instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
B: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
E: ectodysplasin a (bos taurus) (aka ectodysplasin a)
F: None of the above. | [B] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bcl-b (homo sapiens) (aka bcl2 like 10)
B: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
C: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: bcl2l2 (homo sapiens) (aka bcl2 like 2)
E: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
F: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
G: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
H: bis (drosophila melanogaster) (aka bistre)
I: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
J: bcl2l (homo sapiens) (aka bcl2 like 1)
K: None of the above. | [K; E] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: bcl-b (homo sapiens) (aka bcl2 like 10)
C: bcl2l2 (homo sapiens) (aka bcl2 like 2)
D: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
E: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
F: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
G: bcl2l (homo sapiens) (aka bcl2 like 1)
H: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
I: bisc (drosophila melanogaster) (aka biscotti)
J: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
K: None of the above. | [K; E] |
<Instruct>: Given the context 'Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis]
<Options>: A: bis (drosophila melanogaster) (aka bistre)
B: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
E: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
F: None of the above. | [F] |
<Instruct>: Given the context 'Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis]
<Options>: A: bis (mus musculus) (aka bcl2-associated athanogene 3)
B: bis (drosophila melanogaster) (aka bistre)
C: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
D: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
E: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
F: None of the above. | [F] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
B: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
C: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E: bcl2l (homo sapiens) (aka bcl2 like 1)
F: bis (drosophila melanogaster) (aka bistre)
G: ccnb2 (homo sapiens) (aka cyclin b2)
H: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
I: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
J: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
K: None of the above. | [K; A] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bis (mus musculus) (aka bcl2-associated athanogene 3)
B: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
C: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
D: bisc (drosophila melanogaster) (aka biscotti)
E: bis (drosophila melanogaster) (aka bistre)
F: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
G: bcl2l (homo sapiens) (aka bcl2 like 1)
H: bcl2l2 (homo sapiens) (aka bcl2 like 2)
I: ccnb2 (homo sapiens) (aka cyclin b2)
J: bcl-b (homo sapiens) (aka bcl2 like 10)
K: None of the above. | [K; C] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
B: bcl-x (homo sapiens) (aka bcl2 like 1)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
E: bcl2l (homo sapiens) (aka bcl2 like 1)
F: fasps (homo sapiens) (aka period circadian regulator 2)
G: bis (drosophila melanogaster) (aka bistre)
H: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
I: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
J: bcl2 like 2 (homo sapiens) (aka bcl2 like 2)
K: fasn (homo sapiens) (aka fatty acid synthase)
L: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
M: bak-2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
N: bcl2 (homo sapiens) (aka bcl2 apoptosis regulator)
O: bcl-b (homo sapiens) (aka bcl2 like 10)
P: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
Q: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
R: bak1 (homo sapiens) (aka bcl2 antagonist/killer 1)
S: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
T: bis (mus musculus) (aka bcl2-associated athanogene 3)
U: None of the above. | [U; N; Q; P] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
F: fas-as (homo sapiens) (aka fas antisense rna 1)
G: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
H: bcl2l2 (homo sapiens) (aka bcl2 like 2)
I: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
J: fasps (homo sapiens) (aka period circadian regulator 2)
K: fasn (homo sapiens) (aka fatty acid synthase)
L: bak2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
M: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
N: bak1 (homo sapiens) (aka bcl2 antagonist/killer 1)
O: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
P: bis (drosophila melanogaster) (aka bistre)
Q: bax (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
R: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
S: bcl2l (homo sapiens) (aka bcl2 like 1)
T: None of the above. | [T; R; Q; M] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: ccnb2 (homo sapiens) (aka cyclin b2)
F: bak2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
G: bis (mus musculus) (aka bcl2-associated athanogene 3)
H: bcl-x (homo sapiens) (aka bcl2 like 1)
I: bcl-b (homo sapiens) (aka bcl2 like 10)
J: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
K: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
L: bcl2l (homo sapiens) (aka bcl2 like 1)
M: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
N: fasn (homo sapiens) (aka fatty acid synthase)
O: fasas (homo sapiens) (aka fas antisense rna 1)
P: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
Q: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
R: bcl2-l-2 (homo sapiens) (aka bcl2 like 2)
S: bis (drosophila melanogaster) (aka bistre)
T: None of the above. | [T; J; C; A] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bis (drosophila melanogaster) (aka bistre)
E: bak-2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
F: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
G: bcl-x (homo sapiens) (aka bcl2 like 1)
H: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
I: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
J: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
K: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
L: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
M: fas (gallus gallus) (aka fas cell surface death receptor)
N: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
O: bcl2l (homo sapiens) (aka bcl2 like 1)
P: bcl2l2 (homo sapiens) (aka bcl2 like 2)
Q: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
R: fas-as (homo sapiens) (aka fas antisense rna 1)
S: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
