instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options. | <Options>: A: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: interleukin 2 (homo sapiens) (aka interleukin 2)
F: N... | E |
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: cd22 molecule (homo sapiens) (aka cd22 molecule)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd2 molecule (homo sapiens) (aka cd2 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: cd2 (bos taurus) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: cd21 (homo sapiens) (aka complement c3d receptor 2)
F: None of the above. | B |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd2 (bos taurus) (aka cd2 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: cd2 (gallus gallus) (aka cd2 molecule)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd21 (homo sapiens) (aka complement c3d receptor 2)
F: None of the above. | D |
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options. | <Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: cd2 (gallus gallus) (aka cd2 molecule)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: None of the above. | D |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept corresponding to 'mammalian target of rapamycin'. Answer using one of the provided options. | <Options>: A: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
B: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
C: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
D: mtor (drosophila mel... | F |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options. | <Options>: A: mtor (mus musculus) (aka mechanistic target of rapamycin kinase)
B: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
D: mechanistic targe... | F |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options. | <Options>: A: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
B: mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
D: ... | F |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept corresponding to 'alpha1 ampk'. Answer using one of the provide... | <Options>: A: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
B: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit)
C: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 2)
D: prot... | F |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept corresponding to 'alpha2 ampk'. Answer using one of the provide... | <Options>: A: ampkalpha2 (mus musculus) (aka protein kinase, amp-activated, alpha 2 catalytic subunit)
B: alpha kinase 2 (homo sapiens) (aka alpha kinase 2)
C: ampka2 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
D: ampk alpha 1 (homo sapiens) (aka protein kinase amp-activated catalytic su... | F |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Options>: A: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase)
B: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
D: mtor (drosophi... | F |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Options>: A: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
B: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
C: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
D:... | F |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Options>: A: mtor (mus musculus) (aka mechanistic target of rapamycin kinase)
B: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
C: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
D: mtor (homo sapi... | F |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Options>: A: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
B: rps6ka6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
C: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6)
D: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
E: s6kbeta (homo... | F |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept corresponding to 'eif4e'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
B: eif4e (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
C: eif4ep1 (homo sapiens) (aka eukaryo... | F |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept corresponding to 'eif4g'. Answer using one of the provided options. | <Options>: A: eif4g (xenopus laevis) (eukaryotic translation initiation factor 4 gamma, 1 s homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4 gamma, 1 s homeolog)
B: eif4g (xenopus tropicalis) (aka eukaryotic translation initiation factor 4 gamma, 1)
C: eif4gl (homo sapiens) (aka cwc22 spliceos... | F |
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept corresponding to 'eif2b'. Answer using one of the provided options. | <Options>: A: eif2b1 (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit alpha)
B: eif2beta (homo sapiens) (aka eukaryotic translation initiation factor 2 subunit beta)
C: eif2b (drosophila melanogaster) (eukaryotic translation initiation factor 2b subunit beta (drosophila melanogaster)) (aka eukary... | E |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: pcdh7 (homo sapiens) (aka protocadherin 7)
F: None of the abo... | F |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: pcdh7 (homo sapiens) (aka protocadherin 7)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
F: None of the above. | F |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
F: None of the ab... | F |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin 10 (homo sapiens) (aka protocadherin 10)
E: pcdhac (homo sapiens) (aka protocadherin alpha constant)
F: None of the abov... | F |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: pcdh7 (homo sapiens) (aka protocadherin 7)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
E: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
F: None of the above. | F |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: protocadherin 10 (homo sapiens) (aka protocadherin 10)
E: pcdhac (homo sapiens) (aka protocadherin alpha constant)
F: None ... | F |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Ans... | <Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: pcdh7 (homo sapiens) (aka protocadherin 7)
F: None of the above... | F |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: protocadherin 10 (homo sapiens) (aka protocadherin 10)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
F: None of... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: tmem205 (mus musculus) (aka transmembrane protein 205)
B: tmem205 (sus scrofa) (aka transmembrane protein 205)
C: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
D: tmem205 (xenopus tropicalis) (aka transmembrane protein 205)
