instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'tx'. Answer using one of the provided options. | <Options>: A: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
B: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
C: tx1 (xenopus tropicalis) (aka mab-21-like 3)
D: tx (homo sapiens) (aka caspase 4)
E: tx (drosophila melanogaster) (aka taxi)
F: None of the above. | D |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'interleukin-1 beta converting enzyme'. Answer using one of the provided options. | <Options>: A: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: casp7 (homo sapiens) (aka caspase 7)
D: casp3 (homo sapiens) (aka caspase 3)
E: caspase 1 (homo sapiens) (aka caspase 1)
F: None of the above. | E |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'ice'. Answer using one of the provided options. | <Options>: A: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
B: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice(rel)ii (homo sapiens) (aka caspase 4)
F: None of the above. | C |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'ice'. Answer using one of the provided options. | <Options>: A: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
B: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: ice(rel)iii (homo sapiens) (aka caspase 5)
E: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
F: None of the above. | A |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'nedd-2'. Answer using one of the provided options. | <Options>: A: death regulator nedd2-like caspase (drosophila melanogaster) (aka death regulator nedd2-like caspase)
B: nedd9 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
C: nedd2 (homo sapiens) (aka caspase 2)
D: nedd7 (homo sapiens) (aka dnaj heat shock protein family (hsp40) member a1)
E: nedd8 (homo sapiens) (aka nedd8 ubiquitin like modifier)
F: None of the above. | C |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept corresponding to 'ich-1l'. Answer using one of the provided options. | <Options>: A: caspase 1 (homo sapiens) (aka caspase 1)
B: ich-1 (mus musculus) (aka caspase 2)
C: casp-8 (homo sapiens) (aka caspase 8)
D: ich1 (homo sapiens) (aka caspase 2)
E: casp7 (homo sapiens) (aka caspase 7)
F: None of the above. | D |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept corresponding to 'tx'. Answer using one of the provided options. | <Options>: A: tx (homo sapiens) (aka caspase 4)
B: txs (homo sapiens) (aka thromboxane a synthase 1)
C: tx1 (xenopus tropicalis) (aka mab-21-like 3)
D: tx (drosophila melanogaster) (aka taxi)
E: txl (homo sapiens) (aka thioredoxin like 1)
F: None of the above. | A |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept corresponding to 'ice'. Answer using one of the provided options. | <Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: ice(rel)iii (homo sapiens) (aka caspase 5)
E: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
F: None of the above. | C |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept corresponding to 'ice'. Answer using one of the provided options. | <Options>: A: ice(rel)ii (homo sapiens) (aka caspase 4)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
D: ich-3 (homo sapiens) (aka caspase 5)
E: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
F: None of the above. | F |
<Instruct>: Given the context 'This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained.', select the correct biomedical concept corresponding to 'tx'. Answer using one of the provided options. | <Options>: A: tx (homo sapiens) (aka caspase 4)
B: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
C: tx (drosophila melanogaster) (aka taxi)
D: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
E: txs (homo sapiens) (aka thromboxane a synthase 1)
F: None of the above. | A |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept corresponding to 'tx'. Answer using one of the provided options. | <Options>: A: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
B: tx (drosophila melanogaster) (aka taxi)
C: txs (homo sapiens) (aka thromboxane a synthase 1)
D: tx (homo sapiens) (aka caspase 4)
E: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept corresponding to 'ice'. Answer using one of the provided options. | <Options>: A: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
B: ice(rel)ii (homo sapiens) (aka caspase 4)
C: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
D: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene)
F: None of the above. | A |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept corresponding to 'il-1 beta'. Answer using one of the provided options. | <Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: il1-beta (homo sapiens) (aka interleukin 1 beta)
D: None of the above. | C |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept corresponding to 'pro-il-1 beta'. Answer using one of the provided options. | <Options>: A: il1-beta (homo sapiens) (aka interleukin 1 beta)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: il-1h (homo sapiens) (aka interleukin 37)
D: il-1a (homo sapiens) (aka interleukin 1 alpha)
E: None of the above. | A |
<Instruct>: Given the context 'TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death.', select the correct biomedical concept corresponding to 'tx'. Answer using one of the provided options. | <Options>: A: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
B: txs (homo sapiens) (aka thromboxane a synthase 1)
C: tx (homo sapiens) (aka caspase 4)
D: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
E: txl (homo sapiens) (aka thioredoxin like 1)
