instruction stringlengths 142 1.78k | input stringlengths 321 1.59k | response stringclasses 11 values |
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<Instruct>: Given the context 'Furthermore, a subset of TGF-β-related growth and differentiation factors (GDFs), e.g., GDF8, GDF9, GDF11 and GDF15 could induce these events [17,18,32,33].', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: opn1lw (aka long-wave-sensitive opsin 1)
B: xc chemokine receptor 1 (aka chemokine xc receptor 1)
C: cmkor1 (aka c-x-c chemokine receptor type 7)
D: mc1qb (aka complement c1q subcomponent subunit b (mouse))
E: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
F: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
G: nmbr (aka neuromedin-b receptor) (aka neuromedin-b receptor)
H: rhodopsin (opn2 (aka rhodopsin))
I: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
J: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
K: None of the above. | K |
<Instruct>: Given the context 'Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
', select the correct biomedical concept corresponding to 'gdfs 8'. Answer using one of the provided options. | <Options>: A: smel-cbbl (aka ribulose bisphosphate carboxylase large chain (sinorhizobium meliloti 1021))
B: pb-ckr (aka c-x-c chemokine receptor type 4)
C: olfactory receptor 2m6 (aka olfactory receptor 2m3)
D: pachytene arrest protein sae3 (yeast) (sporulation in the absence of spo11 protein 3 (yeast)) (aka pachytene arrest protein sae3 (yeast))
E: sptssb (aka small subunit of serine palmitoyltransferase b)
F: sensory axon guidance 3 (caenorhabditis elegans) (aka protein sax-3 (caenorhabditis elegans))
G: meckelin (meckel syndrome type 3 protein homolog) (aka meckelin)
H: or2m2 (aka olfactory receptor 2m2)
I: smel-prkb (aka phosphoribulokinase (sinorhizobium meliloti 1021))
J: serine palmitoyltransferase complex 4 (human)
K: None of the above. | K |
<Instruct>: Given the context 'Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
', select the correct biomedical concept corresponding to 'gdfs ... 9'. Answer using one of the provided options. | <Options>: A: pachytene arrest protein sae3 (yeast) (sporulation in the absence of spo11 protein 3 (yeast)) (aka pachytene arrest protein sae3 (yeast))
B: transmembrane protein 67 (aka meckelin)
C: or2m2 (aka olfactory receptor 2m2)
D: tmem55a (aka transmembrane protein 55a)
E: olfactory receptor 2m6 (aka olfactory receptor 2m3)
F: bfit (aka acyl-coenzyme a thioesterase 11) (aka acyl-coenzyme a thioesterase 11)
G: cte-ib (aka acyl-coenzyme a thioesterase 1)
H: tmem59l (aka transmembrane protein 59-like)
I: dynamin isoform f (fruit fly) (aka dynamin isoform 1 (fruit fly))
J: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (type i phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (aka type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase)
K: None of the above. | K |
<Instruct>: Given the context 'Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
', select the correct biomedical concept corresponding to 'gdfs ... 11'. Answer using one of the provided options. | <Options>: A: uniprotkb:p12270, 2-2363 (aka nucleoprotein tpr, initiator methionine removed form (human))
B: acyl-coenzyme a thioesterase 11 (bfit (aka acyl-coenzyme a thioesterase 11))
C: brain-specific membrane-anchored protein (aka transmembrane protein 59-like)
D: pachytene arrest protein sae3 (yeast) (sporulation in the absence of spo11 protein 3 (yeast)) (aka pachytene arrest protein sae3 (yeast))
E: cytochrome p450 315a1, mitochondrial (fruit fly) (protein shadow (fruit fly)) (aka cytochrome p450 315a1, mitochondrial (fruit fly))
F: nf-e2-inducible protein 2 (aka vacuole membrane protein 1)
G: transmembrane protein 67 (aka meckelin)
H: tmem38b (aka trimeric intracellular cation channel type b)
I: fly-mthl5 (aka g-protein coupled receptor mth-like 5 (fruit fly))
J: clspa (aka complement c1r subcomponent-like protein)
K: None of the above. | K |
<Instruct>: Given the context 'Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
', select the correct biomedical concept corresponding to 'gdfs ... 15'. Answer using one of the provided options. | <Options>: A: complement component 1 subcomponent s (aka complement c1s subcomponent)
B: transmembrane protein 55b (aka type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase)
C: or2m2 (aka olfactory receptor 2m2)
D: nf-e2-inducible protein 2 (aka vacuole membrane protein 1)
E: clspa (aka complement c1r subcomponent-like protein)
F: bsmap (aka transmembrane protein 59-like)
G: thea (aka acyl-coenzyme a thioesterase 11) (aka acyl-coenzyme a thioesterase 11)
H: tmem43 (aka transmembrane protein 43)
I: cte-i (aka acyl-coenzyme a thioesterase 1)
J: nucleoporin ndc1 (transmembrane protein 48) (aka nucleoporin ndc1)
K: None of the above. | K |
<Instruct>: Given the context 'Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
', select the correct biomedical concept corresponding to 'tgf-βs'. Answer using one of the provided options. | <Options>: A: opn1lw (aka long-wave-sensitive opsin 1)
B: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
C: nmbr (aka neuromedin-b receptor) (aka neuromedin-b receptor)
D: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
E: gpr159 (aka c-x-c chemokine receptor type 7)
F: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
G: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
H: chemokine receptor xcr1 (aka chemokine xc receptor 1)
I: None of the above. | I |
<Instruct>: Given the context 'Although some NC-derived cells appeared to be differentiating to smooth muscle cells in the OFT (Fig. 6), we could never detect the AP septum forming in Alk5/Wnt1-Cre mutants between E10.5 and E11.5.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: smad4/var:2 (aka smad4 sequence variant 2)
B: dwarfin-c (aka smad5)
C: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
D: btn1a1 (aka butyrophilin subfamily 1 member a1)
E: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
F: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
G: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
H: ca-ii (aka carbonic anhydrase 2)
I: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
J: protein tob5 (aka protein btg3)
K: None of the above. | K |
<Instruct>: Given the context 'Although some NC-derived cells appeared to be differentiating to smooth muscle cells in the OFT (Fig. 6), we could never detect the AP septum forming in Alk5/Wnt1-Cre mutants between E10.5 and E11.5.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
B: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
C: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
D: shh-n (aka sonic hedgehog protein n-product)
E: eif-3 p48 (aka eukaryotic translation initiation factor 3 subunit e)
F: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
G: mumps (aka uridine 5'-monophosphate synthase (mouse))
H: eukaryotic translation initiation factor 3 subunit f (eukaryotic translation initiation factor 3 subunit 5) (aka eukaryotic translation initiation factor 3 subunit f)
I: spbc1604.08c (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
J: uncharacterized hth-type transcriptional regulator ycjz (ycjz (aka uncharacterized hth-type transcriptional regulator ycjz))
K: None of the above. | K |
<Instruct>: Given the context 'Several in vitro studies have suggested an indispensable role for TGF-β-signaling in differentiation of NCCs into smooth muscle cells.', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: cdk-activating kinase assembly factor mat1 homolog (schizosaccharomyces pombe 972h-) (aka rna polymerase ii transcription factor b subunit 3 (schizosaccharomyces pombe 972h-))
B: opn1lw (aka long-wave-sensitive opsin 1)
C: mc1qb (aka complement c1q subcomponent subunit b (mouse))
D: rhodopsin (opn2 (aka rhodopsin))
E: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
F: tgf-beta 1 sequence variant 2 (tgfb1/var:2) (aka tgf-beta 1 sequence variant 2)
G: lymphotactin receptor (aka chemokine xc receptor 1)
H: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
I: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
J: gpr159 (aka c-x-c chemokine receptor type 7)
K: None of the above. | K |
<Instruct>: Given the context 'Moreover, a recent in vivo study suggested that mice lacking Tgfbr2 in CNCCs display defective NCC differentiation into αSMA-positive cells in the AP septum [9], although this result was later disputed by another study', select the correct biomedical concept corresponding to 'αsma'. Answer using one of the provided options. | <Options>: A: prostate differentiation factor (aka growth/differentiation factor 15)
B: abc transporter g family member 14 (dictyostelium discoideum) (abc transporter abcg.14 (dictyostelium discoideum)) (aka abc transporter g family member 14 (dictyostelium discoideum))
C: arf-gap with sh3 domain, ank repeat and ph domain-containing protein 1 isoform m1 phosphorylated 1 (mouse) (asap1 phosphorylated 1) (aka arf-gap with sh3 domain, ank repeat and ph domain-containing protein 1 isoform m1 phosphorylated 1 (mouse))
D: ykl015w (aka proline utilization trans-activator (yeast))
E: claudin-15 (human) (hcldn15) (aka claudin-15 (human))
F: neurotrypsin (human) (hprss12) (aka neurotrypsin (human))
G: hwnt2/sigpep- (aka protein wnt-2, signal peptide removed form (human))
H: hsoga1/iso:h4 (aka protein soga1 isoform h4 (human))
I: mkdm1a/iso:m4 (aka lysine-specific histone demethylase 1a isoform m4 (mouse))
J: gdap1-l1 (aka ganglioside-induced differentiation-associated protein 1-like 1)
K: None of the above. | K |
<Instruct>: Given the context 'Our immunohistochemical staining of αSMA in the OFT unequivocally demonstrated that signaling via ALK5 is not required for smooth muscle differentiation in vivo.', select the correct biomedical concept corresponding to 'αsma'. Answer using one of the provided options. | <Options>: A: cardiac mybp-c (rat) (aka myosin-binding protein c, cardiac-type (rat))
B: uc28 (aka prostate and breast cancer overexpressed gene 1 protein) (aka prostate and breast cancer overexpressed gene 1 protein)
C: mir16 (aka glycerophosphodiester phosphodiesterase 1)
