instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
|---|---|---|
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad4 (mus musculus) (aka smad family member 4)
D: smad4 (homo sapiens) (aka smad family member 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | D |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: madh4 (homo sapiens) (aka smad family member 4)
F: None of the above. | E |
<Instruct>: Given the context 'The mutant proteins were found to have impaired abilities to bind DNA although they were fully capable of forming complexes with Smad3.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: smad3 (homo sapiens) (aka smad family member 3)
D: smad family member 3 (mus musculus) (aka smad family member 3)
E: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
F: None of the above. | C |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: smad4 (homo sapiens) (aka smad family member 4)
F: None of the above. | E |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (homo sapiens) (aka smad family member 4)
E: mad4 (homo sapiens) (aka max dimerization protein 4)
F: None of the above. | D |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (homo sapiens) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: smad4 (drosophila melanogaster) (aka medea)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (mus musculus) (aka smad family member 4)
F: None of the above. | A |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: smad family member 3 (homo sapiens) (aka smad family member 3)
D: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
E: smad3 (mus musculus) (aka smad family member 3)
F: None of the above. | C |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: madh4 (homo sapiens) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | A |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | F |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
B: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
E: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad4 (mus musculus) (aka smad family member 4)
C: dpc4 (homo sapiens) (aka smad family member 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | C |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
D: smad family member 3 (homo sapiens) (aka smad family member 3)
E: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: smad3 (mus musculus) (aka smad family member 3)
C: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
D: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
E: smad3 (homo sapiens) (aka smad family member 3)
F: None of the above. | E |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (homo sapiens) (aka smad family member 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: mad4 (homo sapiens) (aka max dimerization protein 4)
F: None of the above. | A |
<Instruct>: Given the context 'In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | B |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: None of the above. | C |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept corresponding to 'doublecortin'. Answer using one of the provided options. | <Options>: A: doublecortin (sus scrofa) (aka doublecortin)
B: doublecortin (bos taurus) (aka doublecortin)
C: dcx (homo sapiens) (aka doublecortin)
D: doublecortin domain containing 2 (homo sapiens) (aka doublecortin domain containing 2)
E: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2)
F: None of the above. | C |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
C: lis3 (homo sapiens) (aka tubulin alpha 1a)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: None of the above. | D |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (rattus norvegicus) (aka doublecortin)
B: dcx (xenopus tropicalis) (aka doublecortin)
C: doublecortin (homo sapiens) (aka doublecortin)
D: dcx (mus musculus) (aka doublecortin)
E: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
F: None of the above. | C |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
E: dcx (rattus norvegicus) (aka doublecortin)
F: None of the above. | F |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'type i lissencephaly'. Answer using one of the provided options. | <Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: lisx (homo sapiens) (aka doublecortin)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lis9 (homo sapiens) (aka microtubule actin crosslinking factor 1)
F: None of the above. | B |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: lis1 (drosophila melanogaster) (aka lissencephaly-1)
F: None of the above. | C |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: doublecortin (rattus norvegicus) (aka doublecortin)
B: dcx (mus musculus) (aka doublecortin)
C: doublecortin (homo sapiens) (aka doublecortin)
D: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
E: doublecortin (xenopus tropicalis) (aka doublecortin)
F: None of the above. | C |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: doublecortin (rattus norvegicus) (aka doublecortin)
B: doublecortin (xenopus tropicalis) (aka doublecortin)
C: dcx (oryctolagus cuniculus) (aka doublecortin)
D: dcx (homo sapiens) (aka doublecortin)
E: dcx (mus musculus) (aka doublecortin)
F: None of the above. | D |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: None of the above. | A |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
B: dcx (oryctolagus cuniculus) (aka doublecortin)
C: dcx (mus musculus) (aka doublecortin)
D: doublecortin (xenopus tropicalis) (aka doublecortin)
E: dcx (homo sapiens) (aka doublecortin)
F: None of the above. | E |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
F: None of the above. | C |
<Instruct>: Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: dcx (homo sapiens) (aka doublecortin)
E: dcx (xenopus tropicalis) (aka doublecortin)
F: None of the above. | D |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: None of the above. | B |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: doublecortin (xenopus tropicalis) (aka doublecortin)
E: dcx (homo sapiens) (aka doublecortin)
F: None of the above. | E |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: dcx (mus musculus) (aka doublecortin)
F: None of the above. | F |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
F: None of the above. | D |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: dcx (xenopus tropicalis) (aka doublecortin)
C: dcx (oryctolagus cuniculus) (aka doublecortin)
D: dcx (mus musculus) (aka doublecortin)
E: dcx (homo sapiens) (aka doublecortin)
F: None of the above. | E |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (rattus norvegicus) (aka doublecortin)
B: dcx (oryctolagus cuniculus) (aka doublecortin)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
E: doublecortin (homo sapiens) (aka doublecortin)
F: None of the above. | E |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: None of the above. | D |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis3 (homo sapiens) (aka tubulin alpha 1a)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (mus musculus) (aka doublecortin)
B: doublecortin (homo sapiens) (aka doublecortin)
C: dcx (rattus norvegicus) (aka doublecortin)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: doublecortin (xenopus tropicalis) (aka doublecortin)
F: None of the above. | B |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
D: lis3 (homo sapiens) (aka tubulin alpha 1a)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
F: None of the above. | E |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcx (mus musculus) (aka doublecortin)
B: dcx (rattus norvegicus) (aka doublecortin)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: doublecortin (homo sapiens) (aka doublecortin)
E: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
