instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'The expression pattern of SIX2 and its localisation to chromosome 2p15-p16 will be of use in assessing its candidacy in human developmental disorders.', select the correct biomedical concept corresponding to 'six2'. Answer using one of the provided options. | <Options>: A: six5 (homo sapiens) (aka six homeobox 5)
B: six6 (homo sapiens) (aka six homeobox 6)
C: six2 (mus musculus) (aka sine oculis-related homeobox 2)
D: six3 (homo sapiens) (aka six homeobox 3)
E: six homeobox 2 (homo sapiens) (aka six homeobox 2)
F: None of the above. | E |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept corresponding to 'parathyroid hormone-related peptide'. Answer using one of the provided options. | <Options>: A: parathyroid hormone-like hormone (rattus norvegicus) (aka parathyroid hormone-like hormone)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: parathyroid hormone-related protein-like (xenopus laevis) (aka parathyroid hormone-related protein-like)
E: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
F: None of the above. | C |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept corresponding to 'pth-related peptide'. Answer using one of the provided options. | <Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pro-trh (homo sapiens) (aka thyrotropin releasing hormone)
D: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
E: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
F: None of the above. | E |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
D: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
E: pthrp (bos taurus) (aka parathyroid hormone like hormone)
F: None of the above. | D |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept corresponding to 'pth'. Answer using one of the provided options. | <Options>: A: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
B: pth (homo sapiens) (parathyroid hormone (homo sapiens)) (aka parathyroid hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
E: hpt (homo sapiens) (aka hypoparathyroidism)
F: None of the above. | B |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept corresponding to 'pth/pthrp receptor'. Answer using one of the provided options. | <Options>: A: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
B: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
C: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
D: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
E: None of the above. | A |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthrp (bos taurus) (aka parathyroid hormone like hormone)
F: None of the above. | C |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pthrp (bos taurus) (aka parathyroid hormone like hormone)
F: None of the above. | F |
<Instruct>: Given the context 'Although initially discovered in malignancies, PTHrP is now known to be produced by most cells and tissues in the body.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
F: None of the above. | E |
<Instruct>: Given the context 'It acts as an autocrine and paracrine mediator of cell proliferation and differentiation, effects which are mediated via the PTH/PTHrP receptor.', select the correct biomedical concept corresponding to 'pth/pthrp receptor'. Answer using one of the provided options. | <Options>: A: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
B: parathyroid hormone 2 receptor (homo sapiens) (aka parathyroid hormone 2 receptor)
C: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
E: None of the above. | D |
<Instruct>: Given the context 'Recent evidence also has shown that, directly after translation, PTHrP is able to enter the nucleus and/or nucleolus and influence cell cycle progression and apoptosis.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
E: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pth promoter region (homo sapiens) (aka pth promoter region)
F: None of the above. | A |
<Instruct>: Given the context 'Overexpression of PTHrP was associated with an increase in mitogenesis, whereas inhibiting endogenous PTHrP production resulted in decreased cell proliferation.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
F: None of the above. | C |
<Instruct>: Given the context 'Overexpression of PTHrP was associated with an increase in mitogenesis, whereas inhibiting endogenous PTHrP production resulted in decreased cell proliferation.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
F: None of the above. | C |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept corresponding to 'pth/pthrp receptor'. Answer using one of the provided options. | <Options>: A: trhr (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: parathyroid hormone 1 receptor (homo sapiens) (aka parathyroid hormone 1 receptor)
C: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
D: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
E: None of the above. | B |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
E: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
F: None of the above. | A |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
F: None of the above. | F |
<Instruct>: Given the context 'Furthermore, neutralization of added peptide with an anti-PTHrP antiserum completely abolished the growth inhibitory effects.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
E: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'In contrast, this antibody has no effect on the increased proliferation rate of the MCF-7 transfectants that overexpress PTHrP, compared with control cells.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
F: None of the above. | E |
<Instruct>: Given the context 'The net effect of autocrine/paracrine and intracrine effects of PTHrP in MCF-7 cells overproducing the peptide is accelerated cell growth.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
F: None of the above. | C |
<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
F: None of the above. | E |
<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept corresponding to 'pthrp'. Answer using one of the provided options. | <Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept corresponding to 'p-selectin ligand'. Answer using one of the provided options. | <Options>: A: cd62l (homo sapiens) (aka selectin l)
