functions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0003641",
"name": "bovine pancreatic trypsin inhibitor",
"pos": [
45,
80
]
} |
the 132 picosecond simulation of atomic motion in bovine pancreatic trypsin inhibitor protein generated in the accompanying paper is analysed here using a variety of different methods . | NA | {
"id": "C0003641",
"name": "bovine pancreatic trypsin",
"pos": [
50,
75
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
86,
93
]
} |
analysis of homologous dna regions derived from two different strains of d. melanogaster containing f elements ( filled sites ) or lacking f elements ( empty sites ) showed that f insertions lead to the generation of target site duplications of 8 to 13 base-pairs . | NA | {
"id": "C0016330",
"name": "f elements",
"pos": [
100,
110
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
243,
244
]
} |
the solution proton nuclear magnetic resonance spectrum of the met-cyano form of sperm whale myoglobin reveals the presence of two sets of comparably intense resonances immediately after reacting the apoprotein with hemin , only one of which corresponds to that of the accepted native protein . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
200,
210
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
285,
292
]
} |
this phenomenon , observed earlier only for myoglobin with modified hemin , dictates that the second protein component in solution immediately after reconstitution must have the heme rotated by 180 degrees about the alpha-gamma-meso axis as compared to that found in the single crystal . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
68,
73
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
178,
182
]
} |
we have examined the phylogenetic distribution of a spectrum of drosophila repetitive-dispersed dnas ranging from structurally complex transposable elements to scrambled middle repetitive sequences . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
96,
100
]
} | {
"id": "C0012868",
"name": "transposable",
"pos": [
135,
147
]
} |
brain dopamine ( da ) , norepinephrine ( ne ) , epinephrine ( e ) , and serotonin ( 5-ht ) were measured by radioenzymatic assays . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
24,
38
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} |
the animals were sacrificed 4 , 7 , 12 , and 18 days after the inoculation , and the cns contents of dopamine , norepinephrine , and adrenaline were determined by a radioenzymatic method . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
133,
143
]
} |
acetone , ethanol , isopropanol , and methanol in increasing concentrations produced a linear increase in fpd osmolality , but no change in vp osmolality . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
10,
17
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
20,
31
]
} |
acetone , ethanol , isopropanol , and methanol in increasing concentrations produced a linear increase in fpd osmolality , but no change in vp osmolality . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
10,
17
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
38,
46
]
} |
morbidity of chronic hepatitis b infection in s. mansoni infected persons appears to be unusually severe compared with hepatitis b infection in other populations . | NA | {
"id": "C0524909",
"name": "chronic",
"pos": [
13,
20
]
} | {
"id": "C0019163",
"name": "hepatitis b infection",
"pos": [
119,
140
]
} |
hence , the 47,000-dalton carboxy-terminal sequences of the transforming proteins of these viruses and of the cellular gene product are probably highly conserved but may contain single amino acid substitutions . | NA | {
"id": "C0042736",
"name": "proteins",
"pos": [
73,
81
]
} | {
"id": "C0033684",
"name": "gene product",
"pos": [
119,
131
]
} |
t1 oligonucleotide mapping of mh2 rna indicated that the mh2 v-myc sequences map close to the 3 ' end of viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
34,
37
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
105,
114
]
} |
considerable uncertainty surrounds the selection of test values that separate infertile from fertile men in the evaluation of male infertility . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
78,
87
]
} | {
"id": "C0021364",
"name": "male infertility",
"pos": [
126,
142
]
} |
this method of analyzing infertility test results provides insight into the potential causes of male infertility and offers a critical approach towards understanding the complex problem of male fertility dysfunction . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
25,
36
]
} | {
"id": "C0021364",
"name": "male infertility",
"pos": [
96,
112
]
} |
previously we evaluated new methods to localize the source of bacteriuria in monkeys with experimental urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
62,
73
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
103,
126
]
} |
the recent development of hybridoma technology has made it possible to obtain large quantities of antibody against a single determinant ( monoclonal antibodies ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
98,
106
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
138,
148
]
} |
in 1 system , the fibroblasts proliferated as anchored cells beneath the agarose , and in the other the fibroblasts were nongrowing cells embedded within the agarose as nonanchored cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
181,
186
]
} |
in contrast to the largely inhibitory effects of anchored fetal fibroblasts on tumor cell growth , their nonanchored counterparts were exclusively stimulatory . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
85,
89
]
} |
