instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor]
<Options>: A: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
B: nk-3r (homo sapiens) (aka tachykinin receptor 3)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
E: nk3r (mus musculus) (aka tac... | [B] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
B: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
C: tachykinin receptor 3 (homo sapiens) (aka tachykinin receptor 3)
D: nkr-p1a (homo sapiens) (a... | [C; O; B; B] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
B: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
C: neuromedin b (rattus norvegicus) (aka neuromedin b)
D: nk3r (mus musculus) (aka tachykinin receptor 3... | [O; E; P; P] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 3 (rattus norvegicus) (aka tachykinin precursor 3)
B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: tachykinin precursor 1 (homo sapiens) (aka tachyk... | [M; L; D; D] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4)
B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3)
D: tachykinin receptor 3 (homo sapiens... | [D; M; G; G] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [neurokinin b]
<Options>: A: neuromedin b (bos taurus) (aka neuromedin b)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: nkb (sus scrofa) (aka tachykinin precursor 3)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
F: Non... | [B] |
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin b]
<Options>: A: neuromedin b (homo sapiens) (aka neuromedin b)
B: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
C: neuromedin b (rattus norvegicus) (aka neuromedin b)
D: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
E... | [E] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nk-3r (homo sapiens) (aka tachykinin receptor 3)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: nkb (homo sapiens) (aka tachykinin precursor 3)
D: nkb (sus scrofa) (aka tachykinin precursor 3)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyr... | [A; C; K] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
C: nknb (homo sapiens) (aka tachykinin precursor 3)
D: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kin... | [H; C; I] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nkb (homo sapiens) (aka tachykinin precursor 3)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
D: neuromedin b (bos taurus) (aka neuromedin b)
E: nkna (xenopus tropi... | [K; A; F] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [substance p]
<Options>: A: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
B: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
C: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1)
D: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
E: tac... | [B] |
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept for ... | <Mentions>: [nk-3 receptor]
<Options>: A: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
B: nk3r (mus musculus) (aka tachykinin receptor 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: nk3r (homo sapiens) (aka tachykinin receptor 3)
E: nk2r (homo sapiens) (aka tac... | [D] |
<Instruct>: Given the context 'Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-type natriuretic peptide]
<Options>: A: c-type natriuretic peptide 1 (gallus gallus) (aka c-type natriuretic peptide 1)
B: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like)
C: natriuretic peptide c (xenopus tropicalis) (aka natriuretic peptide c)
D: natriuretic pe... | [E] |
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [c-type natriuretic peptide; cnp]
<Options>: A: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c)
B: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like)
C: natriuretic peptide a (homo sapiens) (aka natriuretic peptide a)
D: natriuret... | [A; A] |
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [c-type natriuretic peptide; cnp]
<Options>: A: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c)
B: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c)
C: natriuretic peptide c (gallus gallus) (aka natriuretic peptide c)
D: n... | [A; A] |
<Instruct>: Given the context 'Several positive clones with specific binding abilities were obtained, and one was identical as TSC-22, a speculated transcriptional modulator stimulated by transforming growth factor beta (TGF-beta) of unknown function.', select the correct biomedical concept for each mention using the p... | <Mentions>: [tsc-22]
<Options>: A: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
B: tsc-22 (drosophila melanogaster) (aka bunched)
C: tsc-22 (xenopus tropicalis) (aka tsc22 domain family member 1)
D: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
E: tsc-22r (homo sapiens) (aka tsc22 domain family m... | [D] |
<Instruct>: Given the context 'Several positive clones with specific binding abilities were obtained, and one was identical as TSC-22, a speculated transcriptional modulator stimulated by transforming growth factor beta (TGF-beta) of unknown function.', select the correct biomedical concept for each mention using the p... | <Mentions>: [tsc-22]
<Options>: A: tsc-22 (drosophila melanogaster) (aka bunched)
B: tsc-22 (xenopus tropicalis) (aka tsc22 domain family member 1)
