instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical concept corresponding to 'interleukin-1 receptor antagonist'. Answer using one of the provided options. | <Options>: A: il1rp1 (homo sapiens) (aka interleukin 37)
B: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
C: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
D: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
E: il-1rn (homo sapiens) (aka interleukin 1 receptor antagonist)
F: None of the above. | E |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: interleukin 1 receptor antagonist (homo sapiens) (aka interleukin 1 receptor antagonist)
B: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
C: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
D: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
E: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'The gene contains four exons which code for the secreted form of the IL-1ra, however, our clone does not contain the alternative first exon used to generate an intracellular form of the protein as the protein as found in epithelial cells.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: il1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
D: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
E: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the above. | C |
<Instruct>: Given the context 'By in-situ fluorescence hybridization we have shown that the IL-1ra gene is found on the long arm of chromosome 2 and maps to 2q13-14.1.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
B: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
C: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
D: interleukin 1 receptor antagonist (homo sapiens) (aka interleukin 1 receptor antagonist)
E: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the above. | D |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 alpha'. Answer using one of the provided options. | <Options>: A: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
B: il-1a (homo sapiens) (aka interleukin 1 alpha)
C: il-1 (homo sapiens) (aka interleukin 1 beta)
D: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
E: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 alpha'. Answer using one of the provided options. | <Options>: A: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
B: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
C: il-1 (homo sapiens) (aka interleukin 1 beta)
D: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
E: None of the above. | E |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 beta'. Answer using one of the provided options. | <Options>: A: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
B: il-1 (homo sapiens) (aka interleukin 1 beta)
C: ifnb1 (homo sapiens) (aka interferon beta 1)
D: None of the above. | B |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin-like (arabidopsis thaliana) (aka aprataxin-like protein)
B: aprataxin-like (xenopus laevis) (aka aprataxin-like)
C: aprataxin (homo sapiens) (aka aprataxin)
D: aprataxin (sus scrofa) (aka aprataxin)
E: aprataxin (xenopus tropicalis) (aka aprataxin)
F: None of the above. | C |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
C: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
D: eoaha (homo sapiens) (aka aprataxin)
E: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
F: None of the above. | D |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'early-onset ataxia with ocular motor apraxia and hypoalbuminemia'. Answer using one of the provided options. | <Options>: A: etaa16 (homo sapiens) (aka etaa1 activator of atr kinase)
B: eaoh (homo sapiens) (aka aprataxin)
C: episodic ataxia, type 7 (homo sapiens) (aka episodic ataxia, type 7)
D: episodic ataxia, type 8 (homo sapiens) (aka episodic ataxia, type 8)
E: epilepsy, occipitotemporal lobe, and migraine with aura (homo sapiens) (aka epilepsy, occipitotemporal lobe, and migraine with aura)
F: None of the above. | B |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
C: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
D: eoaha (homo sapiens) (aka aprataxin)
E: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
F: None of the above. | D |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: eaoh (homo sapiens) (aka aprataxin)
B: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
C: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
D: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
E: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
F: None of the above. | A |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptl (homo sapiens) (aka fas ligand)
B: aptx (xenopus tropicalis) (aka aprataxin)
C: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death receptor s homeolog)
D: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
E: aptx (homo sapiens) (aka aprataxin)
F: None of the above. | E |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
B: aptl (homo sapiens) (aka fas ligand)
C: aptx (homo sapiens) (aka aprataxin)
D: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death receptor s homeolog)
E: aptx (mus musculus) (aka aprataxin)
