instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
B: podocalyxin like (gallus gallus) (aka podocalyxin like)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: podocalyxin like (oryctolagus ... | [K; H; I] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: fat4 (homo sapiens) (aka fat atypical cadherin 4)
B: podocalyxin like (homo sapiens) (aka podocalyxin like)
C: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
D: cd34 (gallus gallus) (aka cd34 molecule)
E: nectin-4 (homo sapiens) (aka ... | [N; O; B] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [podocalyxin]
<Options>: A: podn (homo sapiens) (aka podocan)
B: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
C: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
D: podocalyxin like (homo sapiens) (aka podocalyxin like)
E: podocalyxin like (gallus gallus) (aka podocalyxin like)
F:... | [D] |
<Instruct>: Given the context 'Using homologies present in the cytoplasmic tails of these proteins, we have identified a novel member of this family, which we designate endoglycan.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [endoglycan]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
C: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
D: betaglycan (rattus norvegicus) (aka transforming growth fact... | [A] |
<Instruct>: Given the context 'In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [endoglycan]
<Options>: A: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
B: endomucin (homo sapiens) (aka endomucin)
C: endoglin (homo sapiens) (aka endoglin)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase... | [D] |
<Instruct>: Given the context 'Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: endomucin (homo sapiens) (aka endomucin)
C: endoglin (homo sapiens) (aka endoglin)
D: bgcan (homo sapiens) (aka transforming growth factor beta receptor 3)
E: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
F: None of... | [A] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: podn (homo sapiens) (aka podocan)
B: podocalyxin like (homo sapiens) (aka podocalyxin like)
C: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: podocalyxin like (oryctolagus cuniculus) (aka p... | [C; B; D] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: fat4 (homo sapiens) (aka fat atypical cadherin 4)
B: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
C: endoglin (homo sapiens) (aka endoglin)
D: endomucin (homo sapiens) (aka endomucin)
E: podocalyxin like ... | [O; N; F] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: fat4 (homo sapiens) (aka fat atypical cadherin 4)
B: podocalyxin like (homo sapiens) (aka podocalyxin like)
C: cd34 (sus scrofa) (aka cd34 molecule)
D: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
E: podocalyxin-like (homo sapiens) (aka podoca... | [J; B; O] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
B: endoglin (homo sapiens) (aka endoglin)
C: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
D: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
E:... | [D; I; G] |
<Instruct>: Given the context 'While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [endoglycan]
<Options>: A: endoglin (homo sapiens) (aka endoglin)
B: endomucin (homo sapiens) (aka endomucin)
C: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellu... | [D] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: 8d6 (mus musculus) (aka cd320 antigen)
B: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
C: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
E: eg:8d8.6 (drosophila mel... | [H; H] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: 8d6 (mus musculus) (aka cd320 antigen)
B: 8d6 (homo sapiens) (aka cd320 molecule)
C: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
D: d6 (homo sapiens) (aka atypical chemokine receptor 2)
E: 6c6-ag (homo sapiens) (aka b cell receptor associated prote... | [B; B] |
<Instruct>: Given the context 'The 8D6 Ag is a novel protein of 282 amino acids that is expressed abundantly on FDCs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
B: 8d6a (homo sapiens) (aka cd320 molecule)
C: tspan-6 (homo sapiens) (aka tetraspanin 6)
D: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
E: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltr... | [B] |
<Instruct>: Given the context 'Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
B: 8d6 (mus musculus) (aka cd320 antigen)
C: 8d6a (homo sapiens) (aka cd320 molecule)
D: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
F: Non... | [C] |
<Instruct>: Given the context 'Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
B: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: 8d6 (mus musculus) (aka cd320 antigen)
D: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
E: None of the above. | [E] |
<Instruct>: Given the context 'The mAb 8D6 blocks the costimulatory function completely.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6]
<Options>: A: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
B: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
