instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha1(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
C: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
D: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
E: vla5a (homo sapiens) (aka integrin subunit alpha 5)
F: None of the above. | A |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha2(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
D: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
E: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
F: None of the above. | C |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
D: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
E: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
F: None of the above. | A |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
D: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
F: None of the above. | B |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha1(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
E: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
F: None of the above. | A |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha2(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
C: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
D: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
E: vla5a (homo sapiens) (aka integrin subunit alpha 5)
F: None of the above. | B |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
D: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
F: None of the above. | E |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
E: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
F: None of the above. | F |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
D: vla3a (homo sapiens) (aka integrin subunit alpha 3)
E: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha1(v)'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
E: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
F: None of the above. | E |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha2(v)'. Answer using one of the provided options. | <Options>: A: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
B: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
C: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
D: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
E: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
F: None of the above. | E |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
D: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
E: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
F: None of the above. | E |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha3(v)'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
D: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
E: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
F: None of the above. | C |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'col5a3'. Answer using one of the provided options. | <Options>: A: col6a3 (homo sapiens) (aka collagen type vi alpha 3 chain)
B: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
C: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
D: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
E: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
F: None of the above. | E |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha1(v)'. Answer using one of the provided options. | <Options>: A: vla5a (homo sapiens) (aka integrin subunit alpha 5)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
E: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
F: None of the above. | E |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least some cases of the hypermobility type of EDS, a condition marked by gross joint laxity and chronic musculoskeletal pain.', select the correct biomedical concept corresponding to 'alpha2(v)'. Answer using one of the provided options. | <Options>: A: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
B: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
E: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
F: None of the above. | D |
<Instruct>: Given the context 'COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing linkage with EDS and other disease phenotypes.', select the correct biomedical concept corresponding to 'col5a3'. Answer using one of the provided options. | <Options>: A: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: col6a3 (homo sapiens) (aka collagen type vi alpha 3 chain)
D: col5a2 (homo sapiens) (aka collagen type v alpha 2 chain)
E: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
F: None of the above. | B |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
C: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
D: mdm2 proto-oncogene (homo sapiens) (aka mdm2 proto-oncogene)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
F: None of the above. | D |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: p53 (homo sapiens) (aka tumor protein p53)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: None of the above. | D |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: tumor protein p73 (homo sapiens) (aka tumor protein p73)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: ct53 (homo sapiens) (aka zinc finger protein 165)
F: None of the above. | F |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
F: None of the above. | B |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: p53cp (homo sapiens) (aka tumor protein p63)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: tumor protein p53 (homo sapiens) (aka tumor protein p53)
F: None of the above. | E |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: trp53 (homo sapiens) (aka tumor protein p53)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: ct53 (homo sapiens) (aka zinc finger protein 165)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: None of the above. | B |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
D: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
E: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
F: None of the above. | E |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: p53cp (homo sapiens) (aka tumor protein p63)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: p53 (homo sapiens) (aka tumor protein p53)
