instruction stringlengths 142 1.78k | input stringlengths 321 1.59k | response stringclasses 11 values |
|---|---|---|
<Instruct>: Given the context 'Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (AtrxWT or Atrxflox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Surprisingly, both Atrxnull ES cell clones exhibited a cell cycle profile that was indistinguishable from ES cells bearing a functional Atrx allele (AtrxWT or Atrxflox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: hdll4 (aka delta-like protein 4 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We also specifically quantitated the mitotic index within each population by flow cytometry after staining ES cells for phosphorylated (Ser10) histone H3, a specific marker of mitosis (Figure S1B)', select the correct biomedical concept corresponding to 'histone h3'. Answer using one of the provided options. | <Options>: A: kelch repeat and btb domain-containing protein 12 isoform h2 (human) (hkbtbd12/iso:h2) (aka kelch repeat and btb domain-containing protein 12 isoform h2 (human))
B: worm-c50c3.1 (aka uncharacterized protein c50c3.1 (caenorhabditis elegans))
C: yjefn3 (aka yjef n-terminal domain-containing protein 3)
D: lymphocyte expansion molecule isoform h1 (human) (hlexm/iso:h1) (aka lymphocyte expansion molecule isoform h1 (human))
E: ylr063w (aka 25s rrna (uridine(2843)-n(3))-methyltransferase (yeast))
F: membrane protein fam174b (human) (hfam174b) (aka membrane protein fam174b (human))
G: hanxa2r (aka annexin-2 receptor (human))
H: ciliary localization protein 1 (caenorhabditis elegans) (aka inositol polyphosphate 5-phosphatase (caenorhabditis elegans))
I: hlexm (aka lymphocyte expansion molecule (human))
J: uncharacterized calcium-binding protein c50c3.5 (caenorhabditis elegans) (worm-c50c3.5) (aka uncharacterized calcium-binding protein c50c3.5 (caenorhabditis elegans))
K: None of the above. | K |
<Instruct>: Given the context 'Consistent with the normal cell-cycle profile observed above, there was no depletion in the size of the mitotic population in the Atrxnull ES clones, despite their slow growth.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Finally, we investigated whether the growth defect in the Atrxnull ES cells was due to an up-regulation of apoptosis by staining cells with Annexin V (Figure S2) and found that the proportion of apoptotic cells was not significantly affected by the absence of full-length Atrx.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: hdll4 (aka delta-like protein 4 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'Finally, we investigated whether the growth defect in the Atrxnull ES cells was due to an up-regulation of apoptosis by staining cells with Annexin V (Figure S2) and found that the proportion of apoptotic cells was not significantly affected by the absence of full-length Atrx.', select the correct biomedical concept corresponding to 'annexin v'. Answer using one of the provided options. | <Options>: A: calcium-dependent secretion activator 2 (calcium-dependent activator protein for secretion 2) (aka calcium-dependent secretion activator 2)
B: calretinin (29 kda calbindin) (aka calretinin)
C: caps1 (aka calcium-dependent secretion activator 1)
D: cab27 (aka calbindin)
E: cad protein (cad (aka cad protein))
F: rpsd (xancp) (aka 30s ribosomal protein s4 (xanthomonas campestris pv. campestris str. atcc 33913))
G: e3 ubiquitin-protein ligase mdm2 (human) (hmdm2) (aka e3 ubiquitin-protein ligase mdm2 (human))
H: e3 ubiquitin-protein ligase mdm2 isoform hmdm2-a (human) (hmdm2/iso:hmdm2-a) (aka e3 ubiquitin-protein ligase mdm2 isoform hmdm2-a (human))
I: cadm3 (aka cell adhesion molecule 3)
J: necl-3 (aka cell adhesion molecule 2)
K: None of the above. | K |
<Instruct>: Given the context 'Finally, we investigated whether the growth defect in the Atrxnull ES cells was due to an up-regulation of apoptosis by staining cells with Annexin V (Figure S2) and found that the proportion of apoptotic cells was not significantly affected by the absence of full-length Atrx.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Thus, the growth defect observed in ES cells lacking Atrx is not due to a specific cell cycle block or significant induction of cell death.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'While the cause of the proliferative delay is not yet clear, since Atrxnull ES cells appear to undergo higher rates of spontaneous differentiation (unpublished data), it seems likely that the observed growth defect reflects the spontaneous transition from fast-cycling, undifferentiated ES cells into more slowly cycling, differentiated cell types in these cultures.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: hdll4 (aka delta-like protein 4 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'It has been shown that disease-causing mutations in the human ATRX gene give rise to changes in the normal pattern of DNA methylation at several repetitive sequences within the human genome [11].', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hdll4 (aka delta-like protein 4 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (AtrxWT or Atrxflox) (Figure 3B and 3C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: znf313 (aka e3 ubiquitin-protein ligase rnf114)
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: hdll4 (aka delta-like protein 4 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (AtrxWT or Atrxflox) (Figure 3B and 3C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: hdll4 (aka delta-like protein 4 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (AtrxWT or Atrxflox) (Figure 3B and 3C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: znf228 (aka e3 ubiquitin-protein ligase rnf114)
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Using methylation-sensitive restriction enzymes, we also observed significant hypomethylation at several sites tested within the mouse rDNA repeats in Atrxnull ES cells and 12-d embryoid bodies relative to ES cells and embryoid bodies bearing a functional Atrx allele (AtrxWT or Atrxflox) (Figure 3B and 3C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: hdll4 (aka delta-like protein 4 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The observation that rDNA is hypomethylated in the absence of Atrx, even in ES cells, is consistent with the finding that hypomethylation of the human rDNA repeats is detectable from an early developmental stage in ATR-X patients.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: znf313 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'These repeats were found to be moderately (Line 1 and Sine B1) or highly (IAP, major satellite, minor satellite) methylated in wild-type ES cells, and this methylation was not detectably perturbed by the absence of Atrx (Figure S3 and unpublished data).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Taken together, these data indicate that the subtle interplay between the ATRX protein and DNA methylation observed in human patients is also present in mouse cells.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: znf313 (aka e3 ubiquitin-protein ligase rnf114)
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Early Embryonic Lethality in Atrxnull Male Mice
