instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
E: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
F: None of the above. | E |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
C: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
D: mllt7 (homo sapiens) (aka forkhead box o4)
E: mll (homo sapiens) (aka lysine methyltransferase 2a)
F: None of the above. | E |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
E: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
F: None of the above. | A |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: graf (homo sapiens) (aka rho gtpase activating protein 26)
D: grap (homo sapiens) (aka grb2 related adaptor protein)
E: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
F: None of the above. | F |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept corresponding to 'rhoa'. Answer using one of the provided options. | <Options>: A: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
B: rhoa-a (xenopus laevis) (ras homolog family member a l homeolog (xenopus laevis)) (aka ras homolog family member a l homeolog)
C: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
D: rhoa (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
E: rhoa-a (xenopus laevis) (ras homolog gene family, member a, gene 2 s homeolog (xenopus laevis)) (aka ras homolog gene family, member a, gene 2 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
F: None of the above. | A |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
E: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
F: None of the above. | A |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: grap (homo sapiens) (aka grb2 related adaptor protein)
F: None of the above. | A |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
E: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
F: None of the above. | D |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: grap (homo sapiens) (aka grb2 related adaptor protein)
E: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
F: None of the above. | F |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
F: None of the above. | C |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
E: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
F: None of the above. | E |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccr1'. Answer using one of the provided options. | <Options>: A: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
C: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
E: None of the above. | B |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccr8'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor 8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
F: None of the above. | A |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'liver-expressed chemokine'. Answer using one of the provided options. | <Options>: A: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
D: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
E: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
F: None of the above. | F |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
D: lec1 (drosophila melanogaster) (aka parched)
E: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
F: None of the above. | B |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'lmc'. Answer using one of the provided options. | <Options>: A: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
B: lmc (homo sapiens) (aka c-c motif chemokine ligand 16)
C: lmc (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
D: xcmyc (xenopus laevis) (myc proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis)) (aka myc proto-oncogene, bhlh transcription factor l homeolog)
E: ldc (homo sapiens) (aka lumican)
F: None of the above. | B |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'hcc-4'. Answer using one of the provided options. | <Options>: A: hccs-4 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 20)
B: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
D: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
E: hcc-4 (homo sapiens) (c-c motif chemokine ligand 16 (homo sapiens)) (aka c-c motif chemokine ligand 16)
F: None of the above. | E |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ncc-4'. Answer using one of the provided options. | <Options>: A: ncc-1 (homo sapiens) (aka c-c motif chemokine ligand 13)
B: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
C: ncc4 (homo sapiens) (aka c-c motif chemokine ligand 16)
D: ncc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
E: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccl16'. Answer using one of the provided options. | <Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ck16 (homo sapiens) (aka keratin 16)
C: c-c motif chemokine ligand 16 (homo sapiens) (aka c-c motif chemokine ligand 16)
D: ccl26 (homo sapiens) (aka c-c motif chemokine ligand 26)
E: c-x-c motif chemokine ligand 16 (homo sapiens) (aka c-x-c motif chemokine ligand 16)
F: None of the above. | C |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept corresponding to 'ccl16'. Answer using one of the provided options. | <Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: c-c motif chemokine ligand 16 (sus scrofa) (aka c-c motif chemokine ligand 16)
C: c-x-c motif chemokine ligand 16 (homo sapiens) (aka c-x-c motif chemokine ligand 16)
D: ck16 (homo sapiens) (aka keratin 16)
E: ccl26 (homo sapiens) (aka c-c motif chemokine ligand 26)
F: None of the above. | F |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
E: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
F: None of the above. | E |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
C: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
D: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
E: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
F: None of the above. | C |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept corresponding to 'ccr1'. Answer using one of the provided options. | <Options>: A: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
C: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
D: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
E: None of the above. | B |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept corresponding to 'ccr8'. Answer using one of the provided options. | <Options>: A: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: c-c motif chemokine receptor 8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
E: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
F: None of the above. | B |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
C: lec1 (drosophila melanogaster) (aka parched)
D: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
E: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
