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<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products. ', select the correct biomedical concept corresponding to 'doublecortin'. Answer using one of the provided options.
<Options>: A: doublecortin (sus scrofa) (aka doublecortin) B: doublecortin domain containing 2 (homo sapiens) (aka doublecortin domain containing 2) C: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2) D: doublecortin (bos taurus) (aka doublecortin) E: dcx (homo sapiens) (aka doublecortin) F: None of the above.
E
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5) B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) C: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) D: lis3 (homo sapiens) (aka tubulin alpha 1a) E: lis6 (homo sapiens) (aka katanin regulatory subunit b1) F: None of the above.
B
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (xenopus tropicalis) (aka doublecortin) B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) C: dcx (mus musculus) (aka doublecortin) D: dcx (rattus norvegicus) (aka doublecortin) E: doublecortin (homo sapiens) (aka doublecortin) F: None of the above.
E
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin) B: doublecortin (xenopus tropicalis) (aka doublecortin) C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) D: dcx (mus musculus) (aka doublecortin) E: doublecortin (rattus norvegicus) (aka doublecortin) F: None of the above.
F
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept corresponding to 'type i lissencephaly'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis6 (homo sapiens) (aka katanin regulatory subunit b1) C: lisch7 (homo sapiens) (aka lipolysis stimulated lipoprotein receptor) D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) E: lis7 (homo sapiens) (aka cyclin dependent kinase 5) F: None of the above.
A
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) C: lis1 (drosophila melanogaster) (aka lissencephaly-1) D: lis7 (homo sapiens) (aka cyclin dependent kinase 5) E: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) F: None of the above.
B
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) B: dcx (homo sapiens) (aka doublecortin) C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) D: dcx (xenopus tropicalis) (aka doublecortin) E: dcx (mus musculus) (aka doublecortin) F: None of the above.
B
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) C: doublecortin (homo sapiens) (aka doublecortin) D: dcx (mus musculus) (aka doublecortin) E: doublecortin (xenopus tropicalis) (aka doublecortin) F: None of the above.
C
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis6 (homo sapiens) (aka katanin regulatory subunit b1) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) E: lis7 (homo sapiens) (aka cyclin dependent kinase 5) F: None of the above.
A
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin) B: dcx (xenopus tropicalis) (aka doublecortin) C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) D: doublecortin (homo sapiens) (aka doublecortin) E: doublecortin (rattus norvegicus) (aka doublecortin) F: None of the above.
D
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a) B: lis6 (homo sapiens) (aka katanin regulatory subunit b1) C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) E: lis-1 (drosophila melanogaster) (aka lissencephaly-1) F: None of the above.
D
<Instruct>: Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: doublecortin (homo sapiens) (aka doublecortin) B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) C: dcx (mus musculus) (aka doublecortin) D: doublecortin (xenopus tropicalis) (aka doublecortin) E: dcx (oryctolagus cuniculus) (aka doublecortin) F: None of the above.
A
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog) B: lis7 (homo sapiens) (aka cyclin dependent kinase 5) C: lis3 (homo sapiens) (aka tubulin alpha 1a) D: lis-1 (drosophila melanogaster) (aka lissencephaly-1) E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) F: None of the above.
E
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin) B: dcx (rattus norvegicus) (aka doublecortin) C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) D: dcx (homo sapiens) (aka doublecortin) E: dcx (xenopus tropicalis) (aka doublecortin) F: None of the above.
D
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (mus musculus) (aka doublecortin) B: dcx (rattus norvegicus) (aka doublecortin) C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) D: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) E: dcx (oryctolagus cuniculus) (aka doublecortin) F: None of the above.
F
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1) B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) C: lis-1 (drosophila melanogaster) (aka lissencephaly-1) D: lis7 (homo sapiens) (aka cyclin dependent kinase 5) E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) F: None of the above.
B
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (mus musculus) (aka doublecortin) B: doublecortin (homo sapiens) (aka doublecortin) C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) E: dcx (oryctolagus cuniculus) (aka doublecortin) F: None of the above.
