instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trap95 (homo sapiens) (aka mediator complex subunit 16)
B: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
C: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
D: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
E: trap100 (homo sapiens) (aka mediator complex subunit 24)
F: None of the above. | F |
<Instruct>: Given the context 'After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact.', select the correct biomedical concept corresponding to 'tnfr-1ic'. Answer using one of the provided options. | <Options>: A: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
E: None of the above. | D |
<Instruct>: Given the context 'The ability of deletion mutants of TNFR-1 to interact with TRAP-1 was tested using the two hybrid system.', select the correct biomedical concept corresponding to 'tnfr-1'. Answer using one of the provided options. | <Options>: A: tnfr1 (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: None of the above. | A |
<Instruct>: Given the context 'The ability of deletion mutants of TNFR-1 to interact with TRAP-1 was tested using the two hybrid system.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
B: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
D: trap100 (homo sapiens) (aka mediator complex subunit 24)
E: trap95 (homo sapiens) (aka mediator complex subunit 16)
F: None of the above. | F |
<Instruct>: Given the context 'This showed that the amino acid sequences that mediate binding are diffusely distributed outside of the domain in the C terminus of TNFR-1IC that signals cytotoxicity.', select the correct biomedical concept corresponding to 'tnfr-1ic'. Answer using one of the provided options. | <Options>: A: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
B: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
E: None of the above. | D |
<Instruct>: Given the context 'The 2.4-kilobase TRAP-1 mRNA was variably expressed in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, and placenta.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: tnf receptor associated protein 1 (homo sapiens) (aka tnf receptor associated protein 1)
B: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
D: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
E: trap95 (homo sapiens) (aka mediator complex subunit 16)
F: None of the above. | F |
<Instruct>: Given the context 'TRAP-1 mRNA was also detected in each of eight different transformed cell lines.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
B: trap1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
D: trap95 (homo sapiens) (aka mediator complex subunit 16)
E: trap100 (homo sapiens) (aka mediator complex subunit 24)
F: None of the above. | F |
<Instruct>: Given the context 'TRAP-1 mRNA was also detected in each of eight different transformed cell lines.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
B: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
C: trap100 (homo sapiens) (aka mediator complex subunit 24)
D: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
E: trap1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'Identification of TRAP-1 may be an important step toward defining how TNFR-1, which does not contain protein tyrosine kinase activity, transmits its message to signal transduction pathways.', select the correct biomedical concept corresponding to 'trap-1'. Answer using one of the provided options. | <Options>: A: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
B: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
C: trap95 (homo sapiens) (aka mediator complex subunit 16)
D: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
E: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
F: None of the above. | F |
<Instruct>: Given the context 'Identification of TRAP-1 may be an important step toward defining how TNFR-1, which does not contain protein tyrosine kinase activity, transmits its message to signal transduction pathways.', select the correct biomedical concept corresponding to 'tnfr-1'. Answer using one of the provided options. | <Options>: A: tnf receptor superfamily member 1b (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfrsf1a (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
D: None of the above. | B |
<Instruct>: Given the context 'Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase.', select the correct biomedical concept corresponding to 'stomach alcohol dehydrogenase'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 6 (class v) (homo sapiens) (aka alcohol dehydrogenase 6 (class v))
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
D: adh7 (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
E: alcohol dehydrogenase 6 (class v) (rattus norvegicus) (aka alcohol dehydrogenase 6 (class v))
F: None of the above. | D |
<Instruct>: Given the context 'A full-length 1966-base pair clone of the human class IV alcohol dehydrogenase (sigma-ADH) was isolated from a human stomach cDNA library.', select the correct biomedical concept corresponding to 'class iv alcohol dehydrogenase'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 4 (class ii), pi polypeptide (homo sapiens) (aka alcohol dehydrogenase 4 (class ii), pi polypeptide)
B: alcohol dehydrogenase 4 (class ii), pi polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 4 (class ii), pi polypeptide)
C: alcohol dehydrogenase adh4 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh4)
D: alcohol dehydrogenase 6a (class v) (rattus norvegicus) (aka alcohol dehydrogenase 6a (class v))
E: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
F: None of the above. | E |
<Instruct>: Given the context 'A full-length 1966-base pair clone of the human class IV alcohol dehydrogenase (sigma-ADH) was isolated from a human stomach cDNA library.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
C: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
E: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
F: None of the above. | A |
<Instruct>: Given the context 'The 373-amino acid sigma-ADH encoded by this cDNA was expressed in Escherichia coli.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
D: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
E: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
F: None of the above. | D |
<Instruct>: Given the context 'Kinetic analysis of the catalytic efficiency (kcat/KM) of recombinant sigma-ADH for oxidation of primary alcohols indicated broad substrate specificity.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
C: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
D: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
