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<Instruct>: Given the context 'Two independent experiments resulted in similar findings of 40% survival for HK-vaccinated mice with a mean survival time (MST) of 8 days versus 4 days in naïve mice (Fig. 1).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mice (aka mus <genus>) (aka mus <genus>) B: house mouse (aka mus musculus) C: western european house mouse (aka mus musculus domesticus) D: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) E: peromyscus F: None of the above.
[B]
<Instruct>: Given the context 'The administration of vaccines for B. mallei during an outbreak would mandate relatively rapid onset of protection for human or veterinary use.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; human] <Options>: A: avian (aka aves) B: mallomonas peronoides (aka mallomonas peroneides) C: burkholderia mallei (actinobacillus mallei) (aka burkholderia mallei) D: probles E: mucilaginibacter mallensis F: human (aka homo sapiens) G: inocybe subg. mallocybe (aka mallocybe) H: modicella malleola (endogone malleola) (aka modicella malleola) I: kingdom J: animals (aka metazoa) K: None of the above.
[C; F]
<Instruct>: Given the context 'The administration of vaccines for B. mallei during an outbreak would mandate relatively rapid onset of protection for human or veterinary use.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; human] <Options>: A: kingdom B: birds (aka aves) C: mucilaginibacter mallensis D: species E: homo sapiens (human) (aka homo sapiens) F: 'bartonella melophagi' (aka bartonella melophagi) G: mallocybe (inocybe subg. mallocybe) (aka mallocybe) H: malleco I: suborder J: bacillus mallei (aka burkholderia mallei) K: None of the above.
[J; E]
<Instruct>: Given the context 'Our results indicate that HK vaccination can afford partial protection to an otherwise lethal challenge of B. mallei by the i.p. route. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mucilaginibacter mallensis B: erysiphe malloti C: pseudomonas mallei (aka burkholderia mallei) D: mallocybe (inocybe subg. mallocybe) (aka mallocybe) E: malleco F: None of the above.
[C]
<Instruct>: Given the context 'Effects of cell depletion on HK-vaccinated survival To dissect the cellular basis for protection mediated by HK vaccination, 13 days after immunization with HK bacteria (day -1), and at day of challenge, mice were dosed with antibodies to deplete CD4+, CD8+ or B220+ cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: house mouse (aka mus musculus) B: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) C: peromyscus D: mus castaneus (aka mus musculus castaneus) E: mus sp. (mice (aka mus sp.)) F: None of the above.
[A]
<Instruct>: Given the context 'Antibody depletion of CD4+, CD8+, or B220+ cells in these mice was confirmed by flow cytometric analysis with depletion efficiencies for CD4, CD8, and B220 populations at 99.7%, 96%, and 95%, respectively, relative to mice treated with isotype control monoclonal antibodies (data not shown).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) B: mus musculoides (mus musculoides enclavae) (aka mus musculoides) C: house mouse (aka mus musculus) D: mus sp. (mice (aka mus sp.)) E: mus (aka mus <subgenus>) (aka mus <subgenus>) F: None of the above.
[C]
<Instruct>: Given the context 'Our results demonstrated decreased survival rates in B220 (p = 0.3418), CD4+ (p = 0.5417) and CD8+ (p = 0.4684) antibody depleted mice, compared to isotype control antibody, a finding that indicated a possible role for vaccine induced antibody production.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus musculus (house mouse) (aka mus musculus) B: mus musculoides (mus musculoides enclavae) (aka mus musculoides) C: mus (aka mus <subgenus>) (aka mus <subgenus>) D: mus cricetus (aka cricetus cricetus) E: mus castaneus (aka mus musculus castaneus) F: None of the above.
[A]
<Instruct>: Given the context 'When challenged with 2 × 107 CFU/mouse by the i.p. route, loss of T cells resulted in reduced survival (50%) relative to the non-specific isotype control (Fig. 2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: peromyscus B: mus cricetus (aka cricetus cricetus) C: mus musculus (house mouse) (aka mus musculus) D: mus sp. (mice (aka mus sp.)) E: eastern european house mouse (aka mus musculus musculus) F: None of the above.
[C]
<Instruct>: Given the context 'When challenged with 2 × 107 CFU/mouse by the i.p. route, loss of T cells resulted in reduced survival (50%) relative to the non-specific isotype control (Fig. 2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mus sp. (mice (aka mus sp.)) B: eastern european house mouse (aka mus musculus musculus) C: peromyscus D: mus cricetus (aka cricetus cricetus) E: None of the above.
[E]
<Instruct>: Given the context 'To further evaluate the necessity of these effector cells in providing protection following HK vaccination, relatively resistant C57BL/6 mice, deficient in mature B-cells (μMT), CD4 T-cells (CD4-/-) or CD8 T-cells (CD8-/-) were subjected to an identical HK vaccination and challenge regimen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus <genus> (mice (aka mus <genus>)) B: mus sp. (mice (aka mus sp.)) C: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) D: mouse (aka mus musculus) E: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) F: None of the above.
[D]
<Instruct>: Given the context 'Mature, B-cell-deficient mice demonstrated a 50% decreased survival (p = 0.0888) compared to the wild-type mice with an MST of 35.5 days (Fig. 3).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: western european house mouse (aka mus musculus domesticus) B: mus (aka mus <subgenus>) (aka mus <subgenus>) C: peromyscus D: house mouse (aka mus musculus) E: mus cricetus (aka cricetus cricetus) F: None of the above.
[D]
<Instruct>: Given the context 'CD4-/- and CD8-/- mice exhibited a 60% (p = 0.1343) and 0% reduced survival, respectively (Fig. 3). ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: house mouse (aka mus musculus) B: mice (aka mus <genus>) (aka mus <genus>) C: peromyscus D: mus castaneus (aka mus musculus castaneus) E: mus cricetus (aka cricetus cricetus) F: None of the above.
[A]
<Instruct>: Given the context 'Effects of cytokine depletion on HK vaccination Similar studies were performed to determine the role of IFN-γ or TNF-α in acute infection in BALB/c mice immunized with HK bacteria.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: peromyscus B: mus cricetus (aka cricetus cricetus) C: house mouse (aka mus musculus) D: mus (aka mus <genus>) (aka mus <genus>) E: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) F: None of the above.
[C]
<Instruct>: Given the context 'Six hours before challenge, mice were dosed with antibodies that neutralize IFN-γ or TNF-α.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mouse (aka mus musculus) B: mus (aka mus <subgenus>) (aka mus <subgenus>) C: eastern european house mouse (aka mus musculus musculus) D: peromyscus E: mus musculoides (mus musculoides enclavae) (aka mus musculoides) F: None of the above.
[A]
<Instruct>: Given the context 'Individual depletion of either TNF-α (p = 0.0145) or IFN-γ (p = 0.0446) resulted in 100% mortality with an MST of 3 and 2 days, respectively, compared to the HK-vaccinated isotype control mice (Fig. 4).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: eastern european house mouse (aka mus musculus musculus) B: peromyscus C: mice (aka mus sp.) (aka mus sp.) D: mouse (aka mus musculus) E: mus cricetus (aka cricetus cricetus) F: None of the above.
