instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'We report the novel finding that CXCR3 is also expressed on CD34(+) hematopoietic progenitors from human cord blood stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) but not on freshly isolated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'granulocyte-macrophage colony-stimulating factor'. Answer using one of the provided options. | <Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: colony stimulating factor 3 (granulocyte) (mus musculus) (aka colony stimulating factor 3 (granulocyte))
C: myeloid derived growth factor (homo sapiens) (aka myeloid derived growth factor)
D: csf-1 (homo sapiens) (aka colony stimulating factor 1)
E: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
F: None of the above. | A |
<Instruct>: Given the context 'We report the novel finding that CXCR3 is also expressed on CD34(+) hematopoietic progenitors from human cord blood stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) but not on freshly isolated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
B: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
C: csf1 (homo sapiens) (aka colony stimulating factor 1)
D: csf2 (homo sapiens) (aka colony stimulating factor 2)
E: multi-csf (homo sapiens) (aka interleukin 3)
F: None of the above. | D |
<Instruct>: Given the context 'We report the novel finding that CXCR3 is also expressed on CD34(+) hematopoietic progenitors from human cord blood stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) but not on freshly isolated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
B: cd34 (gallus gallus) (aka cd34 molecule)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd34 (sus scrofa) (aka cd34 molecule)
E: fat4 (homo sapiens) (aka fat atypical cadherin 4)
F: None of the above. | A |
<Instruct>: Given the context 'Freshly isolated CD34(+) progenitors expressed low levels of CXCR3 messenger RNA, but this expression was highly up-regulated by GM-CSF, as indicated by a real-time quantitative reverse transcriptase-polymerase chain reaction technique.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: cd344 (homo sapiens) (aka frizzled class receptor 4)
F: None of the above. | D |
<Instruct>: Given the context 'Freshly isolated CD34(+) progenitors expressed low levels of CXCR3 messenger RNA, but this expression was highly up-regulated by GM-CSF, as indicated by a real-time quantitative reverse transcriptase-polymerase chain reaction technique.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
C: cd34 (sus scrofa) (aka cd34 molecule)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
F: None of the above. | F |
<Instruct>: Given the context 'Freshly isolated CD34(+) progenitors expressed low levels of CXCR3 messenger RNA, but this expression was highly up-regulated by GM-CSF, as indicated by a real-time quantitative reverse transcriptase-polymerase chain reaction technique.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | D |
<Instruct>: Given the context 'Freshly isolated CD34(+) progenitors expressed low levels of CXCR3 messenger RNA, but this expression was highly up-regulated by GM-CSF, as indicated by a real-time quantitative reverse transcriptase-polymerase chain reaction technique.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: multi-csf (homo sapiens) (aka interleukin 3)
B: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: il-10a (homo sapiens) (aka interleukin 10)
B: il-10c (homo sapiens) (aka interleukin 19)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig9 (homo sapiens) (aka s100 calcium binding protein p)
B: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
E: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | B |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: csf (homo sapiens) (colony stimulating factor 2 (homo sapiens)) (aka colony stimulating factor 2)
B: csf-1 (homo sapiens) (aka colony stimulating factor 1)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: multi-csf (homo sapiens) (aka interleukin 3)
E: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
F: None of the above. | A |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 (gallus gallus) (aka cd34 molecule)
F: None of the above. | B |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
F: None of the above. | A |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
C: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: il-10a (homo sapiens) (aka interleukin 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | C |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: mig9 (homo sapiens) (aka s100 calcium binding protein p)
C: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
D: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
E: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
F: None of the above. | A |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | F |
<Instruct>: Given the context 'gamma IP-10 and Mig induced chemotaxis of GM-CSF-stimulated CD34(+) progenitors by means of CXCR3, since an anti-CXCR3 monoclonal antibody (mAb) was found to block gamma IP-10-induced and Mig-induced CD34(+) progenitor chemotaxis.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 (sus scrofa) (aka cd34 molecule)
B: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
E: cd344 (homo sapiens) (aka frizzled class receptor 4)
F: None of the above. | B |
<Instruct>: Given the context 'These chemotactic attracted CD34(+)', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: fat4 (homo sapiens) (aka fat atypical cadherin 4)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 (sus scrofa) (aka cd34 molecule)