D: hsoga1/iso:h4 (aka protein soga1 isoform h4 (human))
E: arf-gap with sh3 domain, ank repeat and ph domain-containing protein 1 isoform m1 phosphorylated 1 (mouse) (asap1 phosphorylated 1) (aka arf-gap with sh3 domain, ank repeat and ph domain-containing protein 1 isoform m1 phosphorylated 1 (mouse))
F: msmo/iso:1 (aka smoothened homolog isoform 1 (mouse))
G: proto-oncogene wnt-3, signal peptide removed form (human) (uniprotkb:p56703, 22-355) (aka proto-oncogene wnt-3, signal peptide removed form (human))
H: hwnt2/sigpep- (aka protein wnt-2, signal peptide removed form (human))
I: ganglioside-induced differentiation-associated protein 2 (gdap2) (aka ganglioside-induced differentiation-associated protein 2)
J: abc transporter g family member 14 (dictyostelium discoideum) (abc transporter abcg.14 (dictyostelium discoideum)) (aka abc transporter g family member 14 (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'Our immunohistochemical staining of αSMA in the OFT unequivocally demonstrated that signaling via ALK5 is not required for smooth muscle differentiation in vivo.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: protein pc3b (aka protein btg4)
B: ca-ii (aka carbonic anhydrase 2)
C: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
D: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
E: btn1a1 (aka butyrophilin subfamily 1 member a1)
F: hmad-3 (aka smad3)
G: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
H: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
I: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
J: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
K: None of the above. | K |
<Instruct>: Given the context 'Our present results suggest that although many of the observed phenotypes seen in Alk5/Wnt1-Cre mutants superficially resemble those seen in VCF/DGS, a detailed examination shows that the NC-specific abrogation of Alk5 does not lead to VCF/DGS-like phenotypes.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
B: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
C: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
D: protein tob5 (aka protein btg3)
E: smad4/var:2 (aka smad4 sequence variant 2)
F: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
G: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
H: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
I: protein pc3b (aka protein btg4)
J: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
K: None of the above. | K |
<Instruct>: Given the context 'Our present results suggest that although many of the observed phenotypes seen in Alk5/Wnt1-Cre mutants superficially resemble those seen in VCF/DGS, a detailed examination shows that the NC-specific abrogation of Alk5 does not lead to VCF/DGS-like phenotypes.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
B: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
C: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
D: eif3e (aka eukaryotic translation initiation factor 3 subunit e)
E: ycjz (aka uncharacterized hth-type transcriptional regulator ycjz) (aka uncharacterized hth-type transcriptional regulator ycjz)
F: eukaryotic translation initiation factor 3 subunit f (eukaryotic translation initiation factor 3 subunit 5) (aka eukaryotic translation initiation factor 3 subunit f)
G: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
H: mumps (aka uridine 5'-monophosphate synthase (mouse))
I: spbc1604.08c (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
J: shh-n (aka sonic hedgehog protein n-product)
K: None of the above. | K |
<Instruct>: Given the context 'Our present results suggest that although many of the observed phenotypes seen in Alk5/Wnt1-Cre mutants superficially resemble those seen in VCF/DGS, a detailed examination shows that the NC-specific abrogation of Alk5 does not lead to VCF/DGS-like phenotypes.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
B: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
C: ca-ii (aka carbonic anhydrase 2)
D: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
E: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
F: dwarfin-c (aka smad5)
G: protein pc3b (aka protein btg4)
H: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
I: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
J: isoform a (aka tgf-beta 2 isoform a)
K: None of the above. | K |
<Instruct>: Given the context 'Firstly, while the pharyngeal organ migration fails in Alk5/Wnt1-Cre mutants, perhaps as a result of increased mesenchymal cell death in the pharyngeal region, both the thymus, thyroid and parathyroid seem to develop relatively normally on the histological level in these mutants.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
B: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
C: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
D: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
E: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
F: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
G: btn1a1 (aka butyrophilin subfamily 1 member a1)
H: hmad-3 (aka smad3)
I: c-c ckr-2 (aka c-c chemokine receptor type 2)
J: protein tob5 (aka protein btg3)
K: None of the above. | K |
<Instruct>: Given the context 'Firstly, while the pharyngeal organ migration fails in Alk5/Wnt1-Cre mutants, perhaps as a result of increased mesenchymal cell death in the pharyngeal region, both the thymus, thyroid and parathyroid seem to develop relatively normally on the histological level in these mutants.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
B: eukaryotic translation initiation factor 3 subunit f (eukaryotic translation initiation factor 3 subunit 5) (aka eukaryotic translation initiation factor 3 subunit f)
C: eif3e (aka eukaryotic translation initiation factor 3 subunit e)
D: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
E: karyopherin subunit alpha-2 (schizosaccharomyces pombe 972h-) (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
F: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
G: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
H: ycjz (aka uncharacterized hth-type transcriptional regulator ycjz) (aka uncharacterized hth-type transcriptional regulator ycjz)
I: sonic hedgehog protein n-product (shh/clv:nter) (aka sonic hedgehog protein n-product)
J: mumps (aka uridine 5'-monophosphate synthase (mouse))
K: None of the above. | K |
<Instruct>: Given the context 'Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
B: hmad-3 (aka smad3)
C: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
D: dwarfin-c (aka smad5)
E: protein tob5 (aka protein btg3)
F: protein pc3b (aka protein btg4)
G: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
H: smad4/var:2 (aka smad4 sequence variant 2)
I: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
J: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region', select the correct biomedical concept corresponding to 'tbx1'. Answer using one of the provided options. | <Options>: A: anti-adapter protein iram (escherichia coli k-12) (ec-iram) (aka anti-adapter protein iram (escherichia coli k-12))
B: hth-type transcriptional repressor ycge (escherichia coli k-12) (ec-ycge) (aka hth-type transcriptional repressor ycge (escherichia coli k-12))
C: uncharacterized protein yjhg (escherichia coli k-12) (ec-yjhg) (aka uncharacterized protein yjhg (escherichia coli k-12))
D: yqja (aka inner membrane protein yqja) (aka inner membrane protein yqja)
E: retinol-binding protein 3, signal peptide removed form (rbp3/sigpep-) (aka retinol-binding protein 3, signal peptide removed form)
F: mdpysl4/iso:m2 (aka dihydropyrimidinase-related protein 4 isoform m2 (mouse))
G: mtm7sf2/iso:1 (aka delta(14)-sterol reductase isoform 1 (mouse))
H: rbp3/full (aka retinol-binding protein 3, full-length form)
I: tmem232 (aka transmembrane protein 232)
J: uncharacterized lyase yjhh (escherichia coli k-12) (ec-yjhh) (aka uncharacterized lyase yjhh (escherichia coli k-12))
K: None of the above. | K |
<Instruct>: Given the context 'Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region', select the correct biomedical concept corresponding to 'crkl'. Answer using one of the provided options. | <Options>: A: calcium-binding protein 4 isoform h2 (human) (hcabp4/iso:h2) (aka calcium-binding protein 4 isoform h2 (human))
B: npp-5 (rat) (aka ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (rat))
C: ptx homeobox protein
D: noggin (nog (aka noggin))
E: ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 (rat) (renpp5/iso:1) (aka ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 (rat))
F: pro_0000035830 (aka tyrosine--trna ligase, mitochondrial, transit peptide removed form (human))
G: at-cslb4 (aka cellulose synthase-like protein b4 (arabidopsis thaliana))
H: bhlh clade b (aka myc protein)
I: carp-2 (aka e3 ubiquitin-protein ligase rififylin)
J: kinase-related transforming protein (aka mitogen-activated protein kinase)
K: None of the above. | K |
<Instruct>: Given the context 'While the detected OFT phenotype in Alk5/Wnt1-Cre mutants shared many similarities with that seen in the chick NC ablation models, e.g., PTA and the hypoplastic aortic sac, our current results suggest that the secondary heart field is not severely affected in Alk5 mutants (data not shown).', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: protein tob5 (aka protein btg3)
B: isoform a (aka tgf-beta 2 isoform a)
C: protein pc3b (aka protein btg4)
D: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
E: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
F: hmad-3 (aka smad3)
G: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
H: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
I: c-c ckr-2 (aka c-c chemokine receptor type 2)
J: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'While the detected OFT phenotype in Alk5/Wnt1-Cre mutants shared many similarities with that seen in the chick NC ablation models, e.g., PTA and the hypoplastic aortic sac, our current results suggest that the secondary heart field is not severely affected in Alk5 mutants (data not shown).', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
