instruction
stringlengths
169
712
input
stringlengths
140
808
response
stringclasses
6 values
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept corresponding to 'rnapi-1a'. Answer using one of the provided options.
<Options>: A: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g) B: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i) C: rpi1 (saccharomyces cerevisiae s288c) (aka rpi1p) D: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a) E: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a) F: None of the above.
F
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept corresponding to 'rnapi-1b'. Answer using one of the provided options.
<Options>: A: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h) B: polr2i (homo sapiens) (aka rna polymerase ii subunit i) C: polr1b (homo sapiens) (aka rna polymerase i subunit b) D: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b) E: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta) F: None of the above.
F
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept corresponding to 'napi-1'. Answer using one of the provided options.
<Options>: A: nipp-1 (homo sapiens) (aka protein phosphatase 1 regulatory subunit 8) B: nasi-1 (homo sapiens) (aka solute carrier family 13 member 1) C: napi-1 (mus musculus) (aka solute carrier family 17 (sodium phosphate), member 1) D: napi-1 (homo sapiens) (aka solute carrier family 17 member 1) E: napi-1 (rattus norvegicus) (aka solute carrier family 17 member 1) F: None of the above.
F
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept corresponding to 'na+/pi cotransporter'. Answer using one of the provided options.
<Options>: A: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2) B: npat (rattus norvegicus) (aka nuclear protein, co-activator of histone transcription) C: solute carrier family 11 member 1 (xenopus tropicalis) (aka solute carrier family 11 member 1) D: npt1 (homo sapiens) (aka solute carrier family 17 member 1) E: solute carrier family 1 member 2 (xenopus tropicalis) (aka solute carrier family 1 member 2) F: None of the above.
D
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept corresponding to 'rnapi-1a'. Answer using one of the provided options.
<Options>: A: rpb11a (homo sapiens) (aka rna polymerase ii subunit j) B: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e) C: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a) D: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i) E: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b) F: None of the above.
F
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept corresponding to 'rnapi-1b'. Answer using one of the provided options.
<Options>: A: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2) B: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h) C: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta) D: polr1b (homo sapiens) (aka rna polymerase i subunit b) E: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l) F: None of the above.
F
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept corresponding to 'rnapi-1b'. Answer using one of the provided options.
<Options>: A: polr2i (homo sapiens) (aka rna polymerase ii subunit i) B: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l) C: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b) D: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta) E: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b) F: None of the above.
F
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept corresponding to 'rnapi-1a'. Answer using one of the provided options.
<Options>: A: rpb11a (homo sapiens) (aka rna polymerase ii subunit j) B: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e) C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h) D: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a) E: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b) F: None of the above.
F
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept corresponding to 'rnapi-1b'. Answer using one of the provided options.
<Options>: A: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l) B: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b) C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h) D: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta) E: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i) F: None of the above.
F
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept corresponding to 'rnapi-1a'. Answer using one of the provided options.
<Options>: A: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g) B: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a) C: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i) D: rpb11a (homo sapiens) (aka rna polymerase ii subunit j) E: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b) F: None of the above.
F
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept corresponding to 'rnapi-1b'. Answer using one of the provided options.
<Options>: A: polr2i (homo sapiens) (aka rna polymerase ii subunit i) B: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b) C: polr1b (homo sapiens) (aka rna polymerase i subunit b) D: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l) E: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h) F: None of the above.
F
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept corresponding to 'p50csk'. Answer using one of the provided options.
<Options>: A: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2) B: rps6kc1 (homo sapiens) (aka ribosomal protein s6 kinase c1) C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) D: sck (homo sapiens) (aka shc adaptor protein 2) E: csk (homo sapiens) (aka c-terminal src kinase) F: None of the above.
E
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) B: pepa (homo sapiens) (aka carnosine dipeptidase 2) C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) D: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor) E: pepe (homo sapiens) (aka peptidase e) F: None of the above.
C
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept corresponding to 'p50csk'. Answer using one of the provided options.
<Options>: A: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1) B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) C: rps6kc1 (homo sapiens) (aka ribosomal protein s6 kinase c1) D: prkcsh (homo sapiens) (aka prkcsh beta subunit of glucosidase ii) E: csk (homo sapiens) (aka c-terminal src kinase) F: None of the above.
E
<Instruct>: Given the context 'We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) B: csk (homo sapiens) (aka c-terminal src kinase) C: csk (mus musculus) (aka c-src tyrosine kinase) D: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) E: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog) F: None of the above.
