instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'Comparison of the human sequence with rat G(olf) alpha shows 91% nucleotide identity (within the coding region) and 99% identity at the amino acid level.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of the provided options. | <Options>: A: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine nucleotide-binding protein g(olf) subunit alpha-like)
B: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
C: g protein alpha subunit (glycine max) (aka g protein alpha subunit)
D: gnas... | B |
<Instruct>: Given the context 'Northern and reverse transcriptase-polymerase chain reaction analyses indicated that G(olf) alpha is expressed in all human insulinomas examined thus far as well as in normal pancreatic islets.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of th... | <Options>: A: galpha(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
B: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
C: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine n... | B |
<Instruct>: Given the context 'G(olf) alpha mRNA was also detected in testis, retina, brain, and liver.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of the provided options. | <Options>: A: galpha(olf) (xenopus tropicalis) (aka g protein subunit alpha l)
B: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
C: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melanogaster)) (aka g protein alpha subu... | E |
<Instruct>: Given the context 'Western blot analysis of various mouse tissues demonstrated that the level of G(olf) alpha protein in islets is lower than that in the olfactory neuroepithelium and other parts of the brain; its expression in retina, lung, and spleen was moderately higher than that in islets, and its expr... | <Options>: A: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
B: g(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
C: guanine nucleotide-binding protein g(olf) subunit alph... | D |
<Instruct>: Given the context 'G(olf) alpha was also detected by immunohistochemistry in mouse islets, human insulinomas, the epithelial lining of mouse epididymis, photoreceptor cells of mouse retina, and mouse lung alveoli.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of t... | <Options>: A: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine nucleotide-binding protein g(olf) subunit alpha-like)
B: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
C: gnas/l (drosophila melano... | D |
<Instruct>: Given the context 'G(olf) alpha was also detected by immunohistochemistry in mouse islets, human insulinomas, the epithelial lining of mouse epididymis, photoreceptor cells of mouse retina, and mouse lung alveoli.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of t... | <Options>: A: galpha(olf) (xenopus tropicalis) (aka g protein subunit alpha l)
B: g protein alpha subunit (glycine max) (aka g protein alpha subunit)
C: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine nucleotide-binding protein g(olf) subunit alpha-like)
D: galpha(olf) ... | F |
<Instruct>: Given the context 'These findings suggest a role for G(olf) alpha in a diverse population of cells located outside the olfactory neuroepithelium and central nervous system.', select the correct biomedical concept corresponding to 'g(olf) alpha'. Answer using one of the provided options. | <Options>: A: galpha(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
B: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
C: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subu... | B |
<Instruct>: Given the context 'Regions of similarity were also seen between the amino acid sequences of the 140-kDa subunit of RFC, poly(ADP-ribose) polymerase, and bacterial DNA ligases--possibly representing a conserved structural feature of these proteins that bind similar DNA substrates.', select the correct biomed... | <Options>: A: replication factor c subunit 1 (saccharomyces cerevisiae s288c) (aka replication factor c subunit 1)
B: rfc4 (saccharomyces cerevisiae s288c) (aka replication factor c subunit 4)
C: rfc5 (saccharomyces cerevisiae s288c) (aka replication factor c subunit 5)
D: replication factor c subunit 1 (homo sapiens) ... | D |
<Instruct>: Given the context 'Molecular cloning and centrosomal localization of human caltractin.
Caltractin, a 20-kDa calcium-binding protein, was previously purified and cloned at the DNA level from the unicellular green alga Chlamydomonas.', select the correct biomedical concept corresponding to 'caltractin'. Answe... | <Options>: A: caltractin-like (xenopus laevis) (aka caltractin-like)
B: caltractin (xenopus laevis) (aka caltractin)
C: caltractin (xenopus tropicalis) (aka caltractin)
D: caln1 (homo sapiens) (aka calneuron 1)
E: calt (homo sapiens) (aka centrin 2)
F: None of the above. | E |
<Instruct>: Given the context 'Molecular cloning and centrosomal localization of human caltractin.