B: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
C: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
D: eif3s6 (aka eukaryotic translation initiation factor 3 subunit e)
E: spbc1604.08c (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
F: eukaryotic translation initiation factor 3 subunit 5 (aka eukaryotic translation initiation factor 3 subunit f)
G: uncharacterized hth-type transcriptional regulator ycjz (ycjz (aka uncharacterized hth-type transcriptional regulator ycjz))
H: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
I: sonic hedgehog protein n-product (shh/clv:nter) (aka sonic hedgehog protein n-product)
J: mumps (aka uridine 5'-monophosphate synthase (mouse))
K: None of the above. | K |
<Instruct>: Given the context 'While the detected OFT phenotype in Alk5/Wnt1-Cre mutants shared many similarities with that seen in the chick NC ablation models, e.g., PTA and the hypoplastic aortic sac, our current results suggest that the secondary heart field is not severely affected in Alk5 mutants (data not shown).', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: protein pc3b (aka protein btg4)
B: ca-ii (aka carbonic anhydrase 2)
C: btn1a1 (aka butyrophilin subfamily 1 member a1)
D: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
E: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
F: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
G: c-c ckr-2 (aka c-c chemokine receptor type 2)
H: hmad-3 (aka smad3)
I: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
J: smad4/var:2 (aka smad4 sequence variant 2)
K: None of the above. | K |
<Instruct>: Given the context 'Since we could not detect appropriate rotation of the OFT in neural crest-specific mutants of Alk5 or Alk2, it appears that cells derived from the NC, as well as those from the SHF, are mutually required for proper OFT rotation in mice.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: ca-ii (aka carbonic anhydrase 2)
B: protein tob5 (aka protein btg3)
C: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
D: dwarfin-c (aka smad5)
E: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
F: hmad-3 (aka smad3)
G: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
H: isoform a (aka tgf-beta 2 isoform a)
I: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
J: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Since we could not detect appropriate rotation of the OFT in neural crest-specific mutants of Alk5 or Alk2, it appears that cells derived from the NC, as well as those from the SHF, are mutually required for proper OFT rotation in mice.', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
B: btn1a1 (aka butyrophilin subfamily 1 member a1)
C: ca-ii (aka carbonic anhydrase 2)
D: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
E: protein pc3b (aka protein btg4)
F: dwarfin-c (aka smad5)
G: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
H: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
I: protein tob5 (aka protein btg3)
J: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
K: None of the above. | K |
<Instruct>: Given the context 'However, it appears that these two TGF-β/BMP type I receptors contribute to OFT rotation through different mechanisms.', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: opn1lw (aka long-wave-sensitive opsin 1)
B: mc1qb (aka complement c1q subcomponent subunit b (mouse))
C: rhodopsin (opn2 (aka rhodopsin))
D: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
E: gpr159 (aka c-x-c chemokine receptor type 7)
F: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
G: nmbr (aka neuromedin-b receptor) (aka neuromedin-b receptor)
H: chemokine receptor xcr1 (aka chemokine xc receptor 1)
I: cdk-activating kinase assembly factor mat1 homolog (schizosaccharomyces pombe 972h-) (aka rna polymerase ii transcription factor b subunit 3 (schizosaccharomyces pombe 972h-))
J: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
K: None of the above. | K |
<Instruct>: Given the context 'However, it appears that these two TGF-β/BMP type I receptors contribute to OFT rotation through different mechanisms.', select the correct biomedical concept corresponding to 'bmp'. Answer using one of the provided options. | <Options>: A: acyl-coa thioesterase 11 (aka acyl-coenzyme a thioesterase 11)
B: c9orf87 (aka trimeric intracellular cation channel type b)
C: mad homolog 3 (aka smad3)
D: gst class-alpha member 3 (mouse) (aka glutathione s-transferase a3 (mouse))
E: p80 (mouse) (aka interleukin-1 receptor type 1 (mouse))
F: citrate hydro-lyase (aka aconitate hydratase, mitochondrial)
G: mc-2 (aka melanocortin receptor 5) (aka melanocortin receptor 5)
H: long chain acyl-coa hydrolase (aka acyl-coenzyme a thioesterase 1)
I: melanocortin receptor 4 (mc4r (aka melanocortin receptor 4))
J: chemokine receptor cxcr3 (aka c-x-c chemokine receptor type 3)
K: None of the above. | K |
<Instruct>: Given the context 'In Alk5 mutants there is very little, if any, detectable septal mesenchyme present, and thus it could be argued that in these mutants OFT rotation fails due to a lack of penetration of septal prongs into the cushion mesenchyme.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
B: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
C: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
D: protein tob5 (aka protein btg3)
E: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
F: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
G: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
H: ca-ii (aka carbonic anhydrase 2)
I: dwarfin-c (aka smad5)
J: btn1a1 (aka butyrophilin subfamily 1 member a1)
K: None of the above. | K |
<Instruct>: Given the context 'In contrast, in Alk2/Wnt1-Cre mutants a sizeable septal mesenchyme could be seen, still without any obvious looping of the aortic sac and truncal OFT, suggesting that the mere presence of the septal mesenchyme, without correct smooth muscle cell differentiation, is not sufficient for OFT rotation.
', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
B: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
C: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
D: protein pc3b (aka protein btg4)
E: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
F: smad4/var:2 (aka smad4 sequence variant 2)
G: btn1a1 (aka butyrophilin subfamily 1 member a1)
H: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
I: ca-ii (aka carbonic anhydrase 2)
J: hmad-3 (aka smad3)
K: None of the above. | K |
<Instruct>: Given the context 'In contrast, in Alk2/Wnt1-Cre mutants a sizeable septal mesenchyme could be seen, still without any obvious looping of the aortic sac and truncal OFT, suggesting that the mere presence of the septal mesenchyme, without correct smooth muscle cell differentiation, is not sufficient for OFT rotation.
', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
B: ycjz (aka uncharacterized hth-type transcriptional regulator ycjz) (aka uncharacterized hth-type transcriptional regulator ycjz)
C: mumps (aka uridine 5'-monophosphate synthase (mouse))
D: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
E: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
F: shh-n (aka sonic hedgehog protein n-product)
G: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
H: eukaryotic translation initiation factor 3 subunit 5 (aka eukaryotic translation initiation factor 3 subunit f)
I: eif3e (aka eukaryotic translation initiation factor 3 subunit e)
J: spbc1604.08c (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
K: None of the above. | K |
<Instruct>: Given the context 'Conclusion
In this study, we have deleted the TGF-β type I receptor (Alk5) gene specifically in the mouse neural crest (NC) cell lineage.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
B: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
C: btn1a1 (aka butyrophilin subfamily 1 member a1)
D: c-c ckr-2 (aka c-c chemokine receptor type 2)
E: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
F: dwarfin-c (aka smad5)
G: protein tob5 (aka protein btg3)
H: protein pc3b (aka protein btg4)
I: smad4/var:2 (aka smad4 sequence variant 2)
J: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
K: None of the above. | K |
<Instruct>: Given the context 'Conclusion
In this study, we have deleted the TGF-β type I receptor (Alk5) gene specifically in the mouse neural crest (NC) cell lineage.', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: rhodopsin (opn2 (aka rhodopsin))
B: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
C: mc1qb (aka complement c1q subcomponent subunit b (mouse))
D: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
E: lymphotactin receptor (aka chemokine xc receptor 1)
F: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
G: opn1lw (aka long-wave-sensitive opsin 1)
H: neuromedin-b-preferring bombesin receptor (aka neuromedin-b receptor)
I: cdk-activating kinase assembly factor mat1 homolog (schizosaccharomyces pombe 972h-) (aka rna polymerase ii transcription factor b subunit 3 (schizosaccharomyces pombe 972h-))
J: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
K: None of the above. | K |
<Instruct>: Given the context 'Our data suggest that ALK5 is required cell autonomously in the NC to mediate non-redundant signaling events that are essential for appropriate patterning of the pharyngeal organs and cardiac OFT.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
B: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
C: dwarfin-c (aka smad5)
D: ca-ii (aka carbonic anhydrase 2)
E: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
F: btn1a1 (aka butyrophilin subfamily 1 member a1)
G: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
H: smad4/var:2 (aka smad4 sequence variant 2)
I: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
J: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'The cardiac and pharyngeal defects observed in the NC-specific Alk5 mutants differ significantly from those seen in corresponding mutants lacking the TGF-β type II receptor, suggesting that signaling mediated by ALK5 is not limited to the classical TGF-β ligands during cardiac/pharyngeal development.
', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: btn1a1 (aka butyrophilin subfamily 1 member a1)
B: protein tob5 (aka protein btg3)
C: monocyte chemoattractant protein 1 receptor (aka c-c chemokine receptor type 2)
D: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
E: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
F: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
G: protein pc3b (aka protein btg4)
H: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
I: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
J: hmad-3 (aka smad3)
K: None of the above. | K |
<Instruct>: Given the context 'The cardiac and pharyngeal defects observed in the NC-specific Alk5 mutants differ significantly from those seen in corresponding mutants lacking the TGF-β type II receptor, suggesting that signaling mediated by ALK5 is not limited to the classical TGF-β ligands during cardiac/pharyngeal development.
', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
B: opn1lw (aka long-wave-sensitive opsin 1)
C: mc1qb (aka complement c1q subcomponent subunit b (mouse))
D: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
E: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
F: lymphotactin receptor (aka chemokine xc receptor 1)
G: nmbr (aka neuromedin-b receptor) (aka neuromedin-b receptor)
H: rhodopsin (opn2 (aka rhodopsin))
I: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
J: cdk-activating kinase assembly factor mat1 homolog (schizosaccharomyces pombe 972h-) (aka rna polymerase ii transcription factor b subunit 3 (schizosaccharomyces pombe 972h-))
K: None of the above. | K |
<Instruct>: Given the context 'The cardiac and pharyngeal defects observed in the NC-specific Alk5 mutants differ significantly from those seen in corresponding mutants lacking the TGF-β type II receptor, suggesting that signaling mediated by ALK5 is not limited to the classical TGF-β ligands during cardiac/pharyngeal development.
', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
B: btn1a1 (aka butyrophilin subfamily 1 member a1)
C: ca-ii (aka carbonic anhydrase 2)
D: protein pc3b (aka protein btg4)
E: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
F: hmad-3 (aka smad3)
G: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
H: c-c ckr-2 (aka c-c chemokine receptor type 2)
I: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
J: protein tob5 (aka protein btg3)
K: None of the above. | K |
<Instruct>: Given the context 'The cardiac and pharyngeal defects observed in the NC-specific Alk5 mutants differ significantly from those seen in corresponding mutants lacking the TGF-β type II receptor, suggesting that signaling mediated by ALK5 is not limited to the classical TGF-β ligands during cardiac/pharyngeal development.
', select the correct biomedical concept corresponding to 'tgf-β'. Answer using one of the provided options. | <Options>: A: ackr3 (aka c-x-c chemokine receptor type 7)
B: lymphotactin receptor (aka chemokine xc receptor 1)
C: rhodopsin (opn2 (aka rhodopsin))
D: syf2/initmet- (aka pre-mrna-splicing factor syf2, initiator methionine removed form)
E: tgfb1/var:2 (aka tgf-beta 1 sequence variant 2)
F: acvrl1/var:6 (aka serine/threonine-protein kinase receptor r3 sequence variant 6)
G: opn1lw (aka long-wave-sensitive opsin 1)
H: cdk-activating kinase assembly factor mat1 homolog (schizosaccharomyces pombe 972h-) (aka rna polymerase ii transcription factor b subunit 3 (schizosaccharomyces pombe 972h-))
I: symplekin, initiator methionine removed form (sympk/initmet-) (aka symplekin, initiator methionine removed form)
J: neuromedin-b-preferring bombesin receptor (aka neuromedin-b receptor)
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
B: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
C: btn1a1 (aka butyrophilin subfamily 1 member a1)
D: smad4/var:2 (aka smad4 sequence variant 2)
E: hmad-3 (aka smad3)
F: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
G: dwarfin-c (aka smad5)
H: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
I: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
J: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: btn1a1 (aka butyrophilin subfamily 1 member a1)
B: hmad-3 (aka smad3)
C: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
D: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
E: dwarfin-c (aka smad5)
F: protein tob5 (aka protein btg3)
G: protein pc3b (aka protein btg4)
H: isoform a (aka tgf-beta 2 isoform a)
I: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
J: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
B: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
C: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
D: btn1a1 (aka butyrophilin subfamily 1 member a1)
E: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
F: isoform a (aka tgf-beta 2 isoform a)
G: protein tob5 (aka protein btg3)
H: hmad-3 (aka smad3)
I: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
J: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: protein tob5 (aka protein btg3)
B: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
C: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
D: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
E: smad4/var:2 (aka smad4 sequence variant 2)
F: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
G: ca-ii (aka carbonic anhydrase 2)
H: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
I: c-c ckr-2 (aka c-c chemokine receptor type 2)
J: hmad-3 (aka smad3)
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: protein pc3b (aka protein btg4)
B: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
C: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
D: btn1a1 (aka butyrophilin subfamily 1 member a1)
E: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
F: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
G: smad4/var:2 (aka smad4 sequence variant 2)
H: protein tob5 (aka protein btg3)
I: hmad-3 (aka smad3)
J: ca-ii (aka carbonic anhydrase 2)
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: btn1a1 (aka butyrophilin subfamily 1 member a1)
B: smad4/var:2 (aka smad4 sequence variant 2)
C: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
D: dwarfin-c (aka smad5)
E: streppym1-rplj (aka 50s ribosomal protein l10 (streptococcus pyogenes serotype m1))
F: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
G: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
H: isoform a (aka tgf-beta 2 isoform a)
I: c-c ckr-2 (aka c-c chemokine receptor type 2)
J: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: protein tob5 (aka protein btg3)
B: fst/iso:2/sigpep-/glycores+ (aka follistatin isoform 2, signal peptide removed glycosylated form)
C: dwarfin-c (aka smad5)
D: smad4/var:2 (aka smad4 sequence variant 2)
E: btn1a1 (aka butyrophilin subfamily 1 member a1)
F: ca-ii (aka carbonic anhydrase 2)
G: carbonic anhydrase 3 (car3 (aka carbonic anhydrase 3))
H: ddb_g0280345 (aka small glutamine-rich tetratricopeptide repeat-containing protein (dictyostelium discoideum))
I: hmad-3 (aka smad3)
J: isoform a (aka tgf-beta 2 isoform a)
K: None of the above. | K |
<Instruct>: Given the context 'Methods
Alk5/Wnt1Cre mice
Alk5 (and Alk2) mutant and control embryos were generated by mating Alk5ko/+(Alk2ko/+)/Wnt1-Cre male mice with females homozygous for the Alk5flox (Alk2flox) allele and the R26R reporter[12,19].', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
B: mumps (aka uridine 5'-monophosphate synthase (mouse))
C: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
D: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
E: eukaryotic translation initiation factor 3 subunit f (eukaryotic translation initiation factor 3 subunit 5) (aka eukaryotic translation initiation factor 3 subunit f)
F: ycjz (aka uncharacterized hth-type transcriptional regulator ycjz) (aka uncharacterized hth-type transcriptional regulator ycjz)
G: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
H: karyopherin subunit alpha-2 (schizosaccharomyces pombe 972h-) (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
I: sonic hedgehog protein n-product (shh/clv:nter) (aka sonic hedgehog protein n-product)
J: mammary tumor-associated protein int-6 (aka eukaryotic translation initiation factor 3 subunit e)
K: None of the above. | K |
<Instruct>: Given the context 'Wnt1-Cre mice were kindly provided by A. McMahon (Harvard University) and R26R reporter mice were obtained from the Jackson laboratories.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: karyopherin subunit alpha-2 (schizosaccharomyces pombe 972h-) (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
B: eukaryotic translation initiation factor 3 subunit 5 (aka eukaryotic translation initiation factor 3 subunit f)
