instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
D: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
E: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
F: None of the above. | A |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
D: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
E: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
F: None of the above. | F |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
D: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
E: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
F: None of the above. | D |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept corresponding to 'myc'. Answer using one of the provided options. | <Options>: A: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
D: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
E: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
F: None of the above. | A |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the correct biomedical concept corresponding to 'keratinocyte growth factor receptor'. Answer using one of the provided options. | <Options>: A: trkb (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: fibroblast growth factor receptor 2 (homo sapiens) (aka fibroblast growth factor receptor 2)
D: bfgfr (homo sapiens) (aka fibroblast growth factor receptor 1)
E: None of the above. | C |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the correct biomedical concept corresponding to 'bek'. Answer using one of the provided options. | <Options>: A: bek (xenopus tropicalis) (aka fibroblast growth factor receptor 2)
B: blk (bos taurus) (aka blk proto-oncogene, src family tyrosine kinase)
C: rabepk (bos taurus) (aka rab9 effector protein with kelch motifs)
D: bek (mus musculus) (aka fibroblast growth factor receptor 2)
E: bek (homo sapiens) (aka fibroblast growth factor receptor 2)
F: None of the above. | E |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the correct biomedical concept corresponding to 'fibroblast growth factor receptor 2'. Answer using one of the provided options. | <Options>: A: fibroblast growth factor receptor 2 (homo sapiens) (aka fibroblast growth factor receptor 2)
B: fibroblast growth factor receptor 2 (sus scrofa) (aka fibroblast growth factor receptor 2)
C: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
D: flt2 (homo sapiens) (aka fibroblast growth factor receptor 1)
E: None of the above. | A |
<Instruct>: Given the context 'Both serine and tyrosine phosphatase activities were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein.', select the correct biomedical concept corresponding to 'vh1-related (vhr) human protein'. Answer using one of the provided options. | <Options>: A: hshvrp1 (homo sapiens) (aka transmembrane protein 266)
B: vhr (homo sapiens) (aka dual specificity phosphatase 3)
C: vhp (homo sapiens) (aka dual specificity phosphatase 28)
D: vhnf1 (homo sapiens) (aka hnf1 homeobox b)
E: vh (homo sapiens) (solute carrier family 7 member 4 (homo sapiens)) (aka solute carrier family 7 member 4)
F: None of the above. | B |
<Instruct>: Given the context 'These properties suggest that VHR is capable of regulating intracellular events mediated by both tyrosine and serine phosphorylation.', select the correct biomedical concept corresponding to 'vhr'. Answer using one of the provided options. | <Options>: A: vhr2 (saccharomyces cerevisiae s288c) (aka vhr2p)
B: vhr (mus musculus) (aka dual specificity phosphatase 3 (vaccinia virus phosphatase vh1-related))
C: vh5 (homo sapiens) (aka immunoglobulin heavy variable 5-78 (pseudogene))
D: vho (homo sapiens) (aka growth differentiation factor 11)
E: vhr (homo sapiens) (aka dual specificity phosphatase 3)
F: None of the above. | E |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept corresponding to 'ah receptor nuclear translocator'. Answer using one of the provided options. | <Options>: A: aryl hydrocarbon receptor nuclear translocator (xenopus tropicalis) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator homolog (caenorhabditis elegans) (aka aryl hydrocarbon receptor nuclear translocator homolog)
C: aryl hydrocarbon receptor (homo sapiens) (aka aryl hydrocarbon receptor)
D: aryl hydrocarbon receptor nuclear translocator (rattus norvegicus) (aka aryl hydrocarbon receptor nuclear translocator)
E: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | E |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept corresponding to 'arnt'. Answer using one of the provided options. | <Options>: A: arno3 (homo sapiens) (aka cytohesin 3)
B: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
C: arnt (drosophila melanogaster) (aka tango)
D: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
E: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | E |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept corresponding to 'ah receptor'. Answer using one of the provided options. | <Options>: A: ahr (homo sapiens) (aka aryl hydrocarbon receptor)
B: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
C: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
D: ahh (homo sapiens) (aryl hydrocarbon receptor repressor (homo sapiens)) (aka aryl hydrocarbon receptor repressor)
E: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
F: None of the above. | A |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept corresponding to 'ah receptor'. Answer using one of the provided options. | <Options>: A: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
