instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
values |
|---|---|---|
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept corresponding to 'eif2b'. Answer using one of the provided options. | <Options>: A: eif2b (homo sapiens) (eukaryotic translation initiation factor 2b subunit alpha (homo sapiens)) (aka eukaryotic translation initiation factor 2b subunit alpha)
B: eif2beta (homo sapiens) (aka eukaryotic translation initiation factor 2 subunit beta)
C: eif2bbeta (homo sapiens) (aka eukaryotic translation i... | E |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhac (homo sapiens) (aka protocadherin alpha constant)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin 10 (homo sapiens) (aka protocadherin 10)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
F: None ... | F |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: pcdh7 (homo sapiens) (aka protocadherin 7)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
F: None of the above. | F |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
F: None of... | F |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: protocadherin 10 (homo sapiens) (aka protocadherin 10)
B: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: protocadherin 7 (homo sapiens) (aka protocadherin 7)
F: None ... | F |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
D: protocadherin 7 (homo sapiens) (aka protocadherin 7)
E: pcdhac (homo sapiens) (aka protocadherin alpha constant)
F: None of the ab... | F |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: protocadherin 12 (homo sapiens) (aka protocadherin 12)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: protocadherin 7 (homo sapiens) (aka protocadherin 7)
F: None of the above. | F |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Ans... | <Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: protocadherin 10 (homo sapiens) (aka protocadherin 10)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
F: None of t... | F |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the provided options. | <Options>: A: pcdh7 (homo sapiens) (aka protocadherin 7)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
F: None of the above... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: tmem205 (xenopus tropicalis) (aka transmembrane protein 205)
B: tmem205 (sus scrofa) (aka transmembrane protein 205)
C: tmem205 (homo sapiens) (aka transmembrane protein 205)
D: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
E: mast 205 (drosophila melanogaster) (aka drop ou... | D |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: transmembrane protein 205 (mus musculus) (aka transmembrane protein 205)
B: mast205 (drosophila melanogaster) (aka drop out)
C: microtubule associated serine/threonine kinase 2 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
D: microtubule-associated protein 205 (drosophila melanogas... | C |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: pcdhac (homo sapiens) (aka protocadherin alpha constant)
C: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
F: None of the ab... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
B: mast205 (drosophila melanogaster) (aka drop out)
C: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
D: tmem205 (homo sapiens) (aka transmembrane protein 205)
E: transmembrane protein 205 (sus scr... | A |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
B: tmem205 (xenopus tropicalis) (aka transmembrane protein 205)
C: mast 205 (drosophila melanogaster) (aka drop out)
D: transmembrane protein 205 (sus scrofa) (aka transmembrane protein 205)
E: tmem205 (mus musculus) (aka transm... | F |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Options>: A: protocadherin 7 (homo sapiens) (aka protocadherin 7)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
F: None of... | F |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept corresponding to 'protocadherin lkc'. Answer using one of the prov... | <Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: pcdhac (homo sapiens) (aka protocadherin alpha constant)
C: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: protocadherin 10 (homo sapiens) (aka protocadherin 10)
F: Non... | F |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept corresponding to 'pdz protein'. Answer using one of the provided o... | <Options>: A: pdzx (homo sapiens) (aka magi family member, x-linked)
B: pdzd1 (homo sapiens) (aka pdz domain containing 1)
C: pdz domain containing 4 (homo sapiens) (aka pdz domain containing 4)
D: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
E: pdz domain contain... | F |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: daxx (mus musculus) (aka fas death domain-associated protein)
B: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;spx domain-containing protein;uncharacterized protein)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: daxx (homo sapiens) ... | D |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'histone deacetylase ii'. Answer using one of the provided options. | <Options>: A: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
D: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
E: histone deacetylase 2 (xenopus tropicalis) (aka hi... | B |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept corresponding to 'chromatin-associated protein dek'. Answer using one of the provided options. | <Options>: A: dek7 (drosophila melanogaster) (aka eph receptor tyrosine kinase)
B: dek (homo sapiens) (aka dek proto-oncogene)
C: dek (xenopus tropicalis) (aka dek proto-oncogene)
D: dek (danio rerio) (aka dek proto-oncogene)
E: dee (homo sapiens) (aka klk3 upstream enhancer/promoter region)
F: None of the above. | B |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept corresponding to 'daxx'. Answer using one of the provided options. | <Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: dax-1 (homo sapiens) (aka nuclear receptor subfamily 0 group b member 1)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: daxx;spx domain-containing protein;unc... | A |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (danio rerio) (aka death-domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: adx (homo sapiens) (aka ferredoxin 1)
D: daxx (homo sapiens) (aka death domain associated protein)
E: daxx (xenopus tropicalis) (aka death-associated protein 6)
F: None of the above. | D |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: daxx (homo sapiens) (aka death domain associated protein)
D: daxx (danio rerio) (aka death-domain associated protein)
E: daxx (xenopus tropicalis) (aka death-associated protein 6)... | C |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: axed on x (drosophila melanogaster) (aka axed on x)
C: daxx (homo sapiens) (aka death domain associated protein)
D: daxx (drosophila melanogaster) (aka daxx-like protein)
E: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: hyrax (drosophila melanogaster) (aka hyrax)