F: None of the above. | C |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptx (drosophila melanogaster) (aka aprataxin)
B: aptx (xenopus tropicalis) (aka aprataxin)
C: aptx (mus musculus) (aka aprataxin)
D: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death receptor s homeolog)
E: aptx (homo sapiens) (aka aprataxin)
F: None of the above. | E |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
B: aprataxin-like (arabidopsis thaliana) (aka aprataxin-like protein)
C: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
D: aprataxin (homo sapiens) (aka aprataxin)
E: aprataxin (drosophila melanogaster) (aka aprataxin)
F: None of the above. | D |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
B: aprataxin-like (xenopus laevis) (aka aprataxin-like)
C: aprataxin (xenopus tropicalis) (aka aprataxin)
D: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
E: aprataxin (drosophila melanogaster) (aka aprataxin)
F: None of the above. | F |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin-like protein (arabidopsis thaliana) (aka aprataxin-like protein)
B: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
C: aprataxin (xenopus tropicalis) (aka aprataxin)
D: aprataxin (drosophila melanogaster) (aka aprataxin)
E: aprataxin (homo sapiens) (aka aprataxin)
F: None of the above. | E |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin-like protein (arabidopsis thaliana) (aka aprataxin-like protein)
B: aprataxin (drosophila melanogaster) (aka aprataxin)
C: aprataxin (homo sapiens) (aka aprataxin)
D: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
E: aprataxin-like (xenopus laevis) (aka aprataxin-like)
F: None of the above. | C |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept corresponding to 'xrcc1'. Answer using one of the provided options. | <Options>: A: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: xrcc1 (xenopus tropicalis) (x-ray repair complementing defective repair in chinese hamster cells 1 (xenopus tropicalis)) (aka x-ray repair complementing defective repair in chinese hamster cells 1)
C: xrcc9 (homo sapiens) (aka fa complementation group g)
D: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 l homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 l homeolog)
E: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
F: None of the above. | A |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept corresponding to 'x-ray repair cross-complementing group 1'. Answer using one of the provided options. | <Options>: A: homolog of x-ray repair cross complementing 1 (arabidopsis thaliana) (aka brct domain-containing dna repair protein)
B: x-ray repair cross complementing 1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
C: x-ray repair cross complementing 1 (sus scrofa) (aka x-ray repair cross complementing 1)
D: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
E: x-ray repair cross complementing 6 (homo sapiens) (aka x-ray repair cross complementing 6)
F: None of the above. | D |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA ligase III.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
B: aprataxin (drosophila melanogaster) (aka aprataxin)
C: aprataxin (sus scrofa) (aka aprataxin)
D: aprataxin (homo sapiens) (aka aprataxin)
E: aprataxin-like (xenopus laevis) (aka aprataxin-like)
F: None of the above. | D |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA ligase III.', select the correct biomedical concept corresponding to 'polynucleotidekinase-3'-phosphatase'. Answer using one of the provided options. | <Options>: A: polynucleotide kinase 3'-phosphatase (xenopus tropicalis) (aka polynucleotide kinase 3'-phosphatase)
B: polynucleotide kinase 3'- phosphatase (mus musculus) (aka polynucleotide kinase 3'- phosphatase)
C: pnk (homo sapiens) (polynucleotide kinase 3'-phosphatase (homo sapiens)) (aka polynucleotide kinase 3'-phosphatase)
D: polynucleotide kinase 3'-phosphatase s homeolog (xenopus laevis) (aka polynucleotide kinase 3'-phosphatase s homeolog)
E: polynucleotide kinase 3'-phosphatase (bos taurus) (aka polynucleotide kinase 3'-phosphatase)
F: None of the above. | C |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA ligase III.', select the correct biomedical concept corresponding to 'xrcc1'. Answer using one of the provided options. | <Options>: A: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
C: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 l homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 l homeolog)
D: xrcc1 (xenopus tropicalis) (x-ray repair complementing defective repair in chinese hamster cells 1 (xenopus tropicalis)) (aka x-ray repair complementing defective repair in chinese hamster cells 1)
E: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 s homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA ligase III.', select the correct biomedical concept corresponding to 'dna polymerase beta'. Answer using one of the provided options. | <Options>: A: polb (homo sapiens) (dna polymerase beta (homo sapiens)) (aka dna polymerase beta)
B: polg-beta (homo sapiens) (aka dna polymerase gamma 2, accessory subunit)
C: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