T: fasps (homo sapiens) (aka period circadian regulator 2)
U: None of the above. | [U; K; A; N] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2 like 2 (homo sapiens) (aka bcl2 like 2)
B: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: ccnb2 (homo sapiens) (aka cyclin b2)
D: bis (mus musculus) (aka bcl2-associated athanogene 3)
E: bisc (drosophila melanogaster) (aka biscotti)
F: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
G: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
H: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
I: bcl2l (homo sapiens) (aka bcl2 like 1)
J: bis (drosophila melanogaster) (aka bistre)
K: None of the above. | [K; F] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2-l-2 (homo sapiens) (aka bcl2 like 2)
B: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
C: ccnb2 (homo sapiens) (aka cyclin b2)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bisc (drosophila melanogaster) (aka biscotti)
F: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
G: bcl-b (homo sapiens) (aka bcl2 like 10)
H: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
I: bcl2 (homo sapiens) (aka bcl2 apoptosis regulator)
J: bis (mus musculus) (aka bcl2-associated athanogene 3)
K: None of the above. | [K; I] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of metastases that are resistant to tamoxifen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1; p130cas]
<Options>: A: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: p120cas (xenopus tropicalis) (aka catenin delta 1)
E: p130cas (xenopus laevis) (bcar1, cas family scaffold protein s homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein s homeolog)
F: p120cas (homo sapiens) (aka catenin delta 1)
G: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
H: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
I: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of metastases that are resistant to tamoxifen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: p120cas (xenopus tropicalis) (aka catenin delta 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
F: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
G: p130cas (xenopus laevis) (bcar1, cas family scaffold protein s homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein s homeolog)
H: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
I: p120cas (homo sapiens) (aka catenin delta 1)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar3 antisense rna 1 (homo sapiens) (aka bcar3 antisense rna 1)
D: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
E: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
F: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
G: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
H: bcar1 (sus scrofa) (aka bcar1 scaffold protein, cas family member)
I: breast cancer associated esr1 regulating natural antisense transcript 1 (homo sapiens) (aka breast cancer associated esr1 regulating natural antisense transcript 1)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: breast cancer anti-estrogen resistance 4 (homo sapiens) (aka breast cancer anti-estrogen resistance 4)
E: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
F: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
G: bcan antisense rna 1 (homo sapiens) (aka bcan antisense rna 1)
H: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
I: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
F: None of the above. | [D] |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
F: None of the above. | [A] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
D: p120cas (homo sapiens) (aka catenin delta 1)
E: cas1 (homo sapiens) (bcar1 scaffold protein, cas family member (homo sapiens)) (aka bcar1 scaffold protein, cas family member)
F: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
G: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
H: p130cas (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
I: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
J: p130cas (xenopus laevis) (bcar1, cas family scaffold protein s homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein s homeolog)
K: None of the above. | [B; C] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: p130cas (sus scrofa) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
F: p130cas (drosophila melanogaster) (aka p130cas)
G: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
H: p130cas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
I: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
J: p130cas (xenopus laevis) (bcar1, cas family scaffold protein s homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein s homeolog)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
E: None of the above. | [E] |
<Instruct>: Given the context 'BCAR1 transcripts were detected in multiple human tissues and were similar in size to transcripts produced by retrovirus-mutated ZR-75-1 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
E: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
F: None of the above. | [E] |
<Instruct>: Given the context 'Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd207 (homo sapiens) (aka cd207 molecule)
B: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
C: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
D: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
E: cd206 (homo sapiens) (aka mannose receptor c-type 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
D: cd207 molecule (homo sapiens) (aka cd207 molecule)
E: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
E: cd207 molecule (homo sapiens) (aka cd207 molecule)
F: None of the above. | [E] |
<Instruct>: Given the context 'Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
E: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
F: None of the above. | [C] |
<Instruct>: Given the context 'Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd206 (homo sapiens) (aka mannose receptor c-type 1)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
E: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
F: None of the above. | [A] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd207 (homo sapiens) (aka cd207 molecule)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
D: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
E: cd206 (homo sapiens) (aka mannose receptor c-type 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
B: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
C: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
D: cd206 (homo sapiens) (aka mannose receptor c-type 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Cloning and characterisation of the Sry-related transcription factor gene Sox8.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (danio rerio) (aka sry-box transcription factor 8b)