F: None of the above. | A |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept corresponding to 'ccr1'. Answer using one of the provided options. | <Options>: A: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
D: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
E: None of the above. | D |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept corresponding to 'ccr8'. Answer using one of the provided options. | <Options>: A: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
E: cmkbr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
F: None of the above. | E |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: lce (homo sapiens) (aka elovl fatty acid elongase 6)
E: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
F: None of the above. | E |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept corresponding to 'rantes'. Answer using one of the provided options. | <Options>: A: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
B: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
C: ccl5 (homo sapiens) (aka c-c motif chemokine ligand 5)
D: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
E: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
F: None of the above. | C |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept corresponding to 'i309'. Answer using one of the provided options. | <Options>: A: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: i-309 (mus musculus) (aka c-c motif chemokine ligand 1)
D: l(2r)ia109 (drosophila melanogaster) (aka jun-related antigen)
E: ib291 (xenopus tropicalis) (aka general transcription factor iii)
F: None of the above. | B |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept corresponding to 'i309'. Answer using one of the provided options. | <Options>: A: vista enhancer hs309 (homo sapiens) (aka vista enhancer hs309)
B: e330027i09 (mus musculus) (aka fibronectin 1)
C: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
D: b4309 (escherichia coli str. k-12 substr. mg1655) (aka n-acetyl-9-o-acetylneuraminate esterase)
E: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
F: None of the above. | F |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
C: lec1 (drosophila melanogaster) (aka parched)
D: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
F: None of the above. | A |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
B: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
C: lec1 (drosophila melanogaster) (aka parched)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
F: None of the above. | D |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
E: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
F: None of the above. | B |
<Instruct>: Given the context 'This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.', select the correct biomedical concept corresponding to 'lec'. Answer using one of the provided options. | <Options>: A: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
B: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
C: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
F: None of the above. | D |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: ataxin-3 (mus musculus) (aka ataxin 3)
D: atxn3 (homo sapiens) (aka ataxin 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | D |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'mjd1'. Answer using one of the provided options. | <Options>: A: mjd1 (homo sapiens) (aka ataxin 3)
B: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
E: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
F: None of the above. | A |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'hhr23a'. Answer using one of the provided options. | <Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
E: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
F: None of the above. | D |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'hhr23b'. Answer using one of the provided options. | <Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
C: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
D: hh2r (homo sapiens) (aka histamine receptor h2)
E: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
F: None of the above. | C |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'mjd1'. Answer using one of the provided options. | <Options>: A: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
B: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: mjds (homo sapiens) (aka lipin 2)
E: mjd (homo sapiens) (aka ataxin 3)
F: None of the above. | E |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin-3 (mus musculus) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin 3 (mus musculus) (aka ataxin 3)
F: None of the above. | F |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: atxn3 (homo sapiens) (aka ataxin 3)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: ataxin 3 (mus musculus) (aka ataxin 3)
F: None of the above. | C |
<Instruct>: Given the context 'However, the normal function of ataxin-3 remains unknown.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 3 (mus musculus) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin 3 (homo sapiens) (aka ataxin 3)
F: None of the above. | E |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: atxn3 (homo sapiens) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin 3 (sus scrofa) (aka ataxin 3)
F: None of the above. | A |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (homo sapiens) (aka ataxin 3)
E: ataxin 3 (sus scrofa) (aka ataxin 3)
F: None of the above. | D |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: ataxin 3 (sus scrofa) (aka ataxin 3)
E: ataxin 3 (homo sapiens) (aka ataxin 3)
F: None of the above. | E |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept corresponding to 'rad23'. Answer using one of the provided options. | <Options>: A: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
B: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
C: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3)
D: rad23p (saccharomyces cerevisiae s288c) (aka rad23p)
E: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept corresponding to 'hhr23a'. Answer using one of the provided options. | <Options>: A: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
B: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
E: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
F: None of the above. | D |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept corresponding to 'hhr23b'. Answer using one of the provided options. | <Options>: A: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
B: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