E: mast205 (homo sapiens) (aka microtubule associa... | E |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: transmembrane protein 205 (mus musculus) (aka transmembrane protein 205)
B: microtubule associated serine/threonine kinase 2 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
C: mstp105 (homo sapiens) (aka early endosome antigen 1)
D: microtubule associated serine/threonine kinase 1 (h... | B |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: protocadherin 10 (homo sapiens) (aka protocadherin 10)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: pcdhac (homo sapiens) (aka protocadherin alpha constant)
F: None of the ab... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
B: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
C: tmem205 (mus musculus) (aka transmembrane protein 205)
D: transmembrane protein 205 (sus scrofa) (aka transmembrane protein 205)
E: tmem205 (xeno... | B |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
B: mast 205 (drosophila melanogaster) (aka drop out)
C: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
D: tmem205 (mus musculus) (aka transmembrane protein 205)
E: tmem205 (homo sapiens) (aka transm... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: protocadherin 7 (homo sapiens) (aka protocadherin 7)
E: protocadherin 1 (homo sapiens) (aka protocadherin 1)
F: None of the above. | F |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the prov... | <Options>: A: protocadherin 7 (homo sapiens) (aka protocadherin 7)
B: pcdhac (homo sapiens) (aka protocadherin alpha constant)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: protocadherin 10 (homo sapiens) (aka protocadherin 10)
F: None of the above. | F |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept corresponding to 'pdz protein'. Answer using one of the provided o... | <Options>: A: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
B: pdz domain containing 1 (homo sapiens) (aka pdz domain containing 1)
C: pdzx (homo sapiens) (aka magi family member, x-linked)
D: pdz73 (homo sapiens) (aka ush1 protein network component harmonin)
E: pd... | F |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: daxx (xenopus tropicalis) (aka death-associated protein 6)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: dax1 (homo sapiens) (aka nuclear receptor subfamily 0 gr... | A |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'histone deacetylase ii'. Answer using one of the provided options. | <Options>: A: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
D: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
E: histone deacetylase 2 (xenopus tropicalis) (aka ... | B |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'chromatin-associated protein dek'. Answer using one of the provided options. | <Options>: A: dek proto-oncogene (mus musculus) (aka dek proto-oncogene)
B: dek (xenopus tropicalis) (aka dek proto-oncogene)
C: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
D: dek (danio rerio) (aka dek proto-oncogene)
E: dek7 (drosophila melanogaster) (aka eph receptor tyrosine kinase)
F: None of the ab... | C |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (mus musculus) (aka fas death domain-associated p... | B |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx (homo sapiens) (aka death domain associated protein)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (danio rerio) (aka death-domain associated protein)
... | B |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: daxx (homo sapiens) (aka death domain associated protein)
E: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
F: ... | D |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx (homo sapiens) (aka death domain associated protein)
C: hyrax (drosophila melanogaster) (aka hyrax)
D: adx (homo sapiens) (aka ferredoxin 1)
E: axed on x (drosophila melanogaster) (aka axed on x)
F: None of the above. | B |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: axed on x (drosophila melanogaster) (aka axed on x)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: hyrax (drosophila melanogaster) (aka hyrax)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | F |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: adx (homo sapiens) (aka ferredoxin 1)
E: hyrax (drosophila melanogaster) (aka hyrax)
F: No... | B |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: hyrax (drosophila melanogaster) (aka hyrax)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (xenopus tropicalis) (aka death-associated protein 6)
F: None of... | B |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Options>: A: axed on x (drosophila melanogaster) (aka axed on x)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | B |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Options>: A: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
B: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
C: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
D: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
E: histone deacetylase 2 (homo ... | E |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided ... | <Options>: A: hyrax (drosophila melanogaster) (aka hyrax)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | B |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept corresponding to 'histone deacetylase ii'. Answer using one... | <Options>: A: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
B: histone deacetylase 2 (homo sapiens) (aka histone deacetylase 2)
C: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
D: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
E: histone deacetylase 1 (homo ... | B |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (danio rerio) (aka death-domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx (homo sapiens) (aka death domain associated protein)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | D |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: daxx (homo sapiens) (aka death domain associated protein)
D: adx (homo sapiens) (aka ferredoxin 1)
E: daxx (xenopus tropicalis) (aka death-associated protein 6)
F... | C |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: daxx (xenopus tropicalis) (aka death-associated protein 6)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: hyrax (drosophila melanogaster) (aka hyrax)
E: daxx (homo sapiens) (aka death domain associated protein)
F: None of the above. | E |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: separase (saccharomyces cerevisiae s288c) (aka separase)