B
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: doublecortin (xenopus tropicalis) (aka doublecortin) B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) D: dcx (mus musculus) (aka doublecortin) E: dcx (homo sapiens) (aka doublecortin) F: None of the above.
E
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5) B: lis3 (homo sapiens) (aka tubulin alpha 1a) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) E: lis1 (drosophila melanogaster) (aka lissencephaly-1) F: None of the above.
D
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis1 (drosophila melanogaster) (aka lissencephaly-1) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) E: lis3 (homo sapiens) (aka tubulin alpha 1a) F: None of the above.
A
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase) B: dcx (xenopus tropicalis) (aka doublecortin) C: doublecortin (homo sapiens) (aka doublecortin) D: dcx (oryctolagus cuniculus) (aka doublecortin) E: dcx (mus musculus) (aka doublecortin) F: None of the above.
C
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis-1 (drosophila melanogaster) (aka lissencephaly-1) C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) D: lis3 (homo sapiens) (aka tubulin alpha 1a) E: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog) F: None of the above.
A
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: dcx (homo sapiens) (aka doublecortin) B: doublecortin (xenopus tropicalis) (aka doublecortin) C: dcx (oryctolagus cuniculus) (aka doublecortin) D: doublecortin (rattus norvegicus) (aka doublecortin) E: dcx (mus musculus) (aka doublecortin) F: None of the above.
A
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) E: lis7 (homo sapiens) (aka cyclin dependent kinase 5) F: None of the above.
A
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) B: lis3 (homo sapiens) (aka tubulin alpha 1a) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) E: lis7 (homo sapiens) (aka cyclin dependent kinase 5) F: None of the above.
D
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1) B: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) D: lis3 (homo sapiens) (aka tubulin alpha 1a) E: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog) F: None of the above.
F
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept corresponding to 'lis1'. Answer using one of the provided options.
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1) B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1) C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript) D: lis7 (homo sapiens) (aka cyclin dependent kinase 5) E: lis1 (drosophila melanogaster) (aka lissencephaly-1) F: None of the above.
A
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept corresponding to 'dcx'. Answer using one of the provided options.
<Options>: A: doublecortin (rattus norvegicus) (aka doublecortin) B: doublecortin (xenopus tropicalis) (aka doublecortin) C: dcx (homo sapiens) (aka doublecortin) D: dcx (oryctolagus cuniculus) (aka doublecortin) E: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase) F: None of the above.
C
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) C: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) E: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) F: None of the above.
D
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) B: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) D: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) E: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) F: None of the above.
C
<Instruct>: Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) B: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) D: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) E: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) F: None of the above.
A
<Instruct>: Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) C: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) D: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) F: None of the above.
A
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) B: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) C: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) D: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) F: None of the above.
A
<Instruct>: Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) B: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) E: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) F: None of the above.
D
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) C: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) D: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) F: None of the above.
E
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) D: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) F: None of the above.
E
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) C: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) D: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) F: None of the above.
F
<Instruct>: Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) C: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) D: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) E: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2) F: None of the above.
B
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) B: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) F: None of the above.
C
<Instruct>: Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) E: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) F: None of the above.
D
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4) B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) C: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4) D: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2) E: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15) F: None of the above.
B
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical concept corresponding to 'kv4.2'. Answer using one of the provided options.
<Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2) B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2) C: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2) D: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1) E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2) F: None of the above.
E
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'tmprss3'. Answer using one of the provided options.
<Options>: A: tmprss3 (sus scrofa) (aka transmembrane serine protease 3) B: transmembrane serine protease 3 (homo sapiens) (aka transmembrane serine protease 3) C: tmprss3 (xenopus tropicalis) (transmembrane serine protease 3 (xenopus tropicalis)) (aka transmembrane serine protease 3) D: tmprss3 (danio rerio) (aka transmembrane serine protease 3b) E: try3 (homo sapiens) (prss3 pseudogene 3 (homo sapiens)) (aka prss3 pseudogene 3) F: None of the above.