C: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
D: 8d6a (homo sapiens) (aka cd320 molecule)
E: d8 (homo sapiens) (aka ubiquitin... | [D] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: d8 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
B: cd40 (homo sapiens) (aka cd40 molecule)
C: d6 (homo sapiens) (aka atypical chemokine receptor 2)
D: tnf receptor superfamily member 4 (homo sapiens) (aka tnf receptor superfamily member 4)
E: cd40 (bos taurus) (... | [H; B] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
B: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
C: 8d6 (homo sapiens) (aka cd320 molecule)
D: cd40l (homo sapiens) (aka cd40 ligand)
E: cd40 (bos taurus) (aka cd40 molecule)
F: tnfrsf4 (homo sapie... | [C; I] |
<Instruct>: Given the context 'In addition, the mAb 8D6 inhibits the growth of a lymphoma of GC origin, L3055, which depends on FDCs or HK cells for its growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [8d6]
<Options>: A: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
B: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
C: d6 (homo sapiens) (aka atypical chemokine receptor 2)
D: 8d6a (homo sapiens) (aka cd320 molecule)
E: defa6 (homo sapiens) (aka defensin alpha 6)... | [D] |
<Instruct>: Given the context 'An FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
B: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
C: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
E: 8d6 ... | [E] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: leukosialin-like (rattus norvegicus) (aka leukosialin-like)
B: spn (xenopus tropicalis) (sialophorin (xenopus tropicalis)) (aka sialophorin)
C: cd43 (xenopus tropicalis) (aka sialophorin)
D: cd49c (homo sapiens) (aka integrin subunit alpha 3)
E: cd46 molecule (homo sapiens)... | [F; F] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: granulysin (homo sapiens) (aka granulysin)
B: integrin binding sialoprotein (homo sapiens) (aka integrin binding sialoprotein)
C: sialophorin (sus scrofa) (aka sialophorin)
D: galn (homo sapiens) (aka galanin and gmap prepropeptide)
E: cd49c (homo sapiens) (aka integrin sub... | [I; I] |
<Instruct>: Given the context 'This study analyzed the behavior of an antiadhesive membrane molecule, CD43, in neutrophil polarization and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd43]
<Options>: A: gp3a (homo sapiens) (aka integrin subunit beta 3)
B: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
C: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
D: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | [E] |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [cd43]
<Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: cd43 (homo sapiens) (aka sialophorin)
D: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
E: cd46 molecule (homo sapiens) (aka cd46 molecule)
F: None of the above. | [C] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd1c (homo sapiens) (aka cd1c molecule)
B: itgax (mus musculus) (aka integrin alpha x)
C: cd11b (bos taurus) (aka integrin subunit alpha m)
D: cd11a (homo sapiens) (aka integrin subunit alpha l)
E: cd18 (homo sapiens) (aka integrin subunit beta 2)
F: cd15 (homo sapiens) (aka fuco... | [G; E] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd1c molecule (homo sapiens) (aka cd1c molecule)
B: itgax (mus musculus) (aka integrin alpha x)
C: cd11b (mus musculus) (aka integrin alpha m)
D: mac1a (homo sapiens) (aka integrin subunit alpha m)
E: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
F: cd11b (bos taurus) ... | [D; G] |
<Instruct>: Given the context 'Stimulation of suspended or adherent neutrophils with chemotactic peptide results in cell polarization and locomotion and a concomitant redistribution of CD43 to the uropod.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [cd43]
<Options>: A: cd43 (homo sapiens) (aka sialophorin)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
D: cd43 (xenopus tropicalis) (aka sialophorin)
E: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: None of the above. | [A] |
<Instruct>: Given the context 'The study also investigated which actin-binding protein could be involved in CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd43]
<Options>: A: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
B: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
C: gp3a (homo sapiens) (aka integrin subunit beta 3)
D: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | [E] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
B: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
C: moesin l homeolog (xenopus laevis) (aka moesin l homeolog)
D: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s ho... | [I; F] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
B: actn1 (homo sapiens) (aka actinin alpha 1)
C: moesin l homeolog (xenopus laevis) (aka moesin l homeolog)
D: moesin (homo sapiens) (aka moesin)
E: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