[D]
<Instruct>: Given the context 'In contrast, 40% of HK-vaccinated, isotype control mice survived to at least 12 days post-challenge (Fig 4).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus <subgenus> (mus (aka mus <subgenus>)) B: mice (aka mus sp.) (aka mus sp.) C: mus musculus (house mouse) (aka mus musculus) D: mouse (aka mus <genus>) E: mus domesticus (aka mus musculus domesticus) F: None of the above.
[C]
<Instruct>: Given the context 'To further evaluate the host TNF-α response during an established B. mallei chronic infection, we infected 12 BALB/c mice by the i.p. route with 1 × 106 CFU B. mallei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; mice] <Options>: A: malleomyces pseudomallei (aka burkholderia pseudomallei) B: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) C: mouse (aka mus musculus) D: inocybe subg. mallocybe (aka mallocybe) E: eastern european house mouse (aka mus musculus musculus) F: loefferella mallei (aka burkholderia mallei) G: mallomonas papillosa H: mus (aka mus <genus>) (aka mus <genus>) I: modicella malleola (endogone malleola) (aka modicella malleola) J: mus sp. (mice (aka mus sp.)) K: None of the above.
[F; C]
<Instruct>: Given the context 'To further evaluate the host TNF-α response during an established B. mallei chronic infection, we infected 12 BALB/c mice by the i.p. route with 1 × 106 CFU B. mallei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; mice] <Options>: A: malleco B: inocybe subg. mallocybe (aka mallocybe) C: mallomonas papillosa D: peromyscus E: bacillus mallei (aka burkholderia mallei) F: mus musculus (house mouse) (aka mus musculus) G: mus cricetus (aka cricetus cricetus) H: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) I: mus musculoides (mus musculoides enclavae) (aka mus musculoides) J: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) K: None of the above.
[E; F]
<Instruct>: Given the context 'On day 42 post-infection, the remaining 11 mice were dosed with either anti-TNF-α (n = 6), or control mAb (AFRC Mac 49) (n = 5).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus sp. (mice (aka mus sp.)) B: eastern european house mouse (aka mus musculus musculus) C: mus <subgenus> (mus (aka mus <subgenus>)) D: house mouse (aka mus musculus) E: peromyscus F: None of the above.
[D]
<Instruct>: Given the context 'No further deaths were observed in the control mAb-treated mice.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: peromyscus B: mus cricetus (aka cricetus cricetus) C: mus musculoides (mus musculoides enclavae) (aka mus musculoides) D: mus castaneus (aka mus musculus castaneus) E: mus musculus (house mouse) (aka mus musculus) F: None of the above.
[E]
<Instruct>: Given the context 'Rapid mortality was observed in the anti-TNF-α-treated group, with all mice dying within 7 days of treatment (p = 0.0023) relative to the isotype-treated controls (Fig. 5). ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mouse (aka mus musculus) B: eastern european house mouse (aka mus musculus musculus) C: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) D: mus (aka mus <subgenus>) (aka mus <subgenus>) E: peromyscus F: None of the above.
[A]
<Instruct>: Given the context 'J774A.1 uptake of serum treated B. mallei Complement mediated uptake assays were performed to evaluate opsonization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallocybe (inocybe subg. mallocybe) (aka mallocybe) B: malleomyces pseudomallei (aka burkholderia pseudomallei) C: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) D: malleco E: actinobacillus mallei (aka burkholderia mallei) F: None of the above.
[E]
<Instruct>: Given the context 'Results indicated enhanced bacterial uptake in J774A.1 phagocytes inoculated with serum treated B. mallei (p = .0082), compared to B. mallei alone, while heat-inactivated serum produced uptake percentages similar to those prior to serum addition (Fig. 6).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: erysiphe malloti B: bacillus mallei (aka burkholderia mallei) C: malleomyces pseudomallei (aka burkholderia pseudomallei) D: mucilaginibacter mallensis E: 'bartonella melophagi' (aka bartonella melophagi) F: None of the above.
[B]
<Instruct>: Given the context 'Immunoglobulin production in HK vaccinated BALB/c mice We further characterized the ability of HK vaccination to induce a predominant IgG isotype by determining IgG2a/IgG1 ratios in i.p. and i.n. vaccinated BALB/c mice.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus cricetus (aka cricetus cricetus) B: mus castaneus (aka mus musculus castaneus) C: mouse (aka mus musculus) D: mus (aka mus <subgenus>) (aka mus <subgenus>) E: peromyscus F: None of the above.
[C]
<Instruct>: Given the context 'Discussion Recent studies have shown a key role in protection from lethal challenge for IFN-γ in non-vaccinated mice from either NK and/or NKT cells following experimental exposure to B. mallei and B. pseudomallei [7,8].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei; b. pseudomallei] <Options>: A: mouse (aka mus musculus) B: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) C: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) D: mus castaneus (aka mus musculus castaneus) E: burkholderia pseudomallei 5(1949) F: burkholderia pseudomallei bdu 2 G: modicella malleola (endogone malleola) (aka modicella malleola) H: mucilaginibacter mallensis I: pfeifferella mallei (aka burkholderia mallei) J: mallocybe (inocybe subg. mallocybe) (aka mallocybe) K: mus domesticus (aka mus musculus domesticus) L: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) M: mus <subgenus> (mus (aka mus <subgenus>)) N: bacterium whitmori (aka burkholderia pseudomallei) O: mus sp. (mice (aka mus sp.)) P: None of the above.
[A; I; N]
<Instruct>: Given the context 'Discussion Recent studies have shown a key role in protection from lethal challenge for IFN-γ in non-vaccinated mice from either NK and/or NKT cells following experimental exposure to B. mallei and B. pseudomallei [7,8].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei; b. pseudomallei] <Options>: A: mallocybe (inocybe subg. mallocybe) (aka mallocybe) B: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) C: burkholderia pseudomallei bdu 2 D: modicella malleola (endogone malleola) (aka modicella malleola) E: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) F: mucilaginibacter mallensis G: mouse (aka mus musculus) H: mus castaneus (aka mus musculus castaneus) I: burkholderia pseudomallei 5(1949) J: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) K: mus sp. (mice (aka mus sp.)) L: mus domesticus (aka mus musculus domesticus) M: mus <subgenus> (mus (aka mus <subgenus>)) N: pfeifferella mallei (aka burkholderia mallei) O: None of the above.
[G; N; O]
<Instruct>: Given the context 'Discussion Recent studies have shown a key role in protection from lethal challenge for IFN-γ in non-vaccinated mice from either NK and/or NKT cells following experimental exposure to B. mallei and B. pseudomallei [7,8].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei; b. pseudomallei] <Options>: A: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) B: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) C: burkholderia thailandensis (burkholderia pseudomallei-like species) (aka burkholderia thailandensis) D: mus cricetus (aka cricetus cricetus) E: inocybe subg. mallocybe (aka mallocybe) F: burkholderia pseudomallei bdu 2 G: modicella malleola (endogone malleola) (aka modicella malleola) H: mus castaneus (aka mus musculus castaneus) I: mouse (aka mus musculus) J: mallomonas papillosa K: malleomyces mallei (aka burkholderia mallei) L: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) M: mouse (aka mus <genus>) N: burkholderia pseudomallei the (burkholderia pseudomallei strain the) (aka burkholderia pseudomallei the) O: malleomyces pseudomallei (aka burkholderia pseudomallei) P: None of the above.