Caltractin, a 20-kDa calcium-binding protein, was previously purified and cloned at the DNA level from the unicellular green alga Chlamydomonas.', select the correct biomedical concept corresponding to 'caltractin'. Answe... | <Options>: A: caltractin-like (xenopus laevis) (aka caltractin-like)
B: caltractin (xenopus tropicalis) (aka caltractin)
C: calbindin 2 (homo sapiens) (aka calbindin 2)
D: calt (homo sapiens) (aka centrin 2)
E: calbindin (xenopus tropicalis) (aka calbindin 1)
F: None of the above. | D |
<Instruct>: Given the context 'Here we report the characterization of a cDNA encoding a human caltractin that shares a high degree of amino acid identity (70%) with its algal counterpart.', select the correct biomedical concept corresponding to 'caltractin'. Answer using one of the provided options. | <Options>: A: caln (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
B: caln1 (homo sapiens) (aka calneuron 1)
C: calbindin 1 (homo sapiens) (aka calbindin 1)
D: calt (homo sapiens) (aka centrin 2)
E: caltractin (xenopus tropicalis) (aka caltractin)
F: None of the above. | D |
<Instruct>: Given the context 'Caltractin was identified in both HeLa and BHK cells as a 21-kDa polypeptide specifically localized to the centrosome of interphase and mitotic cells.', select the correct biomedical concept corresponding to 'caltractin'. Answer using one of the provided options. | <Options>: A: calbindin (xenopus tropicalis) (aka calbindin 1)
B: caln1 (homo sapiens) (aka calneuron 1)
C: caltractin (xenopus laevis) (aka caltractin)
D: calt (homo sapiens) (aka centrin 2)
E: calumenin (homo sapiens) (aka calumenin)
F: None of the above. | D |
<Instruct>: Given the context 'The high level of conservation in the amino acid sequence of caltractin from algae to humans and its association with the major microtubule-organizing center in the cell suggest that caltractin plays a fundamental role in microtubule-organizing center structure and function.', select the ... | <Options>: A: calumenin (homo sapiens) (aka calumenin)
B: caltractin (xenopus tropicalis) (aka caltractin)
C: calt (homo sapiens) (aka centrin 2)
D: caltractin-like (xenopus laevis) (aka caltractin-like)
E: calbindin 2 (homo sapiens) (aka calbindin 2)
F: None of the above. | C |
<Instruct>: Given the context 'The high level of conservation in the amino acid sequence of caltractin from algae to humans and its association with the major microtubule-organizing center in the cell suggest that caltractin plays a fundamental role in microtubule-organizing center structure and function.', select the ... | <Options>: A: caltractin-like (xenopus laevis) (aka caltractin-like)
B: calbindin (xenopus tropicalis) (aka calbindin 1)
C: calumenin (homo sapiens) (aka calumenin)
D: calbindin 1 (homo sapiens) (aka calbindin 1)
E: calt (homo sapiens) (aka centrin 2)
F: None of the above. | E |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept corresponding to 'estrogen-responsive finger protein'. Answer using one of the provided options. | <Options>: A: ring finger protein-like (homo sapiens) (aka ring finger protein-like)
B: ring finger protein-like (bos taurus) (aka ring finger protein-like)
C: rlf zinc finger (homo sapiens) (aka rlf zinc finger)
D: finger5 (homo sapiens) (aka yip1 domain family member 5)
E: e3 ubiquitin-protein ligase itchy homolog (b... | F |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
B: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
C: epfn (homo sapiens) (aka sp6 transcription factor)
D: efp (homo sapiens) (aka tripartite motif containing 25)
E: epf (homo sapiens) (aka heat shock pr... | D |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
B: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
C: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
D: efp (escherichia coli str. k-12 substr. mg1655) (aka prot... | F |
<Instruct>: Given the context 'efp cDNA contains a consensus estrogen-responsive element at the 3' untranslated region that can act as a downstream estrogen-dependent enhancer.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efg1 (homo sapiens) (aka g elongation factor mitochondrial 1)
B: efp (homo sapiens) (aka tripartite motif containing 25)
C: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
D: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
E: efp (escherichia coli str... | B |
<Instruct>: Given the context 'Moreover, efp is regulated by estrogen as demonstrated at both the mRNA and the protein level in ER-positive cells derived from mammary gland.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efg1 (homo sapiens) (aka g elongation factor mitochondrial 1)
B: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
C: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
D: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
E: efp (homo sapiens) (aka t... | E |
<Instruct>: Given the context 'These data suggest that efp may represent an estrogen-responsive transcription factor that mediates phenotypic expression of the diverse estrogen action.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efp (homo sapiens) (aka tripartite motif containing 25)
B: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
C: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
D: efc (homo sapiens) (aka regulatory factor x1)
E: efp (escherichia coli str. k-12 substr. mg16... | A |