B
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog) C: csk (homo sapiens) (aka c-terminal src kinase) D: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog) E: sck (homo sapiens) (aka shc adaptor protein 2) F: None of the above.
C
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: sck (homo sapiens) (aka shc adaptor protein 2) B: csk (homo sapiens) (aka c-terminal src kinase) C: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase) D: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) E: csk (mus musculus) (aka c-src tyrosine kinase) F: None of the above.
B
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) C: sck (homo sapiens) (aka shc adaptor protein 2) D: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog) E: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) F: None of the above.
F
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) B: sck (homo sapiens) (aka shc adaptor protein 2) C: csk (homo sapiens) (aka c-terminal src kinase) D: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) E: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog) F: None of the above.
C
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes) B: pepe (homo sapiens) (aka peptidase e) C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) D: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) E: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor) F: None of the above.
C
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: sck (homo sapiens) (aka shc adaptor protein 2) B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) C: csk (homo sapiens) (aka c-terminal src kinase) D: csk (mus musculus) (aka c-src tyrosine kinase) E: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) F: None of the above.
C
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) B: peps (homo sapiens) (aka leucine aminopeptidase 3) C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) D: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes) E: pepa (homo sapiens) (aka carnosine dipeptidase 2) F: None of the above.
A
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) B: csk (homo sapiens) (aka c-terminal src kinase) C: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog) D: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) E: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) F: None of the above.
B
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5) B: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3) C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) D: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes) E: pepe (homo sapiens) (aka peptidase e) F: None of the above.
C
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase) B: csk (homo sapiens) (aka c-terminal src kinase) C: csk (mus musculus) (aka c-src tyrosine kinase) D: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) E: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) F: None of the above.
B
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5) B: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3) C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) D: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) E: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes) F: None of the above.
C
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5) B: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) D: pepe (homo sapiens) (aka peptidase e) E: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor) F: None of the above.
B
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept corresponding to 'p50csk'. Answer using one of the provided options.
<Options>: A: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2) B: csk (homo sapiens) (aka c-terminal src kinase) C: rps6kc1 (homo sapiens) (aka ribosomal protein s6 kinase c1) D: p50csk (mus musculus) (aka c-src tyrosine kinase) E: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) F: None of the above.
B
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept corresponding to 'p50csk'. Answer using one of the provided options.
<Options>: A: rps6kc1 (homo sapiens) (aka ribosomal protein s6 kinase c1) B: prkcsl (homo sapiens) (aka myristoylated alanine rich protein kinase c substrate) C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) D: p50csk (mus musculus) (aka c-src tyrosine kinase) E: sck (homo sapiens) (aka shc adaptor protein 2) F: None of the above.
F
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept corresponding to 'pep'. Answer using one of the provided options.
<Options>: A: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a) B: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22) C: pepa (homo sapiens) (aka carnosine dipeptidase 2) D: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3) E: pepe (homo sapiens) (aka peptidase e) F: None of the above.
B
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept corresponding to 'csk'. Answer using one of the provided options.
<Options>: A: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog) B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase) C: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink) D: csk (homo sapiens) (aka c-terminal src kinase) E: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1) F: None of the above.
D
<Instruct>: Given the context 'cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries. ', select the correct biomedical concept corresponding to 'allograft inflammatory factor-1'. Answer using one of the provided options.
<Options>: A: il1f1 (homo sapiens) (aka interleukin 1 alpha) B: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like) C: ilf1 (homo sapiens) (aka forkhead box k2) D: interferon regulatory factor 1 (homo sapiens) (aka interferon regulatory factor 1) E: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1) F: None of the above.
E
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept corresponding to 'allograft inflammatory factor-1'. Answer using one of the provided options.
<Options>: A: ilf-1 (homo sapiens) (aka forkhead box k2) B: interferon regulatory factor 1 (homo sapiens) (aka interferon regulatory factor 1) C: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1) D: il1f1 (homo sapiens) (aka interleukin 1 alpha) E: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1) F: None of the above.
E
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept corresponding to 'aif-1'. Answer using one of the provided options.
<Options>: A: aif-1 (homo sapiens) (aka allograft inflammatory factor 1) B: aif1l (homo sapiens) (aka allograft inflammatory factor 1 like) C: aifl (homo sapiens) (aka aif family member 3) D: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1) E: aif family member 2 (homo sapiens) (aka aif family member 2) F: None of the above.
