text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we infer from the experimental results that electrostatic binding between cationic anesthetics and anionic phosphate of phospholipids produced the constrained component . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
99,
106
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
107,
116
]
} |
reconstituted cells were constructed by fusion of cytoplasts from the human diploid fibroblast cell strain detroit 532 and karyoplasts from the mouse fibroblast cell line a9 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
150,
160
]
} |
previous work has shown that the presence of a phorbol ester tumor promoter , phorbol 12-myristate 13-acetate ( pma ) , during a single-step selection for methotrexate ( mtx ) -resistant mouse 3t6 cells results in an up to 100-fold increase in the incidence of mtx-resistant , colony-forming cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
47,
60
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
78,
85
]
} |
comparative studies with human alpha , beta , and gamma interferons indicated that sensitivity to htnf and interferon can be distinguished . | NA | {
"id": "C0021745",
"name": "gamma interferons",
"pos": [
50,
67
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
107,
117
]
} |
[ 3h ] cholesterol ethers , which can not be hydrolyzed or mobilized after uptake , were incorporated into the lipid core of reconstituted hdl to reflect the fate of the cholesterol esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
7,
18
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
170,
188
]
} |
the level in monosomic 21 cells was 70 % of this value and the level in fibroblasts from down syndrome patients was about 2 times higher than normal . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} |
glicentin is followed by two additional glucagon-like peptides , each flanked by paired basic amino acids ( lys , arg ) characteristic of prohormone processing . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
88,
105
]
} | {
"id": "C0024337",
"name": "lys",
"pos": [
108,
111
]
} |
a small percentage of delta-globin transcripts appeared to be initiated upstream from the normal initiation site . beta-globin mrna was not detected in any studies . | NA | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
22,
34
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
115,
126
]
} |
thus , e. coli contains sequences , which in `` '' natural '' '' negatively supercoiled dna , adopt a left-handed z-dna-like conformation . | NA | {
"id": "C0012854",
"name": "d d",
"pos": [
86,
89
]
} | {
"id": "C0043442",
"name": "left-hand",
"pos": [
102,
111
]
} |
we have developed a procedure for simultaneous flow cytometric measurement of cellular dna content and amount of brdurd incorporated into cellular dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
147,
150
]
} |
at the end of the preincubation period , wild-type cells were cholesterol replete while mutant cells that could not utilize the cholesterol in ldl were cholesterol deficient . | NA | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
62,
73
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
152,
163
]
} |
fetal sheep serum-to-fetal calf serum transfers resulted in significant decrease in hb f synthesis , revealing an interaction between hemoglobin switching activity and cells at an early stage of progenitor cell development . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
84,
88
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
134,
144
]
} |
maximal decrease in hb f synthesis was observed in fetal sheep serum-to-fetal sheep serum transfers , indicating that optimal effects on hb switching are obtained when the environment that induces hb switching is present throughout the development of progenitor cells . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
20,
24
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
197,
199
]
} |
selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay , in which the functional receptor is the delta receptor , versus the guinea pig ileum assay , in which the mu receptor is the functional receptor , and by determining t... | NA | {
"id": "C0034801",
"name": "opioid receptor",
"pos": [
53,
68
]
} | {
"id": "C0140057",
"name": "delta receptor",
"pos": [
373,
387
]
} |
selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay , in which the functional receptor is the delta receptor , versus the guinea pig ileum assay , in which the mu receptor is the functional receptor , and by determining t... | NA | {
"id": "C0034801",
"name": "opioid receptor",
"pos": [
53,
68
]
} | {
"id": "C0066908",
"name": "mu receptor",
"pos": [
447,
458
]
} |
time-resolved phosphorescence anisotropy measurements with anti-h-2kk antibodies labeled with eosin or erythrosin yielded rotational mobility information for the antigen-antibody complexes on the cell membrane . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
70,
80
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
162,
188
]
} |
genetic mapping of a human class ii antigen beta-chain cdna clone to the sb region of the hla complex . | NA | {
"id": "C0019754",
"name": "human class ii antigen",
"pos": [
21,
43
]
} | {
"id": "C0019759",
"name": "sb",
"pos": [
73,
75
]
} |