[I; K; O]
<Instruct>: Given the context 'Discussion Recent studies have shown a key role in protection from lethal challenge for IFN-γ in non-vaccinated mice from either NK and/or NKT cells following experimental exposure to B. mallei and B. pseudomallei [7,8].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei; b. pseudomallei] <Options>: A: pfeifferella mallei (aka burkholderia mallei) B: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) C: inocybe subg. mallocybe (aka mallocybe) D: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) E: burkholderia thailandensis (burkholderia pseudomallei-like species) (aka burkholderia thailandensis) F: mallomonas peronoides (aka mallomonas peroneides) G: loefflerella pseudomallei (aka burkholderia pseudomallei) H: mus musculus (house mouse) (aka mus musculus) I: mus castaneus (aka mus musculus castaneus) J: peromyscus K: mallomonas papillosa L: mus musculoides (mus musculoides enclavae) (aka mus musculoides) M: pseudomallei group N: mus <genus> (mice (aka mus <genus>)) O: burkholderia pseudomallei cb (burkholderia pseudomallei strain cb) (aka burkholderia pseudomallei cb) P: None of the above.
[H; A; G]
<Instruct>: Given the context 'A similar protective role in the innate response to infection has been demonstrated for TNF-α in B. pseudomallei infection [8].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: burkholderia pseudomallei cb (burkholderia pseudomallei strain cb) (aka burkholderia pseudomallei cb) B: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) C: burkholderia pseudomallei strain the (aka burkholderia pseudomallei the) D: burkholderia thailandensis (burkholderia pseudomallei-like species) (aka burkholderia thailandensis) E: bacillus pseudomallei (aka burkholderia pseudomallei) F: None of the above.
[E]
<Instruct>: Given the context 'The studies presented here are consistent with the essential role of these factors in the relative levels of protection conferred by vaccination with heat-killed B. pseudomallei and would appear to be viable early markers for protection from lethal acute infection [9].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: bacillus pseudomallei (aka burkholderia pseudomallei) B: burkholderia pseudomallei 6(1960) C: burkholderia pseudomallei strain os (aka burkholderia pseudomallei os) D: burkholderia pseudomallei strain the (aka burkholderia pseudomallei the) E: burkholderia pseudomallei 5(1949) F: None of the above.
[A]
<Instruct>: Given the context 'Currently, there are no fully protective vaccines against B. mallei or B. pseudomallei in a murine model, particularly for the sensitive BALB/c versus C57BL6 models.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; b. pseudomallei; murine] <Options>: A: western european house mouse (aka mus musculus domesticus) B: mallomonas peronoides (aka mallomonas peroneides) C: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) D: burkholderia pseudomallei 6(1960) E: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) F: acinetobacter mallei (aka burkholderia mallei) G: mus musculoides (mus musculoides enclavae) (aka mus musculoides) H: mallomonas papillosa I: burkholderia pseudomallei 5(1949) J: modicella malleola (endogone malleola) (aka modicella malleola) K: pseudomallei group L: burkholderia pseudomallei (loefflerella pseudomallei) (aka burkholderia pseudomallei) M: mouse (aka mus musculus) N: peromyscus O: mice (aka mus sp.) (aka mus sp.) P: None of the above.
[F; L; M]
<Instruct>: Given the context 'Currently, there are no fully protective vaccines against B. mallei or B. pseudomallei in a murine model, particularly for the sensitive BALB/c versus C57BL6 models.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; b. pseudomallei; murine] <Options>: A: mucilaginibacter mallensis B: inocybe subg. mallocybe (aka mallocybe) C: pseudomallei group D: mus cricetus (aka cricetus cricetus) E: burkholderia pseudomallei (loefflerella pseudomallei) (aka burkholderia pseudomallei) F: malleomyces pseudomallei (aka burkholderia pseudomallei) G: mus norvegicus (aka rattus norvegicus) H: mus musculoides (mus musculoides enclavae) (aka mus musculoides) I: mus <genus> (mice (aka mus <genus>)) J: malleco K: burkholderia pseudomallei bdu 2 L: burkholderia pseudomallei strain the (aka burkholderia pseudomallei the) M: pseudomonas mallei (aka burkholderia mallei) N: mouse (aka mus musculus) O: burkholderia pseudomallei 6(1960) P: None of the above.
[M; E; N]
<Instruct>: Given the context 'Currently, there are no fully protective vaccines against B. mallei or B. pseudomallei in a murine model, particularly for the sensitive BALB/c versus C57BL6 models.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei; b. pseudomallei; murine] <Options>: A: 'bartonella melophagi' (aka bartonella melophagi) B: mus <genus> (mice (aka mus <genus>)) C: mucilaginibacter mallensis D: burkholderia pseudomallei strain the (aka burkholderia pseudomallei the) E: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) F: malleomyces mallei (aka burkholderia mallei) G: mus musculoides (mus musculoides enclavae) (aka mus musculoides) H: malleomyces pseudomallei (aka burkholderia pseudomallei) I: mus musculus (house mouse) (aka mus musculus) J: burkholderia pseudomallei cms (burkholderia pseudomallei strain cms) (aka burkholderia pseudomallei cms) K: mus norvegicus (aka rattus norvegicus) L: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) M: peromyscus N: burkholderia thailandensis (burkholderia pseudomallei-like species) (aka burkholderia thailandensis) O: None of the above.
[F; H; I]
<Instruct>: Given the context 'Previous studies have also demonstrated that both the humoral and cell-mediated arms are essential for protection from B. pseudomallei infection [10].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: burkholderia pseudomallei os (burkholderia pseudomallei strain os) (aka burkholderia pseudomallei os) B: burkholderia pseudomallei 5(1949) C: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) D: pseudomallei group E: bacillus pseudomallei (aka burkholderia pseudomallei) F: None of the above.
[E]
<Instruct>: Given the context 'Thus, loss or reduction of TNF-α and IFN-γ levels result in significantly reduced survival rates, substantiating previous reports of the role of these factors in protection against B. mallei [7].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: bacillus mallei (aka burkholderia mallei) B: mallocybe (inocybe subg. mallocybe) (aka mallocybe) C: malleomyces pseudomallei (aka burkholderia pseudomallei) D: erysiphe malloti E: mucilaginibacter mallensis F: None of the above.
[A]
<Instruct>: Given the context 'Moreover, we demonstrate a role for sustained TNF-α production in the maintenance of host survival throughout the course of B. mallei infection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallocybe (inocybe subg. mallocybe) (aka mallocybe) B: malleomyces mallei (aka burkholderia mallei) C: malleco D: erysiphe malloti E: modicella malleola (endogone malleola) (aka modicella malleola) F: None of the above.