D: dna polymerase gamma, catalytic subunit (homo sapiens) (aka dna polymerase gamma, catalytic subunit)
E: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
F: None of the above. | A |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA ligase III.', select the correct biomedical concept corresponding to 'dna ligase iii'. Answer using one of the provided options. | <Options>: A: dna ligase 3 (oryctolagus cuniculus) (aka dna ligase 3)
B: ligase iii, dna, atp-dependent (xenopus tropicalis) (aka ligase iii, dna, atp-dependent)
C: ligase iv, dna, atp-dependent (xenopus tropicalis) (aka ligase iv, dna, atp-dependent)
D: ligase i, dna, atp-dependent (xenopus tropicalis) (aka ligase i, dna, atp-dependent)
E: lig3 (homo sapiens) (dna ligase 3 (homo sapiens)) (aka dna ligase 3)
F: None of the above. | E |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin (sus scrofa) (aka aprataxin)
B: aprataxin (homo sapiens) (aka aprataxin)
C: aprataxin (drosophila melanogaster) (aka aprataxin)
D: aprataxin (mus musculus) (aka aprataxin)
E: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
F: None of the above. | B |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin (drosophila melanogaster) (aka aprataxin)
B: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
C: aprataxin (mus musculus) (aka aprataxin)
D: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
E: aprataxin-like (xenopus laevis) (aka aprataxin-like)
F: None of the above. | F |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the correct biomedical concept corresponding to 'xrcc1'. Answer using one of the provided options. | <Options>: A: xrcc1 (xenopus tropicalis) (regulator of chromosome condensation 1 (xenopus tropicalis)) (aka regulator of chromosome condensation 1)
B: xrcc9 (homo sapiens) (aka fa complementation group g)
C: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
D: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 s homeolog)
E: xrcc11 (homo sapiens) (aka brca2 dna repair associated)
F: None of the above. | C |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
B: etaa1 activator of atr kinase (homo sapiens) (aka etaa1 activator of atr kinase)
C: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
D: eaoh (homo sapiens) (aka aprataxin)
E: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
F: None of the above. | D |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apak (homo sapiens) (aka zinc finger protein 420)
B: apa-1 (homo sapiens) (aka zinc finger protein 410)
C: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
E: apaf-3 (homo sapiens) (aka caspase 9)
F: None of the above. | C |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf3 (homo sapiens) (aka caspase 9)
C: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
D: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
E: apak (homo sapiens) (aka zinc finger protein 420)
F: None of the above. | D |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept corresponding to 'cytochrome c'. Answer using one of the provided options. | <Options>: A: cytochrome c, somatic (oryctolagus cuniculus) (aka cytochrome c, somatic)
B: cytochrome c, somatic (homo sapiens) (aka cytochrome c, somatic)
C: cytochrome c, somatic (xenopus tropicalis) (aka cytochrome c, somatic)
D: cytochrome c, testis-specific (oryctolagus cuniculus) (aka cytochrome c, testis-specific)
E: mitochondrially encoded cytochrome c oxidase iii (homo sapiens) (aka mitochondrially encoded cytochrome c oxidase iii)
F: None of the above. | B |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept corresponding to 'caspase-9'. Answer using one of the provided options. | <Options>: A: casp7 (homo sapiens) (aka caspase 7)
B: caspase-9 (mus musculus) (aka caspase 9)
C: casp9 (homo sapiens) (aka caspase 9)
D: caspase-9 (xenopus tropicalis) (aka caspase 9)
E: casp-8 (homo sapiens) (aka caspase 8)
F: None of the above. | C |
<Instruct>: Given the context 'It has been shown that epigenetic silencing of the APAF-1 gene is a common event in several metastatic melanoma cells in vitro.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apa-1 (homo sapiens) (aka zinc finger protein 410)
C: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
D: apaf3 (homo sapiens) (aka caspase 9)
E: apak (homo sapiens) (aka zinc finger protein 420)
F: None of the above. | A |
<Instruct>: Given the context 'We determined, by Western blot, variation in the level of expression of APAF-1 in several human melanoma cell lines and, by immunohistochemistry, in a group of 106 histological samples including benign and malignant melanocytic lesions.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apa1 (homo sapiens) (aka zinc finger protein 410)
B: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: apaf3 (homo sapiens) (aka caspase 9)
D: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
F: None of the above. | B |
<Instruct>: Given the context 'We observed APAF-1 down-regulation or loss of expression in two metastatic melanoma cell lines, compared to primary melanoma cell lines.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apak (homo sapiens) (aka zinc finger protein 420)