in the presence of 1 microm of the synthetic glucocorticoid ru26988 ( 11 beta , 17 beta-dihydroxy-17 alpha-propynylandrost-1,4,6 , -trien-3-one ) to exclude tracer from [ 3h ] dex sites , hippocampal cytosol from adrenalectomized/ovariectomized sprague-dawley rats binds [ 3h ] dex to sites ( kd at 4 degrees c , 0.77 x ... | NA | {
"id": "C0016280",
"name": "9",
"pos": [
64,
65
]
} | {
"id": "C0020268",
"name": "cortisol",
"pos": [
529,
537
]
} |
no cross-reactive material was observed in the cells or in secretions from the fibroblasts of the affected dogs . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} |
taken together with our present results , which fail to provide evidence for increased secretion of apolipoprotein b or de novo secretion of lipoproteins other than vldl that contain apolipoprotein b , it can be concluded that overproduction of ldl in rabbits lacking ldl receptors is solely the result of altered metabo... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
141,
153
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
328,
332
]
} |
effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
89,
109
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
114,
135
]
} |
values for acetylcholinesterase and butyrylcholinesterase of superior cervical ganglia at 48 hr postdenervation were all considerably above those of denervated controls . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
11,
31
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
36,
57
]
} |
ligation of the external carotid and lingual arteries at 24 hr postdenervation was found to oppose the preservation of acetylcholinesterase and butyrylcholinesterase contents of the ganglia induced by barbiturate anesthesia . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
119,
139
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
144,
165
]
} |
the immunocytochemical staining patterns of 37 neuron-specific monoclonal antibodies previously described fell into four groups : ( i ) anti-synapse-associated , ( ii ) anti-neurofibrillar , ( iii ) anti-perikaryonal-neurofibrillar , and ( iv ) a single antibody reactive with a widely distributed epitope that covered t... | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
63,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
254,
262
]
} |
finally , brain opiate peptides , e.g . dynorphin , are very likely involved in the transmission of information concerned with the interaction of feeding and maintenance of energy balance . | NA | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
16,
31
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
40,
49
]
} |
the lymphocyte enzyme was stimulated by the potent beta-adrenergic catecholamine agonist isoproterenol and by the nonhydrolyzable gtp-analog gpp [ nh ] p . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
67,
80
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
89,
102
]
} |
the lymphocyte enzyme was stimulated by the potent beta-adrenergic catecholamine agonist isoproterenol and by the nonhydrolyzable gtp-analog gpp [ nh ] p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
130,
133
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
141,
153
]
} |
the plasma concentration of total glutathione ( gsh plus gssg ) , as determined by the glutathione reductase recycling method of tietze , decreased in all groups when plasma was allowed to stand in air at room temperature . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
48,
51
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
57,
61
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the ... | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
224,
233
]
} | {
"id": "C0087162",
"name": "vitamin b-6",
"pos": [
325,
336
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the ... | NA | {
"id": "C0034268",
"name": "pyridoxamine",
"pos": [
255,
267
]
} | {
"id": "C0087162",
"name": "vitamin b-6",
"pos": [
325,
336
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the ... | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
389,
398
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
410,
416
]
} |
there were no significant differences between the absorption rates of b-6 vitamers from control and test solutions containing cellulose , pectin , and lignin . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
126,
135
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
151,
157
]
} |
eca treated with pf no longer modifies erythrocytes for agglutination by eca antibodies and exerts less antibody-neutralizing capacity than untreated antigen . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} | {
"id": "C0475463",
"name": "antibody-neutralizing",
"pos": [
104,
125
]
} |
epithelioid ( hela ) and fibroblastic ( l ) cells in culture incubated for 18 hr with the ionophores amphotericin b and amiloride were noted to bind significantly more and less bacteria , respectively , than control cells incubated without ionophores . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
25,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
the effects of leukotriene d4 ( ltd4 ) , a component of the slow reacting substance of anaphylaxis ( srs-a ) , and the putative srs-a antagonist fpl 55712 were studied on cerebral arteries in vivo and in vitro . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
