instruction stringlengths 142 1.78k | input stringlengths 321 1.59k | response stringclasses 11 values |
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<Instruct>: Given the context 'Western analysis of positive clones (bottom row) showed that p53ΔPGFP accumulated after ADR, but at lower levels than p53WT.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: kiaa0520 (aka adenylate cyclase type 9)
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context '(C) Phenotypic assay of p53ΔPGFP: loss of cell cycle control.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Asynchronous p53RMCE/− and p53ΔPGFP/− MEFs left untreated, or irradiated with doses of 6 or 12 Gy, were analyzed (top shows a typical experiment; bottom plots results from ≥4 independent experiments and ≥3 independent MEFs).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: pacap (aka pituitary adenylate cyclase-activating polypeptide)
F: kiaa0520 (aka adenylate cyclase type 9)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Asynchronous p53RMCE/− and p53ΔPGFP/− MEFs left untreated, or irradiated with doses of 6 or 12 Gy, were analyzed (top shows a typical experiment; bottom plots results from ≥4 independent experiments and ≥3 independent MEFs).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: kiaa0520 (aka adenylate cyclase type 9)
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: pacap (aka pituitary adenylate cyclase-activating polypeptide)
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Note that the p53RMCE locus encodes a WT p53.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: adenylyl cyclase 9 (aka adenylate cyclase type 9)
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Note that the p53RMCE locus encodes a WT p53.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: adenylyl cyclase 9 (aka adenylate cyclase type 9)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Table 1
Summary of targeting experiments
In ES cells, targeting p53ΔPGFP or p53GFP by RMCE was ∼20 times more efficient than targeting Flox by homologous recombination.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: kiaa0520 (aka adenylate cyclase type 9)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Table 1
Summary of targeting experiments
In ES cells, targeting p53ΔPGFP or p53GFP by RMCE was ∼20 times more efficient than targeting Flox by homologous recombination.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: kiaa0520 (aka adenylate cyclase type 9)
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'In MEFs, due to p53GFP toxicity, only the targeting efficiency of RMCE with p53ΔPGFP could be evaluated.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: adenylyl cyclase 9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'In MEFs, due to p53GFP toxicity, only the targeting efficiency of RMCE with p53ΔPGFP could be evaluated.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: actp10 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Importantly, a phenotypic read-out of the p53ΔPGFP mutation in MEFs, if it had been performed after targeting in fibroblasts by homologous recombination, would have required two rounds of inefficient targeting to target both p53 alleles.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: adenylyl cyclase 9 (aka adenylate cyclase type 9)
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Importantly, a phenotypic read-out of the p53ΔPGFP mutation in MEFs, if it had been performed after targeting in fibroblasts by homologous recombination, would have required two rounds of inefficient targeting to target both p53 alleles.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: actp10 (aka adenylate cyclase type 9)
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Previously described retinal degeneration [[81]] caused by homozygosity for the Pde6brd1mutation was noted in strains SB/Le, ST/bJ, BUB/BnJ, CBA/J, C3H/HeJ, SJL/J and SWR/J.
Strain differences are reproducible
To assess the consistency of IOP in specific strains, we measured IOP in different cohorts of each strain maintained under similar conditions at different times.', select the correct biomedical concept corresponding to 'pde6b'. Answer using one of the provided options. | <Options>: A: hpsen1/var:t354i (aka presenilin-1 sequence variant t354i (human))
B: fbp30 (aka formin-binding protein 4)
C: fad104 (aka fibronectin type iii domain-containing protein 3b)
D: formin-binding protein 17 (aka formin-binding protein 1)
E: kiaa1450 (aka folliculin-interacting protein 2)
F: hemg (aka protoporphyrinogen oxidase (bacillus subtilis subsp. subtilis str. 168)) (aka protoporphyrinogen oxidase (bacillus subtilis subsp. subtilis str. 168))
G: fhod3 (aka formin-like protein 3)
H: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (fnta (aka protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha))
I: fly-arp3 (aka actin-related protein 3 (fruit fly))
J: fn3krp (aka ketosamine-3-kinase)
K: None of the above. | K |
<Instruct>: Given the context 'Myoc alleles do not associate with the magnitude of IOP
Mutations in the myocilin gene (MYOC) cause human glaucoma.', select the correct biomedical concept corresponding to 'myocilin'. Answer using one of the provided options. | <Options>: A: at-cpk15 (aka calcium-dependent protein kinase 15 (arabidopsis thaliana))
B: ctsk/clvprd (aka cathepsin k proteolytic cleavage product)
C: cd14 molecule, full-length form (cd14/full) (aka cd14 molecule, full-length form)
