instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept corresponding to 'hsp56'. Answer using one of the provided options. | <Options>: A: hca56 (homo sapiens) (aka eukaryotic translation initiation factor 2d)
B: sp56 (homo sapiens) (aka selenium binding protein 1)
C: prss56 (homo sapiens) (aka serine protease 56)
D: pp5656 (homo sapiens) (aka large xylosyl- and glucuronyltransferase 2)
E: ppp1r56 (homo sapiens) (aka caspase 9)
F: None of the above. | B |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept corresponding to '56 kda selenium binding protein'. Answer using one of the provided options. | <Options>: A: selenium binding protein 1 (xenopus tropicalis) (aka selenium binding protein 1)
B: selenium binding protein 1 (homo sapiens) (aka selenium binding protein 1)
C: sbp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog)
D: sbp56 (xenopus laevis) (selenium binding protein 1 l homeolog (xenopus laevis)) (aka selenium binding protein 1 l homeolog)
E: selenium binding protein 1 (bos taurus) (aka selenium binding protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'Using Northern blot hybridization, we found that this 56 kDa selenium binding protein is expressed in mouse heart with an intermediate level between those found in liver/lung/kidney and intestine.', select the correct biomedical concept corresponding to '56 kda selenium binding protein'. Answer using one of the provided options. | <Options>: A: sp56 (xenopus laevis) (selenium binding protein 1 l homeolog (xenopus laevis)) (aka selenium binding protein 1 l homeolog)
B: selenium binding protein 1 (bos taurus) (aka selenium binding protein 1)
C: selenbp1 (homo sapiens) (aka selenium binding protein 1)
D: selenium binding protein 1 (xenopus tropicalis) (aka selenium binding protein 1)
E: sp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'We have also successfully expressed hSP56 in Escherichia coli using the expression vector-pAED4.', select the correct biomedical concept corresponding to 'hsp56'. Answer using one of the provided options. | <Options>: A: hca56 (homo sapiens) (aka eukaryotic translation initiation factor 2d)
B: ppp1r56 (homo sapiens) (aka caspase 9)
C: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
D: prss56 (homo sapiens) (aka serine protease 56)
E: sp56 (homo sapiens) (aka selenium binding protein 1)
F: None of the above. | E |
<Instruct>: Given the context 'The hSP56 gene is located at human chromosome 1q21-22).', select the correct biomedical concept corresponding to 'hsp56'. Answer using one of the provided options. | <Options>: A: ppp1r56 (homo sapiens) (aka caspase 9)
B: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
C: sbp56 (homo sapiens) (aka selenium binding protein 1)
D: hc56 (homo sapiens) (aka gem nuclear organelle associated protein 4)
E: prss56 (homo sapiens) (aka serine protease 56)
F: None of the above. | C |
<Instruct>: Given the context 'The hSP56 gene is located at human chromosome 1q21-22).', select the correct biomedical concept corresponding to 'hsp56'. Answer using one of the provided options. | <Options>: A: spg56 (homo sapiens) (aka cytochrome p450 family 2 subfamily u member 1)
B: prss56 (homo sapiens) (aka serine protease 56)
C: pp5656 (homo sapiens) (aka large xylosyl- and glucuronyltransferase 2)
D: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
E: hc56 (homo sapiens) (aka gem nuclear organelle associated protein 4)
F: None of the above. | F |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
B: l(2)k04218 (drosophila melanogaster) (aka charlatan)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
E: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | D |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept corresponding to 'myotonic dystrophy protein kinase'. Answer using one of the provided options. | <Options>: A: deoxythymidylate kinase (mus musculus) (aka deoxythymidylate kinase)
B: protein kinase d2 (mus musculus) (aka protein kinase d2)
C: dtk (mus musculus) (aka tyro3 protein tyrosine kinase 3)
D: dm1 protein kinase (xenopus tropicalis) (aka dm1 protein kinase)
E: dm1 (homo sapiens) (dm1 protein kinase (homo sapiens)) (aka dm1 protein kinase)
F: None of the above. | E |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept corresponding to 'dm-pk'. Answer using one of the provided options. | <Options>: A: dmkp (drosophila melanogaster) (aka map kinase-specific phosphatase)
B: drm-pk-1 (drosophila melanogaster) (aka capability)
C: pkm (drosophila melanogaster) (pyruvate kinase (drosophila melanogaster)) (aka pyruvate kinase)
D: dmk (drosophila melanogaster) (aka kinesin heavy chain)
E: mdpk (mus musculus) (aka dystrophia myotonica-protein kinase)
F: None of the above. | F |
<Instruct>: Given the context 'Northern blots demonstrate that PK428 mRNA is distributed widely among tissues and is expressed at the highest levels in pancreas, heart, and skeletal muscle, with lower levels in liver and lung.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
B: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
E: l(2)k05428 (drosophila melanogaster) (aka dribble)
F: None of the above. | B |
<Instruct>: Given the context 'Two PK428 mRNAs 10 and 3.8 kilobase pairs in size are seen in a number of cell lines, including hematopoietic and breast cancer cells.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
B: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
E: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | A |
<Instruct>: Given the context 'Immunoprecipitation of the transiently expressed PK428 protein and incubation with [gamma-32P]ATP demonstrate that it is capable of autophosphorylation.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
B: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
C: cg43428 (drosophila melanogaster) (aka uncharacterized protein)
D: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