B
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'echos1'. Answer using one of the provided options.
<Options>: A: echos1 (homo sapiens) (aka transmembrane serine protease 3) B: echo virus (serotypes 4, 6, 11, 19) sensitivity (homo sapiens) (aka echo virus (serotypes 4, 6, 11, 19) sensitivity) C: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3) D: entr1 (homo sapiens) (aka endosome associated trafficking regulator 1) E: echos1 (xenopus laevis) (aka transmembrane serine protease 3 l homeolog) F: None of the above.
A
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options.
<Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4) B: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead) C: dfnb9 (homo sapiens) (aka otoferlin) D: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20) E: dfnb10 (homo sapiens) (aka transmembrane serine protease 3) F: None of the above.
E
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept corresponding to 'dfnb8'. Answer using one of the provided options.
<Options>: A: dfna8 (homo sapiens) (aka tectorin alpha) B: dfnb3 (homo sapiens) (aka myosin xva) C: dfn6 (homo sapiens) (aka small muscle protein x-linked) D: dfnb10 (homo sapiens) (aka transmembrane serine protease 3) E: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4) F: None of the above.
D
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options.
<Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4) B: dfnb10 (homo sapiens) (aka transmembrane serine protease 3) C: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40) D: dfnb110 (homo sapiens) (aka cochlin) E: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead) F: None of the above.
B
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept corresponding to 'dfnb10'. Answer using one of the provided options.
<Options>: A: dfnb9 (homo sapiens) (aka otoferlin) B: dfnb110 (homo sapiens) (aka cochlin) C: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20) D: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40) E: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3) F: None of the above.
F
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept corresponding to 'dfnb8'. Answer using one of the provided options.
<Options>: A: dfnb9 (homo sapiens) (aka otoferlin) B: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5) C: dfnb10 (homo sapiens) (aka transmembrane serine protease 3) D: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4) E: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin) F: None of the above.
C
<Instruct>: Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. ', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated) B: fancb (homo sapiens) (aka fa complementation group b) C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated) D: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2) E: palb2 (homo sapiens) (aka partner and localizer of brca2) F: None of the above.
A
<Instruct>: Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated) B: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2) C: fancd2 (homo sapiens) (aka fa complementation group d2) D: fancb (homo sapiens) (aka fa complementation group b) E: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog) F: None of the above.
A
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2) B: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2) C: fancd2 (homo sapiens) (aka fa complementation group d2) D: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated) E: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated) F: None of the above.
D
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2) B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog) C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated) D: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2) E: palb2 (homo sapiens) (aka partner and localizer of brca2) F: None of the above.
F
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept corresponding to 'brca2-associated factor 35'. Answer using one of the provided options.
<Options>: A: acf65 (homo sapiens) (aka apobec1 complementation factor) B: saga complex associated factor 29 (xenopus tropicalis) (aka saga complex associated factor 29) C: chromosome 6 c1orf35 homolog (xenopus tropicalis) (aka chromosome 6 c1orf35 homolog) D: btaf (tbp-associated factor) homolog (caenorhabditis elegans) (aka btaf (tbp-associated factor) homolog) E: formation of mitochondrial complex v assembly factor 1 homolog (xenopus tropicalis) (aka formation of mitochondrial complex v assembly factor 1 homolog) F: None of the above.
F
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) B: braf35 (homo sapiens) (aka high mobility group 20b) C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog) D: braf35 (mus musculus) (aka high mobility group 20b) E: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1) F: None of the above.
B
<Instruct>: Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf25 (homo sapiens) (aka high mobility group 20b) B: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog) C: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) D: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1) E: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog) F: None of the above.
A
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2) B: fancd2 (homo sapiens) (aka fa complementation group d2) C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog) D: fancb (homo sapiens) (aka fa complementation group b) E: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated) F: None of the above.
E
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf2 (homo sapiens) (aka braf pseudogene 1) B: braf25 (homo sapiens) (aka high mobility group 20b) C: braf35 (mus musculus) (aka high mobility group 20b) D: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1) E: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) F: None of the above.
