instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'MDC9 can be both cell surface biotinylated and 125I-labeled in NIH 3T3 mouse fibroblasts, indicating that the protein is present on the plasma membrane.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: mdc9 (homo sapiens) (aka adam metallopeptida... | D |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of t... | <Options>: A: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) ... | A |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of t... | <Options>: A: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homo... | C |
<Instruct>: Given the context 'The apparent molecular mass of 84 kD suggests that MDC9 contains a membrane-anchored metalloprotease and disintegrin domain.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with... | C |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
C: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptida... | C |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: mdc15 (hom... | B |
<Instruct>: Given the context 'A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
B: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
D: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
E: glra1 (homo sapiens) (aka glycine receptor alpha 1)
... | E |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glycine receptor (glyr) alpha 1'. Answer using one of the provided options. | <Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: cg-alpha-1 (glycine max) (aka beta-conglycinin, alpha chain-like)
D: glycine receptor alpha 1 (xenopus tropicalis) (aka ... | E |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glycine receptor (glyr) alpha 1'. Answer using one of the provided options. | <Options>: A: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
C: glyr1 (homo sapiens) (aka glyoxylate reductase ... | F |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (homo sapiens) (aka glycine receptor alpha 1)
B: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
C: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
D: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
E: glutamate receptor 1.1-like (glycine max) (aka glutamate... | A |
<Instruct>: Given the context 'In a recessive case of hyperekplexia, we found a deletion of exons 1-6 of the GLRA1 gene.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra2 (homo sapiens) (aka glycine receptor alpha 2)
B: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
E: glra1 (homo sapiens) (aka glycine receptor alpha 1)
F: Non... | E |
<Instruct>: Given the context 'Born to consanguineous parents, the affected child is homozygous for this GLRA1(null) allele consistent with a complete loss of gene function.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
B: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
C: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
D: glra1 (homo sapiens) (aka glycine receptor alpha 1)
E: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l home... | D |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'glra1'. Answer using on... | <Options>: A: glr1.1 (arabidopsis thaliana) (aka glutamate receptor 1.1)
B: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
C: glra1 (homo sapiens) (aka glycine receptor alpha 1)
D: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
E: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)... | C |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'spd'. Answer using one ... | <Options>: A: spdyc (homo sapiens) (aka speedy/ringo cell cycle regulator family member c)
B: spdt (homo sapiens) (aka spondyloepiphyseal dysplasia tarda, autosomal dominant)
C: spdy1 (homo sapiens) (aka speedy/ringo cell cycle regulator family member a)
D: spdl1 (homo sapiens) (aka spindle apparatus coiled-coil protei... | F |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'ot'. Answer using one o... | <Options>: A: otr (drosophila melanogaster) (aka octopamine-tyramine receptor)
B: otp (oryctolagus cuniculus) (aka orthopedia homeobox)
C: ot (drosophila melanogaster) (aka outheld)
D: otr (homo sapiens) (aka oxytocin receptor)
E: otof (oryctolagus cuniculus) (aka otoferlin)
F: None of the above. | F |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'glyr alpha 1'. Answer u... | <Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
C: glyr-a1 (xenopus tropicalis) (aka glycine receptor alpha 1)
D: alpha1aar (homo sapiens) (aka adrenoceptor a... | B |
<Instruct>: Given the context 'Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
', select the correct biomedical concept corresponding to 'apo-2 ligand'. Answer using one of the provided options. | <Options>: A: apo-l (homo sapiens) (aka apolipoprotein l1)
B: fas ligand (homo sapiens) (aka fas ligand)
C: cd40 ligand (homo sapiens) (aka cd40 ligand)
D: apo2l (homo sapiens) (aka tnf superfamily member 10)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | D |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2 ligand'. Answer using one of the provided options. | <Options>: A: trail (homo sapiens) (aka tnf superfamily member 10)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: fas ligand (homo sapiens) (aka fas ligand)
D: apo-l (homo sapiens) (aka apolipoprotein l1)
E: cd40 ligand (homo sapiens) (aka cd40 ligand)