E: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
F: None of the above. | A |
<Instruct>: Given the context 'Recombinant human sigma-ADH exhibited high catalytic efficiency for oxidation of all-trans-retinol to all-trans-retinal.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
B: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
C: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
E: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
F: None of the above. | C |
<Instruct>: Given the context 'Secondary alcohols and 3 beta-hydroxysteroids were inactive with sigma-ADH or were oxidized with very low efficiency.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
E: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
F: None of the above. | C |
<Instruct>: Given the context 'The KM of sigma-ADH for ethanol was 25 mM, and the KM for primary straight chain alcohols decreased substantially as chain length increased.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
C: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
E: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
F: None of the above. | A |
<Instruct>: Given the context 'The KM of sigma-ADH for ethanol was 25 mM, and the KM for primary straight chain alcohols decreased substantially as chain length increased.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
B: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
C: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
E: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
F: None of the above. | F |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency for secondary alcohols of sigma-ADH relative to beta 1-ADH.', select the correct biomedical concept corresponding to 'class iv (sigma)'. Answer using one of the provided options. | <Options>: A: sigma5 (mus musculus) (aka adaptor-related protein 5 complex, sigma 1 subunit)
B: sigma3a (homo sapiens) (aka adaptor related protein complex 3 subunit sigma 1)
C: sigma1a (homo sapiens) (aka adaptor related protein complex 1 subunit sigma 1)
D: sigma1c (homo sapiens) (aka adaptor related protein complex 1 subunit sigma 3)
E: sigma1r (homo sapiens) (aka sigma non-opioid intracellular receptor 1)
F: None of the above. | F |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency for secondary alcohols of sigma-ADH relative to beta 1-ADH.', select the correct biomedical concept corresponding to 'class i (beta) alcohol dehydrogenases'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: adh1b (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
C: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
D: alcohol dehydrogenase 4 (class ii), pi polypeptide (homo sapiens) (aka alcohol dehydrogenase 4 (class ii), pi polypeptide)
E: alcohol dehydrogenase 1b (class i), beta polypeptide (bos taurus) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
F: None of the above. | B |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency for secondary alcohols of sigma-ADH relative to beta 1-ADH.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
C: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
D: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
E: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
F: None of the above. | A |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency for secondary alcohols of sigma-ADH relative to beta 1-ADH.', select the correct biomedical concept corresponding to 'beta 1-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 1b (class i), beta polypeptide (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
B: adh1c (homo sapiens) (aka alcohol dehydrogenase 1c (class i), gamma polypeptide)
C: adh1b promoter (homo sapiens) (aka adh1b promoter)
D: alcohol dehydrogenase 1b (class i), beta polypeptide (bos taurus) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
E: alcohol dehydrogenase 1b (class i), beta polypeptide (xenopus tropicalis) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
F: None of the above. | A |
<Instruct>: Given the context 'For example, modeling the binding of all-trans-retinol in the human beta 1-ADH structure suggested that coordination of retinol to the active-site zinc is hindered by a loop from residues 114 to 120 that is at the entrance to the alcohol-binding site.', select the correct biomedical concept corresponding to 'beta 1-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 1b (class i), beta polypeptide (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
B: adh1c (homo sapiens) (aka alcohol dehydrogenase 1c (class i), gamma polypeptide)
C: adh1b promoter (homo sapiens) (aka adh1b promoter)
D: alcohol dehydrogenase 1b (class i), beta polypeptide (xenopus tropicalis) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
E: alcohol dehydrogenase 1b (class i), beta polypeptide (bos taurus) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
F: None of the above. | A |
<Instruct>: Given the context 'The deletion of Gly-117 in human sigma-ADH and a substitution of Leu for the bulky Tyr-110 appear to facilitate retinol access to the active-site zinc.', select the correct biomedical concept corresponding to 'sigma-adh'. Answer using one of the provided options. | <Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
D: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
E: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
F: None of the above. | B |
<Instruct>: Given the context 'The first 240 nucleotides in the 5' untranslated region of type I acetyl-CoA-carboxylase mRNA replace the first 100 nucleotides of the (G + C)-rich region of the 5' untranslated region of the type II mRNA.', select the correct biomedical concept corresponding to 'type i acetyl-coa-carboxylase'. Answer using one of the provided options. | <Options>: A: propionyl-coa carboxylase subunit alpha (homo sapiens) (aka propionyl-coa carboxylase subunit alpha)
B: methylcrotonyl-coa carboxylase subunit 1 (homo sapiens) (aka methylcrotonyl-coa carboxylase subunit 1)
C: acetyl-coa carboxylase alpha (homo sapiens) (aka acetyl-coa carboxylase alpha)
D: acetyl-coa carboxylase beta (homo sapiens) (aka acetyl-coa carboxylase beta)
E: acc-1 (homo sapiens) (aka bcl2 related protein a1)
F: None of the above. | C |
<Instruct>: Given the context 'Human mu opiate receptor.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opr (mus musculus) (aka zinc finger protein of the cerebellum 5)
B: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: opioid receptor-like 1 (mus musculus) (aka opioid receptor-like 1)
D: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
E: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
