instruction stringlengths 142 1.78k | input stringlengths 321 1.59k | response stringclasses 11
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<Instruct>: Given the context 'Thus, in the extraembryonic compartment of AtrxWT/null carrier females, normal imprinted X-inactivation would be expected to result in silencing of the paternally derived AtrxWT allele, leaving only the Atrxnull allele on the active maternal X (Xm) and thereby render the extraembryonic ti... | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcrip... | K |
<Instruct>: Given the context 'Thus, in the extraembryonic compartment of AtrxWT/null carrier females, normal imprinted X-inactivation would be expected to result in silencing of the paternally derived AtrxWT allele, leaving only the Atrxnull allele on the active maternal X (Xm) and thereby render the extraembryonic ti... | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: znf313 (aka e3 ub... | K |
<Instruct>: Given the context 'Thus, in the extraembryonic compartment of AtrxWT/null carrier females, normal imprinted X-inactivation would be expected to result in silencing of the paternally derived AtrxWT allele, leaving only the Atrxnull allele on the active maternal X (Xm) and thereby render the extraembryonic ti... | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytoc... | K |
<Instruct>: Given the context 'Thus, in the extraembryonic compartment of AtrxWT/null carrier females, normal imprinted X-inactivation would be expected to result in silencing of the paternally derived AtrxWT allele, leaving only the Atrxnull allele on the active maternal X (Xm) and thereby render the extraembryonic ti... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: cytochrome p450 ... | K |
<Instruct>: Given the context 'However, the absence of Atrx in the extraembryonic compartment is lethal in Atrxnull/Y males.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: yth domain-containing f... | K |
<Instruct>: Given the context 'However, the absence of Atrx in the extraembryonic compartment is lethal in Atrxnull/Y males.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: transcription factor e2f5 isoform h2 (h... | K |
<Instruct>: Given the context 'This suggested the possibility of an escape from imprinted inactivation of the paternally derived AtrxWT allele in the extraembryonic compartment of a proportion of carrier female embryos.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided ... | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: rnf... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hythdf1/iso:1 (aka yth doma... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: hythdf1 (ak... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: znf313 (aka e3 ubiquitin-protein ligase rnf114)
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hythdf1 (aka... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: transcription factor e2f5 isoform h2 (h... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka ... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
B: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
C: immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50) (staphylococcal protein a (staphylococcus aureus subsp. aure... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
B: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
C: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
D: trim72/iso:1 (aka tripartite motif-containing protein 72 isoform 1)
E: cell division cycle protein 20 phosph... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
B: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
C: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
D: penicillinase repressor (staphylococcus epidermidis atcc 12228)... | K |
<Instruct>: Given the context 'To investigate further, we crossed homozygous Atrxflox/flox females and homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+), which would be expected to yield only Atrxnull males (Atrxnull/Y;GATA1-cre+/β) and carrier females (AtrxWT/null;GATA1-cre+/β).', select the correct biomed... | <Options>: A: bub3/phos:1 (aka mitotic checkpoint protein bub3 phosphorylated 1)
B: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
C: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
D: hbub1b/phos:4 (aka m... | K |
<Instruct>: Given the context 'In these carrier females, the AtrxWT allele is paternally inherited.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: hel... | K |
<Instruct>: Given the context 'Embryos were dissected in their deciduas at 7.5 dpc, and paraffin sections were stained with anti-ATRX antibody, along with sections from a wild-type 7.5 dpc embryo for comparison (Figure 8).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: znf313 (aka e3 ubiquitin-protein ligas... | K |