D: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
F: None of the above. | D |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
C: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
D: apak (homo sapiens) (aka zinc finger protein 420)
E: apaf-3 (homo sapiens) (aka caspase 9)
F: None of the above. | A |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
B: apak (homo sapiens) (aka zinc finger protein 420)
C: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
D: apa-1 (homo sapiens) (aka zinc finger protein 410)
E: apaf-3 (homo sapiens) (aka caspase 9)
F: None of the above. | F |
<Instruct>: Given the context 'In addition, we found a significant negative correlation between APAF-1 expression level and tumor thickness and between primary melanomas and metastases.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apak (homo sapiens) (aka zinc finger protein 420)
C: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
D: apaf-3 (homo sapiens) (aka caspase 9)
E: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
F: None of the above. | E |
<Instruct>: Given the context 'We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma.', select the correct biomedical concept corresponding to 'apaf-1'. Answer using one of the provided options. | <Options>: A: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apa-1 (homo sapiens) (aka zinc finger protein 410)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
E: apak (homo sapiens) (aka zinc finger protein 420)
F: None of the above. | A |
<Instruct>: Given the context 'A human cDNA was cloned that encodes a DNA-binding protein (SATB1) that is expressed predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating DNAs (MARs/SARs).', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
B: satb1 (homo sapiens) (aka satb homeobox 1)
C: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
D: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
E: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
F: None of the above. | B |
<Instruct>: Given the context 'Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A's, T's, and C's, excluding G's (ATC sequences).', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: satb1 (homo sapiens) (aka satb homeobox 1)
D: satb1 (rattus norvegicus) (aka satb homeobox 1)
E: satb2 (bos taurus) (aka satb homeobox 2)
F: None of the above. | C |
<Instruct>: Given the context 'When this feature is destroyed by mutation, SATB1 binding is greatly reduced even if the direct contact sequence remains intact.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 (bos taurus) (aka satb homeobox 1)
B: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
C: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
D: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
E: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
F: None of the above. | C |
<Instruct>: Given the context 'Conjunctional SATB1-binding sequences become stably unpaired in supercoiled DNA.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 (bos taurus) (aka satb homeobox 1)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: satb2 (bos taurus) (aka satb homeobox 2)
F: None of the above. | B |
<Instruct>: Given the context 'Specific mutations that diminish the unwinding potential greatly reduce SATB1 binding.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 (homo sapiens) (aka satb homeobox 1)
B: satb2 (bos taurus) (aka satb homeobox 2)
C: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
D: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
E: satb1 (sus scrofa) (aka satb homeobox 1)
F: None of the above. | A |
<Instruct>: Given the context 'However, SATB1 does not bind single-stranded DNA.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb2 (bos taurus) (aka satb homeobox 2)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
D: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
E: satb1 (bos taurus) (aka satb homeobox 1)
F: None of the above. | C |
<Instruct>: Given the context 'Chemical interference assays show that SATB1 binds along the minor groove with very little contact with the bases.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb1 (homo sapiens) (aka satb homeobox 1)
C: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
D: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
E: satb2 (bos taurus) (aka satb homeobox 2)
F: None of the above. | B |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb1 (homo sapiens) (aka satb homeobox 1)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
D: satb1 (bos taurus) (aka satb homeobox 1)
E: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
F: None of the above. | A |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept corresponding to 'satb1'. Answer using one of the provided options. | <Options>: A: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: satb1 (sus scrofa) (aka satb homeobox 1)
D: satb2 (bos taurus) (aka satb homeobox 2)
E: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
F: None of the above. | F |
<Instruct>: Given the context 'Cloning and characterization of a human angiotensin II type 1 receptor.
