instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: glrb (homo sapiens) (aka glycine receptor beta)
F: None of the above. | E |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept corresponding to 'glrb'. Answer using one of the provided options. | <Options>: A: glrb (sus scrofa) (aka glycine receptor beta)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: glrb (xenopus tropicalis) (aka glycine receptor beta)
D: glrb (mus musculus) (aka glycine receptor, beta subunit)
E: glrb (rattus norvegicus) (aka glycine receptor, beta)
F: None of the above. | B |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: glycine receptor beta (bos taurus) (aka glycine receptor beta)
F: None of the above. | C |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
B: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
E: glycine receptor beta (bos taurus) (aka glycine receptor beta)
F: None of the above. | F |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glrb'. Answer using one of the provided options. | <Options>: A: glrb (homo sapiens) (aka glycine receptor beta)
B: gl-r (homo sapiens) (aka glucagon receptor)
C: glrb (bos taurus) (aka glycine receptor beta)
D: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
E: glrb (mus musculus) (aka glycine receptor, beta subunit)
F: None of the above. | E |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spastic'. Answer using one of the provided options. | <Options>: A: spn-4 (caenorhabditis elegans) (aka rrm domain-containing protein)
B: spastic paraplegia 14 (autosomal recessive) (homo sapiens) (aka spastic paraplegia 14 (autosomal recessive))
C: spasm (homo sapiens) (aka kantr integral membrane protein)
D: spastic (mus musculus) (aka glycine receptor, beta subunit)
E: spastic paraplegia 7 (pure and complicated autosomal recessive) (xenopus tropicalis) (aka spastic paraplegia 7 (pure and complicated autosomal recessive))
F: None of the above. | D |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spaii (homo sapiens) (aka surfactant protein a2)
B: spap (homo sapiens) (aka pdzk1 interacting protein 1)
C: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
D: spalpha (homo sapiens) (aka cd5 molecule like)
E: spap1a (homo sapiens) (aka fc receptor like 2)
F: None of the above. | F |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spalpha (homo sapiens) (aka cd5 molecule like)
B: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
C: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
D: spap (homo sapiens) (aka pdzk1 interacting protein 1)
E: spast.s (xenopus laevis) (aka spastin s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
B: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: glycine receptor beta (bos taurus) (aka glycine receptor beta)
E: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
F: None of the above. | F |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spast.s (xenopus laevis) (aka spastin s homeolog)
B: spap (homo sapiens) (aka pdzk1 interacting protein 1)
C: spas1 (homo sapiens) (aka spermatogenesis associated 19)
D: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
E: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
F: None of the above. | F |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cdc16 (homo sapiens) (aka cell division cycle 16)
D: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
E: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
F: None of the above. | B |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: hcp26 (homo sapiens) (aka cycs pseudogene 26)
D: cdc6 (homo sapiens) (aka cell division cycle 6)
E: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
F: None of the above. | B |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'mcm5'. Answer using one of the provided options. | <Options>: A: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna replication licensing factor mcm-5)
B: mcm5 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
D: cdc5 (homo sapiens) (aka cell division cycle 5 like)
E: mcm5 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
F: None of the above. | B |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
D: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
E: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
F: None of the above. | C |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept corresponding to 'mcm5'. Answer using one of the provided options. | <Options>: A: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
B: mcm5 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
C: mcm5 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: mcm6 (homo sapiens) (aka minichromosome maintenance complex component 6)
E: cdc5 (homo sapiens) (aka cell division cycle 5 like)
F: None of the above. | B |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cdc16 (homo sapiens) (aka cell division cycle 16)
B: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
E: cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
F: None of the above. | C |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
B: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
C: cdc16 (homo sapiens) (aka cell division cycle 16)
D: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
E: p1-cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
F: None of the above. | E |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cdc6 (homo sapiens) (aka cell division cycle 6)
B: ccdc46 (homo sapiens) (aka centrosomal protein 112)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle 26 (homo sapiens) (aka cell division cycle 26)