B: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
C: sox8 (gallus gallus) (aka sry-box 8)
D: sox8 (sus scrofa) (aka sry-box transcription factor 8)
E: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
F: None of the above. | [E] |
<Instruct>: Given the context 'We report here the isolation of Sox8 and its characterisation in mice and humans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
C: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
D: sox8 (danio rerio) (aka sry-box transcription factor 8b)
E: sox8 (sus scrofa) (aka sry-box transcription factor 8)
F: None of the above. | [A] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox9; sox10]
<Options>: A: sox10 (danio rerio) (aka sry-box transcription factor 10)
B: sox9-b (xenopus laevis) (sry-box 9 s homeolog (xenopus laevis)) (aka sry-box 9 s homeolog)
C: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
D: sox-10 (gallus gallus) (aka sry-box 10)
E: sox10 (xenopus tropicalis) (aka sry-box 10)
F: sox9 (xenopus laevis) (sry-box 9 l homeolog (xenopus laevis)) (aka sry-box 9 l homeolog)
G: sry-box transcription factor 9 (homo sapiens) (aka sry-box transcription factor 9)
H: bobby sox homolog (xenopus tropicalis) (aka bobby sox homolog)
I: sox-10 (homo sapiens) (aka sry-box transcription factor 10)
J: sox9 (gallus gallus) (aka sry-box 9)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox9; sox10]
<Options>: A: sox9 promoter region (homo sapiens) (aka sox9 promoter region)
B: sox9 (xenopus laevis) (sry-box 9 l homeolog (xenopus laevis)) (aka sry-box 9 l homeolog)
C: sox10 (gallus gallus) (aka sry-box 10)
D: sox9-b (xenopus laevis) (sry-box 9 s homeolog (xenopus laevis)) (aka sry-box 9 s homeolog)
E: sox10 (xenopus tropicalis) (aka sry-box 10)
F: sox-10 (homo sapiens) (aka sry-box transcription factor 10)
G: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
H: sox9 (gallus gallus) (aka sry-box 9)
I: sry-box transcription factor 9 (homo sapiens) (aka sry-box transcription factor 9)
J: sox10 (danio rerio) (aka sry-box transcription factor 10)
K: None of the above. | [I; F] |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
B: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
C: sox8 (sus scrofa) (aka sry-box transcription factor 8)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E: sry-box 8 (gallus gallus) (aka sry-box 8)
F: None of the above. | [B] |
<Instruct>: Given the context 'Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (sus scrofa) (aka sry-box transcription factor 8)
B: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
C: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E: sox8 (homo sapiens) (aka sry-box transcription factor 8)
F: None of the above. | [E] |
<Instruct>: Given the context 'Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (danio rerio) (aka sry-box transcription factor 8b)
B: sox8 (sus scrofa) (aka sry-box transcription factor 8)
C: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
D: sox8 (xenopus tropicalis) (aka sry-box 8)
E: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
F: None of the above. | [C] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus tropicalis) (aka syntaphilin)
B: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
E: syntaphilin (sus scrofa) (aka syntaphilin)
F: None of the above. | [C] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus tropicalis) (aka syntaphilin)
B: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
C: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: None of the above. | [E] |
<Instruct>: Given the context 'Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [snap-25]
<Options>: A: snap25 (homo sapiens) (aka synaptosome associated protein 25)
B: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
C: snap-25 (xenopus tropicalis) (aka synaptosome associated protein 25kda)
D: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
E: snap-25 (bos taurus) (aka synaptosome associated protein 25)
F: None of the above. | [A] |
<Instruct>: Given the context 'We have cloned and characterized a protein called syntaphilin that is selectively expressed in brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (sus scrofa) (aka syntaphilin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syntaphilin (xenopus tropicalis) (aka syntaphilin)
F: None of the above. | [C] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin; snap-25]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (homo sapiens) (aka syntaphilin)
C: syn1 (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
D: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
E: snap25 (drosophila melanogaster) (aka synaptosomal-associated protein 25kda)
F: snap-25 (homo sapiens) (aka synaptosome associated protein 25)
G: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
H: snap-25 (bos taurus) (aka synaptosome associated protein 25)
I: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
J: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
K: None of the above. | [B; F] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin; snap-25]
<Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
C: snap-25 (bos taurus) (aka synaptosome associated protein 25)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
F: snap25 (sus scrofa) (aka synaptosome associated protein 25)
G: syntaphilin (bos taurus) (aka syntaphilin)
H: snap-25 (drosophila melanogaster) (aka synaptosomal-associated protein 25kda)
I: synaptosome associated protein 25 (homo sapiens) (aka synaptosome associated protein 25)
J: syntaphilin (xenopus tropicalis) (aka syntaphilin)
K: None of the above. | [A; I] |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: syntaphilin (homo sapiens) (aka syntaphilin)
F: None of the above. | [E] |
<Instruct>: Given the context 'Furthermore, introduction of syntaphilin into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (bos taurus) (aka syntaphilin)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: follicle stimulating hormone receptor (rattus norvegicus) (aka follicle stimulating hormone receptor)
B: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
C: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
D: follicle stimulating hormone receptor (gallus gallus) (aka follicle stimulating hormone receptor)
E: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
F: None of the above. | [E] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
B: follicle stimulating hormone receptor (gallus gallus) (aka follicle stimulating hormone receptor)
C: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