F: None of the above. | C |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
B: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | E |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept corresponding to 'ly-6 antigen thb'. Answer using one of the provided options. | <Options>: A: integrin subunit beta 6 (homo sapiens) (aka integrin subunit beta 6)
B: cd6 molecule (homo sapiens) (aka cd6 molecule)
C: tnf receptor superfamily member 6b (homo sapiens) (aka tnf receptor superfamily member 6b)
D: lymphocyte antigen 6 family member k (homo sapiens) (aka lymphocyte antigen 6 family member k)
E: thy-1 cell surface antigen (homo sapiens) (aka thy-1 cell surface antigen)
F: None of the above. | F |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
E: es18 (homo sapiens) (aka programmed cell death 7)
F: None of the above. | C |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept corresponding to 'desmoglein iii'. Answer using one of the provided options. | <Options>: A: desmoglein 3 (bos taurus) (aka desmoglein 3)
B: desmoglein 3 (mus musculus) (aka desmoglein 3)
C: desmoglein 2 (homo sapiens) (aka desmoglein 2)
D: desmoglein 3 (homo sapiens) (aka desmoglein 3)
E: desmoglein 4 (homo sapiens) (aka desmoglein 4)
F: None of the above. | D |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept corresponding to 'desmoglein iii'. Answer using one of the provided options. | <Options>: A: desmoglein 3 (sus scrofa) (aka desmoglein 3)
B: desmoglein 1 (homo sapiens) (aka desmoglein 1)
C: desmoglein 4 (homo sapiens) (aka desmoglein 4)
D: desmoglein 3 (bos taurus) (aka desmoglein 3)
E: desmocollin 3 (homo sapiens) (aka desmocollin 3)
F: None of the above. | F |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept corresponding to 'dg4'. Answer using one of the provided options. | <Options>: A: cdgs4 (homo sapiens) (aka alg3 alpha-1,3- mannosyltransferase)
B: mddga4 (homo sapiens) (aka fukutin)
C: dg6 (homo sapiens) (aka progesterone receptor membrane component 2)
D: dgs-h (homo sapiens) (aka ess-2 spliceosome associated protein)
E: dgk-4 (caenorhabditis elegans) (aka diacylglycerol kinase)
F: None of the above. | F |
<Instruct>: Given the context 'A cDNA clone encoding the E48 antigen was isolated by expression cloning in COS cells.', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: el18 (homo sapiens) (aka ribosomal protein l18)
D: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
E: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
F: None of the above. | B |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
B: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
C: el18 (homo sapiens) (aka ribosomal protein l18)
D: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
F: None of the above. | D |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', select the correct biomedical concept corresponding to 'thb'. Answer using one of the provided options. | <Options>: A: thbgb (homo sapiens) (aka pro-platelet basic protein)
B: t cell receptor beta locus (homo sapiens) (aka t cell receptor beta locus)
C: thbs (bos taurus) (aka thrombospondin 1)
D: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
E: thbs (homo sapiens) (aka thrombospondin 1)
F: None of the above. | D |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept corresponding to 'phosphatidylinositol-specific (pi-specific) phospholipase-c'. Answer using one of the provided options. | <Options>: A: phosphatidylinositol phospholipase c (candida albicans sc5314) (aka phosphatidylinositol phospholipase c)
B: plc-iv (homo sapiens) (aka phospholipase c gamma 2)
C: plc-iii (homo sapiens) (aka phospholipase c delta 1)
D: plc-l3 (homo sapiens) (aka phospholipase c eta 1)
E: plc-ii (homo sapiens) (aka phospholipase c gamma 1)
F: None of the above. | E |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: e47 (homo sapiens) (aka transcription factor 3)
D: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
F: None of the above. | D |
<Instruct>: Given the context 'The gene encoding the E48 antigen is a single copy gene, located on human chromosome 8 in the 8q24-qter region.', select the correct biomedical concept corresponding to 'e48 antigen'. Answer using one of the provided options. | <Options>: A: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
B: es18 (homo sapiens) (aka programmed cell death 7)
C: e47 (homo sapiens) (aka transcription factor 3)
D: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | E |
<Instruct>: Given the context 'The putative mouse homologue, the ThB antigen, originally identified as an antigen on cells of the lymphocyte lineage, was shown to be highly expressed in squamous mouse epithelia.', select the correct biomedical concept corresponding to 'thb'. Answer using one of the provided options. | <Options>: A: thbs (bos taurus) (aka thrombospondin 1)
B: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
C: thbd (bos taurus) (aka thrombomodulin)
D: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
E: thbgb (homo sapiens) (aka pro-platelet basic protein)
F: None of the above. | D |
<Instruct>: Given the context 'Moreover, the ThB expression level is in keratinocytes, in contrast to that in lymphocytes, not mouse strain related.', select the correct biomedical concept corresponding to 'thb'. Answer using one of the provided options. | <Options>: A: t cell receptor beta locus (homo sapiens) (aka t cell receptor beta locus)
B: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
C: thbd (bos taurus) (aka thrombomodulin)