B: selp (homo sapiens) (selectin p (homo sapiens)) (aka selectin p)
C: selectin p ligand (homo sapiens) (aka selectin p ligand)
D: selectin p ligand (sus scrofa) (aka selectin p ligand)
E: selectin-e (homo sapiens) (aka selectin e)
F: None of the above. | C |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
B: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
C: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
D: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
E: psgl1 (homo sapiens) (aka selectin p ligand)
F: None of the above. | E |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept corresponding to 'p-selectin'. Answer using one of the provided options. | <Options>: A: selectin p (homo sapiens) (aka selectin p)
B: selectin p (sus scrofa) (aka selectin p)
C: selectin l (homo sapiens) (aka selectin l)
D: selectin p ligand (homo sapiens) (aka selectin p ligand)
E: selectin e (homo sapiens) (aka selectin e)
F: None of the above. | A |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept corresponding to 'p-selectin glycoprotein ligand'. Answer using one of the provided options. | <Options>: A: selectin p ligand (sus scrofa) (aka selectin p ligand)
B: selectin l (homo sapiens) (aka selectin l)
C: cd62 (homo sapiens) (aka selectin p)
D: selectin p ligand (homo sapiens) (aka selectin p ligand)
E: selectin e (homo sapiens) (aka selectin e)
F: None of the above. | D |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
B: psgl1 (homo sapiens) (aka selectin p ligand)
C: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
D: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
E: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
F: None of the above. | B |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
B: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 5)
C: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
D: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
E: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
F: None of the above. | F |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 1 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 1)
B: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
C: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
D: psgl-1 (homo sapiens) (aka selectin p ligand)
E: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
F: None of the above. | D |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psgl1 (homo sapiens) (aka selectin p ligand)
B: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
C: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
D: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
E: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept corresponding to 'alpha-(1,3) fucosyltransferase'. Answer using one of the provided options. | <Options>: A: fucosyltransferase 9 (alpha (1,3) fucosyltransferase) (xenopus tropicalis) (aka fucosyltransferase 9 (alpha (1,3) fucosyltransferase))
B: fucosyltransferase 7 (homo sapiens) (aka fucosyltransferase 7)
C: alpha(1,3)fucosyltransferase gene 1 (danio rerio) (aka alpha(1,3)fucosyltransferase gene 1)
D: fuct1 (homo sapiens) (aka solute carrier family 35 member c1)
E: alpha1,3-fucosyltransferase a (drosophila melanogaster) (aka alpha1,3-fucosyltransferase a)
F: None of the above. | B |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept corresponding to 'fuc-tvii'. Answer using one of the provided options. | <Options>: A: fuc-tvii (mus musculus) (aka fucosyltransferase 7)
B: fuct-vii (homo sapiens) (aka fucosyltransferase 7)
C: fuct-vii (xenopus tropicalis) (aka fucosyltransferase 7 (alpha (1,3) fucosyltransferase))
D: fuc-tvii (rattus norvegicus) (aka fucosyltransferase 7)
E: fuct-iii (homo sapiens) (aka fucosyltransferase 3 (lewis blood group))
F: None of the above. | B |
<Instruct>: Given the context 'Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.', select the correct biomedical concept corresponding to 'psgl-1'. Answer using one of the provided options. | <Options>: A: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
B: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
C: psgl-1 (homo sapiens) (aka selectin p ligand)
D: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
E: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
F: None of the above. | C |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept corresponding to '3-methyladenine-dna glycosylase'. Answer using one of the provided options. | <Options>: A: muty dna glycosylase (mus musculus) (aka muty dna glycosylase)
B: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
C: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: dna-3-methyladenine glycosylase 1-like (glycine max) (aka dna-3-methyladenine glycosylase 1-like)
E: thymine dna glycosylase (mus musculus) (aka thymine dna glycosylase)
F: None of the above. | B |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mp (mus musculus) (aka micropinna microphthalmia)
B: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
C: ppg (mus musculus) (aka glucagon)
D: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
E: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
F: None of the above. | B |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept corresponding to '3-methyladenine-dna glycosylase'. Answer using one of the provided options. | <Options>: A: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
B: thymine dna glycosylase (mus musculus) (aka thymine dna glycosylase)
C: 8-oxoguanine dna glycosylase (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: 8-oxoguanine dna-glycosylase 1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
E: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
F: None of the above. | A |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mgp (mus musculus) (aka matrix gla protein)
B: mp (mus musculus) (aka micropinna microphthalmia)
C: ppg (mus musculus) (aka glucagon)
D: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
E: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
F: None of the above. | E |