A
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept corresponding to 'ifn gamma'. Answer using one of the provided options.
<Options>: A: interferon gamma (gallus gallus) (aka interferon gamma) B: gmf-gamma (homo sapiens) (aka glia maturation factor gamma) C: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma) D: interferon gamma (sus scrofa) (aka interferon gamma) E: interferon gamma (xenopus tropicalis) (aka interferon gamma) F: None of the above.
F
<Instruct>: Given the context 'This human AIF-1 homologue is inducible in serum and cytokine-stimulated human smooth muscle cells.', select the correct biomedical concept corresponding to 'aif-1'. Answer using one of the provided options.
<Options>: A: aif family member 2 (homo sapiens) (aka aif family member 2) B: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1) C: aif1l (homo sapiens) (aka allograft inflammatory factor 1 like) D: aifm1 (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1) E: aif-1 (homo sapiens) (aka allograft inflammatory factor 1) F: None of the above.
E
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. ', select the correct biomedical concept corresponding to 'neurokinin-3 receptor'. Answer using one of the provided options.
<Options>: A: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) B: tachykinin receptor 3 (sus scrofa) (aka tachykinin receptor 3) C: nk2r (homo sapiens) (aka tachykinin receptor 2) D: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3) E: nk-3r (homo sapiens) (aka tachykinin receptor 3) F: None of the above.
E
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. ', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: neuromedin b (bos taurus) (aka neuromedin b) B: neuromedin b (rattus norvegicus) (aka neuromedin b) C: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1) D: nknb (homo sapiens) (aka tachykinin precursor 3) E: nkb (sus scrofa) (aka tachykinin precursor 3) F: None of the above.
D
<Instruct>: Given the context 'In 1992, Xie et al. identified a cDNA sequence in the expression cloning search for the kappa opioid receptor.', select the correct biomedical concept corresponding to 'kappa opioid receptor'. Answer using one of the provided options.
<Options>: A: opioid growth factor receptor (rattus norvegicus) (aka opioid growth factor receptor) B: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1) C: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1) D: oprk (homo sapiens) (aka opioid receptor kappa 1) E: opioid receptor, kappa 1 (mus musculus) (aka opioid receptor, kappa 1) F: None of the above.
D
<Instruct>: Given the context 'In 1992, Xie et al. identified a cDNA sequence in the expression cloning search for the kappa opioid receptor.', select the correct biomedical concept corresponding to 'kappa opioid receptor'. Answer using one of the provided options.
<Options>: A: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1) B: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1) C: opioid receptor, kappa 1 (rattus norvegicus) (aka opioid receptor, kappa 1) D: opioid receptor, kappa 1 (mus musculus) (aka opioid receptor, kappa 1) E: opioid growth factor receptor (rattus norvegicus) (aka opioid growth factor receptor) F: None of the above.
F
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept corresponding to 'neurokinin-3 (nk-3) receptor'. Answer using one of the provided options.
<Options>: A: nk3r (homo sapiens) (aka tachykinin receptor 3) B: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3) C: nk2r (homo sapiens) (aka tachykinin receptor 2) D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) E: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) F: None of the above.
A
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept corresponding to 'nk-1'. Answer using one of the provided options.
<Options>: A: nkr (rattus norvegicus) (aka tachykinin receptor 3) B: nkr-p1 (homo sapiens) (aka killer cell lectin like receptor b1) C: nk1r (homo sapiens) (aka tachykinin receptor 1) D: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) E: nk3r (homo sapiens) (aka tachykinin receptor 3) F: None of the above.
C
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept corresponding to 'nk-2'. Answer using one of the provided options.
<Options>: A: nk3r (homo sapiens) (aka tachykinin receptor 3) B: nk2.3 (homo sapiens) (aka nk2 homeobox 3) C: nk2 (homo sapiens) (aka tachykinin precursor 1) D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2) E: nk-2 (homo sapiens) (aka nk2 homeobox 1) F: None of the above.
D
<Instruct>: Given the context 'This sequence was stably expressed in Chinese hamster ovary cells, which do not express neurokinin receptors naturally, and ligand binding and second messenger characteristics were compared with a human NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) B: nk3r (mus musculus) (aka tachykinin receptor 3) C: nk2r (homo sapiens) (aka tachykinin receptor 2) D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) E: tac3r (homo sapiens) (aka tachykinin receptor 3) F: None of the above.
