instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: tall2 (homo sapiens) (aka tnf superfamily member 13)
C: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
D: cd95-l (homo sapiens) (aka fas ligand)
E: a... | [I; A; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: cd95l (homo sapiens) (aka fas ligand)
C: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
D: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threon... | [I; N; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
D: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (a... | [P; I; E] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo-2l (homo sapiens) (aka tnf superfamily member 10)
B: tall-2 (homo sapiens) (aka tnf superfamily member 13)
C: fasas (homo sapiens) (aka fas antisense rna 1)
D: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonin... | [P; O; A] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
B: apof (homo sapiens) (aka apolipoprotein f)
C: fasas (homo sapiens) (aka fas antisense rna 1)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: apo-2l (homo sapiens) (aka tnf superfamily member 1... | [P; O; E] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fasas (homo sapiens) (aka fas antisense rna 1)
B: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
E: apo2l (homo sapiens... | [E; B; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
B: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: fas-as (homo sapiens)... | [H; N; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: cd951 (homo sapiens) (aka fas cell surface death receptor)
B: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
C: apol-i (homo sapiens) (aka apolipoprotein l1)
D: fas-as (homo sapiens) (aka fas antisense rna 1)
E: apo3l (homo sapiens) (aka tnf superfamily memb... | [I; N; P] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
C: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
D: fas ligand ... | [C; C; G] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: tall-2 (homo sapiens) (aka tnf superfamily member 13)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
E: cd40 ligand (homo sapiens) (aka cd40 lig... | [I; I; M] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: cd40 ligand (homo sapiens) (aka cd40 ligand)
C: fas ligand (homo sapiens) (aka fas ligand)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: cd... | [A; A; N] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: cd40 ligand (homo sapiens) (aka cd40 ligand)
B: fas-as (homo sapiens) (aka fas antisense rna 1)
C: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
D: cd95-l (homo sapiens) (aka fas ligand)
E: fas cell surface death receptor (homo sapiens) (aka fas cell surfac... | [E; E; G] |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [polypeptide n-acetylgalactosaminyltransferase, galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalac... | [B] |
<Instruct>: Given the context 'Here we report the cDNA cloning and expression of a novel GalNAc-transferase termed GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: udp-n-acetyl-alpha-d-galactosamine:... | [D] |
<Instruct>: Given the context 'The overall amino acid sequence similarity with GalNAc-T1 and -T2 is approximately 45%; 12 cysteine residues that are shared between GalNAc-T1 and -T2 are also found in GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide ... | [C] |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the cor... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
B: galnac-t3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (drosophil... | [B] |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the cor... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypep... | [E] |
<Instruct>: Given the context 'Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosam... | [D] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-5)
C: e... | [A; A; A] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation init... | [A; A; A] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila me... | [A; A; A] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryoti... | [I; I; I] |
<Instruct>: Given the context 'In this paper, the multiple mRNAs that encode mammalian eIF-5 have been characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) ... | [E] |
<Instruct>: Given the context 'In rat tissues, three major eIF-5 mRNAs of 3.5, 2.8, and 2.2 kilobases in length are detected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor 5 (xenopus t... | [D] |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept for each mention using the provid... | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor 5 (xenopus t... | [D] |
<Instruct>: Given the context 'The different lengths of the 3'-untranslated region of eIF-5 mRNAs are generated by the use of alternative polyadenylation signals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [eif-5]
<Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translatio... | [E] |
<Instruct>: Given the context 'Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation ini... | [C] |
<Instruct>: Given the context 'These results should lead to increased understanding of the regulation of eIF-5 gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
D: translatio... | [B] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: granzyme b, pseudogene 2 (rattus norvegicus) (aka granzyme b, pseudogene 2)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: granzyme b (mus musculus) (aka granzyme b)
F: granzyme... | [C; F] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: granzyme b (rattus norvegicus) (aka granzyme b)
C: granzyme b-like (rattus norvegicus) (aka granzyme b-like)
D: caspase 6 (homo sapiens) (aka caspase 6)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: ice-lap3 (homo sapiens)... | [E; G] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: granzyme b (oryctolagus cuniculus) (aka granzyme b)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: ice-lap3 (homo sapiens) (aka caspase 7)