<Instruct>: Given the context 'A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lon protease (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
B: lon (drosophila melanogaster) (lon protease (drosophila melanogaster)) (aka lon protease)
C: lon peptidase 1, mitochondrial (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon-1 (caenorhabditis elegans) (aka protein lon-... | A |
<Instruct>: Given the context 'A single species of mRNA was found for this Lon protease in all human tissues examined.', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
B: lon protease (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
C: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
D: lon peptidase 1, mitochondrial (homo ... | D |
<Instruct>: Given the context 'Immunofluorescence microscopy suggested a predominantly mitochondrial localization for the Lon protease in cultured human cells.', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
B: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
C: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
D: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
E... | D |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correc... | <Options>: A: lon (mus musculus) (aka lon peptidase 1, mitochondrial)
B: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
C: lon peptidase 1, mitochondrial (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E: lon-1 (caenorhabditis elegans) (... | D |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correc... | <Options>: A: lon (drosophila melanogaster) (lon protease (drosophila melanogaster)) (aka lon protease)
B: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
C: lonp1 (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon-1 (caenorhabditis elegans) (aka protein lo... | E |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'beta/a4-protein'. Answer using one of the provided options. | <Options>: A: tubb4a (homo sapiens) (aka tubulin beta 4a class iva)
B: crystallin beta a4 (homo sapiens) (aka crystallin beta a4)
C: a4a (homo sapiens) (aka immunoglobulin kappa variable 1d-27 (pseudogene))
D: beta-4 (homo sapiens) (adaptor related protein complex 4 subunit beta 1 (homo sapiens)) (aka adaptor related p... | F |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
B: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
C: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
D: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
E: arpn-beta (homo sapiens) (aka actin like 6a)... | F |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: arpn-beta (homo sapiens) (aka actin like 6a)
B: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
C: actb (homo sapiens) (actin beta (homo sapiens)) (aka actin beta)
D: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
E: accbeta (homo sapiens) (aka acetyl-coa ca... | F |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: beta-naca (homo sapiens) (aka basic transcription factor 3)
B: nac (drosophila melanogaster) (neuronally altered carbohydrate (drosophila melanogaster)) (aka neuronally altered carbohydrate)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nacae ... | C |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'non-a beta component of ad amyloid'. Answer using one of the provided options. | <Options>: A: synuclein alpha (rattus norvegicus) (aka synuclein alpha)
B: alzheimer disease 8 (homo sapiens) (aka alzheimer disease 8)
C: snca (homo sapiens) (aka synuclein alpha)
D: amyloid beta precursor protein (homo sapiens) (aka amyloid beta precursor protein)
E: adnp (homo sapiens) (aka activity dependent neurop... | C |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
B: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
C: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
D: nac (drosophila melanogaster) (nascent pol... | E |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
C: beta-naca (homo sapiens) (aka basic transcription factor 3)
D: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
E: nacae (homo sapiens) (aka solute ... | A |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: actr1b (homo sapiens) (aka actin related protein 1b)
B: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
C: arpn-beta (homo sapiens) (aka actin like 6a)
D: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
E: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
F: None of the above... | F |
<Instruct>: Given the context 'Secondary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: nacae (homo sapiens) (aka solute carrier family 3 member 2)
C: nacb (homo sapiens) (aka basic transcription factor 3)
D: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
E: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
F: None... | A |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
D: nacb (homo sapiens) (aka basic transcription factor 3)
E: naca (homo sapiens) (aka nascent polypeptide associated complex subunit... | B |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
D: nac (drosophila melanogaster) (nascent polypeptide associated complex protein a... | B |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
B: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
C: nacb (homo sapiens) (aka basic transcription factor 3)
D: nacp (homo sapiens) (aka synuclein alpha)
E: nac (drosophila melanogaster) (nascent polypep... | D |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided option... | <Options>: A: nacb (homo sapiens) (aka basic transcription factor 3)