[B]
<Instruct>: Given the context 'Moreover, we demonstrate a role for sustained TNF-α production in the maintenance of host survival throughout the course of B. mallei infection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: erysiphe malloti B: malleco C: modicella malleola (endogone malleola) (aka modicella malleola) D: mallocybe (inocybe subg. mallocybe) (aka mallocybe) E: None of the above.
[E]
<Instruct>: Given the context 'Mice with an established B. mallei chronic infection rapidly lost the ability to control the growth of the bacillus upon neutralization of TNF-α.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: mus musculus (house mouse) (aka mus musculus) B: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) C: mallocybe (inocybe subg. mallocybe) (aka mallocybe) D: mus <subgenus> (mus (aka mus <subgenus>)) E: peromyscus F: mallomonas papillosa G: mus cricetus (aka cricetus cricetus) H: mallomonas peronoides (aka mallomonas peroneides) I: mice (aka mus sp.) (aka mus sp.) J: bacillus mallei (aka burkholderia mallei) K: None of the above.
[A; J]
<Instruct>: Given the context 'Mice with an established B. mallei chronic infection rapidly lost the ability to control the growth of the bacillus upon neutralization of TNF-α.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: malleco B: mus castaneus (aka mus musculus castaneus) C: mus musculoides (mus musculoides enclavae) (aka mus musculoides) D: mallomonas peronoides (aka mallomonas peroneides) E: malleomyces pseudomallei (aka burkholderia pseudomallei) F: western european house mouse (aka mus musculus domesticus) G: mallomonas papillosa H: pfeifferella mallei (aka burkholderia mallei) I: eastern european house mouse (aka mus musculus musculus) J: mouse (aka mus musculus) K: None of the above.
[J; H]
<Instruct>: Given the context 'Additional studies are underway to determine more precisely the role of TNF-α in host protection to B. mallei. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallocybe (inocybe subg. mallocybe) (aka mallocybe) B: modicella malleola (endogone malleola) (aka modicella malleola) C: erysiphe malloti D: mucilaginibacter mallensis E: burkholderia mallei (actinobacillus mallei) (aka burkholderia mallei) F: None of the above.
[E]
<Instruct>: Given the context 'Multiple innate and adaptive cell types may contribute to the production of IFN-γ in response to infection with B. mallei following vaccination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: pfeifferella mallei (aka burkholderia mallei) B: modicella malleola (endogone malleola) (aka modicella malleola) C: malleco D: erysiphe malloti E: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) F: None of the above.
[A]
<Instruct>: Given the context 'The effector role for IFN-γ in mediating protection against B. mallei may include both immunoregulatory and non-regulatory functions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: malleco B: mallomonas papillosa C: mucilaginibacter mallensis D: 'bartonella melophagi' (aka bartonella melophagi) E: bacillus mallei (aka burkholderia mallei) F: None of the above.
[E]
<Instruct>: Given the context 'Regardless, the requirement of IFN-γ, as demonstrated by administration of neutralizing antibody prior to infection, indicates that stimulation of IFN-γ response is a desirable goal for a B. mallei vaccine. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: modicella malleola (endogone malleola) (aka modicella malleola) B: erysiphe malloti C: malleomyces mallei (aka burkholderia mallei) D: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) E: malleomyces pseudomallei (aka burkholderia pseudomallei) F: None of the above.
[C]
<Instruct>: Given the context 'Similarly, B220-positive cells appear to play a role in protection following vaccination with heat-killed B. mallei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: malleco B: acinetobacter mallei (aka burkholderia mallei) C: malleomyces pseudomallei (aka burkholderia pseudomallei) D: mallomonas peronoides (aka mallomonas peroneides) E: mallomonas papillosa F: None of the above.
[B]
<Instruct>: Given the context 'Protection against B. pseudomallei infection by anti-LPS, capsular polysaccharide and proteins has been short-lived, suggesting that antibody production offers limited protection in the initial stages of infection by an as-yet-undefined mechanism [12].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: pseudomallei group B: loefflerella pseudomallei (aka burkholderia pseudomallei) C: burkholderia pseudomallei os (burkholderia pseudomallei strain os) (aka burkholderia pseudomallei os) D: burkholderia pseudomallei 5(1949) E: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) F: None of the above.
[B]
<Instruct>: Given the context 'Protection against B. pseudomallei infection by anti-LPS, capsular polysaccharide and proteins has been short-lived, suggesting that antibody production offers limited protection in the initial stages of infection by an as-yet-undefined mechanism [12].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: burkholderia pseudomallei os (burkholderia pseudomallei strain os) (aka burkholderia pseudomallei os) B: burkholderia pseudomallei 5(1949) C: pseudomallei group D: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) E: None of the above.
[E]
<Instruct>: Given the context 'We have shown that following depletion of B220+ cells, survival rates decreased as much as 100% relative to non-depleted controls and individual CD4/CD8-depleted mice via the intraperitoneal route.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus sp. (mice (aka mus sp.)) B: mus cricetus (aka cricetus cricetus) C: mus (aka mus <genus>) (aka mus <genus>) D: mouse (aka mus musculus) E: mus <subgenus> (mus (aka mus <subgenus>)) F: None of the above.
[D]
<Instruct>: Given the context 'Results from C57BL/6 mice deficient in mature B-cells (μMT), CD4 T-cells (CD4-/-) or CD8 T-cells (CD8-/-) substantiate the requirement for B-cell involvement by evidence of μMT and CD4-/- decreased survival.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mouse (aka mus musculus) B: mus cricetus (aka cricetus cricetus) C: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) D: mus musculoides (mus musculoides enclavae) (aka mus musculoides) E: mus <subgenus> (mus (aka mus <subgenus>)) F: None of the above.
[A]
<Instruct>: Given the context 'In CD4-deficient mice, we have the additional potential variable that a CD4-dependent antibody response might also be inhibited during the vaccination phase relative to mice treated with antibody immediately prior to and during the early phases of infection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus sp. (mice (aka mus sp.)) B: mouse (aka mus musculus) C: mouse (aka mus <genus>) D: mus <subgenus> (mus (aka mus <subgenus>)) E: peromyscus F: None of the above.
[B]
<Instruct>: Given the context 'Although not statistically significant, we did observe a decrease in survival in μMT (mature B cell) deficient mice as early as day 9 post challenge, whereas CD4-deficient mice produced similar results at day 32 post challenge, indicating a role for B cells independent of CD4 T cell help, perhaps through a T-independent mechanism of antibody production.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mouse (aka mus musculus) B: mouse (aka mus <genus>) C: mice (aka mus sp.) (aka mus sp.) D: mus <subgenus> (mus (aka mus <subgenus>)) E: mus domesticus (aka mus musculus domesticus) F: None of the above.
