instruction stringlengths 225 2.35k | input stringlengths 89 1.5k | response stringclasses 698 values |
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<Instruct>: Given the context 'This method specifically amplifies sequences between Alu repeats from human DNA in somatic cell hybrids and yeast artificial chromosomes (YACs, 4).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human; yeast]
<Options>: A: saccharomyces hansenii (aka debaryomyces hansenii)
B: cellular organisms (biota) (aka cellular organisms)
C: saccharomyces cerevisiae x saccharomyces mikatae
D: true yeasts (aka saccharomycotina)
E: mycoderma cerevisiae (aka saccharomyces cerevisiae)
F: probles
G: primate (aka primates)
H: candida/saccharomycetales (aka candida/saccharomycales clade)
I: genus
J: homo sapiens (human) (aka homo sapiens)
K: None of the above. | [J; E] |
<Instruct>: Given the context 'This method specifically amplifies sequences between Alu repeats from human DNA in somatic cell hybrids and yeast artificial chromosomes (YACs, 4).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human; yeast]
<Options>: A: candida/saccharomycetales (aka candida/saccharomycales clade)
B: saccharomyces cerevisiae x saccharomyces mikatae
C: homo sapiens (human) (aka homo sapiens)
D: eutherian mammals (aka eutheria)
E: cellular organisms (biota) (aka cellular organisms)
F: saccharomyces hansenii (aka debaryomyces hansenii)
G: mycoderma cerevisiae (aka saccharomyces cerevisiae)
H: genus
I: saccharomycetes (hemiascomycetes) (aka saccharomycetes)
J: suborder
K: None of the above. | [C; G] |
<Instruct>: Given the context 'Two new human specific Alu primers were used to generate DNA probes from a series of irradiation-reduced hybrids containing multiple human X chromosome fragments of 1-2000 kb on a hamster chromosome background (5; P.N.G., unpublished).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: mammals (aka mammalia)
B: probles
C: primate (aka primates)
D: homo sapiens (human) (aka homo sapiens)
E: species
F: None of the above. | [D] |
<Instruct>: Given the context 'The Alu-PCR products were hybridized as a pool of probes to X-specific cosmid and YAC libraries, after
competitive reassociation with an excess of human DNA to both the library filters and radioactively labelled Alu-PCR products.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: humans (aka homo)
B: species
C: homo sapiens (human) (aka homo sapiens)
D: avian (aka aves)
E: probles
F: None of the above. | [C] |
<Instruct>: Given the context 'METHODS
Two human Alu sequence primers were generated which were shown to be human specific; 3144 from the 3' end of Alu: 5'-GAGCGAGACTCCGTCTCAAA-3' and 2729 from the 5' end of Alu: 5'-GTGGATCACCTGAGGTCAGGAGTTC-3'.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: human (aka homo sapiens)
B: mammals (aka mammalia)
C: genus
D: eutherian mammals (aka eutheria)
E: primate (aka primates)
F: None of the above. | [A] |
<Instruct>: Given the context 'Chinese hamster DNA and no DNA PCR reactions were done to control for non-human products (data not shown).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [chinese hamster; human]
<Options>: A: grey hamster (aka nothocricetulus migratorius)
B: animals (aka metazoa)
C: homo sapiens (human) (aka homo sapiens)
D: homo (humans) (aka homo)
E: cellular organisms (biota) (aka cellular organisms)
F: ciscaucasian hamster (aka mesocricetus raddei)
G: primate (aka primates)
H: syrian hamsters (aka mesocricetus auratus)
I: gansu hamster (aka cansumys canus)
J: chinese hamster (aka cricetulus griseus)
K: None of the above. | [J; C] |
<Instruct>: Given the context 'Chinese hamster DNA and no DNA PCR reactions were done to control for non-human products (data not shown).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [chinese hamster; human]
<Options>: A: chinese hamster (aka cricetulus griseus)
B: hamsters (aka cricetinae)
C: gansu hamster (aka cansumys canus)
D: birds (aka aves)
E: common hamster (aka cricetus cricetus)
F: human (aka homo sapiens)
G: kingdom
H: syrian hamster (aka mesocricetus auratus)
I: genus
J: suborder
K: None of the above. | [A; F] |
<Instruct>: Given the context 'The radioactively labelled pool of fragments was prehybridized with 37.5 ,^g of total human DNA and 12.5 tsg of hamster DNA immobilized on a cellulose support matrix, prepared as previously described (7).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: primate (aka primates)
