text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we infer from the experimental results that electrostatic binding between cationic anesthetics and anionic phosphate of phospholipids produced the constrained component . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
99,
106
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
107,
116
]
} |
reconstituted cells were constructed by fusion of cytoplasts from the human diploid fibroblast cell strain detroit 532 and karyoplasts from the mouse fibroblast cell line a9 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
150,
160
]
} |
previous work has shown that the presence of a phorbol ester tumor promoter , phorbol 12-myristate 13-acetate ( pma ) , during a single-step selection for methotrexate ( mtx ) -resistant mouse 3t6 cells results in an up to 100-fold increase in the incidence of mtx-resistant , colony-forming cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
47,
60
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
78,
85
]
} |
comparative studies with human alpha , beta , and gamma interferons indicated that sensitivity to htnf and interferon can be distinguished . | NA | {
"id": "C0021745",
"name": "gamma interferons",
"pos": [
50,
67
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
107,
117
]
} |
[ 3h ] cholesterol ethers , which can not be hydrolyzed or mobilized after uptake , were incorporated into the lipid core of reconstituted hdl to reflect the fate of the cholesterol esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
7,
18
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
170,
188
]
} |
the level in monosomic 21 cells was 70 % of this value and the level in fibroblasts from down syndrome patients was about 2 times higher than normal . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} |
glicentin is followed by two additional glucagon-like peptides , each flanked by paired basic amino acids ( lys , arg ) characteristic of prohormone processing . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
88,
105
]
} | {
"id": "C0024337",
"name": "lys",
"pos": [
108,
111
]
} |
a small percentage of delta-globin transcripts appeared to be initiated upstream from the normal initiation site . beta-globin mrna was not detected in any studies . | NA | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
22,
34
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
115,
126
]
} |
thus , e. coli contains sequences , which in `` '' natural '' '' negatively supercoiled dna , adopt a left-handed z-dna-like conformation . | NA | {
"id": "C0012854",
"name": "d d",
"pos": [
86,
89
]
} | {
"id": "C0043442",
"name": "left-hand",
"pos": [
102,
111
]
} |
we have developed a procedure for simultaneous flow cytometric measurement of cellular dna content and amount of brdurd incorporated into cellular dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
147,
150
]
} |
at the end of the preincubation period , wild-type cells were cholesterol replete while mutant cells that could not utilize the cholesterol in ldl were cholesterol deficient . | NA | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
62,
73
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
152,
163
]
} |
fetal sheep serum-to-fetal calf serum transfers resulted in significant decrease in hb f synthesis , revealing an interaction between hemoglobin switching activity and cells at an early stage of progenitor cell development . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
84,
88
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
134,
144
]
} |
maximal decrease in hb f synthesis was observed in fetal sheep serum-to-fetal sheep serum transfers , indicating that optimal effects on hb switching are obtained when the environment that induces hb switching is present throughout the development of progenitor cells . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
20,
24
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
197,
199
]
} |
selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay , in which the functional receptor is the delta receptor , versus the guinea pig ileum assay , in which the mu receptor is the functional receptor , and by determining their relative abilities to displace the prototypical delta receptor ligand [ d-ala2 , d-leu5 ] enkephalin and the prototypical mu receptor ligand naloxone from rat brain membrane preparations . | NA | {
"id": "C0034801",
"name": "opioid receptor",
"pos": [
53,
68
]
} | {
"id": "C0140057",
"name": "delta receptor",
"pos": [
373,
387
]
} |
selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay , in which the functional receptor is the delta receptor , versus the guinea pig ileum assay , in which the mu receptor is the functional receptor , and by determining their relative abilities to displace the prototypical delta receptor ligand [ d-ala2 , d-leu5 ] enkephalin and the prototypical mu receptor ligand naloxone from rat brain membrane preparations . | NA | {