C
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) B: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog) C: braf35 (homo sapiens) (aka high mobility group 20b) D: braf2 (homo sapiens) (aka braf pseudogene 1) E: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog) F: None of the above.
F
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) B: braf35 (mus musculus) (aka high mobility group 20b) C: braf25 (homo sapiens) (aka high mobility group 20b) D: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1) E: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog) F: None of the above.
C
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated) B: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2) C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated) D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog) E: fancd2 (homo sapiens) (aka fa complementation group d2) F: None of the above.
A
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept corresponding to 'brca2'. Answer using one of the provided options.
<Options>: A: fancb (homo sapiens) (aka fa complementation group b) B: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated) C: palb2 (homo sapiens) (aka partner and localizer of brca2) D: brca2 (homo sapiens) (aka brca2 dna repair associated) E: fancd2 (homo sapiens) (aka fa complementation group d2) F: None of the above.
D
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept corresponding to 'braf35'. Answer using one of the provided options.
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b) B: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase) C: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1) D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog) E: braf35 (homo sapiens) (aka high mobility group 20b) F: None of the above.
E
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: nkx6b (homo sapiens) (aka nk6 homeobox 2) B: nkx3b (homo sapiens) (aka nk3 homeobox 2) C: nkx6a (homo sapiens) (aka nk6 homeobox 1) D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) E: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) F: None of the above.
A
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options.
<Options>: A: nkx6-2 (mus musculus) (aka nk6 homeobox 2) B: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2) C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) E: nkx6-3 (homo sapiens) (aka nk6 homeobox 3) F: None of the above.
A
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept corresponding to 'gtx'. Answer using one of the provided options.
<Options>: A: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevis)) (aka hematopoietically expressed homeobox s homeolog) B: gtx (mus musculus) (aka nk6 homeobox 2) C: gtx (drosophila melanogaster) (aka syntaxin 18) D: gtx (homo sapiens) (aka nk6 homeobox 2) E: gtx (xenopus tropicalis) (aka nk6 homeobox 2) F: None of the above.
B
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2) B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) D: nkx6.2 (homo sapiens) (aka nk6 homeobox 2) E: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) F: None of the above.
D
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) C: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2) D: nkx6.2 (homo sapiens) (aka nk6 homeobox 2) E: nkx6a (homo sapiens) (aka nk6 homeobox 1) F: None of the above.
D
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options.
<Options>: A: nkx6-3 (homo sapiens) (aka nk6 homeobox 3) B: nkx6-2 (mus musculus) (aka nk6 homeobox 2) C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) E: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2) F: None of the above.
B
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept corresponding to 'nkx6-2'. Answer using one of the provided options.
<Options>: A: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2) B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog) D: nkx6b (homo sapiens) (aka nk6 homeobox 2) E: nkx5-2 (homo sapiens) (aka h6 family homeobox 2) F: None of the above.
F
<Instruct>: Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) B: nkx3b (homo sapiens) (aka nk3 homeobox 2) C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) D: nkx6-2 (homo sapiens) (aka nk6 homeobox 2) E: nkx6a (homo sapiens) (aka nk6 homeobox 1) F: None of the above.
D
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2) B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) C: nkx6-2 (homo sapiens) (aka nk6 homeobox 2) D: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) E: nkx3b (homo sapiens) (aka nk3 homeobox 2) F: None of the above.
C
<Instruct>: Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', select the correct biomedical concept corresponding to 'nkx6b'. Answer using one of the provided options.
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog) B: nkx6a (homo sapiens) (aka nk6 homeobox 1) C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog) D: nkx3b (homo sapiens) (aka nk3 homeobox 2) E: nkx6.2 (homo sapiens) (aka nk6 homeobox 2) F: None of the above.
E
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', select the correct biomedical concept corresponding to 'cd58'. Answer using one of the provided options.
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1) B: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group)) C: cd58 (homo sapiens) (aka cd58 molecule) D: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) E: cd5 (homo sapiens) (aka cd5 molecule) F: None of the above.