F: None of the above. | A |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: interleukin 10 (homo sapiens) (aka interleukin 10)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
E: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | E |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: csf1 (homo sapiens) (aka colony stimulating factor 1)
B: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
C: multi-csf (homo sapiens) (aka interleukin 3)
D: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
E: gmcsf (homo sapiens) (aka colony stimulating factor 2)
F: None of the above. | E |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: cd344 (homo sapiens) (aka frizzled class receptor 4)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
D: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
E: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | E |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: None of the above. | C |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'gammaip-10'. Answer using one of the provided options. | <Options>: A: interleukin 10 (homo sapiens) (aka interleukin 10)
B: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: pla2g10ip (homo sapiens) (aka phospholipase a2 group xi, pseudogene)
D: cd2f-10 (homo sapiens) (aka slam family member 9)
E: il-10c (homo sapiens) (aka interleukin 19)
F: None of the above. | B |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
B: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
E: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | C |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
D: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
E: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | F |
<Instruct>: Given the context 'gamma IP-10 and Mig also induced GM-CSF-stimulated CD34(+) progenitor adhesion and aggregation by means of CXCR3, a finding confirmed by the observation that anti-CXCR3 mAb blocked these functions of gammaIP-10 and Mig but not of chemokine stromal cell-derived factor 1 alpha.', select the correct biomedical concept corresponding to 'chemokine stromal cell-derived factor 1 alpha'. Answer using one of the provided options. | <Options>: A: sdf-5 (homo sapiens) (aka secreted frizzled related protein 2)
B: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
C: stromal cell derived factor 2 (homo sapiens) (aka stromal cell derived factor 2)
D: sdf1 (homo sapiens) (aka c-x-c motif chemokine ligand 12)
E: sdf2l1 (homo sapiens) (aka stromal cell derived factor 2 like 1)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | B |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
E: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
F: None of the above. | C |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'cd49a'. Answer using one of the provided options. | <Options>: A: integrin subunit alpha 9 (homo sapiens) (aka integrin subunit alpha 9)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: cd49fa (homo sapiens) (aka integrin subunit alpha 6)
D: cd49a (homo sapiens) (aka integrin subunit alpha 1)
E: glycoprotein ix platelet (homo sapiens) (aka glycoprotein ix platelet)
F: None of the above. | D |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'cd49b'. Answer using one of the provided options. | <Options>: A: cd49b (homo sapiens) (aka integrin subunit alpha 2)
B: cd42b (homo sapiens) (aka glycoprotein ib platelet subunit alpha)
C: cd41b (homo sapiens) (aka integrin subunit alpha 2b)
D: cd49c (homo sapiens) (aka integrin subunit alpha 3)
E: cd49d (homo sapiens) (aka integrin subunit alpha 4)
F: None of the above. | A |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: csf1 (homo sapiens) (aka colony stimulating factor 1)
B: multi-csf (homo sapiens) (aka interleukin 3)
C: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
D: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
E: gmcsf (homo sapiens) (aka colony stimulating factor 2)
F: None of the above. | E |
<Instruct>: Given the context 'gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+)', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 (sus scrofa) (aka cd34 molecule)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: il-10c (homo sapiens) (aka interleukin 19)
D: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | A |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
B: mig9 (homo sapiens) (aka s100 calcium binding protein p)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
D: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | F |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
B: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
C: csf (homo sapiens) (colony stimulating factor 2 (homo sapiens)) (aka colony stimulating factor 2)
D: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
E: multi-csf (homo sapiens) (aka interleukin 3)
F: None of the above. | C |
<Instruct>: Given the context 'Moreover, gamma IP-10 and Mig stimulated CXCR3 redistribution and cellular polarization in GM-CSF-stimulated CD34(+) progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: fat4 (homo sapiens) (aka fat atypical cadherin 4)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 (sus scrofa) (aka cd34 molecule)
F: None of the above. | A |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
B: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
C: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