F: None of the above. | D |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lis1 (drosophila melanogaster) (aka lissencephaly-1)
F: None of the above. | D |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: None of the above. | C |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
B: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lis3 (homo sapiens) (aka tubulin alpha 1a)
F: None of the above. | F |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lis3 (homo sapiens) (aka tubulin alpha 1a)
F: None of the above. | A |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options. | <Options>: A: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: dcx (homo sapiens) (aka doublecortin)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: dcx (rattus norvegicus) (aka doublecortin)
E: dcx (oryctolagus cuniculus) (aka doublecortin)
F: None of the above. | B |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
C: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
D: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
F: None of the above. | A |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
B: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | E |
<Instruct>: Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
F: None of the above. | D |
<Instruct>: Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
B: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
C: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | D |
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
D: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
E: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
F: None of the above. | C |
<Instruct>: Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | E |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
F: None of the above. | A |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
D: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
F: None of the above. | B |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
F: None of the above. | F |
<Instruct>: Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | D |
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
E: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
F: None of the above. | B |
<Instruct>: Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
C: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | E |
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
B: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
D: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
E: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
F: None of the above. | C |
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options. | <Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
F: None of the above. | D |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'tmprss3'. Answer using one of the provided options. | <Options>: A: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
B: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
C: transmembrane serine protease 3 (homo sapiens) (aka transmembrane serine protease 3)
D: try3 (homo sapiens) (prss3 pseudogene 3 (homo sapiens)) (aka prss3 pseudogene 3)
E: tmprss3 (sus scrofa) (aka transmembrane serine protease 3)
F: None of the above. | C |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'echos1'. Answer using one of the provided options. | <Options>: A: hypertension, essential, susceptibility to, 1 (homo sapiens) (aka hypertension, essential, susceptibility to, 1)
B: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
C: echos1 (homo sapiens) (aka transmembrane serine protease 3)
D: echo virus (serotypes 4, 6, 11, 19) sensitivity (homo sapiens) (aka echo virus (serotypes 4, 6, 11, 19) sensitivity)
E: entr1 (homo sapiens) (aka endosome associated trafficking regulator 1)
F: None of the above. | C |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options. | <Options>: A: dfnb9 (homo sapiens) (aka otoferlin)
B: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
C: dfnb110 (homo sapiens) (aka cochlin)
D: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
E: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
F: None of the above. | B |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'dfnb8'. Answer using one of the provided options. | <Options>: A: dfn6 (homo sapiens) (aka small muscle protein x-linked)
B: dfna8 (homo sapiens) (aka tectorin alpha)
C: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
D: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
E: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
F: None of the above. | D |
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options. | <Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4)
B: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
C: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
D: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
E: dfnb9 (homo sapiens) (aka otoferlin)
F: None of the above. | D |
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options. | <Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4)
B: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
C: dfnb9 (homo sapiens) (aka otoferlin)
D: dfnb110 (homo sapiens) (aka cochlin)
E: dfnb109 (homo sapiens) (aka epithelial splicing regulatory protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept corresponding to 'dfnb8'. Answer using one of the provided options. | <Options>: A: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
B: dfnb9 (homo sapiens) (aka otoferlin)
C: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
D: dfna8 (homo sapiens) (aka tectorin alpha)
E: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
F: None of the above. | A |
<Instruct>: Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
B: fancb (homo sapiens) (aka fa complementation group b)
C: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
E: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
F: None of the above. | D |
<Instruct>: Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
C: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: fancd2 (homo sapiens) (aka fa complementation group d2)
E: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
F: None of the above. | A |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
B: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: fancd2 (homo sapiens) (aka fa complementation group d2)
E: fancb (homo sapiens) (aka fa complementation group b)
F: None of the above. | A |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
E: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
F: None of the above. | F |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept corresponding to 'brca2-associated factor 35'. Answer using one of the provided options. | <Options>: A: fsap35 (homo sapiens) (aka tho complex subunit 6)
B: dnaaf15 (homo sapiens) (aka pih1 domain containing 2)
C: saga complex associated factor 29 (homo sapiens) (aka saga complex associated factor 29)
D: formation of mitochondrial complex v assembly factor 1 homolog (xenopus tropicalis) (aka formation of mitochondrial complex v assembly factor 1 homolog)
E: saga complex associated factor 29 (xenopus tropicalis) (aka saga complex associated factor 29)
F: None of the above. | F |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf35 (homo sapiens) (aka high mobility group 20b)
B: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
D: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
E: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
F: None of the above. | A |
<Instruct>: Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf35 (homo sapiens) (aka high mobility group 20b)
B: braf35 (mus musculus) (aka high mobility group 20b)
C: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
E: braf2 (homo sapiens) (aka braf pseudogene 1)
