question_id stringlengths 1 4 | question stringlengths 26 249 | pos_item_ids listlengths 1 5 | pos_item_contents listlengths 1 5 |
|---|---|---|---|
822 | N348I mutations cause resistance to nevirapine. | [
"15319019"
] | [
"N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance. Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. ... |
825 | N348I mutations reduce resistance to nevirapine. | [
"15319019"
] | [
"N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance. Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. ... |
826 | NAC destabilizes NO to increase the effect of contrast agents on renal functions. | [
"4678846"
] | [
"Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.. CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography sca... |
828 | NAC inhibits the generation of angiotensin-converting enzyme. | [
"4678846"
] | [
"Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.. CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography sca... |
835 | NR5A2 does not play a role in development of endometrial tissues. | [
"15928989"
] | [
"Liver receptor homolog-1 is essential for pregnancy. Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in gr... |
838 | NR5A2 is important in reverse cholesterol transport in humans. | [
"15928989"
] | [
"Liver receptor homolog-1 is essential for pregnancy. Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in gr... |
840 | Natriuretic peptides increase susceptibility to diabetes. | [
"15663829"
] | [
"Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies. BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but th... |
841 | Natriuretic peptides protect against diabetes. | [
"15663829"
] | [
"Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies. BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but th... |
844 | Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO. | [
"17741440"
] | [
"Netting neutrophils in autoimmune small-vessel vasculitis. Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophil... |
846 | Neutrophils produce IL-1β in response to large particles. | [
"22696649"
] | [
"Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size. How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive ox... |
848 | Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States. | [
"14500725"
] | [
"Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile. BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SS... |
85 | Adult tissue-resident macrophages are seeded before birth. | [
"7521113",
"22406695"
] | [
"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manip... |
853 | Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos. | [
"24922825"
] | [
"A chikungunya fever vaccine utilizing an insect-specific virus platform. Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inabi... |
854 | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime. | [
"12206390"
] | [
"Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.. CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown. OBJECTIVES To esti... |
855 | Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation. | [
"8190282"
] | [
"Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial.. CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure. OBJECTIVE To c... |
856 | Nonsteroidal antinflammatory drugs are ineffective as cancer treatments. | [
"43334921"
] | [
"Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.. IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit... |
857 | Nonsteroidal antinflammatory drugs show potential anticancer indications. | [
"43334921"
] | [
"Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.. IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit... |
858 | Normal expression of RUNX1 causes tumorsupressing effects. | [
"1982286"
] | [
"Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to de... |
86 | Adult tissue-resident macrophages are seeded before birth. | [
"7521113",
"22406695"
] | [
"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manip... |
860 | Normal granulomas form in the absence of TNF in Zebrafish. | [
"16066726"
] | [
"Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.. Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immun... |
861 | Normal granulomas form in the presence of TNF in Zebrafish. | [
"16066726"
] | [
"Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.. Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immun... |
863 | Notch signaling occurs between tumor cells and stromal cells. | [
"20568364",
"16361581"
] | [
"Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.. While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regarding contact-dependent signals that promote tumor angio... |
866 | Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells. | [
"37822406"
] | [
"Human somatic cell nuclear transfer using adult cells.. Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus f... |
867 | Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa. | [
"14340571"
] | [
"The Molecular Basis for Oat Intolerance in Patients with Celiac Disease. Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inappropriate immune response to dietary gluten and is trea... |
871 | Obesity decreases life quality. | [
"195689316"
] | [
"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.. BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective ... |
876 | Obesity raises life quality. | [
"195689316"
] | [
"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.. BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective ... |
877 | Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain. | [
"313394"
] | [
"A Functional Neuroimaging Study of Sound Localization: Visual Cortex Activity Predicts Performance in Early-Blind Individuals. Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earli... |
88 | Adult tissue-resident macrophages possess a self-renewing capacity. | [
"7521113",
"22406695"
] | [
"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manip... |
881 | Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans. | [
"14803797"
] | [
"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that met... |
883 | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans. | [
"14803797"
] | [
"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that met... |
884 | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians. | [
"14803797"
] | [
"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that met... |
885 | One in five surgical randomized controlled trials are discontinued early. | [
"6477536"
] | [
"Discontinuation and non-publication of surgical randomised controlled trials: observational study. OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. DESIGN Cross sectional observational study of registered and publish... |
886 | One in two surgical randomized controlled trials are discontinued early. | [
"6477536"
] | [
"Discontinuation and non-publication of surgical randomised controlled trials: observational study. OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. DESIGN Cross sectional observational study of registered and publish... |
89 | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver. | [
"7521113",
"22406695"
] | [
"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manip... |
890 | Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
"2097256"
] | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... |