D: thbgb (homo sapiens) (aka pro-platelet basic protein)
E: htnb (homo sapiens) (aka phosphodiesterase 3a)
F: None of the above. | B |
<Instruct>: Given the context 'Transfection of mouse SV40-polyoma transformed mouse NIH/3T3 cells with the E48 cDNA confirmed that the antigen is likely to be involved in cell-cell adhesion.', select the correct biomedical concept corresponding to 'e48'. Answer using one of the provided options. | <Options>: A: basic helix-loop-helix family member e41 (homo sapiens) (aka basic helix-loop-helix family member e41)
B: e4f1 (homo sapiens) (aka e4f transcription factor 1)
C: e47 (homo sapiens) (aka transcription factor 3)
D: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
F: None of the above. | D |
<Instruct>: Given the context 'Transfection of mouse SV40-polyoma transformed mouse NIH/3T3 cells with the E48 cDNA confirmed that the antigen is likely to be involved in cell-cell adhesion.', select the correct biomedical concept corresponding to 'e48'. Answer using one of the provided options. | <Options>: A: basic helix-loop-helix family member e41 (homo sapiens) (aka basic helix-loop-helix family member e41)
B: e46l (homo sapiens) (aka ataxin 10)
C: e4f (homo sapiens) (aka e4f transcription factor 1)
D: e47 (homo sapiens) (aka transcription factor 3)
E: nf-e4 (homo sapiens) (aka nuclear factor, erythroid 4)
F: None of the above. | F |
<Instruct>: Given the context 'Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
', select the correct biomedical concept corresponding to 'peroxisomal targeting signal-1 receptor'. Answer using one of the provided options. | <Options>: A: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
B: peroxisomal biogenesis factor 1 (xenopus tropicalis) (aka peroxisomal biogenesis factor 1)
C: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
D: peroxisomal abc transporter 1 (arabidopsis thaliana) (aka peroxisomal abc transporter 1)
E: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: None of the above. | E |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: None of the above. | E |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept corresponding to 'pas8'. Answer using one of the provided options. | <Options>: A: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
B: pas-3 (homo sapiens) (aka glycophorin b (mns blood group))
C: pasd8 (homo sapiens) (aka hypoxia inducible factor 1 subunit alpha)
D: pas8 (mus musculus) (aka pulmonary adenoma susceptibility 8)
E: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
F: None of the above. | A |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept corresponding to 'pts1 receptor'. Answer using one of the provided options. | <Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pex5r (xenopus tropicalis) (aka peroxisomal biogenesis factor 5-like)
D: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
E: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: None of the above. | E |
<Instruct>: Given the context 'The PTS1R mRNA is expressed in all human tissues examined.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
B: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
C: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pts1 (glycine max) (aka pterocarpan synthase)
F: None of the above. | C |
<Instruct>: Given the context 'Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
D: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
E: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
F: None of the above. | A |
<Instruct>: Given the context 'Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
C: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
D: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | C |
<Instruct>: Given the context 'Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
B: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | A |
<Instruct>: Given the context 'In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts1 (glycine max) (aka pterocarpan synthase)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | D |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept corresponding to 'pas8'. Answer using one of the provided options. | <Options>: A: pas8 (mus musculus) (aka pulmonary adenoma susceptibility 8)
B: bhlha8 (homo sapiens) (aka neurogenin 2)
C: pasd5 (homo sapiens) (aka neuronal pas domain protein 1)
D: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
E: pasd8 (homo sapiens) (aka hypoxia inducible factor 1 subunit alpha)
F: None of the above. | D |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept corresponding to 'pas8'. Answer using one of the provided options. | <Options>: A: pasd6 (homo sapiens) (aka neuronal pas domain protein 3)
B: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
C: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
D: pasp (homo sapiens) (aka carboxypeptidase b1)
E: pas-3 (homo sapiens) (aka glycophorin b (mns blood group))
F: None of the above. | F |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
D: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
E: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept corresponding to 'pas8'. Answer using one of the provided options. | <Options>: A: pasd6 (homo sapiens) (aka neuronal pas domain protein 3)
B: bhlha8 (homo sapiens) (aka neurogenin 2)
C: pasp (homo sapiens) (aka carboxypeptidase b1)
D: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
E: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
F: None of the above. | E |
<Instruct>: Given the context 'The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
