instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
B: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
E: ectod... | [B] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl-b (homo sapiens) (aka bcl2 like 10)
B: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
C: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: bcl2l2 (homo sapiens) (aka bcl2 like 2)
E: bcl2 apoptosis regulator (hom... | [K; E] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: bcl-b (homo sapiens) (aka bcl2 like 10)
C: bcl2l2 (homo sapiens) (aka bcl2 like 2)
D: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
E: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
F: bis... | [K; E] |
<Instruct>: Given the context 'Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [bis]
<Options>: A: bis (drosophila melanogaster) (aka bistre)
B: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
E: bis (homo sapiens) (swi/snf ... | [F] |
<Instruct>: Given the context 'Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis]
<Options>: A: bis (mus musculus) (aka bcl2-associated athanogene 3)
B: bis (drosophila melanogaster) (aka bistre)
C: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
D: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
E: bis1 (homo sapiens) (aka ess-2 spli... | [F] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
B: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
C: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E: bcl2l (homo sapiens) (aka bcl2 like 1)
F: bis (drosophila mel... | [K; A] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bis (mus musculus) (aka bcl2-associated athanogene 3)
B: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
C: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
D: bisc (drosophila melanogaster) (aka biscotti)
E: bis (drosophila melanogaster) (aka ... | [K; C] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
B: bcl-x (homo sapiens) (aka bcl2 like 1)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin ... | [U; N; Q; P] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bax (escherichia... | [T; R; Q; M] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
D: fas (gallus gallus) (a... | [T; J; C; A] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bisc (drosophila melanogaster) (aka biscotti)
D: bis (drosophila melanogaster) (aka bistre)
E: bak-2 (homo sapiens) (aka bcl2 ant... | [U; K; A; N] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2 like 2 (homo sapiens) (aka bcl2 like 2)
B: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: ccnb2 (homo sapiens) (aka cyclin b2)
D: bis (mus musculus) (aka bcl2-associated athanogene 3)
E: bisc (drosophila melanogaster) (aka biscotti)
F: bcl2 apoptosi... | [K; F] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2-l-2 (homo sapiens) (aka bcl2 like 2)
B: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
C: ccnb2 (homo sapiens) (aka cyclin b2)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bisc (drosophila melanogaster) (aka biscotti... | [K; I] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: p120cas (xenopus tropicalis) (aka catenin delta 1)
E: p130cas ... | [G; G] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: p120cas (xenopus tropicalis) (aka catenin delta 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c-x-c motif chemokin... | [A; A] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar3 antisense rna 1 (homo sapiens) (aka bcar3 antisense rna 1)
D: bcar1 (bos taurus) (aka bcar1 scaffold ... | [A; A] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bre... | [E; E] |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: bcar1 scaffold ... | [D] |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E:... | [A] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
D: p120cas (hom... | [B; C] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: p130cas (sus scrofa) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (homo sapiens) ... | [D; I] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas fam... | [B] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
E: None of the above... | [E] |
<Instruct>: Given the context 'BCAR1 transcripts were detected in multiple human tissues and were similar in size to transcripts produced by retrovirus-mutated ZR-75-1 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family ... | [C] |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1 p... | [B] |
<Instruct>: Given the context 'Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1... | [A] |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1 scaffold pr... | [E] |
<Instruct>: Given the context 'Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [langerin]
<Options>: A: cd207 (homo sapiens) (aka cd207 molecule)
B: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
C: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
D: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
E: cd206 (homo sapiens) (aka mannose receptor ... | [A] |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
D: cd207 molecule (homo sapiens) (aka cd207 molec... | [D] |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [langerin]
<Options>: A: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd20l5 (homo sapiens) (aka membra... | [E] |
<Instruct>: Given the context 'Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [langerin]
<Options>: A: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a... | [C] |
<Instruct>: Given the context 'Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd206 (homo sapiens) (aka mannose receptor c-type 1)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
E: cd20l (homo sapiens) (aka membrane span... | [A] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [langerin]
<Options>: A: cd207 (homo sapiens) (aka cd207 molecule)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
D: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
E: cd206 (homo sapiens) (aka mannose receptor c... | [A] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [langerin]
<Options>: A: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
B: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
C: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
D: cd206 (homo sapiens) (aka mannose receptor c-type 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Cloning and characterisation of the Sry-related transcription factor gene Sox8.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (danio rerio) (aka sry-box transcription factor 8b)