"id": "C0034801",
"name": "opioid receptor",
"pos": [
53,
68
]
} | {
"id": "C0066908",
"name": "mu receptor",
"pos": [
447,
458
]
} |
time-resolved phosphorescence anisotropy measurements with anti-h-2kk antibodies labeled with eosin or erythrosin yielded rotational mobility information for the antigen-antibody complexes on the cell membrane . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
70,
80
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
162,
188
]
} |
genetic mapping of a human class ii antigen beta-chain cdna clone to the sb region of the hla complex . | NA | {
"id": "C0019754",
"name": "human class ii antigen",
"pos": [
21,
43
]
} | {
"id": "C0019759",
"name": "sb",
"pos": [
73,
75
]
} |
in the presence of 1 microm of the synthetic glucocorticoid ru26988 ( 11 beta , 17 beta-dihydroxy-17 alpha-propynylandrost-1,4,6 , -trien-3-one ) to exclude tracer from [ 3h ] dex sites , hippocampal cytosol from adrenalectomized/ovariectomized sprague-dawley rats binds [ 3h ] dex to sites ( kd at 4 degrees c , 0.77 x 10 ( -9 ) m ; 65 fmol/mg of protein ) with the following order of specificity : aldosterone ( aldo ) = 9 alpha-fluorocortisol ( 9 alpha f-cortisol ) = deoxycorticosterone ( doc ) = corticosterone greater than cortisol much greater than dex ; | NA | {
"id": "C0016280",
"name": "9",
"pos": [
64,
65
]
} | {
"id": "C0020268",
"name": "cortisol",
"pos": [
529,
537
]
} |
no cross-reactive material was observed in the cells or in secretions from the fibroblasts of the affected dogs . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} |
taken together with our present results , which fail to provide evidence for increased secretion of apolipoprotein b or de novo secretion of lipoproteins other than vldl that contain apolipoprotein b , it can be concluded that overproduction of ldl in rabbits lacking ldl receptors is solely the result of altered metabolism of vldl . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
141,
153
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
328,
332
]
} |
effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
89,
109
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
114,
135
]
} |
values for acetylcholinesterase and butyrylcholinesterase of superior cervical ganglia at 48 hr postdenervation were all considerably above those of denervated controls . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
11,
31
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
36,
57
]
} |
ligation of the external carotid and lingual arteries at 24 hr postdenervation was found to oppose the preservation of acetylcholinesterase and butyrylcholinesterase contents of the ganglia induced by barbiturate anesthesia . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
119,
139
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
144,
165
]
} |
the immunocytochemical staining patterns of 37 neuron-specific monoclonal antibodies previously described fell into four groups : ( i ) anti-synapse-associated , ( ii ) anti-neurofibrillar , ( iii ) anti-perikaryonal-neurofibrillar , and ( iv ) a single antibody reactive with a widely distributed epitope that covered the patterns of groups ii and iii . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
63,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
254,
262
]
} |
finally , brain opiate peptides , e.g . dynorphin , are very likely involved in the transmission of information concerned with the interaction of feeding and maintenance of energy balance . | NA | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
16,
31
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
40,
49
]
} |
the lymphocyte enzyme was stimulated by the potent beta-adrenergic catecholamine agonist isoproterenol and by the nonhydrolyzable gtp-analog gpp [ nh ] p . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
67,
80
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
89,
102
]
} |
the lymphocyte enzyme was stimulated by the potent beta-adrenergic catecholamine agonist isoproterenol and by the nonhydrolyzable gtp-analog gpp [ nh ] p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
130,
133
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
141,
153
]
} |
the plasma concentration of total glutathione ( gsh plus gssg ) , as determined by the glutathione reductase recycling method of tietze , decreased in all groups when plasma was allowed to stand in air at room temperature . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
48,
51
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
57,
61
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the same vitamin b-6 mixture and one of five fiber-rich test materials ( cellulose , pectin , lignin , homogenized fresh carrot , or carrot homogenized after 10 min boiling ) added at a concentration of 1-3 % . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