B: cdc16 (homo sapiens) (aka cell division cycle 16)
C: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
D: hcp26 (homo sapiens) (aka cycs pseudogene 26)
E: cdc6 (homo sapiens) (aka cell division cycle 6)
F: None of the above. | F |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
B: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
C: cdc6 (homo sapiens) (aka cell division cycle 6)
D: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
E: hcp26 (homo sapiens) (aka cycs pseudogene 26)
F: None of the above. | A |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: cdc6 (homo sapiens) (aka cell division cycle 6)
F: None of the above. | B |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'p1mcm3'. Answer using one of the provided options. | <Options>: A: mcm3 (xenopus tropicalis) (putative ortholog of dna replication licensing factor mcm3 (xenopus tropicalis)) (aka putative ortholog of dna replication licensing factor mcm3)
B: p1 (mus musculus) (minichromosome maintenance complex component 3 (mus musculus)) (aka minichromosome maintenance complex component 3)
C: p1.1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 7)
D: cnnm3 (mus musculus) (aka cyclin m3)
E: p1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 3)
F: None of the above. | E |
<Instruct>: Given the context 'We report herein the presence of kappa opioid receptors (KORs) in human fetal microglia and inhibition of HIV-1 expression in acutely infected microglial cell cultures treated with KOR ligands.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: kor (mus musculus) (aka opioid receptor, kappa 1)
D: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: kor1 (homo sapiens) (aka opioid receptor kappa 1)
F: None of the above. | E |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: oprk (homo sapiens) (aka opioid receptor kappa 1)
B: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: kor (mus musculus) (aka opioid receptor, kappa 1)
D: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
E: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
F: None of the above. | A |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
C: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
D: kor (homo sapiens) (aka opioid receptor kappa 1)
E: kor (mus musculus) (aka opioid receptor, kappa 1)
F: None of the above. | D |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: kor (mus musculus) (aka opioid receptor, kappa 1)
C: kor1 (homo sapiens) (aka opioid receptor kappa 1)
D: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
E: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'This antiviral effect of the kappa ligands was blocked by the specific KOR antagonist, nor-binaltrophimine.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
D: oprk (homo sapiens) (aka opioid receptor kappa 1)
E: kor (mus musculus) (aka opioid receptor, kappa 1)
F: None of the above. | D |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'p97 subunit of the 26s proteasome'. Answer using one of the provided options. | <Options>: A: rp97 (homo sapiens) (aka von willebrand factor a domain containing 8)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
F: None of the above. | D |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor-receptor-associated protein-2'. Answer using one of the provided options. | <Options>: A: trap2 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
C: tnf receptor associated factor 2 (homo sapiens) (aka tnf receptor associated factor 2)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: tram2 (homo sapiens) (aka translocation associated membrane protein 2)
F: None of the above. | A |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor-receptor-associated protein-2'. Answer using one of the provided options. | <Options>: A: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
B: rad51 associated protein 2 (homo sapiens) (aka rad51 associated protein 2)
C: tnf receptor associated factor 2 (homo sapiens) (aka tnf receptor associated factor 2)
D: tram2 (homo sapiens) (aka translocation associated membrane protein 2)
E: inositol 1,4,5-triphosphate receptor associated 2 (homo sapiens) (aka inositol 1,4,5-triphosphate receptor associated 2)
F: None of the above. | F |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to '55.11'. Answer using one of the provided options. | <Options>: A: p-55 (homo sapiens) (aka peptidase, mitochondrial processing subunit alpha)
B: cancer/testis antigen 55 (homo sapiens) (aka cancer/testis antigen 55)
C: gm5511 (mus musculus) (aka predicted gene 5511)
D: gp55 (homo sapiens) (aka neuroplastin)
E: hel55 (homo sapiens) (aka heat shock protein family b (small) member 6)
F: None of the above. | F |
<Instruct>: Given the context 'Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of 4.94.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: map97 (homo sapiens) (aka melanotransferrin)
C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
E: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
F: None of the above. | A |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
D: map97 (homo sapiens) (aka melanotransferrin)
E: p97 (bos taurus) (aka valosin containing protein)
F: None of the above. | B |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2'. Answer using one of the provided options. | <Options>: A: trap2 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