B: pts1 (glycine max) (aka pterocarpan synthase)
C: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
F: None of the above. | C |
<Instruct>: Given the context 'The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map.', select the correct biomedical concept corresponding to 'pts1r'. Answer using one of the provided options. | <Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
D: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | B |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
E: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
F: None of the above. | E |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept corresponding to 'ntrk3'. Answer using one of the provided options. | <Options>: A: ntrk3 (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
B: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
C: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
D: ntrk4 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 1)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
F: None of the above. | C |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
B: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
C: ntrk3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
D: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
F: None of the above. | C |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept corresponding to 'neurotrophin-3'. Answer using one of the provided options. | <Options>: A: ntn3 (homo sapiens) (aka netrin 3)
B: ntf3 (xenopus laevis) (neurotrophin 3 l homeolog (xenopus laevis)) (aka neurotrophin 3 l homeolog)
C: ntf3 (xenopus laevis) (neurotrophin 3 s homeolog (xenopus laevis)) (aka neurotrophin 3 s homeolog)
D: ntf3 (homo sapiens) (aka neurotrophin 3)
E: neurotrophin 3 (xenopus tropicalis) (aka neurotrophin 3)
F: None of the above. | D |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
B: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
E: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: None of the above. | D |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
B: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
C: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
D: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
E: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: None of the above. | C |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
E: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: None of the above. | F |
<Instruct>: Given the context 'The rat trkC has several isoforms due to alternative splicing in the tyrosine kinase domain.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
B: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
C: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
E: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
F: None of the above. | E |
<Instruct>: Given the context 'The human trkC cDNA also has a (CGG)n repeat in the 5'-untranslated region.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
F: None of the above. | D |
<Instruct>: Given the context 'By PCR analysis of a somatic cell hybrid panel and fluorescence in situ hybridization with the cDNA clone, human trkC was mapped to chromosome 15q24-q25.', select the correct biomedical concept corresponding to 'trkc'. Answer using one of the provided options. | <Options>: A: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
B: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
C: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
E: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: None of the above. | B |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibulin 1 (homo sapiens) (aka fibulin 1)
B: fibulin 2 (homo sapiens) (aka fibulin 2)
C: fibrillin 2 (homo sapiens) (aka fibrillin 2)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
F: None of the above. | B |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept corresponding to 'fbln2'. Answer using one of the provided options. | <Options>: A: fibulin 2 (homo sapiens) (aka fibulin 2)
B: fbln1 (homo sapiens) (aka fibulin 1)
C: fbln2 (bos taurus) (aka fibulin 2)
D: fbln3 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
E: fbln2 (sus scrofa) (aka fibulin 2)
F: None of the above. | A |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibulin 5 (homo sapiens) (aka fibulin 5)
B: fibulin 2 (homo sapiens) (aka fibulin 2)
C: fibrillin 2 (homo sapiens) (aka fibrillin 2)
D: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
E: fibulin 1 (homo sapiens) (aka fibulin 1)
F: None of the above. | B |
<Instruct>: Given the context 'Fibulin-2 mRNA is prominently expressed in mouse heart tissue and is present in low amounts in other tissues.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibulin 1 (homo sapiens) (aka fibulin 1)
B: fbln2 (homo sapiens) (aka fibulin 2)
C: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
D: fibin (homo sapiens) (aka fin bud initiation factor homolog)
E: fibulin 2 (sus scrofa) (aka fibulin 2)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we isolated and sequenced a 4.1-kb human fibulin-2 cDNA, which encoded a mature protein of 1157 amino acids preceded by a 27-residue signal sequence.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: fibrillin 2 (homo sapiens) (aka fibrillin 2)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: fibulin 5 (homo sapiens) (aka fibulin 5)
F: None of the above. | D |
<Instruct>: Given the context 'The 115-residue C-terminal segment (domain III) is similar to the C variant of fibulin-1.', select the correct biomedical concept corresponding to 'fibulin-1'. Answer using one of the provided options. | <Options>: A: fibl1 (homo sapiens) (aka fibulin 1)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