C: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
D: tsc-22r (homo sapiens) (aka tsc22 domain family member 3)
E: None of the above. | [E] |
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22r (homo sapiens) (aka tsc22 domain family member 3)
B: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1)
C: cnp (xenopus laevis) (natriuretic peptide c s homeolog (xenopus laevis)) (aka natriuretic peptide c s homeolog)
D: tsc24 (homo sapiens) (aka testis expre... | [E; I] |
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22r (homo sapiens) (aka tsc22 domain family member 3)
B: tsc-22 (drosophila melanogaster) (aka bunched)
C: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l homeolog)
D: tsc complex subunit 2 (homo sapiens) (aka tsc complex ... | [G; F] |
<Instruct>: Given the context 'We further cloned a 1.8-kb full-length human TSC-22 cDNA from a fetal kidney cDNA library by a combination of polymerase chain reaction and the rapid amplification of the cDNA ends technique.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [tsc-22]
<Options>: A: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1)
B: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
C: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4)
D: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
E: tsc complex subun... | [D] |
<Instruct>: Given the context 'In adults, human TSC-22 mRNA was highly expressed in brain, lung and heart.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22]
<Options>: A: tsc-22r (homo sapiens) (aka tsc22 domain family member 3)
B: tsc-22 (xenopus tropicalis) (aka tsc22 domain family member 1)
C: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
D: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
E: tsc24 (homo sapiens) (aka testis expre... | [D] |
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc24 (homo sapiens) (aka testis expressed 35)
B: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l homeolog)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: cnp (xenopus laevis) (natriuretic peptide c s homeolog (... | [C; I] |
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
B: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c)
C: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3)
D: c-type natriuretic peptide-like (xenopus tropi... | [A; F] |
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [tsc-22; cnp]
<Options>: A: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase)
B: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like)
C: tsc-22 (drosophila melanogaster) (aka bunched... | [J; D] |
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [tsc-22; cnp]
<Options>: A: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c)
B: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l homeolog)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: cnp-3 (caenorhabd... | [C; A] |
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
B: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1)
C: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like)
D: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (ak... | [A; D] |
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8; d8s2298e]
<Options>: A: rep8 (homo sapiens) (aka ubx domain protein 8)
B: rep15 (homo sapiens) (aka rab15 effector protein)
C: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
D: rep-8 (mus musculus) (aka ubx domain protein 8)
E: rep8 (xenopus laevis) (aka ubx domain prot... | [A; A] |
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8; d8s2298e]
<Options>: A: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
B: rep8 (homo sapiens) (aka ubx domain protein 8)
C: d17s978e (homo sapiens) (aka cell division cycle 27)
D: s8e (drosophila melanogaster) (aka ribosomal protein s8)
E: rep8 (xenopus tropicalis) (aka ubx domain prote... | [B; B] |
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [rep-8; d8s2298e]
<Options>: A: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
B: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
C: d6s229e (homo sapiens) (aka zinc finger protein 76)
D: d6s82e (homo sapiens) (aka abhydrolase doma... | [I; I] |
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [rep-8; d8s2298e]
<Options>: A: s8e (drosophila melanogaster) (aka ribosomal protein s8)
B: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
C: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
D: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1)
E: rep8h (mus... | [I; I] |
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [rep-8; d8s2298e]
<Options>: A: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
B: rep8h (mus musculus) (aka ubx domain protein 8)
C: rep15 (homo sapiens) (aka rab15 effector protein)
D: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
E: d0h8s2298e (mus musculus) (ak... | [G; G] |
<Instruct>: Given the context 'The gene consists of eight exons and spans about 20 kb between the glutathione S-reductase and the protein phosphatase 2A beta subunit genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [glutathione s-reductase]
<Options>: A: glutathione synthetase (sus scrofa) (aka glutathione synthetase)
B: gsr (sus scrofa) (aka glutathione-disulfide reductase)