B: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
C: sox8 (gallus gallus) (aka sry-box 8)
D: sox8 (sus scrofa) (aka sry-box transcription factor 8)
E: sry-box transcription factor 8 (homo sapiens) (aka sry-box tran... | [E] |
<Instruct>: Given the context 'We report here the isolation of Sox8 and its characterisation in mice and humans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
C: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
D: sox8 (danio rerio) (aka sry-box transcription factor 8b)
E: sox... | [A] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sox10 (danio rerio) (aka sry-box transcription factor 10)
B: sox9-b (xenopus laevis) (sry-box 9 s homeolog (xenopus laevis)) (aka sry-box 9 s homeolog)
C: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
D: sox-10 (gallus gallus) (aka sry-box 10)
E: sox10 (xenopus tropicalis) (... | [G; I] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sox9 promoter region (homo sapiens) (aka sox9 promoter region)
B: sox9 (xenopus laevis) (sry-box 9 l homeolog (xenopus laevis)) (aka sry-box 9 l homeolog)
C: sox10 (gallus gallus) (aka sry-box 10)
D: sox9-b (xenopus laevis) (sry-box 9 s homeolog (xenopus laevis)) (aka sry-box 9 s... | [I; F] |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [sox8]
<Options>: A: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
B: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
C: sox8 (sus scrofa) (aka sry-box transcription factor 8)
D: sox8 (mus musculus) (aka sry (s... | [B] |
<Instruct>: Given the context 'Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [sox8]
<Options>: A: sox8 (sus scrofa) (aka sry-box transcription factor 8)
B: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
C: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E:... | [E] |
<Instruct>: Given the context 'Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [sox8]
<Options>: A: sox8 (danio rerio) (aka sry-box transcription factor 8b)
B: sox8 (sus scrofa) (aka sry-box transcription factor 8)
C: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
D: sox8 (xenopus tropicalis) (aka sry-box 8)
E: sox8 (mus musculus) (aka sry (sex dete... | [C] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus tropicalis) (aka syntaphilin)
B: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
E: sy... | [C] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus tropicalis) (aka syntaphilin)
B: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
C: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: None... | [E] |
<Instruct>: Given the context 'Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [snap-25]
<Options>: A: snap25 (homo sapiens) (aka synaptosome associated protein 25)
B: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
C: snap-25 (xenopus tropicalis) (aka synaptosome associated protein 25kda... | [A] |
<Instruct>: Given the context 'We have cloned and characterized a protein called syntaphilin that is selectively expressed in brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (sus scrofa) (aka syntaphilin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syntaphilin (xenopus ... | [C] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (homo sapiens) (aka syntaphilin)
C: syn1 (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
D: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila mel... | [B; F] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
C: snap-25 (bos taurus) (aka synaptosome associated protein 25)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syntaphilin s homeolog (xenopus... | [A; I] |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: syntaphilin (ho... | [E] |
<Instruct>: Given the context 'Furthermore, introduction of syntaphilin into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (bos taurus) (aka syntaphilin)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (a... | [D] |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
F:... | [D] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: follicle stimulating hormone receptor (rattus norvegicus) (aka follicle stimulating hormone receptor)
B: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
C: follicle stimulating hormone receptor (xenopu... | [E] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
B: follicle stimulating hormone receptor (gallus gallus) (aka follicle stimulating hormone receptor)
C: follicle stimulating hormone receptor (xenopus tr... | [E] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
C: follicle stimulating hormone receptor (sus scrofa) (aka follicle stimu... | [G; G] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
B: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: follicle stimulating ... | [A; A] |
<Instruct>: Given the context 'Epitope mapping using synthetic peptides, and truncated hFSH-R variants revealed that mAb 106.156 bound to ECD residues 183-220, while mAbs 106.318, 106.290, 106.263 bound ECD residues 300-331.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [hfsh-r]
<Options>: A: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
B: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
C: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasin... | [E] |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical co... | <Mentions>: [hfsh-r]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: thyroid stimulating hormone receptor (homo sapiens) (aka thyro... | [B] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
D: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
E:... | [D; E] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: ghr (homo sapiens) (aka growth hormone receptor)
B: neuraminidase 1 (homo sapiens) (aka neuraminidase 1)
C: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
D: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
E: ... | [E; B] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
D: ghr (homo sapiens) (aka growth hormone rec... | [J; G] |
<Instruct>: Given the context 'Thus truncated hFSH-R variants do not reach the medial or trans Golgi where high mannose oligosaccharides are trimmed and sialic acid is added.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [hfsh-r]
<Options>: A: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
C: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
D: thyroid stimulating hormone receptor (homo... | [B] |