D: u11/u12 small nuclear ribonucleoprotein 59 kda protein (arabidopsis thaliana) (u11/u12 snrnp 59 kda protein (arabidopsis thaliana)) (aka u11/u12 small nuclear ribonucleoprotein 59 kda protein (arabidopsis thaliana))
E: fractalkine, signal peptide removed form (cx3cl1/sigpep-) (aka fractalkine, signal peptide removed form)
F: at5g39100 (aka germin-like protein subfamily 1 member 13 (arabidopsis thaliana))
G: major prion protein, full-length form (prnp/full) (aka major prion protein, full-length form)
H: at-gpl1 (aka glabrous1 enhancer-binding protein-like 1 (arabidopsis thaliana))
I: lepr/sigpep- (aka leptin receptor, signal peptide removed form)
J: fractalkine, full-length form (cx3cl1/full) (aka fractalkine, full-length form)
K: None of the above. | K |
<Instruct>: Given the context 'Myoc alleles do not associate with the magnitude of IOP
Mutations in the myocilin gene (MYOC) cause human glaucoma.', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: cpne3/initmet- (aka copine-3, initiator methionine removed form)
B: cpox/full (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
C: spom972h-abhd4 (aka cardiolipin-specific deacylase, mitochondrial (schizosaccharomyces pombe 972h-))
D: spn/full (aka leukosialin, full-length form)
E: hirf6/iso:1 (aka interferon regulatory factor 6 isoform 1 (human))
F: lbp/sigpep- (aka lipopolysaccharide-binding protein, signal peptide removed form)
G: lag3/full (aka lymphocyte activation gene 3 protein, full-length form)
H: olfactory receptor 2b5 (aka olfactory receptor 2b6)
I: il10/sigpep- (aka interleukin-10, signal peptide removed form)
J: transmembrane 4 l6 family member 5 (human) (htm4sf5) (aka transmembrane 4 l6 family member 5 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Myoc alleles do not associate with the magnitude of IOP
Mutations in the myocilin gene (MYOC) cause human glaucoma.', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: transmembrane 4 l6 family member 5 (human) (htm4sf5) (aka transmembrane 4 l6 family member 5 (human))
B: nt5e/clvprd (aka 5'-nucleotidase proteolytic cleavage product)
C: copine-3, initiator methionine removed form (cpne3/initmet-) (aka copine-3, initiator methionine removed form)
D: hirf6/iso:1 (aka interferon regulatory factor 6 isoform 1 (human))
E: cpox/full (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
F: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
G: lbp/sigpep- (aka lipopolysaccharide-binding protein, signal peptide removed form)
H: spom972h-abhd4 (aka cardiolipin-specific deacylase, mitochondrial (schizosaccharomyces pombe 972h-))
I: cxcl16/full (aka c-x-c motif chemokine 16, full-length form)
J: krueppel-like factor 11 isoform h2 (human) (hklf11/iso:h2) (aka krueppel-like factor 11 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To determine if allelic variation in the mouse Myoc gene associated with IOP in mouse strains, we analyzed the gene in an assortment of strains with different IOPs.', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
B: spom972h-abhd4 (aka cardiolipin-specific deacylase, mitochondrial (schizosaccharomyces pombe 972h-))
C: oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form (cpox/full) (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
D: nt5e/clvprd (aka 5'-nucleotidase proteolytic cleavage product)
E: olfactory receptor 2b5 (aka olfactory receptor 2b6)
F: hgemin2/iso:h4 (aka gem-associated protein 2 isoform h4 (human))
G: lbp/sigpep- (aka lipopolysaccharide-binding protein, signal peptide removed form)
H: major prion protein, full-length form (prnp/full) (aka major prion protein, full-length form)
I: krueppel-like factor 11 isoform h2 (human) (hklf11/iso:h2) (aka krueppel-like factor 11 isoform h2 (human))
J: il10/sigpep- (aka interleukin-10, signal peptide removed form)
K: None of the above. | K |
<Instruct>: Given the context 'Figure 8
Myoc alleles do not associate with IOP. ', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
B: hirf6/iso:1 (aka interferon regulatory factor 6 isoform 1 (human))
C: nt5e/clvprd (aka 5'-nucleotidase proteolytic cleavage product)
D: krueppel-like factor 11 isoform h2 (human) (hklf11/iso:h2) (aka krueppel-like factor 11 isoform h2 (human))
E: carboxypeptidase n catalytic chain, signal peptide removed form (cpn1/sigpep-) (aka carboxypeptidase n catalytic chain, signal peptide removed form)
F: lbp/sigpep- (aka lipopolysaccharide-binding protein, signal peptide removed form)
G: spom972h-abhd4 (aka cardiolipin-specific deacylase, mitochondrial (schizosaccharomyces pombe 972h-))
H: spn/full (aka leukosialin, full-length form)
I: cpox/full (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
J: olfactory receptor 2b5 (aka olfactory receptor 2b6)
K: None of the above. | K |
<Instruct>: Given the context 'Sequencing identified two alleles of Myoc in these mouse strains (see text).', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: major prion protein, full-length form (prnp/full) (aka major prion protein, full-length form)
B: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
C: spn/full (aka leukosialin, full-length form)
D: olfactory receptor 2b5 (aka olfactory receptor 2b6)
E: hirf6/iso:1 (aka interferon regulatory factor 6 isoform 1 (human))
F: krueppel-like factor 11 isoform h2 (human) (hklf11/iso:h2) (aka krueppel-like factor 11 isoform h2 (human))
G: cpne3/initmet- (aka copine-3, initiator methionine removed form)