C: trap (homo sapiens) (tnf receptor associated factor 2 (homo sapiens)) (aka tnf receptor associated factor 2)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: tra1p2 (homo sapiens) (aka heat shock protein 90 beta family member 3, pseudogene)
F: None of the above. | A |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
C: map97 (homo sapiens) (aka melanotransferrin)
D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | E |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'nas1'. Answer using one of the provided options. | <Options>: A: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
B: nars (homo sapiens) (aka asparaginyl-trna synthetase 1)
C: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
D: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
E: nas2 (homo sapiens) (aka solute carrier family 13 member 4)
F: None of the above. | A |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'non-atpase subunit 1'. Answer using one of the provided options. | <Options>: A: nonu-1 (caenorhabditis elegans) (aka smr domain-containing protein)
B: ncph1 (homo sapiens) (aka deoxyguanosine kinase)
C: nonop1 (homo sapiens) (aka non-pou domain containing, octamer-binding pseudogene 1)
D: nono-1 (caenorhabditis elegans) (aka nops domain-containing protein;rrm domain-containing protein)
E: nop protein chaperone 1 (homo sapiens) (aka nop protein chaperone 1)
F: None of the above. | F |
<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept corresponding to 'nas1'. Answer using one of the provided options. | <Options>: A: nars (homo sapiens) (aka asparaginyl-trna synthetase 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
D: nas2 (homo sapiens) (aka solute carrier family 13 member 4)
E: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
F: None of the above. | B |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | E |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: p97 (bos taurus) (aka valosin containing protein)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
F: None of the above. | D |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: map97 (homo sapiens) (aka melanotransferrin)
D: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
E: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
F: None of the above. | F |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nas2p (saccharomyces cerevisiae s288c) (aka nas2p)
B: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
C: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
D: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
E: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
F: None of the above. | E |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
B: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
C: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
D: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
E: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
F: None of the above. | D |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: None of the above. | B |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
D: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
E: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
F: None of the above. | D |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | A |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'transforming growth factor-beta'. Answer using one of the provided options. | <Options>: A: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
D: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
E: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth factor beta receptor 3)
F: None of the above. | C |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
D: tgfb (homo sapiens) (aka transforming growth factor beta 1)
E: None of the above. | D |
<Instruct>: Given the context 'TGF-beta-related factors, including BMP-2/4, Dpp and activin, act through two types of serine/threonine kinase receptors which can form a heteromeric complex.', select the correct biomedical concept corresponding to 'dpp'. Answer using one of the provided options. | <Options>: A: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
B: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
C: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
D: dpp1 (homo sapiens) (aka cathepsin c)
E: None of the above. | E |
<Instruct>: Given the context 'In Drosophila, Mad is required for signalling by Dpp.', select the correct biomedical concept corresponding to 'dpp'. Answer using one of the provided options. | <Options>: A: dpp7 (homo sapiens) (aka dipeptidyl peptidase 7)
B: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
C: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
D: dpp1 (homo sapiens) (aka cathepsin c)
E: None of the above. | E |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
B: smad family member 4 (homo sapiens) (aka smad family member 4)
C: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
D: mamdc4 (homo sapiens) (aka mam domain containing 4)
E: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
F: None of the above. | B |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
D: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
E: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
F: None of the above. | F |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'dpc-4'. Answer using one of the provided options. | <Options>: A: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: protein madd-4 (caenorhabditis elegans) (aka protein madd-4)