C: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
D: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
E: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
F: uncharacterized hth-type transcriptional regulator ycjz (ycjz (aka uncharacterized hth-type transcriptional regulator ycjz))
G: shh-n (aka sonic hedgehog protein n-product)
H: mmtv integration site 6 (aka eukaryotic translation initiation factor 3 subunit e)
I: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
J: mumps (aka uridine 5'-monophosphate synthase (mouse))
K: None of the above. | K |
<Instruct>: Given the context 'For immunohistochemistry, fixed sections from tissues harvested at E10.5 – E11.5 were stained with monoclonal α-smooth muscle actin (DAKO), cleaved caspase-3 (Cell Signaling) or phophohistone-H3 (Cell Signaling) antibodies.', select the correct biomedical concept corresponding to 'h3'. Answer using one of the provided options. | <Options>: A: hpsen1/var:t245p (aka presenilin-1 sequence variant t245p (human))
B: hkbtbd12/iso:h2 (aka kelch repeat and btb domain-containing protein 12 isoform h2 (human))
C: hkbtbd12/iso:h1 (aka kelch repeat and btb domain-containing protein 12 isoform h1 (human))
D: lymphocyte expansion molecule isoform h1 (human) (hlexm/iso:h1) (aka lymphocyte expansion molecule isoform h1 (human))
E: htimm50/iso:1 (aka mitochondrial import inner membrane translocase subunit tim50 isoform 1 (human))
F: hlexm (aka lymphocyte expansion molecule (human))
G: yjef_n3 (aka yjef n-terminal domain-containing protein 3)
H: hlgalsl (aka galectin-related protein (human))
I: hanxa2r (aka annexin-2 receptor (human))
J: ras-associating and dilute domain-containing protein (kiaa1849) (aka ras-associating and dilute domain-containing protein)
K: None of the above. | K |
<Instruct>: Given the context 'For immunohistochemistry, fixed sections from tissues harvested at E10.5 – E11.5 were stained with monoclonal α-smooth muscle actin (DAKO), cleaved caspase-3 (Cell Signaling) or phophohistone-H3 (Cell Signaling) antibodies.', select the correct biomedical concept corresponding to 'α-smooth muscle actin'. Answer using one of the provided options. | <Options>: A: gdap1l (aka ganglioside-induced differentiation-associated protein 1-like 1)
B: ferm and pdz domain-containing protein 4 (human) (hfrmpd4) (aka ferm and pdz domain-containing protein 4 (human))
C: claudin-15 (human) (hcldn15) (aka claudin-15 (human))
D: ykl015w (aka proline utilization trans-activator (yeast))
E: msmo/iso:1 (aka smoothened homolog isoform 1 (mouse))
F: neurotrypsin (human) (hprss12) (aka neurotrypsin (human))
G: ganglioside-induced differentiation-associated protein 2 (gdap2) (aka ganglioside-induced differentiation-associated protein 2)
H: sbf (aka growth/differentiation factor 15) (aka growth/differentiation factor 15)
I: mkdm1a/iso:m4 (aka lysine-specific histone demethylase 1a isoform m4 (mouse))
J: hwnt2/sigpep- (aka protein wnt-2, signal peptide removed form (human))
K: None of the above. | K |
<Instruct>: Given the context 'For immunohistochemistry, fixed sections from tissues harvested at E10.5 – E11.5 were stained with monoclonal α-smooth muscle actin (DAKO), cleaved caspase-3 (Cell Signaling) or phophohistone-H3 (Cell Signaling) antibodies.', select the correct biomedical concept corresponding to 'cleaved caspase-3'. Answer using one of the provided options. | <Options>: A: smad9 isoform 3 unmodified form (smad9/iso:3/unmod) (aka smad9 isoform 3 unmodified form)
B: gtp-binding protein 7 (aka mitochondrial ribosome-associated gtpase 1)
C: cation channel sperm-associated protein 1 isoform 1 unmodified form (catsper1/iso:1/unmod) (aka cation channel sperm-associated protein 1 isoform 1 unmodified form)
D: smad6/iso:2/unmod (aka smad6 isoform 2 unmodified form)
E: metastasis-associated protein mta2 (p53 target protein in deacetylase complex) (aka metastasis-associated protein mta2)
F: lyric (aka protein lyric)
G: cyclic nucleotide-gated cation channel alpha-3 isoform 2 unmodified form (aka cyclic nucleotide-gated cation channel alpha-3 isoform m1 unmodified form)
H: mtpap (aka poly(a) rna polymerase, mitochondrial)
I: sorbs1 (aka sorbin and sh3 domain-containing protein 1)
J: caspase-1 isoform zeta (aka caspase-1 isoform 6)
K: None of the above. | K |
<Instruct>: Given the context 'Authors' contributions
J.W. did most of the mouse dissections and analyses, A.N. did some of the histological analyses, J.L. generated the Alk5FXFXmice, M.D. did some of the expression analyses, H.M.S. participated in design and provided the Tgfbr2 mutant embryos and V.K. generated the Alk2FXFX mice, designed and supervised the experiments and wrote the manuscript.', select the correct biomedical concept corresponding to 'alk5'. Answer using one of the provided options. | <Options>: A: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
B: dwarfin-c (aka smad5)
C: btn1a1 (aka butyrophilin subfamily 1 member a1)
D: faslg/iso:fasl/glycores+ (aka tumor necrosis factor ligand superfamily member 6 isoform fasl glycosylated form)
E: protein tob5 (aka protein btg3)
F: hmad-3 (aka smad3)
G: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
H: c-c ckr-2 (aka c-c chemokine receptor type 2)
I: growth/differentiation factor 5 sequence variant 2 (gdf5/var:2) (aka growth/differentiation factor 5 sequence variant 2)
J: smad4/var:2 (aka smad4 sequence variant 2)
K: None of the above. | K |
<Instruct>: Given the context 'Authors' contributions
J.W. did most of the mouse dissections and analyses, A.N. did some of the histological analyses, J.L. generated the Alk5FXFXmice, M.D. did some of the expression analyses, H.M.S. participated in design and provided the Tgfbr2 mutant embryos and V.K. generated the Alk2FXFX mice, designed and supervised the experiments and wrote the manuscript.', select the correct biomedical concept corresponding to 'alk2'. Answer using one of the provided options. | <Options>: A: spectrin beta chain, non-erythrocytic 1 isoform 2 (human) (hsptbn1/iso:2) (aka spectrin beta chain, non-erythrocytic 1 isoform 2 (human))
B: protein tob5 (aka protein btg3)
C: hmad-3 (aka smad3)
D: decorin isoform a cleaved and glycosylated form (dcn/iso:a/clvglyco+) (aka decorin isoform a cleaved and glycosylated form)
E: dwarfin-c (aka smad5)
F: ddb_g0280455 (aka activating signal cointegrator 1 complex subunit 2 homolog (dictyostelium discoideum))
G: c-c ckr-2 (aka c-c chemokine receptor type 2)
H: follistatin isoform 2, signal peptide removed glycosylated form (follistatin isoform 2 cleaved and glycosylated 1) (aka follistatin isoform 2, signal peptide removed glycosylated form)
I: btn1a1 (aka butyrophilin subfamily 1 member a1)
J: ca-ii (aka carbonic anhydrase 2)
K: None of the above. | K |
<Instruct>: Given the context 'Acknowledgements
We thank A. McMahon for providing the Wnt1-Cre mouse line, N. Manley for the PTH probe and B. Choudhary for Tgfbr2/Wnt1-Cre embryos.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
B: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
C: shh-n (aka sonic hedgehog protein n-product)
D: eukaryotic translation initiation factor 3 subunit 5 (aka eukaryotic translation initiation factor 3 subunit f)
E: viral integration site protein int-6 (aka eukaryotic translation initiation factor 3 subunit e)
F: importin-1 (schizosaccharomyces pombe 972h-) (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
G: uncharacterized hth-type transcriptional regulator ycjz (ycjz (aka uncharacterized hth-type transcriptional regulator ycjz))
H: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
I: mumps (aka uridine 5'-monophosphate synthase (mouse))
J: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
K: None of the above. | K |
<Instruct>: Given the context 'Acknowledgements
We thank A. McMahon for providing the Wnt1-Cre mouse line, N. Manley for the PTH probe and B. Choudhary for Tgfbr2/Wnt1-Cre embryos.', select the correct biomedical concept corresponding to 'wnt1'. Answer using one of the provided options. | <Options>: A: karyopherin subunit alpha-2 (schizosaccharomyces pombe 972h-) (aka importin subunit alpha-2 (schizosaccharomyces pombe 972h-))
B: viral integration site protein int-6 (aka eukaryotic translation initiation factor 3 subunit e)
C: shh-n (aka sonic hedgehog protein n-product)
D: mshh/sigpep- (aka sonic hedgehog protein, signal peptide removed form (mouse))
E: mumps (aka uridine 5'-monophosphate synthase (mouse))
F: uncharacterized hth-type transcriptional regulator ycjz (ycjz (aka uncharacterized hth-type transcriptional regulator ycjz))
G: rna exonuclease 4 (schizosaccharomyces pombe 972h-) (spom972h-rex4) (aka rna exonuclease 4 (schizosaccharomyces pombe 972h-))