224,
233
]
} | {
"id": "C0087162",
"name": "vitamin b-6",
"pos": [
325,
336
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the same vitamin b-6 mixture and one of five fiber-rich test materials ( cellulose , pectin , lignin , homogenized fresh carrot , or carrot homogenized after 10 min boiling ) added at a concentration of 1-3 % . | NA | {
"id": "C0034268",
"name": "pyridoxamine",
"pos": [
255,
267
]
} | {
"id": "C0087162",
"name": "vitamin b-6",
"pos": [
325,
336
]
} |
to determine the effect of certain fiber materials on the absorption of b-6 vitamers , jejunal segments from young male adult rats were perfused in situ with a control solution containing 0.02 mm pyridoxine ( pn ) , 0.02 mm pyridoxal ( pl ) , and 0.02 mm pyridoxamine ( pm ) , followed by a test solution containing the same vitamin b-6 mixture and one of five fiber-rich test materials ( cellulose , pectin , lignin , homogenized fresh carrot , or carrot homogenized after 10 min boiling ) added at a concentration of 1-3 % . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
389,
398
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
410,
416
]
} |
there were no significant differences between the absorption rates of b-6 vitamers from control and test solutions containing cellulose , pectin , and lignin . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
126,
135
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
151,
157
]
} |
eca treated with pf no longer modifies erythrocytes for agglutination by eca antibodies and exerts less antibody-neutralizing capacity than untreated antigen . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} | {
"id": "C0475463",
"name": "antibody-neutralizing",
"pos": [
104,
125
]
} |
epithelioid ( hela ) and fibroblastic ( l ) cells in culture incubated for 18 hr with the ionophores amphotericin b and amiloride were noted to bind significantly more and less bacteria , respectively , than control cells incubated without ionophores . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
25,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
the effects of leukotriene d4 ( ltd4 ) , a component of the slow reacting substance of anaphylaxis ( srs-a ) , and the putative srs-a antagonist fpl 55712 were studied on cerebral arteries in vivo and in vitro . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
15,
29
]
} | {
"id": "C0038091",
"name": "srs-a",
"pos": [
128,
133
]
} |
these results show sct can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain . | NA | {
"id": "C0073994",
"name": "sct",
"pos": [
19,
22
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
131,
141
]
} |
the neutral amino acids are subsequently placed on a dowex-50 column from which potassium acetate buffers are used to separate the amido amino acids , gaba and the other neutral amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
12,
23
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
170,
189
]
} |
agonistic action of a benzodiazepine antagonist : effects of ro 15-1788 and midazolam on hypertonic nacl intake . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
22,
36
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
76,
85
]
} |
it is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs ( diazepam , clonazepam , na phenobarbital , primidone , carbamezepine , ethosuximide , diphenylhydantoin , na valproate , gabob ) show an activity which is does-dependent and within a range satisfactorily related to human dosages . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
157,
170
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
173,
182
]
} |
the antagonism between strychnine and atropine may be explained taking into account the presynaptic action of atropine and the antagonism between strychnine and pentobarbital is in agreement with a gabaergic action of the barbiturates . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
161,
174
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
222,
234
]
} |
calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
28,
37
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
42,
52
]
} |
in isolated and enriched guinea pig parietal cells the inhibitory effects of the calcium channel antagonists verapamil and gallopamil on 14c-aminopyrine uptake ( = h+ secretion ) have been analyzed . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
109,
118
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
123,
133
]
} |
both verapamil and gallopamil inhibit acid secretion in a concentration-dependent manner with an ic50 of 12.1 and 10.9 mumol/l respectively . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
5,
14
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
19,
29
]
} |