F: moesin s hom... | [B; D] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: moesin (bos taurus) (aka moesin)
D: cd43 (homo sapiens) (aka sialophorin)
E: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: moesin l homeolog (xenopus lae... | [J; D] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: p-moesin (drosophila melanogaster) (aka moesin)
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: moesin (mus musculus) (aka moesin)
D: cd49c (homo sapiens) (aka integrin subunit alpha 3)
E: moesin (homo sapiens) (aka moesin)
F: cd43 (homo sapiens) (aka sialophorin)
G: moe... | [E; F] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
B: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
C: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
D: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
E: actinin alph... | [I; G] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
D: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
E: actinin-4 (homo... | [C; F] |
<Instruct>: Given the context 'These results shed new light on the role of CD43 membrane redistribution, which appears to be directly related to neutrophil polarity and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [cd43]
<Options>: A: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
B: cd46 molecule (homo sapiens) (aka cd46 molecule)
C: cd43 (homo sapiens) (aka sialophorin)
D: gp3a (homo sapiens) (aka integrin subunit beta 3)
E: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
F: None of the above. | [C] |
<Instruct>: Given the context 'Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [kiaa0001]
<Options>: A: eg:eg0001.1 (drosophila melanogaster) (aka pepsinogen c-like)
B: eg:eg0003.1 (drosophila melanogaster) (aka uncharacterized protein)
C: eg:96g10.1 (drosophila melanogaster) (aka pre-intermoult gene 1)
D: heat repeat-containing protein 1 homolog (caenorhabditis elegans) (aka heat rep... | [F] |
<Instruct>: Given the context 'Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [alpha1a voltage-dependent calcium channel]
<Options>: A: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
C: cacna1a (hom... | [C] |
<Instruct>: Given the context 'A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
C: a1a (homo sapiens) (aka serpin family a member 1)
D: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin... | [A] |
<Instruct>: Given the context 'Human alpha1A channels carrying various polyglutamine length with or without NP were expressed in HEK293 cells, and channel properties were compared using a whole-cell voltage clamp technique.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
C: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alp... | [C] |
<Instruct>: Given the context 'alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control.', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
D: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
E:... | [E] |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alp... | <Mentions>: [alpha1a]
<Options>: A: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
B: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
C: a1a (homo sapiens) (aka serpin family a member 1)
D: hemoglobin subunit alpha 1 (homo sapien... | [E] |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [alpha1a]
<Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
D: a1a (homo sapiens) (aka serpin family a member 1)
E: he... | [B] |
<Instruct>: Given the context 'Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six homeobox 2 (homo sapiens) (aka six homeobox 2)
B: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
C: six5 (homo sapiens) (aka six homeobox 5)
D: six4 (homo sapiens) (aka six homeobox 4)
E: six3 (homo sapiens) (aka six homeobox 3... | [A] |
<Instruct>: Given the context 'Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six5 (homo sapiens) (aka six homeobox 5)
B: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
C: six4 (homo sapiens) (aka six homeobox 4)
D: six3 (homo sapiens) (aka six homeobox 3)
E: None of the above. | [E] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: sog (drosophila melanogaster) (aka short gastrulation)
B: soh1 (homo sapiens) (aka mediator complex subunit 31)
C: arctus oculus (drosophila melanogaster) (aka arctus oculus)
D: soo (mus musculus) (aka sooty foot)
E: oculus-parvus (drosophila melanogaster) (aka oculus parvus)... | [F; F] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: quo (homo sapiens) (aka kiaa1755)
B: soho (danio rerio) (aka h6 family homeobox 4)
C: sotos (homo sapiens) (aka nuclear receptor binding set domain protein 1)
D: soo (mus musculus) (aka sooty foot)
E: sog (drosophila melanogaster) (aka short gastrulation)
F: otx (drosophila m... | [G; G] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six5 (mus musculus) (aka sine oculis-related homeobox 5)
B: d-six3 (drosophila melanogaster) (aka optix)
C: six6 (homo sapiens) (aka six homeobox 6)
D: six3 (xenopus tropicalis) (aka six homeobox 3)
E: six4/5 (drosophila melanogaster) (aka six4)