E
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2) B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) D: nk3r (mus musculus) (aka tachykinin receptor 3) E: nk3r (homo sapiens) (aka tachykinin receptor 3) F: None of the above.
E
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: nk3r (homo sapiens) (aka tachykinin receptor 3) B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) D: nk2r (homo sapiens) (aka tachykinin receptor 2) E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) F: None of the above.
A
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: nk3r (mus musculus) (aka tachykinin receptor 3) B: tac3r (homo sapiens) (aka tachykinin receptor 3) C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) E: nk2r (homo sapiens) (aka tachykinin receptor 2) F: None of the above.
B
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: neuropeptide b (rattus norvegicus) (aka neuropeptide b) B: neuropeptide b (homo sapiens) (aka neuropeptide b) C: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2) D: nknb (homo sapiens) (aka tachykinin precursor 3) E: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1) F: None of the above.
D
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'substance p'. Answer using one of the provided options.
<Options>: A: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1) B: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1) C: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4) D: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3) E: tachykinin precursor 3 (rattus norvegicus) (aka tachykinin precursor 3) F: None of the above.
A
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'neurokinin a'. Answer using one of the provided options.
<Options>: A: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1) B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1) D: nkb (homo sapiens) (aka tachykinin precursor 3) E: nkna (homo sapiens) (aka tachykinin precursor 1) F: None of the above.
E
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'neurokinin a'. Answer using one of the provided options.
<Options>: A: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1) B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) C: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1) D: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1) E: nkb (homo sapiens) (aka tachykinin precursor 3) F: None of the above.
F
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: nknb (homo sapiens) (aka tachykinin precursor 3) B: neuromedin b (bos taurus) (aka neuromedin b) C: nkb (sus scrofa) (aka tachykinin precursor 3) D: neuromedin b (homo sapiens) (aka neuromedin b) E: neuropeptide b (homo sapiens) (aka neuropeptide b) F: None of the above.
A
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: neuropeptide b (homo sapiens) (aka neuropeptide b) B: neuromedin b (homo sapiens) (aka neuromedin b) C: nknb (homo sapiens) (aka tachykinin precursor 3) D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2) E: nkb (sus scrofa) (aka tachykinin precursor 3) F: None of the above.
C
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: nknb (homo sapiens) (aka tachykinin precursor 3) B: neuropeptide b (rattus norvegicus) (aka neuropeptide b) C: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1) D: neuromedin b (rattus norvegicus) (aka neuromedin b) E: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2) F: None of the above.
A
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: tachykinin receptor 3 (homo sapiens) (aka tachykinin receptor 3) B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) C: nk3r (mus musculus) (aka tachykinin receptor 3) D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) F: None of the above.
A
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: neuropeptide b (rattus norvegicus) (aka neuropeptide b) B: neuromedin b (rattus norvegicus) (aka neuromedin b) C: nknb (homo sapiens) (aka tachykinin precursor 3) D: neuropeptide b (homo sapiens) (aka neuropeptide b) E: neuromedin b (bos taurus) (aka neuromedin b) F: None of the above.
C
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical concept corresponding to 'neurokinin b'. Answer using one of the provided options.
<Options>: A: nknb (homo sapiens) (aka tachykinin precursor 3) B: neuromedin b (rattus norvegicus) (aka neuromedin b) C: neuromedin b (bos taurus) (aka neuromedin b) D: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1) E: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2) F: None of the above.
A
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical concept corresponding to 'nka'. Answer using one of the provided options.
<Options>: A: nkna (homo sapiens) (aka tachykinin precursor 1) B: nkna (xenopus tropicalis) (aka tachykinin precursor 1) C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1) D: nknb (homo sapiens) (aka tachykinin precursor 3) E: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) F: None of the above.
A
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical concept corresponding to 'substance p'. Answer using one of the provided options.
<Options>: A: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1) B: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1) C: neuropeptide s (rattus norvegicus) (aka neuropeptide s) D: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3) E: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1) F: None of the above.
A
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) C: nk2r (homo sapiens) (aka tachykinin receptor 2) D: nk-3r (homo sapiens) (aka tachykinin receptor 3) E: nk3r (mus musculus) (aka tachykinin receptor 3) F: None of the above.
D
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) C: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3) D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) E: nk3r (mus musculus) (aka tachykinin receptor 3) F: None of the above.
C
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept corresponding to 'nk-3 receptor'. Answer using one of the provided options.