To investigate the role of the Atrx protein during mouse development, we initially established lines of mice bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Early Embryonic Lethality in Atrxnull Male Mice
To investigate the role of the Atrx protein during mouse development, we initially established lines of mice bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'Early Embryonic Lethality in Atrxnull Male Mice
To investigate the role of the Atrx protein during mouse development, we initially established lines of mice bearing the Atrxflox allele.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Two independently targeted Atrxflox ES cell clones with normal male karyotype were injected into C57BL/6 blastocysts to produce chimaeric mice, which were then used to obtain germline transmission.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'Intercrosses between males hemizygous (Atrxflox/Y) and females heterozygous (AtrxWT/flox) for the floxed allele were also carried out to generate homozygous females (Atrxflox/flox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: hdll4 (aka delta-like protein 4 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Intercrosses between males hemizygous (Atrxflox/Y) and females heterozygous (AtrxWT/flox) for the floxed allele were also carried out to generate homozygous females (Atrxflox/flox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Intercrosses between males hemizygous (Atrxflox/Y) and females heterozygous (AtrxWT/flox) for the floxed allele were also carried out to generate homozygous females (Atrxflox/flox).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Males hemizygous and females heterozygous or homozygous for the Atrxflox allele were viable, appeared healthy, and bred normally, suggesting that, as expected, the Atrxflox allele was functionally normal.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: znf228 (aka e3 ubiquitin-protein ligase rnf114)
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Males hemizygous and females heterozygous or homozygous for the Atrxflox allele were viable, appeared healthy, and bred normally, suggesting that, as expected, the Atrxflox allele was functionally normal.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
I: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice by Cre-mediated recombination, the Atrxflox mice were crossed with mice harboring a transgene in which the Cre recombinase is expressed under the control of the regulatory elements of the mouse GATA-1 gene (GATA1-cre)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf313 (aka e3 ubiquitin-protein ligase rnf114)
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice by Cre-mediated recombination, the Atrxflox mice were crossed with mice harboring a transgene in which the Cre recombinase is expressed under the control of the regulatory elements of the mouse GATA-1 gene (GATA1-cre)', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: znf228 (aka e3 ubiquitin-protein ligase rnf114)
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice by Cre-mediated recombination, the Atrxflox mice were crossed with mice harboring a transgene in which the Cre recombinase is expressed under the control of the regulatory elements of the mouse GATA-1 gene (GATA1-cre)', select the correct biomedical concept corresponding to 'gata-1'. Answer using one of the provided options. | <Options>: A: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
B: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
C: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
D: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
E: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
F: mitotic checkpoint protein bub3 phosphorylated 1 (bub3/phos:1) (aka mitotic checkpoint protein bub3 phosphorylated 1)
G: ovarian cancer-related tumor marker ca125 (aka mucin-16)
H: immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50) (staphylococcal protein a (staphylococcus aureus subsp. aureus mu50)) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
I: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
J: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice by Cre-mediated recombination, the Atrxflox mice were crossed with mice harboring a transgene in which the Cre recombinase is expressed under the control of the regulatory elements of the mouse GATA-1 gene (GATA1-cre)', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: igg-binding protein a (staphylococcus aureus subsp. aureus mu50) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
B: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
C: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
D: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
E: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
F: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
G: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
H: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
I: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
J: tripartite motif-containing protein 72 isoform 1 (trim72/iso:1) (aka tripartite motif-containing protein 72 isoform 1)
K: None of the above. | K |
<Instruct>: Given the context 'Widespread expression of the GATA1-cre transgene has been demonstrated during early embryogenesis [14].', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: igg-binding protein a (staphylococcus aureus subsp. aureus mu50) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
B: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
C: homeobox protein hox-b4a (zebrafish) (zf13 (aka homeobox protein hox-b4a (zebrafish)))
D: tripartite motif-containing protein 72 isoform 1 (trim72/iso:1) (aka tripartite motif-containing protein 72 isoform 1)
E: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
F: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
G: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
H: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
I: transmembrane protein 91 isoform 1 (tmem91/iso:1) (aka transmembrane protein 91 isoform 1)
J: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
K: None of the above. | K |
<Instruct>: Given the context 'We more accurately defined the onset of GATA1-cre expression using a ROSA26 reporter strain, in which a Ξ²-galactosidase/neor fusion reporter gene is expressed only after Cre-mediated excision of loxP-flanked transcription and translation termination signals [14].', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
B: igg-binding protein a (staphylococcus aureus subsp. aureus mu50) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
C: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
D: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
E: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
F: trim72/iso:1 (aka tripartite motif-containing protein 72 isoform 1)
G: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
H: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
I: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
J: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We found that the GATA1-cre transgene was already active at the 16-cell morula stage of development (0.5 days postcoitus [dpc]) (Figure 4A).
', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: mitotic checkpoint protein bub3 phosphorylated 1 (bub3/phos:1) (aka mitotic checkpoint protein bub3 phosphorylated 1)
B: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
C: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
D: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
E: tripartite motif-containing protein 72 isoform 1 (trim72/iso:1) (aka tripartite motif-containing protein 72 isoform 1)
F: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
G: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
H: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
I: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
J: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice, heterozygous floxed females (AtrxWT/flox) were mated with homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: hdll4 (aka delta-like protein 4 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice, heterozygous floxed females (AtrxWT/flox) were mated with homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hythdf1 (aka yth domain-containing family protein 1 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
G: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice, heterozygous floxed females (AtrxWT/flox) were mated with homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice, heterozygous floxed females (AtrxWT/flox) were mated with homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+).', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: transmembrane protein 91 isoform 1 (tmem91/iso:1) (aka transmembrane protein 91 isoform 1)
B: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
C: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
D: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
E: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
F: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
G: trim72/iso:1 (aka tripartite motif-containing protein 72 isoform 1)
H: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
I: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
J: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To generate Atrxnull mice, heterozygous floxed females (AtrxWT/flox) were mated with homozygous GATA1-cre transgenic males (AtrxWT/Y;GATA1-cre+/+).', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
B: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
C: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
D: trim72/iso:1 (aka tripartite motif-containing protein 72 isoform 1)
E: igg-binding protein a (staphylococcus aureus subsp. aureus mu50) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
F: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
G: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
H: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
I: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
J: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No Atrxnull males (Atrxnull/Y;GATA1-cre+/β) were recovered at birth, indicating that the absence of Atrx results in embryonic lethality.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No Atrxnull males (Atrxnull/Y;GATA1-cre+/β) were recovered at birth, indicating that the absence of Atrx results in embryonic lethality.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No Atrxnull males (Atrxnull/Y;GATA1-cre+/β) were recovered at birth, indicating that the absence of Atrx results in embryonic lethality.', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50) (staphylococcal protein a (staphylococcus aureus subsp. aureus mu50)) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
B: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
C: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
D: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
E: transmembrane protein 91 isoform 1 (tmem91/iso:1) (aka transmembrane protein 91 isoform 1)
F: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
G: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
H: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
I: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
J: bub3/phos:1 (aka mitotic checkpoint protein bub3 phosphorylated 1)
K: None of the above. | K |
<Instruct>: Given the context 'No Atrxnull males (Atrxnull/Y;GATA1-cre+/β) were recovered at birth, indicating that the absence of Atrx results in embryonic lethality.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Atrxnull males were present at expected mendelian ratios (~25%) at both 7.5 dpc and 8.5 dpc (Table 1).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'However, by 9.5 dpc, depletion was observed both in the number of Atrxnull males (7%) and in the total number of males recovered (31%).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hdll4 (aka delta-like protein 4 (human))
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No Atrxnull males were recovered after 9.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Thus the absence of Atrx gives rise to embryonic lethality in mice before 9.5 dpc.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: hdll4 (aka delta-like protein 4 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To investigate the morphology of Atrxnull embryos prior to death, embryos from the above crosses were initially dissected in their deciduas at 7.5 dpc, and paraffin sections were stained with haematoxylin (Figure 5A) or with an anti-ATRX antibody (Figure 5Bβ5E).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'To investigate the morphology of Atrxnull embryos prior to death, embryos from the above crosses were initially dissected in their deciduas at 7.5 dpc, and paraffin sections were stained with haematoxylin (Figure 5A) or with an anti-ATRX antibody (Figure 5Bβ5E).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Immunohistochemical staining revealed that Atrx was widely expressed in wild-type 7.5 dpc embryos (Figure 5B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: hdll4 (aka delta-like protein 4 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
G: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
H: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We also observed very high levels of Atrx expression in trophoblast giant cells (TGCs) surrounding the Reichert's membrane (Figure 5E).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: hdll4 (aka delta-like protein 4 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Within the large nuclei of these TGCs, the typical nuclear association of Atrx with blocks of pericentromeric heterochromatin [15] was clearly observable.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Morphologically, 7.5 dpc Atrxnull embryos were dramatically reduced in size and appeared developmentally retarded relative to stage-matched wild-type embryos (Figure 5A and 5B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
