instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: None of the above. | C |
<Instruct>: Given the context 'These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | D |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: None of the above. | C |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept corresponding to 'interleukin-6'. Answer using one of the provided options. | <Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: interleukin 6 (homo sapiens) (aka interleukin 6)
C: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: None of the above. | B |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'related adhesion focal tyrosine kinase'. Answer using one of the provided options. | <Options>: A: frk (drosophila melanogaster) (aka franklin)
B: fak (homo sapiens) (aka protein tyrosine kinase 2)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
E: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | E |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
D: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
E: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
F: None of the above. | B |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
B: frk (bos taurus) (aka fyn related src family tyrosine kinase)
C: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
D: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
E: frnk (homo sapiens) (aka protein tyrosine kinase 2)
F: None of the above. | F |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'pyk2'. Answer using one of the provided options. | <Options>: A: pyk2 (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
C: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
D: pyk2 (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
E: tyk2 (homo sapiens) (aka tyrosine kinase 2)
F: None of the above. | A |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'interleukin-6'. Answer using one of the provided options. | <Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
E: None of the above. | D |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: il6 (homo sapiens) (aka interleukin 6)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: None of the above. | A |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: frnk (homo sapiens) (aka protein tyrosine kinase 2)
C: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
D: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
E: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | E |
<Instruct>: Given the context 'However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: il6 (homo sapiens) (aka interleukin 6)
E: None of the above. | D |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: None of the above. | C |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: il-6 (homo sapiens) (aka interleukin 6)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | A |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
F: None of the above. | D |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
E: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
F: None of the above. | C |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
C: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
F: None of the above. | E |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
E: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
F: None of the above. | F |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
B: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
E: frk (drosophila melanogaster) (aka franklin)
F: None of the above. | C |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: frnk (homo sapiens) (aka protein tyrosine kinase 2)
C: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
D: frk (bos taurus) (aka fyn related src family tyrosine kinase)
E: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
F: None of the above. | A |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
E: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
F: None of the above. | C |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (drosophila melanogaster) (aka franklin)
B: frnk (homo sapiens) (aka protein tyrosine kinase 2)
C: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
D: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
E: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | E |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
D: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
F: None of the above. | A |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: il-6 (homo sapiens) (aka interleukin 6)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | C |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
F: None of the above. | C |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: interleukin 6 (homo sapiens) (aka interleukin 6)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | C |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
F: None of the above. | D |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
F: None of the above. | F |
<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept corresponding to 'alpha(2a) adrenoceptor'. Answer using one of the provided options. | <Options>: A: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
B: adrenoceptor alpha 2b (homo sapiens) (aka adrenoceptor alpha 2b)
C: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
D: adra2a (homo sapiens) (aka adrenoceptor alpha 2a)
E: None of the above. | D |
<Instruct>: Given the context 'Cells were transfected with a bicistronic plasmid containing the alpha2C10 and neomycin phosphotransferase genes.', select the correct biomedical concept corresponding to 'alpha2c10'. Answer using one of the provided options. | <Options>: A: adrenoceptor alpha 2c (homo sapiens) (aka adrenoceptor alpha 2c)
B: cyclic nucleotide gated channel subunit alpha 2 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 2)
C: integrin subunit alpha 10 (homo sapiens) (aka integrin subunit alpha 10)
D: cholinergic receptor nicotinic alpha 10 subunit (homo sapiens) (aka cholinergic receptor nicotinic alpha 10 subunit)
E: alpha2aar (homo sapiens) (aka adrenoceptor alpha 2a)
F: None of the above. | E |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'extracellular regulated protein kinase 1'. Answer using one of the provided options. | <Options>: A: mitogen-activated protein kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: erk-2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
D: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
E: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
F: None of the above. | C |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'erk1'. Answer using one of the provided options. | <Options>: A: p44-erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
B: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
D: erk8 (homo sapiens) (aka mitogen-activated protein kinase 15)
E: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
F: None of the above. | A |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'erk2'. Answer using one of the provided options. | <Options>: A: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
B: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
C: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
D: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
E: sapk2b (homo sapiens) (aka mitogen-activated protein kinase 11)
F: None of the above. | A |
<Instruct>: Given the context 'It was unaffected by protein kinase C downregulation but correlated with a transient increase in Shc tyrosine phosphorylation.', select the correct biomedical concept corresponding to 'shc'. Answer using one of the provided options. | <Options>: A: shca (homo sapiens) (aka shc adaptor protein 1)
B: shcc (homo sapiens) (aka shc adaptor protein 3)
C: shc adaptor protein 2 (homo sapiens) (aka shc adaptor protein 2)
D: None of the above. | A |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: il4 (bos taurus) (aka interleukin 4)
E: il-4 (homo sapiens) (aka interleukin 4)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
E: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
F: None of the above. | C |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ifn-induced protein of 10 kda'. Answer using one of the provided options. | <Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: ifi11 (homo sapiens) (aka immunity related gtpase m)
C: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: ifi-30 (homo sapiens) (aka ifi30 lysosomal thiol reductase)
E: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: interleukin 10 (homo sapiens) (aka interleukin 10)
D: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | F |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'monokine induced by ifn-gamma'. Answer using one of the provided options. | <Options>: A: midkine (homo sapiens) (aka midkine)
B: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
E: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
D: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
E: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ifn-inducible t-cell alpha-chemoattractant'. Answer using one of the provided options. | <Options>: A: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
B: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
C: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
D: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
E: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
F: None of the above. | B |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'cxcr3 receptor'. Answer using one of the provided options. | <Options>: A: chemokine (c-c motif) receptor 3 (xenopus tropicalis) (aka chemokine (c-c motif) receptor 3)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | C |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 4 (bos taurus) (aka interleukin 4)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il-4 (homo sapiens) (aka interleukin 4)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: None of the above. | D |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-10'. Answer using one of the provided options. | <Options>: A: interleukin 10 (bos taurus) (aka interleukin 10)
B: il-10a (homo sapiens) (aka interleukin 10)