<Instruct>: Given the context 'In comparison, homologues of the Rad23 proteins (hHR23) and the hXPC protein are involved in the recognition of damaged bases in global genome repair, a subset of nucleotide excision repair.', select the correct biomedical concept corresponding to 'hxpc'. Answer using one of the provided options. | <Options>: A: hcph (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 6)
B: hppcn (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
C: hcypx (homo sapiens) (aka peptidylprolyl isomerase like 1)
D: hypc (homo sapiens) (aka pre-mrna processing factor 40b)
E: hypc (xenopus tropicalis) (aka pre-mrna processing factor 40 homolog a)
F: None of the above. | F |
<Instruct>: Given the context 'In comparison, homologues of the Rad23 proteins (hHR23) and the hXPC protein are involved in the recognition of damaged bases in global genome repair, a subset of nucleotide excision repair.', select the correct biomedical concept corresponding to 'hxpc'. Answer using one of the provided options. | <Options>: A: hcypx (homo sapiens) (aka peptidylprolyl isomerase like 1)
B: humpcp (homo sapiens) (aka prolylcarboxypeptidase)
C: hppcn (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
D: hypc (homo sapiens) (aka pre-mrna processing factor 40b)
E: hcph (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 6)
F: None of the above. | F |
<Instruct>: Given the context 'In this report, we show that the hHR23A and -B also interact with the MPG protein and can serve as accessory proteins for DNA damage recognition in base excision repair.', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
B: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
C: mgp (homo sapiens) (aka matrix gla protein)
D: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
E: mgp (mus musculus) (aka matrix gla protein)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, the MPG.hHR23 protein complex elevates the rate of MPG protein-catalyzed excision from hypoxanthine-containing substrates.', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mpg-1 (homo sapiens) (aka macrophage expressed 1)
B: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
C: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
D: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
E: ppg (mus musculus) (aka glucagon)
F: None of the above. | D |
<Instruct>: Given the context 'Furthermore, the MPG.hHR23 protein complex elevates the rate of MPG protein-catalyzed excision from hypoxanthine-containing substrates.', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
B: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
C: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
D: mgp (mus musculus) (aka matrix gla protein)
E: mp (mus musculus) (aka micropinna microphthalmia)
F: None of the above. | B |
<Instruct>: Given the context 'This increased excision rate is correlated with a greater binding affinity of the MPG protein-hHR23 protein complex for damaged DNA.', select the correct biomedical concept corresponding to 'mpg'. Answer using one of the provided options. | <Options>: A: mgp (mus musculus) (aka matrix gla protein)
B: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
C: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
D: mgp (homo sapiens) (aka matrix gla protein)
E: mp (mus musculus) (aka micropinna microphthalmia)
F: None of the above. | B |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept corresponding to 'htra2'. Answer using one of the provided options. | <Options>: A: htra2-beta (homo sapiens) (aka transformer 2 beta homolog)
B: htra2 (homo sapiens) (aka htra serine peptidase 2)
C: htr2 (homo sapiens) (aka 5-hydroxytryptamine receptor 2a)
D: htra serine peptidase 1 (homo sapiens) (aka htra serine peptidase 1)
E: htra serine peptidase 2 (sus scrofa) (aka htra serine peptidase 2)
F: None of the above. | B |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept corresponding to 'humhtra2'. Answer using one of the provided options. | <Options>: A: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
B: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
E: hthtr2 (homo sapiens) (aka solute carrier family 19 member 3)
F: None of the above. | F |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept corresponding to 'omi'. Answer using one of the provided options. | <Options>: A: omt (drosophila melanogaster) (aka rab1)
B: ommatidialess (drosophila melanogaster) (aka ommatidialess)
C: omi (homo sapiens) (aka htra serine peptidase 2)
D: om1 (mus musculus) (aka importin 8)
E: om (mus musculus) (aka ovum mutant)
F: None of the above. | C |
<Instruct>: Given the context 'In this report we describe the overexpression of humHtrA2 in two heterologous systems comparing the merits of each.', select the correct biomedical concept corresponding to 'humhtra2'. Answer using one of the provided options. | <Options>: A: ear2 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 6)
B: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
C: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
F: None of the above. | F |
<Instruct>: Given the context 'By means of fluorescently labeled substrates alpha- and beta-casein and zymography, the proteolytic activity of recombinant HumHtrA2 was also demonstrated.', select the correct biomedical concept corresponding to 'humhtra2'. Answer using one of the provided options. | <Options>: A: thralpha2 (homo sapiens) (aka thyroid hormone receptor alpha)
B: mxra2 (homo sapiens) (aka parvin alpha)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
E: ear2 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 6)
F: None of the above. | F |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: il22 (homo sapiens) (aka interleukin 22)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
E: il2 (homo sapiens) (aka interleukin 2)
F: None of the above. | E |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
D: il22 (homo sapiens) (aka interleukin 22)
E: interleukin 3 (homo sapiens) (aka interleukin 3)
F: None of the above. | F |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept corresponding to 'p21snft'. Answer using one of the provided options. | <Options>: A: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