E: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'However, despite their reduced size, the general morphology and organisation of embryonic structures in Atrxnull conceptuses appeared grossly normal.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'The head fold had clearly formed, and expression of the early mesoderm marker brachyury (T)', select the correct biomedical concept corresponding to 'brachyury'. Answer using one of the provided options. | <Options>: A: krr1 small subunit processome component homolog (human) (hkrr1) (aka krr1 small subunit processome component homolog (human))
B: olfactory receptor 5i1 (human) (hor5i1) (aka olfactory receptor 5i1 (human))
C: olfactory receptor 2f1 (human) (hor2f1) (aka olfactory receptor 2f1 (human))
D: hsrf (aka serum response factor (human)) (aka serum response factor (human))
E: at-acp1 (aka acyl carrier protein 1, chloroplastic (arabidopsis thaliana))
F: ptpn18 (aka tyrosine-protein phosphatase non-receptor type 18)
G: krr1 small subunit processome component homolog isoform h1 (human) (hkrr1/iso:h1) (aka krr1 small subunit processome component homolog isoform h1 (human))
H: krr1 small subunit processome component homolog isoform h2 (human) (hkrr1/iso:h2) (aka krr1 small subunit processome component homolog isoform h2 (human))
I: amino acid biosynthesis regulatory protein (yeast) (aka general control protein gcn4 (yeast))
J: None of the above. | J |
<Instruct>: Given the context 'The head fold had clearly formed, and expression of the early mesoderm marker brachyury (T)', select the correct biomedical concept corresponding to 't'. Answer using one of the provided options. | <Options>: A: hor5i1 (aka olfactory receptor 5i1 (human))
B: rhomboid-related protein 1 isoform h1 (human) (hrhbdl1/iso:h1) (aka rhomboid-related protein 1 isoform h1 (human))
C: hsrf (aka serum response factor (human)) (aka serum response factor (human))
D: krr1 small subunit processome component homolog isoform h1 (human) (hkrr1/iso:h1) (aka krr1 small subunit processome component homolog isoform h1 (human))
E: staph-enta(toxin) (aka enterotoxin type a (staphylococcus aureus))
F: at-acp1 (aka acyl carrier protein 1, chloroplastic (arabidopsis thaliana))
G: general control protein gcn4 (yeast) (amino acid biosynthesis regulatory protein (yeast)) (aka general control protein gcn4 (yeast))
H: zinc finger homeobox protein 2 (zinc finger homeodomain protein 2) (aka zinc finger homeobox protein 2)
I: ribophorin i (rat) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (rat))
J: ylr058c (aka serine hydroxymethyltransferase, cytosolic (yeast))
K: None of the above. | K |
<Instruct>: Given the context '[16] was detected in the primitive streak and emerging notochord by whole-mount in situ hybridisation (WMISH) (Figure 5F), indicating that Atrxnull embryos had gastrulated.
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hdll4 (aka delta-like protein 4 (human))
I: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'To investigate whether the reduced size of the Atrxnull embryos was due to an increase in apoptosis, we analysed sections of paraffin-embedded 7.5 dpc embryos by TdT-mediated dUTP nick end labeling (TUNEL) assay (Figure 6A).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
B: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: hdll4 (aka delta-like protein 4 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'In Atrxnull embryos, a slight increase in the apoptotic population was evident.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: znf313 (aka e3 ubiquitin-protein ligase rnf114)
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'However, consistent with our observation of a grossly normal apoptotic index in Atrxnull ES cells (Figure S2), the apoptotic response observed in Atrxnull embryos was also not uniform, but was restricted to a low number of scattered TUNEL-positive cells.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'However, consistent with our observation of a grossly normal apoptotic index in Atrxnull ES cells (Figure S2), the apoptotic response observed in Atrxnull embryos was also not uniform, but was restricted to a low number of scattered TUNEL-positive cells.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: hdll4 (aka delta-like protein 4 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Since this small apoptotic response is unlikely to account fully for the dramatic size deficit observed in Atrxnull embryos, a possible proliferation defect was also investigated by immunohistochemical staining of 7.5 dpc embryo sections for the mitosis marker phosphorylated (Ser10) histone H3', select the correct biomedical concept corresponding to 'histone h3'. Answer using one of the provided options. | <Options>: A: hkbtbd12/iso:h1 (aka kelch repeat and btb domain-containing protein 12 isoform h1 (human))
B: hlexm (aka lymphocyte expansion molecule (human))
C: worm-c50c3.1 (aka uncharacterized protein c50c3.1 (caenorhabditis elegans))
D: lymphocyte expansion molecule isoform h1 (human) (hlexm/iso:h1) (aka lymphocyte expansion molecule isoform h1 (human))
E: membrane protein fam174b (human) (hfam174b) (aka membrane protein fam174b (human))
F: htimm50 (aka mitochondrial import inner membrane translocase subunit tim50 (human))
G: hanxa2r (aka annexin-2 receptor (human))
H: ybmt6 (aka 25s rrna (uridine(2843)-n(3))-methyltransferase (yeast))
I: uncharacterized calcium-binding protein c50c3.5 (caenorhabditis elegans) (worm-c50c3.5) (aka uncharacterized calcium-binding protein c50c3.5 (caenorhabditis elegans))
J: worm-prpf8 (aka pre-mrna-splicing factor 8 homolog (caenorhabditis elegans))
K: None of the above. | K |
<Instruct>: Given the context 'Since this small apoptotic response is unlikely to account fully for the dramatic size deficit observed in Atrxnull embryos, a possible proliferation defect was also investigated by immunohistochemical staining of 7.5 dpc embryo sections for the mitosis marker phosphorylated (Ser10) histone H3', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Taken together, these results suggest that the size deficit observed in Atrxnull embryos prior to lethality largely reflects a proliferative defect, with a minor but indirect contribution from increased apoptosis.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
F: znf228 (aka e3 ubiquitin-protein ligase rnf114)
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Although a growth defect was also observed in Atrxnull ES cells (Figure 3A), in contrast to the Atrxnull embryos, the mitotic index of the ES cell population (as measured with the same antibody) was not depleted (Figure S1B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Although a growth defect was also observed in Atrxnull ES cells (Figure 3A), in contrast to the Atrxnull embryos, the mitotic index of the ES cell population (as measured with the same antibody) was not depleted (Figure S1B).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'These observations suggest that the mitotic defect observed in embryos is unlikely to be a direct, cell-autonomous effect of the absence of Atrx, and is more likely to be a secondary effect resulting from the failure to develop a normal trophoblast (see below).