[A]
<Instruct>: Given the context 'Although CD8-/- C57BL/6 demonstrated no decreased survival in our HK-vaccinated model, a lack of potential endogenous protein production by HK B. mallei may have contributed to limited MHC-I presentation. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: bacillus mallei (aka burkholderia mallei) B: mallocybe (inocybe subg. mallocybe) (aka mallocybe) C: mallomonas papillosa D: mucilaginibacter mallensis E: malleomyces pseudomallei (aka burkholderia pseudomallei) F: None of the above.
[A]
<Instruct>: Given the context 'Complement associated studies revealed increased J774A.1 uptake of serum-treated B. mallei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mucilaginibacter mallensis B: acinetobacter mallei (aka burkholderia mallei) C: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) D: erysiphe malloti E: mallocybe (inocybe subg. mallocybe) (aka mallocybe) F: None of the above.
[B]
<Instruct>: Given the context 'Complement-mediated uptake studies of B. pseudomallei by polymorphonuclear leukocytes (PMNs) suggest that capsule production contributes to resistance of phagocytosis by reducing C3b bacterial deposition', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. pseudomallei] <Options>: A: burkholderia pseudomallei strain the (aka burkholderia pseudomallei the) B: burkholderia pseudomallei 5(1949) C: pseudomonas pseudomallei (aka burkholderia pseudomallei) D: burkholderia pseudomallei cs (burkholderia pseudomallei strain cs) (aka burkholderia pseudomallei cs) E: burkholderia pseudomallei os (burkholderia pseudomallei strain os) (aka burkholderia pseudomallei os) F: None of the above.
[C]
<Instruct>: Given the context 'Previous studies have demonstrated that a polysaccharide capsule is present in B. mallei, [14,15] although in the present study enhanced uptake with serum-treated B. mallei was observed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) B: mallocybe (inocybe subg. mallocybe) (aka mallocybe) C: pseudomonas mallei (aka burkholderia mallei) D: erysiphe malloti E: mallomonas papillosa F: None of the above.
[C]
<Instruct>: Given the context 'Previous reports have demonstrated the ability of B. mallei to survive within macrophage without the aid of serum coating organisms [16].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: 'bartonella melophagi' (aka bartonella melophagi) B: mallomonas peronoides (aka mallomonas peroneides) C: modicella malleola (endogone malleola) (aka modicella malleola) D: mallomonas papillosa E: malleomyces mallei (aka burkholderia mallei) F: None of the above.
[E]
<Instruct>: Given the context 'The current results suggest that cobra venom factor treatment may affect the modulation of the immune response to B. mallei infection through B cell activation and/or memory B cell generation. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallomonas papillosa B: bacillus mallei (aka burkholderia mallei) C: mucilaginibacter mallensis D: mallocybe (inocybe subg. mallocybe) (aka mallocybe) E: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) F: None of the above.
[B]
<Instruct>: Given the context 'The current results suggest that cobra venom factor treatment may affect the modulation of the immune response to B. mallei infection through B cell activation and/or memory B cell generation. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallomonas papillosa B: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) C: mallocybe (inocybe subg. mallocybe) (aka mallocybe) D: mucilaginibacter mallensis E: None of the above.
[E]
<Instruct>: Given the context 'Conclusion In summary, our results provide a basis for future studies of protection via vaccination using either subunit or whole-organism vaccine preparations from lethal infection in the experimental BALB/c mouse model.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mouse (aka mus <genus>) B: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) C: mus sp. (mice (aka mus sp.)) D: mus molossinus (aka mus musculus molossinus) E: house mouse (aka mus musculus) F: None of the above.
[E]
<Instruct>: Given the context 'Understanding and defining the role of B cells in adaptive B. mallei immunity will likely be fundamental to the design of an efficacious vaccine and important goals of future research. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: loefferella mallei (aka burkholderia mallei) B: mucilaginibacter mallensis C: mallomonas papillosa D: 'bartonella melophagi' (aka bartonella melophagi) E: erysiphe malloti F: None of the above.
[A]
<Instruct>: Given the context 'Methods Bacterial strain and mice B. mallei strain ATCC 23344 (China 7) was cultured on Luria-Bertani agar supplemented with 4% glycerol (LB+4%G) agar plates for 48 h at 37°C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: erysiphe malloti B: mallomonas peronoides (aka mallomonas peroneides) C: house mouse (aka mus musculus) D: mus cricetus (aka cricetus cricetus) E: mus castaneus (aka mus musculus castaneus) F: mus sp. (mice (aka mus sp.)) G: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) H: mallomonas papillosa I: pfeifferella mallei (aka burkholderia mallei) J: malleomyces pseudomallei (aka burkholderia pseudomallei) K: None of the above.
[C; I]
<Instruct>: Given the context 'Methods Bacterial strain and mice B. mallei strain ATCC 23344 (China 7) was cultured on Luria-Bertani agar supplemented with 4% glycerol (LB+4%G) agar plates for 48 h at 37°C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: peromyscus B: burkholderia mallei (actinobacillus mallei) (aka burkholderia mallei) C: mouse (aka mus <genus>) D: mallomonas papillosa E: mouse (aka mus musculus) F: malleco G: mucilaginibacter mallensis H: mus musculoides (mus musculoides enclavae) (aka mus musculoides) I: erysiphe malloti J: mus cricetus (aka cricetus cricetus) K: None of the above.
[E; B]
<Instruct>: Given the context 'The absence of live B. mallei organisms in the HK preparations was confirmed after plating 10% of the total inoculums (v/v) and incubating these at 37°C for 48 h.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: malleco B: malleomyces pseudomallei (aka burkholderia pseudomallei) C: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) D: mallomonas papillosa E: actinobacillus mallei (aka burkholderia mallei) F: None of the above.
[E]
<Instruct>: Given the context 'Female, 6- to 8-week-old, BALB/c mice (n = 5–7) were obtained from Harlan Sprague Dawley, Inc. (Indianapolis, Indiana).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus (aka mus <subgenus>) (aka mus <subgenus>) B: mus musculoides (mus musculoides enclavae) (aka mus musculoides) C: mouse (aka mus musculus) D: mus domesticus (aka mus musculus domesticus) E: peromyscus F: None of the above.
[C]
<Instruct>: Given the context 'Female, 6- to 8-week-old, C57BL/6 mice deficient in mature B-cells (μMT), CD4 T-cells (CD4-/-) and CD8 T-cells (CD8-/-) and wild-type mice were obtained from The Jackson Laboratory (Bar Harbor, Maine). ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) B: mus castaneus (aka mus musculus castaneus) C: mus (aka mus <subgenus>) (aka mus <subgenus>) D: mouse (aka mus musculus) E: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) F: None of the above.
[D]
<Instruct>: Given the context 'Vaccination and challenge BALB/c and C57BL/6 mice were grouped and vaccinated with 0.5 μg of HK B. mallei (without adjuvant) by i.p. injection using a 25-gauge syringe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: pseudomonas mallei (aka burkholderia mallei) B: mus castaneus (aka mus musculus castaneus) C: mus sp. (mice (aka mus sp.)) D: modicella malleola (endogone malleola) (aka modicella malleola) E: mus musculoides (mus musculoides enclavae) (aka mus musculoides) F: malleco G: house mouse (aka mus musculus) H: western european house mouse (aka mus musculus domesticus) I: malleomyces pseudomallei (aka burkholderia pseudomallei) J: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) K: None of the above.