', select the correct biomedical concept corresponding to 'angiotensin ii type 1 receptor'. Answer using one of the provided options. | <Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
C: at2r1 (homo sapiens) (aka angiotensin ii receptor type 1)
D: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
E: None of the above. | C |
<Instruct>: Given the context 'A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe.', select the correct biomedical concept corresponding to 'type 1 angiotensin ii receptor'. Answer using one of the provided options. | <Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: at2r1 (homo sapiens) (aka angiotensin ii receptor type 1)
C: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
D: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
E: None of the above. | D |
<Instruct>: Given the context 'Ligand binding studies of the cloned receptor expressed in COS cells suggested that it is pharmacologically a type 1 angiotensin II receptor subtype.', select the correct biomedical concept corresponding to 'type 1 angiotensin ii receptor'. Answer using one of the provided options. | <Options>: A: at1br (homo sapiens) (aka angiotensin ii receptor type 1)
B: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
C: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
D: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
E: None of the above. | A |
<Instruct>: Given the context 'A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11.', select the correct biomedical concept corresponding to 'p54'. Answer using one of the provided options. | <Options>: A: p104 (homo sapiens) (aka natural killer cell triggering receptor)
B: d54 (homo sapiens) (aka tpd52 like 2)
C: p54a (homo sapiens) (aka mitogen-activated protein kinase 9)
D: nk-p44 (homo sapiens) (aka natural cytotoxicity triggering receptor 2)
E: p54 (rattus norvegicus) (aka nucleobindin 2)
F: None of the above. | F |
<Instruct>: Given the context 'The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila.', select the correct biomedical concept corresponding to 'me31b'. Answer using one of the provided options. | <Options>: A: mg33b (mus musculus) (aka transmembrane protein 38b)
B: me31b (drosophila melanogaster) (aka maternal expression at 31b)
C: tmem132b (mus musculus) (aka transmembrane protein 132b)
D: me31b (xenopus tropicalis) (aka dead-box helicase 6)
E: family with sequence similarity 131, member b (mus musculus) (aka family with sequence similarity 131, member b)
F: None of the above. | B |
<Instruct>: Given the context 'Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.', select the correct biomedical concept corresponding to 'me31b'. Answer using one of the provided options. | <Options>: A: krt33b (mus musculus) (aka keratin 33b)
B: me31b (xenopus tropicalis) (aka dead-box helicase 6)
C: me31b (drosophila melanogaster) (aka maternal expression at 31b)
D: sec31 homolog b, copii coat complex component (mus musculus) (aka sec31 homolog b, copii coat complex component)
E: family with sequence similarity 131, member b (mus musculus) (aka family with sequence similarity 131, member b)
F: None of the above. | C |
<Instruct>: Given the context 'Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
', select the correct biomedical concept corresponding to 'n-myc'. Answer using one of the provided options. | <Options>: A: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
B: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
D: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
E: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
F: None of the above. | A |
<Instruct>: Given the context 'The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
C: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
D: heew1 (homo sapiens) (aka ectopic p-granules 5 autophagy tethering factor)
E: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
F: None of the above. | A |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept corresponding to 'hlh462'. Answer using one of the provided options. | <Options>: A: lethal (1) eshs46 (drosophila melanogaster) (aka lethal (1) eshs46)
B: lethal (2) 46f4 (drosophila melanogaster) (aka lethal (2) 46f4)
C: lethal (1) g0462 (drosophila melanogaster) (aka lethal (1) g0462)
D: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
E: vista enhancer hs472 (homo sapiens) (aka vista enhancer hs472)
F: None of the above. | D |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept corresponding to 'id'. Answer using one of the provided options. | <Options>: A: iddmx (homo sapiens) (aka diabetes mellitus, insulin-dependent, x-linked, susceptibility to)
B: id1 (danio rerio) (aka inhibitor of dna binding 1, hlh protein)
C: id (mus musculus) (aka atpase, class i, type 8b, member 2)
D: iddpn (homo sapiens) (aka nudix hydrolase 2)
E: idx-1 (homo sapiens) (aka pancreatic and duodenal homeobox 1)
F: None of the above. | C |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept corresponding to 'id'. Answer using one of the provided options. | <Options>: A: iddmx (homo sapiens) (aka diabetes mellitus, insulin-dependent, x-linked, susceptibility to)
B: iddpn (homo sapiens) (aka nudix hydrolase 2)
C: iddhisd (homo sapiens) (aka transportin 2)
D: ids (homo sapiens) (aka iduronate 2-sulfatase)
E: idx-1 (homo sapiens) (aka pancreatic and duodenal homeobox 1)
F: None of the above. | F |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept corresponding to 'emc'. Answer using one of the provided options. | <Options>: A: emc (drosophila melanogaster) (aka extra macrochaetae)
B: emc-1 (caenorhabditis elegans) (aka er membrane protein complex subunit 1;wd_repeats_region domain-containing protein)
C: emc1 (homo sapiens) (aka er membrane protein complex subunit 1)
D: emc-3 (caenorhabditis elegans) (aka er membrane protein complex subunit 3)
E: evc (mus musculus) (aka evc ciliary complex subunit 1)