<Instruct>: Given the context 'As described above, Atrx expression was detected in every cell in the epiblast (embryo proper) region of wild-type 7.5 dpc embryos (Figure 8B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: ring finger protein 114 (aka e3 ubiquitin-protein ... | K |
<Instruct>: Given the context 'In contrast, the epiblast region of carrier female embryos was composed of a mosaic of small clusters of Atrx-positive cells (in which the Atrxnull allele on Xm had been inactivated) and Atrx-negative cells (in which the AtrxWT allele on Xp had been inactivated), indicating that the Atrx ... | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal pr... | K |
<Instruct>: Given the context 'In contrast, the epiblast region of carrier female embryos was composed of a mosaic of small clusters of Atrx-positive cells (in which the Atrxnull allele on Xm had been inactivated) and Atrx-negative cells (in which the AtrxWT allele on Xp had been inactivated), indicating that the Atrx ... | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-contai... | K |
<Instruct>: Given the context 'In contrast, the epiblast region of carrier female embryos was composed of a mosaic of small clusters of Atrx-positive cells (in which the Atrxnull allele on Xm had been inactivated) and Atrx-negative cells (in which the AtrxWT allele on Xp had been inactivated), indicating that the Atrx ... | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
D: hmbnl1/iso:h7 (aka... | K |
<Instruct>: Given the context 'In contrast, the epiblast region of carrier female embryos was composed of a mosaic of small clusters of Atrx-positive cells (in which the Atrxnull allele on Xm had been inactivated) and Atrx-negative cells (in which the AtrxWT allele on Xp had been inactivated), indicating that the Atrx ... | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: e3 ub... | K |
<Instruct>: Given the context 'In contrast, the epiblast region of carrier female embryos was composed of a mosaic of small clusters of Atrx-positive cells (in which the Atrxnull allele on Xm had been inactivated) and Atrx-negative cells (in which the AtrxWT allele on Xp had been inactivated), indicating that the Atrx ... | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: transcrip... | K |
<Instruct>: Given the context 'Remarkably, clear Atrx expression could also be detected in the extraembryonic tissues of carrier females, as shown in the extraembryonic-derived chorionic ectoderm (Figure 8C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: delt... | K |
<Instruct>: Given the context 'Atrx expression could be detected in almost all cells of the chorionic ectoderm.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (... | K |
<Instruct>: Given the context 'Atrx expression was also clearly detected in other extraembryonic structures, including TGCs (unpublished data).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 ... | K |
<Instruct>: Given the context 'Escape from silencing of an Xp-inherited AtrxWT allele was also observed in the chorionic ectoderm of carrier females at 8.5 dpc (Figure S4).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: hdll4 (aka delta-like protein 4 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: helicase with zinc finger do... | K |
<Instruct>: Given the context 'Thus, although random X-inactivation occurs normally within the epiblast, the AtrxWT allele (inherited on the Xp chromosome) escaped the normal imprinted X-inactivation in the extraembryonic compartment of some carrier females.
', select the correct biomedical concept corresponding to 'a... | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: y... | K |
<Instruct>: Given the context 'Discussion
We investigated the role of the Atrx protein in mouse development.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: hythdf1 (a... | K |
<Instruct>: Given the context 'By using a conditional knockout approach, we ablated the full-length Atrx protein first in ES cells and embryoid bodies, and then in developing mouse embryos.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: transcripti... | K |
<Instruct>: Given the context 'Atrx in ES Cells
Atrxnull ES cells could not be recovered by direct targeting and were eventually generated by adopting a conditional targeting approach.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hmbnl1/iso:h7 ... | K |
<Instruct>: Given the context 'Atrx in ES Cells
Atrxnull ES cells could not be recovered by direct targeting and were eventually generated by adopting a conditional targeting approach.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hythdf1/iso:1 (aka yth domain-containing ... | K |
<Instruct>: Given the context 'This is consistent with our observation that Atrx is highly expressed in ES cells, and that the absence of full-length Atrx imparts a growth disadvantage relative to cells bearing a functional Atrx allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one o... | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isofo... | K |