B: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
C: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
D: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
E: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
F: None of the above. | B |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: interleukin 2 (homo sapiens) (aka interleukin 2)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
F: None of the above. | A |
<Instruct>: Given the context 'The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: il-2 (homo sapiens) (aka interleukin 2)
E: interleukin 3 (homo sapiens) (aka interleukin 3)
F: None of the above. | D |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept corresponding to 'p21snft'. Answer using one of the provided options. | <Options>: A: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
B: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
C: nft1 (saccharomyces cerevisiae s288c) (putative multidrug transporter nft1 (saccharomyces cerevisiae s288c)) (aka putative multidrug transporter nft1)
D: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
E: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
F: None of the above. | E |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: il-2 (homo sapiens) (aka interleukin 2)
E: interleukin 3 (homo sapiens) (aka interleukin 3)
F: None of the above. | D |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'p21snft'. Answer using one of the provided options. | <Options>: A: nft1 (saccharomyces cerevisiae s288c) (putative multidrug transporter nft1 (saccharomyces cerevisiae s288c)) (aka putative multidrug transporter nft1)
B: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
C: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
D: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
E: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
F: None of the above. | C |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: interleukin 2 (homo sapiens) (aka interleukin 2)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: interleukin 3 (homo sapiens) (aka interleukin 3)
D: il22 (homo sapiens) (aka interleukin 22)
E: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
F: None of the above. | A |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
D: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
E: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
F: None of the above. | A |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'fos'. Answer using one of the provided options. | <Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
C: fos (mus musculus) (aka fbj osteosarcoma oncogene)
D: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
E: fra (homo sapiens) (fos like 1, ap-1 transcription factor subunit (homo sapiens)) (aka fos like 1, ap-1 transcription factor subunit)
F: None of the above. | B |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: jun (mus musculus) (aka jun proto-oncogene)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
D: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
E: c-jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
F: None of the above. | E |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
D: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
E: None of the above. | E |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept corresponding to 'p21snft'. Answer using one of the provided options. | <Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
C: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
D: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
E: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
F: None of the above. | A |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
D: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
E: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
F: None of the above. | E |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: interleukin 2 (homo sapiens) (aka interleukin 2)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
F: None of the above. | C |
<Instruct>: Given the context 'Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
', select the correct biomedical concept corresponding to 'cxc-chemokine receptor 2'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
B: c-x-c motif chemokine receptor 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 2)
C: atypical chemokine receptor 2 (homo sapiens) (aka atypical chemokine receptor 2)
D: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
E: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: None of the above. | D |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | C |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept corresponding to 'il-8'. Answer using one of the provided options. | <Options>: A: ck-8 (homo sapiens) (aka keratin 8)
B: il18 (homo sapiens) (aka interleukin 18)
C: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
D: il1f8 (homo sapiens) (aka interleukin 36 beta)
E: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
F: None of the above. | C |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept corresponding to 'neutrophil-activating peptide 2'. Answer using one of the provided options. | <Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
C: gro2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
D: mip-2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
E: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
F: None of the above. | A |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept corresponding to 'nap-2'. Answer using one of the provided options. | <Options>: A: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: nac-2 (homo sapiens) (aka nacc family member 2)
D: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
E: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
F: None of the above. | B |