C: gsr (homo sapiens) (aka glutathione-disulfide reductase)
D: gshs (homo sapiens) (aka glutathione synthetase)
E: glutathione-disulfide reductas... | [C] |
<Instruct>: Given the context 'The full-length Rep-8 gene contains 1483 nucleotides and codes for a protein of 270 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8]
<Options>: A: rep-1 (homo sapiens) (aka chm rab escort protein)
B: rep8h (mus musculus) (aka ubx domain protein 8)
C: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1)
D: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
E: rep8... | [E] |
<Instruct>: Given the context 'Southern blot experiments showed that the Rep-8 gene exists as a single copy per haploid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8]
<Options>: A: rep-1 (homo sapiens) (aka chm rab escort protein)
B: rep8 (xenopus tropicalis) (aka ubx domain protein 8)
C: rep8 (homo sapiens) (aka ubx domain protein 8)
D: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
E: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1)
F: N... | [C] |
<Instruct>: Given the context 'With a zoo blot analysis, human Rep-8 DNA hybridized strongly with the monkey DNA, but only weakly with the DNAs of species other than Homo sapiens.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [rep-8]
<Options>: A: rep8 (xenopus tropicalis) (aka ubx domain protein 8)
B: rep-1 (homo sapiens) (aka chm rab escort protein)
C: rep8 (homo sapiens) (aka ubx domain protein 8)
D: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4)
E: rep15 (homo sapiens) (aka rab15 effector pro... | [C] |
<Instruct>: Given the context 'Northern blot analysis showed that it is expressed abundantly in the testis and ovary, suggesting that the Rep-8 gene product may play a role in reproduction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rep-8]
<Options>: A: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4)
B: rep8h (mus musculus) (aka ubx domain protein 8)
C: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
D: rep15 (homo sapiens) (aka rab15 effec... | [E] |
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
B: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4)
C: kit ligand (homo sapiens) (aka kit ligand)
D: kit proto-oncogene, rec... | [D; J] |
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: fms (mus musculus) (aka colony stimulating factor 1 receptor)
B: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
C: kitl (homo sapiens) (aka kit ligand)
D: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine... | [B; J] |
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
B: fms related receptor tyrosine kinase 3 (homo sapiens) (aka fms related receptor tyrosine kinase 3)
C: kitl (homo sapiens) (aka kit ligand)
D: fms (escherichia coli str. ... | [A; F] |
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
B: c-fms (homo sapiens) (aka colony stimulating factor 1 receptor)
C: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4)
D:... | [E; B] |
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
B: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
C: cd116 (homo sapiens) (aka colony stimulating factor 2 re... | [I; J] |
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
B: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
C: fms (escherichia coli str. k-12 substr. mg1655) (aka peptid... | [I; H] |
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [kit]
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
B: kit ligand (homo sapiens) (aka kit ligand)
C: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
D: kit proto-oncogene... | [E] |
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [kit]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
B: kit ligand (homo sapiens) (aka kit ligand)
C: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
D: kit proto-oncog... | [E] |
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
B: flt-1 (homo sapiens) (aka fms related receptor tyrosine kinase 1)
C: fms related receptor tyrosine kinase 3 (homo sapiens) (aka fms related receptor tyrosine kinase 3)
... | [F; G] |
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: fms related receptor tyrosine kinase 1 (homo sapiens) (aka fms related receptor tyrosine kinase 1)
B: kit ligand (homo sapiens) (aka kit ligand)
C: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
D: c-kit (homo sapiens) (a... | [D; H] |
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [smf; fms]
<Options>: A: small ribonucleoprotein particle protein smf (drosophila melanogaster) (aka small ribonucleoprotein particle protein smf)
B: smfn (mus musculus) (aka rna exonuclease 2)
C: myhsf (mus musculus) (aka myosin, heavy polypeptide 4, skeletal muscle)
D: smf (mus musculus) (aka small nuclea... | [K; H] |
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [smf; fms]
<Options>: A: sm-f (homo sapiens) (aka small nuclear ribonucleoprotein polypeptide f)
B: myhsf (mus musculus) (aka myosin, heavy polypeptide 4, skeletal muscle)
C: fms (mus musculus) (aka colony stimulating factor 1 receptor)
D: fms related receptor tyrosine kinase 1 (homo sapiens) (aka fms relat... | [K; H] |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [56 kda selenium binding protein; hsp56]