H: transmembrane 4 l6 family member 5 (human) (htm4sf5) (aka transmembrane 4 l6 family member 5 (human))
I: lag3/full (aka lymphocyte activation gene 3 protein, full-length form)
J: cpn1/sigpep- (aka carboxypeptidase n catalytic chain, signal peptide removed form)
K: None of the above. | K |
<Instruct>: Given the context 'The IOP increase in the dark is not dependent on functional rod and cone photoreceptors since these cells degenerate in SWR/J mice due to homozygosity for the Pde6brd1 mutation.', select the correct biomedical concept corresponding to 'pde6b'. Answer using one of the provided options. | <Options>: A: fbp30 (aka formin-binding protein 4)
B: fmo1 (aka dimethylaniline monooxygenase [n-oxide-forming] 1) (aka dimethylaniline monooxygenase [n-oxide-forming] 1)
C: kiaa1450 (aka folliculin-interacting protein 2)
D: hpsen1/var:t354i (aka presenilin-1 sequence variant t354i (human))
E: dimethylaniline monooxygenase [n-oxide-forming] 4 (fmo2 (aka dimethylaniline monooxygenase [n-oxide-forming] 4))
F: formin-binding protein 17 (aka formin-binding protein 1)
G: fndc2 (aka fibronectin type iii domain-containing protein 1)
H: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (fnta (aka protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha))
I: fhod3 (aka formin-like protein 3)
J: actr66b (aka actin-related protein 3 (fruit fly))
K: None of the above. | K |
<Instruct>: Given the context 'CAIV activity was recently demonstrated in the ciliary processes [73] and so our data may support a more substantial role for CAIV compared to CAII in aqueous humor secretion.', select the correct biomedical concept corresponding to 'caiv'. Answer using one of the provided options. | <Options>: A: raig2 (aka g-protein coupled receptor family c group 5 member b)
B: tim22 (aka mitochondrial import inner membrane translocase subunit tim22)
C: raig-1 (aka retinoic acid-induced protein 3)
D: gprc5d (aka g-protein coupled receptor family c group 5 member d)
E: kiaa0686 (aka g-protein coupled receptor 98)
F: gprc5c (aka g-protein coupled receptor family c group 5 member c)
G: cop9 signalosome complex subunit 1 (gps1 (aka cop9 signalosome complex subunit 1))
H: activator of g-protein signaling 3 (aka g-protein-signaling modulator 1)
I: gprasp1 (aka g-protein coupled receptor-associated sorting protein 1)
J: kiaa0514 (aka g protein-regulated inducer of neurite outgrowth 2)
K: None of the above. | K |
<Instruct>: Given the context 'CAIV activity was recently demonstrated in the ciliary processes [73] and so our data may support a more substantial role for CAIV compared to CAII in aqueous humor secretion.', select the correct biomedical concept corresponding to 'caiv'. Answer using one of the provided options. | <Options>: A: sgn1 (aka cop9 signalosome complex subunit 1) (aka cop9 signalosome complex subunit 1)
B: dna repair protein b (dictyostelium discoideum) (aka tfiih basal transcription factor complex helicase repb subunit (dictyostelium discoideum))
C: gasp-1 (aka g-protein coupled receptor-associated sorting protein 1)
D: raig-1 (aka retinoic acid-induced protein 3)
E: tim22 (aka mitochondrial import inner membrane translocase subunit tim22)
F: gprc5d (aka g-protein coupled receptor family c group 5 member d)
G: raig2 (aka g-protein coupled receptor family c group 5 member b)
H: kiaa0686 (aka g-protein coupled receptor 98)
I: kiaa0514 (aka g protein-regulated inducer of neurite outgrowth 2)
J: gprc5c (aka g-protein coupled receptor family c group 5 member c)
K: None of the above. | K |
<Instruct>: Given the context 'It also is possible that CAII substantially contributes to aqueous humor secretion but that functional mouse CAIV is sufficient to prevent an effect of CAII deficiency on IOP in Car2 mutant mice.', select the correct biomedical concept corresponding to 'caiv'. Answer using one of the provided options. | <Options>: A: activator of g-protein signaling 3 (aka g-protein-signaling modulator 1)
B: kiaa0514 (aka g protein-regulated inducer of neurite outgrowth 2)
C: hgpcr33 (aka g-protein coupled receptor family c group 6 member a)
D: kiaa0686 (aka g-protein coupled receptor 98)
E: dna repair protein b (dictyostelium discoideum) (aka tfiih basal transcription factor complex helicase repb subunit (dictyostelium discoideum))
F: g-protein coupled receptor family c group 5 member c (retinoic acid-induced gene 3 protein) (aka g-protein coupled receptor family c group 5 member c)
G: gprc5a (aka retinoic acid-induced protein 3)
H: sgn1 (aka cop9 signalosome complex subunit 1) (aka cop9 signalosome complex subunit 1)
I: tim22 (aka mitochondrial import inner membrane translocase subunit tim22)
J: gprc5d (aka g-protein coupled receptor family c group 5 member d)
K: None of the above. | K |
<Instruct>: Given the context 'Analysis of Myoc
Exons and the proximal promoter of the mouse Myoc gene were amplified from mouse genomic DNA using the following combinations of primers:
Exon 1: 5'-cttgcaggagaactttccagaa-3' and 5'-atctcgaaggagattgttatagg-3'
5'-gaccagctggagacccaaaccag-3' and 5'-gctcagatccactgacctaaa-3'
Exon 2: 5'-tgaagccatactttaccaaccat-3' and 5'-caaaagggagaagtctaacttc-3'
Exon 3: 5'-agtcaaggctcacagagctaa-3' and 5'-aagagtagctgctcaccgtgtacaag-3'
5'-agacattgacttagctgtggat-3' and 5'-cggaacttcaccttttctggc-3'
Promoter: 5'-taggagaagtctcattatactgc-3' and 5'-ttcactggaccagcataagga-3'
5'-tctgaggatgttcacaggtttat-3' and 5'-tcttctggaaagttctcctgca-3'