<Instruct>: Given the context 'Although CXCR-2 has been successfully cloned and expressed in several cell lines, the molecular properties of the native neutrophil-expressed receptor have remained largely undefined.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | C |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | C |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: None of the above. | C |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept corresponding to 'il-8'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
B: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
C: il18 (homo sapiens) (aka interleukin 18)
D: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: il1f8 (homo sapiens) (aka interleukin 36 beta)
F: None of the above. | A |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept corresponding to 'nap-2'. Answer using one of the provided options. | <Options>: A: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
B: nac-2 (homo sapiens) (aka nacc family member 2)
C: nap-2 (homo sapiens) (aka pro-platelet basic protein)
D: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
E: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
F: None of the above. | C |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | C |
<Instruct>: Given the context 'According to deglycosylation experiments surface-expressed CXCR-2 carries two N-linked 9-kDa carbohydrate moieties that are both of complex structure.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | B |
<Instruct>: Given the context 'In addition, two other CXCR-2 variants of 38 and 40 kDa were found to occur exclusively intracellular and to carry N-glycosylations of high mannose or hybrid type.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | A |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | B |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept corresponding to 'nap-2'. Answer using one of the provided options. | <Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
C: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
D: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
E: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
F: None of the above. | A |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | B |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept corresponding to 'nap-2'. Answer using one of the provided options. | <Options>: A: nabp2 (homo sapiens) (aka nucleic acid binding protein 2)
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
D: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
E: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
F: None of the above. | B |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | C |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: None of the above. | C |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | B |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept corresponding to '2p domain mechano-sensitive k+ channel'. Answer using one of the provided options. | <Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: potassium two pore domain channel subfamily k member 10 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: potassium two pore domain channel subfamily k member 4 (homo sapiens) (aka potassium two pore domain channel subfamily k member 4)
D: kcnk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: kcnc2 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 2)
F: None of the above. | B |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: None of the above. | D |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept corresponding to 'trek1'. Answer using one of the provided options. | <Options>: A: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
B: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
E: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | E |
<Instruct>: Given the context 'TREK2 is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | D |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | C |
<Instruct>: Given the context 'In transfected cells, TREK2 produces rapidly activating and non-inactivating outward rectifier K(+) currents.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | C |
<Instruct>: Given the context 'TREK2 is blocked by application of intracellular cAMP.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | B |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek1'. Answer using one of the provided options. | <Options>: A: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
B: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
E: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
F: None of the above. | B |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | C |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
E: None of the above. | E |
<Instruct>: Given the context 'TREK2 can be positively or negatively regulated by a variety of neurotransmitter receptors.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | D |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to '5ht4sr'. Answer using one of the provided options. | <Options>: A: 5-ht4r (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
B: htr4 (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
C: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
D: sstr4 (homo sapiens) (aka somatostatin receptor 4)
E: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
F: None of the above. | B |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'mglur1'. Answer using one of the provided options. | <Options>: A: mglur1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
B: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
C: mglu1 (homo sapiens) (aka glutamate metabotropic receptor 1)
D: metabotropic glutamate receptor 1 (xenopus tropicalis) (aka metabotropic glutamate receptor 1)
E: glur-1 (mus musculus) (aka glutamate receptor, ionotropic, ampa1 (alpha 1))
F: None of the above. | C |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'mglur2'. Answer using one of the provided options. | <Options>: A: glurr2 (homo sapiens) (aka polr2m pseudogene 1)
B: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
C: grm2 (homo sapiens) (aka glutamate metabotropic receptor 2)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: glur-2 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 2)
F: None of the above. | C |
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