B: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
C: ahrr (homo sapiens) (aryl hydrocarbon receptor repressor (homo sapiens)) (aka aryl hydrocarbon receptor repressor)
D: aryl hydrocarbon receptor (rattus norvegicus) (aka aryl hydrocarbon receptor)
E: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | F |
<Instruct>: Given the context 'The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects.', select the correct biomedical concept corresponding to 'ah (dioxin) receptor'. Answer using one of the provided options. | <Options>: A: ahrr1 (danio rerio) (aka aryl-hydrocarbon receptor repressor a)
B: ahr (homo sapiens) (aka aryl hydrocarbon receptor)
C: ahrr (homo sapiens) (aryl hydrocarbon receptor repressor (homo sapiens)) (aka aryl hydrocarbon receptor repressor)
D: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
E: aryl hydrocarbon receptor nuclear translocator homolog (caenorhabditis elegans) (aka aryl hydrocarbon receptor nuclear translocator homolog)
F: None of the above. | B |
<Instruct>: Given the context 'The ligand-bound receptor activates Cyp 1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs).', select the correct biomedical concept corresponding to 'cyp 1a1'. Answer using one of the provided options. | <Options>: A: cyp17a1 (homo sapiens) (aka cytochrome p450 family 17 subfamily a member 1)
B: cytochrome p450 1a1 (oryctolagus cuniculus) (aka cytochrome p450 1a1)
C: cyp1alpha (homo sapiens) (aka cytochrome p450 family 27 subfamily b member 1)
D: cyp1 (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
E: cytochrome p450 family 1 subfamily b member 1 (homo sapiens) (aka cytochrome p450 family 1 subfamily b member 1)
F: None of the above. | D |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept corresponding to 'ah receptor nuclear translocator'. Answer using one of the provided options. | <Options>: A: aryl hydrocarbon receptor nuclear translocator (gallus gallus) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator 2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
C: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
D: aryl hydrocarbon receptor nuclear translocator (xenopus tropicalis) (aka aryl hydrocarbon receptor nuclear translocator)
E: aryl hydrocarbon receptor nuclear translocator (rattus norvegicus) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | C |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept corresponding to 'arnt'. Answer using one of the provided options. | <Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
C: arnt (drosophila melanogaster) (aka tango)
D: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
E: arno (homo sapiens) (aka cytohesin 2)
F: None of the above. | D |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept corresponding to 'ah receptor'. Answer using one of the provided options. | <Options>: A: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: aryl hydrocarbon receptor repressor (homo sapiens) (aka aryl hydrocarbon receptor repressor)
C: ahr (homo sapiens) (aka aryl hydrocarbon receptor)
D: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
E: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | C |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept corresponding to 'arnt'. Answer using one of the provided options. | <Options>: A: arno (homo sapiens) (aka cytohesin 2)
B: arnt (drosophila melanogaster) (aka tango)
C: basic helix-loop-helix arnt like 1 (xenopus tropicalis) (aka basic helix-loop-helix arnt like 1)
D: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
E: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
F: None of the above. | D |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept corresponding to 'ah receptor'. Answer using one of the provided options. | <Options>: A: aryl hydrocarbon receptor (rattus norvegicus) (aka aryl hydrocarbon receptor)
B: ahhr (homo sapiens) (aka aryl hydrocarbon receptor repressor)
C: aryl hydrocarbon receptor (homo sapiens) (aka aryl hydrocarbon receptor)
D: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
E: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
F: None of the above. | C |
<Instruct>: Given the context 'Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand.', select the correct biomedical concept corresponding to 'arnt'. Answer using one of the provided options. | <Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: basic helix-loop-helix arnt like 1 (xenopus tropicalis) (aka basic helix-loop-helix arnt like 1)
C: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
D: arno (homo sapiens) (aka cytohesin 2)
E: basic helix-loop-helix arnt like 1 (homo sapiens) (aka basic helix-loop-helix arnt like 1)
F: None of the above. | C |
<Instruct>: Given the context 'Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.', select the correct biomedical concept corresponding to 'arnt'. Answer using one of the provided options. | <Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arnt (drosophila melanogaster) (aka tango)
C: arno (homo sapiens) (aka cytohesin 2)
D: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
E: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
F: None of the above. | D |
<Instruct>: Given the context 'Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
', select the correct biomedical concept corresponding to 'saf-a'. Answer using one of the provided options. | <Options>: A: saf-b (homo sapiens) (aka scaffold attachment factor b)
B: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