D: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | E |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'gamma ip-10'. Answer using one of the provided options. | <Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: il-10c (homo sapiens) (aka interleukin 19)
E: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | E |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
E: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
F: None of the above. | A |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
B: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
C: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
F: None of the above. | D |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'gm-csf'. Answer using one of the provided options. | <Options>: A: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
B: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
C: csf1 (homo sapiens) (aka colony stimulating factor 1)
D: multi-csf (homo sapiens) (aka interleukin 3)
E: gmcsf (homo sapiens) (aka colony stimulating factor 2)
F: None of the above. | E |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progenitors into lymphoid and myeloid stem cells, subsequently immune and inflammatory cells.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: cd34 molecule (gallus gallus) (aka cd34 molecule)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 molecule (homo sapiens) (aka cd34 molecule)
F: None of the above. | E |
<Instruct>: Given the context 'These processes include transmigration, relocation, differentiation, and maturation of CD34(+) hematopoietic progenitors.', select the correct biomedical concept corresponding to 'cd34'. Answer using one of the provided options. | <Options>: A: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: cd34 (sus scrofa) (aka cd34 molecule)
D: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
E: cd34 molecule (gallus gallus) (aka cd34 molecule)
F: None of the above. | D |
<Instruct>: Given the context 'HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
', select the correct biomedical concept corresponding to 'gp120'. Answer using one of the provided options. | <Options>: A: envelope glycoprotein n (human alphaherpesvirus 1) (aka envelope glycoprotein n)
B: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
C: envelope glycoprotein c (human alphaherpesvirus 1) (aka envelope glycoprotein c)
D: envelope surface glycoprotein gp160, precursor (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
E: nef (human immunodeficiency virus 1) (aka nef)
F: None of the above. | D |
<Instruct>: Given the context 'HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
', select the correct biomedical concept corresponding to 'gp120'. Answer using one of the provided options. | <Options>: A: vpr (human immunodeficiency virus 1) (aka vpr)
B: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
C: gp120 (drosophila melanogaster) (aka golgi complex-localized glycoprotein 1)
D: gag (human immunodeficiency virus 1) (aka pr55(gag))
E: vif (human immunodeficiency virus 1) (aka vif)
F: None of the above. | F |
<Instruct>: Given the context 'HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
', select the correct biomedical concept corresponding to 'gp160'. Answer using one of the provided options. | <Options>: A: envelope glycoprotein 150 (human gammaherpesvirus 4) (aka envelope glycoprotein 150)
B: envelope surface glycoprotein gp160, precursor (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
C: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
D: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
E: tmem160 (homo sapiens) (aka transmembrane protein 160)
F: None of the above. | B |
<Instruct>: Given the context 'Recently, the alpha-chemokine receptor CXCR4 has been reported to mediate apoptosis in neuronal cells and in CD4(+) and CD8(+) T cells after its binding to HIV-1 envelope proteins.', select the correct biomedical concept corresponding to 'alpha-chemokine receptor cxcr4'. Answer using one of the provided options. | <Options>: A: x-c motif chemokine receptor 1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: atypical chemokine receptor 4 (xenopus tropicalis) (aka atypical chemokine receptor 4)
C: cxcr4 (homo sapiens) (aka c-x-c motif chemokine receptor 4)
D: chemokine (c motif) receptor 1 (xenopus tropicalis) (aka chemokine (c motif) receptor 1)
E: c-x-c motif chemokine receptor 4 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 4)
F: None of the above. | C |
<Instruct>: Given the context 'In the current study, it was observed that human umbilical vein endothelial cells (HUVEC) undergo apoptosis after their treatment with the HIV-1 envelope proteins gp120/160.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
B: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
C: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
D: mg160 (homo sapiens) (aka golgi glycoprotein 1)
E: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
F: None of the above. | B |
<Instruct>: Given the context 'Anti-CXCR4 monoclonal antibody decreased HIV-1 gp120/160-induced apoptosis, suggesting that the CXCR4 chemokine receptor mediates the apoptotic effects of these HIV envelope glycoproteins.', select the correct biomedical concept corresponding to 'cxcr4'. Answer using one of the provided options. | <Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: chemokine (c motif) receptor 1 (xenopus tropicalis) (aka chemokine (c motif) receptor 1)
C: cxcr4 (homo sapiens) (aka c-x-c motif chemokine receptor 4)