D: granzyme b-like (rattus norvegicus) (aka granzyme b-like)
E: granzyme b (rattus norvegicus) (aka granzyme b)
F: ice-lap6 (xenopus ... | [B; J] |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: ice-lap3 (homo sapiens) (aka caspase 7)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: caspase-6 (homo sapiens) (aka caspase 6)
F: None of the above. | [B] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: cuta (homo sapiens) (aka cuta divalent cation tolerance homolog)
C: apopain (xenopus laevis) (aka caspase 3, gene 2 l homeolog)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: cuta (sus scrofa) (aka cuta divalent c... | [K; O; O; O] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: apop (homo sapiens) (aka cytochrome c oxidase assembly factor 8)
C: pp32 (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
D: sp32 (homo sapiens) (aka acrosin binding protein)
E: apopain (xenopus tr... | [T; F; F; F] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: hcp32 (homo sapiens) (aka cycs pseudogene 32)
B: caspase 6 (homo sapiens) (aka caspase 6)
C: apop1 (drosophila melanogaster) (aka cytochrome c oxidase assembly factor 8)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: chica (homo sapiens) (aka family w... | [P; M; M; M] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: apopain (xenopus laevis) (aka caspase 3, gene 2 l homeolog)
B: csp32 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: cpp32 (homo sapiens) (aka caspase 3)
D: cuta (sus scrofa) (aka cuta divalent cati... | [R; C; C; C] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: hcam-1 (homo sapiens) (aka phosphodiesterase 1a)
B: mcp3 (homo sapiens) (aka c-c motif chemokine ligand 7)
C: casp-7 (homo sapiens) (aka caspase 7)
D: hmcn2 (homo sapiens) (aka hemicentin 2)
E: cmya1 (homo sapiens) (aka xin actin binding repeat containing 1)
F: ca... | [R; C; C; C] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: mcp3 (homo sapiens) (aka c-c motif chemokine ligand 7)
B: caspase 3 (homo sapiens) (aka caspase 3)
C: ice-lap3 (xenopus tropicalis) (aka caspase 7)
D: casp3 (homo sapiens) (aka caspase 3)
E: caspase 3 (drosophila melanogaster) (death related ice-like caspase (dros... | [R; O; O; O] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: casp3 (homo sapiens) (aka caspase 3)
C: mch4 (homo sapiens) (aka caspase 10)
D: cmg-1 (homo sapiens) (aka intraflagellar transport 74)
E: mch2 (mus musculus) (aka caspase 6)
F: caspase 3 (drosophila melanogaster) (death rel... | [R; A; A; A] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: cmya1 (homo sapiens) (aka xin actin binding repeat containing 1)
B: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
C: melanin concentrating hormone receptor 2 (homo sapiens) (aka ... | [R; H; H; H] |
<Instruct>: Given the context 'Interestingly, ICE-LAP6 contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [ice-lap6]
<Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: casp-8 (homo sapiens) (aka caspase 8)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | [E] |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: caspase 6 (homo sapiens) (aka caspase 6)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: casp-8 (homo sapiens) (aka caspase 8)
F: None of the above. | [A] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: casp6 (homo sapiens) (aka caspase 6)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: granzyme b (rattus norvegicus) (aka granzyme b)
E: granzyme b (homo sapiens) (aka granzyme b)
F: granzyme b (oryctolagus cuniculus) (aka granzyme b... | [H; E] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: granzyme b (oryctolagus cuniculus) (aka granzyme b)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: granzyme b, pseudogene 2 (rattus norvegicus) (aka granzyme b, pseudogene 2)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: casp-7 (homo sapiens) (aka caspase... | [G; H] |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [ice-lap6]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: ice-lap3 (homo sapiens) (aka caspase 7)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | [E] |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [ice-lap6]
<Options>: A: ice-lap3 (homo sapiens) (aka caspase 7)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: None of the above. | [E] |
<Instruct>: Given the context 'Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: ... | [F] |
<Instruct>: Given the context 'We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mcb2]
<Options>: A: bmch2 (mus musculus) (aka bone mechanical trait 2)
B: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
C: bmc2 (mus musculus) (aka bone mineral content 2)
D: mc2 (homo sapiens) (aka melanocortin 5 receptor)
E: mbc2 (mus musculus) (aka extended s... | [F] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2... | [E; E] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: cgb2 (homo sapiens) (aka chorionic gonadotropin subunit beta 2)
E: hcn2 (... | [I; I] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
B: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
C: mc2 (homo sapiens) (aka melanocortin 5 receptor)
D: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucl... | [N; N; K] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: bmc2 (mus musculus) (aka bone mineral content 2)
D: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
E: cb1r (homo sapien... | [N; N; E] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
B: bmc2 (mus musculus) (aka bone mineral content 2)
C: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
D: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, ... | [N; N; H] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
B: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
C: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