15,
29
]
} | {
"id": "C0038091",
"name": "srs-a",
"pos": [
128,
133
]
} |
these results show sct can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain . | NA | {
"id": "C0073994",
"name": "sct",
"pos": [
19,
22
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
131,
141
]
} |
the neutral amino acids are subsequently placed on a dowex-50 column from which potassium acetate buffers are used to separate the amido amino acids , gaba and the other neutral amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
12,
23
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
170,
189
]
} |
agonistic action of a benzodiazepine antagonist : effects of ro 15-1788 and midazolam on hypertonic nacl intake . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
22,
36
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
76,
85
]
} |
it is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs ( diazepam , clonazepam , na phenobarbital , primidone , carbamezepine , ethosuximide , diphenylhydantoin , na valproate , gabob ) show an activity which is does-dependent and within a range s... | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
157,
170
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
173,
182
]
} |
the antagonism between strychnine and atropine may be explained taking into account the presynaptic action of atropine and the antagonism between strychnine and pentobarbital is in agreement with a gabaergic action of the barbiturates . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
161,
174
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
222,
234
]
} |
calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
28,
37
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
42,
52
]
} |
in isolated and enriched guinea pig parietal cells the inhibitory effects of the calcium channel antagonists verapamil and gallopamil on 14c-aminopyrine uptake ( = h+ secretion ) have been analyzed . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
109,
118
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
123,
133
]
} |
both verapamil and gallopamil inhibit acid secretion in a concentration-dependent manner with an ic50 of 12.1 and 10.9 mumol/l respectively . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
5,
14
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
19,
29
]
} |
it is concluded that the calcium channel antagonists verapamil and gallopamil inhibit acid secretion in vitro by interfering with the parietal cell proton pump , the k+/h+-atpase . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
53,
62
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
67,
77
]
} |
the present study , using displacement by epinephrine , norepinephrine , isoproterenol and clonidine validated the use of these radioligands as appropriate for specific receptor binding in pancreatic islet cells . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} |
many nuclear proteins are phosphorylated : they range from enzymes to several structural proteins such as histones , non-histone chromosomal proteins and the nuclear lamins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
5,
21
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
106,
114
]
} |
many nuclear proteins are phosphorylated : they range from enzymes to several structural proteins such as histones , non-histone chromosomal proteins and the nuclear lamins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
5,
21
]
} | {
"id": "C0008600",
"name": "non-histone chromosomal proteins",
"pos": [
117,
149
]
} |
work on the phosphorylation of proteins as a dynamic process involved in the regulation of biological processes started in the 1950s with the finding that phosphorylase a and phosphorylase b are phospho and dephospho forms of the same enzyme . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
155,
168
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
175,
190
]
} |
another common technique is prolonged monitoring of the patient 's electroencephalogram ( eeg ) by radiotelemetry , during which time the patient is closely observed by trained personnel for suspected seizures.to compare the quality of information obtained from intensive monitoring with that from careful routine electr... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
201,
209
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
567,
575
]
} |
the intensity of the red fluorescence ( from single-stranded dna ) divided by the green fluorescence ( from double-stranded dna ) was used as a measured of dna strand breaks . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
45,
64
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
108,
127
]
} |
the relative sensitivities of a human diploid fibroblast strain ( ag1522 ) and an established line of contact-inhibited mouse embryo fibroblasts ( 10t1/2 ) were compared after incorporation of [ 3h ] thymidine or [ 125i ] iododeoxyuridine into the cellular dna and growth at 37 degrees c . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
248,
256
]
} |
whereas these cells show similar sensitivities to acute x irradiation , the d0 for clonal survival of the mouse fibroblasts was 5- to 10-fold higher than the d0 for the human fibroblasts for both 3h and 125i . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