H: eukaryotic translation initiation factor 3 subunit f (eukaryotic translation initiation factor 3 subunit 5) (aka eukaryotic translation initiation factor 3 subunit f)
I: ec-hdha (aka 7-alpha-hydroxysteroid dehydrogenase (escherichia coli k-12))
J: eukaryotic translation initiation factor 3 subunit 1 (aka eukaryotic translation initiation factor 3 subunit j)
K: None of the above. | K |
<Instruct>: Given the context 'RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
Abstract
In recent years, tremendous insight has been gained on p53 regulation by targeting mutations at the p53 locus using homologous recombination in ES cells to generate mutant mice.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: actp10 (aka adenylate cyclase type 9)
H: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
Abstract
In recent years, tremendous insight has been gained on p53 regulation by targeting mutations at the p53 locus using homologous recombination in ES cells to generate mutant mice.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'To facilitate targeting at the p53 locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: pacap (aka pituitary adenylate cyclase-activating polypeptide)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We provide proof-of-concept for this at the p53 locus, by showing efficient targeting in fibroblasts, and rapid phenotypic read-out of a recessive mutation after a single exchange.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: actp10 (aka adenylate cyclase type 9)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: ec-motb (aka motility protein b (escherichia coli k-12))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'INTRODUCTION
p53 is one of the most highly analyzed proteins for the past 25 years.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: adcy9 (aka adenylate cyclase type 9)
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Studies in cultured cells, often relying on the transfection of plasmids expressing various p53 mutants, have established models to explain how p53 is regulated.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: kiaa0520 (aka adenylate cyclase type 9)
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'Studies in cultured cells, often relying on the transfection of plasmids expressing various p53 mutants, have established models to explain how p53 is regulated.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
G: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: adenylyl cyclase 9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'In recent years, some of these models were tested in vivo by targeting subtle mutations at the p53 locus using homologous recombination in embryonic stem (ES) cells to generate mutant mice.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: actp10 (aka adenylate cyclase type 9)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'As significant differences between phenotypes from targeted p53 mutants in vivo and transfection data were observed [e.g. Refs (1–5)], more targeted mutations need to be generated and analyzed in multiple tissues to formulate more accurate models of p53 regulation.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: adcy9 (aka adenylate cyclase type 9)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'As significant differences between phenotypes from targeted p53 mutants in vivo and transfection data were observed [e.g. Refs (1–5)], more targeted mutations need to be generated and analyzed in multiple tissues to formulate more accurate models of p53 regulation.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pacap (aka pituitary adenylate cyclase-activating polypeptide)
E: actp10 (aka adenylate cyclase type 9)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Improvements in current technologies are needed to enable such analyses to be applied to the p53 or other genes.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ec-motb (aka motility protein b (escherichia coli k-12))
E: pacap (aka pituitary adenylate cyclase-activating polypeptide)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: actp10 (aka adenylate cyclase type 9)
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Here we report an approach that enables highly efficient targeting at the p53 locus in both ES cells and fibroblasts.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: pacap (aka pituitary adenylate cyclase-activating polypeptide)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: actp10 (aka adenylate cyclase type 9)
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We show that our approach enables efficient targeting of marker-free mutations at the p53 locus in ES cells to generate mutant mice, but more importantly, it is Adapted for targeting in Somatic cells to Accelerate Phenotyping (ASAP).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: adcy9 (aka adenylate cyclase type 9)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'MATERIALS AND METHODS
Targeting construct for a p53 RMCE-ready locus
Details for plasmid construction are available upon request owing to space limitations mandating a brief outline.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: actp10 (aka adenylate cyclase type 9)
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Next, a PmlI-MfeI 6.3 kb fragment from Trp53 was subcloned in a modified pBluescript KSII+ (pBS, Stratagene), and the resulting plasmid was digested with SwaI to introduce an EagI site, leading to p53PmlEag, a plasmid containing exons 2–11 of p53.', select the correct biomedical concept corresponding to 'trp53'. Answer using one of the provided options. | <Options>: A: nitrate/nitrite response regulator protein narl (escherichia coli k-12) (ec-narl) (aka nitrate/nitrite response regulator protein narl (escherichia coli k-12))
B: ec-zapb (aka cell division protein zapb (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: proteasome activator complex subunit 3 (human) (hpsme3) (aka proteasome activator complex subunit 3 (human))
H: patz1 (aka poz-, at hook-, and zinc finger-containing protein 1)
I: kiaa0520 (aka adenylate cyclase type 9)
J: mrnf169 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
K: None of the above. | K |
<Instruct>: Given the context 'Next, a PmlI-MfeI 6.3 kb fragment from Trp53 was subcloned in a modified pBluescript KSII+ (pBS, Stratagene), and the resulting plasmid was digested with SwaI to introduce an EagI site, leading to p53PmlEag, a plasmid containing exons 2–11 of p53.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: kiaa0520 (aka adenylate cyclase type 9)
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'We then inserted a 5.5 kb ClaI-EagI fragment from p53PmlEag in plasmid CN-PuroΔTK-F digested by ClaI and NotI, and inserted the resulting fragment between the loxP sites of L3-CF-1L by ClaI and FseI digestion, leading to L3-p53PmlEagPuroΔTK-1L. We next engineered a plasmid containing the region for 3′-homology downstream of the p53 gene and the DTA gene in two steps: (i) we performed a three-way ligation between a modified pBS digested by HindIII and NotI, a HindIII-EcoRI fragment from Trp53 for 3′homology and an EcoRI-NotI fragment containing the DTA gene, from plasmid pgkdtabpa (kind gift of P. Soriano), leading to plasmid 3′ + DTA and (ii) because the Bsu36I-EcoRI region downstream of p53 contains repetitive sequences (F. Toledo and G. M. Wahl, unpublished data), we later deleted this region, to obtain plasmid 3′ + DTA.', select the correct biomedical concept corresponding to 'hindiii'. Answer using one of the provided options. | <Options>: A: psid (aka phosphonates-binding periplasmic protein) (aka phosphonates-binding periplasmic protein)
B: ydip5 (aka dicarboxylic amino acid permease (yeast))
C: map7d2 (aka map7 domain-containing protein 2)
D: ec-yfex (aka deferrochelatase/peroxidase yfex (escherichia coli k-12))
E: su(fu)-xl (aka suppressor of fused homolog isoform 4)
F: protein cation/h+ exchanger 24 (arabidopsis thaliana) (aka cation/h(+) antiporter 24 (arabidopsis thaliana))
G: hsftpc (aka pulmonary surfactant-associated protein c (human))
H: mln 137 (aka keratin, type ii cuticular hb1)
I: epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human) (heps8l2/iso:h1) (aka epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human))
J: kctd2 (aka btb/poz domain-containing protein kctd2)
K: None of the above. | K |