[G; A]
<Instruct>: Given the context 'Vaccination and challenge BALB/c and C57BL/6 mice were grouped and vaccinated with 0.5 μg of HK B. mallei (without adjuvant) by i.p. injection using a 25-gauge syringe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice; b. mallei] <Options>: A: mice (aka mus <genus>) (aka mus <genus>) B: actinobacillus mallei (aka burkholderia mallei) C: malleomyces pseudomallei (aka burkholderia pseudomallei) D: mus (aka mus <subgenus>) (aka mus <subgenus>) E: mouse (aka mus musculus) F: mallomonas peronoides (aka mallomonas peroneides) G: peromyscus H: mallocybe (inocybe subg. mallocybe) (aka mallocybe) I: mucilaginibacter mallensis J: mice (aka mus sp.) (aka mus sp.) K: None of the above.
[E; B]
<Instruct>: Given the context 'Two weeks post HK vaccination mice were injected i.p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus castaneus (aka mus musculus castaneus) B: mice (aka mus sp.) (aka mus sp.) C: western european house mouse (aka mus musculus domesticus) D: mus musculoides (mus musculoides enclavae) (aka mus musculoides) E: house mouse (aka mus musculus) F: None of the above.
[E]
<Instruct>: Given the context 'with 2 × 107 CFU/100 μl of live B. mallei (~20 LD50)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: pfeifferella mallei (aka burkholderia mallei) B: mucilaginibacter mallensis C: malleco D: modicella malleola (endogone malleola) (aka modicella malleola) E: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) F: None of the above.
[A]
<Instruct>: Given the context 'Cell and cytokine depletions Acute in vivo cell/cytokine depletion was performed with monoclonal rat anti-mouse CD4 (GK1.5), CD8α (53-6.7) or B220 (RA3-6B2) obtained from R&D Systems, Inc. (Minneapolis, MN) by methods similar to those we have previously described [19].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) B: mus sp. (mice (aka mus sp.)) C: mus musculoides (mus musculoides enclavae) (aka mus musculoides) D: black rat (aka rattus rattus) E: western european house mouse (aka mus musculus domesticus) F: rattus rattoides (aka rattus pyctoris) G: mus musculus (house mouse) (aka mus musculus) H: rattus norvegicus albus I: mus norvegicus (aka rattus norvegicus) J: rattus sp. (rats (aka rattus sp.)) K: None of the above.
[I; G]
<Instruct>: Given the context 'Cell and cytokine depletions Acute in vivo cell/cytokine depletion was performed with monoclonal rat anti-mouse CD4 (GK1.5), CD8α (53-6.7) or B220 (RA3-6B2) obtained from R&D Systems, Inc. (Minneapolis, MN) by methods similar to those we have previously described [19].', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: peromyscus B: mus musculus (house mouse) (aka mus musculus) C: mice (aka mus sp.) (aka mus sp.) D: rattus norvegicus albus E: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) F: black rat (aka rattus rattus) G: norway rat (aka rattus norvegicus) H: rats (aka rattus sp.) (aka rattus sp.) I: mus cricetus (aka cricetus cricetus) J: rattus pyctoris (rattus rattoides) (aka rattus pyctoris) K: None of the above.
[G; B]
<Instruct>: Given the context 'Functional grade purified rat anti-mouse interferon-gamma (IFN-γ, AN-18) was obtained from eBioscience (San Diego, CA) and purified anti-mouse tumor necrosis factor (TNF-α, MP6-XT3) from BD Pharmingen (San Diego, CA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: mus musculoides (mus musculoides enclavae) (aka mus musculoides) B: rats (aka rattus sp.) (aka rattus sp.) C: western european house mouse (aka mus musculus domesticus) D: rats (aka rattus) (aka rattus) E: peromyscus F: mus musculus (house mouse) (aka mus musculus) G: black rat (aka rattus rattus) H: rattus norvegicus albus I: mice (aka mus sp.) (aka mus sp.) J: brown rat (aka rattus norvegicus) K: None of the above.
[J; F]
<Instruct>: Given the context 'Functional grade purified rat anti-mouse interferon-gamma (IFN-γ, AN-18) was obtained from eBioscience (San Diego, CA) and purified anti-mouse tumor necrosis factor (TNF-α, MP6-XT3) from BD Pharmingen (San Diego, CA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: rattus pyctoris (rattus rattoides) (aka rattus pyctoris) B: eastern european house mouse (aka mus musculus musculus) C: mus <subgenus> (mus (aka mus <subgenus>)) D: mus musculus (house mouse) (aka mus musculus) E: roof rat (aka rattus rattus) F: rattus norvegicus albus G: peromyscus H: rattus (rats (aka rattus)) I: mus norvegicus (aka rattus norvegicus) J: mus musculoides (mus musculoides enclavae) (aka mus musculoides) K: None of the above.
[I; D]
<Instruct>: Given the context 'IFN-γ and TNF-α antibodies were injected i.p. 6 h prior to challenge, 200 μg per mouse in 200 μl PBS or at later time points as indicated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mus cricetus (aka cricetus cricetus) B: mus <genus> (mice (aka mus <genus>)) C: peromyscus D: mus musculus (house mouse) (aka mus musculus) E: mice (aka mus sp.) (aka mus sp.) F: None of the above.
[D]
<Instruct>: Given the context 'Rat IgG isotype control was obtained from Southern Biotech (Birmingham, AL) and administered i.p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat] <Options>: A: rattus norvegicus albus B: rattus pyctoris (rattus rattoides) (aka rattus pyctoris) C: rats (aka rattus norvegicus) (aka rattus norvegicus) D: rattus sp. (rats (aka rattus sp.)) E: rattus rattoides (aka rattus rattus) F: None of the above.
[C]
<Instruct>: Given the context 'on day of challenge, 200 μg/mouse.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mus sp. (mice (aka mus sp.)) B: mus musculus (house mouse) (aka mus musculus) C: mus molossinus (aka mus musculus molossinus) D: mus cricetus (aka cricetus cricetus) E: mus (aka mus <subgenus>) (aka mus <subgenus>) F: None of the above.
[B]
<Instruct>: Given the context 'Rat anti-mouse CD4, CD8α and B220 were injected i.p. twice, 1 day prior to challenge and on day of challenge, with an equivalent dosage sufficient to deplete T or B cells from 6 × 108 bone marrow cells per injection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: mice (aka mus sp.) (aka mus sp.) B: rattus norvegicus albus C: mus domesticus (aka mus musculus domesticus) D: brown rat (aka rattus norvegicus) E: rattus pyctoris (rattus rattoides) (aka rattus pyctoris) F: mus cricetus (aka cricetus cricetus) G: mus musculus (house mouse) (aka mus musculus) H: rattus sp. (rats (aka rattus sp.)) I: mus molossinus (aka mus musculus molossinus) J: rat (aka rattus) (aka rattus) K: None of the above.