<Options>: A: ss56 (homo sapiens) (aka tripartite motif containing 68)
B: selenium binding protein 1 (homo sapiens) (aka selenium binding protein 1)
C: selenium binding protein 1 (bos taurus) (aka selenium binding protein 1)
D: selenium binding protein 1 (gallus gall... | [B; B] |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [56 kda selenium binding protein; hsp56]
<Options>: A: prss56 (homo sapiens) (aka serine protease 56)
B: sbp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog)
C: ss56 (homo sapiens) (aka tripartite motif containing 68)
D: pp5656 (homo sap... | [I; I] |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [56 kda selenium binding protein; hsp56]
<Options>: A: sbp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog)
B: ss56 (homo sapiens) (aka tripartite motif containing 68)
C: selenium binding protein 1 (xenopus tropicalis) (aka selenium bind... | [D; D] |
<Instruct>: Given the context 'Using Northern blot hybridization, we found that this 56 kDa selenium binding protein is expressed in mouse heart with an intermediate level between those found in liver/lung/kidney and intestine.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [56 kda selenium binding protein]
<Options>: A: sp56 (xenopus laevis) (selenium binding protein 1 l homeolog (xenopus laevis)) (aka selenium binding protein 1 l homeolog)
B: selenium binding protein 1 (bos taurus) (aka selenium binding protein 1)
C: selenium binding protein 1 (gallus gallus) (aka selenium b... | [D] |
<Instruct>: Given the context 'We have also successfully expressed hSP56 in Escherichia coli using the expression vector-pAED4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsp56]
<Options>: A: sp56 (homo sapiens) (aka selenium binding protein 1)
B: prss56 (homo sapiens) (aka serine protease 56)
C: spg56 (homo sapiens) (aka cytochrome p450 family 2 subfamily u member 1)
D: hca56 (homo sapiens) (aka eukaryotic translation initiation factor 2d)
E: hc56 (homo sapiens) (aka gem n... | [A] |
<Instruct>: Given the context 'The hSP56 gene is located at human chromosome 1q21-22).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsp56]
<Options>: A: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
B: ss56 (homo sapiens) (aka tripartite motif containing 68)
C: sp56 (homo sapiens) (aka selenium binding protein 1)
D: spg56 (homo sapiens) (aka cytochrome p450 family 2 subfamily u member 1)
E: prss56 (homo sapiens) (aka serine protea... | [C] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: drm-pk-1 (drosophila melanogaster) (aka capability)
B: dystrophia myotonica-protein kinase (mus musculus) (aka dystrophia myotonica-protein kinase)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: dm1 pro... | [M; K; K] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: dm1 (homo sapiens) (dm1 protein kinase (homo sapiens)) (aka dm1 protein kinase)
B: dm1 protein kinase (xenopus tropicalis) (aka dm1 protein kinase)
C: l(2)k04218 (drosophila melanogaster) (aka charlatan)
D: dtymk (mus musculus) (aka deoxythymid... | [J; A; A] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
B: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
C: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
D: dmkp (drosophila melanogaster) (aka map ki... | [A; J; J] |
<Instruct>: Given the context 'Northern blots demonstrate that PK428 mRNA is distributed widely among tissues and is expressed at the highest levels in pancreas, heart, and skeletal muscle, with lower levels in liver and lung.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [pk428]
<Options>: A: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
B: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
E: cg42828 (drosophila mel... | [C] |
<Instruct>: Given the context 'Two PK428 mRNAs 10 and 3.8 kilobase pairs in size are seen in a number of cell lines, including hematopoietic and breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [pk428]
<Options>: A: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
B: l(2)k05428 (drosophila melanogaster) (aka dribble)
C: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
D: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
E: cg42828 (drosophila melanogaster) (aka ... | [D] |
<Instruct>: Given the context 'Immunoprecipitation of the transiently expressed PK428 protein and incubation with [gamma-32P]ATP demonstrate that it is capable of autophosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [pk428]
<Options>: A: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
B: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
E: pk428... | [E] |
<Instruct>: Given the context 'In addition, immunoprecipitates of the PK428 protein kinase also phosphorylated histone H1 and a peptide encoding a cyclic AMP-dependent protein kinase substrate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [pk428]
<Options>: A: l(2)k05428 (drosophila melanogaster) (aka dribble)
B: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein bet... | [C] |
<Instruct>: Given the context 'The gene corresponding to the 3.8-kb PK428 mRNA, and its corresponding 65-kDa protein, was isolated by polymerase chain reaction screening of a P1 phage human genomic library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [pk428]