<Instruct>: Given the context 'This is consistent with our observation that Atrx is highly expressed in ES cells, and that the absence of full-length Atrx imparts a growth disadvantage relative to cells bearing a functional Atrx allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one o... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human... | K |
<Instruct>: Given the context 'This is consistent with our observation that Atrx is highly expressed in ES cells, and that the absence of full-length Atrx imparts a growth disadvantage relative to cells bearing a functional Atrx allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one o... | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (a... | K |
<Instruct>: Given the context 'At present, the cause of the proliferative delay in Atrxnull ES cells is not known.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: hdll4 (aka delta-like protein 4 (human))
F: yth domain-containing ... | K |
<Instruct>: Given the context 'Interestingly, we demonstrated that apoptosis is not significantly up-regulated in ES cells lacking Atrx and is only mildly elevated in Atrxnull 7.5 dpc mouse embryos.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: trans... | K |
<Instruct>: Given the context 'Interestingly, we demonstrated that apoptosis is not significantly up-regulated in ES cells lacking Atrx and is only mildly elevated in Atrxnull 7.5 dpc mouse embryos.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hmbnl1/iso:h7 ... | K |
<Instruct>: Given the context 'In contrast, it was recently shown that the loss of Atrx markedly increased the apoptotic population in the differentiating cells of the embryonic cortex and postnatal hippocampus, when Atrx expression was ablated in the developing mouse forebrain using the Atrxflox allele described here ... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: helicase with ... | K |
<Instruct>: Given the context 'In contrast, it was recently shown that the loss of Atrx markedly increased the apoptotic population in the differentiating cells of the embryonic cortex and postnatal hippocampus, when Atrx expression was ablated in the developing mouse forebrain using the Atrxflox allele described here ... | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (ak... | K |
<Instruct>: Given the context 'In contrast, it was recently shown that the loss of Atrx markedly increased the apoptotic population in the differentiating cells of the embryonic cortex and postnatal hippocampus, when Atrx expression was ablated in the developing mouse forebrain using the Atrxflox allele described here ... | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 ... | K |
<Instruct>: Given the context 'The human ATRX protein has been shown to associate in a complex with Daxx', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 is... | K |
<Instruct>: Given the context 'The human ATRX protein has been shown to associate in a complex with Daxx', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: stk35 (aka serine/threonine-protein kinase 35)
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: worm-rcn2 (aka f08b6.3 (caenorhabditis elegans))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: dlgh2 (aka disks large homolog ... | K |
<Instruct>: Given the context 'It is possible that disruption of the mouse Atrx-Daxx complex (by ablation of the Atrx protein) could have triggered a universal proapoptotic response.', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: bsu22410 (aka aspartate 1-decarboxylase (bacillus subtilis subsp. subtilis str. 168))
C: shc-transforming protein homolog 1 (caenorhabditis elegans) (src homology 2 domain adapter homolog 1 (caenorhabditis elegans)) (aka shc-transforming protein homolog 1... | K |
<Instruct>: Given the context 'It is possible that disruption of the mouse Atrx-Daxx complex (by ablation of the Atrx protein) could have triggered a universal proapoptotic response.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p45... | K |
<Instruct>: Given the context 'It is possible that disruption of the mouse Atrx-Daxx complex (by ablation of the Atrx protein) could have triggered a universal proapoptotic response.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: znf313 (aka e3 ubiquitin-protein ligase rnf114)
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h... | K |
<Instruct>: Given the context 'However, our observations in ES cells demonstrate that the induction of apoptosis is not an automatic response triggered by the removal of Atrx in all cell types, and suggest that the inappropriate apoptosis observed in the Atrx-mutant forebrain may reflect a requirement for Atrx during t... | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome ... | K |