C: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
D: saf-a (drosophila melanogaster) (aka uncharacterized protein)
E: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
F: None of the above. | C |
<Instruct>: Given the context 'Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
', select the correct biomedical concept corresponding to 'saf-a'. Answer using one of the provided options. | <Options>: A: saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
B: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
C: saf (homo sapiens) (aka fas antisense rna 1)
D: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
E: saf-a (drosophila melanogaster) (aka uncharacterized protein)
F: None of the above. | F |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept corresponding to 'scaffold attachment region'. Answer using one of the provided options. | <Options>: A: steroid receptor associated and regulated protein (sus scrofa) (aka steroid receptor associated and regulated protein)
B: clk4 associating serine/arginine rich protein (sus scrofa) (aka clk4 associating serine/arginine rich protein)
C: clk4 associating serine/arginine rich protein (bos taurus) (aka clk4 associating serine/arginine rich protein)
D: clk4-associating serine/arginine rich protein (mus musculus) (aka clk4-associating serine/arginine rich protein)
E: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
F: None of the above. | F |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept corresponding to 'sar'. Answer using one of the provided options. | <Options>: A: sar1 (arabidopsis thaliana) (suppressor of auxin resistance1 (arabidopsis thaliana)) (aka suppressor of auxin resistance1)
B: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
C: sar (mus musculus) (sarcosinemia autosomal recessive (mus musculus)) (aka sarcosinemia autosomal recessive)
D: sarp (homo sapiens) (aka ankyrin repeat domain 42)
E: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
F: None of the above. | F |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept corresponding to 'saf-a'. Answer using one of the provided options. | <Options>: A: saf (homo sapiens) (aka fas antisense rna 1)
B: saf-a (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: saf-b (homo sapiens) (aka scaffold attachment factor b)
D: saf-a (drosophila melanogaster) (aka uncharacterized protein)
E: scf ubiquitin ligase complex subunit saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
F: None of the above. | B |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept corresponding to 'scaffold attachment factor a'. Answer using one of the provided options. | <Options>: A: uv stimulated scaffold protein a (xenopus tropicalis) (aka uv stimulated scaffold protein a)
B: chromatin assembly factor 1 subunit a (sus scrofa) (aka chromatin assembly factor 1 subunit a)
C: nucleosome assembly factor asf1 (saccharomyces cerevisiae s288c) (aka nucleosome assembly factor asf1)
D: saf-a (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: uv-stimulated scaffold protein a homolog (caenorhabditis elegans) (aka uv-stimulated scaffold protein a homolog)
F: None of the above. | D |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept corresponding to 'sar'. Answer using one of the provided options. | <Options>: A: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
B: sar (mus musculus) (sarcosinemia autosomal recessive (mus musculus)) (aka sarcosinemia autosomal recessive)
C: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
D: sar1a (homo sapiens) (aka secretion associated ras related gtpase 1a)
E: small regulatory polypeptide of amino acid response (homo sapiens) (aka small regulatory polypeptide of amino acid response)
F: None of the above. | F |
<Instruct>: Given the context 'SAF-A is an abundant nuclear protein and a constituent of the nuclear matrix and scaffold.', select the correct biomedical concept corresponding to 'saf-a'. Answer using one of the provided options. | <Options>: A: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: saf-b (homo sapiens) (aka scaffold attachment factor b)
C: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
D: scf ubiquitin ligase complex subunit saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
E: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
F: None of the above. | E |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept corresponding to 'saf-a'. Answer using one of the provided options. | <Options>: A: saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
B: saf (homo sapiens) (aka fas antisense rna 1)
C: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
D: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
E: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
F: None of the above. | C |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept corresponding to 'sar'. Answer using one of the provided options. | <Options>: A: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
B: sarp (homo sapiens) (aka ankyrin repeat domain 42)
C: sar1 (arabidopsis thaliana) (suppressor of auxin resistance1 (arabidopsis thaliana)) (aka suppressor of auxin resistance1)
D: saraf (homo sapiens) (aka store-operated calcium entry associated regulatory factor)
E: sar (mus musculus) (sarcosinemia autosomal recessive (mus musculus)) (aka sarcosinemia autosomal recessive)
F: None of the above. | F |
<Instruct>: Given the context 'Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.