F: None of the above. | A |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: tall-2 (homo sapiens) (aka tnf superfamily member 13)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: cd95l (homo sapiens) (aka fas ligand)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | B |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: tall2 (homo sapiens) (aka tnf superfamily member 13)
D: cd95l (homo sapiens) (aka fas ligand)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | F |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: trail (homo sapiens) (aka tnf superfamily member 10)
C: cd95-l (homo sapiens) (aka fas ligand)
D: tall2 (homo sapiens) (aka tnf superfamily member 13)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: None of the above. | B |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
C: fas-as (homo sapiens) (aka fas antisense rna 1)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F... | B |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
B: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
C: apo-1 (homo sapiens) (aka fas cell surface death receptor)
D: apol-i (homo sapiens) (aka apolipoprotein l1)
E: cd40 ligand (homo sapiens) (aka cd40 ligand)
F: Non... | C |
<Instruct>: Given the context 'Transfected Apo-2L is expressed at the cell surface with its C terminus exposed, indicating a type II transmembrane protein topology.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo3l (homo sapiens) (aka tnf superfamily member 12)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: cd95-l (homo sapiens) (aka fas ligand)
D: apol2 (homo sapiens) (aka apolipoprotein l2)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | B |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: fasas (homo sapiens) (aka fas antisense rna 1)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threon... | A |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: cd40 ligand (homo sapiens) (aka cd40 ligand)
B: trail (homo sapiens) (aka tnf superfamily member 10)
C: apo-1 (homo sapiens) (aka fas cell surface death receptor)
D: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
E: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)... | C |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: cd95l (homo sapiens) (aka fas ligand)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | C |
<Instruct>: Given the context 'Soluble Apo-2L induces extensive apoptosis in lymphoid as well as non-lymphoid tumor cell lines.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: cd95-l (homo sapiens) (aka fas ligand)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: tall2 (homo sapiens) (aka tnf superfamily member 13)
E: apo2l (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | E |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo3l (homo sapiens) (aka tnf superfamily member 12)
B: cd95l (homo sapiens) (aka fas ligand)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: tall-2 (homo sapiens) (aka tnf superfamily member 13)
E: apo-2l (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | E |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
C: fasps (homo sapiens) (aka period circadian regulator 2)
D: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surf... | D |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fasn (homo sapiens) (aka fatty acid synthase)
C: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
D: fas-as (homo sapiens) (aka fas antisense rna 1)
E: fasps (homo sapiens) (a... | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: apof (homo sapiens) (aka apolipoprotein f)
C: apol-i (homo sapiens) (aka apolipoprotein l1)
D: trail (homo sapiens) (aka tnf superfamily member 10)
E: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
F: None of the above. | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
B: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
C: fasas (homo sapiens) (aka fas antisense rna 1)
D: fas (gallus gallus) (aka fas cell surface death r... | E |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
B: cd951 (homo sapiens) (aka fas cell surface death receptor)
C: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
D: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
E: trail (homo sapiens) (aka tnf su... | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fasn (homo sapiens) (aka fatty acid synthase)
C: fasps (homo sapiens) (aka period circadian regulator 2)
D: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
E: fas (homo sapie... | E |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: trail (homo sapiens) (aka tnf superfamily member 10)
B: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
C: apof (homo sapiens) (aka apolipoprotein f)
D: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
E: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
F: None of th... | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apol2 (homo sapiens) (aka apolipoprotein l2)
C: apo2l (homo sapiens) (aka tnf superfamily member 10)
D: tall2 (homo sapiens) (aka tnf superfamily member 13)
E: cd95-l (homo sapiens) (aka fas ligand)
F: None of the above. | C |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo-2l (homo sapiens) (aka tnf superfamily member 10)
B: cd95l (homo sapiens) (aka fas ligand)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: tall-2 (homo sapiens) (aka tnf superfamily member 13)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: None of the above. | A |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: fas-as (homo sapiens) (aka fas antisense rna 1)