D: cbc2 (homo sapiens) (aka nuclear cap binding protein ... | [K; K] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
B: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
C: bmc2 (mus musculus) (aka bone mineral content 2)
D: mbc2 (mus musculus) (aka extended sy... | [K; K] |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: cb1r (mus musculus) (aka cannabinoid receptor 1)
C: cb1 (homo sapiens) (aka cannabinoid receptor 1)
D: None of the above. | [C] |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: cb1r (mus musculus) (aka cannabinoid receptor 1)
C: None of the above. | [C] |
<Instruct>: Given the context 'The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [glycine receptor beta]
<Options>: A: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: glycine receptor, beta (rattus norvegicus) (aka glycin... | [A] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
B: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
C: glycine r... | [I; I; C] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glycine receptor beta (bos taurus) (aka glycine receptor beta)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subuni... | [B; B; L] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
C: glyr-a1 (xenopus laevis) (glycine receptor al... | [J; J; D] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: glycine receptor beta (sus scrofa) (aka glycine receptor bet... | [B; B; M] |
<Instruct>: Given the context 'Neither [3H]strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [glyr beta]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
C: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
D: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
E: ... | [E] |
<Instruct>: Given the context 'However, co-expression of the beta subunit cDNA with the alpha 1 subunit cDNA resulted in expression of functional GlyRs which showed a 4-fold reduction in the EC50 values when compared to alpha 1 homomeric GlyRs.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [alpha 1 homomeric glyrs]
<Options>: A: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
B: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
C: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
D: glycine recep... | [A] |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept for each men... | <Mentions>: [alpha 1 glyrs]
<Options>: A: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
C: gpr1as (homo sapiens) (aka cmklr2 antisense rna)
D: glycine receptor alpha 1 (s... | [A] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: gl-r (homo sapiens) (aka glucagon receptor)
C: glrb (homo sapiens) (aka glycine receptor beta)
D: glrb (mus musculus) (aka glycine receptor, beta subunit)
E: glrb (rattus norvegicus) (aka glycine receptor, bet... | [C; C] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: glrb (sus scrofa) (aka glycine receptor beta)
C: glr (homo sapiens) (aka glycine receptor alpha 2)
D: glrb (xenopus tropicalis) (aka glycine receptor beta)
E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseu... | [G; G] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glrb (xenopus tropicalis) (aka glycine receptor beta)
B: glrb (bos taurus) (aka glycine receptor beta)
C: glrb (sus scrofa) (aka glycine receptor beta)
D: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
E: hyperreflexia (homo sapiens) (aka hyperreflexia)
F:... | [H; F; F] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
B: glrb (mus musculus) (aka glycine receptor, beta subunit)
C: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
D: glrb (bos taurus) (aka glycin... | [N; B; B] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glrb (mus musculus) (aka glycine receptor, beta subunit)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: hyperreflexia (homo sapiens) (aka hyperreflexia)
D: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
E: gprg1b (homo sapien... | [N; A; A] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: spastic paraplegia 16 (complicated, x-linked recessive) (homo sapiens) (aka spastic paraplegia 16 (complicated, x-linked recessive))
B: glrb (sus scrofa) (aka glycine receptor beta)
C: spn-4 (caenorhabditis elegans) (aka rrm domain-containing protein)
D: receptor for... | [I; K; K] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [spa]
<Options>: A: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
B: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
C: spam (homo sapiens) (aka eyes shut homolog)
D: spast.s (xenopus laevis) (aka spastin s homeolog)
E: spap (homo sapiens) (aka pdzk1 interac... | [F] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: spa (homo sapiens) (aka surfactant protein a1)
B: glycine receptor beta (bos taurus) (aka glycine receptor beta)
C: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
D: spap1a (homo sapiens) (aka fc receptor like 2)
E: glyr1 (homo sapiens) (aka glyoxylate reduct... | [K; K] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: spap1a (homo sapiens) (aka fc receptor like 2)
E: glrb (ho... | [K; K] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
B: cdc6 (homo sapiens) (aka cell division cycle 6)
C: minichromosome maintenance 5 (drosophila melanogaster) (aka minichromosome maintenance 5)
D: minichromosome maintenance complex component 5 (mus muscu... | [H; H; H] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: mcm5 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cdc6 (homo sapiens) (aka cell division cycle 6)
D: cdc5 (homo sapiens) (aka cell division cycle 5 like)
E: hcp... | [B; B; B] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
B: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
C: p1-cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cdc6 (homo sapiens) (aka cell divisi... | [C; C; C] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna replication licensing factor mcm-5)
B: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