F: None of the above. | E |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
D: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
E: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept corresponding to 'ubiquitin-activating enzyme (e1)'. Answer using one of the provided options. | <Options>: A: ubiquitin-like modifier-activating enzyme 1 (gallus gallus) (aka ubiquitin-like modifier-activating enzyme 1)
B: ubiquitin-like modifier activating enzyme 1 (xenopus tropicalis) (aka ubiquitin-like modifier activating enzyme 1)
C: ubiquitin like modifier activating enzyme 7 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
D: ubiquitin-activating enzyme 1 (arabidopsis thaliana) (aka ubiquitin-activating enzyme 1)
E: ubiquitin like modifier activating enzyme 1 (homo sapiens) (aka ubiquitin like modifier activating enzyme 1)
F: None of the above. | C |
<Instruct>: Given the context 'It is apparent, therefore, that Mdm2 manifests an intrinsic capacity to mediate ubiquitination.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
C: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
E: mdm2bp (homo sapiens) (aka mdm2 binding protein)
F: None of the above. | A |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: p53 (homo sapiens) (aka tumor protein p53)
C: tumor protein p73 (homo sapiens) (aka tumor protein p73)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: ct53 (homo sapiens) (aka zinc finger protein 165)
F: None of the above. | B |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2 (homo sapiens) (aka mdm2 proto-oncogene)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: mdm2bp (homo sapiens) (aka mdm2 binding protein)
D: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
E: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
F: None of the above. | A |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
C: mdm2bp (homo sapiens) (aka mdm2 binding protein)
D: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
E: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
F: None of the above. | F |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
C: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
D: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
E: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
F: None of the above. | B |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
B: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
C: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
D: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
E: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
F: None of the above. | B |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept corresponding to 'praja1'. Answer using one of the provided options. | <Options>: A: praja ring finger ubiquitin ligase 1 (bos taurus) (aka praja ring finger ubiquitin ligase 1)
B: praja ring finger ubiquitin ligase 2 (homo sapiens) (aka praja ring finger ubiquitin ligase 2)
C: praja ring finger ubiquitin ligase 1 (mus musculus) (aka praja ring finger ubiquitin ligase 1)
D: praja1 (homo sapiens) (aka praja ring finger ubiquitin ligase 1)
E: pra1 (homo sapiens) (aka rab acceptor 1)
F: None of the above. | D |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept corresponding to 'mdm2'. Answer using one of the provided options. | <Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
D: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
E: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
F: None of the above. | D |
<Instruct>: Given the context 'However, this RING was ineffective in ubiquitination and proteasomal targeting of p53, suggesting that there may be specificity at the level of the RING in the recognition of heterologous substrates.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: tp53 (homo sapiens) (aka tumor protein p53)
B: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: None of the above. | A |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: endomucin (homo sapiens) (aka endomucin)
C: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
F: None of the above. | D |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
B: cd344 (homo sapiens) (aka frizzled class receptor 4)
C: cd34 molecule (homo sapiens) (aka cd34 molecule)
D: cd34 (sus scrofa) (aka cd34 molecule)
E: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
F: None of the above. | C |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'podocalyxin'. Answer using one of the provided options. | <Options>: A: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
B: podocalyxin like (oryctolagus cuniculus) (aka podocalyxin like)
C: podocalyxin like (bos taurus) (aka podocalyxin like)
D: podocalyxin like (homo sapiens) (aka podocalyxin like)
E: podocalyxin like s homeolog (xenopus laevis) (aka podocalyxin like s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 molecule (homo sapiens) (aka cd34 molecule)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
F: None of the above. | A |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'podocalyxin'. Answer using one of the provided options. | <Options>: A: podn (homo sapiens) (aka podocan)
B: podocalyxin like (homo sapiens) (aka podocalyxin like)
C: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
D: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
E: podocalyxin like s homeolog (xenopus laevis) (aka podocalyxin like s homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept corresponding to 'podocalyxin'. Answer using one of the provided options. | <Options>: A: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
B: podocalyxin like (bos taurus) (aka podocalyxin like)
C: podocalyxin like (oryctolagus cuniculus) (aka podocalyxin like)
D: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
E: podn (homo sapiens) (aka podocan)
F: None of the above. | F |
<Instruct>: Given the context 'Using homologies present in the cytoplasmic tails of these proteins, we have identified a novel member of this family, which we designate endoglycan.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