', select the correct biomedical concept corresponding to 'udp-glcnac:gal beta 1-3-galnac-r (glcnac to galnac) beta 1-6glcnac transferase'. Answer using one of the provided options. | <Options>: A: galnact (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltransferase 1)
B: galnt2 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 2)
C: galnt1 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 1)
D: c2gnt-l (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
E: galnact16 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 16)
F: None of the above. | D |
<Instruct>: Given the context 'A cDNA encoding UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase (EC 2.4.1.102), which forms critical branches in O-glycans, has been isolated by an expression cloning approach using Chinese hamster ovary (CHO) cells.', select the correct biomedical concept corresponding to 'udp-glcnac:gal beta 1-3galnac-r (glcnac to galnac) beta 1-6glcnac transferase'. Answer using one of the provided options. | <Options>: A: c2glcnact (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: galnt2 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 2)
D: galnact2 (homo sapiens) (aka chondroitin sulfate n-acetylgalactosaminyltransferase 2)
E: galnt1 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 1)
F: None of the above. | A |
<Instruct>: Given the context 'A cDNA encoding UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase (EC 2.4.1.102), which forms critical branches in O-glycans, has been isolated by an expression cloning approach using Chinese hamster ovary (CHO) cells.', select the correct biomedical concept corresponding to 'udp-glcnac:gal beta 1-3galnac-r (glcnac to galnac) beta 1-6glcnac transferase'. Answer using one of the provided options. | <Options>: A: galnact (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltransferase 1)
B: galnact6 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 6)
C: galnact2 (homo sapiens) (aka chondroitin sulfate n-acetylgalactosaminyltransferase 2)
D: galnt1 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 1)
E: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
F: None of the above. | F |
<Instruct>: Given the context 'Because the antibody used was found to detect most efficiently the oligosaccharide products attached to leukosialin, the CHO cells were also stably transfected with leukosialin cDNA.', select the correct biomedical concept corresponding to 'leukosialin'. Answer using one of the provided options. | <Options>: A: sialophorin (sus scrofa) (aka sialophorin)
B: sialin (homo sapiens) (aka solute carrier family 17 member 5)
C: spn (homo sapiens) (sialophorin (homo sapiens)) (aka sialophorin)
D: granulysin (homo sapiens) (aka granulysin)
E: integrin binding sialoprotein (homo sapiens) (aka integrin binding sialoprotein)
F: None of the above. | C |
<Instruct>: Given the context 'Because the antibody used was found to detect most efficiently the oligosaccharide products attached to leukosialin, the CHO cells were also stably transfected with leukosialin cDNA.', select the correct biomedical concept corresponding to 'leukosialin'. Answer using one of the provided options. | <Options>: A: integrin binding sialoprotein (homo sapiens) (aka integrin binding sialoprotein)
B: sialophorin (homo sapiens) (aka sialophorin)
C: spn (xenopus tropicalis) (sialophorin (xenopus tropicalis)) (aka sialophorin)
D: sialin (homo sapiens) (aka solute carrier family 17 member 5)
E: galn (homo sapiens) (aka galanin and gmap prepropeptide)
F: None of the above. | B |
<Instruct>: Given the context 'The expression of the presumed catalytic domain as a fusion protein with the IgG binding domain of protein A enabled us to demonstrate unequivocally that the cDNA encodes the core 2 beta-1,6-N-acetylglucosaminyltransferase, the enzyme responsible for the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures.', select the correct biomedical concept corresponding to 'core 2 beta-1,6-n-acetylglucosaminyltransferase'. Answer using one of the provided options. | <Options>: A: alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase)
B: c2gnt2 (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 3, mucin type)
C: glucosaminyl (n-acetyl) transferase 1, core 2 (mus musculus) (aka glucosaminyl (n-acetyl) transferase 1, core 2)
D: b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog;glyco_trans_2-like domain-containing protein (caenorhabditis elegans) (aka b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog;glyco_trans_2-like domain-containing protein)
E: c2gnt (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
F: None of the above. | E |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterations in target tissue gene expression.', select the correct biomedical concept corresponding to 'tumor necrosis factor-alpha'. Answer using one of the provided options. | <Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: tnfa (homo sapiens) (aka tumor necrosis factor)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
F: None of the above. | C |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterations in target tissue gene expression.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | C |