F: None of the above. | D |
<Instruct>: Given the context 'A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
C: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
D: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
E: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
F: None of the above. | B |
<Instruct>: Given the context 'A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opr (mus musculus) (aka zinc finger protein of the cerebellum 5)
B: opioid receptor, mu 1 (rattus norvegicus) (aka opioid receptor, mu 1)
C: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
D: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
E: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
F: None of the above. | C |
<Instruct>: Given the context 'A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
B: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
C: oprm1 (mus musculus) (aka opioid receptor, mu 1)
D: opr (mus musculus) (aka zinc finger protein of the cerebellum 5)
E: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
F: None of the above. | F |
<Instruct>: Given the context 'The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opioid receptor, mu 1 (rattus norvegicus) (aka opioid receptor, mu 1)
B: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
C: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
D: nop (mus musculus) (opioid receptor-like 1 (mus musculus)) (aka opioid receptor-like 1)
E: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
F: None of the above. | E |
<Instruct>: Given the context 'The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence.', select the correct biomedical concept corresponding to 'h mu or1'. Answer using one of the provided options. | <Options>: A: m-or-1 (mus musculus) (aka opioid receptor, mu 1)
B: or-1 (mus musculus) (aka nuclear receptor subfamily 1, group h, member 2)
C: m-or-1 (homo sapiens) (aka opioid receptor mu 1)
D: or1m1 (homo sapiens) (aka olfactory receptor family 1 subfamily m member 1)
E: or1n1 (mus musculus) (aka olfactory receptor family 1 subfamily n member 1)
F: None of the above. | C |
<Instruct>: Given the context 'The expressed mu OR1 recognized tested opiate drugs and opioid peptides in a sodium- and GTP-sensitive fashion with affinities virtually identical to those displayed by the rat mu opiate receptor.', select the correct biomedical concept corresponding to 'mu or1'. Answer using one of the provided options. | <Options>: A: or1r1 (mus musculus) (aka olfactory receptor family 1 subfamily jrmember 1)
B: olfactory receptor family 1 subfamily o member 1 (mus musculus) (aka olfactory receptor family 1 subfamily o member 1)
C: or1af1 (mus musculus) (aka olfactory receptor family 1 subfamily af member 1)
D: or-1 (mus musculus) (aka nuclear receptor subfamily 1, group h, member 2)
E: or1a1 (mus musculus) (aka olfactory receptor family 1 subfamily a member 1)
F: None of the above. | F |
<Instruct>: Given the context 'The expressed mu OR1 recognized tested opiate drugs and opioid peptides in a sodium- and GTP-sensitive fashion with affinities virtually identical to those displayed by the rat mu opiate receptor.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
B: oprm1 (mus musculus) (aka opioid receptor, mu 1)
C: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
D: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: opioid receptor-like 1 (mus musculus) (aka opioid receptor-like 1)
F: None of the above. | D |
<Instruct>: Given the context 'Effects on cyclic AMP are similar to those noted for the rat mu opiate receptor.', select the correct biomedical concept corresponding to 'mu opiate receptor'. Answer using one of the provided options. | <Options>: A: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: opioid receptor, mu 1 (rattus norvegicus) (aka opioid receptor, mu 1)
D: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
E: nop (mus musculus) (opioid receptor-like 1 (mus musculus)) (aka opioid receptor-like 1)
F: None of the above. | B |
<Instruct>: Given the context 'An 18 kb genomic clone hybridizing with the h mu OR1 cDNA contains 63 and 489 bp exonic sequences flanked by splice donor/acceptor sequences.', select the correct biomedical concept corresponding to 'h mu or1'. Answer using one of the provided options. | <Options>: A: or-1 (mus musculus) (aka nuclear receptor subfamily 1, group h, member 2)
B: m-or-1 (homo sapiens) (aka opioid receptor mu 1)
C: or51h1 (mus musculus) (aka olfactory receptor family 51 subfamily h member 1)
D: or1m1 (mus musculus) (aka olfactory receptor family 1 subfamily m member 1)
E: or1m1 (homo sapiens) (aka olfactory receptor family 1 subfamily m member 1)
F: None of the above. | B |
<Instruct>: Given the context 'Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes.
', select the correct biomedical concept corresponding to 'cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a synthase'. Answer using one of the provided options. | <Options>: A: 3-hydroxy-3-methylglutaryl-coenzyme a synthase 2 (mus musculus) (aka 3-hydroxy-3-methylglutaryl-coenzyme a synthase 2)
B: 3-hydroxy-3-methylglutaryl-coa reductase (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa reductase)
C: 3-hydroxy-3-methylglutaryl-coa synthase 1 (sus scrofa) (aka 3-hydroxy-3-methylglutaryl-coa synthase 1)
D: 3-hydroxy-3-methylglutaryl-coa lyase (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa lyase)
E: 3-hydroxy-3-methylglutaryl-coa synthase 1 (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa synthase 1)
F: None of the above. | E |
<Instruct>: Given the context 'A cDNA for the human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase (EC 4.1.3.5) was subcloned and expressed from a T7-based vector in Escherichia coli.', select the correct biomedical concept corresponding to 'cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) synthase'. Answer using one of the provided options. | <Options>: A: 3-hydroxy-3-methylglutaryl-coa synthase 1 (sus scrofa) (aka 3-hydroxy-3-methylglutaryl-coa synthase 1)
B: 3-oxoacyl-acp synthase, mitochondrial (homo sapiens) (aka 3-oxoacyl-acp synthase, mitochondrial)
C: 3-hydroxy-3-methylglutaryl-coenzyme a synthase 1 (mus musculus) (aka 3-hydroxy-3-methylglutaryl-coenzyme a synthase 1)
D: 3-hydroxy-3-methylglutaryl-coenzyme a synthase 1 (soluble) pseudogene (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coenzyme a synthase 1 (soluble) pseudogene)
E: hmgcs (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa synthase 1)
F: None of the above. | E |
<Instruct>: Given the context 'Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.