<Instruct>: Given the context 'The pro-alpha3(V) collagen chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v) collagen]
<Options>: A: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
D: collagen... | [E] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: collagen type v ... | [B; D] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 ch... | [H; G] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: col... | [H; L; N] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla3a (homo sapiens) (aka integrin subunit alpha 3)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
D: integrin subunit alpha v (homo sapien... | [C; J; B] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
D: integrin subunit alpha v (xenopus tro... | [B; A; H] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [pro-alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
D: collagen type v alpha 3 ch... | [D] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
D... | [B; E; E] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen, type v, alpha 1 s homeolog (xenopus laevis) (aka collagen, type v, alpha 1 s homeolog)
C: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 ... | [F; G; G] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
D: apoa-v (rattus norvegicus) (aka ap... | [H; I; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 3 chain (sus scrofa) (aka colla... | [H; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
D: collagen t... | [I; D] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: vla3a ... | [A; B; G] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v... | [H; K; J] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
D: collagen type xiv alpha 1 chain (ho... | [L; E; C] |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [alpha3(v)]
<Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
D: collagen type v alpha 3 chain (xenopus tropicalis) (aka c... | [F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
B: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
D: integ... | [K; N; L] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
D: col... | [B; J; C] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alp... | [L; F; N] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
D: collagen type v alpha 2 chain (homo sapiens) (aka collagen typ... | [B; L; D] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col5a3.s (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (rattus norvegicus) (aka in... | [I; J; F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
D: col5a3 (sus scrofa) (aka collag... | [B; K; M] |
<Instruct>: Given the context 'COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing linkage with EDS and other disease phenotypes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [col5a3]
<Options>: A: col5a3 (homo sapiens) (aka collagen type v alpha 3 chain)
B: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
C: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
D: col4a3 (homo sapiens) (aka collagen type iv alpha 3 chain)
E: col5a1 (homo sapiens) (aka collagen type ... | [A] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin prote... | [B; F] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: tumor protein p53 (homo sapiens) (aka tumor protein p53)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiqui... | [J; B] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: trp53 (homo sapiens) (aka tumor protein p53)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
E: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute... | [G; B] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: tumor protein p53 (homo sapiens) (aka tumor protein p53)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: rad53 (homo sapiens) (aka che... | [B] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: mdm2 oncogene, e3 ubiquitin protein ... | [E; H] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: tumor protein p73 (homo sapiens) (aka tumor protein p73)
C: mdm2bp (homo sapiens) (aka mdm2 binding protein)
D: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: mdm2, transformed 3t3 c... | [D; I] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: ubiquitin-activating enzyme 1 (arabidopsis thaliana) (aka ubiquitin-act... | [H; I] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: ubiquitin-like modifier-activating enzyme 1 (gallus gallus) (aka ubiquitin-like modifier-activating enzyme 1)
C: ubiquitin-activating enzyme 1 (arabidopsis thaliana) (aka ubiquitin-activating enzyme 1)
D... | [D; H] |
<Instruct>: Given the context 'It is apparent, therefore, that Mdm2 manifests an intrinsic capacity to mediate ubiquitination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2]
<Options>: A: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudog... | [A] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2bp (homo sapiens) (aka mdm2 binding protein)
E: ct53 (homo sapiens) (aka zinc finger protein 165)
F: mdm1 (ho... | [G; A] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
B: mdm2bp (homo sapiens) (aka mdm2 binding protein)
C: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (ak... | [G; C] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: e... | [I; G] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-on... | [C; D] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: praja ring finger ubiquitin ligase 1 (bos taurus) (aka praja ring finger ubiquitin ligase 1)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
D: m... | [G; J] |
<Instruct>: Given the context 'However, this RING was ineffective in ubiquitination and proteasomal targeting of p53, suggesting that there may be specificity at the level of the RING in the recognition of heterologous substrates.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [p53]
<Options>: A: tumor protein p53 (homo sapiens) (aka tumor protein p53)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: rad53 (homo sapiens) (aka che... | [A] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: cd344 (homo sapiens) (aka frizzled class receptor 4)
D: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
E: fat4 (homo ... | [O; M; J] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin like (homo sapiens) (aka podocalyxin like)
B: podocalyxin like (bos taurus) (aka podocalyxin like)
C: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
D: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
E: cd34 (homo sa... | [N; E; A] |
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