D: fibrillin 1 (homo sapiens) (aka fibrillin 1)
E: fibin (homo sapiens) (aka fin bud initiation factor homolog)
F: None of the above. | A |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibin (homo sapiens) (aka fin bud initiation factor homolog)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: fibulin 2 (sus scrofa) (aka fibulin 2)
F: None of the above. | D |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibin (homo sapiens) (aka fin bud initiation factor homolog)
B: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
C: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
D: fibrillin 2 (homo sapiens) (aka fibrillin 2)
E: fibulin 1 (homo sapiens) (aka fibulin 1)
F: None of the above. | F |
<Instruct>: Given the context 'The expression pattern differs from that of fibulin-1.', select the correct biomedical concept corresponding to 'fibulin-1'. Answer using one of the provided options. | <Options>: A: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
B: fibulin 2 (homo sapiens) (aka fibulin 2)
C: fibrillin 1 (homo sapiens) (aka fibrillin 1)
D: fibl1 (homo sapiens) (aka fibulin 1)
E: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
F: None of the above. | D |
<Instruct>: Given the context 'The fibulin-2 gene was localized by in situ hybridization to the p24-p25 region of human chromosome 3 and to the band D-E of mouse chromosome 6.', select the correct biomedical concept corresponding to 'fibulin-2'. Answer using one of the provided options. | <Options>: A: fibulin 2 (sus scrofa) (aka fibulin 2)
B: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
C: fibrillin 2 (homo sapiens) (aka fibrillin 2)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
F: None of the above. | D |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept corresponding to 'tata-binding protein'. Answer using one of the provided options. | <Options>: A: tata-box binding protein like 1 (bos taurus) (aka tata-box binding protein like 1)
B: tfiid (xenopus tropicalis) (tata-box binding protein (xenopus tropicalis)) (aka tata-box binding protein)
C: tata-box binding protein like 1 (xenopus tropicalis) (aka tata-box binding protein like 1)
D: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
E: tata-binding protein (saccharomyces cerevisiae s288c) (aka tata-binding protein)
F: None of the above. | D |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept corresponding to 'tbp'. Answer using one of the provided options. | <Options>: A: tbp (xenopus tropicalis) (tata-box binding protein (xenopus tropicalis)) (aka tata-box binding protein)
B: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
C: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
D: tbpa (homo sapiens) (aka transthyretin)
E: tbp (bos taurus) (aka tata-box binding protein)
F: None of the above. | C |
<Instruct>: Given the context 'The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described.', select the correct biomedical concept corresponding to 'tafii55'. Answer using one of the provided options. | <Options>: A: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
B: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
C: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
D: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
E: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)
F: None of the above. | C |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'tafii55'. Answer using one of the provided options. | <Options>: A: taf5 (saccharomyces cerevisiae s288c) (aka chromatin modification protein)
B: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
C: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
D: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
E: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
F: None of the above. | D |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'tafii230'. Answer using one of the provided options. | <Options>: A: tafii-250 (homo sapiens) (aka tata-box binding protein associated factor 1)
B: taf30 (saccharomyces cerevisiae s288c) (aka tata-binding protein-associated factor taf14)
C: taf25 (saccharomyces cerevisiae s288c) (aka taf10p)
D: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 1 (drosophila melanogaster)) (aka tbp-associated factor 1)
E: taf3 (saccharomyces cerevisiae s288c) (aka taf3p)
F: None of the above. | A |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'sp1'. Answer using one of the provided options. | <Options>: A: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
B: sp1 (xenopus tropicalis) (sp1 transcription factor (xenopus tropicalis)) (aka sp1 transcription factor)
C: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
D: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
E: h-sp1 (homo sapiens) (aka synaptophysin like 1)
F: None of the above. | D |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'yy1'. Answer using one of the provided options. | <Options>: A: yy1 transcription factor (xenopus tropicalis) (aka yy1 transcription factor)
B: yy1 transcription factor (homo sapiens) (aka yy1 transcription factor)
C: yy1 (xenopus laevis) (yy1 transcription factor l homeolog (xenopus laevis)) (aka yy1 transcription factor l homeolog)
D: yy1 (drosophila melanogaster) (aka pleiohomeotic)
E: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
F: None of the above. | B |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'usf'. Answer using one of the provided options. | <Options>: A: ush1f (homo sapiens) (aka protocadherin related 15)