', select the correct biomedical concept corresponding to 'beta subunit of the high-affinity immunoglobulin e receptor'. Answer using one of the provided options. | <Options>: A: cd99b (homo sapiens) (aka cd99 molecule like 2)
B: cd179b (homo sapiens) (aka immunoglobulin lambda like polypeptide 1)
C: estrogen related receptor beta (bos taurus) (aka estrogen related receptor beta)
D: cd79b molecule (bos taurus) (aka cd79b molecule)
E: cd79b molecule (homo sapiens) (aka cd79b molecule)
F: None of the above. | F |
<Instruct>: Given the context 'The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis.', select the correct biomedical concept corresponding to 'beta-subunit of the high-affinity ige receptor'. Answer using one of the provided options. | <Options>: A: cd179b (homo sapiens) (aka immunoglobulin lambda like polypeptide 1)
B: cd79b molecule (homo sapiens) (aka cd79b molecule)
C: cd1b molecule (homo sapiens) (aka cd1b molecule)
D: cd99b (homo sapiens) (aka cd99 molecule like 2)
E: cd79b (bos taurus) (aka cd79b molecule)
F: None of the above. | F |
<Instruct>: Given the context 'The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis.', select the correct biomedical concept corresponding to 'beta-subunit of the high-affinity ige receptor'. Answer using one of the provided options. | <Options>: A: cd179b (homo sapiens) (aka immunoglobulin lambda like polypeptide 1)
B: cd79b molecule (bos taurus) (aka cd79b molecule)
C: cd99b (homo sapiens) (aka cd99 molecule like 2)
D: cd1b molecule (homo sapiens) (aka cd1b molecule)
E: igb (homo sapiens) (aka cd79b molecule)
F: None of the above. | F |
<Instruct>: Given the context 'The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis.', select the correct biomedical concept corresponding to 'fc epsilon ri-beta'. Answer using one of the provided options. | <Options>: A: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
B: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
C: cd16b (homo sapiens) (aka fc gamma receptor iiib)
D: fcgammariic (homo sapiens) (aka fc gamma receptor iic (gene/pseudogene))
E: fcgriib (homo sapiens) (aka fc gamma receptor iib)
F: None of the above. | F |
<Instruct>: Given the context 'We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain.', select the correct biomedical concept corresponding to 'fc epsilon ri-beta'. Answer using one of the provided options. | <Options>: A: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
B: fcgr1b (homo sapiens) (aka fc gamma receptor ib, pseudogene)
C: fcgriib (homo sapiens) (aka fc gamma receptor iib)
D: cd16b (homo sapiens) (aka fc gamma receptor iiib)
E: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
F: None of the above. | F |
<Instruct>: Given the context 'Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.', select the correct biomedical concept corresponding to 'fc epsilon ri-beta'. Answer using one of the provided options. | <Options>: A: fcriiib (homo sapiens) (aka fc gamma receptor iiib)
B: fcgammariic (homo sapiens) (aka fc gamma receptor iic (gene/pseudogene))
C: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
D: fcgammariib (homo sapiens) (aka fc gamma receptor iib)
E: fcgr1b (homo sapiens) (aka fc gamma receptor ib, pseudogene)
F: None of the above. | F |
<Instruct>: Given the context 'Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism.
', select the correct biomedical concept corresponding to 'thyrotropin receptor'. Answer using one of the provided options. | <Options>: A: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
B: thyrotropin releasing hormone receptor (rattus norvegicus) (aka thyrotropin releasing hormone receptor)
C: thyrotropin-releasing hormone receptor (bos taurus) (aka thyrotropin-releasing hormone receptor)
D: thyrotropin releasing hormone receptor (gallus gallus) (aka thyrotropin releasing hormone receptor)
E: thyrotropin releasing hormone receptor (bos taurus) (aka thyrotropin releasing hormone receptor)
F: None of the above. | A |
<Instruct>: Given the context 'The thyrotropin receptor (TSHR), a member of the large family of G protein-coupled receptors, controls both the function and growth of thyroid cells via stimulation of adenylyl cyclase.', select the correct biomedical concept corresponding to 'thyrotropin receptor'. Answer using one of the provided options. | <Options>: A: thyroid stimulating hormone receptor (rattus norvegicus) (aka thyroid stimulating hormone receptor)
B: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
C: thyrotropin releasing hormone receptor (gallus gallus) (aka thyrotropin releasing hormone receptor)
D: thyrotropin releasing hormone receptor (bos taurus) (aka thyrotropin releasing hormone receptor)
E: tshr (bos taurus) (aka thyroid stimulating hormone receptor)
F: None of the above. | B |
<Instruct>: Given the context 'The thyrotropin receptor (TSHR), a member of the large family of G protein-coupled receptors, controls both the function and growth of thyroid cells via stimulation of adenylyl cyclase.', select the correct biomedical concept corresponding to 'tshr'. Answer using one of the provided options. | <Options>: A: tshr (bos taurus) (aka thyroid stimulating hormone receptor)
B: thyrotropin releasing hormone receptor (bos taurus) (aka thyrotropin releasing hormone receptor)
C: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
D: trh-r (homo sapiens) (aka thyrotropin releasing hormone receptor)
E: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
F: None of the above. | E |
<Instruct>: Given the context 'We report two different mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) transmembrane segments.', select the correct biomedical concept corresponding to 'tshr'. Answer using one of the provided options. | <Options>: A: tshr (rattus norvegicus) (aka thyroid stimulating hormone receptor)
B: thyrotropin releasing hormone receptor (bos taurus) (aka thyrotropin releasing hormone receptor)
C: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
D: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
E: thyrotropin-releasing hormone receptor (bos taurus) (aka thyrotropin-releasing hormone receptor)
F: None of the above. | C |
<Instruct>: Given the context 'X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene.
', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: cyclin l1 (homo sapiens) (aka cyclin l1)
E: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
F: None of the above. | C |
<Instruct>: Given the context 'We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation.', select the correct biomedical concept corresponding to 'neural cell adhesion molecule l1'. Answer using one of the provided options. | <Options>: A: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
B: n-cam-l1 (mus musculus) (aka l1 cell adhesion molecule)
C: neural cell adhesion molecule 1 (homo sapiens) (aka neural cell adhesion molecule 1)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
F: None of the above. | E |
<Instruct>: Given the context 'We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation.', select the correct biomedical concept corresponding to 'l1cam'. Answer using one of the provided options. | <Options>: A: l1cam (gallus gallus) (aka l1 cell adhesion molecule)
B: l1cam (homo sapiens) (aka l1 cell adhesion molecule)
C: n-cam-l1 (mus musculus) (aka l1 cell adhesion molecule)
D: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
E: None of the above. | B |
<Instruct>: Given the context 'We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation.', select the correct biomedical concept corresponding to 'l1cam'. Answer using one of the provided options. | <Options>: A: l1cam (mus musculus) (aka l1 cell adhesion molecule)
B: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
C: l1cam (gallus gallus) (aka l1 cell adhesion molecule)
D: None of the above. | D |
<Instruct>: Given the context 'Here we report mutations of the L1 gene in MASA syndrome and SPG1, in addition to HSAS families.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
F: None of the above. | A |
<Instruct>: Given the context 'Two of the HSAS mutations would abolish cell surface expression of L1 and represent the first functional null mutations in this disorder.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: l1.1 (mus musculus) (aka skull morphology 1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
E: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
F: None of the above. | C |
<Instruct>: Given the context 'Our results indicate that these three syndromes from part of a clinical spectrum resulting from a heterogeneous group of mutations in the L1 gene.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1.1 (mus musculus) (aka skull morphology 1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
F: None of the above. | D |
<Instruct>: Given the context 'Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta.