E: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, immunoprecipitates of the PK428 protein kinase also phosphorylated histone H1 and a peptide encoding a cyclic AMP-dependent protein kinase substrate.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
B: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
C: l(2)k04218 (drosophila melanogaster) (aka charlatan)
D: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein beta subunit)
E: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
F: None of the above. | E |
<Instruct>: Given the context 'The gene corresponding to the 3.8-kb PK428 mRNA, and its corresponding 65-kDa protein, was isolated by polymerase chain reaction screening of a P1 phage human genomic library.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
B: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
C: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
D: l(2)k05428 (drosophila melanogaster) (aka dribble)
E: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | A |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concept corresponding to 'pk428'. Answer using one of the provided options. | <Options>: A: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
B: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein beta subunit)
C: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
D: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
E: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
F: None of the above. | E |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concept corresponding to 'a gene associated with rippling muscle disease'. Answer using one of the provided options. | <Options>: A: adipose differentiation related protein, pseudogene (mus musculus) (aka adipose differentiation related protein, pseudogene)
B: ras-related associated with diabetes (mus musculus) (aka ras-related associated with diabetes)
C: reactive intermediate imine deaminase a homolog (mus musculus) (aka reactive intermediate imine deaminase a homolog)
D: peptidase domain containing associated with muscle regeneration 1 (mus musculus) (aka peptidase domain containing associated with muscle regeneration 1)
E: rmd1 (homo sapiens) (rippling muscle disease 1 (homo sapiens)) (aka rippling muscle disease 1)
F: None of the above. | E |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concept corresponding to 'a gene associated with rippling muscle disease'. Answer using one of the provided options. | <Options>: A: adipose differentiation related protein, pseudogene (mus musculus) (aka adipose differentiation related protein, pseudogene)
B: arv1 homolog, fatty acid homeostasis modulator (gallus gallus) (aka arv1 homolog, fatty acid homeostasis modulator)
C: steroidogenic acute regulatory protein, mitochondrial-like (gallus gallus) (aka steroidogenic acute regulatory protein, mitochondrial-like)
D: reactive intermediate imine deaminase a homolog (gallus gallus) (aka reactive intermediate imine deaminase a homolog)
E: peptidase domain containing associated with muscle regeneration 1 (mus musculus) (aka peptidase domain containing associated with muscle regeneration 1)
F: None of the above. | F |
<Instruct>: Given the context 'Isolation and characterization of a structural homologue of human PRK2 from rat liver.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: pkn2 (homo sapiens) (aka protein kinase n2)
B: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
D: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
E: pkc2 (homo sapiens) (aka protein kinase c zeta)
F: None of the above. | A |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept corresponding to 'protein kinase c (pkc)-related kinase-2'. Answer using one of the provided options. | <Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: protein kinase c-like 2 (xenopus tropicalis) (aka protein kinase c-like 2)
C: calcium/calmodulin dependent protein kinase kinase 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase kinase 2)
D: pkn2 (homo sapiens) (aka protein kinase n2)
E: protein kinase c;protein kinase c-like 2 (caenorhabditis elegans) (aka protein kinase c;protein kinase c-like 2)
F: None of the above. | D |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: pk2 (homo sapiens) (aka prokineticin 2)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: prkcb2 (homo sapiens) (aka protein kinase c beta)
D: pak-2 (homo sapiens) (aka protein kinase n2)
E: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: None of the above. | D |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
B: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
C: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
D: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1) activated kinase 2)
E: prk2 (homo sapiens) (aka protein kinase n2)
F: None of the above. | F |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closely (95% sequence identity) to the 130-kDa human PKC-related kinase, PRK2.', select the correct biomedical concept corresponding to 'pak-1'. Answer using one of the provided options. | <Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: alpha-pak (homo sapiens) (aka p21 (rac1) activated kinase 1)
C: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
D: pak-2 (homo sapiens) (aka protein kinase n2)
E: pak-1 (homo sapiens) (aka protein kinase n1)
F: None of the above. | F |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closely (95% sequence identity) to the 130-kDa human PKC-related kinase, PRK2.', select the correct biomedical concept corresponding to 'protein kinase n'. Answer using one of the provided options. | <Options>: A: ndpkc (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 3)
B: protein kinase n (drosophila melanogaster) (aka protein kinase n)
C: npkc-nu (homo sapiens) (aka protein kinase d3)
D: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
E: pkn (homo sapiens) (aka protein kinase n1)