B: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nac domain protein nac1 ... | C |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided option... | <Options>: A: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: nacb (homo sapiens) (aka basic transcription factor 3)
D: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
E: naca (homo sapiens) (aka nascent polypept... | F |
<Instruct>: Given the context 'The availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidosis in AD.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
B: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
C: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
D: nacb (homo sapiens) (aka basic transcription factor ... | E |
<Instruct>: Given the context 'Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
B: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
C: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
D: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite re... | C |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept corresponding to '... | <Options>: A: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
B: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
C: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
D: nrf-1 (xenopus tropicalis) (aka nuclear respira... | E |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept corresponding to '... | <Options>: A: nfe2l1 (rattus norvegicus) (aka nfe2 like bzip transcription factor 1)
B: nfe2 like bzip transcription factor 1 (xenopus tropicalis) (aka nfe2 like bzip transcription factor 1)
C: nfe2l1_retired (rattus norvegicus) (aka nuclear respiratory factor 1)
D: nuclear factor, erythroid 2 like 1 (gallus gallus) (a... | E |
<Instruct>: Given the context 'Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
B: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
C: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
D: nrf-1 (xenopus tropicalis)... | E |
<Instruct>: Given the context 'Nrf1 activates transcription via NF-E2 binding sites in yeast cells.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrf1 (homo sapiens) (nfe2 like bzip transcription factor 1 (homo sapiens)) (aka nfe2 like bzip transcription factor 1)
B: nrf (homo sapiens) (aka nfkb repressing factor)
C: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
D: nrff (escherichia coli str. k-12 substr. mg1655) (aka putativ... | A |
<Instruct>: Given the context 'The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the p... | <Options>: A: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
B: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
C: nrf (homo sapiens) (aka nfkb repressing factor)
D: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
E: nrff (escherichia coli str. k-12 substr. mg1655) (aka putat... | A |
<Instruct>: Given the context 'Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa.
', select the correct biomedical concept corresponding to 'beta-subunit of rod phosphodiesterase'. Answer using one of the provided options. | <Options>: A: phosphodiesterase 6b, cgmp-specific, rod, beta (danio rerio) (aka phosphodiesterase 6b, cgmp-specific, rod, beta)
B: pde6b (homo sapiens) (aka phosphodiesterase 6b)
C: rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit beta-like (xenopus laevis) (aka rod cgmp-specific 3',5'-cyclic phosphodiesterase ... | B |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'beta-subuni... | <Options>: A: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
B: pde8b (homo sapiens) (aka phosphodiesterase 8b)
C: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
D: pde6b (homo sapiens) (aka phosphodiesterase 6b)
E: pdes1b (ho... | D |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'pde beta'. ... | <Options>: A: pde8b (homo sapiens) (aka phosphodiesterase 8b)
B: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
C: pde7b (homo sapiens) (aka phosphodiesterase 7b)
D: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
E: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
F: None of the abo... | E |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'pde beta'. ... | <Options>: A: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
B: pde7b (homo sapiens) (aka phosphodiesterase 7b)
C: pde3b (homo sapiens) (aka phosphodiesterase 3b)
D: pde8b (homo sapiens) (aka phosphodiesterase 8b)
E: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
F: None of the above. | F |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept correspondi... | <Options>: A: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
B: pde3b (homo sapiens) (aka phosphodiesterase 3b)
C: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
D: pde6b (homo sapiens) (aka phosphodiesterase 6b)
E: pde7b (homo sapiens) (aka phosphodiesterase 7b)
F: None of the above. | D |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept correspondi... | <Options>: A: rhodopsin (homo sapiens) (aka rhodopsin)
B: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka retinal pigment epithelium-derived rhodopsin homolog)
C: retinal pigment epithelium-derived rhodopsin homolog (homo sapiens) (aka retinal pigment epithelium-derived rhodopsin homolog)... | A |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided options. | <Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral ... | D |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nuclea... | A |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the provided options. | <Options>: A: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: nfkb-p50 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo... | D |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provided options. | <Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