Bradykinin exerts a broad spectrum of cellular effects on different tissues.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kallikrein b1 (bos taurus) (aka kallikrein b1)
B: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
C: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
D: bk (homo sapiens) (aka kininogen 1)
E: kininogen 1 (bos taurus) (aka kininogen 1)
F: None of the above. | D |
<Instruct>: Given the context 'Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta.
Bradykinin exerts a broad spectrum of cellular effects on different tissues.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kallikrein b1 (homo sapiens) (aka kallikrein b1)
B: bk (homo sapiens) (aka kininogen 1)
C: bradykinin (xenopus laevis) (bradykinin receptor b2 s homeolog (xenopus laevis)) (aka bradykinin receptor b2 s homeolog)
D: kallikrein 1 (bos taurus) (aka kallikrein 1)
E: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
F: None of the above. | B |
<Instruct>: Given the context 'It is believed that these effects are predominantly mediated by the recently cloned B2 receptor.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: adrb2r (homo sapiens) (aka adrenoceptor beta 2)
B: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
C: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
D: bkb1r (homo sapiens) (aka bradykinin receptor b1)
E: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
F: None of the above. | B |
<Instruct>: Given the context 'Involvement of protein kinase C (PKC) was suggested and activation of the classical PKC isoforms alpha and beta was recently demonstrated.', select the correct biomedical concept corresponding to 'pkc isoforms alpha'. Answer using one of the provided options. | <Options>: A: protein kinase camp-activated catalytic subunit alpha (homo sapiens) (aka protein kinase camp-activated catalytic subunit alpha)
B: protein kinase c, alpha (xenopus tropicalis) (aka protein kinase c, alpha)
C: prkaa (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
D: protein kinase c iota (homo sapiens) (aka protein kinase c iota)
E: protein kinase c alpha (homo sapiens) (aka protein kinase c alpha)
F: None of the above. | E |
<Instruct>: Given the context 'The aim of the present study was to investigate whether the B2 receptor also activates new (delta, epsilon) and atypical (zeta) PKC isoforms.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
B: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
C: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
D: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
E: bkb1r (homo sapiens) (aka bradykinin receptor b1)
F: None of the above. | B |
<Instruct>: Given the context 'To investigate this, chinese hamster ovary (CHO) cells, stably transfected with human B2 receptor, were used.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: b2r (homo sapiens) (aka bradykinin receptor b2)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
D: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
E: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
F: None of the above. | A |
<Instruct>: Given the context 'Stimulation of the cells with bradykinin resulted in a rapid (30-60 s) translocation of the PKC isoforms alpha, epsilon, and zeta.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kallikrein b1 (bos taurus) (aka kallikrein b1)
B: kininogen 1 (bos taurus) (aka kininogen 1)
C: bk (homo sapiens) (aka kininogen 1)
D: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
E: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
F: None of the above. | C |
<Instruct>: Given the context 'Stimulation of the cells with bradykinin resulted in a rapid (30-60 s) translocation of the PKC isoforms alpha, epsilon, and zeta.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kallikrein 1 (bos taurus) (aka kallikrein 1)
B: kallikrein b1 (bos taurus) (aka kallikrein b1)
C: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)
D: kallikrein b1 (homo sapiens) (aka kallikrein b1)
E: bradykinin (xenopus laevis) (bradykinin receptor b2 s homeolog (xenopus laevis)) (aka bradykinin receptor b2 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'Translocation of PKC delta was not detected.', select the correct biomedical concept corresponding to 'pkc delta'. Answer using one of the provided options. | <Options>: A: protein kinase c delta (bos taurus) (aka protein kinase c delta)
B: pkcd (homo sapiens) (aka protein kinase c delta)
C: pkcd (drosophila melanogaster) (aka protein kinase c delta)
D: protein kinase c delta (xenopus tropicalis) (aka protein kinase c delta)
E: None of the above. | B |
<Instruct>: Given the context 'The effect of bradykinin was reduced by simultaneous addition of the receptor antagonist HOE 140, a bradykinin-related decapeptide.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: kallikrein 1 (bos taurus) (aka kallikrein 1)
B: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)
C: bk (homo sapiens) (aka kininogen 1)
D: kallikrein b1 (homo sapiens) (aka kallikrein b1)