D: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threon... | A |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: apof (homo sapiens) (aka apolipoprotein f)
C: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
D: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
E: apol-i (homo sapiens) (aka apolipoprotein l1)
F: None of the above. | F |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
C: fasn (homo sapiens) (aka fatty acid synthase)
D: fasps (homo sapiens) (aka period circadian regul... | A |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fas-as (homo sapiens) (aka fas antisense rna 1)
E: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas ac... | F |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: apol1 (homo sapiens) (aka apolipoprotein l1)
B: cd40 ligand (homo sapiens) (aka cd40 ligand)
C: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
D: fas ligand (homo sapiens) (aka fas ligand)
E: apo-1 (homo sapiens) (aka fas cell surface death receptor)
F: None of the above. | E |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: cd95-l (homo sapiens) (aka fas ligand)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: None of the above. | B |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept corresponding to 'polypeptide n-acetylgalactosaminyltransferase, galnac-t3'. Answer using one of the provided options. | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (caenorhabditis elegans) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: galnac-t3 (homo sapiens) (aka polypeptide n-acetyl... | C |
<Instruct>: Given the context 'Here we report the cDNA cloning and expression of a novel GalNAc-transferase termed GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (... | D |
<Instruct>: Given the context 'The overall amino acid sequence similarity with GalNAc-T1 and -T2 is approximately 45%; 12 cysteine residues that are shared between GalNAc-T1 and -T2 are also found in GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided option... | <Options>: A: galnt3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylg... | D |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the cor... | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypeptide n-acetylgalactosam... | B |
<Instruct>: Given the context 'Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
C: galnac-t3 (homo sapiens) (aka pol... | C |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5a (homo sapiens) (aka eukaryotic trans... | E |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: eif-5a (homo sapiens) (eukaryotic translation initiation factor 5 (homo sapiens)) (aka eukaryotic translati... | C |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-5)
C: eif-5 (homo sapiens) (aka eukaryotic translation initiation fact... | C |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation fa... | F |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka euka... | E |
<Instruct>: Given the context 'In this paper, the multiple mRNAs that encode mammalian eIF-5 have been characterized.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
D: eukar... | B |
<Instruct>: Given the context 'In rat tissues, three major eIF-5 mRNAs of 3.5, 2.8, and 2.2 kilobases in length are detected.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor... | E |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept corresponding to 'eif-5'. Answer ... | <Options>: A: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
... | A |
<Instruct>: Given the context 'The different lengths of the 3'-untranslated region of eIF-5 mRNAs are generated by the use of alternative polyadenylation signals.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
... | A |
<Instruct>: Given the context 'Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
D: eukaryotic t... | B |
<Instruct>: Given the context 'These results should lead to increased understanding of the regulation of eIF-5 gene expression.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene... | E |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer usi... | <Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: casp-8 (homo sapiens) (aka caspase 8)
C: ice-lap6 (xenopus tropicalis) (aka caspase 9)
D: ice-lap6 (mus musculus) (aka caspase 9)
E: ice-lap3 (homo sapiens) (aka caspase 7)
F: None of the above. | A |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept corresponding to 'granzyme b'. Answer u... | <Options>: A: granzyme b (bos taurus) (aka granzyme b)
B: granzyme b (oryctolagus cuniculus) (aka granzyme b)
C: granzyme b (homo sapiens) (aka granzyme b)
D: granzyme b, pseudogene 2 (rattus norvegicus) (aka granzyme b, pseudogene 2)
E: granzyme b (mus musculus) (aka granzyme b)
F: None of the above. | C |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: caspase-6 (homo sapiens) (aka caspase 6)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice-lap3 (homo sapiens) (aka caspase 7)
F: None of the above. | C |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: caspase-6 (homo sapiens) (aka caspase 6)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: casp-7 (homo sapiens) (aka caspase 7)
E: ice-lap6 (xenopus tropicalis) (aka caspase 9)