D: c-c chemokine receptor type 8 (xenopus tropicalis) (aka c-c chemokine receptor type 8)
E: atypical chemokine receptor 4 (xenopus tropicalis) (aka atypical chemokine receptor 4)
F: None of the above. | C |
<Instruct>: Given the context 'Anti-CXCR4 monoclonal antibody decreased HIV-1 gp120/160-induced apoptosis, suggesting that the CXCR4 chemokine receptor mediates the apoptotic effects of these HIV envelope glycoproteins.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
B: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
C: envelope surface glycoprotein gp160, precursor (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
D: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
E: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
F: None of the above. | C |
<Instruct>: Given the context 'Anti-CXCR4 monoclonal antibody decreased HIV-1 gp120/160-induced apoptosis, suggesting that the CXCR4 chemokine receptor mediates the apoptotic effects of these HIV envelope glycoproteins.', select the correct biomedical concept corresponding to 'cxcr4'. Answer using one of the provided options. | <Options>: A: chemokine (c motif) receptor 1 (xenopus tropicalis) (aka chemokine (c motif) receptor 1)
B: atypical chemokine receptor 4 (xenopus tropicalis) (aka atypical chemokine receptor 4)
C: cxcr4 (homo sapiens) (aka c-x-c motif chemokine receptor 4)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: cxcr4 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 4)
F: None of the above. | C |
<Instruct>: Given the context 'Further studies revealed that caspases play an important role in this process because the pretreatment of cells with a general caspase enzyme inhibitor decreased the extent of HUVEC apoptosis induced by gp120/160.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
B: gp160 (homo sapiens) (aka glutamyl aminopeptidase)
C: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
D: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
E: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, it was found that caspase-3 was activated on HIV-1 gp120/160 treatment of these cells.', select the correct biomedical concept corresponding to 'caspase-3'. Answer using one of the provided options. | <Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: caspase-3 (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
C: caspase 3 (homo sapiens) (aka caspase 3)
D: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
E: caspase-3 (mus musculus) (aka caspase 3)
F: None of the above. | C |
<Instruct>: Given the context 'In addition, it was found that caspase-3 was activated on HIV-1 gp120/160 treatment of these cells.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
B: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
C: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
D: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
E: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
F: None of the above. | B |
<Instruct>: Given the context 'It was also observed that gp120/160 treatment slightly increased the expression of the pro-apoptotic molecule Bax.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: gp160 (homo sapiens) (aka glutamyl aminopeptidase)
B: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
C: mg160 (homo sapiens) (aka golgi glycoprotein 1)
D: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
E: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
F: None of the above. | D |
<Instruct>: Given the context 'It was also observed that gp120/160 treatment slightly increased the expression of the pro-apoptotic molecule Bax.', select the correct biomedical concept corresponding to 'gp120/160'. Answer using one of the provided options. | <Options>: A: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
B: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
C: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
D: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
E: gp160 (homo sapiens) (aka glutamyl aminopeptidase)
F: None of the above. | F |
<Instruct>: Given the context 'It was also observed that gp120/160 treatment slightly increased the expression of the pro-apoptotic molecule Bax.', select the correct biomedical concept corresponding to 'bax'. Answer using one of the provided options. | <Options>: A: bak-2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
B: bcl-x (homo sapiens) (aka bcl2 like 1)
C: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
D: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
E: bak-like (homo sapiens) (aka bcl2 antagonist/killer 1)
F: None of the above. | D |
<Instruct>: Given the context 'These results suggest that HIV-1 envelope glycoproteins can disrupt endothelial integrity through the interaction with CXCR4, thereby facilitating virus transit out of the bloodstream and contributing to the vascular injury syndromes seen in acquired immunodeficiency syndrome.', select the correct biomedical concept corresponding to 'cxcr4'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 4 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 4)
B: c-c chemokine receptor type 8 (xenopus tropicalis) (aka c-c chemokine receptor type 8)
C: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
D: cxcr4 (homo sapiens) (aka c-x-c motif chemokine receptor 4)
E: chemokine (c motif) receptor 1 (xenopus tropicalis) (aka chemokine (c motif) receptor 1)
F: None of the above. | D |
<Instruct>: Given the context 'Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome).