F: None of the above. | F |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closely (95% sequence identity) to the 130-kDa human PKC-related kinase, PRK2.', select the correct biomedical concept corresponding to 'pkn'. Answer using one of the provided options. | <Options>: A: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: pkn1 (homo sapiens) (aka protein kinase n1)
C: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
D: prkcn (homo sapiens) (aka protein kinase d3)
E: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
F: None of the above. | F |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closely (95% sequence identity) to the 130-kDa human PKC-related kinase, PRK2.', select the correct biomedical concept corresponding to '130-kda human pkc-related kinase'. Answer using one of the provided options. | <Options>: A: stk7 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n2)
B: protein kinase n1 (homo sapiens) (aka protein kinase n1)
C: cnk (homo sapiens) (polo like kinase 3 (homo sapiens)) (aka polo like kinase 3)
D: ndpkc (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 3)
E: p90-rsk3 (homo sapiens) (aka ribosomal protein s6 kinase a2)
F: None of the above. | A |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closely (95% sequence identity) to the 130-kDa human PKC-related kinase, PRK2.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: prkcb2 (homo sapiens) (aka protein kinase c beta)
C: pak-2 (homo sapiens) (aka protein kinase n2)
D: pkc2 (homo sapiens) (aka protein kinase c zeta)
E: pk2 (homo sapiens) (aka prokineticin 2)
F: None of the above. | C |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
E: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
F: None of the above. | F |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
B: pak2 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n2)
C: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
E: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: pkc2 (homo sapiens) (aka protein kinase c zeta)
B: pk2 (homo sapiens) (aka prokineticin 2)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
E: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
F: None of the above. | C |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
B: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1) activated kinase 2)
E: pkn2 (homo sapiens) (aka protein kinase n2)
F: None of the above. | F |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
B: prkcb2 (homo sapiens) (aka protein kinase c beta)
C: pkc2 (homo sapiens) (aka protein kinase c zeta)
D: prk2 (homo sapiens) (aka protein kinase n2)
E: pk2 (homo sapiens) (aka prokineticin 2)
F: None of the above. | D |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedical concept corresponding to 'pak-1'. Answer using one of the provided options. | <Options>: A: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
B: pak-2 (homo sapiens) (aka protein kinase n2)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: pak-1 (homo sapiens) (aka protein kinase n1)
E: pakalpha (homo sapiens) (aka p21 (rac1) activated kinase 1)
F: None of the above. | F |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedical concept corresponding to 'pkn'. Answer using one of the provided options. | <Options>: A: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: pkn (homo sapiens) (aka protein kinase n1)
C: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
D: pkn (mus musculus) (aka protein kinase n1)
E: prkn (bos taurus) (aka parkin rbr e3 ubiquitin protein ligase)
F: None of the above. | F |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: prk2 (homo sapiens) (aka protein kinase n2)
C: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1) activated kinase 2)
D: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
E: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: prkcb2 (homo sapiens) (aka protein kinase c beta)
B: pkc2 (homo sapiens) (aka protein kinase c zeta)
C: pk2 (homo sapiens) (aka prokineticin 2)
D: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
E: prk2 (homo sapiens) (aka protein kinase n2)
F: None of the above. | E |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'pak-2'. Answer using one of the provided options. | <Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pak2 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n2)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: p21 (rac1) activated kinase 2 (homo sapiens) (aka p21 (rac1) activated kinase 2)
E: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
F: None of the above. | F |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'prk2'. Answer using one of the provided options. | <Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
D: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
E: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
F: None of the above. | A |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'pak-1'. Answer using one of the provided options. | <Options>: A: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: p65-pak (homo sapiens) (aka p21 (rac1) activated kinase 1)
C: pak7 (homo sapiens) (aka p21 (rac1) activated kinase 5)
D: pak-1 (homo sapiens) (aka protein kinase n1)
E: pak-2 (homo sapiens) (aka protein kinase n2)
F: None of the above. | F |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'pak-1'. Answer using one of the provided options. | <Options>: A: pak-1 (homo sapiens) (aka protein kinase n1)
B: pak7 (homo sapiens) (aka p21 (rac1) activated kinase 5)
C: pakalpha (homo sapiens) (aka p21 (rac1) activated kinase 1)
D: pak-6 (homo sapiens) (aka bub1b-pak6 readthrough)
E: pak-2 (homo sapiens) (aka protein kinase n2)
F: None of the above. | F |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'pkn'. Answer using one of the provided options. | <Options>: A: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
B: pkn (homo sapiens) (aka protein kinase n1)
C: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