B: human (aka homo sapiens)
C: homo (humans) (aka homo)
D: animals (aka metazoa)
E: species
F: None of the above. | [B] |
<Instruct>: Given the context 'I I
Figur 2a and 2b: Hybridization of Alu-PCR products generated with Alu primer 3144 from irradiation hybrid 48 to duplicate copies of 22 x22cm filters containing 9216 human X chromosome cosmids (8).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: homo sapiens (human) (aka homo sapiens)
B: mammals (aka mammalia)
C: probles
D: animals (aka metazoa)
E: species
F: None of the above. | [A] |
<Instruct>: Given the context 'Figure 1: A schematic diagram of the human X chromosome alongside the approximate cytogenetic location of fragments identified in nine irradiation hybrids (numbers across the top).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: kingdom
B: probles
C: species
D: human (aka homo sapiens)
E: animals (aka metazoa)
F: None of the above. | [D] |
<Instruct>: Given the context 'The human X fragments were identified by hybridization of 27 known DNA markers (indicated by a black line; P.N.G, unpublished) or by cosmids in common with unique X chromosome probes in the reference library database (open boxes and Table 1).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: cellular organisms (biota) (aka cellular organisms)
B: suborder
C: species
D: homo sapiens (human) (aka homo sapiens)
E: primate (aka primates)
F: None of the above. | [D] |
<Instruct>: Given the context 'denatured and sheared total human DNA in 50% formamide, 4XSSC, 0.05 M sodium phosphate pH 7.2, 0.001 M EDTA, 10% dextran sulphate, 1.0% SDS, 50 isg/ml denatured salmon sperm DNA and OxDenhardt's solution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: kingdom
B: human (aka homo sapiens)
C: species
D: mammals (aka mammalia)
E: homo (humans) (aka homo)
F: None of the above. | [B] |
<Instruct>: Given the context 'The radioactively labelled Alu-PCR products were denatured and added to fresh
hybridization solution without human DNA competitor at 1 x 106
cpm/ml and hybridized at 42?C for 16 hours.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: primate (aka primates)
B: human (aka homo sapiens)
C: probles
D: this
E: animals (aka metazoa)
F: None of the above. | [B] |
<Instruct>: Given the context 'For each hybridization, two sets of duplicate cosmid filters were used from the ICRF reference library system (8), each containing 9216 flow-sorted human X chromosome cosmid clones or approximately 2 chromosome equivalents on a 22 x 22 cm filter (9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: cellular organisms (biota) (aka cellular organisms)
B: humans (aka homo)
C: primate (aka primates)
D: homo sapiens (human) (aka homo sapiens)
E: animals (aka metazoa)
F: None of the above. | [D] |
<Instruct>: Given the context 'For each hybridization, two sets of duplicate cosmid filters were used from the ICRF reference library system (8), each containing 9216 flow-sorted human X chromosome cosmid clones or approximately 2 chromosome equivalents on a 22 x 22 cm filter (9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: primate (aka primates)
B: animals (aka metazoa)
C: cellular organisms (biota) (aka cellular organisms)
D: humans (aka homo)
E: None of the above. | [E] |
<Instruct>: Given the context 'RESULTS
A panel of 195 X chromosome irradiation hybrids was constructed (50,000 rads) and characterized by DNA hybridization using 27 X chromosome markers and flourescence in situ hybridization using total human DNA as probe (Benham et al., 1989; P.N.G., unpublished).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: human (aka homo sapiens)
B: macrobiotus sapiens
C: suborder
D: kingdom
E: primate (aka primates)
F: None of the above. | [A] |
<Instruct>: Given the context 'All nine hybrids were used in PCR reactions with 3'-Alu primer 3144 and two were used with 5'-Alu
Figure 3: Hybridization of Alu-PCR products generated with Alu primer 3144 from irradiation hybrid 54 to a filter containing 420 YAC clones from the human X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: birds (aka aves)
B: kingdom
C: mammals (aka mammalia)
D: macrobiotus sapiens
E: homo sapiens (human) (aka homo sapiens)
F: None of the above. | [E] |