<Options>: A: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
B: cg43428 (drosophila melanogaster) (aka uncharacterized protein)
C: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
D: cg42828 (drosophila melanogaster) (aka uncharacterized protein)... | [E] |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concep... | <Mentions>: [pk428; a gene associated with rippling muscle disease]
<Options>: A: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein beta subunit)
B: reactive intermediate imine deaminase a homolog (mus musculus) (aka reactive intermediate imine deaminase a homolog)
C: l(2)k05428 (drosophila ... | [I; D] |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concep... | <Mentions>: [pk428; a gene associated with rippling muscle disease]
<Options>: A: l(2)k05428 (drosophila melanogaster) (aka dribble)
B: reactive intermediate imine deaminase a homolog (gallus gallus) (aka reactive intermediate imine deaminase a homolog)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D... | [C; E] |
<Instruct>: Given the context 'Isolation and characterization of a structural homologue of human PRK2 from rat liver.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [prk2]
<Options>: A: pkc2 (homo sapiens) (aka protein kinase c zeta)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: prkcb2 (homo sapiens) (aka protein kinase c beta)
D: prk2 (homo sapiens) (aka protein kinase n2)
E: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: g protein-coupled receptor kinase 2 (homo sapiens) (aka g protein-coupled receptor kinase 2)
B: protein kinase c-like 2 (xenopus tropicalis) (aka protein kinase c-like 2)
C: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila ... | [G; G; O] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
C: prkcb2 (homo sapiens) (aka protein kinase c beta)
D: pak2 (drosophila melanogaster) (p21-act... | [E; E; N] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: g protein-coupled receptor kinase 2 (homo sapiens) (aka g protein-coupled receptor kinase 2)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: pak-2... | [M; M; M] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pkc2 (homo sapiens) (aka protein kinase c zeta)
C: calcium/calmodulin dependent protein kinase kinase 2 (homo sapiens) (aka calcium... | [D; D; O] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: protein kinase n (drosophila melanogaster) (aka protein kinase n)
C: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacte... | [T; T; T; R] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: ndpkc (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 3)
D: pkn (drosophila melanogaster) (uncharacter... | [T; T; T; H] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: pak-1 (homo sapiens) (aka protein kinase n1)
C: protein kinase n2 (homo sapiens) (aka protein kinase n2)
D: pkn (mus musculus) (aka protein kinase n1)
E: pak-2 (homo sapiens) (a... | [R; R; R; C] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
D: stk7 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n... | [T; T; T; D] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [prk2]
<Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: pkc2 (homo sapiens) (aka protein kinase c zeta)
E: prkcb2 (homo sapiens) (aka protein kinase c beta)
F: None of ... | [C] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [prk2]
<Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: pkc2 (homo sapiens) (aka protein kinase c zeta)
D: prkcb2 (homo sapiens) (aka protein kinase c beta)
E: None of the above. | [E] |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [pak-2; prk2]
<Options>: A: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
D: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
E: pak-2 (hom... | [K; E] |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [pak-2; prk2]
<Options>: A: prk2 (homo sapiens) (aka protein kinase n2)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
D: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
E: prkg2 (homo sapiens) (aka protein kinase... | [J; A] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
D: prkcb2 (homo sapiens) (aka protein kinase c beta)
E: p... | [S; K; S; S] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: pak-1 (homo sapiens) (aka protein kinase n1)
C: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
E: pkn (mus ... | [T; P; T; T] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkn (mus musculus) (aka protein kinase n1)
B: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: pk2 (homo sapiens) (aka prokineticin 2)
D: pkn (homo sapiens) (aka protein kinase n1)
E: pkn2 (homo sapiens) (aka protein kinase n2)
F: pak2 (homo sapiens) (... | [T; N; T; T] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: pak-3beta (homo sapiens) (aka p21 (rac1) acti... | [S; N; S; S] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: prkcb2 (homo sapiens) (aka protein kinase c beta)
D: pk2 (homo sapiens) (aka prokineticin 2)
E: pak-2 (homo sapiens) (aka protein kinase n2)
F: pak-1 (ho... | [R; R; R; R] |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [pak-2; prk2]
<Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