D: prkn (bos taurus) (aka parkin rbr e3 ubiquitin protein ligase)
E: pkn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
F: None of the above. | F |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept corresponding to 'prk1'. Answer using one of the provided options. | <Options>: A: pkn (homo sapiens) (aka protein kinase n1)
B: serine/threonine protein kinase prk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase prk1)
C: prk (homo sapiens) (aka polo like kinase 3)
D: prkaa1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
E: prka1 (homo sapiens) (aka a-kinase anchoring protein 1)
F: None of the above. | A |
<Instruct>: Given the context 'Human dipeptidyl-peptidase I. Gene characterization, localization, and expression.
Dipeptidyl-peptidase I, a lysosomal cysteine proteinase, is important in intracellular degradation of proteins and appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
C: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
D: dpp1 (homo sapiens) (aka cathepsin c)
E: dppii (homo sapiens) (aka dipeptidyl peptidase 7)
F: None of the above. | D |
<Instruct>: Given the context 'Human dipeptidyl-peptidase I. Gene characterization, localization, and expression.
Dipeptidyl-peptidase I, a lysosomal cysteine proteinase, is important in intracellular degradation of proteins and appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
B: dipeptidyl peptidase 7 (homo sapiens) (aka dipeptidyl peptidase 7)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
E: dpp1 (homo sapiens) (aka cathepsin c)
F: None of the above. | E |
<Instruct>: Given the context 'In the present investigation the gene for dipeptidyl-peptidase I was cloned and characterized.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: dpp1 (homo sapiens) (aka cathepsin c)
B: dppii (homo sapiens) (aka dipeptidyl peptidase 7)
C: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
D: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
E: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
F: None of the above. | A |
<Instruct>: Given the context 'Northern analyses demonstrated that the dipeptidyl-peptidase I message is expressed at high levels in lung, kidney, and placenta, at moderate to low levels in many organs, and at barely detectable levels in the brain, suggesting tissue-specific regulation.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
B: dpp1 (homo sapiens) (aka cathepsin c)
C: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
D: dipeptidyl peptidase 7 (homo sapiens) (aka dipeptidyl peptidase 7)
E: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
F: None of the above. | B |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept corresponding to 'interleukin-2'. Answer using one of the provided options. | <Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: il-2 (homo sapiens) (aka interleukin 2)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
F: None of the above. | C |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
C: ii (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
D: dppi (homo sapiens) (aka cathepsin c)
E: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
F: None of the above. | D |
<Instruct>: Given the context 'The results provide initial insights into the molecular basis for the regulation of human dipeptidyl-peptidase I.', select the correct biomedical concept corresponding to 'dipeptidyl-peptidase i'. Answer using one of the provided options. | <Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
E: dppi (homo sapiens) (aka cathepsin c)
F: None of the above. | E |
<Instruct>: Given the context 'Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
', select the correct biomedical concept corresponding to 'osteoprotegerin'. Answer using one of the provided options. | <Options>: A: trailr-1 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: tweakr (homo sapiens) (aka tnf receptor superfamily member 12a)
C: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
D: gitrl (homo sapiens) (aka tnf superfamily member 18)
E: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
F: None of the above. | C |
<Instruct>: Given the context 'Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
', select the correct biomedical concept corresponding to 'osteoprotegerin'. Answer using one of the provided options. | <Options>: A: trailr-1 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: gitrl (homo sapiens) (aka tnf superfamily member 18)
C: tweakr (homo sapiens) (aka tnf receptor superfamily member 12a)
D: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (mus musculus) (aka tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin))
E: gitr (homo sapiens) (aka tnf receptor superfamily member 18)
F: None of the above. | F |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept corresponding to 'osteoprotegerin'. Answer using one of the provided options. | <Options>: A: opgl (homo sapiens) (aka tnf superfamily member 11)
B: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (mus musculus) (aka tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin))
C: gitr (homo sapiens) (aka tnf receptor superfamily member 18)
D: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
E: gitrl (homo sapiens) (aka tnf superfamily member 18)
F: None of the above. | D |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b s homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b s homeolog)
C: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
D: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
E: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
F: None of the above. | A |
<Instruct>: Given the context 'In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
B: opgl (homo sapiens) (aka tnf superfamily member 11)
C: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
D: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
E: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