E: esp1 (homo sapiens) (extra spind... | E |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (drosophila melanogaster) (aka separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole bodies like 1, separase (xenopus tropicalis) (ak... | F |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: securin (caenorhabditis elegans) (aka securin)
D: pttg1 regulator o... | D |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (drosophila melanogaster) (aka separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle... | C |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: separase (drosophila melano... | B |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: securin (caenorhabditis elegans) (aka securin)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
D: sec62 homolog, preprotein translocation factor s homeolog (xen... | C |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole b... | A |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: separase (sac... | B |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies l... | B |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies like 1, separase ... | A |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: homolog of separase (arabidopsis thaliana) (aka separase)
E: separase (candida albi... | A |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole bodies like 1, separase (xenopus tropical... | C |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: separase (drosophila melanogaster) (aka separase)
E: homolog... | F |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
C: securin (xenopus laevis) (aka securin)
D: securin (oryctolagus cuniculus) (aka securin)
E: ptt... | A |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (drosophila melanogaster) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra sp... | D |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: securin (oryctolagus cuniculus) (aka securin)
D: securin-like protein (caenorhabditis elegans) (aka securin-like... | A |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (candida albicans sc5314) (aka separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: separase (drosophila melanogaster) (aka separase)
E: extra spindle pole bodies 1, ... | A |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, s... | B |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid sepa... | B |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: separase (... | A |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: separase (drosophila melanogaster) (aka separase)
C: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
D: separase (saccharomyces cerevisiae s288c) (aka separase)
E: extra spindle pole bod... | C |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of si... | E |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: ho... | B |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like ... | F |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: extra spindle pole bodies like 1, separase (homo sapiens) (aka extr... | D |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid se... | C |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)... | A |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: extra spindle pole bod... | E |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: separase (candida albicans sc5314) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: separin homolog sep-1 (caenorhabditis elegans) (aka separin ... | C |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
B: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
D: interleukin 2 receptor... | B |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
C: cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens)) (aka cd3 gamma subu... | C |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame prot... | D |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept corresponding to 'icam-1'. Answer using one ... | <Options>: A: cell adhesion molecule 1 (homo sapiens) (aka cell adhesion molecule 1)
B: icam4 (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
C: icam1 (homo sapiens) (aka intercellular adhesion molecule 1)
D: icam3 (homo sapiens) (aka intercellular adhesion molecule 3)
E: icam5 (... | C |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
B: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
C: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
D: cd3... | E |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor compl... | F |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: adam metallopeptidase domain 10 (homo sapiens) (aka adam metallopeptidase domain 10)
B: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
D: adam9 (homo sapiens) (aka adam metal... | A |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept corresponding to 'l1 adhesion molecule'. Answer using one of the provided options. | <Options>: A: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: n-cam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
E: lethal (1) l1 (drosophila melanogas... | D |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1.1 (mus musculus) (aka skull morphology 1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: ... | D |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
E: lethal (1) l1 (drosophila melanogaster) (aka let... | B |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: l1 c... | D |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: adam metallopeptidase domain 10 (homo sapiens) (aka adam metallopeptidase domain 10)
B: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
E: adam-ts10 (homo sapiens) (aka a... | A |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled re... | E |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: l(... | C |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: ad10 (homo sapiens) (adam metallopepti... | C |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecu... | B |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1.1 (mus musculus) (aka... | F |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: l1.1 (mus musculus) (aka skull morphology 1)
D: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
E: ad... | B |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: l1 cell adhesion molecule (homo sapiens) (... | D |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 (drosophila melanogaster) (retroactive (drosophila melanogast... | E |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
C: l1.1 (mus musculus) (aka skull morphology 1)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion mol... | E |
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