<Instruct>: Given the context 'We have used the technique of differential hybridization to identify several primary response genes induced by TNF in human umbilical vein endothelial (HUVE) cells, a cell type that is profoundly activated by cytokine treatment.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnfa (homo sapiens) (aka tumor necrosis factor)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
F: None of the above. | B |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
C: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: cp94 (homo sapiens) (aka beaded filament structural protein 1)
F: None of the above. | A |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: tnfa (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnfb (homo sapiens) (aka lymphotoxin alpha)
F: None of the above. | C |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept corresponding to 'il-1 beta'. Answer using one of the provided options. | <Options>: A: il1-beta (homo sapiens) (aka interleukin 1 beta)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: ifnb1 (homo sapiens) (aka interferon beta 1)
D: None of the above. | A |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: rp94 (homo sapiens) (aka spermatogenesis associated 7)
D: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
E: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
F: None of the above. | B |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
B: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
C: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
D: rp94 (homo sapiens) (aka spermatogenesis associated 7)
E: cp94 (homo sapiens) (aka beaded filament structural protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: tnf (homo sapiens) (aka tumor necrosis factor)
F: None of the above. | E |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
F: None of the above. | D |
<Instruct>: Given the context 'Further, B94 is shown to be a single copy gene that is evolutionarily conserved.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
B: rp94 (homo sapiens) (aka spermatogenesis associated 7)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
E: cp94 (homo sapiens) (aka beaded filament structural protein 1)
F: None of the above. | C |
<Instruct>: Given the context 'Developmental regulation occurs most prominently in mouse embryonic liver and kidney, and a second smaller form of B94 transcript is detected in the placenta and testes.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
E: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
F: None of the above. | A |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: p94 (homo sapiens) (aka calpain 3)
B: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
C: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
F: None of the above. | D |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnfa (homo sapiens) (aka tumor necrosis factor)
F: None of the above. | E |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | C |
<Instruct>: Given the context 'Sequence analysis of the B94 cDNA reveals an open reading frame encoding a 73-kDa polypeptide that has no homology to any known protein.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
E: b94 (homo sapiens) (aka tnf alpha induced protein 2)
F: None of the above. | E |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: rp94 (homo sapiens) (aka spermatogenesis associated 7)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
D: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
E: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
F: None of the above. | B |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
B: p94 (homo sapiens) (aka calpain 3)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: rp94 (homo sapiens) (aka spermatogenesis associated 7)
E: cp94 (homo sapiens) (aka beaded filament structural protein 1)
F: None of the above. | C |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept corresponding to 'b94'. Answer using one of the provided options. | <Options>: A: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
B: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
C: cp94 (homo sapiens) (aka beaded filament structural protein 1)
D: p94 (homo sapiens) (aka calpain 3)
E: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
F: None of the above. | F |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept corresponding to 'tnf'. Answer using one of the provided options. | <Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnfc (homo sapiens) (aka lymphotoxin beta)
E: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
F: None of the above. | A |
<Instruct>: Given the context 'A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung and found to be present on the surface of endothelial cells where it mediates the binding of AGEs (receptor for advanced glycosylation end product or RAGE).', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage-1 (xenopus tropicalis) (aka mok protein kinase)
B: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
C: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
D: rage (gallus gallus) (aka mok protein kinase)
E: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
F: None of the above. | C |
<Instruct>: Given the context 'Using an oligonucleotide probe based on the amino-terminal sequence of RAGE, an apparently full-length cDNA of 1.5 kilobases was isolated from a bovine lung cDNA library.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: en-rage (bos taurus) (aka s100 calcium binding protein a12)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