<Options>: A: nk3r (mus musculus) (aka tachykinin receptor 3) B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3) C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2) D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3) E: nk2r (homo sapiens) (aka tachykinin receptor 2) F: None of the above.
F
<Instruct>: Given the context 'Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. ', select the correct biomedical concept corresponding to 'c-type natriuretic peptide'. Answer using one of the provided options.
<Options>: A: natriuretic peptide c (xenopus tropicalis) (aka natriuretic peptide c) B: natriuretic peptide c (homo sapiens) (aka natriuretic peptide c) C: natriuretic peptide c (gallus gallus) (aka natriuretic peptide c) D: c-type natriuretic peptide 1 (xenopus tropicalis) (aka c-type natriuretic peptide 1) E: natriuretic peptide a (homo sapiens) (aka natriuretic peptide a) F: None of the above.
B
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept corresponding to 'c-type natriuretic peptide'. Answer using one of the provided options.
<Options>: A: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c) B: natriuretic peptide c (sus scrofa) (aka natriuretic peptide c) C: natriuretic peptide c (xenopus tropicalis) (aka natriuretic peptide c) D: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) E: natriuretic peptide c (rattus norvegicus) (aka natriuretic peptide c) F: None of the above.
A
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp2 (homo sapiens) (aka natriuretic peptide c) B: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c) C: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase) D: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) E: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l homeolog) F: None of the above.
A
<Instruct>: Given the context 'Several positive clones with specific binding abilities were obtained, and one was identical as TSC-22, a speculated transcriptional modulator stimulated by transforming growth factor beta (TGF-beta) of unknown function.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc-22 (xenopus tropicalis) (aka tsc22 domain family member 1) B: tsc-22 (mus musculus) (aka tsc22 domain family, member 1) C: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4) D: tsc-22r (homo sapiens) (aka tsc22 domain family member 3) E: tsc22 (homo sapiens) (aka tsc22 domain family member 1) F: None of the above.
E
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc-22 (drosophila melanogaster) (aka bunched) B: tsc24 (homo sapiens) (aka testis expressed 35) C: tsc22 (homo sapiens) (aka tsc22 domain family member 1) D: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4) E: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2) F: None of the above.
C
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase) B: cnp (xenopus tropicalis) (2',3'-cyclic nucleotide 3' phosphodiesterase (xenopus tropicalis)) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase) C: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c) D: cnp2 (homo sapiens) (aka natriuretic peptide c) E: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3) F: None of the above.
D
<Instruct>: Given the context 'We further cloned a 1.8-kb full-length human TSC-22 cDNA from a fetal kidney cDNA library by a combination of polymerase chain reaction and the rapid amplification of the cDNA ends technique.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc22 (homo sapiens) (aka tsc22 domain family member 1) B: tsc22 domain family member 2 (homo sapiens) (aka tsc22 domain family member 2) C: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2) D: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1) E: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4) F: None of the above.
A
<Instruct>: Given the context 'In adults, human TSC-22 mRNA was highly expressed in brain, lung and heart.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc22 domain family member 2 (homo sapiens) (aka tsc22 domain family member 2) B: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1) C: tsc22 (homo sapiens) (aka tsc22 domain family member 1) D: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2) E: tsc-22r (homo sapiens) (aka tsc22 domain family member 3) F: None of the above.
C
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1) B: tsc-22 (mus musculus) (aka tsc22 domain family, member 1) C: tsc-22 (drosophila melanogaster) (aka bunched) D: tsc22 (homo sapiens) (aka tsc22 domain family member 1) E: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4) F: None of the above.
D
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3) B: cnp (oryctolagus cuniculus) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase) C: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) D: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c) E: cnp2 (homo sapiens) (aka natriuretic peptide c) F: None of the above.
E
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp (oryctolagus cuniculus) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase) B: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3) C: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l homeolog) D: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) E: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase) F: None of the above.
F
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept corresponding to 'tsc-22'. Answer using one of the provided options.
<Options>: A: tsc22 (homo sapiens) (aka tsc22 domain family member 1) B: tsc-22r (homo sapiens) (aka tsc22 domain family member 3) C: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1) D: tsc-22 (mus musculus) (aka tsc22 domain family, member 1) E: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4) F: None of the above.
A
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase) B: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) C: cnp (oryctolagus cuniculus) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase) D: cnp (xenopus laevis) (natriuretic peptide c s homeolog (xenopus laevis)) (aka natriuretic peptide c s homeolog) E: cnp2 (homo sapiens) (aka natriuretic peptide c) F: None of the above.