F: None of the above. | F |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: daxx (homo sapiens) (aka death domain associated protein)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotei... | B |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept correspondi... | <Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
C: daxx (danio rerio) (aka death-domain associated protein)
D: hyrax (drosophila melanogaster) (aka hyrax)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | A |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Options>: A: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: daxx (homo sapiens) (aka death domain associated protein)
D: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: hyrax (drosophila melanogaster... | C |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Options>: A: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
B: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
C: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
D: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
E: hdac2 (homo sapiens) (aka histon... | E |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided ... | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: daxx (homo sapiens) (aka death domain associated protein)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: axed on x (drosophila melanogaster) (aka axed on ... | C |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept corresponding to 'histone deacetylase ii'. Answer using one... | <Options>: A: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
B: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
C: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
D: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
E: histone deacetylase 2 (homo sapien... | E |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (xenopus tropicalis) (aka death-associated protein 6)
C: daxx (homo sapiens) (aka death domain associated protein)
D: daxx (danio rerio) (aka death-domain associated protein)
E: axed on x (drosophila melanogaster) (aka axed on x)
F: None of the above. | C |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: hyrax (drosophila melanogaster) (aka hyrax)
D: daxx (homo sapiens) (aka death domain associated protein)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | D |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept corresponding to 'hdaxx'. Answer using one of the provided options. | <Options>: A: hyrax (drosophila melanogaster) (aka hyrax)
B: adx (homo sapiens) (aka ferredoxin 1)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: daxx (homo sapiens) (aka death domain associated protein)
E: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
F: No... | D |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: separase (candida albicans sc5314) ... | B |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: separase (drosophila melanogaster) (aka separase)
E: homolog of sepa... | F |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separ... | E |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies like 1, separase (bos taurus) (aka... | A |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: separase (drosophila melanogaster) (aka separase)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole bodies like 1, sep... | D |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid s... | A |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle ... | C |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
D: separase (saccharomyces cerevisiae s288c) (aka separase)
E: extra spindle pole bod... | C |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (candida albicans sc5314) (aka separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle ... | A |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: homolog of separase (arabidopsis thaliana) (aka separase)
E: esp1 (homo sapiens) (ext... | E |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept corresponding to 'separase'. Answer u... | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle... | C |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
D: extra spindl... | E |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: separase (drosophila melanoga... | F |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
C: securin-like protein (caenorhabditi... | A |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, s... | C |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chro... | C |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: separin homolog sep-1 (caen... | A |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: separase (candida albicans sc5314) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: separase (sac... | C |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: securin (caenorhabditis elegans) (aka securin)
B: securin (xenopus laevis) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
D: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
E: ptt... | E |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: separase (candida albicans sc5314) (aka separase)
D: separase (dro... | B |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: separase (candida albicans sc5314) (aka separase)
D: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle ... | D |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
C: pttg1 regulator of sister chr... | C |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (candida albicans sc5314) (aka separase)
D: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodi... | E |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: separase (candida albicans sc5314) (aka separase)
D: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
E: extra ... | F |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: separase (candida albicans sc5314) (aka separase)
D: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole... | E |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'securin'. Answer using one of the provided options. | <Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid s... | A |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: separase (candida albicans sc5314) (aka separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka ... | D |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: separase (candida albicans sc5314) (aka separase)
E: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))... | E |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept corresponding to 'separase'. Answer using one of the provided options. | <Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
D: separase (drosophila melanogaster) (aka separase)
E: separase (candida albi... | C |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor c... | D |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
D: cd3 gamma subunit of t-cel... | E |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Options>: A: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
C: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor su... | D |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept corresponding to 'icam-1'. Answer using one ... | <Options>: A: icam4 (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