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: znf228 (aka e3 ubiquitin-protein ligase rnf114)
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Trophectoderm Failure in Atrxnull Embryos
Whole-mount observation of 8.5 dpc embryos revealed that, in contrast to the basically normal although delayed morphology of the embryo itself, the extraembryonic tissues of Atrxnull conceptuses appeared highly disorganised.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
G: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
H: hdll4 (aka delta-like protein 4 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: znf228 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Trophectoderm Failure in Atrxnull Embryos
Whole-mount observation of 8.5 dpc embryos revealed that, in contrast to the basically normal although delayed morphology of the embryo itself, the extraembryonic tissues of Atrxnull conceptuses appeared highly disorganised.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: hdll4 (aka delta-like protein 4 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
F: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'When embryos were removed from deciduas, the surrounding trophectoderm layer appeared dramatically reduced in Atrxnull embryos relative to wild-type littermates, and the underlying ectoplacental cone appeared reduced and abnormally shaped (Figure 7A).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: hdll4 (aka delta-like protein 4 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'Vacated deciduas surrounding 8.5 dpc wild-type and Atrxnull embryos were bisected and analysed by WMISH for expression of placental lactogen-1 (Pl-1), a marker of terminally differentiated TGCs.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Vacated deciduas surrounding 8.5 dpc wild-type and Atrxnull embryos were bisected and analysed by WMISH for expression of placental lactogen-1 (Pl-1), a marker of terminally differentiated TGCs.', select the correct biomedical concept corresponding to 'placental lactogen-1'. Answer using one of the provided options. | <Options>: A: s phase cyclin a-associated protein in the er (aka s phase cyclin a-associated protein in the endoplasmic reticulum)
B: fhl5/iso:1 (aka four and a half lim domains protein 5 isoform 1)
C: bmzf3 (aka zinc finger protein 256)
D: zinc finger protein 259 (aka zinc finger protein zpr1)
E: mtnd3 (aka nadh-ubiquinone oxidoreductase chain 3 (chicken))
F: kiaa0199 (aka sterol regulatory element-binding protein cleavage-activating protein)
G: hydroxylysine kinase (human) (hhykk) (aka hydroxylysine kinase (human))
H: hhykk/iso:h2 (aka hydroxylysine kinase isoform h2 (human))
I: ynl082w (aka dna mismatch repair protein pms1 (yeast))
J: hydroxylysine kinase isoform h3 (human) (hhykk/iso:h3) (aka hydroxylysine kinase isoform h3 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Vacated deciduas surrounding 8.5 dpc wild-type and Atrxnull embryos were bisected and analysed by WMISH for expression of placental lactogen-1 (Pl-1), a marker of terminally differentiated TGCs.', select the correct biomedical concept corresponding to 'pl-1'. Answer using one of the provided options. | <Options>: A: type-ii keratin kb4 (aka keratin, type ii cytoskeletal 4)
B: zgc:92267 (aka mitochondrial fission regulator 1 (zebrafish))
C: fadr/initmet- (aka fatty acid metabolism regulator protein, initiator methionine removed form)
D: tfec/iso:1 (aka transcription factor ec isoform 1)
E: polymerase acidic protein (influenza a virus) (flua-pa/iso:pa) (aka polymerase acidic protein (influenza a virus))
F: k39 (aka keratin, type i cytoskeletal 39) (aka keratin, type i cytoskeletal 39)
G: mitogen-activated protein kinase 9 isoform 4 (mapk9/iso:4) (aka mitogen-activated protein kinase 9 isoform 4)
H: outer dense fiber protein 4 (outer dense fiber of sperm tails protein 4) (aka outer dense fiber protein 4)
I: cg4746 (aka protein mab-21 (fruit fly))
J: scn8a/iso:3 (aka sodium channel protein type 8 subunit alpha isoform 3)
K: None of the above. | K |
<Instruct>: Given the context 'The number of Pl-1-expressing cells attached to the decidual wall after removal of the embryo is an indication of the density of trophoblast cells surrounding each implantation site [17].', select the correct biomedical concept corresponding to 'pl-1'. Answer using one of the provided options. | <Options>: A: hha7 (aka keratin, type i cuticular ha7) (aka keratin, type i cuticular ha7)
B: polymerase acidic protein (influenza a virus) (flua-pa/iso:pa) (aka polymerase acidic protein (influenza a virus))