Samples underwent 30 cycles of amplification with Perkin-Elmer Taq polymerase in a PTC Thermal Cycler (MJ Research, MA)', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: cpn1/sigpep- (aka carboxypeptidase n catalytic chain, signal peptide removed form)
B: hirf6/iso:1 (aka interferon regulatory factor 6 isoform 1 (human))
C: il10/sigpep- (aka interleukin-10, signal peptide removed form)
D: transmembrane 4 l6 family member 5 (human) (htm4sf5) (aka transmembrane 4 l6 family member 5 (human))
E: cxcl16/full (aka c-x-c motif chemokine 16, full-length form)
F: cpne3/initmet- (aka copine-3, initiator methionine removed form)
G: spn/full (aka leukosialin, full-length form)
H: lag3/full (aka lymphocyte activation gene 3 protein, full-length form)
I: spom972h-abhd4 (aka cardiolipin-specific deacylase, mitochondrial (schizosaccharomyces pombe 972h-))
J: hgemin2/iso:h4 (aka gem-associated protein 2 isoform h4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Analysis of Myoc
Exons and the proximal promoter of the mouse Myoc gene were amplified from mouse genomic DNA using the following combinations of primers:
Exon 1: 5'-cttgcaggagaactttccagaa-3' and 5'-atctcgaaggagattgttatagg-3'
5'-gaccagctggagacccaaaccag-3' and 5'-gctcagatccactgacctaaa-3'
Exon 2: 5'-tgaagccatactttaccaaccat-3' and 5'-caaaagggagaagtctaacttc-3'
Exon 3: 5'-agtcaaggctcacagagctaa-3' and 5'-aagagtagctgctcaccgtgtacaag-3'
5'-agacattgacttagctgtggat-3' and 5'-cggaacttcaccttttctggc-3'
Promoter: 5'-taggagaagtctcattatactgc-3' and 5'-ttcactggaccagcataagga-3'
5'-tctgaggatgttcacaggtttat-3' and 5'-tcttctggaaagttctcctgca-3'
Samples underwent 30 cycles of amplification with Perkin-Elmer Taq polymerase in a PTC Thermal Cycler (MJ Research, MA)', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: cxcl16/full (aka c-x-c motif chemokine 16, full-length form)
B: cpox/full (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
C: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
D: carboxypeptidase n catalytic chain, signal peptide removed form (cpn1/sigpep-) (aka carboxypeptidase n catalytic chain, signal peptide removed form)
E: lag3/full (aka lymphocyte activation gene 3 protein, full-length form)
F: copine-3, initiator methionine removed form (cpne3/initmet-) (aka copine-3, initiator methionine removed form)
G: olfactory receptor 2b5 (aka olfactory receptor 2b6)
H: major prion protein, full-length form (prnp/full) (aka major prion protein, full-length form)
I: transmembrane 4 l6 family member 5 (human) (htm4sf5) (aka transmembrane 4 l6 family member 5 (human))
J: il10/sigpep- (aka interleukin-10, signal peptide removed form)
K: None of the above. | K |
<Instruct>: Given the context 'We also thank Jane Barker for the Car2 mice, Marianna Mertts for her help with analysis of Myoc alleles, and members of the John laboratory, Tatyana Golovkina, Edward Leiter and Timothy O'Brien for critical reading of the manuscript.', select the correct biomedical concept corresponding to 'myoc'. Answer using one of the provided options. | <Options>: A: nuclear body protein sp140-like protein isoform h4 (human) (hsp140l/iso:h4) (aka nuclear body protein sp140-like protein isoform h4 (human))
B: olfactory receptor 2b5 (aka olfactory receptor 2b6)
C: lag3/full (aka lymphocyte activation gene 3 protein, full-length form)
D: cpne3/initmet- (aka copine-3, initiator methionine removed form)
E: major prion protein, full-length form (prnp/full) (aka major prion protein, full-length form)
F: hgemin2/iso:h4 (aka gem-associated protein 2 isoform h4 (human))
G: cpn1/sigpep- (aka carboxypeptidase n catalytic chain, signal peptide removed form)
H: oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form (cpox/full) (aka oxygen-dependent coproporphyrinogen-iii oxidase, mitochondrial, full-length form)
I: lbp/sigpep- (aka lipopolysaccharide-binding protein, signal peptide removed form)
J: krueppel-like factor 11 isoform h2 (human) (hklf11/iso:h2) (aka krueppel-like factor 11 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues
Abstract
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci.', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided options. | <Options>: A: abc transporter g family member 18 (dictyostelium discoideum) (abc transporter abcg.18 (dictyostelium discoideum)) (aka abc transporter g family member 18 (dictyostelium discoideum))
B: protein af-10 (all1-fused gene from chromosome 10 protein) (aka protein af-10)
C: gtp-binding protein engb (escherichia coli k-12) (ec-engb) (aka gtp-binding protein engb (escherichia coli k-12))
D: znf346/iso:1 (aka zinc finger protein 346 isoform 1)
E: seven in absentia-like protein 8 (arabidopsis thaliana) (aka e3 ubiquitin-protein ligase sina-like 8 (arabidopsis thaliana))
F: yeats1 (aka protein enl)
G: von willebrand factor isoform 1 cleaved 2 (human) (von willebrand factor (human)) (aka von willebrand factor isoform 1 cleaved 2 (human))
H: psme2/iso:1 (aka proteasome activator complex subunit 2 isoform 1)
I: muskelin isoform 1 (mkln1/iso:1) (aka muskelin isoform 1)
J: at2g36680 (aka vacuolar protein-sorting-associated protein 37 homolog 2 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues
Abstract
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hdll4 (aka delta-like protein 4 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: znf228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues
Abstract