E: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with the HHR23 proteins through this specific interaction.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin 3 (mus musculus) (aka ataxin 3)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: atxn3 (homo sapiens) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with the HHR23 proteins through this specific interaction.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: ataxin 3 (mus musculus) (aka ataxin 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: atxn3 (homo sapiens) (aka ataxin 3)
F: None of the above. | E |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with the HHR23 proteins through this specific interaction.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | F |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with the HHR23 proteins through this specific interaction.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin 3 (mus musculus) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: None of the above. | C |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: sca3 (homo sapiens) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 3 (mus musculus) (aka ataxin 3)
D: ataxin 3 (sus scrofa) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: None of the above. | A |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept corresponding to 'hhr23a'. Answer using one of the provided options. | <Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
C: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
D: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
E: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
F: None of the above. | E |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (mus musculus) (aka ataxin 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin 3 (sus scrofa) (aka ataxin 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | C |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin-3 (mus musculus) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: ataxin 3 (homo sapiens) (aka ataxin 3)
F: None of the above. | E |
<Instruct>: Given the context 'These results suggest that this interaction is associated with the normal function of ataxin-3 and that some functional abnormality of the HHR23 proteins might exist in MJD.', select the correct biomedical concept corresponding to 'ataxin-3'. Answer using one of the provided options. | <Options>: A: ataxin 3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin 3 (mus musculus) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: None of the above. | A |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
C: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
D: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
E: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
F: None of the above. | A |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept corresponding to 'x-linked retinoschisis protein'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
B: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
C: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: retinoschisin 1 l homeolog (xenopus laevis) (aka retinoschisin 1 l homeolog)
E: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
F: None of the above. | C |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept corresponding to 'x-linked retinoschisis'. Answer using one of the provided options. | <Options>: A: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
D: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
E: retinal dystrophy, x-linked, gardener-hardcastle type (homo sapiens) (aka retinal dystrophy, x-linked, gardener-hardcastle type)
F: None of the above. | A |
<Instruct>: Given the context 'Many missense and protein-truncating mutations of the causative gene RS1 have now been identified and are thought to be inactivating.', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
C: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
D: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
E: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
F: None of the above. | A |
<Instruct>: Given the context 'Many missense and protein-truncating mutations of the causative gene RS1 have now been identified and are thought to be inactivating.', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
B: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
C: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
D: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
E: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
F: None of the above. | F |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
C: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
D: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
E: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
F: None of the above. | A |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
B: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
C: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
D: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
E: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
F: None of the above. | E |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
B: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
C: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
D: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
E: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
F: None of the above. | A |
<Instruct>: Given the context 'A screen of human tissues with this antibody reveals retinoschisin to be retina specific and the antibody detects a protein of similar size in bovine and murine retinae.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
B: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
F: None of the above. | B |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rsc1a1 (homo sapiens) (aka regulator of solute carriers 1)
B: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
F: None of the above. | B |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
D: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
E: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
F: None of the above. | E |
<Instruct>: Given the context 'The antisense riboprobe detected RS1 mRNA only in the photoreceptor layer but the protein product of the gene was present both in the photoreceptors and within the inner portions of the retina.', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
C: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
D: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
E: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept corresponding to 'rs1'. Answer using one of the provided options. | <Options>: A: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
B: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
C: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
D: rsc1a1 (homo sapiens) (aka regulator of solute carriers 1)
E: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
F: None of the above. | E |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