it is concluded that the calcium channel antagonists verapamil and gallopamil inhibit acid secretion in vitro by interfering with the parietal cell proton pump , the k+/h+-atpase . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
53,
62
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
67,
77
]
} |
the present study , using displacement by epinephrine , norepinephrine , isoproterenol and clonidine validated the use of these radioligands as appropriate for specific receptor binding in pancreatic islet cells . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} |
many nuclear proteins are phosphorylated : they range from enzymes to several structural proteins such as histones , non-histone chromosomal proteins and the nuclear lamins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
5,
21
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
106,
114
]
} |
many nuclear proteins are phosphorylated : they range from enzymes to several structural proteins such as histones , non-histone chromosomal proteins and the nuclear lamins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
5,
21
]
} | {
"id": "C0008600",
"name": "non-histone chromosomal proteins",
"pos": [
117,
149
]
} |
work on the phosphorylation of proteins as a dynamic process involved in the regulation of biological processes started in the 1950s with the finding that phosphorylase a and phosphorylase b are phospho and dephospho forms of the same enzyme . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
155,
168
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
175,
190
]
} |
another common technique is prolonged monitoring of the patient 's electroencephalogram ( eeg ) by radiotelemetry , during which time the patient is closely observed by trained personnel for suspected seizures.to compare the quality of information obtained from intensive monitoring with that from careful routine electroencephalography , the authors reviewed the medical records of 100 consecutive patients who had received both kinds of study after being referred for treatment in the special epilepsy treatment unit of the university of minnesota 's comprehensive epilepsy program ( cep ) . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
201,
209
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
567,
575
]
} |
the intensity of the red fluorescence ( from single-stranded dna ) divided by the green fluorescence ( from double-stranded dna ) was used as a measured of dna strand breaks . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
45,
64
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
108,
127
]
} |
the relative sensitivities of a human diploid fibroblast strain ( ag1522 ) and an established line of contact-inhibited mouse embryo fibroblasts ( 10t1/2 ) were compared after incorporation of [ 3h ] thymidine or [ 125i ] iododeoxyuridine into the cellular dna and growth at 37 degrees c . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
248,
256
]
} |
whereas these cells show similar sensitivities to acute x irradiation , the d0 for clonal survival of the mouse fibroblasts was 5- to 10-fold higher than the d0 for the human fibroblasts for both 3h and 125i . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
175,
186
]
} |
no distinctions were observed in the character and manifestation of disturbances of the lymphocyte migration after the injection of 35s-methionine and gamma-emitter , 75se-selenomethionine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
136,
146
]
} | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
172,
188
]
} |
the ratio of the tritium content per 1 m hydrogen of dna to tritium content per 1 m hydrogen of tissue water increased up to 0.5-0.7 during the uptake of tritium oxide , and up to 4-7 after the administration of the isotope had ceased . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
17,
24
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
84,
92
]
} |
ct-derived cross sections were correlated with age , height , weight , and body-surface area , and they were compared with findings of published clinical and post-mortem studies . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
62,
68
]
} | {
"id": "C0037088",
"name": "findings",
"pos": [
123,
131
]
} |
monoclonal antibodies have been applied as primary antibodies for the cellular and subcellular localisation of neuroactive substances . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} |
these data suggest that chronic haloperidol treatment and subsequent withdrawal results in the development of behavioural dopamine supersensitivity as well as biochemical alterations in dopaminergic and gabaergic system . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
122,
130
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
186,
198
]
} |