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Mutations in ATRX provided the first example of a human genetic disease associated with defects in such proteins.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cell stage of development.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: znf228 (aka e3 ubiquitin-protein ligase rnf114)
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cell stage of development.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The protein, Atrx, was ubiquitously expressed, and male embryos null for Atrx implanted and gastrulated normally but did not survive beyond 9.5 days postcoitus due to a defect in formation of the extraembryonic trophoblast, one of the first terminally differentiated lineages in the developing embryo.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The protein, Atrx, was ubiquitously expressed, and male embryos null for Atrx implanted and gastrulated normally but did not survive beyond 9.5 days postcoitus due to a defect in formation of the extraembryonic trophoblast, one of the first terminally differentiated lineages in the developing embryo.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Together these findings demonstrate an unexpected, specific, and essential role for Atrx in the development of the murine trophoblast and present an example of escape from imprinted X chromosome inactivation.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: znf313 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Synopsis
ATRX belongs to a class of proteins that may modify how DNA is packaged into chromatin, altering the accessibility of other proteins in the nucleus to DNA.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'In this way, ATRX is thought to influence gene expression.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
F: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: znf228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Mutations in the ATRX gene, which is located on the female sex chromosome (X), provided the first example of a human disease (ATR-X syndrome) associated with defects in such proteins.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: hdll4 (aka delta-like protein 4 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Currently, it is not understood how proteins like ATRX influence cell biology.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'To address this question, the authors deleted the version of the gene in mice, Atrx.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'In the placenta, female mice normally inactivate the X chromosome that they inherit from their fathers (Xp), so if females inherit from their mother an X chromosome (Xm) that bears the abnormal copy of Atrx (XmMUTXp), one would predict that, like affected males, they would fail to form a normal placenta.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
H: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'They showed, instead, that in such females the normal, paternally derived Atrx gene is active.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'It is usually associated with a mild form of α-thalassaemia, caused by reduced expression of structurally intact α-globin genes, and characterised by the presence of β-globin tetramers (haemoglobin H inclusion bodies) in peripheral red blood cells.', select the correct biomedical concept corresponding to 'β-globin'. Answer using one of the provided options. | <Options>: A: ryr2 (mouse) (aka ryanodine receptor 2 (mouse))
B: ciliary neurotrophic factor receptor alpha (aka ciliary neurotrophic factor receptor subunit alpha)
C: dor-1 (aka delta-type opioid receptor)
D: serpinb11 (aka serpin b11)
E: peptidase inhibitor 13 (aka serpin b13)
F: uncharacterized protein f22b7.3 (caenorhabditis elegans) (worm-f22b7.3) (aka uncharacterized protein f22b7.3 (caenorhabditis elegans))
G: pi-10 (aka serpin b10)
H: serpinb12 (aka serpin b12)
I: None of the above. | I |
<Instruct>: Given the context 'The ATR-X syndrome is caused by mutations in a gene (ATRX) that comprises 36 exons spanning 300 kb of genomic DNA at Chromosome Xq13.3', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: hdll4 (aka delta-like protein 4 (human))
F: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'As well as the full-length ATRX protein of ~280 kDa, which is encoded by a transcript of ~10 kb, we recently demonstrated that a truncated isoform called ATRXt (~200 kDa) is produced from a transcript of around 7 kb, which arises when intron 11 fails to be spliced from the primary transcript and an alternative intronic poly(A) signal is used [4].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: znf313 (aka e3 ubiquitin-protein ligase rnf114)
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The mouse homolog of the ATRX gene, Atrx, is also situated on the X chromosome, and also gives rise to full-length (Atrx, ~280 kDa) and truncated (Atrxt, ~200 kDa) isoforms [4,5].
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: hdll4 (aka delta-like protein 4 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The mouse homolog of the ATRX gene, Atrx, is also situated on the X chromosome, and also gives rise to full-length (Atrx, ~280 kDa) and truncated (Atrxt, ~200 kDa) isoforms [4,5].
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf313 (aka e3 ubiquitin-protein ligase rnf114)
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The mouse homolog of the ATRX gene, Atrx, is also situated on the X chromosome, and also gives rise to full-length (Atrx, ~280 kDa) and truncated (Atrxt, ~200 kDa) isoforms [4,5].