D: rage1 (homo sapiens) (aka mok protein kinase)
E: rage (gallus gallus) (aka mok protein kinase)
F: None of the above. | B |
<Instruct>: Given the context 'A partial clone encoding the human counterpart of RAGE, isolated from a human lung library, was found to be approximately 90% homologous to the bovine molecule.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
C: en-rage (bos taurus) (aka s100 calcium binding protein a12)
D: rage1 (homo sapiens) (aka mok protein kinase)
E: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
F: None of the above. | B |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage1 (homo sapiens) (aka mok protein kinase)
B: rage-1 (xenopus tropicalis) (aka mok protein kinase)
C: rage (xenopus laevis) (aka mok protein kinase l homeolog)
D: en-rage (bos taurus) (aka s100 calcium binding protein a12)
E: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
F: None of the above. | E |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
D: rage-1 (homo sapiens) (aka mok protein kinase)
E: rage-1 (xenopus tropicalis) (aka mok protein kinase)
F: None of the above. | C |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedical concept corresponding to 'muc 18'. Answer using one of the provided options. | <Options>: A: ck-18 (homo sapiens) (aka keratin 18)
B: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
C: muc-15 (homo sapiens) (aka mucin 15, cell surface associated)
D: muc8 (homo sapiens) (aka mucin 8)
E: mucin-18 (gallus gallus) (aka melanoma cell adhesion molecule)
F: None of the above. | B |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedical concept corresponding to 'ncam'. Answer using one of the provided options. | <Options>: A: ncam-l1 (mus musculus) (aka l1 cell adhesion molecule)
B: ncam-1 (caenorhabditis elegans) (aka ncam (neural cell adhesion molecule) homolog)
C: ncam (homo sapiens) (aka neural cell adhesion molecule 1)
D: ncam-c (rattus norvegicus) (aka neural cell adhesion molecule 1)
E: ncam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
F: None of the above. | C |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedical concept corresponding to 'cd20'. Answer using one of the provided options. | <Options>: A: cd20 (homo sapiens) (membrane spanning 4-domains a1 (homo sapiens)) (aka membrane spanning 4-domains a1)
B: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
C: cd20l2 (homo sapiens) (aka membrane spanning 4-domains a5)
D: cd20 (rattus norvegicus) (aka membrane spanning 4-domains a1)
E: cd20 (bos taurus) (aka membrane spanning 4-domains a1)
F: None of the above. | A |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage (gallus gallus) (aka mok protein kinase)
B: rage-1 (homo sapiens) (aka mok protein kinase)
C: rage (xenopus laevis) (aka mok protein kinase l homeolog)
D: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
E: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
F: None of the above. | D |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage (gallus gallus) (aka mok protein kinase)
B: en-rage (bos taurus) (aka s100 calcium binding protein a12)
C: rage-1 (xenopus tropicalis) (aka mok protein kinase)
D: rage (xenopus laevis) (aka mok protein kinase l homeolog)
E: rage-1 (homo sapiens) (aka mok protein kinase)
F: None of the above. | F |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
D: rage (gallus gallus) (aka mok protein kinase)
E: rage-1 (xenopus tropicalis) (aka mok protein kinase)
F: None of the above. | A |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
D: en-rage (bos taurus) (aka s100 calcium binding protein a12)
E: rage-1 (xenopus tropicalis) (aka mok protein kinase)
F: None of the above. | A |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: en-rage (bos taurus) (aka s100 calcium binding protein a12)
B: rage-1 (xenopus tropicalis) (aka mok protein kinase)
C: rage (xenopus laevis) (aka mok protein kinase l homeolog)
D: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
E: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
F: None of the above. | E |
<Instruct>: Given the context 'These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins.', select the correct biomedical concept corresponding to 'rage'. Answer using one of the provided options. | <Options>: A: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
B: rage (gallus gallus) (aka mok protein kinase)
C: rage (xenopus laevis) (aka mok protein kinase l homeolog)
D: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
E: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
F: None of the above. | E |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept corresponding to 'cd59'. Answer using one of the provided options. | <Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: cd5 (homo sapiens) (aka cd5 molecule)
D: cd58 (homo sapiens) (aka cd58 molecule)
E: cd51 (homo sapiens) (aka integrin subunit alpha v)
F: None of the above. | B |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept corresponding to 'ly-6'. Answer using one of the provided options. | <Options>: A: cd6 molecule (homo sapiens) (aka cd6 molecule)
B: lir-6 (homo sapiens) (aka leukocyte immunoglobulin like receptor a1)
C: ly5 (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