C: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
D: lyt-10 (homo sapiens) (aka nuclear factor ... | D |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided... | <Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
B: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogen... | E |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the ... | <Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nu... | E |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the ... | <Options>: A: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nf-kb2 (homo sapiens) (aka nu... | C |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provide... | <Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig do... | B |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provide... | <Options>: A: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily me... | F |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided options. | <Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
C: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus ... | D |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the provided options. | <Options>: A: nfkb-p50 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
D: rela proto-oncogene, nf-kb subunit... | A |
<Instruct>: Given the context 'The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provided options. | <Options>: A: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
B: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: interleukin 10 (homo sapiens) (aka interleukin 10)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: c-x-c motif chemokine ligand 10... | B |
<Instruct>: Given the context 'NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types.', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
C: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: rela proto-oncogene, nf-kb subunit... | B |
<Instruct>: Given the context 'Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.
', select the correct biomedical concept corresponding to 'valyl-trna synthetase'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
C: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 1 ... | D |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept corresponding to 'valyl-trna synthetase'. Answer using one of the pr... | <Options>: A: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
B: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
C: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (ak... | F |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
B: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
C: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
D: valyl-tr... | E |
<Instruct>: Given the context 'Three independent plaque clones containing the human TrsVal cDNA were then isolated from a lambda gt10 human erythroleukemia cDNA library using the rat cDNA fragment as the hybridization probe.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the prov... | <Options>: A: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase / va... | B |
<Instruct>: Given the context 'The deduced 1051-amino-acid sequence shares 65% identity with yeast TrsVal, and contains a highly basic N-terminal region, a newly evolved protease-sensitive region in sequence close to the C terminus, and several sites for protein kinase C phosphorylation.', select the correct biomedical... | <Options>: A: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
B: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
C: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
D: valine--... | C |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
D: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-t... | E |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
B: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
C: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka v... | F |
<Instruct>: Given the context 'These results confirm the cloning and sequencing of a human TrsVal-encoding cDNA.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
C: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
D: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthe... | A |
<Instruct>: Given the context 'Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.
', select the correct biomedical concept corresponding to 'calmodulin-like protein clp'. Answer using one of the provided options. | <Options>: A: caml (homo sapiens) (aka calcium modulating ligand)
B: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
C: calmodulin like 5 (homo sapiens) (aka calmodulin like 5)
D: calmodulin like 6 (homo sapiens) (aka calmodulin like 6)
E: calmodulin like 4 (homo sapiens) (aka calmodulin like 4)
F: None of the... | B |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept corresponding to 'calmodulin-like protein'. Answer using one of the provided options. | <Options>: A: calmodulin-like (glycine max) (aka calmodulin-like)
B: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
C: calmodulin-like protein;ef-hand domain-containing protein (caenorhabditis elegans) (aka calmodulin-like protein;ef-hand domain-containing protein)