C
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd22 molecule (homo sapiens) (aka cd22 molecule) B: cd2 molecule (homo sapiens) (aka cd2 molecule) C: cd2 locus control region (homo sapiens) (aka cd2 locus control region) D: cd228 (homo sapiens) (aka melanotransferrin) E: cd21 (homo sapiens) (aka complement c3d receptor 2) F: None of the above.
B
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd4'. Answer using one of the provided options.
<Options>: A: gp4 (homo sapiens) (aka cd36 molecule (cd36 blood group)) B: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4) C: cd4 (homo sapiens) (aka cd4 molecule) D: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4) E: integrin subunit alpha 4 (homo sapiens) (aka integrin subunit alpha 4) F: None of the above.
C
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd58'. Answer using one of the provided options.
<Options>: A: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1) B: cd54 (homo sapiens) (aka intercellular adhesion molecule 1) C: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group)) D: cd5 molecule (homo sapiens) (aka cd5 molecule) E: cd58 molecule (homo sapiens) (aka cd58 molecule) F: None of the above.
E
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule) B: cd21 (homo sapiens) (aka complement c3d receptor 2) C: cd2 locus control region (homo sapiens) (aka cd2 locus control region) D: cd2 (bos taurus) (aka cd2 molecule) E: cd2 molecule (homo sapiens) (aka cd2 molecule) F: None of the above.
E
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'fos'. Answer using one of the provided options.
<Options>: A: fos (mus musculus) (aka fbj osteosarcoma oncogene) B: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit) C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit) D: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog) E: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit) F: None of the above.
B
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options.
<Options>: A: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit) B: jun (mus musculus) (aka jun proto-oncogene) C: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit) D: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit) E: juno (homo sapiens) (aka izumo1 receptor, juno) F: None of the above.
A
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'jun'. Answer using one of the provided options.
<Options>: A: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit) B: juno (homo sapiens) (aka izumo1 receptor, juno) C: jun (mus musculus) (aka jun proto-oncogene) D: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit) E: None of the above.
E
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options.
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3) B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2) C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2) D: il-2 (homo sapiens) (aka interleukin 2) E: il22 (homo sapiens) (aka interleukin 22) F: None of the above.
D
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept corresponding to 'c-fos'. Answer using one of the provided options.
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog) B: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit) C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit) D: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit) E: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog) F: None of the above.
D
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule) B: cd2 (homo sapiens) (aka cd2 molecule) C: cd2 (bos taurus) (aka cd2 molecule) D: cd2 locus control region (homo sapiens) (aka cd2 locus control region) E: cd22 (homo sapiens) (aka cd22 molecule) F: None of the above.
B
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options.
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2) B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2) C: il22 (homo sapiens) (aka interleukin 22) D: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2) E: interleukin 2 (homo sapiens) (aka interleukin 2) F: None of the above.
E
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule) B: cd228 (homo sapiens) (aka melanotransferrin) C: cd2 (homo sapiens) (aka cd2 molecule) D: cd2 (gallus gallus) (aka cd2 molecule) E: cd21 (homo sapiens) (aka complement c3d receptor 2) F: None of the above.
C
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd2 molecule (homo sapiens) (aka cd2 molecule) B: cd22 molecule (homo sapiens) (aka cd22 molecule) C: cd2 locus control region (homo sapiens) (aka cd2 locus control region) D: cd2 molecule (bos taurus) (aka cd2 molecule) E: cd21 (homo sapiens) (aka complement c3d receptor 2) F: None of the above.
A
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule) B: cd2 locus control region (homo sapiens) (aka cd2 locus control region) C: cd22 (homo sapiens) (aka cd22 molecule) D: cd21 (homo sapiens) (aka complement c3d receptor 2) E: cd2 (gallus gallus) (aka cd2 molecule) F: None of the above.
A
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept corresponding to 'cd2'. Answer using one of the provided options.