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: znf313 (aka e3 ubiquitin-protein ligase rnf114)
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Disease-causing missense mutations are clustered in two regions of the gene: a PHD-like zinc finger domain and a SNF2-like ATPase domain (Figure 1)', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided options. | <Options>: A: protein af-10 (all1-fused gene from chromosome 10 protein) (aka protein af-10)
B: znf346/iso:1 (aka zinc finger protein 346 isoform 1)
C: gtp-binding protein engb (escherichia coli k-12) (ec-engb) (aka gtp-binding protein engb (escherichia coli k-12))
D: yeats1 (aka protein enl)
E: f9g14.60 (aka e3 ubiquitin-protein ligase sgr9, amyloplastic (arabidopsis thaliana))
F: at2g36680 (aka vacuolar protein-sorting-associated protein 37 homolog 2 (arabidopsis thaliana))
G: trappc2l/iso:2 (aka trafficking protein particle complex subunit 2-like protein isoform 2)
H: psme2/iso:1 (aka proteasome activator complex subunit 2 isoform 1)
I: muskelin isoform 1 (mkln1/iso:1) (aka muskelin isoform 1)
J: abc transporter g family member 18 (dictyostelium discoideum) (abc transporter abcg.18 (dictyostelium discoideum)) (aka abc transporter g family member 18 (dictyostelium discoideum))
K: None of the above. | K |
<Instruct>: Given the context 'ATRX has been shown to remodel chromatin [8].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'It also interacts with HP1 at heterochromatin [9] and is recruited to promyelocytic leukemia nuclear bodies via an interaction with Daxx', select the correct biomedical concept corresponding to 'hp1'. Answer using one of the provided options. | <Options>: A: fancc-interacting protein (aka zinc finger and btb domain-containing protein 32)
B: zinc finger and btb domain-containing protein 41 (zbtb41) (aka zinc finger and btb domain-containing protein 41)
C: ankyrin repeat domain-containing protein 1 (human) (hankrd1) (aka ankyrin repeat domain-containing protein 1 (human))
D: ant3 (aka adp/atp translocase 3) (aka adp/atp translocase 3)
E: kaiso (aka transcriptional regulator kaiso)
F: nadc-1 (rat) (aka solute carrier family 13 member 2 (rat))
G: kiaa1538 (aka zinc finger and btb domain-containing protein 4)
H: csrp2bp (aka cysteine-rich protein 2-binding protein)
I: ns2 (influenza a virus (strain a/turkey/wisconsin/1/1966 h9n2)) (aka nuclear export protein (influenza a virus (strain a/turkey/wisconsin/1/1966 h9n2)))
J: hzmynd11/iso:h6 (aka zinc finger mynd domain-containing protein 11 isoform h6 (human))
K: None of the above. | K |
<Instruct>: Given the context 'It also interacts with HP1 at heterochromatin [9] and is recruited to promyelocytic leukemia nuclear bodies via an interaction with Daxx', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: mdlg2 (aka disks large homolog 2 (mouse))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: stk35 (aka serine/threonine-protein kinase 35)
D: htefm (aka transcription elongation factor, mitochondrial (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: znf228 (aka e3 ubiquitin-protein ligase rnf114)
G: worm-rcn2 (aka f08b6.3 (caenorhabditis elegans))
H: bsu22410 (aka aspartate 1-decarboxylase (bacillus subtilis subsp. subtilis str. 168))
I: trxr (aka thioredoxin reductase) (aka thioredoxin reductase)
J: ste20-like kinase mst1 (aka serine/threonine-protein kinase 4)
K: None of the above. | K |
<Instruct>: Given the context 'Furthermore, disruption of ATRX leads to diverse changes in DNA methylation [11].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'Nevertheless, the role ATRX plays in gene expression remains unclear.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'The consistent core of clinical and haematological features observed in ATR-X patients suggests that, like the SWI2/SNF2 chromatin-remodelling protein, ATRX probably regulates transcription of a discrete set of target genes.', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided options. | <Options>: A: psme2/iso:1 (aka proteasome activator complex subunit 2 isoform 1)
B: protein af-10 (all1-fused gene from chromosome 10 protein) (aka protein af-10)
C: muskelin isoform 1 (mkln1/iso:1) (aka muskelin isoform 1)
D: trappc2l/iso:2 (aka trafficking protein particle complex subunit 2-like protein isoform 2)
E: f9g14.60 (aka e3 ubiquitin-protein ligase sgr9, amyloplastic (arabidopsis thaliana))
F: abc transporter g family member 18 (dictyostelium discoideum) (abc transporter abcg.18 (dictyostelium discoideum)) (aka abc transporter g family member 18 (dictyostelium discoideum))
G: von willebrand factor (human) (aka von willebrand factor isoform 1 cleaved 2 (human))
H: ago1/iso:1 (aka protein argonaute-1 isoform 1)
I: yeats1 (aka protein enl)
J: at2g36680 (aka vacuolar protein-sorting-associated protein 37 homolog 2 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'The consistent core of clinical and haematological features observed in ATR-X patients suggests that, like the SWI2/SNF2 chromatin-remodelling protein, ATRX probably regulates transcription of a discrete set of target genes.', select the correct biomedical concept corresponding to 'swi2'. Answer using one of the provided options. | <Options>: A: thymidine phosphorylase (human) (htymp) (aka thymidine phosphorylase (human))
B: hcnot6/iso:1 (aka ccr4-not transcription complex subunit 6 isoform 1 (human))
C: abc transporter g family member 18 (dictyostelium discoideum) (abc transporter abcg.18 (dictyostelium discoideum)) (aka abc transporter g family member 18 (dictyostelium discoideum))
D: short stature homeobox protein isoform shoxa (human) (hshox/iso:shoxa) (aka short stature homeobox protein isoform shoxa (human))
E: aprt (caenorhabditis elegans) (aka adenine phosphoribosyltransferase (caenorhabditis elegans))
F: small g protein signaling modulator 3 (map (aka small g protein signaling modulator 3))
G: spom972h-rhp55 (aka dna repair protein rhp55 (schizosaccharomyces pombe 972h-))
H: spom972h-mug191 (aka meiotically up-regulated gene 191 protein (schizosaccharomyces pombe 972h-))
I: spac18b11.05 (aka gpi mannosyltransferase 2 (schizosaccharomyces pombe 972h-))
J: tim-14 (aka mitochondrial import inner membrane translocase subunit tim14 (caenorhabditis elegans))
K: None of the above. | K |
<Instruct>: Given the context 'The consistent core of clinical and haematological features observed in ATR-X patients suggests that, like the SWI2/SNF2 chromatin-remodelling protein, ATRX probably regulates transcription of a discrete set of target genes.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: znf228 (aka e3 ubiquitin-protein ligase rnf114)
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'However, although there are clearly others to be found, at present the α-globin genes remain the only confirmed targets for transcriptional regulation by ATRX.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Little is currently known about the precise role of the ATRX protein during mammalian development.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: hdll4 (aka delta-like protein 4 (human))