<Instruct>: Given the context 'We then inserted a 5.5 kb ClaI-EagI fragment from p53PmlEag in plasmid CN-PuroΔTK-F digested by ClaI and NotI, and inserted the resulting fragment between the loxP sites of L3-CF-1L by ClaI and FseI digestion, leading to L3-p53PmlEagPuroΔTK-1L. We next engineered a plasmid containing the region for 3′-homology downstream of the p53 gene and the DTA gene in two steps: (i) we performed a three-way ligation between a modified pBS digested by HindIII and NotI, a HindIII-EcoRI fragment from Trp53 for 3′homology and an EcoRI-NotI fragment containing the DTA gene, from plasmid pgkdtabpa (kind gift of P. Soriano), leading to plasmid 3′ + DTA and (ii) because the Bsu36I-EcoRI region downstream of p53 contains repetitive sequences (F. Toledo and G. M. Wahl, unpublished data), we later deleted this region, to obtain plasmid 3′ + DTA.', select the correct biomedical concept corresponding to 'hindiii'. Answer using one of the provided options. | <Options>: A: dicarboxylic amino acid permease (yeast) (ypl265w) (aka dicarboxylic amino acid permease (yeast))
B: hsftpc (aka pulmonary surfactant-associated protein c (human))
C: mfgfbp3 (aka fibroblast growth factor-binding protein 3 (mouse))
D: mln 137 (aka keratin, type ii cuticular hb1)
E: su(fu)-xl (aka suppressor of fused homolog isoform 4)
F: ubxd7 (aka ubx domain-containing protein 7)
G: epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human) (heps8l2/iso:h1) (aka epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human))
H: ec-yfex (aka deferrochelatase/peroxidase yfex (escherichia coli k-12))
I: map7 domain-containing protein 2 (map7d2) (aka map7 domain-containing protein 2)
J: psid (aka phosphonates-binding periplasmic protein) (aka phosphonates-binding periplasmic protein)
K: None of the above. | K |
<Instruct>: Given the context 'We then inserted a 5.5 kb ClaI-EagI fragment from p53PmlEag in plasmid CN-PuroΔTK-F digested by ClaI and NotI, and inserted the resulting fragment between the loxP sites of L3-CF-1L by ClaI and FseI digestion, leading to L3-p53PmlEagPuroΔTK-1L. We next engineered a plasmid containing the region for 3′-homology downstream of the p53 gene and the DTA gene in two steps: (i) we performed a three-way ligation between a modified pBS digested by HindIII and NotI, a HindIII-EcoRI fragment from Trp53 for 3′homology and an EcoRI-NotI fragment containing the DTA gene, from plasmid pgkdtabpa (kind gift of P. Soriano), leading to plasmid 3′ + DTA and (ii) because the Bsu36I-EcoRI region downstream of p53 contains repetitive sequences (F. Toledo and G. M. Wahl, unpublished data), we later deleted this region, to obtain plasmid 3′ + DTA.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: kiaa0520 (aka adenylate cyclase type 9)
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'We then inserted a 5.5 kb ClaI-EagI fragment from p53PmlEag in plasmid CN-PuroΔTK-F digested by ClaI and NotI, and inserted the resulting fragment between the loxP sites of L3-CF-1L by ClaI and FseI digestion, leading to L3-p53PmlEagPuroΔTK-1L. We next engineered a plasmid containing the region for 3′-homology downstream of the p53 gene and the DTA gene in two steps: (i) we performed a three-way ligation between a modified pBS digested by HindIII and NotI, a HindIII-EcoRI fragment from Trp53 for 3′homology and an EcoRI-NotI fragment containing the DTA gene, from plasmid pgkdtabpa (kind gift of P. Soriano), leading to plasmid 3′ + DTA and (ii) because the Bsu36I-EcoRI region downstream of p53 contains repetitive sequences (F. Toledo and G. M. Wahl, unpublished data), we later deleted this region, to obtain plasmid 3′ + DTA.', select the correct biomedical concept corresponding to 'trp53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: nitrate/nitrite response regulator protein narl (escherichia coli k-12) (ec-narl) (aka nitrate/nitrite response regulator protein narl (escherichia coli k-12))
D: ec-zapb (aka cell division protein zapb (escherichia coli k-12))
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: pacap (aka pituitary adenylate cyclase-activating polypeptide)
I: mrnf169 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: patz1 (aka poz-, at hook-, and zinc finger-containing protein 1)
K: None of the above. | K |
<Instruct>: Given the context 'We then inserted a 5.5 kb ClaI-EagI fragment from p53PmlEag in plasmid CN-PuroΔTK-F digested by ClaI and NotI, and inserted the resulting fragment between the loxP sites of L3-CF-1L by ClaI and FseI digestion, leading to L3-p53PmlEagPuroΔTK-1L. We next engineered a plasmid containing the region for 3′-homology downstream of the p53 gene and the DTA gene in two steps: (i) we performed a three-way ligation between a modified pBS digested by HindIII and NotI, a HindIII-EcoRI fragment from Trp53 for 3′homology and an EcoRI-NotI fragment containing the DTA gene, from plasmid pgkdtabpa (kind gift of P. Soriano), leading to plasmid 3′ + DTA and (ii) because the Bsu36I-EcoRI region downstream of p53 contains repetitive sequences (F. Toledo and G. M. Wahl, unpublished data), we later deleted this region, to obtain plasmid 3′ + DTA.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: pacap (aka pituitary adenylate cyclase-activating polypeptide)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: kiaa0520 (aka adenylate cyclase type 9)
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'The 5′ homology consists of a 3.4 kb-long BamHI-PmlI fragment from intron 1 of p53 cloned in a modified pBS (plasmid p5′).', select the correct biomedical concept corresponding to 'bamhi'. Answer using one of the provided options. | <Options>: A: protein wnt-3a isoform 2 (chicken) (chick-wnt3a/iso:2) (aka protein wnt-3a isoform 2 (chicken))
B: olfactory receptor 11h2 (olfactory receptor or14-1) (aka olfactory receptor 11h2)
C: worm-air-2 (aka aurora/ipl1-related protein kinase 2 (caenorhabditis elegans))
D: btb/poz domain-containing protein kctd2 (potassium channel tetramerization domain-containing protein 2) (aka btb/poz domain-containing protein kctd2)
E: tas2r55 (aka taste receptor type 2 member 42)
F: mapt/iso:tau-a (aka microtubule-associated protein tau isoform tau-a)
G: e3 ubiquitin-protein ligase lnx isoform lnx-b (mouse) (aka e3 ubiquitin-protein ligase lnx isoform m2 (mouse))
H: hfra10ac1/iso:h5 (aka protein fra10ac1 isoform h5 (human))
I: testin-2 (rat) (cmb-23 (rat)) (aka testin-2 (rat))
J: c2orf84 (aka protein fam228a)
K: None of the above. | K |
<Instruct>: Given the context 'The 5′ homology consists of a 3.4 kb-long BamHI-PmlI fragment from intron 1 of p53 cloned in a modified pBS (plasmid p5′).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: adenylyl cyclase 9 (aka adenylate cyclase type 9)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Plasmid Flox, the resulting targeting construct, was verified by restriction analysis, then sequenced using 30 primers chosen to precisely verify all p53 coding sequences, all exon–intron junctions and the sequences at and around the loxP sites.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-motb (aka motility protein b (escherichia coli k-12))
G: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'hindiii'. Answer using one of the provided options. | <Options>: A: ypl265w (aka dicarboxylic amino acid permease (yeast))
B: su(fu)-xl (aka suppressor of fused homolog isoform 4)
C: ec-yfex (aka deferrochelatase/peroxidase yfex (escherichia coli k-12))
D: mfgfbp3 (aka fibroblast growth factor-binding protein 3 (mouse))
E: hsftpc (aka pulmonary surfactant-associated protein c (human))
F: kiaa0794 (aka ubx domain-containing protein 7)
G: psid (aka phosphonates-binding periplasmic protein) (aka phosphonates-binding periplasmic protein)
H: uncharacterized protein yfey (escherichia coli k-12) (ec-yfey) (aka uncharacterized protein yfey (escherichia coli k-12))
I: mln 137 (aka keratin, type ii cuticular hb1)
J: map7d2 (aka map7 domain-containing protein 2)
K: None of the above. | K |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'hindiii'. Answer using one of the provided options. | <Options>: A: hsftpc (aka pulmonary surfactant-associated protein c (human))
B: mfgfbp3 (aka fibroblast growth factor-binding protein 3 (mouse))
C: atchx24 (arabidopsis thaliana) (aka cation/h(+) antiporter 24 (arabidopsis thaliana))
D: mln 137 (aka keratin, type ii cuticular hb1)
E: su(fu)-xl (aka suppressor of fused homolog isoform 4)
F: epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human) (heps8l2/iso:h1) (aka epidermal growth factor receptor kinase substrate 8-like protein 2 isoform h1 (human))
G: ypl265w (aka dicarboxylic amino acid permease (yeast))
H: kctd2 (aka btb/poz domain-containing protein kctd2)
I: psid (aka phosphonates-binding periplasmic protein) (aka phosphonates-binding periplasmic protein)
J: kiaa0794 (aka ubx domain-containing protein 7)
K: None of the above. | K |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: actp10 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: actp10 (aka adenylate cyclase type 9)