<Instruct>: Given the context 'However, our observations in ES cells demonstrate that the induction of apoptosis is not an automatic response triggered by the removal of Atrx in all cell types, and suggest that the inappropriate apoptosis observed in the Atrx-mutant forebrain may reflect a requirement for Atrx during t... | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda... | K |
<Instruct>: Given the context 'However, our observations in ES cells demonstrate that the induction of apoptosis is not an automatic response triggered by the removal of Atrx in all cell types, and suggest that the inappropriate apoptosis observed in the Atrx-mutant forebrain may reflect a requirement for Atrx during t... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: hdll4 (aka delta-like protein 4 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: f9n12.12 (aka tetraspanin-10... | K |
<Instruct>: Given the context 'An Unexpected Role for Atrx in Development of the Mouse Trophoblast
We show that Atrxnull male mice are not viable and embryos die by around 9.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger prote... | K |
<Instruct>: Given the context 'An Unexpected Role for Atrx in Development of the Mouse Trophoblast
We show that Atrxnull male mice are not viable and embryos die by around 9.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: znf313 (aka e3 ubiquitin-protein ligase rnf114)
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-act... | K |
<Instruct>: Given the context 'Before death, Atrxnull embryos exhibit a markedly reduced mitotic index, suggesting a proliferative defect.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finge... | K |
<Instruct>: Given the context 'Although the embryonic compartment of the conceptus appears initially normal, by 7.5 dpc Atrxnull embryos display abnormalities in development of the trophoblast, including a depletion in the population of TGCs surrounding the conceptus and a reduction in the size of the ectoplacental con... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
D: helicase with zinc f... | K |
<Instruct>: Given the context 'Since Atrxnull embryos appear to implant normally, lethality is likely to arise due to a failure of TGC function later during development.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isofor... | K |
<Instruct>: Given the context 'Embryonic lethality in mice in the absence of Atrx was a surprising finding, as there had been no suggestion of foetal loss in the human ATR-X syndrome.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: helicase with zinc finger doma... | K |
<Instruct>: Given the context 'It is possible that the role of Atrx in the trophoblast is specific to mice and that ATRX has no role or is redundant in the human trophoblast.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hythdf1/iso:1 (aka yth domain-containing fami... | K |
<Instruct>: Given the context 'It is possible that the role of Atrx in the trophoblast is specific to mice and that ATRX has no role or is redundant in the human trophoblast.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human)... | K |
<Instruct>: Given the context 'An alternative explanation for the unexpectedly severe phenotype we observed in mice is that the AtrxΞ18Ξneo deletion generated by Cre recombination completely ablates full-length Atrx protein (Figure 2E).', select the correct biomedical concept corresponding to 'atrx'. Answer using one o... | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-... | K |
<Instruct>: Given the context 'An alternative explanation for the unexpectedly severe phenotype we observed in mice is that the AtrxΞ18Ξneo deletion generated by Cre recombination completely ablates full-length Atrx protein (Figure 2E).', select the correct biomedical concept corresponding to 'atrx'. Answer using one o... | <Options>: A: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like p... | K |
<Instruct>: Given the context 'Some full-length ATRX protein is detected in cases predicted to have truncating mutations (RJG, unpublished data), and residual ATPase activity in ATRX immunoprecipitates can be detected in Epstein-Barr virus-transformed lymphocytes of all human patients analysed to date (A. Argentaro and... | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: hythdf1/iso:1 (aka yth domain-containing family ... | K |
<Instruct>: Given the context 'Some full-length ATRX protein is detected in cases predicted to have truncating mutations (RJG, unpublished data), and residual ATPase activity in ATRX immunoprecipitates can be detected in Epstein-Barr virus-transformed lymphocytes of all human patients analysed to date (A. Argentaro and... | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana... | K |
<Instruct>: Given the context 'The failure to observe a truly null ATRX allele among human patients strongly suggests that, as in the mouse, the complete absence of ATRX protein is incompatible with human fetal survival.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided... | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor ... | K |