175,
186
]
} |
no distinctions were observed in the character and manifestation of disturbances of the lymphocyte migration after the injection of 35s-methionine and gamma-emitter , 75se-selenomethionine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
136,
146
]
} | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
172,
188
]
} |
the ratio of the tritium content per 1 m hydrogen of dna to tritium content per 1 m hydrogen of tissue water increased up to 0.5-0.7 during the uptake of tritium oxide , and up to 4-7 after the administration of the isotope had ceased . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
17,
24
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
84,
92
]
} |
ct-derived cross sections were correlated with age , height , weight , and body-surface area , and they were compared with findings of published clinical and post-mortem studies . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
62,
68
]
} | {
"id": "C0037088",
"name": "findings",
"pos": [
123,
131
]
} |
monoclonal antibodies have been applied as primary antibodies for the cellular and subcellular localisation of neuroactive substances . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} |
these data suggest that chronic haloperidol treatment and subsequent withdrawal results in the development of behavioural dopamine supersensitivity as well as biochemical alterations in dopaminergic and gabaergic system . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
122,
130
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
186,
198
]
} |
the effect of combined administration of l-dopa with apomorphine or with bromocriptine on rat striatal concentrations of dopamine ( da ) , dihydroxyphenylacetic ( dopac ) and dopa was investigated . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
41,
47
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
175,
179
]
} |
the dopa-induced elevations in striatal concentrations of da , dopac and dopa were similar among animals injected with l-dopa alone or in combination with apomorphine or bromocriptine . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
4,
8
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
119,
125
]
} |
prostaglandin ( pge , 6-keto pgf1 alpha ) output by cells dispersed from human amnion and decidua in the presence of increasing levels ( 0-5000 ng/ml ) of estradiol-17 beta ( e2 ) or 2-hydroxyestradiol-17 beta ( 2-oh e2 ) was studied in relation to parturition . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
0,
13
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
16,
19
]
} |
biotransformation and pharmacokinetic studies should be undertaken to obtain better understanding of the chemical 's metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
117,
127
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
132,
141
]
} |
the authors study fast eeg rhythms in amino acidopathies of the newborn and in progressive encephalopathy of the central nervous system in children , when an inborn error of metabolism has either been found or is suspected . | NA | {
"id": "C0002514",
"name": "amino acidopathies",
"pos": [
38,
56
]
} | {
"id": "C0025521",
"name": "inborn error of metabolism",
"pos": [
158,
184
]
} |
in the first group : amino acidopathies ( including phenylketonuria ) , fast rhythms on the eeg of the neonates are of low amplitude , spindle-like bursts of 7-13 hz and usually located in rolandic areas . | NA | {
"id": "C0002514",
"name": "amino acidopathies",
"pos": [
21,
39
]
} | {
"id": "C0031485",
"name": "phenylketonuria",
"pos": [
52,
67
]
} |
[ hyperinsulinism and insulin resistance diagnosed by oral and intravenous glucose loading and by the tolbutamide test in polycystic ovary syndrome ] . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
2,
17
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
22,
40
]
} |
confluent cultures of rat glomerular epithelial and mesangial cells were studied by immunofluorescent microscopy , using affinity-purified antibodies directed against collagen of type i-v or an antiserum directed against a basement membrane ( bm ) proteoglycan . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
139,
149
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
194,
203
]
} |
plasma from fasted ( as well as fed ) diabetics contained supranormal concentrations of several amino acids , including the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
96,
107
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
124,
150
]
} |
parallelly , lipid ( triglyceride and cholesterol ) and lipoprotein ( high-density/hdl/ , low-density/ldl/ , and very-low-density/vldl/ ) content in ascites and pleural effusions , were determined . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
56,
67
]
} |
there were similar changes in the cholesterol content of these lipoprotein fractions , i.e. , an increase of vldl- and a decrease of hdl- and ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
34,
45
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
142,
157
]
} |
although a yersinia infection has not been formally established as the cause , there is some indirect evidence pointing to the reality of systemic yersinia pseudotuberculosis infection . | NA | {
"id": "C0043407",
"name": "yersinia infection",
"pos": [