D: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
E: defective pharyngeal development protein 4 (caenorhabditis elegans) (aka defective pharyngeal development protein 4)
F: None of the above. | B |
<Instruct>: Given the context 'hMAD-3 and -4 synergized to induce strong ligand-independent TGF-beta-like responses.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | C |
<Instruct>: Given the context 'When truncated at their carboxy termini, hMAD-3 and -4 act as dominant-negative inhibitors of the normal TGF-beta response.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgfbeta (homo sapiens) (aka transforming growth factor beta 1)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: None of the above. | A |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
D: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
E: None of the above. | D |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'hmad-3'. Answer using one of the provided options. | <Options>: A: hmad-3 (homo sapiens) (aka smad family member 3)
B: dmhdac3 (drosophila melanogaster) (aka histone deacetylase 3)
C: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
D: mamdc3 (homo sapiens) (aka mam domain containing glycosylphosphatidylinositol anchor 1)
E: hmad-2 (homo sapiens) (aka smad family member 2)
F: None of the above. | A |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
C: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
D: madh4 (homo sapiens) (aka smad family member 4)
E: mamdc4 (homo sapiens) (aka mam domain containing 4)
F: None of the above. | D |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: None of the above. | A |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'dpca-4'. Answer using one of the provided options. | <Options>: A: spindle assembly abnormal protein 4 (caenorhabditis elegans) (aka spindle assembly abnormal protein 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: d-sas-4 (drosophila melanogaster) (aka spindle assembly abnormal 4)
D: cell division cycle associated 4 (xenopus tropicalis) (aka cell division cycle associated 4)
E: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
F: None of the above. | B |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: madh4 (homo sapiens) (aka smad family member 4)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
D: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
E: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
F: None of the above. | A |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept corresponding to 'c5a chemoattractant receptor'. Answer using one of the provided options. | <Options>: A: c5ar (mus musculus) (aka complement component 5a receptor 1)
B: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
C: complement c5a receptor 1 (homo sapiens) (aka complement c5a receptor 1)
D: c5ar1 (bos taurus) (aka complement c5a receptor 1)
E: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept corresponding to 'c5a chemoattractant receptor'. Answer using one of the provided options. | <Options>: A: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
B: c5ar1 (bos taurus) (aka complement c5a receptor 1)
C: c5ar1 (mus musculus) (aka complement component 5a receptor 1)
D: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
E: None of the above. | E |
<Instruct>: Given the context 'A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins.', select the correct biomedical concept corresponding to 'interleukin-8'. Answer using one of the provided options. | <Options>: A: il1f8 (homo sapiens) (aka interleukin 36 beta)
B: il8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
C: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
D: il18 (homo sapiens) (aka interleukin 18)
E: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
F: None of the above. | B |
<Instruct>: Given the context 'Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia.', select the correct biomedical concept corresponding to 'c5a receptor'. Answer using one of the provided options. | <Options>: A: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
B: c5r1 (homo sapiens) (aka complement c5a receptor 1)
C: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
D: c5ar (mus musculus) (aka complement component 5a receptor 1)
E: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
F: None of the above. | B |
<Instruct>: Given the context 'These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains.', select the correct biomedical concept corresponding to 'c5a-receptor'. Answer using one of the provided options. | <Options>: A: c5r1 (homo sapiens) (aka complement c5a receptor 1)
B: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
C: c5ar (mus musculus) (aka complement component 5a receptor 1)
D: c5ar1 (bos taurus) (aka complement c5a receptor 1)
E: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
F: None of the above. | A |
<Instruct>: Given the context 'We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.', select the correct biomedical concept corresponding to 'c5a receptor'. Answer using one of the provided options. | <Options>: A: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
B: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
C: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
D: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
E: c5ar (mus musculus) (aka complement component 5a receptor 1)
F: None of the above. | D |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk1 (homo sapiens) (aka ephrin a1)