<Instruct>: Given the context 'The failure to observe a truly null ATRX allele among human patients strongly suggests that, as in the mouse, the complete absence of ATRX protein is incompatible with human fetal survival.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided... | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: yth domain-containing family protein 1 isoform h2 (hu... | K |
<Instruct>: Given the context 'While this study has revealed an unexpected role for Atrx in the murine trophectoderm, as a result of the early lethality observed in Atrxnull embryos it is not possible to rule out other roles for Atrx at later developmental stages in tissues of the embryo proper.', select the correct bi... | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a... | K |
<Instruct>: Given the context 'While this study has revealed an unexpected role for Atrx in the murine trophectoderm, as a result of the early lethality observed in Atrxnull embryos it is not possible to rule out other roles for Atrx at later developmental stages in tissues of the embryo proper.', select the correct bi... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
D: yth domain-containing family protei... | K |
<Instruct>: Given the context 'While this study has revealed an unexpected role for Atrx in the murine trophectoderm, as a result of the early lethality observed in Atrxnull embryos it is not possible to rule out other roles for Atrx at later developmental stages in tissues of the embryo proper.', select the correct bi... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: yth domain-containing family protein 1 isoform h2 (hu... | K |
<Instruct>: Given the context 'Indeed, we show that Atrx is highly expressed throughout the entire developing embryo at 7.5 dpc (Figure 5B), and it is likely that Atrx function will turn out to be important for other differentiating tissues.', select the correct biomedical concept corresponding to 'atrx'. Answer using ... | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: cytoc... | K |
<Instruct>: Given the context 'Indeed, we show that Atrx is highly expressed throughout the entire developing embryo at 7.5 dpc (Figure 5B), and it is likely that Atrx function will turn out to be important for other differentiating tissues.', select the correct biomedical concept corresponding to 'atrx'. Answer using ... | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: transcription ... | K |
<Instruct>: Given the context 'Tetraploid aggregation experiments (in which mutant embryos are rescued with wild-type extraembryonic tissues) might shed more light on the role of Atrx during later mouse development, but these issues can be more subtly dissected by combining the conditional Atrxflox allele that we have ... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: f9n12.12 (aka ... | K |
<Instruct>: Given the context 'Tetraploid aggregation experiments (in which mutant embryos are rescued with wild-type extraembryonic tissues) might shed more light on the role of Atrx during later mouse development, but these issues can be more subtly dissected by combining the conditional Atrxflox allele that we have ... | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: heli... | K |
<Instruct>: Given the context 'As mentioned above, this approach has already revealed a critical role for Atrx during neuronal differentiation in adult mice [20].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: helicase with zinc finger domain 2 (human) (... | K |
<Instruct>: Given the context 'Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a... | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth dom... | K |
<Instruct>: Given the context 'Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a... | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like pro... | K |
<Instruct>: Given the context 'Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a... | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human... | K |
<Instruct>: Given the context 'Further evidence that Atrx is also required at later stages of mouse development is provided by the observed dramatic skewing against Atrx-negative cells in some somatic tissues of carrier female mice, whose tissues initially comprise a mosaic of Atrx-positive and Atrx-negative cells as a... | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 28... | K |
<Instruct>: Given the context 'Atrx joins an expanding list of mouse genes for which targeted disruption results in peri-implantation lethality as a result of trophoblast or placental abnormalities (reviewed in [25]).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided opti... | <Options>: A: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3... | K |
<Instruct>: Given the context 'Comparison with other phenotypes might provide some insight into the role of Atrx in trophoblast development.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (... | K |