F: None of the above. | C |
<Instruct>: Given the context 'These same effects are observed upon administration of recombinant OPG into normal mice.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b s homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b s homeolog)
C: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
D: opgl (homo sapiens) (aka tnf superfamily member 11)
E: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
F: None of the above. | A |
<Instruct>: Given the context 'In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
B: rankl (homo sapiens) (aka tnf superfamily member 11)
C: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
D: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
E: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'Furthermore, OPG blocks ovariectomy-associated bone loss in rats.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b l homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b l homeolog)
B: opgl (homo sapiens) (aka tnf superfamily member 11)
C: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b s homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b s homeolog)
D: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
E: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
F: None of the above. | D |
<Instruct>: Given the context 'These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
C: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
D: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
E: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b s homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b s homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.', select the correct biomedical concept corresponding to 'opg'. Answer using one of the provided options. | <Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
C: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
D: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
E: rankl (homo sapiens) (aka tnf superfamily member 11)
F: None of the above. | A |
<Instruct>: Given the context 'Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.
', select the correct biomedical concept corresponding to 'rhohp1'. Answer using one of the provided options. | <Options>: A: rhohp1 (homo sapiens) (aka ras homolog family member d)
B: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
C: rhoh (homo sapiens) (aka ras homolog family member h)
D: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
E: rhpn1 (homo sapiens) (aka rhophilin rho gtpase binding protein 1)
F: None of the above. | A |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept corresponding to 'rhohp1'. Answer using one of the provided options. | <Options>: A: rhoh9 (homo sapiens) (aka ras homolog family member c)
B: rhohp1 (homo sapiens) (aka ras homolog family member d)
C: rhoh (homo sapiens) (aka ras homolog family member h)
D: rhpn1 (homo sapiens) (aka rhophilin rho gtpase binding protein 1)
E: rhox homeobox family member 1 (homo sapiens) (aka rhox homeobox family member 1)
F: None of the above. | B |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept corresponding to 'rhohp1'. Answer using one of the provided options. | <Options>: A: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
B: rhoh (homo sapiens) (aka ras homolog family member h)
C: chp/wrch rho-like protein homolog (caenorhabditis elegans) (aka chp/wrch rho-like protein homolog)
D: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
E: rhoh9 (homo sapiens) (aka ras homolog family member c)
F: None of the above. | F |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept corresponding to 'rho-related protein hp1'. Answer using one of the provided options. | <Options>: A: rhoh (homo sapiens) (aka ras homolog family member h)
B: arhp (homo sapiens) (aka dentin matrix acidic phosphoprotein 1)
C: rhohp1 (homo sapiens) (aka ras homolog family member d)
D: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
E: rhoh6 (homo sapiens) (aka ras homolog family member b)
F: None of the above. | C |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept corresponding to 'i kappa b epsilon'. Answer using one of the provided options. | <Options>: A: ikb-epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
B: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
C: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
D: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
E: nfkb inhibitor epsilon (homo sapiens) (aka nfkb inhibitor epsilon)
F: None of the above. | B |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept corresponding to 'rela'. Answer using one of the provided options. | <Options>: A: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: rela (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nf-kappabeta (homo sapiens) (aka nuclear factor kappa b subunit 1)
E: rela proto-oncogene, nf-kb subunit (xenopus tropicalis) (aka rela proto-oncogene, nf-kb subunit)
F: None of the above. | C |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept corresponding to 'crel'. Answer using one of the provided options. | <Options>: A: light-regulated protein-like (glycine max) (aka light-regulated protein-like)
B: crrl (homo sapiens) (aka dickkopf wnt signaling pathway inhibitor 3)
C: cation transport regulator-like protein 2-like (glycine max) (aka cation transport regulator-like protein 2-like)
D: leucine--trna ligase, cytoplasmic-like (glycine max) (aka leucine--trna ligase, cytoplasmic-like)
E: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
F: None of the above. | F |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer using one of the provided options. | <Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