11,
29
]
} | {
"id": "C0043410",
"name": "yersinia pseudotuberculosis infection",
"pos": [
147,
184
]
} |
sjogren 's syndrome in systemic lupus erythematosus and rheumatoid arthritis : immune effector cells in salivary glands . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
0,
19
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
56,
76
]
} |
in secondary ( 2 degrees ) ss in cases of systemic lupus erythematosus ( sle ) and rheumatoid arthritis , respectively , 55 % +/- 4 % ( range 41-69 ) and 43 % +/- 7 % ( range 15-80 ) of all inflammatory cells in the periductal lymphocyte-rich infiltrates were t-pattern lymphocytes . | NA | {
"id": "C1527336",
"name": "ss",
"pos": [
27,
29
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
83,
103
]
} |
to determine the clinical significance of anti-centromere ( aca ) and anti scl-70 antibodies in an english population with connective tissue diseases , we examined the sera of 150 patients , including 40 with systemic sclerosis ( ss ) , who were prospectively studied on the same clinical protocol in our connective tiss... | NA | {
"id": "C0036421",
"name": "systemic sclerosis",
"pos": [
209,
227
]
} | {
"id": "C0009782",
"name": "connective tissue",
"pos": [
305,
322
]
} |
anti scl-70 was detected in 20 % of the patients with ss and only two of those with other connective tissue diseases . | NA | {
"id": "C0036421",
"name": "ss",
"pos": [
54,
56
]
} | {
"id": "C0009782",
"name": "of",
"pos": [
70,
72
]
} |
however , the cholesterol ratio ( hdl cholesterol x 100/ldl + vldl cholesterol ) was not influenced by posture and should be evaluated instead of cholesterol fractions if the conditions for blood sampling were not controlled . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
34,
49
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
146,
157
]
} |
stone materials differ in weight distribution , and reports of composition in different weight ranges may facilitate comparison and compensate for bias in selection of stones for analysis . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
26,
32
]
} | {
"id": "C0005911",
"name": "different weight",
"pos": [
78,
94
]
} |
there were four perinatal deaths , of which two were stillbirths , further 3 infants died later as a result of abuse or neglect . | NA | {
"id": "C0701826",
"name": "perinatal deaths",
"pos": [
16,
32
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
85,
89
]
} |
as laboratory parameters , lipids , lipoproteins ( vldl , idl , ldl , hdl2 and hdl3 by rate zonal centrifugation ) and the percentage composition of the major apolipoproteins in vldl , hdl2 and hdl3 , as well as lipoprotein lipase ( lpl ) , hepatic lipase ( htgl ) and lecithin-cholesterol-acyl-transferase ( lcat ) were... | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
27,
33
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
162,
174
]
} |
much remains to be understood of the mechanisms of ebv infections , which in some geographic areas lead to inapparent infections and in others to burkitt lymphoma or nasopharyngeal carcinoma , while in temperate regions the clinical manifestations are those of infectious mononucleosis . | NA | {
"id": "C0149678",
"name": "ebv infections",
"pos": [
51,
65
]
} | {
"id": "C0006413",
"name": "burkitt lymphoma",
"pos": [
146,
162
]
} |
binding and inactivation of isotopically labeled porcine pancreatic elastase and human neutrophil elastase by alpha 1-protease inhibitor were measured in fluid obtained by bronchoalveolar lavage of volunteers . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
57,
76
]
} | {
"id": "C0064833",
"name": "neutrophil elastase",
"pos": [
87,
106
]
} |
moxalactam has little , if any , interactions with penicillinases , as is also the case of cefoxitin , cefuroxime and cefotaxime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
103,
113
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} |
moxalactam elimination kinetics are linear , independent from the dose and route of administration , with a distribution half-life ( t 1/2 alpha ) between 0.20 and 0.60 hours and an elimination half-life ( t 1/2 beta ) between 2 and 2.5 hours ( range : 1.9 and 3.1 hours ) . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
23,
31
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
194,
203
]
} |
the distribution and incidence of the spinal and extraspinal hyperostosis in this series corresponds closely to the findings in diffuse idiopathic skeletal hyperostosis ( dish ) . | NA | {
"id": "C0020492",
"name": "hyperostosis",
"pos": [
61,
73
]
} | {
"id": "C0020498",
"name": "diffuse idiopathic skeletal hyperostosis",
"pos": [
128,
168
]
} |
in western countries two common and successful measures employed to combat nutritional deficiencies and deficiency diseases are : ( i ) enrichment of refined cereal products with nutrients lost during milling ; | NA | {
"id": "C0162429",
"name": "nutritional deficiencies",
"pos": [
75,
99
]
} | {
"id": "C0011156",
"name": "deficiency diseases",
"pos": [
104,
123
]
} |
the prolonged administration of epsilon-aminocaproic acid ( eaca ) resulted in the development of severe proximal myopathy associated with high plasma creatine kinase values , rhabdomyolysis , myoglobinuria , and mild hyperbilirubinaemia . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