F: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To investigate the role of this protein during mouse development, we generated a conditionally deleted allele of the Atrx gene in mouse embryonic stem (ES) cells, and used these cells to examine the effect of ablating expression of the full-length Atrx protein in ES cells and in mouse embryos.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To investigate the role of this protein during mouse development, we generated a conditionally deleted allele of the Atrx gene in mouse embryonic stem (ES) cells, and used these cells to examine the effect of ablating expression of the full-length Atrx protein in ES cells and in mouse embryos.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Results
Generation of ES Cells Lacking Full-Length Atrx
Like the human gene, the mouse Atrx gene is also X-linked, such that a direct disruption of the single Atrx allele in male ES cells would immediately give rise to the null state.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: znf313 (aka e3 ubiquitin-protein ligase rnf114)
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: hdll4 (aka delta-like protein 4 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Results
Generation of ES Cells Lacking Full-Length Atrx
Like the human gene, the mouse Atrx gene is also X-linked, such that a direct disruption of the single Atrx allele in male ES cells would immediately give rise to the null state.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hdll4 (aka delta-like protein 4 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Results
Generation of ES Cells Lacking Full-Length Atrx
Like the human gene, the mouse Atrx gene is also X-linked, such that a direct disruption of the single Atrx allele in male ES cells would immediately give rise to the null state.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: znf313 (aka e3 ubiquitin-protein ligase rnf114)
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No targeted clones were recovered after attempted homologous recombination in male E14TG2a ES cells using two different vectors that removed exon 18 of the Atrx gene.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Exon 18 encodes the first of the seven motifs composing the conserved SNF2-like domain of Atrx (Figure 1); mutation of the corresponding motif of the yeast SNF2 protein has been shown to severely impair SWI/SNF-dependent gene expression [12].', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided options. | <Options>: A: at-at5g37900 (aka e3 ubiquitin-protein ligase sina-like 8 (arabidopsis thaliana))
B: abc transporter g family member 18 (dictyostelium discoideum) (abc transporter abcg.18 (dictyostelium discoideum)) (aka abc transporter g family member 18 (dictyostelium discoideum))
C: f9g14.60 (aka e3 ubiquitin-protein ligase sgr9, amyloplastic (arabidopsis thaliana))
D: yeats1 (aka protein enl)
E: trappc2l/iso:2 (aka trafficking protein particle complex subunit 2-like protein isoform 2)
F: ago1/iso:1 (aka protein argonaute-1 isoform 1)
G: at2g36680 (aka vacuolar protein-sorting-associated protein 37 homolog 2 (arabidopsis thaliana))
H: protein af-10 (all1-fused gene from chromosome 10 protein) (aka protein af-10)
I: psme2/iso:1 (aka proteasome activator complex subunit 2 isoform 1)
J: spac3c7.03c (aka dna repair protein rhp55 (schizosaccharomyces pombe 972h-))
K: None of the above. | K |
<Instruct>: Given the context 'Exon 18 encodes the first of the seven motifs composing the conserved SNF2-like domain of Atrx (Figure 1); mutation of the corresponding motif of the yeast SNF2 protein has been shown to severely impair SWI/SNF-dependent gene expression [12].', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided options. | <Options>: A: muskelin isoform 1 (mkln1/iso:1) (aka muskelin isoform 1)
B: yeats1 (aka protein enl)
C: spom972h-rhp55 (aka dna repair protein rhp55 (schizosaccharomyces pombe 972h-))
D: at2g36680 (aka vacuolar protein-sorting-associated protein 37 homolog 2 (arabidopsis thaliana))
E: znf346/iso:1 (aka zinc finger protein 346 isoform 1)
F: protein af-10 (all1-fused gene from chromosome 10 protein) (aka protein af-10)
G: von willebrand factor (human) (aka von willebrand factor isoform 1 cleaved 2 (human))
H: psme2/iso:1 (aka proteasome activator complex subunit 2 isoform 1)
I: protein argonaute-1 isoform 1 (ago1/iso:1) (aka protein argonaute-1 isoform 1)
J: gtp-binding protein engb (escherichia coli k-12) (ec-engb) (aka gtp-binding protein engb (escherichia coli k-12))
K: None of the above. | K |
<Instruct>: Given the context 'Exon 18 encodes the first of the seven motifs composing the conserved SNF2-like domain of Atrx (Figure 1); mutation of the corresponding motif of the yeast SNF2 protein has been shown to severely impair SWI/SNF-dependent gene expression [12].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The failure to recover targeted clones with these vectors suggested that Atrx may be important for normal ES cell growth and expansion and that direct targeting of the single locus may not be possible.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We therefore adopted a conditional strategy for targeting exon 18 (Figure 2) and recovered two clones in which exon 18 has been flanked by loxP recognition sites for the Cre recombinase (Atrxflox allele in Figure 2A) (Figure 2B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Northern and Western blot analyses (Figure 2D and 2E) confirmed that the Atrxflox clones continued to express both full-length Atrx protein and the truncated Atrxt isoform.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Northern and Western blot analyses (Figure 2D and 2E) confirmed that the Atrxflox clones continued to express both full-length Atrx protein and the truncated Atrxt isoform.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate the full deletion in ES cells, the Atrxflox clones (1/F12 and 1/G11) were transiently transfected with a Cre-recombinase expression plasmid (pCAGGS-Cre-IRESpuro), and subclones were recovered bearing an allele (AtrxΔ18Δneo in Figure 2A) in which both exon 18 and the neor cassette had been deleted by the Cre recombinase (resulting from the recombination event labelled “C” in the Atrxflox allele shown in Figure 2A) (Figure 2C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: znf228 (aka e3 ubiquitin-protein ligase rnf114)