B: intercellular adhesion molecule 1 (homo sapiens) (aka intercellular adhesion molecule 1)
C: icam5 (homo sapiens) (aka intercellular adhesion molecule 5)
D: cell adhesion molecule 1 (homo sapiens) (aka cell adh... | B |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
B: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
C: interleukin 2 receptor subunit gamma (homo sapiens) (aka interle... | E |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept corresponding to 'cd3 gamma'. Answer using one of the provided options. | <Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
C: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
D: cd3 gamma ... | F |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
C: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
D: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
E... | B |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept corresponding to 'l1 adhesion molecule'. Answer using one of the provided options. | <Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1cam (homo sapiens) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: l1 cel... | C |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
E: l1.1... | C |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
E: l1 cell adhesion molecu... | E |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhes... | D |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
D: ad10 (... | D |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retr... | E |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule... | D |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
C: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: adam30 (homo sapiens) (aka ad... | B |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 cell adhesion molec... | D |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
B: l1.1 (mus musculus) (aka skull morphology 1)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
E: cell adhesion molecule ... | F |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1.1 (mus musculus) (aka skull morphology 1)
C: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: cy... | D |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: lethal (1) l1 (drosophila melanogast... | B |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept corresponding to 'l1'. Answer using one of the provided options. | <Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: l1 cell adhesion molecule (xenopus t... | B |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: l1.1 (mus musc... | D |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Options>: A: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
D: adam30 (homo sapiens) (aka adam metallopept... | A |
<Instruct>: Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', select the correct biomedical concept corresponding to 'adam10'. Answer using one of the provided options. | <Options>: A: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: adam-t... | A |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept corresponding to 'yaf2'. Answer using one of the provided options. | <Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: yaf2 (xenopus tropicalis) (aka yy1 associated factor 2)
C: yaf1 (homo sapiens) (aka histone deacetylase 2)
D: yaf2 (bos taurus) (aka yy1 associated factor 2)
E: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
F: No... | A |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: myc-like oncogen... | A |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
D: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka ... | A |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept corresponding to 'mycn'. Answer using one of the provided options. | <Options>: A: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
C: mycn proto-oncogene, bhlh transcription factor (danio rerio... | D |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept corresponding to 'mycn'. Answer using one of the provided options. | <Options>: A: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
B: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription factor)
C: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription fa... | F |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept corresponding to 'mycl'. Answer using one of the provided options. | <Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: l-myc (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
C: mycs-like (mus musculus) (aka cdna sequence, aa543401)
D: mycl (mus musculus) (aka v-myc avian myelocytomatosis v... | B |
<Instruct>: Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
D: myc (mus musculus)... | A |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept corresponding to 'yaf2'. Answer using one of the provided options. | <Options>: A: yaf2 (xenopus tropicalis) (aka yy1 associated factor 2)
B: yaf1 (homo sapiens) (aka histone deacetylase 2)
C: yaf2 (xenopus laevis) (aka yy1 associated factor 2 s homeolog)
D: yaf2 (bos taurus) (aka yy1 associated factor 2)
E: yaf2 (homo sapiens) (aka yy1 associated factor 2)
F: None of the above. | E |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept corresponding to 'mycn'. Answer using one of the provided options. | <Options>: A: mycn (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription factor)
C: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian ... | A |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept corresponding to 'mycn'. Answer using one of the provided options. | <Options>: A: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
B: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
C: mycn (homo sapiens) (aka mycn proto-oncogene, bhlh transcription ... | C |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept corresponding to 'yaf2'. Answer using one of the provided options. | <Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: yaf1 (homo sapiens) (aka histone deacetylase 2)
C: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
D: yaf2 (sus scrofa) (aka yy1 associated factor 2)
E: yaf2 (xenopus tropicalis) (aka yy1 associated factor 2)
F: No... | A |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
D: v-myc avian myelocytomatosis viral related on... | C |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept corresponding to 'mycn'. Answer using one of the provided options. | <Options>: A: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
C: v-myc avian myelocytomatosis viral oncogene neuroblastoma d... | E |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept corresponding to 'yaf2'. Answer using one of the provided options. | <Options>: A: yaf2 (sus scrofa) (aka yy1 associated factor 2)
B: yaf1 (homo sapiens) (aka histone deacetylase 2)
C: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
D: yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated fact... | E |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.