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region) B: cd2 molecule (bos taurus) (aka cd2 molecule) C: cd21 (homo sapiens) (aka complement c3d receptor 2) D: cd228 (homo sapiens) (aka melanotransferrin) E: cd2 molecule (homo sapiens) (aka cd2 molecule) F: None of the above.
E
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. ', select the correct biomedical concept corresponding to 'mammalian target of rapamycin'. Answer using one of the provided options.
<Options>: A: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase) B: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase) C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog) D: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator) E: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin) F: None of the above.
F
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. ', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options.
<Options>: A: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase) B: mtor (mus musculus) (aka mechanistic target of rapamycin kinase) C: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase) D: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin) E: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator) F: None of the above.
F
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. ', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options.
<Options>: A: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase) B: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog) C: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin) D: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase) E: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase) F: None of the above.
F
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept corresponding to 'alpha1 ampk'. Answer using one of the provided options.
<Options>: A: alpha kinase 1 (homo sapiens) (aka alpha kinase 1) B: prkaca (homo sapiens) (protein kinase camp-activated catalytic subunit alpha (homo sapiens)) (aka protein kinase camp-activated catalytic subunit alpha) C: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 2) D: ampka1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1) E: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit) F: None of the above.
F
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept corresponding to 'alpha2 ampk'. Answer using one of the provided options.
<Options>: A: alpha kinase 2 (homo sapiens) (aka alpha kinase 2) B: ampk alpha 1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1) C: prkaa2 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2) D: prkar2a (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit alpha) E: ampkalpha2 (mus musculus) (aka protein kinase, amp-activated, alpha 2 catalytic subunit) F: None of the above.
F
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept corresponding to 'mammalian target of rapamycin'. Answer using one of the provided options.
<Options>: A: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase) B: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog) C: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase) D: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase) E: mechanistic target of rapamycin (drosophila melanogaster) (aka mechanistic target of rapamycin) F: None of the above.
F
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options.
<Options>: A: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase) B: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator) C: mtor (mus musculus) (aka mechanistic target of rapamycin kinase) D: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase) E: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog) F: None of the above.
F
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept corresponding to 'mtor'. Answer using one of the provided options.
<Options>: A: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase) B: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin) C: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase) D: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator) E: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase) F: None of the above.
F
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept corresponding to 'ribosomal protein s6 kinase'. Answer using one of the provided options.
<Options>: A: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1) B: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1) C: s6kbeta (homo sapiens) (aka ribosomal protein s6 kinase b2) D: rps6ka6 (homo sapiens) (aka ribosomal protein s6 kinase a6) E: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6) F: None of the above.
F
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept corresponding to 'eif4e'. Answer using one of the provided options.
<Options>: A: eif4e (xenopus laevis) (eukaryotic translation initiation factor 4e l homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4e l homeolog) B: eukaryotic translation initiation factor 4e (xenopus laevis) (aka eukaryotic translation initiation factor 4e) C: eukaryotic translation initiation factor 4e homologous protein (drosophila melanogaster) (aka eukaryotic translation initiation factor 4e homologous protein) D: eif4e (xenopus tropicalis) (eukaryotic translation initiation factor 4e (xenopus tropicalis)) (aka eukaryotic translation initiation factor 4e) E: eif4e (homo sapiens) (aka eukaryotic translation initiation factor 4e) F: None of the above.
F
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept corresponding to 'eif4g'. Answer using one of the provided options.
<Options>: A: eif4g (homo sapiens) (aka eukaryotic translation initiation factor 4 gamma 1) B: eif4g (xenopus laevis) (eukaryotic translation initiation factor 4 gamma, 1 s homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4 gamma, 1 s homeolog) C: eif4g (drosophila melanogaster) (eukaryotic translation initiation factor 4g2 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4g2) D: eif4g (drosophila melanogaster) (eukaryotic translation initiation factor 4g1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4g1) E: eif4g (xenopus tropicalis) (aka eukaryotic translation initiation factor 4 gamma, 1) F: None of the above.
F