B: eg (homo sapiens) (aka podocalyxin like 2)
C: endoglin (sus scrofa) (aka endoglin)
D: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
E: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
F: None of the above. | B |
<Instruct>: Given the context 'In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: endoglin (sus scrofa) (aka endoglin)
C: endomucin (homo sapiens) (aka endomucin)
D: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
E: eg (homo sapiens) (aka podocalyxin like 2)
F: None of the above. | E |
<Instruct>: Given the context 'Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
C: endoglin (homo sapiens) (aka endoglin)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
F: None of the above. | D |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: cd34 (gallus gallus) (aka cd34 molecule)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: fat4 (homo sapiens) (aka fat atypical cadherin 4)
F: None of the above. | D |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept corresponding to 'podocalyxin'. Answer using one of the provided options. | <Options>: A: podocalyxin like (bos taurus) (aka podocalyxin like)
B: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
C: podocalyxin like s homeolog (xenopus laevis) (aka podocalyxin like s homeolog)
D: podocalyxin like (homo sapiens) (aka podocalyxin like)
E: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
F: None of the above. | D |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: endoglin (homo sapiens) (aka endoglin)
B: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
C: eg (homo sapiens) (aka podocalyxin like 2)
D: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
E: endomucin (homo sapiens) (aka endomucin)
F: None of the above. | C |
<Instruct>: Given the context 'While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.', select the correct biomedical concept corresponding to 'endoglycan'. Answer using one of the provided options. | <Options>: A: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
B: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
C: eg (homo sapiens) (aka podocalyxin like 2)
D: endomucin (homo sapiens) (aka endomucin)
E: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
F: None of the above. | C |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept corresponding to '8d6'. Answer using one of the provided options. | <Options>: A: 8d6a (homo sapiens) (aka cd320 molecule)
B: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
C: defa6 (homo sapiens) (aka defensin alpha 6)
D: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
E: d6 (homo sapiens) (aka atypical chemokine receptor 2)
F: None of the above. | A |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept corresponding to '8d6 antigen (ag)'. Answer using one of the provided options. | <Options>: A: 8d6 (homo sapiens) (aka cd320 molecule)
B: mer6 (homo sapiens) (aka cd47 molecule)
C: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
D: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
E: 8d6 (mus musculus) (aka cd320 antigen)
F: None of the above. | A |
<Instruct>: Given the context 'The 8D6 Ag is a novel protein of 282 amino acids that is expressed abundantly on FDCs.', select the correct biomedical concept corresponding to '8d6 ag'. Answer using one of the provided options. | <Options>: A: 8d6a (homo sapiens) (aka cd320 molecule)
B: 8d6 (mus musculus) (aka cd320 antigen)
C: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
D: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
E: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
F: None of the above. | A |
<Instruct>: Given the context 'The 8D6 Ag is a novel protein of 282 amino acids that is expressed abundantly on FDCs.', select the correct biomedical concept corresponding to '8d6 ag'. Answer using one of the provided options. | <Options>: A: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
B: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
C: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
D: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
E: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | F |
<Instruct>: Given the context 'Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth.', select the correct biomedical concept corresponding to '8d6 ag'. Answer using one of the provided options. | <Options>: A: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
C: 8d6 (homo sapiens) (aka cd320 molecule)
D: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
E: tspan-6 (homo sapiens) (aka tetraspanin 6)
F: None of the above. | C |
<Instruct>: Given the context 'The mAb 8D6 blocks the costimulatory function completely.', select the correct biomedical concept corresponding to '8d6'. Answer using one of the provided options. | <Options>: A: 8d6 (mus musculus) (aka cd320 antigen)
B: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
C: d6 (homo sapiens) (aka atypical chemokine receptor 2)
D: 8d6 (homo sapiens) (aka cd320 molecule)
E: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
F: None of the above. | D |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept corresponding to '8d6'. Answer using one of the provided options. | <Options>: A: 8d6 (mus musculus) (aka cd320 antigen)
B: 8d6a (homo sapiens) (aka cd320 molecule)
C: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
D: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
E: d8 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
F: None of the above. | B |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept corresponding to 'cd40'. Answer using one of the provided options. | <Options>: A: cd40 (homo sapiens) (aka cd40 molecule)
B: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
C: cd40l (homo sapiens) (aka cd40 ligand)
D: tnfrsf4 (homo sapiens) (aka tnf receptor superfamily member 4)
E: cd40 molecule (bos taurus) (aka cd40 molecule)
F: None of the above. | A |
<Instruct>: Given the context 'In addition, the mAb 8D6 inhibits the growth of a lymphoma of GC origin, L3055, which depends on FDCs or HK cells for its growth.', select the correct biomedical concept corresponding to '8d6'. Answer using one of the provided options. | <Options>: A: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