F: None of the above. | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: casp-7 (homo sapiens) (aka caspase 7)
D: casp-8 (homo sapiens) (aka caspase 8)
E: caspase-6 (homo sapiens) (aka caspase 6)
F: None of the above. | B |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'yama'. Answer using one of the provided options. | <Options>: A: yama (rattus norvegicus) (aka caspase 3)
B: death executioner caspase related to apopain/yama (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
C: chica (homo sapiens) (aka family with sequence similarity 83 member d)
D: yama (mus musculus) (aka caspase 3)
E: yam1 (homo sap... | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'cpp32'. Answer using one of the provided options. | <Options>: A: cpp32 (homo sapiens) (aka caspase 3)
B: hcp32 (homo sapiens) (aka cycs pseudogene 32)
C: esp32 (homo sapiens) (aka colipase like 1)
D: pp32 (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
E: spgf32 (homo sapiens) (aka spermatogenesis and oogenesis specific basic helix-loop-helix 1)
F... | A |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'apopain'. Answer using one of the provided options. | <Options>: A: aponp (homo sapiens) (aka apolipoprotein n, pseudogene)
B: apopain (xenopus tropicalis) (aka caspase 3, gene 2)
C: apop1 (homo sapiens) (aka cytochrome c oxidase assembly factor 8)
D: apon (rattus norvegicus) (aka apolipoprotein n)
E: apoh (homo sapiens) (aka apolipoprotein h)
F: None of the above. | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'mch2'. Answer using one of the provided options. | <Options>: A: mch2 (mus musculus) (aka caspase 6)
B: mch3 (homo sapiens) (aka caspase 7)
C: mch2r (homo sapiens) (aka melanin concentrating hormone receptor 2)
D: hmcn2 (homo sapiens) (aka hemicentin 2)
E: None of the above. | E |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'ice-lap3'. Answer using one of the provided options. | <Options>: A: apaf-3 (homo sapiens) (aka caspase 9)
B: casp-7 (homo sapiens) (aka caspase 7)
C: caspase 3 (homo sapiens) (aka caspase 3)
D: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
E: ice-lap3 (xenopus tropicalis) (aka caspase 7)... | B |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'mch3'. Answer using one of the provided options. | <Options>: A: transient receptor potential cation channel subfamily c member 3 (homo sapiens) (aka transient receptor potential cation channel subfamily c member 3)
B: ligand-gated chloride channel homolog 3 (drosophila melanogaster) (aka ligand-gated chloride channel homolog 3)
C: mch6 (homo sapiens) (aka caspase 9)
D... | E |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'cmh-1'. Answer using one of the provided options. | <Options>: A: cmg-1 (homo sapiens) (aka intraflagellar transport 74)
B: cmh-1 (homo sapiens) (aka caspase 7)
C: mlh-1 (homo sapiens) (aka mutl homolog 1)
D: mch-1r (homo sapiens) (aka melanin concentrating hormone receptor 1)
E: hcam-1 (homo sapiens) (aka phosphodiesterase 1a)
F: None of the above. | B |
<Instruct>: Given the context 'Interestingly, ICE-LAP6 contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap3 (homo sapiens) (aka caspase 7)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: caspase 6 (homo sapiens) (aka caspase 6)
E: ice-lap6 (xenopus tropicalis) (aka caspase 9)
F: None of the above. | B |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: casp-7 (homo sapiens) (aka caspase 7)
D: ice-lap6 (mus musculus) (aka caspase 9)
E: casp-8 (homo sapiens) (aka caspase 8)
F: None of the above. | A |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: caspase-6 (homo sapiens) (aka caspase 6)
C: ice-lap3 (homo sapiens) (aka caspase 7)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: casp-8 (homo sapiens) (aka caspase 8)
F: None of the above. | F |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: casp6 (homo sapiens) (aka caspase 6)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: ice-lap6 (homo sapiens) (aka caspase 9)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene)
F: None of the above. | D |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept corresponding to 'granzyme b'. Answer using one of the provided options. | <Options>: A: granzyme b (rattus norvegicus) (aka granzyme b)
B: granzyme h (homo sapiens) (aka granzyme h)
C: granzyme b-like (rattus norvegicus) (aka granzyme b-like)
D: granzyme b (homo sapiens) (aka granzyme b)
E: granzyme b (oryctolagus cuniculus) (aka granzyme b)
F: None of the above. | D |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: ice-lap6 (xenopus tropicalis) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: casp-7 (homo sapiens) (aka caspase 7)
F: None of the above. | A |
<Instruct>: Given the context 'Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options. | <Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E: neuropeptides b and w... | F |
<Instruct>: Given the context 'We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: mcop2 (homo sapiens) (aka visual system homeobox 2)
B: bmch2 (mus musculus) (aka bone mechanical trait 2)
C: mc2 (homo sapiens) (aka melanocortin 5 receptor)
D: b cell maturation defect 2 (mus musculus) (aka b cell maturation defect 2)
E: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor,... | F |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corr... | <Options>: A: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: cannabinoid receptor 2 (homo sapiens) (aka... | D |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corr... | <Options>: A: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