D: follicle stimulating hormone receptor (rattus norvegicus) (aka follicle stimulating hormone receptor)
E: None of the above. | [E] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
C: follicle stimulating hormone receptor (sus scrofa) (aka follicle stimulating hormone receptor)
D: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
E: follicle stimulating hormone receptor (oryctolagus cuniculus) (aka follicle stimulating hormone receptor)
F: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
G: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
H: follicle stimulating hormone receptor (gallus gallus) (aka follicle stimulating hormone receptor)
I: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
B: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: follicle stimulating hormone receptor (gallus gallus) (aka follicle stimulating hormone receptor)
E: follicle stimulating hormone receptor (bos taurus) (aka follicle stimulating hormone receptor)
F: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
G: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
H: follicle stimulating hormone receptor (sus scrofa) (aka follicle stimulating hormone receptor)
I: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'Epitope mapping using synthetic peptides, and truncated hFSH-R variants revealed that mAb 106.156 bound to ECD residues 183-220, while mAbs 106.318, 106.290, 106.263 bound ECD residues 300-331.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r]
<Options>: A: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
B: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
C: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
E: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
F: None of the above. | [E] |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
E: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
D: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
E: neuraminidase 1 (homo sapiens) (aka neuraminidase 1)
F: neuraminidase 3 (homo sapiens) (aka neuraminidase 3)
G: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
H: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
I: n-acetylneuraminic acid phosphatase (homo sapiens) (aka n-acetylneuraminic acid phosphatase)
J: neuraminidase 2 (homo sapiens) (aka neuraminidase 2)
K: None of the above. | [D; E] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: ghr (homo sapiens) (aka growth hormone receptor)
B: neuraminidase 1 (homo sapiens) (aka neuraminidase 1)
C: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
D: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
E: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
F: neuraminidase 1 (rattus norvegicus) (aka neuraminidase 1)
G: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
H: n-acetylneuraminic acid phosphatase (homo sapiens) (aka n-acetylneuraminic acid phosphatase)
I: neuraminidase 3 (homo sapiens) (aka neuraminidase 3)
J: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
K: None of the above. | [E; B] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
D: ghr (homo sapiens) (aka growth hormone receptor)
E: neuraminidase 1 (rattus norvegicus) (aka neuraminidase 1)
F: neuraminidase 3 (homo sapiens) (aka neuraminidase 3)
G: neuraminidase 1 (homo sapiens) (aka neuraminidase 1)
H: n-acetylneuraminic acid phosphatase (homo sapiens) (aka n-acetylneuraminic acid phosphatase)
I: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
J: None of the above. | [J; G] |
<Instruct>: Given the context 'Thus truncated hFSH-R variants do not reach the medial or trans Golgi where high mannose oligosaccharides are trimmed and sialic acid is added.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hfsh-r]
<Options>: A: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
C: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
D: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
E: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'The pro-alpha3(V) collagen chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v) collagen]
<Options>: A: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
E: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
F: None of the above. | [E] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of classical Ehlers-Danlos syndrome (EDS), in which aberrant collagen fibrils are associated with connective tissue fragility, particularly in skin and joints.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
E: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
F: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
G: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
H: vla5a (homo sapiens) (aka integrin subunit alpha 5)
I: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
J: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
K: None of the above. | [B; D] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of classical Ehlers-Danlos syndrome (EDS), in which aberrant collagen fibrils are associated with connective tissue fragility, particularly in skin and joints.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
E: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
F: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
G: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
H: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
I: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
J: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
K: None of the above. | [H; G] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
E: vla5a (homo sapiens) (aka integrin subunit alpha 5)
F: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
G: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
H: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
I: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
J: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
K: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
L: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
M: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
N: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
O: None of the above. | [H; L; N] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla3a (homo sapiens) (aka integrin subunit alpha 3)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
D: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
E: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
F: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
G: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
H: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
I: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
J: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
K: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