B: usf1 (xenopus tropicalis) (aka upstream transcription factor 1)
C: usf1 (homo sapiens) (aka upstream transcription factor 1)
D: protein usf-like (glycine max) (aka protein usf-like)
E: usf3 (homo sapiens) (aka upstream transcription factor family member 3)
F: None of the above. | C |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept corresponding to 'usf'. Answer using one of the provided options. | <Options>: A: usf1p (homo sapiens) (aka upstream transcription factor 1 pseudogene 1)
B: ush1f (homo sapiens) (aka protocadherin related 15)
C: usf3 (homo sapiens) (aka upstream transcription factor family member 3)
D: usf1 (xenopus tropicalis) (aka upstream transcription factor 1)
E: usf (drosophila melanogaster) (aka usf)
F: None of the above. | F |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept corresponding to 'tafii55'. Answer using one of the provided options. | <Options>: A: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
B: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
C: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
D: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)
E: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
F: None of the above. | A |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept corresponding to 'sp1'. Answer using one of the provided options. | <Options>: A: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
B: sp1 transcription factor (xenopus tropicalis) (aka sp1 transcription factor)
C: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
D: sp1 (mus musculus) (aka trans-acting transcription factor 1)
E: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
F: None of the above. | A |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept corresponding to 'tafii110'. Answer using one of the provided options. | <Options>: A: tafii100 (homo sapiens) (aka tata-box binding protein associated factor 5)
B: tafii130 (homo sapiens) (aka tata-box binding protein associated factor 4)
C: tafii70 (homo sapiens) (aka tata-box binding protein associated factor 6)
D: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
E: tafii140 (homo sapiens) (aka tata-box binding protein associated factor 3)
F: None of the above. | F |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept corresponding to 'ergic-53'. Answer using one of the provided options. | <Options>: A: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
B: ergic-53l (mus musculus) (aka complexin 3)
C: ergic3 (homo sapiens) (aka ergic and golgi 3)
D: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
E: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
F: None of the above. | D |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
B: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
C: mr60 (homo sapiens) (aka lectin, mannose binding 1)
D: hel60 (homo sapiens) (aka aconitase 1)
E: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
F: None of the above. | C |
<Instruct>: Given the context 'A mannose-specific membrane lectin (MR60) isolated from human myelomonocytic HL60 cells by affinity chromatography is expressed in intracellular organelles of immature monocytes (Pimpaneau, V., Midoux, P., Monsigny, M., and Roche, A. C. (1991) Carbohydr.', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: hel60 (homo sapiens) (aka aconitase 1)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
D: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
E: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
F: None of the above. | B |
<Instruct>: Given the context 'It is not present at the cell surface and is immunochemically and structurally distinct from the M(r) 175,000 mannose receptor of mature macrophages.', select the correct biomedical concept corresponding to 'm(r) 175,000 mannose receptor of mature macrophages'. Answer using one of the provided options. | <Options>: A: mannose receptor, c type 2 (mus musculus) (aka mannose receptor, c type 2)
B: mannose receptor c-type 1 (homo sapiens) (aka mannose receptor c-type 1)
C: mr (mus musculus) (mannose receptor, c type 1 (mus musculus)) (aka mannose receptor, c type 1)
D: mannose receptor c-type 2 (homo sapiens) (aka mannose receptor c-type 2)
E: macrophage receptor with collagenous structure (mus musculus) (aka macrophage receptor with collagenous structure)
F: None of the above. | B |
<Instruct>: Given the context 'MR60 cDNA was isolated and characterized; on the basis of its sequence, MR60 is not related to any known mammalian lectins.', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
C: mr60 (homo sapiens) (aka lectin, mannose binding 1)
D: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
E: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
F: None of the above. | C |
<Instruct>: Given the context 'MR60 cDNA was isolated and characterized; on the basis of its sequence, MR60 is not related to any known mammalian lectins.', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: hel60 (homo sapiens) (aka aconitase 1)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
D: ro60 (homo sapiens) (aka ro60, y rna binding protein)
E: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
F: None of the above. | B |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
D: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
E: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | B |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
B: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
C: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