the effect of combined administration of l-dopa with apomorphine or with bromocriptine on rat striatal concentrations of dopamine ( da ) , dihydroxyphenylacetic ( dopac ) and dopa was investigated . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
41,
47
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
175,
179
]
} |
the dopa-induced elevations in striatal concentrations of da , dopac and dopa were similar among animals injected with l-dopa alone or in combination with apomorphine or bromocriptine . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
4,
8
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
119,
125
]
} |
prostaglandin ( pge , 6-keto pgf1 alpha ) output by cells dispersed from human amnion and decidua in the presence of increasing levels ( 0-5000 ng/ml ) of estradiol-17 beta ( e2 ) or 2-hydroxyestradiol-17 beta ( 2-oh e2 ) was studied in relation to parturition . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
0,
13
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
16,
19
]
} |
biotransformation and pharmacokinetic studies should be undertaken to obtain better understanding of the chemical 's metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
117,
127
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
132,
141
]
} |
the authors study fast eeg rhythms in amino acidopathies of the newborn and in progressive encephalopathy of the central nervous system in children , when an inborn error of metabolism has either been found or is suspected . | NA | {
"id": "C0002514",
"name": "amino acidopathies",
"pos": [
38,
56
]
} | {
"id": "C0025521",
"name": "inborn error of metabolism",
"pos": [
158,
184
]
} |
in the first group : amino acidopathies ( including phenylketonuria ) , fast rhythms on the eeg of the neonates are of low amplitude , spindle-like bursts of 7-13 hz and usually located in rolandic areas . | NA | {
"id": "C0002514",
"name": "amino acidopathies",
"pos": [
21,
39
]
} | {
"id": "C0031485",
"name": "phenylketonuria",
"pos": [
52,
67
]
} |
[ hyperinsulinism and insulin resistance diagnosed by oral and intravenous glucose loading and by the tolbutamide test in polycystic ovary syndrome ] . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
2,
17
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
22,
40
]
} |
confluent cultures of rat glomerular epithelial and mesangial cells were studied by immunofluorescent microscopy , using affinity-purified antibodies directed against collagen of type i-v or an antiserum directed against a basement membrane ( bm ) proteoglycan . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
139,
149
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
194,
203
]
} |
plasma from fasted ( as well as fed ) diabetics contained supranormal concentrations of several amino acids , including the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
96,
107
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
124,
150
]
} |
parallelly , lipid ( triglyceride and cholesterol ) and lipoprotein ( high-density/hdl/ , low-density/ldl/ , and very-low-density/vldl/ ) content in ascites and pleural effusions , were determined . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
56,
67
]
} |
there were similar changes in the cholesterol content of these lipoprotein fractions , i.e. , an increase of vldl- and a decrease of hdl- and ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
34,
45
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
142,
157
]
} |
although a yersinia infection has not been formally established as the cause , there is some indirect evidence pointing to the reality of systemic yersinia pseudotuberculosis infection . | NA | {
"id": "C0043407",
"name": "yersinia infection",
"pos": [
11,
29
]
} | {
"id": "C0043410",
"name": "yersinia pseudotuberculosis infection",
"pos": [
147,
184
]
} |
sjogren 's syndrome in systemic lupus erythematosus and rheumatoid arthritis : immune effector cells in salivary glands . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
0,
19
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
56,
76
]
} |
in secondary ( 2 degrees ) ss in cases of systemic lupus erythematosus ( sle ) and rheumatoid arthritis , respectively , 55 % +/- 4 % ( range 41-69 ) and 43 % +/- 7 % ( range 15-80 ) of all inflammatory cells in the periductal lymphocyte-rich infiltrates were t-pattern lymphocytes . | NA | {
"id": "C1527336",
"name": "ss",
"pos": [
27,
29
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
83,
103
]
} |
to determine the clinical significance of anti-centromere ( aca ) and anti scl-70 antibodies in an english population with connective tissue diseases , we examined the sera of 150 patients , including 40 with systemic sclerosis ( ss ) , who were prospectively studied on the same clinical protocol in our connective tissue disease clinic . | NA | {
"id": "C0036421",
"name": "systemic sclerosis",
"pos": [
209,
227
]
} | {
"id": "C0009782",