E
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept corresponding to 'cnp'. Answer using one of the provided options.
<Options>: A: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase) B: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c) C: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like) D: cnp2 (homo sapiens) (aka natriuretic peptide c) E: cnp (xenopus laevis) (natriuretic peptide c s homeolog (xenopus laevis)) (aka natriuretic peptide c s homeolog) F: None of the above.
D
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12. ', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) B: rep8 (xenopus tropicalis) (aka ubx domain protein 8) C: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1) D: rep8 (homo sapiens) (aka ubx domain protein 8) E: rep-1 (homo sapiens) (aka chm rab escort protein) F: None of the above.
D
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12. ', select the correct biomedical concept corresponding to 'd8s2298e'. Answer using one of the provided options.
<Options>: A: d6s229e (homo sapiens) (aka zinc finger protein 76) B: d0h8s2298e (mus musculus) (aka ubx domain protein 8) C: d6s228e (homo sapiens) (aka collagen type xix alpha 1 chain) D: d8s2298e (homo sapiens) (aka ubx domain protein 8) E: s8e (drosophila melanogaster) (aka ribosomal protein s8) F: None of the above.
D
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: rep8 (xenopus tropicalis) (aka ubx domain protein 8) B: rep15 (homo sapiens) (aka rab15 effector protein) C: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) D: rep8 (homo sapiens) (aka ubx domain protein 8) E: rep-1 (homo sapiens) (aka chm rab escort protein) F: None of the above.
D
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept corresponding to 'd8s2298e'. Answer using one of the provided options.
<Options>: A: s8e (drosophila melanogaster) (aka ribosomal protein s8) B: d6s228e (homo sapiens) (aka collagen type xix alpha 1 chain) C: d8s2298e (homo sapiens) (aka ubx domain protein 8) D: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase) E: d6s229e (homo sapiens) (aka zinc finger protein 76) F: None of the above.
C
<Instruct>: Given the context 'The gene consists of eight exons and spans about 20 kb between the glutathione S-reductase and the protein phosphatase 2A beta subunit genes.', select the correct biomedical concept corresponding to 'glutathione s-reductase'. Answer using one of the provided options.
<Options>: A: glutathione synthetase (sus scrofa) (aka glutathione synthetase) B: gsr (sus scrofa) (aka glutathione-disulfide reductase) C: glutathione-disulfide reductase (homo sapiens) (aka glutathione-disulfide reductase) D: glutathione-disulfide reductase glr1 (saccharomyces cerevisiae s288c) (aka glutathione-disulfide reductase glr1) E: glutathione reductase (glycine max) (aka glutathione reductase) F: None of the above.
C
<Instruct>: Given the context 'The full-length Rep-8 gene contains 1483 nucleotides and codes for a protein of 270 amino acids.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: rep8 (homo sapiens) (aka ubx domain protein 8) B: rep-1 (homo sapiens) (aka chm rab escort protein) C: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) D: rep8 (xenopus tropicalis) (aka ubx domain protein 8) E: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep) F: None of the above.
A
<Instruct>: Given the context 'Southern blot experiments showed that the Rep-8 gene exists as a single copy per haploid.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: rep8 (homo sapiens) (aka ubx domain protein 8) B: rep8 (xenopus tropicalis) (aka ubx domain protein 8) C: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep) D: rep15 (homo sapiens) (aka rab15 effector protein) E: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4) F: None of the above.
A
<Instruct>: Given the context 'Southern blot experiments showed that the Rep-8 gene exists as a single copy per haploid.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1) B: rep15 (homo sapiens) (aka rab15 effector protein) C: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep) D: rep-1 (homo sapiens) (aka chm rab escort protein) E: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) F: None of the above.
F
<Instruct>: Given the context 'With a zoo blot analysis, human Rep-8 DNA hybridized strongly with the monkey DNA, but only weakly with the DNAs of species other than Homo sapiens.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep) B: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) C: rep-8 (mus musculus) (aka ubx domain protein 8) D: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4) E: rep8 (homo sapiens) (aka ubx domain protein 8) F: None of the above.
E
<Instruct>: Given the context 'Northern blot analysis showed that it is expressed abundantly in the testis and ovary, suggesting that the Rep-8 gene product may play a role in reproduction.', select the correct biomedical concept corresponding to 'rep-8'. Answer using one of the provided options.