D: camk-like (drosophila melanogaster) (aka ... | B |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clpa (homo sapiens) (aka t-box transcription factor 22)
B: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
D: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteo... | F |
<Instruct>: Given the context 'Chromosomal assignment was performed by Southern blot analysis of DNA from human-rodent somatic cell hybrids and amplification of a CLP gene-specific 1090-bp DNA fragment by the polymerase chain reaction (PCR) on DNA from human-hamster cell hybrids.', select the correct biomedical concept... | <Options>: A: clps (homo sapiens) (aka colipase)
B: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
D: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic... | F |
<Instruct>: Given the context 'The CLP gene is the first member of the human calmodulin/calmodulin-like gene family to be chromosomally sublocalized.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
B: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
C: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
D: clp-1 (homo sapiens) (aka cyclin and cbs do... | F |
<Instruct>: Given the context 'The generation of a human CLP gene-specific sequence tag site specified by the two primers used for PCR should prove useful for future linkage studies.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clps (homo sapiens) (aka colipase)
B: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
C: clpa (homo sapiens) (aka t-box transcription factor 22)
D: clpp.l (xenopus laevis) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit l homeolog)
E:... | F |
<Instruct>: Given the context 'A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes.', select the correct biomedical concept corresponding to 'cytochrome p-450 family 4'. Answer using one of the provided options. | <Options>: A: cytochrome p450 family 4 subfamily f member 2 (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 2)
B: cyp4f-se4[6:7:8] (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 29, pseudogene)
C: cytochrome p450 family 3 subfamily a member 4 (homo sapiens) (aka cytochrome p450 family 3... | E |
<Instruct>: Given the context 'cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
', select the correct biomedical concept corresponding to 'leukotriene b4 omega-hydroxylase'. Answer using one of the provided options. | <Options>: A: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
B: leukotriene-b(4) omega-hydroxylase 2-like (bos taurus) (aka leukotriene-b(4) omega-hydroxylase 2-like)
C: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
D: leukotriene a4 hydrolase (homo sapiens) (aka le... | E |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept corresponding to 'leukotriene b4 (ltb4) omega-hydroxylase'. Answer using one ... | <Options>: A: cytochrome p450 2b4-like l homeolog (xenopus laevis) (aka cytochrome p450 2b4-like l homeolog)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
D: arachidonate 5-lipoxygenase (homo sapiens) (aka arachidonate 5-lipoxygenase... | B |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept corresponding to 'leukotriene b4 (ltb4) omega-hydroxylase'. Answer using one ... | <Options>: A: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
B: cytochrome p450 2b4-like l homeolog (xenopus laevis) (aka cytochrome p450 2b4-like l homeolog)
C: leukotriene a-4 hydrolase-like (glycine max) (aka leukotriene a-4 hydrolase-like)
D: ltb4dh (homo sapiens) (aka pr... | F |
<Instruct>: Given the context 'The microsomes from yeast cells transfected with an expression vector pAAH5 carrying isolated cDNA catalyzed the omega-hydroxylation of LTB4 with a Km value of 0.71 microM, and its activity was significantly inhibited by carbon monoxide and by antisera against CYP4A4, consistent with the ... | <Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: lta4h (homo sapiens) (aka leukotriene a4 hydrolase)
C: 5-lox (homo sapiens) (aka arachidonate 5-lipoxygenase)
D: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
E: cyp2b4 (oryctolagus c... | A |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept corresponding to 'ltb4 omega-hydroxyl... | <Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
C: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
D: 5-lox (homo sapiens) (aka arachidonate 5-lipoxygenase)
E: lta4h (homo ... | A |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept corresponding to 'p-450ltb omega'. An... | <Options>: A: cytochrome p450 2b4-like (xenopus tropicalis) (aka cytochrome p450 2b4-like)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: p-450 2b5 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
D: p-450ib (oryctolagus cuniculus) (aka cytochrome p450 ... | B |
<Instruct>: Given the context 'According to the systematic classification of the P-450 superfamily, P-450LTB omega is classified into the CYP4 family but does not belong to any of the known CYP4 subfamilies.', select the correct biomedical concept corresponding to 'p-450ltb omega'. Answer using one of the provided opti... | <Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: cytochrome p450 lm4 (oryctolagus cuniculus) (aka cytochrome p450 lm4)
C: cytochrome p450 2c42-like (bos taurus) (aka cytochrome p450 2c42-like)
D: p-450ib (oryctolagus cuniculus) (aka cytochrome p450 family 2 subfamily j member 2)... | A |
<Instruct>: Given the context 'Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.