F: None of the above. | A |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: palb2 (homo sapiens) (aka partner and localizer of brca2)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
E: fancb (homo sapiens) (aka fa complementation group b)
F: None of the above. | D |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: braf2 (homo sapiens) (aka braf pseudogene 1)
C: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
D: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
E: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf25 (homo sapiens) (aka high mobility group 20b)
B: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
E: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
F: None of the above. | F |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
B: braf35 (mus musculus) (aka high mobility group 20b)
C: braf2 (homo sapiens) (aka braf pseudogene 1)
D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
E: braf25 (homo sapiens) (aka high mobility group 20b)
F: None of the above. | E |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
C: palb2 (homo sapiens) (aka partner and localizer of brca2)
D: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
E: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
F: None of the above. | B |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options. | <Options>: A: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
C: fancb (homo sapiens) (aka fa complementation group b)
D: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
E: palb2 (homo sapiens) (aka partner and localizer of brca2)
F: None of the above. | D |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options. | <Options>: A: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
B: braf35 (homo sapiens) (aka high mobility group 20b)
C: braf35 (mus musculus) (aka high mobility group 20b)
D: braf2 (homo sapiens) (aka braf pseudogene 1)
E: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
F: None of the above. | B |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
B: nkx6a (homo sapiens) (aka nk6 homeobox 1)
C: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
D: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
E: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
F: None of the above. | E |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options. | <Options>: A: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
B: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
C: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
D: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
E: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
F: None of the above. | C |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'gtx'. Answer using one of the provided options. | <Options>: A: gtx (drosophila melanogaster) (aka syntaxin 18)
B: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
C: gcx-1 (xenopus tropicalis) (aka tox high mobility group box family member 2)
D: gtx (mus musculus) (aka nk6 homeobox 2)
E: gta (xenopus laevis) (aka integrin subunit alpha 2b s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
C: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
B: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
D: nkx6a (homo sapiens) (aka nk6 homeobox 1)
E: nkx3b (homo sapiens) (aka nk3 homeobox 2)
F: None of the above. | B |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options. | <Options>: A: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
B: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
C: nkx6b (homo sapiens) (aka nk6 homeobox 2)
D: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options. | <Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
B: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
D: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
E: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
F: None of the above. | F |
<Instruct>: Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
B: nkx6a (homo sapiens) (aka nk6 homeobox 1)
C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
D: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx6b (homo sapiens) (aka nk6 homeobox 2)
B: nkx3b (homo sapiens) (aka nk3 homeobox 2)
C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
D: nkx6a (homo sapiens) (aka nk6 homeobox 1)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options. | <Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6a (homo sapiens) (aka nk6 homeobox 1)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
D: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
E: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
F: None of the above. | D |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept corresponding to 'cd58'. Answer using one of the provided options. | <Options>: A: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
B: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: cd58 molecule (homo sapiens) (aka cd58 molecule)
D: cd52 molecule (homo sapiens) (aka cd52 molecule)
E: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
F: None of the above. | C |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: cd2 molecule (bos taurus) (aka cd2 molecule)
D: cd22 molecule (homo sapiens) (aka cd22 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
F: None of the above. | B |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd4'. Answer using one of the provided options. | <Options>: A: cd4 molecule (homo sapiens) (aka cd4 molecule)
B: integrin subunit alpha 4 (homo sapiens) (aka integrin subunit alpha 4)
C: cd4 (gallus gallus) (aka cd4 molecule)
D: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
E: cd4 (bos taurus) (aka cd4 molecule)
F: None of the above. | A |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd58'. Answer using one of the provided options. | <Options>: A: cd5 molecule (homo sapiens) (aka cd5 molecule)
B: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
D: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
E: cd58 molecule (homo sapiens) (aka cd58 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: cd2 molecule (bos taurus) (aka cd2 molecule)
C: cd228 (homo sapiens) (aka melanotransferrin)
D: cd2 (homo sapiens) (aka cd2 molecule)
E: cd21 (homo sapiens) (aka complement c3d receptor 2)
F: None of the above. | D |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'fos'. Answer using one of the provided options. | <Options>: A: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
B: fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
D: fos (mus musculus) (aka fbj osteosarcoma oncogene)
E: fra (homo sapiens) (fos like 1, ap-1 transcription factor subunit (homo sapiens)) (aka fos like 1, ap-1 transcription factor subunit)
F: None of the above. | B |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
D: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
E: juno (homo sapiens) (aka izumo1 receptor, juno)
F: None of the above. | C |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options. | <Options>: A: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: juno (homo sapiens) (aka izumo1 receptor, juno)
D: jun (mus musculus) (aka jun proto-oncogene)
E: None of the above. | E |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: il-2 (homo sapiens) (aka interleukin 2)
E: interleukin 3 (homo sapiens) (aka interleukin 3)
F: None of the above. | D |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept corresponding to 'c-fos'. Answer using one of the provided options. | <Options>: A: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
D: fos (mus musculus) (aka fbj osteosarcoma oncogene)
E: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
F: None of the above. | A |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd2 (bos taurus) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: cd2 (homo sapiens) (aka cd2 molecule)
F: None of the above. | E |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.