F: six6 (xenopus tropicalis) ... | [K; C; G] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
B: six3 (xenopus tropicalis) (aka six homeobox 3)
C: hairy and enhancer of split 5 gene 5 (xenopus tropicalis) (aka hairy and enhancer of split 5 gene 5)
D: six homeobox 3 (homo s... | [M; G; D] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
B: six homeobox 3 (homo sapiens) (aka six homeobox 3)
C: six3 (gallus gallus) (aka six homeobox 3)
D: paired box protein 6 homolog (caenorhabditis elegans) (aka paired box protein... | [F; M; B] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six6 (xenopus laevis) (aka six homeobox 6 l homeolog)
B: six3 (xenopus laevis) (six homeobox 3 s homeolog (xenopus laevis)) (aka six homeobox 3 s homeolog)
C: six5 (mus musculus) (aka sine oculis-related homeobox 5)
D: six5 (homo sapiens) (aka six homeobox 5)
E: enhancer of ... | [F; G; M] |
<Instruct>: Given the context 'We have cloned and characterised the gene that encodes human SIX2, elucidated its gene structure and conducted expression studies in a range of tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [six2]
<Options>: A: six2 (xenopus tropicalis) (aka six homeobox 2)
B: six2 (mus musculus) (aka sine oculis-related homeobox 2)
C: six6 (homo sapiens) (aka six homeobox 6)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six2 (homo sapiens) (aka six homeobox 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'SIX2 is widely expressed in the late first-trimester fetus, but has a limited range of expression sites in the adult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six2 (homo sapiens) (aka six homeobox 2)
B: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
C: six2 (gallus gallus) (aka six homeobox 2)
D: six3 (homo sapiens) (aka six homeobox 3)
E: six2 (xenopus tropicalis) (aka six homeobox 2)
F... | [A] |
<Instruct>: Given the context 'The expression pattern of SIX2 and its localisation to chromosome 2p15-p16 will be of use in assessing its candidacy in human developmental disorders.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [six2]
<Options>: A: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
B: six4 (homo sapiens) (aka six homeobox 4)
C: six2 (xenopus tropicalis) (aka six homeobox 2)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six homeobox 2 (homo sapiens) (aka six home... | [E] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pro-trh (homo sapiens) (aka thyrotropin releasing hormone)
B: parathymosin-like (homo sapiens) (aka parathymosin-like)
C: pth (homo sapiens) (parathyroid hormone (homo sapiens)) (aka parathyroid hormone)
D: parathyroid hormone (... | [J; J; J] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthrp (bos taurus) (aka parathyroid hor... | [I; I; I] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: hptp (homo... | [C; C; C] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
B: hpt (homo sapiens) (aka hypoparathyroidism)
C: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: parathyroid hormone (homo sapiens) (aka parat... | [D; H] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: trhr (homo sapiens) (aka thyrotropin releasing hormone receptor)
C: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
E: pthr (homo s... | [G; H] |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pthrp]
<Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthrp (homo sapiens) (aka parathyroid... | [E] |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E: None of the above. | [E] |
<Instruct>: Given the context 'Although initially discovered in malignancies, PTHrP is now known to be produced by most cells and tissues in the body.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
E: pthr1 (homo sapiens) (aka parath... | [D] |
<Instruct>: Given the context 'It acts as an autocrine and paracrine mediator of cell proliferation and differentiation, effects which are mediated via the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [pth/pthrp receptor]
<Options>: A: trhr (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
C: pth1r (homo sapiens) (aka parathyroid hormone 1 receptor)
D: parathyroid hormone 2 receptor (homo sapiens) (aka parathyro... | [C] |
<Instruct>: Given the context 'Recent evidence also has shown that, directly after translation, PTHrP is able to enter the nucleus and/or nucleolus and influence cell cycle progression and apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pthrp]
<Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
E: pthrp (xenopus laevis) (aka para... | [C] |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: pthrp (bos taurus) (aka parathyroid hormone li... | [C] |
<Instruct>: Given the context 'Overexpression of PTHrP was associated with an increase in mitogenesis, whereas inhibiting endogenous PTHrP production resulted in decreased cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [pthrp]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
E: parathyroid hormone like hormone (hom... | [E] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