F: None of the above. | A |
<Instruct>: Given the context 'Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: he1 (homo sapiens) (aka npc intracellular cholesterol transporter 2)
B: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhibitor of dna binding 3, hlh protein l homeolog)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
E: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
F: None of the above. | C |
<Instruct>: Given the context 'Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
B: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhibitor of dna binding 3, hlh protein l homeolog)
E: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
F: None of the above. | C |
<Instruct>: Given the context 'Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: he1 (homo sapiens) (aka npc intracellular cholesterol transporter 2)
B: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
C: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
D: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
E: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
F: None of the above. | E |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heed (homo sapiens) (aka embryonic ectoderm development)
B: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
C: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
D: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
E: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
F: None of the above. | E |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept corresponding to 'n-myc'. Answer using one of the provided options. | <Options>: A: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
C: n-myc (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
D: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
E: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
F: None of the above. | B |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
B: heed (homo sapiens) (aka embryonic ectoderm development)
C: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
D: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
E: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
F: None of the above. | D |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept corresponding to 'n-myc'. Answer using one of the provided options. | <Options>: A: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
D: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
E: n-myc (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
F: None of the above. | D |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
B: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
E: heed (homo sapiens) (aka embryonic ectoderm development)
F: None of the above. | C |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: heew1 (homo sapiens) (aka ectopic p-granules 5 autophagy tethering factor)
B: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
C: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
D: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
E: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
F: None of the above. | D |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept corresponding to 'heir-1'. Answer using one of the provided options. | <Options>: A: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
B: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
C: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhibitor of dna binding 3, hlh protein l homeolog)
D: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
E: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
F: None of the above. | F |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept corresponding to 'n-myc'. Answer using one of the provided options. | <Options>: A: n-myc (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
D: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
E: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
F: None of the above. | D |
<Instruct>: Given the context 'Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
', select the correct biomedical concept corresponding to 'hnrnp u'. Answer using one of the provided options. | <Options>: A: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
E: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
F: None of the above. | C |
<Instruct>: Given the context 'The hnRNP U protein is an abundant nucleoplasmic phosphoprotein that is the largest of the major hnRNP proteins (120 kDa by SDS-PAGE).', select the correct biomedical concept corresponding to 'hnrnp u'. Answer using one of the provided options. | <Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
C: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
F: None of the above. | D |
<Instruct>: Given the context 'HnRNP U binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro.', select the correct biomedical concept corresponding to 'hnrnp u'. Answer using one of the provided options. | <Options>: A: heterogeneous nuclear ribonucleoprotein u (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
C: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
E: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
F: None of the above. | A |
<Instruct>: Given the context 'Here we describe the cloning and sequencing of a cDNA encoding the hnRNP U protein, the determination of its amino acid sequence and the delineation of a region in this protein that confers RNA binding.', select the correct biomedical concept corresponding to 'hnrnp u'. Answer using one of the provided options. | <Options>: A: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
B: heterogeneous nuclear ribonucleoprotein u (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
D: hnrpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
F: None of the above. | D |