B: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk7 (homo sapiens) (aka ephrin a5)
E: lerk-4 (homo sapiens) (aka ephrin a4)
F: None of the above. | C |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept corresponding to 'eph-related receptor human embryonal kinase 2'. Answer using one of the provided options. | <Options>: A: epht2 (homo sapiens) (aka eph receptor b1)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: eph receptor a2 (homo sapiens) (aka eph receptor a2)
D: ek2 (homo sapiens) (aka eph receptor b3)
E: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
F: None of the above. | D |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept corresponding to 'embryonal kinase 2'. Answer using one of the provided options. | <Options>: A: etk-2 (mus musculus) (aka tyro3 protein tyrosine kinase 3)
B: ek2 (homo sapiens) (aka eph receptor b3)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: erb-b2 receptor tyrosine kinase 2 (gallus gallus) (aka erb-b2 receptor tyrosine kinase 2)
E: ethanolamine kinase 2 (gallus gallus) (aka ethanolamine kinase 2)
F: None of the above. | B |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: ephb2 (homo sapiens) (aka eph receptor b2)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: ek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
<Instruct>: Given the context 'Transcripts for HEK2 have a wide tissue distribution.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: hek3 (homo sapiens) (aka eph receptor a8)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | B |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6)
B: eph receptor b2 (homo sapiens) (aka eph receptor b2)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: hek2 (homo sapiens) (aka eph receptor b3)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: None of the above. | D |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: ephb2 (homo sapiens) (aka eph receptor b2)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
F: None of the above. | F |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: hek3 (homo sapiens) (aka eph receptor a8)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
F: None of the above. | B |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'interleukin-3'. Answer using one of the provided options. | <Options>: A: il3 (homo sapiens) (aka interleukin 3)
B: il5 (homo sapiens) (aka interleukin 5)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: il-2 (homo sapiens) (aka interleukin 2)
E: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
F: None of the above. | A |
<Instruct>: Given the context 'Within the group of LERKs, LERK-2 and -5 were shown to bind to HEK2.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ek2 (homo sapiens) (aka eph receptor b3)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: hek3 (homo sapiens) (aka eph receptor a8)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | A |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk7 (homo sapiens) (aka ephrin a5)
B: lerk1 (homo sapiens) (aka ephrin a1)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: lerk5 (homo sapiens) (aka ephrin b2)
E: lerk2 (homo sapiens) (aka ephrin b1)
F: None of the above. | E |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ephb2 (homo sapiens) (aka eph receptor b2)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: hek (homo sapiens) (aka eph receptor a3)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: None of the above. | B |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: ek2 (homo sapiens) (aka eph receptor b3)
C: hek (homo sapiens) (aka eph receptor a3)
D: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: None of the above. | B |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk1 (homo sapiens) (aka ephrin a1)
B: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk4 (homo sapiens) (aka ephrin a4)
E: lerk5 (homo sapiens) (aka ephrin b2)
F: None of the above. | C |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: ephb2 (homo sapiens) (aka eph receptor b2)
C: hek2 (homo sapiens) (aka eph receptor b3)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | C |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk-6 (homo sapiens) (aka ephrin a2)
B: lerk5 (homo sapiens) (aka ephrin b2)
C: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
D: lerk7 (homo sapiens) (aka ephrin a5)
E: lerk2 (homo sapiens) (aka ephrin b1)
F: None of the above. | E |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ek2 (homo sapiens) (aka eph receptor b3)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: eph receptor b2 (homo sapiens) (aka eph receptor b2)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | A |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | F |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: lerk-6 (homo sapiens) (aka ephrin a2)
C: lerk5 (homo sapiens) (aka ephrin b2)
D: lerk2 (homo sapiens) (aka ephrin b1)
E: lerk-4 (homo sapiens) (aka ephrin a4)
F: None of the above. | D |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek2 (homo sapiens) (aka eph receptor b3)
B: eph receptor b2 (homo sapiens) (aka eph receptor b2)
C: ehk-2 (homo sapiens) (aka eph receptor a6)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: hek (homo sapiens) (aka eph receptor a3)
F: None of the above. | A |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
B: mitogen-activated protein kinase kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: myk1 (mus musculus) (aka eph receptor b4)