<Options>: A: rep8 (homo sapiens) (aka ubx domain protein 8) B: rep8 (xenopus tropicalis) (aka ubx domain protein 8) C: rep-1 (homo sapiens) (aka chm rab escort protein) D: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep) E: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog) F: None of the above.
A
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. ', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) B: kitl (homo sapiens) (aka kit ligand) C: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) D: cd117 (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) E: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) F: None of the above.
D
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. ', select the correct biomedical concept corresponding to 'fms'. Answer using one of the provided options.
<Options>: A: fms (mus musculus) (aka colony stimulating factor 1 receptor) B: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4) C: fms related receptor tyrosine kinase 1 (homo sapiens) (aka fms related receptor tyrosine kinase 1) D: colony stimulating factor 1 receptor (homo sapiens) (aka colony stimulating factor 1 receptor) E: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase) F: None of the above.
D
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) B: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) C: cd117 (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) D: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase) E: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) F: None of the above.
C
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept corresponding to 'fms'. Answer using one of the provided options.
<Options>: A: flt-1 (homo sapiens) (aka fms related receptor tyrosine kinase 1) B: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase) C: csf1r (homo sapiens) (aka colony stimulating factor 1 receptor) D: fms related receptor tyrosine kinase 3 (homo sapiens) (aka fms related receptor tyrosine kinase 3) E: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4) F: None of the above.
C
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit ligand (homo sapiens) (aka kit ligand) B: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) C: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) D: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) E: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase) F: None of the above.
D
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept corresponding to 'fms'. Answer using one of the provided options.
<Options>: A: fms (mus musculus) (aka colony stimulating factor 1 receptor) B: fms related receptor tyrosine kinase 3 (homo sapiens) (aka fms related receptor tyrosine kinase 3) C: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase) D: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4) E: colony stimulating factor 1 receptor (homo sapiens) (aka colony stimulating factor 1 receptor) F: None of the above.
E
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) B: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) C: kitl (homo sapiens) (aka kit ligand) D: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) E: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) F: None of the above.
E
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit ligand (homo sapiens) (aka kit ligand) B: cd117 (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) C: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) D: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) E: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) F: None of the above.
B
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit ligand (homo sapiens) (aka kit ligand) B: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase) C: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) D: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) E: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) F: None of the above.
F
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept corresponding to 'kit'. Answer using one of the provided options.
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase) B: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase) C: kit ligand (homo sapiens) (aka kit ligand) D: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase) E: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase) F: None of the above.
B
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept corresponding to 'fms'. Answer using one of the provided options.
<Options>: A: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4) B: c-fms (homo sapiens) (aka colony stimulating factor 1 receptor) C: fms related receptor tyrosine kinase 1 (homo sapiens) (aka fms related receptor tyrosine kinase 1) D: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase) E: fms (mus musculus) (aka colony stimulating factor 1 receptor) F: None of the above.
B
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept corresponding to 'smf'. Answer using one of the provided options.
<Options>: A: shf (mus musculus) (aka src homology 2 domain containing f) B: myhsf (mus musculus) (aka myosin, heavy polypeptide 4, skeletal muscle) C: small ribonucleoprotein particle protein smf (drosophila melanogaster) (aka small ribonucleoprotein particle protein smf) D: ssf1 (mus musculus) (aka peter pan homolog) E: sm-f (homo sapiens) (aka small nuclear ribonucleoprotein polypeptide f) F: None of the above.
F
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept corresponding to 'fms'. Answer using one of the provided options.
<Options>: A: fms (homo sapiens) (aka colony stimulating factor 1 receptor) B: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4) C: fms related receptor tyrosine kinase 1 (homo sapiens) (aka fms related receptor tyrosine kinase 1) D: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase) E: fms (mus musculus) (aka colony stimulating factor 1 receptor) F: None of the above.
A
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept corresponding to '56 kda selenium binding protein'. Answer using one of the provided options.
<Options>: A: sbp56 (xenopus laevis) (selenium binding protein 1 l homeolog (xenopus laevis)) (aka selenium binding protein 1 l homeolog) B: selenium binding protein 1 (xenopus tropicalis) (aka selenium binding protein 1) C: sp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog) D: selenium binding protein 1 (gallus gallus) (aka selenium binding protein 1) E: sbp56 (homo sapiens) (aka selenium binding protein 1) F: None of the above.
E