H: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Exchange constructs: making the p53GFP and p53ΔPGFP plasmids
To make a p53-GFP fusion protein, we first subcloned a SacII-HindIII fragment of the p53 locus (corresponding to part of exon 10 to sequences downstream of the gene) into pBS, then mutated the HindIII site into a FseI site.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: actp10 (aka adenylate cyclase type 9)
H: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We next mutated the C-terminal part of the p53 gene in two rounds of PCR mutagenesis, first with primers 5′-GGGCCTGACTCAGACGGATCCCCTCTGCATCCCGTC-3′ and 5′-GACGGGATGCAGAGGGGATCCGTCTGAGTCAGGCCC-3′, which removed the stop codon and introduced a BamHI site, then with primers 5′-GACGGATCCCCTCTGAATTCCGTCCCCATCACCA-3′ and 5′-TGGTGATGGGGACGGAATACAGAGGGGATCCGTC-3′, which introduced an EcoRI site.', select the correct biomedical concept corresponding to 'bamhi'. Answer using one of the provided options. | <Options>: A: protein wnt-3a isoform 2 (chicken) (chick-wnt3a/iso:2) (aka protein wnt-3a isoform 2 (chicken))
B: olfactory receptor or14-1 (aka olfactory receptor 11h2)
C: silv/full (aka melanocyte protein pmel 17, full-length form)
D: crp810_1.4 (aka protein lure 1.4 (arabidopsis thaliana))
E: testin-2 (rat) (cmb-23 (rat)) (aka testin-2 (rat))
F: e3 ubiquitin-protein ligase lnx isoform lnx-b (mouse) (aka e3 ubiquitin-protein ligase lnx isoform m2 (mouse))
G: worm-air-2 (aka aurora/ipl1-related protein kinase 2 (caenorhabditis elegans))
H: homeobox protein aristaless-like 3 (human) (halx3) (aka homeobox protein aristaless-like 3 (human))
I: tas2r55 (aka taste receptor type 2 member 42)
J: ydr448w (aka transcriptional adapter 2 (yeast))
K: None of the above. | K |
<Instruct>: Given the context 'We next mutated the C-terminal part of the p53 gene in two rounds of PCR mutagenesis, first with primers 5′-GGGCCTGACTCAGACGGATCCCCTCTGCATCCCGTC-3′ and 5′-GACGGGATGCAGAGGGGATCCGTCTGAGTCAGGCCC-3′, which removed the stop codon and introduced a BamHI site, then with primers 5′-GACGGATCCCCTCTGAATTCCGTCCCCATCACCA-3′ and 5′-TGGTGATGGGGACGGAATACAGAGGGGATCCGTC-3′, which introduced an EcoRI site.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'We verified the sequence from the mutated plasmid, then digested it with BamHI and EcoRI, to insert in frame GFP sequences from a Bam HI-EcoRI fragment of plasmid phr-GFP-1 (Stratagene).', select the correct biomedical concept corresponding to 'bamhi'. Answer using one of the provided options. | <Options>: A: homeobox protein aristaless-like 3 (human) (halx3) (aka homeobox protein aristaless-like 3 (human))
B: protein wnt-3a isoform 2 (chicken) (chick-wnt3a/iso:2) (aka protein wnt-3a isoform 2 (chicken))
C: glypican-1 proteolytic cleavage product (gpc1/clvprd) (aka glypican-1 proteolytic cleavage product)
D: worm-air-2 (aka aurora/ipl1-related protein kinase 2 (caenorhabditis elegans))
E: tas2r55 (aka taste receptor type 2 member 42)
F: btb/poz domain-containing protein kctd2 (potassium channel tetramerization domain-containing protein 2) (aka btb/poz domain-containing protein kctd2)
G: at5g43518 (aka protein lure 1.4 (arabidopsis thaliana))
H: olfactory receptor 11h2 (olfactory receptor or14-1) (aka olfactory receptor 11h2)
I: testin-2 (rat) (cmb-23 (rat)) (aka testin-2 (rat))
J: c2orf84 (aka protein fam228a)
K: None of the above. | K |
<Instruct>: Given the context 'We verified the sequence from the mutated plasmid, then digested it with BamHI and EcoRI, to insert in frame GFP sequences from a Bam HI-EcoRI fragment of plasmid phr-GFP-1 (Stratagene).', select the correct biomedical concept corresponding to 'bam hi'. Answer using one of the provided options. | <Options>: A: tripartite motif-containing protein 42 (trim42) (aka tripartite motif-containing protein 42)
B: karyopherin subunit alpha (yeast) (aka importin subunit alpha (yeast))
C: platelet-derived growth factor c isoform 1 sumoylated 1 (human) (uniprotkb:q9nra1-1, lys-314, mod:01149) (aka platelet-derived growth factor c isoform 1 sumoylated 1 (human))
D: mpdgfc/iso:1/clv:1 (aka platelet-derived growth factor c isoform 1 cleaved 1 (mouse))
E: f-atpase gamma subunit (aka atp synthase subunit gamma, mitochondrial)
F: olfactory receptor 52a3 (aka olfactory receptor 51e1)
G: 6-phosphofructokinase complex, platelet-type homotetramer (aka 6-phosphofructokinase complex, type c homotetramer)
H: calmodulin-related protein nb-1 (aka calmodulin-like protein 3)
I: uncharacterized protein b0302.2 (caenorhabditis elegans) (worm-b0302.2) (aka uncharacterized protein b0302.2 (caenorhabditis elegans))
J: nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (human) (hndufs1) (aka nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (human))
K: None of the above. | K |
<Instruct>: Given the context 'We verified the sequence of this p53-GFP fusion fragment, then swapped it in the L3-p53PmlEagPuroΔTK-1L plasmid (see above) by HindIII and FseI digestion, resulting in the p53GFP exchange construct, the sequence which was verified before use.', select the correct biomedical concept corresponding to 'hindiii'. Answer using one of the provided options. | <Options>: A: uncharacterized protein yfey (escherichia coli k-12) (ec-yfey) (aka uncharacterized protein yfey (escherichia coli k-12))
B: mln 137 (aka keratin, type ii cuticular hb1)
C: psid (aka phosphonates-binding periplasmic protein) (aka phosphonates-binding periplasmic protein)
D: protein cation/h+ exchanger 24 (arabidopsis thaliana) (aka cation/h(+) antiporter 24 (arabidopsis thaliana))
E: kiaa0794 (aka ubx domain-containing protein 7)
F: kctd2 (aka btb/poz domain-containing protein kctd2)
G: ec-yfex (aka deferrochelatase/peroxidase yfex (escherichia coli k-12))
H: map7d2 (aka map7 domain-containing protein 2)
I: hsftpc (aka pulmonary surfactant-associated protein c (human))
J: fgfbp-3 (mouse) (aka fibroblast growth factor-binding protein 3 (mouse))
K: None of the above. | K |
<Instruct>: Given the context 'We verified the sequence of this p53-GFP fusion fragment, then swapped it in the L3-p53PmlEagPuroΔTK-1L plasmid (see above) by HindIII and FseI digestion, resulting in the p53GFP exchange construct, the sequence which was verified before use.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: actp10 (aka adenylate cyclase type 9)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We verified the sequence of this p53-GFP fusion fragment, then swapped it in the L3-p53PmlEagPuroΔTK-1L plasmid (see above) by HindIII and FseI digestion, resulting in the p53GFP exchange construct, the sequence which was verified before use.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: actp10 (aka adenylate cyclase type 9)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'The p53ΔPGFP exchange construct was engineered by combining sequences from the p53GFP exchange plasmid and sequences from the p53ΔP targeting construct described recently (5).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: actp10 (aka adenylate cyclase type 9)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: pacap (aka pituitary adenylate cyclase-activating polypeptide)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'The p53ΔPGFP exchange construct was engineered by combining sequences from the p53GFP exchange plasmid and sequences from the p53ΔP targeting construct described recently (5).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: actp10 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'The p53ΔPGFP exchange construct was engineered by combining sequences from the p53GFP exchange plasmid and sequences from the p53ΔP targeting construct described recently (5).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: actp10 (aka adenylate cyclase type 9)
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: kiaa0520 (aka adenylate cyclase type 9)
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: ec-motb (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: actp10 (aka adenylate cyclase type 9)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: kiaa0520 (aka adenylate cyclase type 9)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: pacap (aka pituitary adenylate cyclase-activating polypeptide)
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pacap (aka pituitary adenylate cyclase-activating polypeptide)
G: actp10 (aka adenylate cyclase type 9)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcy9 (aka adenylate cyclase type 9)
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
F: kiaa0520 (aka adenylate cyclase type 9)
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
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