D: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: None of the above. | E |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept corresponding to 'htk'. Answer using one of the provided options. | <Options>: A: atk (homo sapiens) (aka bruton tyrosine kinase)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
D: htk (homo sapiens) (aka eph receptor b4)
E: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
F: None of the above. | D |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: myk1 (mus musculus) (aka eph receptor b4)
C: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
D: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: None of the above. | E |
<Instruct>: Given the context 'In this communication we have investigated the cellular origin of myk-1 expression by in situ hybridisation and RNase protection.', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
B: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
C: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
D: myk1 (homo sapiens) (aka eph receptor b4)
E: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
F: None of the above. | D |
<Instruct>: Given the context 'Murine antisense myk-1 probe specifically recognised ductal and alveolar epithelium in the resting mouse mammary gland.', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
B: myk1 (homo sapiens) (aka eph receptor b4)
C: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
D: mitogen-activated protein kinase kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 1)
E: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
F: None of the above. | B |
<Instruct>: Given the context 'In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells.', select the correct biomedical concept corresponding to 'htk'. Answer using one of the provided options. | <Options>: A: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
B: htkl (homo sapiens) (aka ephrin b2)
C: ttk (homo sapiens) (aka ttk protein kinase)
D: htk (homo sapiens) (aka eph receptor b4)
E: atk (homo sapiens) (aka bruton tyrosine kinase)
F: None of the above. | D |
<Instruct>: Given the context 'Elevated expression of htk was found in several human breast carcinoma cell lines as well as in primary, high grade, infiltrating, ductal carcinomas of the breast.', select the correct biomedical concept corresponding to 'htk'. Answer using one of the provided options. | <Options>: A: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: htkl (homo sapiens) (aka ephrin b2)
D: atk (homo sapiens) (aka bruton tyrosine kinase)
E: htk (homo sapiens) (aka eph receptor b4)
F: None of the above. | E |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
B: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
C: mitogen-activated protein kinase kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 1)
D: myk1 (mus musculus) (aka eph receptor b4)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: None of the above. | E |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept corresponding to 'myk-1'. Answer using one of the provided options. | <Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
C: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
D: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
E: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
F: None of the above. | F |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept corresponding to 'htk'. Answer using one of the provided options. | <Options>: A: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: htk-l (homo sapiens) (aka ephrin b2)
D: atk (homo sapiens) (aka bruton tyrosine kinase)
E: htk (homo sapiens) (aka eph receptor b4)
F: None of the above. | E |
<Instruct>: Given the context 'Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
', select the correct biomedical concept corresponding to 'cltcl'. Answer using one of the provided options. | <Options>: A: cltcl1 (homo sapiens) (aka clathrin heavy chain like 1)
B: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
C: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
D: chloride channel clic-like 1 (xenopus tropicalis) (aka chloride channel clic-like 1)
E: chloride channel clic like 1 (sus scrofa) (aka chloride channel clic like 1)
F: None of the above. | A |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept corresponding to 'cltcl'. Answer using one of the provided options. | <Options>: A: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
B: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
C: cltcl1 (homo sapiens) (aka clathrin heavy chain like 1)
D: chloride channel clic-like 1 (xenopus tropicalis) (aka chloride channel clic-like 1)
E: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
F: None of the above. | C |
<Instruct>: Given the context 'The location of CLTCL on human chromosome 22 near the region commonly deleted in DiGeorge and other apparent haploinsufficiency syndromes warrants further investigation into its relationship with these developmental disorders.', select the correct biomedical concept corresponding to 'cltcl'. Answer using one of the provided options. | <Options>: A: cltc.l (xenopus laevis) (aka clathrin, heavy chain (hc) l homeolog)
B: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
C: chloride channel clic like 1 (sus scrofa) (aka chloride channel clic like 1)
D: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
E: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
F: None of the above. | D |
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