E: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'We have isolated a human cDNA which encodes a novel I kappa B family member using a yeast two-hybrid screen for proteins able to interact with the p52 subunit of the transcription factor NF-kappa B.', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer using one of the provided options. | <Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
E: nf-kb (homo sapiens) (aka nuclear factor kappa b subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'The protein is found in many cell types and its expression is up-regulated following NF-kappa B activation and during myelopoiesis.', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer using one of the provided options. | <Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
E: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
D: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
F: None of the above. | D |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer using one of the provided options. | <Options>: A: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
E: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
F: None of the above. | D |
<Instruct>: Given the context 'I kappa B-epsilon translation initiates from an internal ATG codon to give rise to a protein of 45 kDa, which exists as multiple phosphorylated isoforms in resting cells.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
C: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
D: nfkb inhibitor epsilon (homo sapiens) (aka nfkb inhibitor epsilon)
E: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
F: None of the above. | E |
<Instruct>: Given the context 'I kappa B-epsilon translation initiates from an internal ATG codon to give rise to a protein of 45 kDa, which exists as multiple phosphorylated isoforms in resting cells.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
B: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
E: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
F: None of the above. | F |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept corresponding to 'rela'. Answer using one of the provided options. | <Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
E: rela proto-oncogene, nf-kb subunit (xenopus tropicalis) (aka rela proto-oncogene, nf-kb subunit)
F: None of the above. | C |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept corresponding to 'crel'. Answer using one of the provided options. | <Options>: A: light-regulated protein-like (glycine max) (aka light-regulated protein-like)
B: crem.l (xenopus laevis) (aka camp responsive element modulator l homeolog)
C: crrl (arabidopsis thaliana) (aka chaperone dnaj-domain superfamily protein)
D: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
E: leucine--trna ligase, cytoplasmic-like (glycine max) (aka leucine--trna ligase, cytoplasmic-like)
F: None of the above. | F |
<Instruct>: Given the context 'Upon activation, I kappa B-epsilon protein is degraded with slow kinetics by a proteasome-dependent mechanism.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
C: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
D: i-kappa-b-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
E: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
F: None of the above. | E |
<Instruct>: Given the context 'Similarly to I kappa B-alpha', select the correct biomedical concept corresponding to 'i kappa b-alpha'. Answer using one of the provided options. | <Options>: A: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
B: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
C: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
E: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
F: None of the above. | D |
<Instruct>: Given the context 'and I kappa B, I kappa B-epsilon contains multiple ankyrin repeats and two conserved serines which are necessary for signal-induced degradation of the molecule.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
B: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
C: i-kappa-b-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
D: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
E: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
F: None of the above. | E |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept corresponding to 'i kappa b- alpha'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: ikba (homo sapiens) (aka nfkb inhibitor alpha)
E: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
F: None of the above. | D |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept corresponding to 'i kappa b-beta'. Answer using one of the provided options. | <Options>: A: i-kappa-b-beta (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, beta)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
D: inhibitor of nuclear factor kappa b kinase subunit beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
E: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
F: None of the above. | C |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: i-kappa-b-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
E: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
F: None of the above. | A |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'i kappa b-epsilon'. Answer using one of the provided options. | <Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: ikb-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
F: None of the above. | D |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'rela'. Answer using one of the provided options. | <Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: rela proto-oncogene, nf-kb subunit (xenopus tropicalis) (aka rela proto-oncogene, nf-kb subunit)
C: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
D: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
E: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
F: None of the above. | A |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'rela'. Answer using one of the provided options. | <Options>: A: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
D: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