B: 8d6 (homo sapiens) (aka cd320 molecule)
C: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
D: d6 (homo sapiens) (aka atypical chemokine receptor 2)
E: defa6 (homo sapiens) (aka defensin alpha 6)
F: None of the above. | B |
<Instruct>: Given the context 'An FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.', select the correct biomedical concept corresponding to '8d6 ag'. Answer using one of the provided options. | <Options>: A: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
B: 8d6 (homo sapiens) (aka cd320 molecule)
C: tspan-6 (homo sapiens) (aka tetraspanin 6)
D: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
E: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | B |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept corresponding to 'leukosialin'. Answer using one of the provided options. | <Options>: A: spn (xenopus tropicalis) (sialophorin (xenopus tropicalis)) (aka sialophorin)
B: galn (homo sapiens) (aka galanin and gmap prepropeptide)
C: sialin (homo sapiens) (aka solute carrier family 17 member 5)
D: granulysin (homo sapiens) (aka granulysin)
E: sialophorin (homo sapiens) (aka sialophorin)
F: None of the above. | E |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd49c (homo sapiens) (aka integrin subunit alpha 3)
B: cd46 (homo sapiens) (aka cd46 molecule)
C: gp3a (homo sapiens) (aka integrin subunit beta 3)
D: cd43 (xenopus tropicalis) (aka sialophorin)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | E |
<Instruct>: Given the context 'This study analyzed the behavior of an antiadhesive membrane molecule, CD43, in neutrophil polarization and locomotion.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
C: cd43 (xenopus tropicalis) (aka sialophorin)
D: cd46 (homo sapiens) (aka cd46 molecule)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | E |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd43 (homo sapiens) (aka sialophorin)
B: cd43 (xenopus tropicalis) (aka sialophorin)
C: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
D: gp3a (homo sapiens) (aka integrin subunit beta 3)
E: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
F: None of the above. | A |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: cd43 (xenopus tropicalis) (aka sialophorin)
C: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
D: cd46 (homo sapiens) (aka cd46 molecule)
E: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: None of the above. | F |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
C: cd43 (xenopus tropicalis) (aka sialophorin)
D: cd43 (homo sapiens) (aka sialophorin)
E: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
F: None of the above. | D |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept corresponding to 'cd11b'. Answer using one of the provided options. | <Options>: A: cd11b (homo sapiens) (aka integrin subunit alpha m)
B: cd11a (mus musculus) (aka integrin alpha l)
C: cd11b (bos taurus) (aka integrin subunit alpha m)
D: cd11b (mus musculus) (aka integrin alpha m)
E: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
F: None of the above. | A |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept corresponding to 'cd18'. Answer using one of the provided options. | <Options>: A: slamf8 (homo sapiens) (aka slam family member 8)
B: cd128 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
C: cd118 (homo sapiens) (aka lif receptor subunit alpha)
D: cd18 (homo sapiens) (aka integrin subunit beta 2)
E: cd15 (homo sapiens) (aka fucosyltransferase 4)
F: None of the above. | D |
<Instruct>: Given the context 'Stimulation of suspended or adherent neutrophils with chemotactic peptide results in cell polarization and locomotion and a concomitant redistribution of CD43 to the uropod.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd43 (xenopus tropicalis) (aka sialophorin)
B: cd43 (homo sapiens) (aka sialophorin)
C: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
D: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
E: gp3a (homo sapiens) (aka integrin subunit beta 3)
F: None of the above. | B |
<Instruct>: Given the context 'The study also investigated which actin-binding protein could be involved in CD43 lateral redistribution.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
D: cd43 (homo sapiens) (aka sialophorin)
E: gp3a (homo sapiens) (aka integrin subunit beta 3)
F: None of the above. | D |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept corresponding to 'alpha-actinin'. Answer using one of the provided options. | <Options>: A: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
B: actn4 (homo sapiens) (aka actinin alpha 4)
C: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
D: actn1 (homo sapiens) (aka actinin alpha 1)
E: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept corresponding to 'moesin'. Answer using one of the provided options. | <Options>: A: moesin s homeolog (xenopus laevis) (aka moesin s homeolog)
B: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
C: moesin (mus musculus) (aka moesin)
D: moesin/ezrin/radixin homolog mrna (drosophila melanogaster) (aka moesin)
E: moesin (homo sapiens) (aka moesin)
F: None of the above. | E |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept corresponding to 'moesin'. Answer using one of the provided options. | <Options>: A: moesin s homeolog (xenopus laevis) (aka moesin s homeolog)
B: moesin (homo sapiens) (aka moesin)
C: moesin (mus musculus) (aka moesin)
D: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
E: moesin/ezrin/radixin homolog mrna (drosophila melanogaster) (aka moesin)
F: None of the above. | B |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: gp3a (homo sapiens) (aka integrin subunit beta 3)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
D: cd43 (homo sapiens) (aka sialophorin)
E: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: None of the above. | D |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept corresponding to 'alpha-actinin'. Answer using one of the provided options. | <Options>: A: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