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'To generate the full deletion in ES cells, the Atrxflox clones (1/F12 and 1/G11) were transiently transfected with a Cre-recombinase expression plasmid (pCAGGS-Cre-IRESpuro), and subclones were recovered bearing an allele (AtrxΔ18Δneo in Figure 2A) in which both exon 18 and the neor cassette had been deleted by the Cre recombinase (resulting from the recombination event labelled “C” in the Atrxflox allele shown in Figure 2A) (Figure 2C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate the full deletion in ES cells, the Atrxflox clones (1/F12 and 1/G11) were transiently transfected with a Cre-recombinase expression plasmid (pCAGGS-Cre-IRESpuro), and subclones were recovered bearing an allele (AtrxΔ18Δneo in Figure 2A) in which both exon 18 and the neor cassette had been deleted by the Cre recombinase (resulting from the recombination event labelled “C” in the Atrxflox allele shown in Figure 2A) (Figure 2C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Northern and Western blot analyses (Figure 2D and 2E) revealed that the full-length Atrx transcript and protein is completely abolished in the AtrxΔ18Δneo recombinant clones, suggesting that deletion of this region has a highly destabilising effect on the full-length transcript.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Northern and Western blot analyses (Figure 2D and 2E) revealed that the full-length Atrx transcript and protein is completely abolished in the AtrxΔ18Δneo recombinant clones, suggesting that deletion of this region has a highly destabilising effect on the full-length transcript.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Thus, a conditional knockout strategy allowed the isolation of ES cells that are null for full-length Atrx.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Perturbed Growth and Methylation Defects in Atrxnull ES Cells
Atrxnull ES cells could be maintained in culture but were generally slower growing than Atrx+ ES clones, and appeared to undergo higher rates of spontaneous differentiation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: znf228 (aka e3 ubiquitin-protein ligase rnf114)
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Perturbed Growth and Methylation Defects in Atrxnull ES Cells
Atrxnull ES cells could be maintained in culture but were generally slower growing than Atrx+ ES clones, and appeared to undergo higher rates of spontaneous differentiation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Perturbed Growth and Methylation Defects in Atrxnull ES Cells
Atrxnull ES cells could be maintained in culture but were generally slower growing than Atrx+ ES clones, and appeared to undergo higher rates of spontaneous differentiation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'We investigated directly the effect of Atrx on ES cell growth by comparing Atrx+ and Atrxnull ES cell clones in competition cultures.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
B: hdll4 (aka delta-like protein 4 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'We investigated directly the effect of Atrx on ES cell growth by comparing Atrx+ and Atrxnull ES cell clones in competition cultures.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'We investigated directly the effect of Atrx on ES cell growth by comparing Atrx+ and Atrxnull ES cell clones in competition cultures.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: znf313 (aka e3 ubiquitin-protein ligase rnf114)
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Equal numbers of Atrx+ (bearing either an AtrxWT or an Atrxflox allele) and Atrxnull (bearing an AtrxΔ18Δneo allele)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Equal numbers of Atrx+ (bearing either an AtrxWT or an Atrxflox allele) and Atrxnull (bearing an AtrxΔ18Δneo allele)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Equal numbers of Atrx+ (bearing either an AtrxWT or an Atrxflox allele) and Atrxnull (bearing an AtrxΔ18Δneo allele)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hdll4 (aka delta-like protein 4 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Equal numbers of Atrx+ (bearing either an AtrxWT or an Atrxflox allele) and Atrxnull (bearing an AtrxΔ18Δneo allele)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Equal numbers of Atrx+ (bearing either an AtrxWT or an Atrxflox allele) and Atrxnull (bearing an AtrxΔ18Δneo allele)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The clone containing the AtrxΔ18Δneo allele was rapidly outgrown by both AtrxWT ES cells and cells bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The clone containing the AtrxΔ18Δneo allele was rapidly outgrown by both AtrxWT ES cells and cells bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: hdll4 (aka delta-like protein 4 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The clone containing the AtrxΔ18Δneo allele was rapidly outgrown by both AtrxWT ES cells and cells bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: znf228 (aka e3 ubiquitin-protein ligase rnf114)
I: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'In a control competition experiment between different clones bearing functional Atrx alleles (AtrxWT and Atrxflox), both clones continued to be equally represented after 8 d of cocultivation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'In a control competition experiment between different clones bearing functional Atrx alleles (AtrxWT and Atrxflox), both clones continued to be equally represented after 8 d of cocultivation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'In a control competition experiment between different clones bearing functional Atrx alleles (AtrxWT and Atrxflox), both clones continued to be equally represented after 8 d of cocultivation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: znf228 (aka e3 ubiquitin-protein ligase rnf114)
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Thus, although Atrxnull ES cells could be recovered and maintained in culture by a conditional targeting approach, these cocultivation experiments suggested that the absence of Atrx does negatively impact upon normal ES cell growth.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: znf313 (aka e3 ubiquitin-protein ligase rnf114)
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Thus, although Atrxnull ES cells could be recovered and maintained in culture by a conditional targeting approach, these cocultivation experiments suggested that the absence of Atrx does negatively impact upon normal ES cell growth.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: hdll4 (aka delta-like protein 4 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'To investigate a possible cell-cycle defect in the absence of Atrx, we analysed the cell cycle distribution of bromodeoxyuridine (BrdU)-pulsed ES cells by flow cytometry (Figure S1A).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: hdll4 (aka delta-like protein 4 (human))
J: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (AtrxWT or Atrxflox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (AtrxWT or Atrxflox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: znf313 (aka e3 ubiquitin-protein ligase rnf114)
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
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