D: lymphocyte antigen 6 family member s (homo sapiens) (aka lymphocyte antigen 6 family member s)
E: lymphocyte antigen 6 family member k (homo sapiens) (aka lymphocyte antigen 6 family member k)
F: None of the above. | F |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.', select the correct biomedical concept corresponding to 'cd59'. Answer using one of the provided options. | <Options>: A: cd59 (homo sapiens) (aka cd59 molecule (cd59 blood group))
B: cd51 (homo sapiens) (aka integrin subunit alpha v)
C: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
D: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
E: cd52 molecule (homo sapiens) (aka cd52 molecule)
F: None of the above. | A |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.', select the correct biomedical concept corresponding to 'membrane inhibitor of reactive lysis'. Answer using one of the provided options. | <Options>: A: cd5 (homo sapiens) (aka cd5 molecule)
B: migration and invasion inhibitory protein (bos taurus) (aka migration and invasion inhibitory protein)
C: intercellular adhesion molecule 1-like (bos taurus) (aka intercellular adhesion molecule 1-like)
D: ribonuclease/angiogenin inhibitor 1 (mus musculus) (aka ribonuclease/angiogenin inhibitor 1)
E: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
F: None of the above. | E |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.', select the correct biomedical concept corresponding to 'mirl'. Answer using one of the provided options. | <Options>: A: mire (homo sapiens) (aka sap30 divergent transcript)
B: mir (homo sapiens) (myosin regulatory light chain interacting protein (homo sapiens)) (aka myosin regulatory light chain interacting protein)
C: mirl (homo sapiens) (aka cd59 molecule (cd59 blood group))
D: mical-like (drosophila melanogaster) (aka mical-like)
E: mira (drosophila melanogaster) (aka miranda)
F: None of the above. | C |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.', select the correct biomedical concept corresponding to 'protectin'. Answer using one of the provided options. | <Options>: A: copper chaperone for superoxide dismutase (homo sapiens) (aka copper chaperone for superoxide dismutase)
B: serpinh2 (homo sapiens) (aka serpin family h member 1)
C: serp1 (homo sapiens) (aka stress associated endoplasmic reticulum protein 1)
D: placentin (homo sapiens) (aka insulin like 4)
E: pleiotrophin promoter (homo sapiens) (aka pleiotrophin promoter)
F: None of the above. | F |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.', select the correct biomedical concept corresponding to 'protectin'. Answer using one of the provided options. | <Options>: A: copper chaperone for superoxide dismutase (homo sapiens) (aka copper chaperone for superoxide dismutase)
B: serp1 (homo sapiens) (aka stress associated endoplasmic reticulum protein 1)
C: fallotein (homo sapiens) (aka platelet derived growth factor c)
D: serpinh1 (homo sapiens) (aka serpin family h member 1)
E: pleiotrophin promoter (homo sapiens) (aka pleiotrophin promoter)
F: None of the above. | F |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept corresponding to 'cd59'. Answer using one of the provided options. | <Options>: A: cd58 (homo sapiens) (aka cd58 molecule)
B: cd59 (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: cd5 (homo sapiens) (aka cd5 molecule)
D: cd52 (homo sapiens) (aka cd52 molecule)
E: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
F: None of the above. | B |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept corresponding to 'ly-6'. Answer using one of the provided options. | <Options>: A: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: slam family member 6 (homo sapiens) (aka slam family member 6)
C: lymphocyte antigen 6 family member s (homo sapiens) (aka lymphocyte antigen 6 family member s)
D: lir-6 (homo sapiens) (aka leukocyte immunoglobulin like receptor a1)
E: slam family member 7 (homo sapiens) (aka slam family member 7)
F: None of the above. | F |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept corresponding to 'cd59'. Answer using one of the provided options. | <Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cd5 (homo sapiens) (aka cd5 molecule)
C: cd58 (homo sapiens) (aka cd58 molecule)
D: cd59 (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: cd51 (homo sapiens) (aka integrin subunit alpha v)
F: None of the above. | D |
<Instruct>: Given the context 'The striking similarity in gene structure is further evidence that the two proteins belong to a superfamily of proteins that may also include the urokinase plasminogen-activator receptor and a squid glycoprotein of unknown function.', select the correct biomedical concept corresponding to 'urokinase plasminogen-activator receptor'. Answer using one of the provided options. | <Options>: A: plasminogen activator, urokinase (homo sapiens) (aka plasminogen activator, urokinase)
B: plasminogen activator, urokinase receptor (sus scrofa) (aka plasminogen activator, urokinase receptor)
C: plasminogen activator, urokinase receptor (mus musculus) (aka plasminogen activator, urokinase receptor)
D: urkr (homo sapiens) (aka plasminogen activator, urokinase receptor)
E: plasminogen activator, urokinase receptor (xenopus tropicalis) (aka plasminogen activator, urokinase receptor)
F: None of the above. | D |
<Instruct>: Given the context 'Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.