C: zgc:92267 (aka mitochondrial fission regulator 1 (zebrafish))
D: type-ii keratin kb4 (aka keratin, type ii cytoskeletal 4)
E: flu-pa (aka influenzavirus pa gene translation product)
F: scn8a/iso:3 (aka sodium channel protein type 8 subunit alpha isoform 3)
G: ka35 (aka keratin, type i cytoskeletal 39) (aka keratin, type i cytoskeletal 39)
H: outer dense fiber protein 4 (outer dense fiber of sperm tails protein 4) (aka outer dense fiber protein 4)
I: protein it (aka keratin, type i cytoskeletal 20)
J: histone h2b type 1-o, initiator methionine removed acetylated 6 (human) (uniprotkb:p23527, 2-126, lys-121, mod:00723) (aka histone h2b type 1-o, initiator methionine removed acetylated 6 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We found that the population of Pl-1-expressing cells was depleted in the decidual implantation sites containing Atrxnull embryos relative to those containing wild-type littermates (Figure 7B); this was also apparent at 7.5 dpc, as determined by immunohistochemical staining of paraffin sections of embryos in deciduas with an anti-Pl-1 antibody (Figure 7C).', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: znf313 (aka e3 ubiquitin-protein ligase rnf114)
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
K: None of the above. | K |
<Instruct>: Given the context 'We found that the population of Pl-1-expressing cells was depleted in the decidual implantation sites containing Atrxnull embryos relative to those containing wild-type littermates (Figure 7B); this was also apparent at 7.5 dpc, as determined by immunohistochemical staining of paraffin sections of embryos in deciduas with an anti-Pl-1 antibody (Figure 7C).', select the correct biomedical concept corresponding to 'pl-1'. Answer using one of the provided options. | <Options>: A: hha7 (aka keratin, type i cuticular ha7) (aka keratin, type i cuticular ha7)
B: zmtfr1 (aka mitochondrial fission regulator 1 (zebrafish))
C: flu-pa (aka influenzavirus pa gene translation product)
D: type-ii keratin kb4 (aka keratin, type ii cytoskeletal 4)
E: fadr/initmet- (aka fatty acid metabolism regulator protein, initiator methionine removed form)
F: scn8a/iso:3 (aka sodium channel protein type 8 subunit alpha isoform 3)
G: keratin-5 (aka keratin, type i cuticular ha6)
H: ka35 (aka keratin, type i cytoskeletal 39) (aka keratin, type i cytoskeletal 39)
I: tfec/iso:1 (aka transcription factor ec isoform 1)
J: polymerase acidic protein (influenza a virus) (flua-pa/iso:pa) (aka polymerase acidic protein (influenza a virus))
K: None of the above. | K |
<Instruct>: Given the context 'We found that the population of Pl-1-expressing cells was depleted in the decidual implantation sites containing Atrxnull embryos relative to those containing wild-type littermates (Figure 7B); this was also apparent at 7.5 dpc, as determined by immunohistochemical staining of paraffin sections of embryos in deciduas with an anti-Pl-1 antibody (Figure 7C).', select the correct biomedical concept corresponding to 'pl-1'. Answer using one of the provided options. | <Options>: A: ck-20 (aka keratin, type i cytoskeletal 20)
B: polymerase acidic protein (influenza a virus) (flua-pa/iso:pa) (aka polymerase acidic protein (influenza a virus))
C: histone h2b type 1-o, initiator methionine removed acetylated 6 (human) (uniprotkb:p23527, 2-126, lys-121, mod:00723) (aka histone h2b type 1-o, initiator methionine removed acetylated 6 (human))
D: zgc:92267 (aka mitochondrial fission regulator 1 (zebrafish))
E: outer dense fiber protein 4 (outer dense fiber of sperm tails protein 4) (aka outer dense fiber protein 4)
F: tfec/iso:1 (aka transcription factor ec isoform 1)
G: hha7 (aka keratin, type i cuticular ha7) (aka keratin, type i cuticular ha7)
H: ka35 (aka keratin, type i cytoskeletal 39) (aka keratin, type i cytoskeletal 39)
I: scn8a/iso:3 (aka sodium channel protein type 8 subunit alpha isoform 3)
J: mitogen-activated protein kinase 9 isoform 4 (mapk9/iso:4) (aka mitogen-activated protein kinase 9 isoform 4)
K: None of the above. | K |
<Instruct>: Given the context 'A TGC deficiency in the absence of Atrx is consistent with the observation that Atrx is highly expressed in giant cells surrounding wild-type 7.5 dpc embryos (Figure 5E).
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: znf313 (aka e3 ubiquitin-protein ligase rnf114)
F: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'A TGC deficiency in the absence of Atrx is consistent with the observation that Atrx is highly expressed in giant cells surrounding wild-type 7.5 dpc embryos (Figure 5E).
', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
B: hdll4 (aka delta-like protein 4 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'To investigate whether the trophoblast defect was restricted to the production of secondary TGCs (produced by diploid precursors in the ectoplacental cone and derived originally from the polar trophectoderm overlying the inner cell mass of the blastocyst) or also affected the production of primary TGCs (resulting from differentiation of the mural trophectoderm of the blastocyst), blastocysts (3.5 dpc) from crosses between AtrxWT/flox females and GATA1-Cre homozygous transgenic males (AtrxWT/Y;GATA1-Cre+/+) were cultured in vitro for 5 d to monitor outgrowth of the primary trophoblast.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
G: hythdf1 (aka yth domain-containing family protein 1 (human))
H: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
K: None of the above. | K |
<Instruct>: Given the context 'To investigate whether the trophoblast defect was restricted to the production of secondary TGCs (produced by diploid precursors in the ectoplacental cone and derived originally from the polar trophectoderm overlying the inner cell mass of the blastocyst) or also affected the production of primary TGCs (resulting from differentiation of the mural trophectoderm of the blastocyst), blastocysts (3.5 dpc) from crosses between AtrxWT/flox females and GATA1-Cre homozygous transgenic males (AtrxWT/Y;GATA1-Cre+/+) were cultured in vitro for 5 d to monitor outgrowth of the primary trophoblast.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
K: None of the above. | K |
<Instruct>: Given the context 'To investigate whether the trophoblast defect was restricted to the production of secondary TGCs (produced by diploid precursors in the ectoplacental cone and derived originally from the polar trophectoderm overlying the inner cell mass of the blastocyst) or also affected the production of primary TGCs (resulting from differentiation of the mural trophectoderm of the blastocyst), blastocysts (3.5 dpc) from crosses between AtrxWT/flox females and GATA1-Cre homozygous transgenic males (AtrxWT/Y;GATA1-Cre+/+) were cultured in vitro for 5 d to monitor outgrowth of the primary trophoblast.', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: homeobox protein hox-b4a (zebrafish) (zf13 (aka homeobox protein hox-b4a (zebrafish)))
B: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
C: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
D: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
E: bub3/phos:1 (aka mitotic checkpoint protein bub3 phosphorylated 1)
F: trim72/iso:1 (aka tripartite motif-containing protein 72 isoform 1)
G: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
H: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
I: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
J: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
K: None of the above. | K |
<Instruct>: Given the context 'To investigate whether the trophoblast defect was restricted to the production of secondary TGCs (produced by diploid precursors in the ectoplacental cone and derived originally from the polar trophectoderm overlying the inner cell mass of the blastocyst) or also affected the production of primary TGCs (resulting from differentiation of the mural trophectoderm of the blastocyst), blastocysts (3.5 dpc) from crosses between AtrxWT/flox females and GATA1-Cre homozygous transgenic males (AtrxWT/Y;GATA1-Cre+/+) were cultured in vitro for 5 d to monitor outgrowth of the primary trophoblast.', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: transcription elongation factor b polypeptide 3c-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
B: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
C: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
D: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
E: bub3/phos:1 (aka mitotic checkpoint protein bub3 phosphorylated 1)
F: immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50) (staphylococcal protein a (staphylococcus aureus subsp. aureus mu50)) (aka immunoglobulin g-binding protein a (staphylococcus aureus subsp. aureus mu50))
G: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
H: hoxb4 (aka homeobox protein hox-b4a (zebrafish))
I: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
J: cell division cycle protein 20 phosphorylated 2 (human) (p55cdc phsphorylated (human)) (aka cell division cycle protein 20 phosphorylated 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'After 5 d, individual blastocyst cultures were scored for the extent of primary trophoblast outgrowth, and the Atrx genotype and sex of the blastocyst were determined by PCR.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
B: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
C: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
B: hdll4 (aka delta-like protein 4 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
I: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
J: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
D: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf313 (aka e3 ubiquitin-protein ligase rnf114)
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
F: hdll4 (aka delta-like protein 4 (human))
G: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
B: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
C: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
I: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
J: hdll4 (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'No difference was observed in the rate or extent of trophoblast outgrowth over 5 d of culture between Atrxnull blastocysts (Atrxnull/Y, n = 6) and blastocysts bearing an AtrxWT allele (AtrxWT/WT, n = 6; AtrxWT/null, n = 6; AtrxWT/Y, n = 6) (examples shown in Figure 7D), suggesting that the defect specifically involves the secondary giant cell compartment.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: zfp228 (aka e3 ubiquitin-protein ligase rnf114)
E: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
F: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'This is consistent with the observation that Atrxnull conceptuses implant successfully and survive to gastrulation.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: znf228 (aka e3 ubiquitin-protein ligase rnf114)
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
D: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
E: hdll4 (aka delta-like protein 4 (human))
F: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
G: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
H: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
I: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
J: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Taken together, these data suggest that loss of Atrx results in a defect in formation of the secondary trophoblast that is apparent from 7.5 dpc.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: zinc finger protein 313 (aka e3 ubiquitin-protein ligase rnf114)
D: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: hdll4 (aka delta-like protein 4 (human))