"name": "connective tissue",
"pos": [
305,
322
]
} |
anti scl-70 was detected in 20 % of the patients with ss and only two of those with other connective tissue diseases . | NA | {
"id": "C0036421",
"name": "ss",
"pos": [
54,
56
]
} | {
"id": "C0009782",
"name": "of",
"pos": [
70,
72
]
} |
however , the cholesterol ratio ( hdl cholesterol x 100/ldl + vldl cholesterol ) was not influenced by posture and should be evaluated instead of cholesterol fractions if the conditions for blood sampling were not controlled . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
34,
49
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
146,
157
]
} |
stone materials differ in weight distribution , and reports of composition in different weight ranges may facilitate comparison and compensate for bias in selection of stones for analysis . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
26,
32
]
} | {
"id": "C0005911",
"name": "different weight",
"pos": [
78,
94
]
} |
there were four perinatal deaths , of which two were stillbirths , further 3 infants died later as a result of abuse or neglect . | NA | {
"id": "C0701826",
"name": "perinatal deaths",
"pos": [
16,
32
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
85,
89
]
} |
as laboratory parameters , lipids , lipoproteins ( vldl , idl , ldl , hdl2 and hdl3 by rate zonal centrifugation ) and the percentage composition of the major apolipoproteins in vldl , hdl2 and hdl3 , as well as lipoprotein lipase ( lpl ) , hepatic lipase ( htgl ) and lecithin-cholesterol-acyl-transferase ( lcat ) were measured . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
27,
33
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
162,
174
]
} |
much remains to be understood of the mechanisms of ebv infections , which in some geographic areas lead to inapparent infections and in others to burkitt lymphoma or nasopharyngeal carcinoma , while in temperate regions the clinical manifestations are those of infectious mononucleosis . | NA | {
"id": "C0149678",
"name": "ebv infections",
"pos": [
51,
65
]
} | {
"id": "C0006413",
"name": "burkitt lymphoma",
"pos": [
146,
162
]
} |
binding and inactivation of isotopically labeled porcine pancreatic elastase and human neutrophil elastase by alpha 1-protease inhibitor were measured in fluid obtained by bronchoalveolar lavage of volunteers . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
57,
76
]
} | {
"id": "C0064833",
"name": "neutrophil elastase",
"pos": [
87,
106
]
} |
moxalactam has little , if any , interactions with penicillinases , as is also the case of cefoxitin , cefuroxime and cefotaxime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
103,
113
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} |
moxalactam elimination kinetics are linear , independent from the dose and route of administration , with a distribution half-life ( t 1/2 alpha ) between 0.20 and 0.60 hours and an elimination half-life ( t 1/2 beta ) between 2 and 2.5 hours ( range : 1.9 and 3.1 hours ) . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
23,
31
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
194,
203
]
} |
the distribution and incidence of the spinal and extraspinal hyperostosis in this series corresponds closely to the findings in diffuse idiopathic skeletal hyperostosis ( dish ) . | NA | {
"id": "C0020492",
"name": "hyperostosis",
"pos": [
61,
73
]
} | {
"id": "C0020498",
"name": "diffuse idiopathic skeletal hyperostosis",
"pos": [
128,
168
]
} |
in western countries two common and successful measures employed to combat nutritional deficiencies and deficiency diseases are : ( i ) enrichment of refined cereal products with nutrients lost during milling ; | NA | {
"id": "C0162429",
"name": "nutritional deficiencies",
"pos": [
75,
99
]
} | {
"id": "C0011156",
"name": "deficiency diseases",
"pos": [
104,
123
]
} |
the prolonged administration of epsilon-aminocaproic acid ( eaca ) resulted in the development of severe proximal myopathy associated with high plasma creatine kinase values , rhabdomyolysis , myoglobinuria , and mild hyperbilirubinaemia . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
176,
190
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
193,
206
]
} |
one died on day 3 of low-output syndrome and the other had rapidly progressive nephrosclerosis and died of that disease one year later . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
32,
40
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
112,
119
]
} |
we attempted to examine procoagulant activity ( pca ) , x activator activity ( xaa ) and plasminogen activator activity ( plgaa ) of various leukemic cell lysates : 17 acute myelocytic leukemias ( aml ) , 4 acute promyelocytic leukemias ( apl ) , 9 acute myelomonocytic leukemias ( ammol ) , 7 chronic myelocytic leukemias ( cml ) , 4 cml with blastic crisis , 7 t cell acute lymphocytic leukemias ( all ) , 8 adult t cell leukemias ( atl ) , 8 null cell all , 6 b cell lymphocytic leukemias . | NA | {