E: kallikrein b1 (bos taurus) (aka kallikrein b1)
F: None of the above. | C |
<Instruct>: Given the context 'The effect of bradykinin was reduced by simultaneous addition of the receptor antagonist HOE 140, a bradykinin-related decapeptide.', select the correct biomedical concept corresponding to 'bradykinin'. Answer using one of the provided options. | <Options>: A: bk (homo sapiens) (aka kininogen 1)
B: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
C: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
D: kininogen 1 (bos taurus) (aka kininogen 1)
E: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)
F: None of the above. | A |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: bdkrb2 (homo sapiens) (aka bradykinin receptor b2)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
F: None of the above. | C |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept corresponding to 'pkc isoform alpha'. Answer using one of the provided options. | <Options>: A: prkaa (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
B: protein kinase c, alpha (xenopus tropicalis) (aka protein kinase c, alpha)
C: protein kinase c alpha (homo sapiens) (aka protein kinase c alpha)
D: protein kinase camp-activated catalytic subunit alpha (homo sapiens) (aka protein kinase camp-activated catalytic subunit alpha)
E: pkn-alpha (homo sapiens) (aka protein kinase n1)
F: None of the above. | C |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept corresponding to 'pkc isoform epsilon'. Answer using one of the provided options. | <Options>: A: npkc-epsilon (homo sapiens) (aka protein kinase c epsilon)
B: protein kinase c epsilon (sus scrofa) (aka protein kinase c epsilon)
C: protein kinase c, epsilon (rattus norvegicus) (aka protein kinase c, epsilon)
D: protein kinase c epsilon (bos taurus) (aka protein kinase c epsilon)
E: protein kinase c, epsilon (mus musculus) (aka protein kinase c, epsilon)
F: None of the above. | A |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept corresponding to 'pkc isoform zeta'. Answer using one of the provided options. | <Options>: A: protein kinase c, zeta (danio rerio) (aka protein kinase c, zeta)
B: pkc-zeta (xenopus laevis) (protein kinase c zeta l homeolog (xenopus laevis)) (aka protein kinase c zeta l homeolog)
C: pkc-zeta (xenopus laevis) (protein kinase c zeta s homeolog (xenopus laevis)) (aka protein kinase c zeta s homeolog)
D: protein kinase c zeta (bos taurus) (aka protein kinase c zeta)
E: pkc-zeta (homo sapiens) (aka protein kinase c zeta)
F: None of the above. | E |
<Instruct>: Given the context 'In this cell system similar results on PKC alpha, epsilon, and zeta were observed, suggesting that all three PKC isoforms are involved in signal transduction of the B2 receptor.', select the correct biomedical concept corresponding to 'b2 receptor'. Answer using one of the provided options. | <Options>: A: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: bdkrb2 (homo sapiens) (aka bradykinin receptor b2)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: b2ar (homo sapiens) (aka adrenoceptor beta 2)
F: None of the above. | C |
<Instruct>: Given the context 'Protein structure of fetal antigen 1 (FA1).', select the correct biomedical concept corresponding to 'fetal antigen 1'. Answer using one of the provided options. | <Options>: A: fetal and adult testis expressed 1 (homo sapiens) (aka fetal and adult testis expressed 1)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: feta (homo sapiens) (alpha fetoprotein (homo sapiens)) (aka alpha fetoprotein)
D: fat1 (homo sapiens) (aka fat atypical cadherin 1)
E: fam1a (homo sapiens) (aka metallophosphoesterase domain containing 1)
F: None of the above. | F |
<Instruct>: Given the context 'Protein structure of fetal antigen 1 (FA1).', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa complementation group i (homo sapiens) (aka fa complementation group i)
B: faf1 (homo sapiens) (aka fas associated factor 1)
C: fa (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
F: None of the above. | F |
<Instruct>: Given the context 'Protein structure of fetal antigen 1 (FA1).', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
B: faf1 (homo sapiens) (aka fas associated factor 1)
C: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
F: None of the above. | F |
<Instruct>: Given the context 'A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.
', select the correct biomedical concept corresponding to 'dlk'. Answer using one of the provided options. | <Options>: A: dlk2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
B: dlk (drosophila melanogaster) (leucokinin (drosophila melanogaster)) (aka leucokinin)
C: dlk1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
D: dlk/zpk (drosophila melanogaster) (aka wallenda)
E: dlg (drosophila melanogaster) (discs large 1 (drosophila melanogaster)) (aka discs large 1)
F: None of the above. | C |
<Instruct>: Given the context 'A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.