', select the correct biomedical concept corresponding to 'collagen xviii'. Answer using one of the provided options. | <Options>: A: collagen type xviii alpha 1 chain (homo sapiens) (aka collagen type xviii alpha 1 chain)
B: collagen type xviii alpha 1 chain (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
C: collagen type xviii alpha 1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
D: collagen alpha-1(xxviii) chain (xenopus tropicalis) (aka collagen alpha-1(xxviii) chain)
E: collagen type xviii alpha 1 s homeolog (xenopus laevis) (aka collagen type xviii alpha 1 s homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'We reconstructed the haplotypes of this family with ten additional markers (five were novel) and narrowed the candidate interval to a region of < 245 kb, which contains 24 expressed sequence tags, the KIAA0958 gene and the 5' end of the COL18A1 gene.', select the correct biomedical concept corresponding to 'kiaa0958'. Answer using one of the provided options. | <Options>: A: c17orf58 homolog (gallus gallus) (aka c17orf58 homolog)
B: kiaa0759 (homo sapiens) (aka angel homolog 1)
C: kiaa0859 (homo sapiens) (aka methyltransferase 13, eef1a n-terminus and k55)
D: chromosome 10 c17orf58 homolog (xenopus tropicalis) (aka chromosome 10 c17orf58 homolog)
E: chromosome 9 c21orf58 ortholog (xenopus tropicalis) (aka chromosome 9 c21orf58 ortholog)
F: None of the above. | F |
<Instruct>: Given the context 'We reconstructed the haplotypes of this family with ten additional markers (five were novel) and narrowed the candidate interval to a region of < 245 kb, which contains 24 expressed sequence tags, the KIAA0958 gene and the 5' end of the COL18A1 gene.', select the correct biomedical concept corresponding to 'col18a1'. Answer using one of the provided options. | <Options>: A: col18a1a (danio rerio) (aka collagen type xviii alpha 1 chain a)
B: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
C: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
D: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
E: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
F: None of the above. | D |
<Instruct>: Given the context 'We identified a homozygous mutation at the AG consensus acceptor splice site of COL18A1 intron 1 exclusively among the 12 KS patients, which was not found among 140 control chromosomes.', select the correct biomedical concept corresponding to 'col18a1'. Answer using one of the provided options. | <Options>: A: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
B: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
C: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
D: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
E: col18a1 (oryctolagus cuniculus) (aka collagen type xviii alpha 1 chain)
F: None of the above. | A |
<Instruct>: Given the context 'This mutation predicts the creation of a stop codon in exon 4 and therefore the truncation of the alpha1(XVIII) collagen short form, which was expressed in human adult retina.', select the correct biomedical concept corresponding to 'alpha1(xviii) collagen'. Answer using one of the provided options. | <Options>: A: collagen alpha-1(xxviii) chain (xenopus laevis) (aka collagen alpha-1(xxviii) chain)
B: collagen type xxviii alpha 1 chain (homo sapiens) (aka collagen type xxviii alpha 1 chain)
C: collagen alpha-1(xvi) chain (homo sapiens) (aka collagen alpha-1(xvi) chain)
D: collagen type xviii alpha 1 chain (homo sapiens) (aka collagen type xviii alpha 1 chain)
E: collagen type xviii alpha 1 chain (sus scrofa) (aka collagen type xviii alpha 1 chain)
F: None of the above. | D |
<Instruct>: Given the context 'These findings provide evidence that KS is caused by mutations in COL18A1 which, therefore, has a major role in determining the retinal structure as well as in the closure of the neural tube.', select the correct biomedical concept corresponding to 'col18a1'. Answer using one of the provided options. | <Options>: A: col18a1.s (xenopus laevis) (aka collagen type xviii alpha 1 s homeolog)
B: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
C: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
D: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
E: col18a1 (xenopus laevis) (aka collagen type xviii alpha 1 l homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: clk (homo sapiens) (aka cdc like kinase 1)
B: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
C: ciks (homo sapiens) (aka traf3 interacting protein 2)
D: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
E: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
F: None of the above. | C |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'ikkalpha'. Answer using one of the provided options. | <Options>: A: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
B: ikk1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
D: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
F: None of the above. | B |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'ikkalpha'. Answer using one of the provided options. | <Options>: A: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
C: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
D: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
E: None of the above. | E |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'ikkbeta'. Answer using one of the provided options. | <Options>: A: ikbkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
C: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
D: ikkbeta (mus musculus) (aka inhibitor of kappab kinase beta)
E: None of the above. | A |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'nemo'. Answer using one of the provided options. | <Options>: A: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
B: nemep (mus musculus) (aka small integral membrane protein 43)
C: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
D: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
E: nemo like kinase (mus musculus) (aka nemo like kinase)
F: None of the above. | D |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'nf-kappab essential modulator'. Answer using one of the provided options. | <Options>: A: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
B: immunoglobulin kappa deleting element or like (homo sapiens) (aka immunoglobulin kappa deleting element or like)
C: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
D: nemo (drosophila melanogaster) (aka nemo)
E: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
F: None of the above. | C |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept corresponding to 'ikkgamma'. Answer using one of the provided options. | <Options>: A: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