C: pk2 (homo sapiens) (aka prokineticin 2)
D: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
E: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated ki... | [K; A] |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [pak-2; prk2]
<Options>: A: prk2 (homo sapiens) (aka protein kinase n2)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
D: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
E: pak2 (drosophila melanogaster) ... | [K; A] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
C: pak-6 (homo sapiens) (aka bub1b-pak6 readthrough)
... | [S; E; S; S] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
C: pkn (homo sapiens) (aka protein kinase n1)
D:... | [T; O; T; T] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkc2 (homo sapiens) (aka protein kinase c zeta)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
D: pkn (d... | [U; E; U; U] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
B: pkc2 (homo sapiens) (aka protein kinase c zeta)
C: prkn (bos taurus) (aka parkin rbr e3 ubiquitin protein ligase)
D: p65-pak (homo sapiens) (aka p21 (rac1) activated kinase 1)
E: pk2 (homo sapiens) (aka prokineticin... | [S; N; S; S] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
B: p65-pak (homo sapiens) (aka p21 (rac1) activated kinase 1)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1... | [R; R; R; R] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [prk1]
<Options>: A: pkn (homo sapiens) (aka protein kinase n1)
B: prk (homo sapiens) (aka polo like kinase 3)
C: prka1 (homo sapiens) (aka a-kinase anchoring protein 1)
D: prkaa1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
E: serine/threonine protein kinase prk1 (saccharomyc... | [A] |
<Instruct>: Given the context 'Human dipeptidyl-peptidase I. Gene characterization, localization, and expression.
Dipeptidyl-peptidase I, a lysosomal cysteine proteinase, is important in intracellular degradation of proteins and appears to be a central coordinator for activation of many serine proteinases in immune/inf... | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dpp-i (homo sapiens) (aka cathepsin c)
B: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
... | [A] |
<Instruct>: Given the context 'In the present investigation the gene for dipeptidyl-peptidase I was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
B: ii (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
C: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
D: dppi (homo sapiens) (aka cathepsin c)
E: dipeptidyl pep... | [D] |
<Instruct>: Given the context 'Northern analyses demonstrated that the dipeptidyl-peptidase I message is expressed at high levels in lung, kidney, and placenta, at moderate to low levels in many organs, and at barely detectable levels in the brain, suggesting tissue-specific regulation.', select the correct biomedical ... | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
C: dppi (homo sapiens) (aka cathepsin c)
D: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidas... | [C] |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [interleukin-2; dipeptidyl-peptidase i]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
C: dipeptidyl peptidase 7 (homo sapiens) (aka dipeptidyl peptidase 7)
D: ilf2 (homo sapiens) (aka... | [I; F] |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [interleukin-2; dipeptidyl-peptidase i]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
C: dpp1 (homo sapiens) (aka cathepsin c)
D: il-2 (homo sapiens) (aka interleukin 2)
E: colony stimulating factor 2 (homo sapiens) (aka colony stimulating... | [D; C] |
<Instruct>: Given the context 'The results provide initial insights into the molecular basis for the regulation of human dipeptidyl-peptidase I.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
C: dpp1 (homo sapiens) (aka cathepsin c)
D: ii (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)... | [C] |
<Instruct>: Given the context 'Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin]
<Options>: A: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
B: opgl (rattus norvegicus) (aka tnf superfamily member 11)
C: opgl (homo sapiens) (aka tnf superfamily member 11)
D: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor su... | [D] |
<Instruct>: Given the context 'Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin]
<Options>: A: gitr (homo sapiens) (aka tnf receptor superfamily member 18)
B: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
C: opgl (rattus norvegicus) (aka tnf superfamily member 11)
D: opgl (homo sapiens) (aka tnf superfamily member 11)
E: None of the above. | [E] |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin; opg]
<Options>: A: opgl (homo sapiens) (aka tnf superfamily member 11)
B: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
C: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
D: gitrl (homo sapiens) (aka tnf ... | [C; C] |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin; opg]
<Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: gitr (homo sapiens) (aka tnf receptor superfamily member 18)
C: rankl (homo sapiens) (aka tnf superfamily member 11)
D: tweakr (homo sapiens) (aka tnf rec... | [A; A] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.