B: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
E: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
F: None of the above. | B |
<Instruct>: Given the context 'These results suggest that retinoschisin is released by photo-receptors and has functions within the inner retinal layers.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
C: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
F: None of the above. | A |
<Instruct>: Given the context 'These results suggest that retinoschisin is released by photo-receptors and has functions within the inner retinal layers.', select the correct biomedical concept corresponding to 'retinoschisin'. Answer using one of the provided options. | <Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
D: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
E: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
F: None of the above. | F |
<Instruct>: Given the context 'Thus, X-linked retinoschisis is caused by abnormalities in a putative secreted photoreceptor protein and is the first example of a secreted photo-receptor protein associated with a retinal dystrophy.', select the correct biomedical concept corresponding to 'x-linked retinoschisis'. Answer using one of the provided options. | <Options>: A: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
B: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
C: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
D: retinal dystrophy, x-linked, gardener-hardcastle type (homo sapiens) (aka retinal dystrophy, x-linked, gardener-hardcastle type)
E: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
F: None of the above. | C |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept corresponding to 'neuronal cdk5 activator'. Answer using one of the provided options. | <Options>: A: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
B: cyclin-dependent kinase 5, regulatory subunit 1 (p35) (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35))
C: p25 (drosophila melanogaster) (cdk5 activator-like protein (drosophila melanogaster)) (aka cdk5 activator-like protein)
D: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
E: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
F: None of the above. | A |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept corresponding to 'cyclin-dependent protein kinase 5'. Answer using one of the provided options. | <Options>: A: cyclin-dependent kinase 5 (xenopus tropicalis) (aka cyclin-dependent kinase 5)
B: cyclin dependent kinase 15 (homo sapiens) (aka cyclin dependent kinase 15)
C: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
D: cyclin dependent kinase 5 (mus musculus) (aka cyclin dependent kinase 5)
E: cyclin dependent kinase like 5 (homo sapiens) (aka cyclin dependent kinase like 5)
F: None of the above. | C |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept corresponding to 'cdk5'. Answer using one of the provided options. | <Options>: A: cdk5 (xenopus laevis) (aka cyclin-dependent kinase 5 l homeolog)
B: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog (xenopus laevis)) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog)
C: cdk5 (mus musculus) (aka cyclin dependent kinase 5)
D: cdk5r (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
E: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
F: None of the above. | E |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept corresponding to 'neuronal cdk5 activator'. Answer using one of the provided options. | <Options>: A: cyclin-dependent kinase 5, regulatory subunit 1 (p35) (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35))
B: p25 (drosophila melanogaster) (cdk5 activator-like protein (drosophila melanogaster)) (aka cdk5 activator-like protein)
C: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
D: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
E: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
F: None of the above. | C |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
B: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
C: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
D: nck (homo sapiens) (aka nck adaptor protein 1)
E: nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000)', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
B: nek5 (homo sapiens) (aka nima related kinase 5)
C: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
D: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
E: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000)', select the correct biomedical concept corresponding to 'c42'. Answer using one of the provided options. | <Options>: A: c82 (homo sapiens) (complement c8 beta chain (homo sapiens)) (aka complement c8 beta chain)
B: c34 (homo sapiens) (aka rna polymerase iii subunit f)
C: c42 (homo sapiens) (complement c4a (chido/rodgers blood group) (homo sapiens)) (aka complement c4a (chido/rodgers blood group))
D: c48 (homo sapiens) (aka cdk5 regulatory subunit associated protein 2)
E: c4b (homo sapiens) (aka complement c4b (chido/rodgers blood group))
F: None of the above. | F |
<Instruct>: Given the context 'A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000)', select the correct biomedical concept corresponding to 'c48'. Answer using one of the provided options. | <Options>: A: mgc148328 (bos taurus) (aka uncharacterized loc783058)
B: c48 (homo sapiens) (aka cdk5 regulatory subunit associated protein 2)
C: c56 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
D: c4a (homo sapiens) (aka complement c4a (chido/rodgers blood group))
E: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
F: None of the above. | B |
<Instruct>: Given the context 'A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000)', select the correct biomedical concept corresponding to 'c53'. Answer using one of the provided options. | <Options>: A: c53 (mus musculus) (aka cdk5 regulatory subunit associated protein 3)
B: c33 (homo sapiens) (aka cd82 molecule)
C: c35a5.13 (caenorhabditis elegans) (aka ncrna)
D: c55c3.73 (caenorhabditis elegans) (aka uncharacterized protein)
E: c35c5.13 (caenorhabditis elegans) (aka ncrna)
F: None of the above. | F |
<Instruct>: Given the context 'A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000)', select the correct biomedical concept corresponding to 'c53'. Answer using one of the provided options. | <Options>: A: c35 (homo sapiens) (aka migration and invasion enhancer 1)
B: c33 (homo sapiens) (aka cd82 molecule)
C: c53 (mus musculus) (aka cdk5 regulatory subunit associated protein 3)
D: c53 (rattus norvegicus) (aka cdk5 regulatory subunit associated protein 3)
E: c53a5.13 (caenorhabditis elegans) (aka fibronectin type-iii domain-containing protein)
F: None of the above. | F |
<Instruct>: Given the context 'The three proteins show competitive binding to Nck5a suggesting that they bind at a common site.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