', select the correct biomedical concept corresponding to 'pg2'. Answer using one of the provided options. | <Options>: A: pg2 (homo sapiens) (aka delta like non-canonical notch ligand 1)
B: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
C: pgm2 (homo sapiens) (aka phosphoglucomutase 2)
D: pgap2 (homo sapiens) (aka post-gpi attachment to proteins 2)
E: polygalacturonase pg2 (glycine max) (aka polygalacturonase pg2)
F: None of the above. | A |
<Instruct>: Given the context 'The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid.', select the correct biomedical concept corresponding to 'fetal antigen 1'. Answer using one of the provided options. | <Options>: A: fmr1 autosomal homolog 1 (danio rerio) (aka fmr1 autosomal homolog 1)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: fat1 (homo sapiens) (aka fat atypical cadherin 1)
D: atrial fibrillation, familial 1 (homo sapiens) (aka atrial fibrillation, familial 1)
E: fet1 (homo sapiens) (aka dopamine receptor d3)
F: None of the above. | F |
<Instruct>: Given the context 'The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: faf1 (homo sapiens) (aka fas associated factor 1)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: fa complementation group i (homo sapiens) (aka fa complementation group i)
D: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
E: fa complementation group a (homo sapiens) (aka fa complementation group a)
F: None of the above. | F |
<Instruct>: Given the context 'FA1 is a single-chained, heterogeneous glycoprotein of 225-262 amino acid residues.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
B: fa complementation group i (homo sapiens) (aka fa complementation group i)
C: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
D: fa complementation group a (homo sapiens) (aka fa complementation group a)
E: fa complementation group f (homo sapiens) (aka fa complementation group f)
F: None of the above. | F |
<Instruct>: Given the context 'FA1 has six well conserved epidermal-growth-factor motifs and contains up to ten O-glycosylation and N-glycosylation sites, six of which are differentially glycosylated.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
B: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
C: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: fa complementation group i (homo sapiens) (aka fa complementation group i)
F: None of the above. | F |
<Instruct>: Given the context 'Alignment to the translated sequences of Mus. musculus dlk and human dlk revealed 86% and 99% identity, respectively, to a 259-amino-acid residue overlap, and this high similarity extends with minor corrections to the human adrenal-specific mRNA, pG2 as well.', select the correct biomedical concept corresponding to 'dlk'. Answer using one of the provided options. | <Options>: A: dlk/zpk (drosophila melanogaster) (aka wallenda)
B: dlk (drosophila melanogaster) (leucokinin (drosophila melanogaster)) (aka leucokinin)
C: dlk-2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
D: dlk1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
E: dlg (drosophila melanogaster) (discs large 2 (drosophila melanogaster)) (aka discs large 2)
F: None of the above. | D |
<Instruct>: Given the context 'Alignment to the translated sequences of Mus. musculus dlk and human dlk revealed 86% and 99% identity, respectively, to a 259-amino-acid residue overlap, and this high similarity extends with minor corrections to the human adrenal-specific mRNA, pG2 as well.', select the correct biomedical concept corresponding to 'dlk'. Answer using one of the provided options. | <Options>: A: dlk-1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
B: dlk/zpk (drosophila melanogaster) (aka wallenda)
C: dlg (drosophila melanogaster) (discs large 2 (drosophila melanogaster)) (aka discs large 2)
D: dlk (drosophila melanogaster) (leucokinin (drosophila melanogaster)) (aka leucokinin)
E: dlak (drosophila melanogaster) (aka i-kappab kinase beta)
F: None of the above. | A |
<Instruct>: Given the context 'Alignment to the translated sequences of Mus. musculus dlk and human dlk revealed 86% and 99% identity, respectively, to a 259-amino-acid residue overlap, and this high similarity extends with minor corrections to the human adrenal-specific mRNA, pG2 as well.', select the correct biomedical concept corresponding to 'pg2'. Answer using one of the provided options. | <Options>: A: phosphoglycerate kinase 2 (homo sapiens) (aka phosphoglycerate kinase 2)
B: pgk2 (homo sapiens) (phosphoglycerate kinase 1, pseudogene 2 (homo sapiens)) (aka phosphoglycerate kinase 1, pseudogene 2)
C: pgm2 (homo sapiens) (aka phosphoglucomutase 2)
D: pgdp2 (homo sapiens) (aka phosphogluconate dehydrogenase pseudogene 2)
E: pg2 (homo sapiens) (aka delta like non-canonical notch ligand 1)
F: None of the above. | E |
<Instruct>: Given the context 'Immunohistochemical analysis demonstrated the presence of FA1 in 10 out of 14 lung tumors containing neuroendocrine elements, and in the placental villi where FA1 was exclusively seen in stromal cells in close contact to the vascular structure.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
B: fa complementation group f (homo sapiens) (aka fa complementation group f)
C: faf1 (homo sapiens) (aka fas associated factor 1)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: fa complementation group i (homo sapiens) (aka fa complementation group i)
F: None of the above. | F |
<Instruct>: Given the context 'Immunohistochemical analysis demonstrated the presence of FA1 in 10 out of 14 lung tumors containing neuroendocrine elements, and in the placental villi where FA1 was exclusively seen in stromal cells in close contact to the vascular structure.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
B: faf1 (homo sapiens) (aka fas associated factor 1)
C: fa complementation group i (homo sapiens) (aka fa complementation group i)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
F: None of the above. | F |
<Instruct>: Given the context 'Immunohistochemical analysis demonstrated the presence of FA1 in 10 out of 14 lung tumors containing neuroendocrine elements, and in the placental villi where FA1 was exclusively seen in stromal cells in close contact to the vascular structure.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
B: fa complementation group f (homo sapiens) (aka fa complementation group f)
C: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
D: fa complementation group i (homo sapiens) (aka fa complementation group i)
E: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
F: None of the above. | F |
<Instruct>: Given the context 'In the pancreas, FA1 co-localized with insulin in the insulin secretory granules of the beta cells within the islets of Langerhans.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa1 (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
B: fa complementation group i (homo sapiens) (aka fa complementation group i)
C: fa complementation group f (homo sapiens) (aka fa complementation group f)
D: faf1 (homo sapiens) (aka fas associated factor 1)
E: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
F: None of the above. | F |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA pG2.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
B: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
C: fa complementation group i (homo sapiens) (aka fa complementation group i)
D: fa1 (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
E: fa complementation group f (homo sapiens) (aka fa complementation group f)
F: None of the above. | F |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA pG2.', select the correct biomedical concept corresponding to 'fa1'. Answer using one of the provided options. | <Options>: A: fa complementation group i (homo sapiens) (aka fa complementation group i)
B: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
C: fa (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
D: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
E: faf1 (homo sapiens) (aka fas associated factor 1)
F: None of the above. | F |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA pG2.', select the correct biomedical concept corresponding to 'dlk'. Answer using one of the provided options. | <Options>: A: dlg (drosophila melanogaster) (discs large 1 (drosophila melanogaster)) (aka discs large 1)
B: dlk2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
C: dlg (drosophila melanogaster) (discs large 2 (drosophila melanogaster)) (aka discs large 2)
D: dlk-1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
E: dlk/zpk (drosophila melanogaster) (aka wallenda)
F: None of the above. | D |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA pG2.', select the correct biomedical concept corresponding to 'pg2'. Answer using one of the provided options. | <Options>: A: pg2 (homo sapiens) (aka delta like non-canonical notch ligand 1)
B: phosphoglycerate kinase 2 (homo sapiens) (aka phosphoglycerate kinase 2)
C: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
D: pgk2 (homo sapiens) (phosphoglycerate kinase 1, pseudogene 2 (homo sapiens)) (aka phosphoglycerate kinase 1, pseudogene 2)
E: pgap2 (homo sapiens) (aka post-gpi attachment to proteins 2)
F: None of the above. | A |
<Instruct>: Given the context 'Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.