176,
190
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
193,
206
]
} |
one died on day 3 of low-output syndrome and the other had rapidly progressive nephrosclerosis and died of that disease one year later . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
32,
40
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
112,
119
]
} |
we attempted to examine procoagulant activity ( pca ) , x activator activity ( xaa ) and plasminogen activator activity ( plgaa ) of various leukemic cell lysates : 17 acute myelocytic leukemias ( aml ) , 4 acute promyelocytic leukemias ( apl ) , 9 acute myelomonocytic leukemias ( ammol ) , 7 chronic myelocytic leukemi... | NA | {
"id": "C0023467",
"name": "acute myelocytic leukemias",
"pos": [
168,
194
]
} | {
"id": "C0023487",
"name": "acute promyelocytic leukemias",
"pos": [
207,
236
]
} |
among those 70 cases , 4 apl , 4 ammol and 5 aml were associated with overt disseminated intravascular coagulation ( dic ) and 5 t cell all , 7 atl and 2 null cell all were associated with hypofibrinogenemia not adapted for dic . | NA | {
"id": "C0023487",
"name": "apl",
"pos": [
25,
28
]
} | {
"id": "C0023467",
"name": "aml",
"pos": [
45,
48
]
} |
apl and aml , especially those associated with overt dic , had high pca , and lymphocytic leukemia generally had low pca in comparison with normal controls . | NA | {
"id": "C0023487",
"name": "apl",
"pos": [
0,
3
]
} | {
"id": "C0023467",
"name": "aml",
"pos": [
8,
11
]
} |
a rapid and highly sensitive solid phase assay was compared with the fibrin plate method for the measurement of urokinase , streptokinase and the plasminogen activators in human euglobulin fractions . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
124,
137
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
146,
157
]
} |
isolation and anticoagulant properties of a new sulfated xylan : comparison with heparin and a sodium pentosan polysulfate ( sp-54 ) . | NA | {
"id": "C0030888",
"name": "sulfated xylan",
"pos": [
48,
62
]
} | {
"id": "C0524684",
"name": "sodium pentosan polysulfate",
"pos": [
95,
122
]
} |
plasma is incubated with cellulose-antibody for 2 hours , fluorescent-labelled antiserum is added and the samples are allowed to react for an additional 2 hours . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
35,
43
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
79,
88
]
} |
the cellulose-antibody reagent and the fluorescent-labelled antiserum were both stable over a period of 1 year , demonstrating a major advantage of fluoroimmunoassay over radioimmunoassay . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
60,
69
]
} |
in adrenaline and noradrenaline ( 10 ( -8 ) -10 ( -5 ) g/ml ) , the ijp could be evoked in spite of a hyperpolarization of the cell membrane . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
3,
13
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} |
since a single po dose of methaqualone failed to produce any alteration in the rate of metabolism of acetylsalicylic acid , procaine , p-nitrophenylacetate , acetanilid , and butyrylcholine within 20 hr , it may be interpreted that the stimulation of acetylsalicylic acid and acetanilid metabolism is possibly due to sel... | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
361,
368
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
369,
377
]
} |
the absorption , distribution , excretion , and metabolism of a single oral dose of o-ethyl o-4-nitrophenyl phenylphosphonothioate in hens . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
48,
58
]
} |
acute ethanol intake diminished liver gsh content by 30 % and enhanced that of gssg by 73 % , thus eliciting a net decrease of 20 % in total gsh equivalents ( gsh + 2gssg ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
79,
83
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
159,
162
]
} |
the combined administration of iron and ethanol further influenced the decrease in hepatic gsh and the increase in gssg levels elicited by the separate treatments , but no alterations in the biliary content and release of total gsh were observed in this situation . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
115,
119
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
228,
231
]
} |
fischer 344 rats were fed semi-purified rations containing 20 % w/w corn that was either free of aflatoxin or naturally contaminated with 880 micrograms/kg total aflatoxin and was either treated with ammonia gas or was not treated . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
200,
207
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
208,
211
]
} |
smaller amounts of some of the esters caused a characteristic chronic lung lesion , with proliferation of alveolar tissue , resembling that produced by the pyrrolizidine alkaloids fulvine and monocrotaline . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloids",
"pos": [
156,
179
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
192,
205
]
} |
the response criteria developed in experimental radiotherapy of mouse tumours are applicable to human tumour response , too . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
35,
47
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
102,
108
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.