<Instruct>: Given the context 'The predicted amino acid sequence of hnRNP U contains 806 amino acids (88,939 Daltons), and shows no extensive homology to any known proteins.', select the correct biomedical concept corresponding to 'hnrnp u'. Answer using one of the provided options. | <Options>: A: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
D: hnrnp u (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
F: None of the above. | D |
<Instruct>: Given the context 'Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
', select the correct biomedical concept corresponding to 'cytoskeletal protein 4.1'. Answer using one of the provided options. | <Options>: A: erythrocyte membrane protein band 4.2 (homo sapiens) (aka erythrocyte membrane protein band 4.2)
B: erythrocyte membrane protein band 4.1 (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1)
C: erythrocyte membrane protein band 4.1 (homo sapiens) (aka erythrocyte membrane protein band 4.1)
D: erythrocyte membrane protein band 4.1 like 1 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 1)
E: erythrocyte membrane protein band 4.1-like 1 (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1-like 1)
F: None of the above. | C |
<Instruct>: Given the context 'We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG.', select the correct biomedical concept corresponding to 'ptpase meg'. Answer using one of the provided options. | <Options>: A: pgp (mus musculus) (phosphoglycolate phosphatase (mus musculus)) (aka phosphoglycolate phosphatase)
B: ptp-pest (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 12)
C: ptpmeg (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 4)
D: ptpmeg (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
E: ptp-meg (drosophila melanogaster) (aka protein tyrosine phosphatase meg)
F: None of the above. | D |
<Instruct>: Given the context 'PTPase MEG cDNA contains an open reading frame of 926 amino acids.', select the correct biomedical concept corresponding to 'ptpase meg'. Answer using one of the provided options. | <Options>: A: protein tyrosine phosphatase meg (drosophila melanogaster) (aka protein tyrosine phosphatase meg)
B: ptp-pest (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 12)
C: ptpmeg1 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
D: ptpmeg (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 4)
E: pgp (mus musculus) (phosphoglycolate phosphatase (mus musculus)) (aka phosphoglycolate phosphatase)
F: None of the above. | C |
<Instruct>: Given the context 'The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein.', select the correct biomedical concept corresponding to 'erythrocyte protein 4.1'. Answer using one of the provided options. | <Options>: A: erythrocyte membrane protein band 4.1 (homo sapiens) (aka erythrocyte membrane protein band 4.1)
B: erythrocyte membrane protein band 4.2 (homo sapiens) (aka erythrocyte membrane protein band 4.2)
C: erythrocyte membrane protein band 4.1 (bos taurus) (aka erythrocyte membrane protein band 4.1)
D: erythrocyte membrane protein band 4.1 like 4a (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 4a)
E: erythrocyte membrane protein band 4.1 like 3 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 3)
F: None of the above. | A |
<Instruct>: Given the context 'The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein.', select the correct biomedical concept corresponding to 'erythrocyte protein 4.1'. Answer using one of the provided options. | <Options>: A: erythrocyte membrane protein band 4.2 (homo sapiens) (aka erythrocyte membrane protein band 4.2)
B: erythrocyte membrane protein band 4.1 like 2 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 2)
C: erythrocyte membrane protein band 4.1 like 1 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 1)
D: erythrocyte membrane protein band 4.1 like 1 (bos taurus) (aka erythrocyte membrane protein band 4.1 like 1)
E: erythrocyte membrane protein band 4.1 like 4b (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 4b)
F: None of the above. | F |
<Instruct>: Given the context 'The receptor for ciliary neurotrophic factor.
', select the correct biomedical concept corresponding to 'receptor for ciliary neurotrophic factor'. Answer using one of the provided options. | <Options>: A: ciliary neurotrophic factor receptor (sus scrofa) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
D: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
E: ciliary neurotrophic factor receptor (mus musculus) (aka ciliary neurotrophic factor receptor)
F: None of the above. | C |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept corresponding to 'receptor for ciliary neurotrophic factor'. Answer using one of the provided options. | <Options>: A: ckr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
B: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: ciliary neurotrophic factor receptor (bos taurus) (aka ciliary neurotrophic factor receptor)
E: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
F: None of the above. | B |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept corresponding to 'cntf'. Answer using one of the provided options. | <Options>: A: cntf (rattus norvegicus) (aka ciliary neurotrophic factor)
B: cntf (bos taurus) (aka ciliary neurotrophic factor)
C: cellular communication network factor 1 (homo sapiens) (aka cellular communication network factor 1)
D: cntn1 (homo sapiens) (aka contactin 1)
E: cntf (homo sapiens) (aka ciliary neurotrophic factor)
F: None of the above. | E |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept corresponding to 'cntf receptor'. Answer using one of the provided options. | <Options>: A: npffr1 (rattus norvegicus) (aka neuropeptide ff receptor 1)
B: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
E: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
F: None of the above. | B |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept corresponding to 'interleukin-6'. Answer using one of the provided options. | <Options>: A: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