L: vla5a (homo sapiens) (aka integrin subunit alpha 5)
M: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
N: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
O: None of the above. | [C; J; B] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
D: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
E: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
F: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
G: vla3a (homo sapiens) (aka integrin subunit alpha 3)
H: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
I: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
J: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
K: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
L: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
M: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
N: None of the above. | [B; A; H] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
D: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
F: None of the above. | [D] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
D: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
E: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
F: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
G: collagen, type v, alpha 1 s homeolog (xenopus laevis) (aka collagen, type v, alpha 1 s homeolog)
H: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
I: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
J: procollagen, type v, alpha 1 (danio rerio) (aka procollagen, type v, alpha 1)
K: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
L: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
M: None of the above. | [B; E; E] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen, type v, alpha 1 s homeolog (xenopus laevis) (aka collagen, type v, alpha 1 s homeolog)
C: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
D: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
E: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
F: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
G: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
H: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
I: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
J: None of the above. | [F; G; G] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
D: apoa-v (rattus norvegicus) (aka apolipoprotein a5)
E: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
F: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
G: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
H: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
I: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
J: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
K: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
L: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
M: None of the above. | [H; I; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
F: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
G: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
H: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
I: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
J: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
K: None of the above. | [H; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
D: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
F: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
G: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
H: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
I: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
J: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
K: None of the above. | [I; D] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: vla3a (homo sapiens) (aka integrin subunit alpha 3)
E: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
F: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
G: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
H: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
I: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
J: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
K: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
L: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
M: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
N: None of the above. | [A; B; G] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
D: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
E: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
F: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
G: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
H: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
I: vla5a (homo sapiens) (aka integrin subunit alpha 5)
J: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
K: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
L: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
M: None of the above. | [H; K; J] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
D: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
E: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
F: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
G: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
H: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
I: vla3a (homo sapiens) (aka integrin subunit alpha 3)
J: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
K: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
L: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
M: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
N: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
O: None of the above. | [L; E; C] |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v)]
<Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
D: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
F: None of the above. | [F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
B: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
E: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
F: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
G: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
H: vla5a (homo sapiens) (aka integrin subunit alpha 5)
I: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
J: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
K: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
L: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
M: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
N: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
O: None of the above. | [K; N; L] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
E: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
F: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
G: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
H: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