<Instruct>: Given the context 'Example hybridizations to a human X chromosome cosmid filter in Fig 2 shows the intensity and reliability of positive clones identified on duplicate filters with Alu-PCR products from the same irradiation hybrid (48) and the independence of clones identified with Alu-PCR products from a different hybrid (54).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: human (aka homo sapiens)
B: mammals (aka mammalia)
C: kingdom
D: macrobiotus sapiens
E: birds (aka aves)
F: None of the above. | [A] |
<Instruct>: Given the context 'Fig 3 shows a single positive YAC clone after hybridization of Alu-PCR products from irradiation hybrid 54 to a filter containing about 420 YAC clones specific for the human X chromosome.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: animals (aka metazoa)
B: birds (aka aves)
C: primate (aka primates)
D: homo sapiens (human) (aka homo sapiens)
E: kingdom
F: None of the above. | [D] |
<Instruct>: Given the context 'Since only 27 probes from the X chromosome were used to initially characterize the hybrids and the length of individual human fragments in the irradiation hybrids is about 1000-5000 kb, many regions could have been undetected in the original analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: species
B: avian (aka aves)
C: animals (aka metazoa)
D: eutherian mammals (aka eutheria)
E: homo sapiens (human) (aka homo sapiens)
F: None of the above. | [E] |
<Instruct>: Given the context 'However, since the exact length of the human DNA fragments for each hybrid and the spacing of Alu-PCR products along the chromosome is not known, it is difficult to directly correlate the number of target cosmids to the DNA content of the hybrids.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human]
<Options>: A: genus
B: biota (aka cellular organisms)
C: homo sapiens (human) (aka homo sapiens)
D: species
E: primate (aka primates)
F: None of the above. | [C] |
<Instruct>: Given the context 'The dissection of a total genomic YAC library by this method may be more efficient than generating chromosome specific YAC libraries from somatic cell hybrids (usually a haploid human chromosome on a diploid or greater rodent background) or flow-sorted chromosomes, because of the low transformation efficiency of yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human; yeast]
<Options>: A: saccharomyces lactis (aka kluyveromyces lactis)
B: brewer's yeast (aka saccharomyces cerevisiae)
C: homo (humans) (aka homo)
D: probles
E: mammals (aka mammalia)
F: saccharomyces cf. cerevisiae
G: candida/saccharomycetales (aka candida/saccharomycales clade)
H: saccharomyces cerevisiae x saccharomyces mikatae
I: placental mammals (aka eutheria)
J: human (aka homo sapiens)
K: None of the above. | [J; B] |
<Instruct>: Given the context 'The dissection of a total genomic YAC library by this method may be more efficient than generating chromosome specific YAC libraries from somatic cell hybrids (usually a haploid human chromosome on a diploid or greater rodent background) or flow-sorted chromosomes, because of the low transformation efficiency of yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human; yeast]
<Options>: A: cellular organisms (biota) (aka cellular organisms)
B: saccharomyces lactis (aka kluyveromyces lactis)
C: mammals (aka mammalia)
D: humans (aka homo)
E: saccharomyceta
F: baker's yeast (aka saccharomyces cerevisiae)
G: saccharomyces hansenii (aka debaryomyces hansenii)
H: saccharomyces cerevisiae or paradoxus (aka saccharomyces cf. cerevisiae/paradoxus)
I: species
J: human (aka homo sapiens)
K: None of the above. | [J; F] |
<Instruct>: Given the context 'The dissection of a total genomic YAC library by this method may be more efficient than generating chromosome specific YAC libraries from somatic cell hybrids (usually a haploid human chromosome on a diploid or greater rodent background) or flow-sorted chromosomes, because of the low transformation efficiency of yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [human; yeast]
<Options>: A: saccharomyces hansenii (aka debaryomyces hansenii)
B: saccharomyceta
C: cellular organisms (biota) (aka cellular organisms)
D: humans (aka homo)
E: saccharomyces cerevisiae or paradoxus (aka saccharomyces cf. cerevisiae/paradoxus)
F: species
G: mammals (aka mammalia)
H: human (aka homo sapiens)
I: saccharomyces lactis (aka kluyveromyces lactis)
J: None of the above. | [H; J] |
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