<Instruct>: Given the context 'Atrx-mutant embryos progress further than embryos nullizygous for factors involved in the initial specification of trophoblast stem cells (such as Cdx2) or in stem cell maintenance and proliferation (such as Eomes).', select the correct biomedical concept corresponding to 'atrx'. Answer u... | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D:... | K |
<Instruct>: Given the context 'Atrx-mutant embryos progress further than embryos nullizygous for factors involved in the initial specification of trophoblast stem cells (such as Cdx2) or in stem cell maintenance and proliferation (such as Eomes).', select the correct biomedical concept corresponding to 'cdx2'. Answer u... | <Options>: A: transcription factor sl1 (aka tata box-binding protein-associated factor rna polymerase i subunit a)
B: corneodesmosin (human) (hcdsn) (aka corneodesmosin (human))
C: hspa17 (aka sperm surface protein sp17 (human))
D: mcbx1/iso:1 (aka chromobox protein homolog 1 isoform 1 (mouse))
E: hsphar (aka protein s... | K |
<Instruct>: Given the context 'Atrx-mutant embryos progress further than embryos nullizygous for factors involved in the initial specification of trophoblast stem cells (such as Cdx2) or in stem cell maintenance and proliferation (such as Eomes).', select the correct biomedical concept corresponding to 'eomes'. Answer ... | <Options>: A: spom972h-vps18 (aka vacuolar membrane protein pep3 (schizosaccharomyces pombe 972h-))
B: rtimm44 (aka mitochondrial import inner membrane translocase subunit tim44 (rat))
C: ornithine aminotransferase, mitochondrial proteolytic cleavage product (oat/clvprd) (aka ornithine aminotransferase, mitochondrial p... | K |
<Instruct>: Given the context 'Cdx2-mutant embryos fail to implant and die between 3.5 and 5.5 dpc [26], while Eomes-mutant blastocysts implant into the uterus, but arrest soon after implantation without forming organised embryonic or extraembryonic structures', select the correct biomedical concept corresponding to 'c... | <Options>: A: rna polymerase i-specific tbp-associated factor 63 kda (aka tata box-binding protein-associated factor rna polymerase i subunit b)
B: hklhl5/iso:h5 (aka kelch-like protein 5 isoform h5 (human))
C: corneodesmosin (human) (hcdsn) (aka corneodesmosin (human))
D: kelch-like protein 5 isoform h6 (human) (hklhl... | K |
<Instruct>: Given the context 'Cdx2-mutant embryos fail to implant and die between 3.5 and 5.5 dpc [26], while Eomes-mutant blastocysts implant into the uterus, but arrest soon after implantation without forming organised embryonic or extraembryonic structures', select the correct biomedical concept corresponding to 'e... | <Options>: A: mitochondrial import inner membrane translocase subunit tim44 (rat) (rtimm44) (aka mitochondrial import inner membrane translocase subunit tim44 (rat))
B: ornithine aminotransferase, mitochondrial proteolytic cleavage product (oat/clvprd) (aka ornithine aminotransferase, mitochondrial proteolytic cleavage... | K |
<Instruct>: Given the context 'In contrast, Atrx-mutant embryos implant successfully and establish organised embryonic structures by 7.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: f9n12... | K |
<Instruct>: Given the context 'The Atrx-mutant phenotype closely resembles that observed in mice nullizygous for the basic helix-loop-helix transcription factor Hand1.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: hythdf1/iso:1 (aka yth doma... | K |
<Instruct>: Given the context 'The Atrx-mutant phenotype closely resembles that observed in mice nullizygous for the basic helix-loop-helix transcription factor Hand1.', select the correct biomedical concept corresponding to 'hand1'. Answer using one of the provided options. | <Options>: A: utp--glucose-1-phosphate uridylyltransferase (ugp1 (aka utp--glucose-1-phosphate uridylyltransferase))
B: at5g14130 (aka peroxidase 55 (arabidopsis thaliana))
C: udp-glucuronosyltransferase 1a1 (aka udp-glucuronosyltransferase 1-1)
D: desert hedgehog protein isoform 1 (dhh/iso:1) (aka desert hedgehog prot... | K |
<Instruct>: Given the context 'Hand1-mutant conceptuses arrest at around 7.5 dpc and display a normal embryonic compartment, but, like Atrx-mutant embryos, ablation of Hand1 causes a reduction in the size of the ectoplacental cone and density of TGCs [28].', select the correct biomedical concept corresponding to 'hand1... | <Options>: A: importin subunit alpha-4, initiator methionine removed form (kpna4/initmet-) (aka importin subunit alpha-4, initiator methionine removed form)
B: desert hedgehog protein isoform 1 (dhh/iso:1) (aka desert hedgehog protein isoform 1)
C: udpgdh (aka udp-glucose 6-dehydrogenase)
D: at5g14130 (aka peroxidase 5... | K |