I: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
J: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
K: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
L: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
M: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
N: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
O: None of the above. | [B; J; C] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
E: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
F: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
G: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
H: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
I: vla3a (homo sapiens) (aka integrin subunit alpha 3)
J: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
K: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
L: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
M: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
N: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
O: None of the above. | [L; F; N] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
D: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
E: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
F: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
G: col6a3 (homo sapiens) (aka collagen type vi alpha 3 chain)
H: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
I: col5a2 (homo sapiens) (aka collagen type v alpha 2 chain)
J: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
K: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
L: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
M: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
N: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
O: None of the above. | [B; L; D] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col5a3.s (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
E: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
F: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
G: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
H: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
I: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
J: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
K: col6a3 (homo sapiens) (aka collagen type vi alpha 3 chain)
L: vla5a (homo sapiens) (aka integrin subunit alpha 5)
M: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
N: col4a3 (homo sapiens) (aka collagen type iv alpha 3 chain)
O: None of the above. | [I; J; F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
D: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
F: col5a3.s (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
G: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
H: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
I: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
J: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
K: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
L: vla5a (homo sapiens) (aka integrin subunit alpha 5)
M: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
N: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
O: None of the above. | [B; K; M] |
<Instruct>: Given the context 'COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing linkage with EDS and other disease phenotypes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [col5a3]
<Options>: A: col5a3 (homo sapiens) (aka collagen type v alpha 3 chain)
B: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
C: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
D: col4a3 (homo sapiens) (aka collagen type iv alpha 3 chain)
E: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
F: None of the above. | [A] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; p53]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
F: tumor protein p53 (homo sapiens) (aka tumor protein p53)
G: ct53 (homo sapiens) (aka zinc finger protein 165)
H: tumor protein p73 (homo sapiens) (aka tumor protein p73)
I: mdm2bp (homo sapiens) (aka mdm2 binding protein)
J: p53cp (homo sapiens) (aka tumor protein p63)
K: None of the above. | [B; F] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; p53]
<Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: tumor protein p53 (homo sapiens) (aka tumor protein p53)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
E: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
F: ct53 (homo sapiens) (aka zinc finger protein 165)
G: p53cp (homo sapiens) (aka tumor protein p63)
H: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
I: tumor protein p73 (homo sapiens) (aka tumor protein p73)
J: None of the above. | [J; B] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; p53]
<Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: trp53 (homo sapiens) (aka tumor protein p53)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
E: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
F: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
G: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
H: rad53 (homo sapiens) (aka checkpoint kinase 2)
I: tp73 (homo sapiens) (aka tumor protein p73)
J: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
K: None of the above. | [G; B] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: tumor protein p53 (homo sapiens) (aka tumor protein p53)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: rad53 (homo sapiens) (aka checkpoint kinase 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; p53]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
E: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
F: ct53 (homo sapiens) (aka zinc finger protein 165)
G: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
H: tp53 (homo sapiens) (aka tumor protein p53)
I: tp73 (homo sapiens) (aka tumor protein p73)
J: p53cp (homo sapiens) (aka tumor protein p63)
K: None of the above. | [E; H] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: tumor protein p73 (homo sapiens) (aka tumor protein p73)
C: mdm2bp (homo sapiens) (aka mdm2 binding protein)
D: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
G: ct53 (homo sapiens) (aka zinc finger protein 165)
H: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
I: p53 (homo sapiens) (aka tumor protein p53)
J: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: ubiquitin-activating enzyme 1 (arabidopsis thaliana) (aka ubiquitin-activating enzyme 1)
D: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
E: ubiquitin like modifier activating enzyme 1 (xenopus tropicalis) (aka ubiquitin like modifier activating enzyme 1)
F: ubiquitin like modifier activating enzyme 1 (homo sapiens) (aka ubiquitin like modifier activating enzyme 1)
G: ubiquitin like modifier activating enzyme 3 (homo sapiens) (aka ubiquitin like modifier activating enzyme 3)