D: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
E: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
F: None of the above. | F |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept corresponding to 'ergic-53'. Answer using one of the provided options. | <Options>: A: ergic3 (homo sapiens) (aka ergic and golgi 3)
B: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
C: ergic-53l (mus musculus) (aka complexin 3)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
E: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
F: None of the above. | B |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
B: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
C: mr60 (homo sapiens) (aka lectin, mannose binding 1)
D: ro60 (homo sapiens) (aka ro60, y rna binding protein)
E: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
F: None of the above. | C |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept corresponding to 'ergic-53'. Answer using one of the provided options. | <Options>: A: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
B: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
C: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
D: ergic-53l (mus musculus) (aka complexin 3)
E: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
F: None of the above. | C |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept corresponding to 'vip-36'. Answer using one of the provided options. | <Options>: A: vip36 (mus musculus) (aka lectin, mannose-binding 2)
B: vip36 (homo sapiens) (aka lectin, mannose binding 2)
C: vip36-like (mus musculus) (aka lectin, mannose-binding 2-like)
D: vip32 (homo sapiens) (aka arginine vasopressin induced 1)
E: vip36 (rattus norvegicus) (aka lectin, mannose-binding 2)
F: None of the above. | B |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
B: ro60 (homo sapiens) (aka ro60, y rna binding protein)
C: mr60 (homo sapiens) (aka lectin, mannose binding 1)
D: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
E: hel60 (homo sapiens) (aka aconitase 1)
F: None of the above. | C |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept corresponding to 'ergic-53'. Answer using one of the provided options. | <Options>: A: ergic53 (drosophila melanogaster) (aka ergic53)
B: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
C: ergic-53 (homo sapiens) (aka lectin, mannose binding 1)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
E: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
F: None of the above. | C |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept corresponding to 'mr60'. Answer using one of the provided options. | <Options>: A: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
B: ro60 (homo sapiens) (aka ro60, y rna binding protein)
C: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
D: mr60 (homo sapiens) (aka lectin, mannose binding 1)
E: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
F: None of the above. | D |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept corresponding to 'ergic-53'. Answer using one of the provided options. | <Options>: A: ergic3 (homo sapiens) (aka ergic and golgi 3)
B: ergic53 (drosophila melanogaster) (aka ergic53)
C: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
E: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
F: None of the above. | E |
<Instruct>: Given the context 'Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
', select the correct biomedical concept corresponding to 'type 1 tumor necrosis factor receptor'. Answer using one of the provided options. | <Options>: A: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: tnfrsf1a (homo sapiens) (aka tnf receptor superfamily member 1a)
E: None of the above. | D |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept corresponding to 'type 1 receptor for tumor necrosis factor'. Answer using one of the provided options. | <Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
E: None of the above. | C |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept corresponding to 'type 1 receptor for tumor necrosis factor'. Answer using one of the provided options. | <Options>: A: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
B: tnf receptor superfamily member 1b (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
D: None of the above. | D |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept corresponding to 'tnfr-1ic'. Answer using one of the provided options. | <Options>: A: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
B: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
E: None of the above. | C |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept corresponding to 'tnf receptor-associated protein'. Answer using one of the provided options. | <Options>: A: trap1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
B: tnf receptor-associated protein 1 (xenopus tropicalis) (aka tnf receptor-associated protein 1)
C: tnf receptor associated factor 6 (homo sapiens) (aka tnf receptor associated factor 6)
D: tnf receptor associated factor 5 (homo sapiens) (aka tnf receptor associated factor 5)
E: tnf receptor associated protein 1 (bos taurus) (aka tnf receptor associated protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
B: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
C: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
D: trap95 (homo sapiens) (aka mediator complex subunit 16)
E: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
F: None of the above. | F |
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