E: rela proto-oncogene, nf-kb subunit (xenopus tropicalis) (aka rela proto-oncogene, nf-kb subunit)
F: None of the above. | F |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'crel'. Answer using one of the provided options. | <Options>: A: light-regulated protein-like (glycine max) (aka light-regulated protein-like)
B: creg (homo sapiens) (aka cellular repressor of e1a stimulated genes 1)
C: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
D: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
E: creld1 (oryctolagus cuniculus) (aka creld disulfide isomerase 1)
F: None of the above. | F |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
E: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
F: None of the above. | B |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: hvps41 (homo sapiens) (aka vps41 subunit of hops complex)
B: vps41 (drosophila melanogaster) (aka light)
C: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
D: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
E: vps41 (saccharomyces cerevisiae s288c) (aka vps41p)
F: None of the above. | E |
<Instruct>: Given the context 'Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
D: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
E: vps41 (drosophila melanogaster) (aka light)
F: None of the above. | C |
<Instruct>: Given the context 'Our studies predict that VPS41 encodes a hydrophilic protein of 992 amino acids that contains no obvious signal sequence or hydrophobic domains.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: hvsp41 (homo sapiens) (aka vps41 subunit of hops complex)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: vps41 (drosophila melanogaster) (aka light)
D: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
E: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept corresponding to 'vps41p'. Answer using one of the provided options. | <Options>: A: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vps41 (drosophila melanogaster) (aka light)
D: vps41p (candida albicans sc5314) (aka vps41p)
E: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
F: None of the above. | B |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vps41 (drosophila melanogaster) (aka light)
D: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
E: hvsp41 (homo sapiens) (aka vps41 subunit of hops complex)
F: None of the above. | B |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
D: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
E: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
F: None of the above. | B |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: vps41 subunit of hops complex (homo sapiens) (aka vps41 subunit of hops complex)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
D: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
E: vps41 (drosophila melanogaster) (aka light)
F: None of the above. | C |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correct biomedical concept corresponding to 'fet3p'. Answer using one of the provided options. | <Options>: A: fet4p (saccharomyces cerevisiae s288c) (aka fet4p)
B: fer3 (drosophila melanogaster) (ferritin 3 heavy chain homologue (drosophila melanogaster)) (aka ferritin 3 heavy chain homologue)
C: etf1p3 (homo sapiens) (aka eukaryotic translation termination factor 1 pseudogene 3)
D: fer3-like bhlh transcription factor (xenopus tropicalis) (aka fer3-like bhlh transcription factor)
E: ferroxidase fet3 (saccharomyces cerevisiae s288c) (aka ferroxidase fet3)
F: None of the above. | E |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correct biomedical concept corresponding to 'fet3p'. Answer using one of the provided options. | <Options>: A: transcription factor 3 pseudogene 1 (homo sapiens) (aka transcription factor 3 pseudogene 1)
B: fthl3p (homo sapiens) (aka ferritin heavy chain 1 pseudogene 3)
C: fer3-like bhlh transcription factor (xenopus tropicalis) (aka fer3-like bhlh transcription factor)
D: fer3 (drosophila melanogaster) (ferritin 3 heavy chain homologue (drosophila melanogaster)) (aka ferritin 3 heavy chain homologue)
E: ferry endosomal rab5 effector complex subunit 3 (xenopus tropicalis) (aka ferry endosomal rab5 effector complex subunit 3)
F: None of the above. | F |
<Instruct>: Given the context 'Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt7a (gallus gallus) (aka wnt family member 7a)
B: wnt-7a (homo sapiens) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
D: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
E: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
F: None of the above. | B |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt7a (gallus gallus) (aka wnt family member 7a)
B: wnt-7a (homo sapiens) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
D: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
E: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
F: None of the above. | B |
<Instruct>: Given the context 'This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt7a (homo sapiens) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
D: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
E: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt7a (homo sapiens) (aka wnt family member 7a)
D: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
E: wnt7a (gallus gallus) (aka wnt family member 7a)
F: None of the above. | C |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt family member 7a (gallus gallus) (aka wnt family member 7a)
B: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
D: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
E: wnt7a (homo sapiens) (aka wnt family member 7a)
F: None of the above. | E |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
D: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
E: wnt-7a (homo sapiens) (aka wnt family member 7a)
F: None of the above. | E |
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