B: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
C: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
D: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
E: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept corresponding to 'alpha-actinin'. Answer using one of the provided options. | <Options>: A: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
B: actn4 (homo sapiens) (aka actinin alpha 4)
C: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
D: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
E: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd49c (homo sapiens) (aka integrin subunit alpha 3)
B: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
C: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
D: cd43 (homo sapiens) (aka sialophorin)
E: cd46 molecule (homo sapiens) (aka cd46 molecule)
F: None of the above. | D |
<Instruct>: Given the context 'These results shed new light on the role of CD43 membrane redistribution, which appears to be directly related to neutrophil polarity and locomotion.', select the correct biomedical concept corresponding to 'cd43'. Answer using one of the provided options. | <Options>: A: cd49c (homo sapiens) (aka integrin subunit alpha 3)
B: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
C: cd43 (homo sapiens) (aka sialophorin)
D: cd46 molecule (homo sapiens) (aka cd46 molecule)
E: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
F: None of the above. | C |
<Instruct>: Given the context 'Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells.', select the correct biomedical concept corresponding to 'kiaa0001'. Answer using one of the provided options. | <Options>: A: kiaa0100 (homo sapiens) (aka bridge-like lipid transfer protein family member 2)
B: eg:eg0001.1 (drosophila melanogaster) (aka pepsinogen c-like)
C: gene1 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
D: heat repeat-containing protein 1 homolog (caenorhabditis elegans) (aka heat repeat-containing protein 1 homolog)
E: eg:96g10.1 (drosophila melanogaster) (aka pre-intermoult gene 1)
F: None of the above. | F |
<Instruct>: Given the context 'Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell.', select the correct biomedical concept corresponding to 'alpha1a voltage-dependent calcium channel'. Answer using one of the provided options. | <Options>: A: cacna1s (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 s)
B: cms1a (homo sapiens) (cholinergic receptor nicotinic alpha 1 subunit (homo sapiens)) (aka cholinergic receptor nicotinic alpha 1 subunit)
C: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
D: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
E: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
F: None of the above. | E |
<Instruct>: Given the context 'A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
B: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
C: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
E: a1a (homo sapiens) (aka serpin family a member 1)
F: None of the above. | C |
<Instruct>: Given the context 'A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
D: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
E: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
F: None of the above. | B |
<Instruct>: Given the context 'Human alpha1A channels carrying various polyglutamine length with or without NP were expressed in HEK293 cells, and channel properties were compared using a whole-cell voltage clamp technique.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
C: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
D: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
E: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
F: None of the above. | A |
<Instruct>: Given the context 'alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
D: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
E: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
F: None of the above. | B |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
E: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
F: None of the above. | C |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
B: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
C: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
D: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
E: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
F: None of the above. | E |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
B: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
C: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
D: a1a (homo sapiens) (aka serpin family a member 1)
E: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
F: None of the above. | F |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
D: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: a1a (homo sapiens) (aka serpin family a member 1)
F: None of the above. | D |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alpha1A(-NP), due to the reduced Ca(2+) influx resulting from the negative shift of voltage-dependent inactivation.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: a1a (homo sapiens) (aka serpin family a member 1)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: a1a (homo sapiens) (aka serpin family a member 1)
E: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
F: None of the above. | A |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: a1a (homo sapiens) (aka serpin family a member 1)
C: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
D: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
E: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
F: None of the above. | A |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept corresponding to 'alpha1a'. Answer using one of the provided options. | <Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: adra1a (homo sapiens) (adrenoceptor alpha 1a (homo sapiens)) (aka adrenoceptor alpha 1a)
C: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
E: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
F: None of the above. | C |
<Instruct>: Given the context 'Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.