C: cell division cycle 26 (homo sapiens) (aka cell ... | [M; M; M] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
B: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
C: p1-cdc46 (homo sapiens) (aka minichromosome maintenance complex component ... | [F; F] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: cdc5 (homo sapiens) (aka cell division cycle 5 like)
B: minichromosome maintenance complex component 5 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: mcm5 (drosophila melanogaster... | [I; I] |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cdc46]
<Options>: A: cdc16 (homo sapiens) (aka cell division cycle 16)
B: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
C: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
D: p1-cdc46 (homo sapiens) (aka ... | [D] |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [hcdc46]
<Options>: A: ccdc46 (homo sapiens) (aka centrosomal protein 112)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cdc26 (homo sapiens) (aka cell division cycle 26)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: cdc36 (homo sapiens) (aka ccr4-not transcriptio... | [B] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: chmp3 (mus musculus) (aka charged multivesicular body protein 3)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: p1.1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 7)
D: p1-mcm3 (homo sapiens) (aka minichromosome maintena... | [B; D] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: p1.1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: hcp26 (homo sapiens) (aka cycs pseudogene 26)
C: p1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: cdc36 (homo sap... | [G; C] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: cnnm3 (mus musculus) (aka cyclin m3)
B: hcp26 (homo sapiens) (aka cycs pseudogene 26)
C: mcm3 (xenopus tropicalis) (putative ortholog of dna replication licensing factor mcm3 (xenopus tropicalis)) (aka putative ortholog of dna replication licensing factor mcm3)
D: p1 (mus musc... | [G; J] |
<Instruct>: Given the context 'We report herein the presence of kappa opioid receptors (KORs) in human fetal microglia and inhibition of HIV-1 expression in acutely infected microglial cell cultures treated with KOR ligands.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [kor]
<Options>: A: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: oprk (homo sapiens) (aka opioid receptor kappa 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: oprk1 (rattus norvegicus) (aka opioid recep... | [C] |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the cor... | <Mentions>: [kor]
<Options>: A: kor-1 (homo sapiens) (aka opioid receptor kappa 1)
B: kor (mus musculus) (aka opioid receptor, kappa 1)
C: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
D: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: kor-3 (homo sapiens) (aka opioid related nocicepti... | [A] |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [kor]
<Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: oprk (homo sapiens) (aka opioid receptor kappa 1)
C: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: kor-3 (rattus norvegicus) (aka opioid related nocicepti... | [B] |
<Instruct>: Given the context 'This antiviral effect of the kappa ligands was blocked by the specific KOR antagonist, nor-binaltrophimine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kor]
<Options>: A: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
C: oprk (homo sapiens) (aka opioid receptor kappa 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: kor-3 (rattus norvegicus) (aka opioid related nocicepti... | [C] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
B: drada2 (homo sapiens) (aka adenosine deaminase rna specific b1)
C: hp55 (homo sapiens) (aka ... | [N; N; N] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
B: p97 (homo sapiens) (valosin containing protein (homo sapie... | [L; L; L] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: rad51 associated protein 2 (homo sapiens) (aka rad51 associated protein 2)
B: tram2 (homo sapiens) (aka translocation associated membrane protein 2)
C: p97 (drosophila melanogaster) (regulato... | [N; N; N] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: inositol 1,4,5-triphosphate receptor associated 2 (homo sapiens) (aka inositol 1,4,5-triphosphate receptor associated 2)
B: receptor accessory protein 2 (homo sapiens) (aka receptor accessory... | [J; J; J] |
<Instruct>: Given the context 'Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of 4.94.', select the correct biomedical concept for e... | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
C: p97 (drosophila melanogaster) (regulatory particle non-atp... | [A] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, ... | [C; C] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: tra1p2 (homo sapiens) (aka heat shock protein 90 beta family member 3, pseudogene)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: receptor accessory protein 2 (... | [D; D] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
B: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
C: atp synthase membrane subunit c locus 1 (homo sapiens) (aka atp... | [N; J; J] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: p97 (bos taurus) (aka valosin containing protein)
C: map97 (homo sapiens) (aka melanotransferrin)
D: matrix non-peptidase homolog 1 (caenorhabditis elegans) (aka matrix non-... | [M; F; F] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: nonu-1 (caenorhabditis elegans) (aka smr domain-containing protein)
D: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle ba... | [K; D; D] |
<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [nas1]
<Options>: A: nars1 (homo sapiens) (aka asparaginyl-trna synthetase 1)
B: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
C: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
D: anorexia nervosa, s... | [C] |
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