', select the correct biomedical concept corresponding to 'dna helicase ii'. Answer using one of the provided options. | <Options>: A: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
B: uv-ddb2 (homo sapiens) (aka damage specific dna binding protein 2)
C: dna helicase b (homo sapiens) (aka dna helicase b)
D: dbp2 (homo sapiens) (aka deah-box helicase 16)
E: dna replication helicase/nuclease 2 (homo sapiens) (aka dna replication helicase/nuclease 2)
F: None of the above. | F |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select the correct biomedical concept corresponding to 'dna helicase ii'. Answer using one of the provided options. | <Options>: A: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
B: dbp2 (homo sapiens) (aka deah-box helicase 16)
C: dna helicase b (homo sapiens) (aka dna helicase b)
D: dna helicase ii (escherichia coli str. k-12 substr. mg1655) (aka dna helicase ii)
E: dna replication helicase/nuclease 2 (homo sapiens) (aka dna replication helicase/nuclease 2)
F: None of the above. | F |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select the correct biomedical concept corresponding to 'hdh ii'. Answer using one of the provided options. | <Options>: A: phd2 (homo sapiens) (aka egl-9 family hypoxia inducible factor 1)
B: hd2 (homo sapiens) (aka histone deacetylase 2)
C: d2h (homo sapiens) (aka solute carrier family 3 member 1)
D: cphd2 (homo sapiens) (aka prop paired-like homeobox 1)
E: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
F: None of the above. | F |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept corresponding to 'hdh ii'. Answer using one of the provided options. | <Options>: A: hdhd2b (homo sapiens) (aka phospholysine phosphohistidine inorganic pyrophosphate phosphatase)
B: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
C: d2h (homo sapiens) (aka solute carrier family 3 member 1)
D: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
E: cphd2 (homo sapiens) (aka prop paired-like homeobox 1)
F: None of the above. | F |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept corresponding to 'hdh ii'. Answer using one of the provided options. | <Options>: A: cphd2 (homo sapiens) (aka prop paired-like homeobox 1)
B: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
C: dcoh2 (homo sapiens) (aka pterin-4 alpha-carbinolamine dehydratase 2)
D: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
E: hd2 (homo sapiens) (aka histone deacetylase 2)
F: None of the above. | F |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept corresponding to 'heterodimer of 72 and 87 kda polypeptides'. Answer using one of the provided options. | <Options>: A: cep72 (homo sapiens) (aka centrosomal protein 72)
B: signal recognition particle 72 (homo sapiens) (aka signal recognition particle 72)
C: hh72 (homo sapiens) (aka protein tyrosine phosphatase 4a1)
D: hst17287 (homo sapiens) (aka aquaporin 9)
E: p87/89 (homo sapiens) (aka inner membrane mitochondrial protein)
F: None of the above. | F |
<Instruct>: Given the context 'The antibodies raised in rabbit against either polypeptide can remove from the solution all the activities of HDH II.', select the correct biomedical concept corresponding to 'hdh ii'. Answer using one of the provided options. | <Options>: A: d2h (homo sapiens) (aka solute carrier family 3 member 1)
B: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
C: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
D: hd2 (homo sapiens) (aka histone deacetylase 2)
E: hdhd2b (homo sapiens) (aka phospholysine phosphohistidine inorganic pyrophosphate phosphatase)
F: None of the above. | F |
<Instruct>: Given the context 'Microsequencing of the separate polypeptides of HDH II and cross-reaction with specific antibodies showed that this enzyme is identical to Ku, an autoantigen recognized by the sera of scleroderma and lupus erythematosus patients, which binds specifically to duplex DNA ends and is regulator of a DNA-dependent protein kinase.', select the correct biomedical concept corresponding to 'hdh ii'. Answer using one of the provided options. | <Options>: A: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
B: hdhd2b (homo sapiens) (aka phospholysine phosphohistidine inorganic pyrophosphate phosphatase)
C: hph-2 (homo sapiens) (aka egl-9 family hypoxia inducible factor 1)
D: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
E: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
F: None of the above. | F |
<Instruct>: Given the context 'Recombinant HDH II/Ku protein expressed in and purified from Escherichia coli cells showed DNA binding and helicase activities indistinguishable from those of the isolated protein.', select the correct biomedical concept corresponding to 'hdh ii/ku'. Answer using one of the provided options. | <Options>: A: kud (homo sapiens) (aka transmembrane protein 258)
B: lethal (2) histolytic (drosophila melanogaster) (aka lethal (2) histolytic)
C: atp-dependent dna helicase ii subunit 2;ku c-terminal domain-containing protein;ku_pk_bind domain-containing protein (caenorhabditis elegans) (aka atp-dependent dna helicase ii subunit 2;ku c-terminal domain-containing protein;ku_pk_bind domain-containing protein)
D: kub3 (homo sapiens) (aka atp23 metallopeptidase and atp synthase assembly factor homolog)
E: kub2 (homo sapiens) (aka x-ray repair cross complementing 5)
F: None of the above. | E |
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