D: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)... | [F; I] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: trhr (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: pth promoter region (homo sapiens) (aka pth promoter region... | [G; H] |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pthrp]
<Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
D: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone... | [D] |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E: None of the above. | [E] |
<Instruct>: Given the context 'Furthermore, neutralization of added peptide with an anti-PTHrP antiserum completely abolished the growth inhibitory effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
E: pthrp (... | [B] |
<Instruct>: Given the context 'In contrast, this antibody has no effect on the increased proliferation rate of the MCF-7 transfectants that overexpress PTHrP, compared with control cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone... | [D] |
<Instruct>: Given the context 'The net effect of autocrine/paracrine and intracrine effects of PTHrP in MCF-7 cells overproducing the peptide is accelerated cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [pthrp]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthrp (... | [C] |
<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
C: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E... | [B] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
B: selectin-e (homo sapiens) (aka selectin e)
C: cd62 (homo sapiens) (aka selectin p)
D: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
E: selectin p ligand (sus scrofa) (aka select... | [H; H] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: selectin p ligand (sus scrofa) (aka selectin p ligand)
B: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
C: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
D: selectin e (homo sapiens) (aka selectin e)
E: psg4 (homo sapiens) ... | [G; G] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selp (homo sapiens) (selectin p (homo sapiens)) (aka selectin p)
B: selectin p (homo sapiens) (aka selectin p)
C: selectin p (sus scrofa) (aka selectin p)
D: selectin e (homo sapiens) (aka selectin e)
E: psg4 (homo sapiens) (aka pregnancy sp... | [A; F; F] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin p ligand (homo sapiens) (aka selectin p ligand)
B: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
C: selectin e (homo sapiens) (aka selectin e)
D: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (ho... | [G; A; A] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
B: selectin e (homo sapiens) (aka selectin e)
C: selectin p (sus scrofa) (aka selectin p)
D: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
E: selectin p... | [K; H; H] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: alpha1,6-fucosyltransferase (drosophila melanogaster) (aka alpha1,6-fucosyltransferase)
B: alpha(1,3)fucosyltransferase gene 1 (danio rerio) (aka alpha(1,3)fucosyltransferase gene 1)
C: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycop... | [F; G; G] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: fucosyltransferase 10 (alpha (1,3) fucosyltransferase) (xenopus tropicalis) (aka fucosyltransferase 10 (alpha (1,3) fucosyltransferase))
B: fuc-tvii (bos taurus) (aka fucosyltransferase 7)
C: alpha(1,3)fucosyltransferase gene 1 (danio rerio) (... | [N; L; L] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
B: 3-fuct (drosophila melanogaster) (aka alpha1,3-fucosyltransferase a)
C: fuct-vi (homo sapiens) (aka fucosyltransferase 6)
D: psgl1 (homo sapiens) (aka selectin p ligand)
E: ... | [D; E; E] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: alpha(1,3)fucosyltransferase gene 1 (danio rerio) (aka alpha(1,3)fucosyltransferase gene 1)
B: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
C: alpha-(1,3)-fucosylt... | [D; K; K] |
<Instruct>: Given the context 'Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [psgl-1]
<Options>: A: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 5)
B: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
C: psgl-1 (homo sapiens) (aka selectin p ligand)
D: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
E: psg1 (homo sapiens) (pregnanc... | [C] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: mp (mus musculus) (aka micropinna microphthalmia)
B: aag (mus musculus) (n-methylpurine-dna glycosylase (mus musculus)) (aka n-methylpurine-dna glycosylase)
C: ppg (mus musculus) (aka glucagon)
D: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguan... | [H; H] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: n-methylpurine-dna glycosylase (mus musculus) (aka n-methylpurine-dna glycosylase)
B: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
C: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
D: 8-oxoguanine dna-glycosy... | [C; C] |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: mpg-1 (homo sapiens) (aka macrophage expressed 1)
B: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
C: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