', select the correct biomedical concept corresponding to 'catalytic subunit of human dna polymerase epsilon'. Answer using one of the provided options. | <Options>: A: dna polymerase epsilon catalytic subunit (saccharomyces cerevisiae s288c) (aka dna polymerase epsilon catalytic subunit)
B: dna polymerase epsilon 3, accessory subunit (homo sapiens) (aka dna polymerase epsilon 3, accessory subunit)
C: dna polymerase epsilon 2, accessory subunit (homo sapiens) (aka dna po... | D |
<Instruct>: Given the context 'The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned.', select the correct biomedical concept corresponding to 'catalytic polypeptide of human dna polymerase epsilon'. Answer using one of the provided options. | <Options>: A: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
B: polymerase (dna directed), epsilon (mus musculus) (aka polymerase (dna directed), epsilon)
C: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)... | A |
<Instruct>: Given the context 'cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.
', select the correct biomedical concept corresponding to 'beta-subunit of the human electron-transfer flavoprotein'. Answer using one of the provided options. | <Options>: A: electron transferring flavoprotein, beta polypeptide (mus musculus) (aka electron transferring flavoprotein, beta polypeptide)
B: electron transfer flavoprotein subunit alpha (homo sapiens) (aka electron transfer flavoprotein subunit alpha)
C: hydroxyacyl-coa dehydrogenase trifunctional multienzyme comple... | E |
<Instruct>: Given the context 'We have isolated a cDNA clone which encodes the entire beta-subunit of human electron-transferring flavoprotein (ETF) by screening an expression library from human liver using polyclonal antibodies against porcine ETF.', select the correct biomedical concept corresponding to 'beta-subunit... | <Options>: A: electron transfer flavoprotein regulatory factor 1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
B: electron transferring flavoprotein, beta polypeptide (mus musculus) (aka electron transferring flavoprotein, beta polypeptide)
C: electron transfer flavoprotein subunit beta (bos t... | D |
<Instruct>: Given the context 'This cDNA encodes a protein of 255 amino-acid residues with a predicted molecular mass of 27,877 Da which shows a high degree of similarity with partial amino-acid sequences obtained from both rat liver and Paracoccus denitrificans beta-ETF.', select the correct biomedical concept corresp... | <Options>: A: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
B: etf (homo sapiens) (aka tea domain transcription factor 2)
C: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
D: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavopr... | D |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: etf (homo sapiens) (aka tea domain transcription factor 2)
B: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
C: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
D: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
E: tcfeb (homo sapiens) (... | D |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: ebf (homo sapiens) (aka ebf transcription factor 1)
B: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
C: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
D: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
E: hrtef-1b (homo sapiens) (aka tea domain transc... | F |
<Instruct>: Given the context 'Incubation with intact mitochondria indicates that the cDNA-encoded beta-ETF polypeptide contains the information necessary to reach the mitochondrial matrix.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
B: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
C: tcfeb (homo sapiens) (aka transcription factor eb)
D: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
E: hrtef-1b (homo sapiens) (aka tea do... | B |
<Instruct>: Given the context 'These data are in agreement with previous experiments suggesting that beta-ETF, unlike the majority of nuclear-encoded mitochondrial matrix proteins, does not have a cleavable leader peptide.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the prov... | <Options>: A: ebf (homo sapiens) (aka ebf transcription factor 1)
B: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
C: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
D: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
E: etf (homo sapiens) (aka tea d... | C |
<Instruct>: Given the context 'Interestingly, the sequence analysis of beta-ETF protein identifies a 26.3% identity with the Fix A gene product of the nitrogen-fixing bacterium Azorhizobium caulinodans.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
B: ebf (homo sapiens) (aka ebf transcription factor 1)
C: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
D: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
E: etfb (bos taurus) (aka electr... | A |
<Instruct>: Given the context 'Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library.', select the correct biomedical concept corresponding to 'glya'. Answer using one of the provided opti... | <Options>: A: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
B: gly1 (homo sapiens) (aka threonine aldolase 1, pseudogene)
C: glyi (homo sapiens) (aka glyoxalase i)
D: glya (escherichia coli str. k-12 substr. mg1655) (aka serine hydroxymethyltransferase)
E: gsa (glycine max) (aka glutamate 1-sem... | D |
<Instruct>: Given the context 'Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.
', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
B: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
C: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
D: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
E: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
F: None of... | E |
<Instruct>: Given the context 'CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively).', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided... | <Options>: A: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
B: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
C: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
D: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
E: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
F: None ... | E |
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