C: il7 (homo sapiens) (aka interleukin 7)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | A |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept corresponding to 'cntf receptor'. Answer using one of the provided options. | <Options>: A: cntfr-alpha (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
D: npffr1 (rattus norvegicus) (aka neuropeptide ff receptor 1)
E: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
F: None of the above. | E |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept corresponding to 'interleukin-6 receptor'. Answer using one of the provided options. | <Options>: A: il6st (homo sapiens) (aka interleukin 6 cytokine family signal transducer)
B: il-6ra (homo sapiens) (aka interleukin 6 receptor)
C: il6rl1 (homo sapiens) (aka interleukin 6 receptor pseudogene 1)
D: None of the above. | B |
<Instruct>: Given the context 'In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.', select the correct biomedical concept corresponding to 'cntf receptor'. Answer using one of the provided options. | <Options>: A: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: cntfr-alpha (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
E: ciliary neurotrophic factor receptor (gallus gallus) (aka ciliary neurotrophic factor receptor)
F: None of the above. | A |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept corresponding to 'cellular retinol-binding protein type ii'. Answer using one of the provided options. | <Options>: A: retinol binding protein 2 (xenopus tropicalis) (aka retinol binding protein 2)
B: retinol binding protein 5 (homo sapiens) (aka retinol binding protein 5)
C: retinol binding protein 1 (homo sapiens) (aka retinol binding protein 1)
D: rbp2 (homo sapiens) (retinol binding protein 2 (homo sapiens)) (aka retinol binding protein 2)
E: retinol binding protein 3 (homo sapiens) (aka retinol binding protein 3)
F: None of the above. | D |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept corresponding to 'rxr'. Answer using one of the provided options. | <Options>: A: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
B: rxrbeta (homo sapiens) (aka retinoid x receptor beta)
C: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
D: rxralpha (homo sapiens) (aka retinoid x receptor alpha)
E: rxrg (homo sapiens) (aka retinoid x receptor gamma)
F: None of the above. | D |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept corresponding to 'rxr'. Answer using one of the provided options. | <Options>: A: rxrg (homo sapiens) (aka retinoid x receptor gamma)
B: rxrbeta (homo sapiens) (aka retinoid x receptor beta)
C: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
D: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
E: None of the above. | E |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept corresponding to 'retinoid x receptor'. Answer using one of the provided options. | <Options>: A: retinoid x receptor gamma (homo sapiens) (aka retinoid x receptor gamma)
B: rxralpha (homo sapiens) (aka retinoid x receptor alpha)
C: retinoid x receptor alpha (xenopus tropicalis) (aka retinoid x receptor alpha)
D: lxra (homo sapiens) (aka nuclear receptor subfamily 1 group h member 3)
E: retinoid x receptor beta (homo sapiens) (aka retinoid x receptor beta)
F: None of the above. | B |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept corresponding to 'rxr'. Answer using one of the provided options. | <Options>: A: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
B: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
C: rxrbeta (homo sapiens) (aka retinoid x receptor beta)
D: rxra (homo sapiens) (aka retinoid x receptor alpha)
E: rxrg (homo sapiens) (aka retinoid x receptor gamma)
F: None of the above. | D |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept corresponding to 'cellular retinol-binding protein type ii'. Answer using one of the provided options. | <Options>: A: retinol binding protein 5 (homo sapiens) (aka retinol binding protein 5)
B: retinol binding protein 2 (homo sapiens) (aka retinol binding protein 2)
C: retinol binding protein 7 (homo sapiens) (aka retinol binding protein 7)
D: retinol binding protein 3 (homo sapiens) (aka retinol binding protein 3)
E: retinol binding protein 1 (homo sapiens) (aka retinol binding protein 1)
F: None of the above. | B |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept corresponding to 'crbpii'. Answer using one of the provided options. | <Options>: A: crbpiv (homo sapiens) (aka retinol binding protein 7)
B: crbpiii (homo sapiens) (aka retinol binding protein 5)
C: crbp2 (homo sapiens) (aka retinol binding protein 2)
D: crbpi (homo sapiens) (aka retinol binding protein 1)
E: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
F: None of the above. | C |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept corresponding to 'rxr'. Answer using one of the provided options. | <Options>: A: rxrg (homo sapiens) (aka retinoid x receptor gamma)
B: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
C: rxrb (homo sapiens) (aka retinoid x receptor beta)
D: rxr-alpha (homo sapiens) (aka retinoid x receptor alpha)
E: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
F: None of the above. | D |
<Instruct>: Given the context 'This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide.', select the correct biomedical concept corresponding to 'crbpii'. Answer using one of the provided options. | <Options>: A: crbpii (homo sapiens) (aka retinol binding protein 2)
B: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
C: crbp (homo sapiens) (aka retinol binding protein 1)
D: crbpiii (homo sapiens) (aka retinol binding protein 5)
E: crbpiv (homo sapiens) (aka retinol binding protein 7)
F: None of the above. | A |
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