B: nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: nck (homo sapiens) (aka nck adaptor protein 1)
D: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
E: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
F: None of the above. | B |
<Instruct>: Given the context 'The binding site has been mapped to a region of 26 amino acid residues (residues 145 to 170) at the N-terminal boundary of the kinase activation domain of Nck5a.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
B: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
C: nek5 (homo sapiens) (aka nima related kinase 5)
D: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
E: nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'This region of Nck5a contains an amphipathic alpha-helix whose hydrophobic face is involved in Cdk5 activation (Chin, K. T., Ohki, S, Tang, D., Cheng, H. C., Wang, J. H. , and Zhang, M. (1999) J. Biol.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nek5 (homo sapiens) (aka nima related kinase 5)
B: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
C: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
D: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
E: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'This region of Nck5a contains an amphipathic alpha-helix whose hydrophobic face is involved in Cdk5 activation (Chin, K. T., Ohki, S, Tang, D., Cheng, H. C., Wang, J. H. , and Zhang, M. (1999) J. Biol.', select the correct biomedical concept corresponding to 'cdk5'. Answer using one of the provided options. | <Options>: A: cdk5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
B: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
C: cdk5 (mus musculus) (aka cyclin dependent kinase 5)
D: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
E: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
F: None of the above. | D |
<Instruct>: Given the context 'Several lines of evidence suggest that Nck5a interacts with the binding proteins at the hydrophilic face of the amphipathic alpha-helix.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nek5 (homo sapiens) (aka nima related kinase 5)
B: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
C: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
D: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
E: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
F: None of the above. | D |
<Instruct>: Given the context 'First, the Nck5a-(145-170) peptide can bind Cdk5 and Nck5a-binding proteins simultaneously.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nckalpha (homo sapiens) (aka nck adaptor protein 1)
B: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
C: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
D: nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
E: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
F: None of the above. | D |
<Instruct>: Given the context 'First, the Nck5a-(145-170) peptide can bind Cdk5 and Nck5a-binding proteins simultaneously.', select the correct biomedical concept corresponding to 'cdk5'. Answer using one of the provided options. | <Options>: A: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog (xenopus laevis)) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog)
B: cdk5 (xenopus laevis) (aka cyclin-dependent kinase 5 l homeolog)
C: cdk5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
D: cyclin dependent kinase 5 (homo sapiens) (aka cyclin dependent kinase 5)
E: cdk5 (mus musculus) (aka cyclin dependent kinase 5)
F: None of the above. | D |
<Instruct>: Given the context 'Second, the association of Nck5a-(145-170) to C48 can be markedly reduced by high ionic strength whereas the interaction between Nck5a and Cdk5 is not affected.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nek5 (homo sapiens) (aka nima related kinase 5)
B: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
C: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
D: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
E: nck (homo sapiens) (aka nck adaptor protein 1)
F: None of the above. | C |
<Instruct>: Given the context 'Second, the association of Nck5a-(145-170) to C48 can be markedly reduced by high ionic strength whereas the interaction between Nck5a and Cdk5 is not affected.', select the correct biomedical concept corresponding to 'c48'. Answer using one of the provided options. | <Options>: A: c34 (homo sapiens) (aka rna polymerase iii subunit f)
B: tcce518 (homo sapiens) (aka transmembrane 4 l six family member 20)
C: complement c4a (rodgers blood group)-like (homo sapiens) (aka complement c4a (rodgers blood group)-like)
D: mgc148328 (bos taurus) (aka uncharacterized loc783058)
E: c48 (homo sapiens) (aka cdk5 regulatory subunit associated protein 2)
F: None of the above. | E |
<Instruct>: Given the context 'Second, the association of Nck5a-(145-170) to C48 can be markedly reduced by high ionic strength whereas the interaction between Nck5a and Cdk5 is not affected.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: cb1k5 (homo sapiens) (aka cannabinoid receptor 1)
B: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: nek5 (homo sapiens) (aka nima related kinase 5)
D: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
E: nckalpha (homo sapiens) (aka nck adaptor protein 1)
F: None of the above. | B |
<Instruct>: Given the context 'Second, the association of Nck5a-(145-170) to C48 can be markedly reduced by high ionic strength whereas the interaction between Nck5a and Cdk5 is not affected.', select the correct biomedical concept corresponding to 'nck5a'. Answer using one of the provided options. | <Options>: A: nck5ai (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 2 (p39))
B: nek5 (homo sapiens) (aka nima related kinase 5)
C: nck5ai (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 2)
D: nck (homo sapiens) (aka nck adaptor protein 1)
E: nck-a (xenopus tropicalis) (aka nck adaptor protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'Second, the association of Nck5a-(145-170) to C48 can be markedly reduced by high ionic strength whereas the interaction between Nck5a and Cdk5 is not affected.', select the correct biomedical concept corresponding to 'cdk5'. Answer using one of the provided options. | <Options>: A: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog (xenopus laevis)) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog)
B: cdk5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
C: cdk5 (xenopus laevis) (aka cyclin-dependent kinase 5 l homeolog)
D: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
E: cdk5a (drosophila melanogaster) (aka cdk5 activator-like protein)
F: None of the above. | D |
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