B: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
C: cpeb2 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 2)
D: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
E: hcn2 (homo sapiens) (aka h... | F |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corr... | <Options>: A: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
B: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
C: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sod... | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Options>: A: bmch2 (mus musculus) (aka bone mechanical trait 2)
B: bmc2 (mus musculus) (aka bone mineral content 2)
C: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
D: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
E: mcop2 (homo sapiens) (aka visual s... | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
C: bmch2 (mus musculus) (aka bone mechanical trait 2)
D: mcop2 (homo sapiens) (aka visual system homeobox 2)
E: mc2 (homo sapiens) (aka melanocortin 5 receptor)
F: None of the ... | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Options>: A: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
B: bmch2 (mus musculus) (aka bone mechanical trait 2)
C: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
D: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
E: mbc2 (mus mus... | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Options>: A: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
B: csnb2b (homo sapiens) (aka calcium binding protein 4)
C: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
D: basal cell carcinoma, susceptibility to, 2 (homo sapiens... | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Options>: A: cb1 (homo sapiens) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | A |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept corresponding to 'hcb2'. Answer using one of the provided options. | <Options>: A: csnb2b (homo sapiens) (aka calcium binding protein 4)
B: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
C: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
D: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
E: cpeb2... | F |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
B: mcop2 (homo sapiens) (aka visual system homeobox 2)
C: mbc2 (mus musculus) (aka extended synaptotagmin-like protein 1)
D: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
E: secretoglobin, family 2b, member 2 ... | F |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options. | <Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: cb1 (homo sapiens) (aka cannabinoid receptor 1)
C: cb1a (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | B |
<Instruct>: Given the context 'The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
', select the correct biomedical concept corresponding to 'glycine receptor beta'. Answer using one of the provided options. | <Options>: A: glycine receptor beta (xenopus tropicalis) (aka glycine receptor beta)
B: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
C: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
D: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)... | C |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: glrb (homo sapiens) (aka glycine receptor beta)
D: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
E: glyb (homo sapiens) (aka solute carrier family 25 ... | C |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Options>: A: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: glycine receptor beta (bos taurus) (aka glycine receptor beta)
D: glrb (homo sapiens) (aka glycine receptor beta)
E: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
F: ... | D |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
E: gprc2b (homo sapiens) (aka vomeronasa... | A |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
C: glyr1 (homo sapiens) (aka glyoxylate reductase ... | E |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Options>: A: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
B: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
C: glyr-a1 (xenopus laevis) (glycine receptor alph... | F |
<Instruct>: Given the context 'Neither [3H]strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: glycine receptor beta (bos ta... | A |
<Instruct>: Given the context 'However, co-expression of the beta subunit cDNA with the alpha 1 subunit cDNA resulted in expression of functional GlyRs which showed a 4-fold reduction in the EC50 values when compared to alpha 1 homomeric GlyRs.', select the correct biomedical concept corresponding to 'alpha 1 homomeric... | <Options>: A: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
B: gpr1as (homo sapiens) (aka cmklr2 antisense rna)
C: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
D: glycine receptor, alpha 1 (rattus norvegicus) (aka glyc... | C |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept correspondin... | <Options>: A: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
B: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
C: glyrs (homo sapiens) (aka glycyl-trna synthetase 1)
D: glycine receptor, alpha 1 (rattus norvegicus) (aka g... | B |
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