', select the correct biomedical concept corresponding to 'six2'. Answer using one of the provided options. | <Options>: A: six2 (mus musculus) (aka sine oculis-related homeobox 2)
B: six2 (gallus gallus) (aka six homeobox 2)
C: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
D: six2 (homo sapiens) (aka six homeobox 2)
E: six6 (homo sapiens) (aka six homeobox 6)
F: None of the above. | D |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept corresponding to 'sine oculis'. Answer using one of the provided options. | <Options>: A: arctus oculus (drosophila melanogaster) (aka arctus oculus)
B: micro-oculus (drosophila melanogaster) (aka micro-oculus)
C: oculess (drosophila melanogaster) (aka oculess)
D: sine oculis (drosophila melanogaster) (aka sine oculis)
E: dood (homo sapiens) (aka atpase h+ transporting v1 subunit b2)
F: None of the above. | D |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept corresponding to 'so'. Answer using one of the provided options. | <Options>: A: soga (homo sapiens) (aka microtubule crosslinking factor 2)
B: soh1 (homo sapiens) (aka mediator complex subunit 31)
C: sov (drosophila melanogaster) (aka small ovary)
D: oss (drosophila melanogaster) (suppressor of hairless (drosophila melanogaster)) (aka suppressor of hairless)
E: so (drosophila melanogaster) (aka sine oculis)
F: None of the above. | E |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept corresponding to 'six5'. Answer using one of the provided options. | <Options>: A: six homeobox 5 (homo sapiens) (aka six homeobox 5)
B: six4/5 (drosophila melanogaster) (aka six4)
C: six homeobox 6 (homo sapiens) (aka six homeobox 6)
D: six5 (mus musculus) (aka sine oculis-related homeobox 5)
E: hairy and enhancer of split 5 gene 5 (xenopus tropicalis) (aka hairy and enhancer of split 5 gene 5)
F: None of the above. | A |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept corresponding to 'six6'. Answer using one of the provided options. | <Options>: A: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
B: six homeobox 6 (xenopus tropicalis) (aka six homeobox 6)
C: hoxa6 (homo sapiens) (aka homeobox a6)
D: paired box protein 6 homolog (caenorhabditis elegans) (aka paired box protein 6 homolog)
E: six homeobox 6 (homo sapiens) (aka six homeobox 6)
F: None of the above. | E |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept corresponding to 'six6'. Answer using one of the provided options. | <Options>: A: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
B: hoxa6 (homo sapiens) (aka homeobox a6)
C: six5 (homo sapiens) (aka six homeobox 5)
D: six6 (xenopus laevis) (aka six homeobox 6 l homeolog)
E: paired box protein 6 homolog (caenorhabditis elegans) (aka paired box protein 6 homolog)
F: None of the above. | F |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept corresponding to 'six3'. Answer using one of the provided options. | <Options>: A: six3 (drosophila melanogaster) (aka optix)
B: six6 (homo sapiens) (aka six homeobox 6)
C: six3 (xenopus laevis) (six homeobox 3 s homeolog (xenopus laevis)) (aka six homeobox 3 s homeolog)
D: hairy and enhancer of split 3 (xenopus tropicalis) (aka hairy and enhancer of split 3)
E: six homeobox 3 (homo sapiens) (aka six homeobox 3)
F: None of the above. | E |
<Instruct>: Given the context 'We have cloned and characterised the gene that encodes human SIX2, elucidated its gene structure and conducted expression studies in a range of tissues.', select the correct biomedical concept corresponding to 'six2'. Answer using one of the provided options. | <Options>: A: six4 (homo sapiens) (aka six homeobox 4)
B: six2 (mus musculus) (aka sine oculis-related homeobox 2)
C: six2 (homo sapiens) (aka six homeobox 2)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six6 (homo sapiens) (aka six homeobox 6)
F: None of the above. | C |
<Instruct>: Given the context 'SIX2 is widely expressed in the late first-trimester fetus, but has a limited range of expression sites in the adult.', select the correct biomedical concept corresponding to 'six2'. Answer using one of the provided options. | <Options>: A: six5 (homo sapiens) (aka six homeobox 5)
B: six2 (mus musculus) (aka sine oculis-related homeobox 2)
C: six homeobox 2 (homo sapiens) (aka six homeobox 2)
D: six4 (homo sapiens) (aka six homeobox 4)
E: six6 (homo sapiens) (aka six homeobox 6)
F: None of the above. | C |
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