C: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: il-10c (homo sapiens) (aka interleukin 19)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-17'. Answer using one of the provided options. | <Options>: A: il-17a (homo sapiens) (aka interleukin 17a)
B: interleukin 17c (homo sapiens) (aka interleukin 17c)
C: il-17 (bos taurus) (aka interleukin 17a)
D: interleukin 17f (homo sapiens) (aka interleukin 17f)
E: None of the above. | A |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: il-10c (homo sapiens) (aka interleukin 19)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | A |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
B: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
C: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
B: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
E: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
F: None of the above. | F |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: tac1 (homo sapiens) (aka tachykinin precursor 1)
C: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
D: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | D |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: il-4 (bos taurus) (aka interleukin 4)
B: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
C: il4 (homo sapiens) (aka interleukin 4)
D: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: None of the above. | C |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-10'. Answer using one of the provided options. | <Options>: A: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
B: il10 (homo sapiens) (aka interleukin 10)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: interleukin 10 (oryctolagus cuniculus) (aka interleukin 10)
E: interleukin 10 (bos taurus) (aka interleukin 10)
F: None of the above. | B |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-17'. Answer using one of the provided options. | <Options>: A: il-17f (homo sapiens) (aka interleukin 17f)
B: il-17c (homo sapiens) (aka interleukin 17c)
C: il-17 (homo sapiens) (aka interleukin 17a)
D: il-17 (bos taurus) (aka interleukin 17a)
E: None of the above. | C |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: ifn-gamma (gallus gallus) (aka interferon)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: interferon gamma (sus scrofa) (aka interferon gamma)
E: interferon gamma (xenopus tropicalis) (aka interferon gamma)
F: None of the above. | B |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'tnf-alpha'. Answer using one of the provided options. | <Options>: A: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
B: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
C: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
D: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
E: tnfa (homo sapiens) (aka tumor necrosis factor)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
C: il-10c (homo sapiens) (aka interleukin 19)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
B: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
B: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
C: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
D: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
E: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | F |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: il-10c (homo sapiens) (aka interleukin 19)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
C: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | A |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
F: None of the above. | D |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
D: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
E: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
F: None of the above. | A |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
B: ifn-gamma (gallus gallus) (aka interferon)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
E: interferon gamma (homo sapiens) (aka interferon gamma)
F: None of the above. | E |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: il4 (homo sapiens) (aka interleukin 4)
B: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
C: interleukin 4 (bos taurus) (aka interleukin 4)
D: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: None of the above. | A |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
C: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
E: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | E |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (xenopus tropicalis) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: interferon gamma (homo sapiens) (aka interferon gamma)
D: interferon gamma (sus scrofa) (aka interferon gamma)
E: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
F: None of the above. | C |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 4 (bos taurus) (aka interleukin 4)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: interleukin 4 (homo sapiens) (aka interleukin 4)
E: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
F: None of the above. | D |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: il-4 (bos taurus) (aka interleukin 4)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: None of the above. | F |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: ifn-gamma (gallus gallus) (aka interferon)
B: interferon gamma (sus scrofa) (aka interferon gamma)
C: interferon gamma (homo sapiens) (aka interferon gamma)
D: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
E: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
F: None of the above. | C |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: interleukin 4 (bos taurus) (aka interleukin 4)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il4 (homo sapiens) (aka interleukin 4)
E: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
F: None of the above. | D |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (mus musculus) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: interferon gamma (homo sapiens) (aka interferon gamma)
D: ifn-gamma (gallus gallus) (aka interferon)
E: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
F: None of the above. | C |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'tnf-alpha'. Answer using one of the provided options. | <Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
D: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
E: ifn-alpha (homo sapiens) (aka interferon alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
E: il-10c (homo sapiens) (aka interleukin 19)
F: None of the above. | C |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
B: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
E: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | C |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
E: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
F: None of the above. | B |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: None of the above. | A |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
E: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
F: None of the above. | A |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
B: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
D: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
E: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
F: None of the above. | A |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
B: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
D: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
E: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | F |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
F: None of the above. | E |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
B: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
E: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
F: None of the above. | A |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf (homo sapiens) (aka rho gtpase activating protein 26)
D: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
E: grap (homo sapiens) (aka grb2 related adaptor protein)
F: None of the above. | C |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
F: None of the above. | F |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept corresponding to 'rhoa'. Answer using one of the provided options. | <Options>: A: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
B: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
C: rhoa (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
D: rhoa-a (xenopus laevis) (ras homolog family member a l homeolog (xenopus laevis)) (aka ras homolog family member a l homeolog)
E: rhoa (homo sapiens) (aka ras homolog family member a)
F: None of the above. | F |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: grap (homo sapiens) (aka grb2 related adaptor protein)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
E: graf (homo sapiens) (aka rho gtpase activating protein 26)
F: None of the above. | E |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
E: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
F: None of the above. | D |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
C: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
D: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
E: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
F: None of the above. | C |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | A |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | F |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
E: lec1 (drosophila melanogaster) (aka parched)
F: None of the above. | B |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccr1'. Answer using one of the provided options. | <Options>: A: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
E: None of the above. | D |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccr8'. Answer using one of the provided options. | <Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
F: None of the above. | D |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'liver-expressed chemokine'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
B: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
C: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
E: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
F: None of the above. | F |
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