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
I: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
J: hythdf1 (aka yth domain-containing family protein 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
B: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
C: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: znf313 (aka e3 ubiquitin-protein ligase rnf114)
G: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
H: hythdf1 (aka yth domain-containing family protein 1 (human))
I: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
J: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: hythdf1 (aka yth domain-containing family protein 1 (human))
B: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
E: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
F: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: znf313 (aka e3 ubiquitin-protein ligase rnf114)
J: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
B: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
C: hythdf1 (aka yth domain-containing family protein 1 (human))
D: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
E: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
F: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
G: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
H: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
I: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
J: rnf115 (aka e3 ubiquitin-protein ligase rnf115)
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: yth domain-containing family protein 1 isoform 1 (human) (hythdf1/iso:1) (aka yth domain-containing family protein 1 isoform 1 (human))
B: hythdf1 (aka yth domain-containing family protein 1 (human))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
E: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
F: znf228 (aka e3 ubiquitin-protein ligase rnf114)
G: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
B: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
C: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
D: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
E: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
F: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
G: mitotic checkpoint protein bub3 phosphorylated 1 (bub3/phos:1) (aka mitotic checkpoint protein bub3 phosphorylated 1)
H: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
I: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
J: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
K: None of the above. | K |
<Instruct>: Given the context 'Escape from Imprinted Inactivation of the Paternally Inherited AtrxWT Allele in Extraembryonic Tissues of Carrier Female Mice
Female mice carrying an Atrxnull allele (AtrxWT/null;GATA1-cre+/β) were detected at 9.5 dpc (Table 1) and recovered at birth (unpublished data), although at both time points the number of carrier females was lower than that of wild-type (AtrxWT/WT;GATA1-cre+/β) females, suggesting that a proportion of carrier female embryos died in utero.', select the correct biomedical concept corresponding to 'gata1'. Answer using one of the provided options. | <Options>: A: tmem91/iso:1 (aka transmembrane protein 91 isoform 1)
B: transmembrane protein 182 isoform 1 (tmem182/iso:1) (aka transmembrane protein 182 isoform 1)
C: syntaxin-binding protein 3 (human) (hstxbp3) (aka syntaxin-binding protein 3 (human))
D: elongin-a3-like-1 (aka rna polymerase ii transcription factor siii subunit a3-like-1)
E: mitotic checkpoint protein bub3 phosphorylated 1 (bub3/phos:1) (aka mitotic checkpoint protein bub3 phosphorylated 1)
F: hbub1b/phos:4 (aka mitotic checkpoint serine/threonine-protein kinase bub1 beta phosphorylated 4 (human))
G: rhogap interacting with cip4 homologs protein 1 (aka rho gtpase-activating protein 17)
H: cell division cycle protein 20 phosphorylated 2 (cdc20 phosphorylated) (aka cell division cycle protein 20 phosphorylated 2)
I: penicillinase repressor (staphylococcus epidermidis atcc 12228) (beta-lactamase repressor protein (staphylococcus epidermidis atcc 12228)) (aka penicillinase repressor (staphylococcus epidermidis atcc 12228))
J: staph-ftsz (aka cell division protein ftsz (staphylococcus aureus))
K: None of the above. | K |
<Instruct>: Given the context 'For all AtrxWT/null carrier female embryos presented in Table 1, the AtrxWT allele was paternally derived, while the Atrxnull allele was maternally derived.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
D: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
E: hythdf1 (aka yth domain-containing family protein 1 (human))
F: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
G: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
H: ring finger protein 114 (aka e3 ubiquitin-protein ligase rnf114)
I: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
J: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
K: None of the above. | K |
<Instruct>: Given the context 'For all AtrxWT/null carrier female embryos presented in Table 1, the AtrxWT allele was paternally derived, while the Atrxnull allele was maternally derived.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h2 (human) (he2f5/iso:h2) (aka transcription factor e2f5 isoform h2 (human))
B: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
C: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
D: znf228 (aka e3 ubiquitin-protein ligase rnf114)
E: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
F: hythdf1 (aka yth domain-containing family protein 1 (human))
G: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
H: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
I: e3 ubiquitin-protein ligase rnf115 (zinc finger protein 364) (aka e3 ubiquitin-protein ligase rnf115)
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
<Instruct>: Given the context 'For all AtrxWT/null carrier female embryos presented in Table 1, the AtrxWT allele was paternally derived, while the Atrxnull allele was maternally derived.', select the correct biomedical concept corresponding to 'atrx'. Answer using one of the provided options. | <Options>: A: transcription factor e2f5 isoform h1 (human) (he2f5/iso:h1) (aka transcription factor e2f5 isoform h1 (human))
B: f9n12.12 (aka tetraspanin-10 (arabidopsis thaliana))
C: delta-like protein 4 (human) (hdll4) (aka delta-like protein 4 (human))
D: zinc finger protein 228 (aka e3 ubiquitin-protein ligase rnf114)
E: cytochrome p450 26b1 (human) (hcyp26b1) (aka cytochrome p450 26b1 (human))
F: hythdf1/iso:1 (aka yth domain-containing family protein 1 isoform 1 (human))
G: hmbnl1/iso:h7 (aka muscleblind-like protein 1 isoform h7 (human))
H: yth domain-containing family protein 1 isoform h2 (human) (hythdf1/iso:h2) (aka yth domain-containing family protein 1 isoform h2 (human))
I: hythdf1 (aka yth domain-containing family protein 1 (human))
J: helicase with zinc finger domain 2 (human) (peroxisomal proliferator-activated receptor a-interacting complex 285 kda protein (human)) (aka helicase with zinc finger domain 2 (human))
K: None of the above. | K |
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