H: mdm2 proto-oncogene (homo sapiens) (aka mdm2 proto-oncogene)
I: ubiquitin like modifier activating enzyme 7 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
J: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
K: None of the above. | [H; I] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: ubiquitin-like modifier-activating enzyme 1 (gallus gallus) (aka ubiquitin-like modifier-activating enzyme 1)
C: ubiquitin-activating enzyme 1 (arabidopsis thaliana) (aka ubiquitin-activating enzyme 1)
D: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
E: ubiquitin like modifier activating enzyme 1 (xenopus tropicalis) (aka ubiquitin like modifier activating enzyme 1)
F: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
G: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
H: ubiquitin like modifier activating enzyme 7 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
I: ubiquitin like modifier activating enzyme 5 (homo sapiens) (aka ubiquitin like modifier activating enzyme 5)
J: mdm2bp (homo sapiens) (aka mdm2 binding protein)
K: None of the above. | [D; H] |
<Instruct>: Given the context 'It is apparent, therefore, that Mdm2 manifests an intrinsic capacity to mediate ubiquitination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2]
<Options>: A: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
F: None of the above. | [A] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53; mdm2]
<Options>: A: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2bp (homo sapiens) (aka mdm2 binding protein)
E: ct53 (homo sapiens) (aka zinc finger protein 165)
F: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
G: p53 (homo sapiens) (aka tumor protein p53)
H: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
I: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
J: rad53 (homo sapiens) (aka checkpoint kinase 2)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53; mdm2]
<Options>: A: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
B: mdm2bp (homo sapiens) (aka mdm2 binding protein)
C: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: rad53 (homo sapiens) (aka checkpoint kinase 2)
G: p53 (homo sapiens) (aka tumor protein p53)
H: ct53 (homo sapiens) (aka zinc finger protein 165)
I: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
J: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
K: None of the above. | [G; C] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: e3 ubiquitin-protein ligase praja-2 (glycine max) (aka e3 ubiquitin-protein ligase praja-2)
D: keratin associated protein 1-1 (homo sapiens) (aka keratin associated protein 1-1)
E: mdm2bp (homo sapiens) (aka mdm2 binding protein)
F: praja ring finger ubiquitin ligase 2 (homo sapiens) (aka praja ring finger ubiquitin ligase 2)
G: praja ring finger ubiquitin ligase 1 (homo sapiens) (aka praja ring finger ubiquitin ligase 1)
H: pra1 (homo sapiens) (aka rab acceptor 1)
I: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
J: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
K: None of the above. | [I; G] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
D: praja1 (homo sapiens) (aka praja ring finger ubiquitin ligase 1)
E: e3 ubiquitin-protein ligase praja-2 (glycine max) (aka e3 ubiquitin-protein ligase praja-2)
F: praja ring finger ubiquitin ligase 1 (mus musculus) (aka praja ring finger ubiquitin ligase 1)
G: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
H: praja ring finger ubiquitin ligase 1 (bos taurus) (aka praja ring finger ubiquitin ligase 1)
I: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
J: praja ring finger ubiquitin ligase 2 (homo sapiens) (aka praja ring finger ubiquitin ligase 2)
K: None of the above. | [C; D] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2; praja1]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: praja ring finger ubiquitin ligase 1 (bos taurus) (aka praja ring finger ubiquitin ligase 1)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
D: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
E: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
F: praja ring finger ubiquitin ligase 2 (homo sapiens) (aka praja ring finger ubiquitin ligase 2)
G: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
H: praja ring finger ubiquitin ligase 1 (mus musculus) (aka praja ring finger ubiquitin ligase 1)
I: e3 ubiquitin-protein ligase praja-2 (glycine max) (aka e3 ubiquitin-protein ligase praja-2)
J: None of the above. | [G; J] |
<Instruct>: Given the context 'However, this RING was ineffective in ubiquitination and proteasomal targeting of p53, suggesting that there may be specificity at the level of the RING in the recognition of heterologous substrates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: tumor protein p53 (homo sapiens) (aka tumor protein p53)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: rad53 (homo sapiens) (aka checkpoint kinase 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: cd344 (homo sapiens) (aka frizzled class receptor 4)
D: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
E: fat4 (homo sapiens) (aka fat atypical cadherin 4)
F: endoglin (sus scrofa) (aka endoglin)
G: podn (homo sapiens) (aka podocan)
H: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
I: podocalyxin like s homeolog (xenopus laevis) (aka podocalyxin like s homeolog)
J: podocalyxin like (homo sapiens) (aka podocalyxin like)
K: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
L: bgcan (homo sapiens) (aka transforming growth factor beta receptor 3)
M: cd34 molecule (homo sapiens) (aka cd34 molecule)
N: podocalyxin like (gallus gallus) (aka podocalyxin like)
O: eg (homo sapiens) (aka podocalyxin like 2)
P: None of the above. | [O; M; J] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin like (homo sapiens) (aka podocalyxin like)
B: podocalyxin like (bos taurus) (aka podocalyxin like)
C: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
D: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
E: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
F: cd344 (homo sapiens) (aka frizzled class receptor 4)
G: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
H: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
I: cd34 (sus scrofa) (aka cd34 molecule)
J: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
K: endoglin (homo sapiens) (aka endoglin)
L: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
M: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
N: eg (homo sapiens) (aka podocalyxin like 2)
O: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
P: None of the above. | [N; E; A] |
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