"id": "C0023467",
"name": "acute myelocytic leukemias",
"pos": [
168,
194
]
} | {
"id": "C0023487",
"name": "acute promyelocytic leukemias",
"pos": [
207,
236
]
} |
among those 70 cases , 4 apl , 4 ammol and 5 aml were associated with overt disseminated intravascular coagulation ( dic ) and 5 t cell all , 7 atl and 2 null cell all were associated with hypofibrinogenemia not adapted for dic . | NA | {
"id": "C0023487",
"name": "apl",
"pos": [
25,
28
]
} | {
"id": "C0023467",
"name": "aml",
"pos": [
45,
48
]
} |
apl and aml , especially those associated with overt dic , had high pca , and lymphocytic leukemia generally had low pca in comparison with normal controls . | NA | {
"id": "C0023487",
"name": "apl",
"pos": [
0,
3
]
} | {
"id": "C0023467",
"name": "aml",
"pos": [
8,
11
]
} |
a rapid and highly sensitive solid phase assay was compared with the fibrin plate method for the measurement of urokinase , streptokinase and the plasminogen activators in human euglobulin fractions . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
124,
137
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
146,
157
]
} |
isolation and anticoagulant properties of a new sulfated xylan : comparison with heparin and a sodium pentosan polysulfate ( sp-54 ) . | NA | {
"id": "C0030888",
"name": "sulfated xylan",
"pos": [
48,
62
]
} | {
"id": "C0524684",
"name": "sodium pentosan polysulfate",
"pos": [
95,
122
]
} |
plasma is incubated with cellulose-antibody for 2 hours , fluorescent-labelled antiserum is added and the samples are allowed to react for an additional 2 hours . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
35,
43
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
79,
88
]
} |
the cellulose-antibody reagent and the fluorescent-labelled antiserum were both stable over a period of 1 year , demonstrating a major advantage of fluoroimmunoassay over radioimmunoassay . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
60,
69
]
} |
in adrenaline and noradrenaline ( 10 ( -8 ) -10 ( -5 ) g/ml ) , the ijp could be evoked in spite of a hyperpolarization of the cell membrane . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
3,
13
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} |
since a single po dose of methaqualone failed to produce any alteration in the rate of metabolism of acetylsalicylic acid , procaine , p-nitrophenylacetate , acetanilid , and butyrylcholine within 20 hr , it may be interpreted that the stimulation of acetylsalicylic acid and acetanilid metabolism is possibly due to selective enhanced de novo synthesis of the enzymes/isozymes necessary for the hydrolysis of the two drugs . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
361,
368
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
369,
377
]
} |
the absorption , distribution , excretion , and metabolism of a single oral dose of o-ethyl o-4-nitrophenyl phenylphosphonothioate in hens . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
48,
58
]
} |
acute ethanol intake diminished liver gsh content by 30 % and enhanced that of gssg by 73 % , thus eliciting a net decrease of 20 % in total gsh equivalents ( gsh + 2gssg ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
79,
83
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
159,
162
]
} |
the combined administration of iron and ethanol further influenced the decrease in hepatic gsh and the increase in gssg levels elicited by the separate treatments , but no alterations in the biliary content and release of total gsh were observed in this situation . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
115,
119
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
228,
231
]
} |
fischer 344 rats were fed semi-purified rations containing 20 % w/w corn that was either free of aflatoxin or naturally contaminated with 880 micrograms/kg total aflatoxin and was either treated with ammonia gas or was not treated . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
200,
207
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
208,
211
]
} |
smaller amounts of some of the esters caused a characteristic chronic lung lesion , with proliferation of alveolar tissue , resembling that produced by the pyrrolizidine alkaloids fulvine and monocrotaline . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloids",
"pos": [
156,
179
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
192,
205
]
} |
the response criteria developed in experimental radiotherapy of mouse tumours are applicable to human tumour response , too . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
35,
47
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
102,
108
]
} |
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