B: ikkgamma (drosophila melanogaster) (aka kenny)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: ikk-gamma (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
F: None of the above. | E |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
D: ciks (homo sapiens) (aka traf3 interacting protein 2)
E: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
F: None of the above. | D |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept corresponding to 'nemo'. Answer using one of the provided options. | <Options>: A: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
B: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
C: nope (mus musculus) (aka immunoglobulin superfamily, dcc subclass, member 4)
D: nemo like kinase (mus musculus) (aka nemo like kinase)
E: nemep (mus musculus) (aka small integral membrane protein 43)
F: None of the above. | A |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept corresponding to 'ikkgamma'. Answer using one of the provided options. | <Options>: A: ikk-gamma (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
B: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
C: ikkgammabeta (drosophila melanogaster) (aka kenny)
D: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
F: None of the above. | A |
<Instruct>: Given the context 'When ectopically expressed, CIKS stimulates IKK and SAPK/JNK kinases and it transactivates an NF-kappaB-dependent reporter.', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
B: ciks (homo sapiens) (aka traf3 interacting protein 2)
C: csk (homo sapiens) (aka c-terminal src kinase)
D: ciks (mus musculus) (aka traf3 interacting protein 2)
E: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
F: None of the above. | B |
<Instruct>: Given the context 'CIKS may help to connect upstream signaling events to IKK and SAPK/JNK modules.', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: ciks (homo sapiens) (aka traf3 interacting protein 2)
D: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
E: clk (homo sapiens) (aka cdc like kinase 1)
F: None of the above. | C |
<Instruct>: Given the context 'CIKS could coordinate the activation of two stress-induced signaling pathways, functions reminiscent of those noted for tumor necrosis factor receptor-associated factor adaptor proteins.', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
D: ciks (homo sapiens) (aka traf3 interacting protein 2)
E: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
F: None of the above. | D |
<Instruct>: Given the context 'CIKS could coordinate the activation of two stress-induced signaling pathways, functions reminiscent of those noted for tumor necrosis factor receptor-associated factor adaptor proteins.', select the correct biomedical concept corresponding to 'ciks'. Answer using one of the provided options. | <Options>: A: ciks (mus musculus) (aka traf3 interacting protein 2)
B: clk (homo sapiens) (aka cdc like kinase 1)
C: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
D: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: None of the above. | F |
<Instruct>: Given the context 'Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad4 (homo sapiens) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | C |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
E: smad3 (mus musculus) (aka smad family member 3)
F: None of the above. | D |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad4 (mus musculus) (aka smad family member 4)
D: madh4 (homo sapiens) (aka smad family member 4)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | D |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: madh4 (homo sapiens) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | B |
<Instruct>: Given the context 'The mutant proteins were found to have impaired abilities to bind DNA although they were fully capable of forming complexes with Smad3.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
E: smad3 (homo sapiens) (aka smad family member 3)
F: None of the above. | E |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad4 (homo sapiens) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 4 (mus musculus) (aka smad family member 4)
F: None of the above. | B |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad4 (mus musculus) (aka smad family member 4)
F: None of the above. | B |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: madh4 (homo sapiens) (aka smad family member 4)
C: smad4 (drosophila melanogaster) (aka medea)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: mad4 (homo sapiens) (aka max dimerization protein 4)
F: None of the above. | B |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (homo sapiens) (aka smad family member 3)
B: smad3 (mus musculus) (aka smad family member 3)
C: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
D: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
E: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: smad4 (mus musculus) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (homo sapiens) (aka smad family member 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad4 (mus musculus) (aka smad family member 4)
F: None of the above. | F |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (mus musculus) (aka smad family member 3)
B: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
C: madh3 (homo sapiens) (aka smad family member 3)
D: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
E: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: madh4 (homo sapiens) (aka smad family member 4)
C: smad4 (drosophila melanogaster) (aka medea)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad family member 5 (homo sapiens) (aka smad family member 5)
F: None of the above. | B |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
C: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
D: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
E: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
F: None of the above. | B |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad3'. Answer using one of the provided options. | <Options>: A: smad family member 3 (homo sapiens) (aka smad family member 3)
B: smad family member 3 (mus musculus) (aka smad family member 3)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
E: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
F: None of the above. | A |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: madh4 (homo sapiens) (aka smad family member 4)
F: None of the above. | E |
<Instruct>: Given the context 'In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (homo sapiens) (aka smad family member 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | A |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options. | <Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
F: None of the above. | E |
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