[D; G]
<Instruct>: Given the context 'Rat anti-mouse CD4, CD8α and B220 were injected i.p. twice, 1 day prior to challenge and on day of challenge, with an equivalent dosage sufficient to deplete T or B cells from 6 × 108 bone marrow cells per injection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: peromyscus B: rats (aka rattus) (aka rattus) C: mus cricetus (aka cricetus cricetus) D: mus musculoides (mus musculoides enclavae) (aka mus musculoides) E: rattus sp. (rats (aka rattus sp.)) F: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) G: mus musculus (house mouse) (aka mus musculus) H: rattus rattoides (aka rattus pyctoris) I: rattus norvegicus albus J: brown rat (aka rattus norvegicus) K: None of the above.
[J; G]
<Instruct>: Given the context 'Rat anti-mouse CD4, CD8α and B220 were injected i.p. twice, 1 day prior to challenge and on day of challenge, with an equivalent dosage sufficient to deplete T or B cells from 6 × 108 bone marrow cells per injection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: rattus sp. (rats (aka rattus sp.)) B: brown rat (aka rattus norvegicus) C: peromyscus D: rattus rattoides (aka rattus pyctoris) E: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) F: mus musculoides (mus musculoides enclavae) (aka mus musculoides) G: rats (aka rattus) (aka rattus) H: rattus norvegicus albus I: mus cricetus (aka cricetus cricetus) J: None of the above.
[B; J]
<Instruct>: Given the context 'Complement depletion with cobra venom factor Mice, six to seven per group, were vaccinated i.p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus musculus musculus (eastern european house mouse) (aka mus musculus musculus) B: house mouse (aka mus musculus) C: mus cricetus (aka cricetus cricetus) D: peromyscus E: mouse (aka mus <genus>) F: None of the above.
[B]
<Instruct>: Given the context 'with 1 × 105 CFU of nonviable B. mallei cell preparation in a total volume of 0.1 ml.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallomonas peroneides (mallomonas peronoides) (aka mallomonas peroneides) B: bartonella melophagi (candidatus bartonella melophagi) (aka bartonella melophagi) C: malleomyces mallei (aka burkholderia mallei) D: erysiphe malloti E: inocybe subg. mallocybe (aka mallocybe) F: None of the above.
[C]
<Instruct>: Given the context 'Two weeks later, 24 h and 1 h before challenge, complement depleted mice were treated i.p. with 12.5 units total cobra venom factor (Quidel Corporation Speciality Products, San Diego, CA) in 0.1 ml of PBS.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus (aka mus <genus>) (aka mus <genus>) B: house mouse (aka mus musculus) C: mus musculus domesticus (western european house mouse) (aka mus musculus domesticus) D: eastern european house mouse (aka mus musculus musculus) E: mus <subgenus> (mus (aka mus <subgenus>)) F: None of the above.
[B]
<Instruct>: Given the context 'Complement depletion was confirmed prior to challenge by micro-titer hemolytic complement activity (CH50) assay as previously described [20]. B. mallei J774A.1 uptake assays J774A.1 cells were seeded (5 × 105) onto Corning costar 24 well plates (Corning, NY) with DMEM and incubated overnight at 37°C with 5% CO2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: 'bartonella melophagi' (aka bartonella melophagi) B: loefferella mallei (aka burkholderia mallei) C: mallocybe (inocybe subg. mallocybe) (aka mallocybe) D: malleco E: erysiphe malloti F: None of the above.
[B]
<Instruct>: Given the context 'Bacterial suspensions were incubated at 37°C for 45 minutes supplemented with 2% mouse serum from Sigma-Aldrich (St. Louis, MO.), heat inactivated mouse serum (56°C 30 minutes), or bacteria alone and then added at an MOI of 10:1 to J774A.1 cells in triplicate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: peromyscus B: house mouse (aka mus musculus) C: mus molossinus (aka mus musculus molossinus) D: mus musculoides (mus musculoides enclavae) (aka mus musculoides) E: mice (aka mus sp.) (aka mus sp.) F: None of the above.
[B]
<Instruct>: Given the context 'Antibodies used for analysis of surface markers included: FITC-conjugated rat anti-mouse CD45R/B220 (RA3-6B2, BD Pharmingen San Diego, CA) for B cells; FITC-conjugated rat anti-mouse CD8α (53-6.7) and CD4 (GK1.5, BD Pharmingen, San Diego, CA) for CD8+ or CD4+ cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: rat (aka rattus norvegicus) (aka rattus norvegicus) B: rattus rattoides (aka rattus pyctoris) C: western european house mouse (aka mus musculus domesticus) D: mus (aka mus <subgenus>) (aka mus <subgenus>) E: rattus norvegicus albus F: mus musculoides (mus musculoides enclavae) (aka mus musculoides) G: rattus (rats (aka rattus)) H: rattus rattus (rattus wroughtoni) (aka rattus rattus) I: house mouse (aka mus musculus) J: mice (aka mus <genus>) (aka mus <genus>) K: None of the above.
[A; I]
<Instruct>: Given the context 'Antibodies used for analysis of surface markers included: FITC-conjugated rat anti-mouse CD45R/B220 (RA3-6B2, BD Pharmingen San Diego, CA) for B cells; FITC-conjugated rat anti-mouse CD8α (53-6.7) and CD4 (GK1.5, BD Pharmingen, San Diego, CA) for CD8+ or CD4+ cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [rat; mouse] <Options>: A: rattus rattus (rattus wroughtoni) (aka rattus rattus) B: mus sp. (mice (aka mus sp.)) C: western european house mouse (aka mus musculus domesticus) D: eastern european house mouse (aka mus musculus musculus) E: rattus norvegicus (rats (aka rattus norvegicus)) F: mouse (aka mus musculus) G: rats (aka rattus sp.) (aka rattus sp.) H: rattus rattoides (aka rattus pyctoris) I: rattus norvegicus albus J: mus musculoides (mus musculoides enclavae) (aka mus musculoides) K: None of the above.
[E; F]
<Instruct>: Given the context 'Samples evaluated for CD4+ and CD8α+ cells were also incubated with biotin-conjugated hamster anti-mouse CD3e (145-2C11) monoclonal antibody (BD Pharmingen, San Diego, CA) and subsequently with streptavidin APC Cy7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mouse (aka mus musculus) B: mus musculoides (mus musculoides enclavae) (aka mus musculoides) C: peromyscus D: mus domesticus (aka mus musculus domesticus) E: mus <genus> (mice (aka mus <genus>)) F: None of the above.
[A]
<Instruct>: Given the context 'Samples evaluated for CD4+ and CD8α+ cells were also incubated with biotin-conjugated hamster anti-mouse CD3e (145-2C11) monoclonal antibody (BD Pharmingen, San Diego, CA) and subsequently with streptavidin APC Cy7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: mus musculoides (mus musculoides enclavae) (aka mus musculoides) B: mus domesticus (aka mus musculus domesticus) C: peromyscus D: mus <genus> (mice (aka mus <genus>)) E: None of the above.