D: 8-oxoguanine dna-glycosylase 1 (mus musculus) (aka 8-oxog... | [C; C] |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: 8-oxoguanine dna glycosylase (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: dna-3-methyladenine glycosylase 1-like (glycine max) (aka dna-3-methyladenine gl... | [E; E] |
<Instruct>: Given the context 'In comparison, homologues of the Rad23 proteins (hHR23) and the hXPC protein are involved in the recognition of damaged bases in global genome repair, a subset of nucleotide excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hxpc]
<Options>: A: hcypx (homo sapiens) (aka peptidylprolyl isomerase like 1)
B: humpcp (homo sapiens) (aka prolylcarboxypeptidase)
C: hpcx (homo sapiens) (aka hereditary prostate cancer, x-linked)
D: hcph (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 6)
E: hppc (homo sapiens) (aka al... | [F] |
<Instruct>: Given the context 'In this report, we show that the hHR23A and -B also interact with the MPG protein and can serve as accessory proteins for DNA damage recognition in base excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [mpg]
<Options>: A: ppg (mus musculus) (aka glucagon)
B: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
C: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
D: mgp (mus musculus) (aka matrix gla protein)
E: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Furthermore, the MPG.hHR23 protein complex elevates the rate of MPG protein-catalyzed excision from hypoxanthine-containing substrates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [mpg]
<Options>: A: mpg-1 (homo sapiens) (aka macrophage expressed 1)
B: mgp (homo sapiens) (aka matrix gla protein)
C: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
D: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
E: ppg (mus musculus) (aka glucagon)
F: None of the above. | [C] |
<Instruct>: Given the context 'This increased excision rate is correlated with a greater binding affinity of the MPG protein-hHR23 protein complex for damaged DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mpg]
<Options>: A: mgp (mus musculus) (aka matrix gla protein)
B: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
C: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
D: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
E: mpg-1 (homo sapiens) (aka macrophage expressed 1)
F: Non... | [C] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: omt (drosophila melanogaster) (aka rab1)
B: htr2 (homo sapiens) (aka 5-hydroxytryptamine receptor 2a)
C: htra serine peptidase 1 (homo sapiens) (aka htra serine peptidase 1)
D: htra serine peptidase 2 (homo sapiens) (aka htra serine peptidase 2)
E: htra serine peptidase ... | [D; D; D] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: htra serine peptidase 2 (mus musculus) (aka htra serine peptidase 2)
B: ommatidialess (drosophila melanogaster) (aka ommatidialess)
C: om (mus musculus) (aka ovum mutant)
D: atoh2 (homo sapiens) (aka neuronal differentiation 6)
E: tra2a (homo sapiens) (aka transformer 2 ... | [L; L; L] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: om (mus musculus) (aka ovum mutant)
B: htpcr2 (homo sapiens) (aka olfactory receptor family 7 subfamily a member 5)
C: htra serine peptidase 1 (homo sapiens) (aka htra serine peptidase 1)
D: htra serine peptidase 2 (mus musculus) (aka htra serine peptidase 2)
E: omi (mus... | [I; I; I] |
<Instruct>: Given the context 'In this report we describe the overexpression of humHtrA2 in two heterologous systems comparing the merits of each.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humhtra2]
<Options>: A: hthtr2 (homo sapiens) (aka solute carrier family 19 member 3)
B: ear2 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 6)
C: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: mxra2 (homo sapiens) (aka... | [F] |
<Instruct>: Given the context 'By means of fluorescently labeled substrates alpha- and beta-casein and zymography, the proteolytic activity of recombinant HumHtrA2 was also demonstrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [humhtra2]
<Options>: A: htpcr2 (homo sapiens) (aka olfactory receptor family 7 subfamily a member 5)
B: ear2 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 6)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: ato... | [F] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: interleukin 2 (homo sapiens) (aka interleukin 2)
E: putative mul... | [D; A] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
B: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
C: snft (homo sapiens) (aka basic leucine zipper atf-like transc... | [G; C] |
<Instruct>: Given the context 'The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [il-2]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: il2 (homo sapiens) (aka interleukin 2)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
E: il22 (homo sapiens) (aka interleukin 22)
F: None of the above. | [B] |
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