', select the correct biomedical concept corresponding to 'interleukin-1 receptor antagonist'. Answer using one of the provided options. | <Options>: A: interleukin 36 receptor antagonist (homo sapiens) (aka interleukin 36 receptor antagonist)
B: il1rp1 (homo sapiens) (aka interleukin 37)
C: interleukin 1 receptor antagonist (homo sapiens) (aka interleukin 1 receptor antagonist)
D: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
E: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
F: None of the above. | C |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical concept corresponding to 'interleukin-1 receptor antagonist'. Answer using one of the provided options. | <Options>: A: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
B: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
C: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
D: il1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
E: interleukin 36 receptor antagonist (homo sapiens) (aka interleukin 36 receptor antagonist)
F: None of the above. | D |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: il-1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
D: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
E: il-1racp (homo sapiens) (aka interleukin 1 receptor accessory protein)
F: None of the above. | C |
<Instruct>: Given the context 'The gene contains four exons which code for the secreted form of the IL-1ra, however, our clone does not contain the alternative first exon used to generate an intracellular form of the protein as the protein as found in epithelial cells.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: il1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
B: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
C: il-1racp (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
E: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the above. | A |
<Instruct>: Given the context 'By in-situ fluorescence hybridization we have shown that the IL-1ra gene is found on the long arm of chromosome 2 and maps to 2q13-14.1.', select the correct biomedical concept corresponding to 'il-1ra'. Answer using one of the provided options. | <Options>: A: interleukin 1 receptor antagonist (homo sapiens) (aka interleukin 1 receptor antagonist)
B: il1rap (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
D: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
E: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the above. | A |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 alpha'. Answer using one of the provided options. | <Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: il-1 (homo sapiens) (aka interleukin 1 beta)
C: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
D: il1-alpha (homo sapiens) (aka interleukin 1 alpha)
E: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
F: None of the above. | D |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 alpha'. Answer using one of the provided options. | <Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: il-1 (homo sapiens) (aka interleukin 1 beta)
C: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
D: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
E: None of the above. | E |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept corresponding to 'il-1 beta'. Answer using one of the provided options. | <Options>: A: il1beta (homo sapiens) (aka interleukin 1 beta)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: ifnb1 (homo sapiens) (aka interferon beta 1)
D: None of the above. | A |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin (sus scrofa) (aka aprataxin)
B: aprataxin (homo sapiens) (aka aprataxin)
C: aprataxin-like protein (arabidopsis thaliana) (aka aprataxin-like protein)
D: aprataxin (drosophila melanogaster) (aka aprataxin)
E: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
B: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
C: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
D: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
E: eaoh (homo sapiens) (aka aprataxin)
F: None of the above. | E |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'early-onset ataxia with ocular motor apraxia and hypoalbuminemia'. Answer using one of the provided options. | <Options>: A: cogan-type congential oculomotor apraxia (homo sapiens) (aka cogan-type congential oculomotor apraxia)
B: etaa16 (homo sapiens) (aka etaa1 activator of atr kinase)
C: epilepsy, occipitotemporal lobe, and migraine with aura (homo sapiens) (aka epilepsy, occipitotemporal lobe, and migraine with aura)
D: eaoh (homo sapiens) (aka aprataxin)
E: episodic ataxia, type 3 (homo sapiens) (aka episodic ataxia, type 3)
F: None of the above. | D |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apraxia, and hypoalbuminemia.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
B: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
C: eaoh (homo sapiens) (aka aprataxin)
D: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
E: etaa1 activator of atr kinase (homo sapiens) (aka etaa1 activator of atr kinase)
F: None of the above. | C |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept corresponding to 'eaoh'. Answer using one of the provided options. | <Options>: A: eoaha (homo sapiens) (aka aprataxin)
B: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
C: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
D: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
E: etaa1 (homo sapiens) (aka etaa1 activator of atr kinase)
F: None of the above. | A |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptx (xenopus tropicalis) (aka aprataxin)
B: aptx (homo sapiens) (aka aprataxin)
C: aptx (xenopus laevis) (aka aprataxin l homeolog)
D: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
E: aptx (drosophila melanogaster) (aka aprataxin)
F: None of the above. | B |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptx (xenopus tropicalis) (aka aprataxin)
B: aptx (mus musculus) (aka aprataxin)
C: aptx (drosophila melanogaster) (aka aprataxin)
D: aptx (homo sapiens) (aka aprataxin)
E: aptx (arabidopsis thaliana) (aka aprataxin-like protein)
F: None of the above. | D |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept corresponding to 'aptx'. Answer using one of the provided options. | <Options>: A: aptx (mus musculus) (aka aprataxin)
B: aptx (homo sapiens) (aka aprataxin)
C: aptx (arabidopsis thaliana) (aka aprataxin-like protein)
D: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
E: aptx (xenopus laevis) (aka aprataxin l homeolog)
F: None of the above. | B |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept corresponding to 'aprataxin'. Answer using one of the provided options. | <Options>: A: aprataxin-like (xenopus laevis) (aka aprataxin-like)
B: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
C: aprataxin (drosophila melanogaster) (aka aprataxin)
D: aprataxin (homo sapiens) (aka aprataxin)
E: aprataxin (mus musculus) (aka aprataxin)
F: None of the above. | D |
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