[E]
<Instruct>: Given the context 'Antibody assays Immunoglobulin subclass IgG1 and IgG2a titers in mice were determined by a whole bacterial cell ELISA performed in 96-well, Immulon 2 HB, round-bottom plates (Dynex Technologies).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mice] <Options>: A: mus domesticus (aka mus musculus domesticus) B: mus <subgenus> (mus (aka mus <subgenus>)) C: peromyscus D: mus castaneus (aka mus musculus castaneus) E: mus musculus (house mouse) (aka mus musculus) F: None of the above.
[E]
<Instruct>: Given the context 'B. mallei antigen was diluted in 0.1 M carbonate buffer (pH 9.5) and 50 μl of diluted cells placed into wells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [b. mallei] <Options>: A: mallomonas peronoides (aka mallomonas peroneides) B: malleomyces pseudomallei (aka burkholderia pseudomallei) C: malleco D: pfeifferella mallei (aka burkholderia mallei) E: mallocybe (inocybe subg. mallocybe) (aka mallocybe) F: None of the above.
[D]
<Instruct>: Given the context 'The plates were washed with washing solution (1× PBS, 0.05% Tween 20), and incubated with 100 μl of blocking solution (1× PBS, 1% bovine serum albumin, 0.05% Tween 20) for 1 h at 37°C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [bovine] <Options>: A: bos bubalis bubalis (aka bubalus bubalis bubalis) B: domestic cattle (aka bos taurus) C: boveria D: bos sp. E: bovidae F: None of the above.
[B]
<Instruct>: Given the context 'Dilutions of mouse sera were made with blocking solution in duplicate and plates were incubated for 1 h at 37°C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [mouse] <Options>: A: house mouse (aka mus musculus) B: mus musculoides (mus musculoides enclavae) (aka mus musculoides) C: mus (aka mus <subgenus>) (aka mus <subgenus>) D: eastern european house mouse (aka mus musculus musculus) E: mice (aka mus sp.) (aka mus sp.) F: None of the above.
[A]
<Instruct>: Given the context 'Following incubation, plates were washed and 50 μl of anti-Ig-horseradish peroxidase subclass conjugate, diluted accordingly to manufacturer's instructions (Southern Biotechnology Associates, Inc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [horseradish] <Options>: A: horseradish (aka armoracia rusticana) B: rosa arabica C: horseradish tree (aka moringa oleifera) D: rosa hugonis (rosa xanthina f. hugonis) (aka rosa hugonis) E: rachis F: None of the above.
[A]
<Instruct>: Given the context 'Mapping irradiation hybrids to cosmid and yeast artificial chromosome libraries by direct hybridization of Alu-PCR products. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [yeast] <Options>: A: saccharomyces cerevisiae (saccharomyces cerevisiae (desm.) meyen ex e.c. hansen, 1883) (aka saccharomyces cerevisiae) B: saccharomycetes (hemiascomycetes) (aka saccharomycetes) C: saccharomyces lactis (aka kluyveromyces lactis) D: saccharomyces albicans (aka candida albicans) E: saccharomyces cerevisiae x saccharomyces mikatae F: None of the above.
[A]
<Instruct>: Given the context 'Abstract A direct hybridization protocol is described for screening cosmid and yeast artificial chromosome libraries with pools of Alu-PCR products from somatic cell or irradiation hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [yeast] <Options>: A: saccharomyces cf. cerevisiae/paradoxus (saccharomyces cerevisiae or paradoxus) (aka saccharomyces cf. cerevisiae/paradoxus) B: budding yeasts & others (aka saccharomycotina) C: saccharomyceta D: saccharomyces albicans (aka candida albicans) E: saccharomyces cerevisiae (desm.) meyen ex e.c. hansen, 1883 (aka saccharomyces cerevisiae) F: None of the above.
[E]
<Instruct>: Given the context 'A series of human X chromosome irradiation hybrids were mapped by this method, using a cosmid reference library for comparisons between overlapping hybrids to identify interesting clones for further analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [human] <Options>: A: homo (humans) (aka homo) B: human (aka homo sapiens) C: this D: kingdom E: animals (aka metazoa) F: None of the above.
[B]
<Instruct>: Given the context 'Images Nucleic Acids Research, Vol. 19, No. 12 3315 Mapping irradiation hybrids to cosmid and yeast artificial chromosome libraries by direct hybridization of Alu-PCR products Anthony P.Monaco*, Veronica M.S.Lam2, Gunther Zehetner, Gregory G.Lennon, Christal Douglas, Dean Nizetic, Peter N.Goodfellow1 and Hans Lehrach Genome Analysis Laboratory and 'Molecular Human Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK and 2Department of Biochemistry, Li Shu Fan Building, Sassoon Road, University of Hong Kong, Hong Kong Received March 12, 1991; Revised and Accepted May 16, 1991 ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [yeast] <Options>: A: saccharomyces sp. B: saccharomyces lactis (aka kluyveromyces lactis) C: saccharomyceta D: saccharomycetes (hemiascomycetes) (aka saccharomycetes) E: mycoderma cerevisiae (aka saccharomyces cerevisiae) F: None of the above.
[E]
<Instruct>: Given the context 'ABSTRACT A direct hybridization protocol is described for screening cosmid and yeast artificial chromosome libraries with pools of Alu-PCR products from somatic cell or irradiation hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [yeast] <Options>: A: saccharomyces cerevisiae x saccharomyces mikatae B: saccharomyces sp. C: saccharomycetes (hemiascomycetes) (aka saccharomycetes) D: saccharomyces cf. cerevisiae E: baker's yeast (aka saccharomyces cerevisiae) F: None of the above.
[E]
<Instruct>: Given the context 'ABSTRACT A direct hybridization protocol is described for screening cosmid and yeast artificial chromosome libraries with pools of Alu-PCR products from somatic cell or irradiation hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [yeast] <Options>: A: saccharomyces sp. B: saccharomycetes (hemiascomycetes) (aka saccharomycetes) C: saccharomyces cerevisiae x saccharomyces mikatae D: saccharomyces cf. cerevisiae E: None of the above.
[E]
<Instruct>: Given the context 'A series of human X chromosome irradiation hybrids were mapped by this method, using a cosmid reference library for comparisons between overlapping hybrids to identify interesting clones for further analysis. ', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [human] <Options>: A: primate (aka primates) B: eutherian mammals (aka eutheria) C: mammals (aka mammalia) D: species E: homo sapiens (human) (aka homo sapiens) F: None of the above.
[E]
<Instruct>: Given the context 'INTRODUCTION The generation of human DNA probes specific for individual chromosomes and subregions of chromosomes has been advanced with Alu-sequence primed polymerase chain reaction amplification (Alu-PCR, 1-3).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon.
<Mentions>: [human] <Options>: A: primate (aka primates) B: macrobiotus sapiens C: genus D: human (aka homo sapiens) E: probles F: None of the above.
[D]