further experiments modulating the growth rate of neonatal fibroblasts with fetal bovine serum have indicated that the diverse tumor responses elicited by anchored versus nonanchored cells , as well as those observed for the aged bladder fibroblasts , were a function of fibroblast growth rate . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
183,
188
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
271,
281
]
} |
none of the 49 infants who were tested prior to receipt of mmr vaccine had antibody against any of these viruses , indicating that the antibody found after immunization was unlikely to be due to false-positive results . | NA | {
"id": "C0003253",
"name": "antibody",
"pos": [
75,
83
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
135,
143
]
} |
when the following 7 risk factors were actively managed in the acute stage of myocardial infarction , the incidence of myocardial rupture was significantly reduced : a ) high blood pressure on admission , b ) physical and emotional instability , c ) recurrent chest pain , d ) aged females , e ) no history of angina or myocardial infarction , f ) large myocardial infarction on ecg and g ) the first 10 days after the attack of myocardial infarction . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
260,
270
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
310,
316
]
} |
they often had life-threatening arrhythmias during attacks ( 8 ventricular tachycardia or ventricular fibrillation , 8 serious bradyarrhythmia ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
32,
43
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
90,
114
]
} |
the surgical mortality rates were 4 % for cases of ventricular septal defect associated with pulmonary hypertension in patients under 2 years of age , 16.7 % for complete atrio-ventricular canal , 11 % for coarctation of the aorta associated with ventricular septal defect , 40 % for pure pulmonary atresia without ebstein anomaly , 44 % for total anomalous pulmonary venous return , 14.8 % for transposition of the great arteries , 44 % for double outlet right ventricle and 1.1 % for tetralogy of fallot . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
395,
430
]
} | {
"id": "C0013069",
"name": "double outlet right ventricle",
"pos": [
442,
471
]
} |
in the cases of myelocytic leukemia , the distance of random migration was on the average 0.54 mm for the cells of five patients with acute myelocytic leukemia , 2.42 mm for the cells of three patients with acute myelomonocytic leukemia , 1.69 mm for the cells of four patients with chronic myelocytic leukemia at blastic crisis and 3.78 mm for the cells of one patient with chronic monocytic leukemia . | NA | {
"id": "C0023470",
"name": "myelocytic leukemia",
"pos": [
16,
35
]
} | {
"id": "C0023479",
"name": "acute myelomonocytic leukemia",
"pos": [
207,
236
]
} |
in the cases of myelocytic leukemia , the distance of random migration was on the average 0.54 mm for the cells of five patients with acute myelocytic leukemia , 2.42 mm for the cells of three patients with acute myelomonocytic leukemia , 1.69 mm for the cells of four patients with chronic myelocytic leukemia at blastic crisis and 3.78 mm for the cells of one patient with chronic monocytic leukemia . | NA | {
"id": "C0023470",
"name": "myelocytic leukemia",
"pos": [
16,
35
]
} | {
"id": "C0023473",
"name": "chronic myelocytic leukemia",
"pos": [
283,
310
]
} |
[ b. enzymatic analysis of sialic acids and clinical application . 1. comparison of the blood serum-sialic acid level and erythrocyte sedimentation rate ] . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
27,
39
]
} | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
100,
111
]
} |
we analyzed 10 clones from cell line os-513 , which has originated from a bk virus-induced hamster osteosarcoma and contains only free defective viral dna , for viral dna by electrophoresis followed by blot hybridization . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
161,
170
]
} |
the analysis of the activity by deae-cellulose column chromatography revealed that estrogen had no effect on increases in the levels in both types i and ii camp-dependent protein kinases , on the basis of mg protein , while progesterone produced a 50 % decrease in type i camp-dependent protein kinase and a 50 % increase in type ii camp-dependent protein kinase . | NA | {
"id": "C0010531",
"name": "camp-dependent protein",
"pos": [
156,
178
]
} | {
"id": "C1956039",
"name": "type i camp-dependent protein kinase",
"pos": [
265,
301
]
} |
the analysis of the activity by deae-cellulose column chromatography revealed that estrogen had no effect on increases in the levels in both types i and ii camp-dependent protein kinases , on the basis of mg protein , while progesterone produced a 50 % decrease in type i camp-dependent protein kinase and a 50 % increase in type ii camp-dependent protein kinase . | NA | {
"id": "C0010531",
"name": "camp-dependent protein",
"pos": [
156,
178
]
} | {
"id": "C0033639",
"name": "type ii",
"pos": [
325,
332
]
} |
in helically-cut strips of cerebral arteries isolated from dogs , serotonin , tryptamine , 5-hydroxytryptophan and tryptophan caused a dose-related contraction . | NA | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
91,
110
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
115,
125
]
} |
the potency was in the order of serotonin greater than tryptamine much greater than 5-hydroxytryptophan = tryptophan . | NA | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
86,
103
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
106,
116
]
} |
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