<Instruct>: Given the context 'Hand1-mutant conceptuses arrest at around 7.5 dpc and display a normal embryonic compartment, but, like Atrx-mutant embryos, ablation of Hand1 causes a reduction in the size of the ectoplacental cone and density of TGCs [28].', select the correct biomedical concept corresponding to 'atrx'... | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
D: hmbnl1/i... | K |
<Instruct>: Given the context 'Hand1-mutant conceptuses arrest at around 7.5 dpc and display a normal embryonic compartment, but, like Atrx-mutant embryos, ablation of Hand1 causes a reduction in the size of the ectoplacental cone and density of TGCs [28].', select the correct biomedical concept corresponding to 'hand1... | <Options>: A: hsamd5 (aka sterile alpha motif domain-containing protein 5 (human))
B: importin subunit alpha-4, initiator methionine removed form (kpna4/initmet-) (aka importin subunit alpha-4, initiator methionine removed form)
C: gtpase kras, initiator methionine removed form (kras/initmet-) (aka gtpase kras, initiat... | K |
<Instruct>: Given the context 'As with Atrx mutants, only arrested or resorbed Hand1-mutant conceptuses were recovered after 8.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115... | K |
<Instruct>: Given the context 'As with Atrx mutants, only arrested or resorbed Hand1-mutant conceptuses were recovered after 8.5 dpc.', select the correct biomedical concept corresponding to 'hand1'. Answer using one of the provided options. | <Options>: A: fgf16/iso:1 (aka fibroblast growth factor 16 isoform 1)
B: atp21a (arabidopsis thaliana) (aka peroxidase 35 (arabidopsis thaliana))
C: importin subunit alpha-6, initiator methionine removed form (kpna5/initmet-) (aka importin subunit alpha-6, initiator methionine removed form)
D: hsamd5 (aka sterile alpha... | K |
<Instruct>: Given the context 'Also like Atrx, disruption of Hand1 specifically affects secondary giant cell formation, and primary trophoblast outgrowths from blastocysts appeared normal.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (... | K |
<Instruct>: Given the context 'Also like Atrx, disruption of Hand1 specifically affects secondary giant cell formation, and primary trophoblast outgrowths from blastocysts appeared normal.', select the correct biomedical concept corresponding to 'hand1'. Answer using one of the provided options. | <Options>: A: kpna5/initmet- (aka importin subunit alpha-6, initiator methionine removed form)
B: ugp2 (aka utp--glucose-1-phosphate uridylyltransferase) (aka utp--glucose-1-phosphate uridylyltransferase)
C: leukocyte-specific transcript 1 protein isoform lst1/n (human) (aka leukocyte-specific transcript 1 protein isof... | K |
<Instruct>: Given the context 'Hand1 is required for terminal differentiation of secondary TGCs, and in its absence trophoblast cells arrest at a precursor stage in the ectoplacental cone', select the correct biomedical concept corresponding to 'hand1'. Answer using one of the provided options. | <Options>: A: udpgdh (aka udp-glucose 6-dehydrogenase)
B: fgf16/iso:1 (aka fibroblast growth factor 16 isoform 1)
C: gtpase kras, initiator methionine removed form (kras/initmet-) (aka gtpase kras, initiator methionine removed form)
D: hsamd5 (aka sterile alpha motif domain-containing protein 5 (human))
E: importin sub... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: gtpase kras, initiator methionine removed form (kras/initmet-) (aka gtpase kras, initiator methionine removed form)
B: ugt1 (aka udp-glucuronosyltransferase 1-1) (aka udp-glucuronosyltransferase 1-1)
C: krt10/initmet- (aka keratin, type i cytoskeletal 10, initiator methionine removed form)
D: importin sub... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: transcription factor e... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: znf313 (aka e3 ubiquitin-protein ligase rnf114)
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D:... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferato... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: krt10/initmet- (aka keratin, type i cytoskeletal 10, initiator methionine removed form)
B: utp--glucose-1-phosphate uridylyltransferase (ugp1 (aka utp--glucose-1-phosphate uridylyltransferase))
C: desert hedgehog protein isoform 1 (dhh/iso:1) (aka desert hedgehog protein isoform 1)
D: udpgdh (aka udp-gluc... | K |
<Instruct>: Given the context 'Given the similarity of the Atrx- and Hand1-mutant phenotypes and the likelihood that Atrx acts as a transcriptional regulator by modifying chromatin structure, it will be of interest to determine whether Atrx is itself a regulator of Hand1 expression, or alternatively whether it acts as ... | <Options>: A: fgf16/iso:1 (aka fibroblast growth factor 16 isoform 1)
B: udpgdh (aka udp-glucose 6-dehydrogenase)
C: leukocyte-specific transcript 1 protein isoform lst1/n (human) (aka leukocyte-specific transcript 1 protein isoform h9 (human))
D: desert hedgehog protein isoform 1 (dhh/iso:1) (aka desert hedgehog prote... | K |
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