891 | Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
"2097256"
] | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... |
893 | Osteocytes have an essential role in G-CSF induced HSPC mobilization. | [
"13509809"
] | [
"Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.. The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we demonstrate that osteocytes, the major cellular co... |
894 | Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia. | [
"14724693"
] | [
"Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.. CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the adult population. Although glucosamine is increasingl... |
895 | Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. | [
"18750453"
] | [
"Assessment of Volume Depletion in Children with Malaria. Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compar... |
896 | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139. | [
"14338915"
] | [
"Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin. The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to hum... |
897 | Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139. | [
"14338915"
] | [
"Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin. The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to hum... |
898 | Oxidative DNA damage activates STING signalling. | [
"13106686",
"5572127"
] | [
"Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.. Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement ... |
899 | Oxidative DNA damage inhibits STING signalling. | [
"13106686",
"5572127"
] | [
"Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.. Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement ... |
9 | 32% of liver transplantation programs required patients to discontinue methadone treatment in 2001. | [
"44265107"
] | [
"Liver transplantation and opioid dependence.. ContextChronic hepatitis C is the leading cause for liver transplantation in the United States. Intravenous drug use, the major risk factor, accounts for approximately 60% of hepatitis C virus transmission. Information from the United Network of Organ Sharing (UNOS) do... |
90 | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver. | [
"22406695"
] | [
"Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its o... |
900 | Oxidative phosphorylation is one of the primary glycometabolic pathways in cells. | [
"18678095"
] | [
"Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport. Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for the FAT of vesicles. Although inhibiting ATP production from mito... |
901 | PCSK9 inhibitors decrease plasma Lp(a) levels. | [
"6540064"
] | [
"Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells ... |
902 | PD-1 triggering on monocytes enhances IL-10 production by monocytes. | [
"10648422"
] | [
"Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infe... |
908 | PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. | [
"6923961"
] | [
"Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remai... |
909 | PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice. | [
"11254556"
] | [
"Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger... |
91 | Aged patients are less susceptible to ischaemia/reperfusion injury. | [
"1084345"
] | [
"Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems... |
910 | PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice. | [
"11254556"
] | [
"Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger... |
912 | PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice. | [
"11254556"
] | [
"Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger... |
916 | PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients. | [
"18037805"
] | [
"Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro. The transcriptional status of a gene can be maintained through multiple rounds of cell division during development. This epigenetic effect is believed to reflect heritable changes in chromatin folding and histone modifications or ... |
917 | PTEN is a regulator for the transcriptional activity of SRF | [
"34071621"
] | [
"Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function. SMC contractile gene expression and, thus differentiation, is under d... |
919 | Participants who quit smoking reduce lung cancer risk by approximately 50%. | [
"16422880"
] | [
"Effect of smoking reduction on lung cancer risk.. CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not clear whether this strategy decreases the risk for tobacco-related diseases. OBJECTI... |
92 | Aged patients are more susceptible to ischaemia/reperfusion injury. | [
"1084345"
] | [
"Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems... |
923 | Patients in stable partnerships have a slower progression from HIV to AIDS. | [
"17077004"
] | [
"Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAAR... |
925 | Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships. | [
"17077004"
] | [
"Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAAR... |
926 | Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | [
"16390264"
] | [
"Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics. OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by... |
927 | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | [
"16390264"
] | [
"Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics. OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by... |
928 | Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum. | [
"18174210"
] | [
"Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygou... |
929 | Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum. | [
"18174210"
] | [
"Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygou... |
93 | Aggravated inflammation is dependent on NLRP3 inflammasome activation. | [
"2692522"
] | [
"Gout-associated uric acid crystals activate the NALP3 inflammasome. Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tis... |
930 | Patients with panic anxiety show decreased CSF levels of hypocretin. | [
"16056514"
] | [
"A KEY ROLE FOR OREXIN IN PANIC ANXIETY. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after ... |
933 | Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours. | [
"14711483"
] | [
"Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.. CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric oxide-dependent regulation of vascular tone, adhesion, p... |
934 | Perigenital skin is not the primary site of HIV acquisition. | [
"8563659"
] | [
"Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies o... |
935 | Peroxynitrite is required for induction of T cell tolerance. | [
"5483793"
] | [
"Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptid... |
938 | Persister cells provide relapse resistance in cancer patients. | [
"26231129"
] | [
"A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers... |
939 | Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients. | [
"26231129"
] | [
"A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers... |
940 | Pharmacist attendance at ward rounds increases adverse events in wards. | [
"12258338"
] | [
"Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the IC... |
941 | Pharmacist attendance at ward rounds reduces adverse events in wards. | [
"12258338"
] | [
"Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the IC... |
942 | Phase information is useful for predicting donor-recipient matches in organ transplantation. | [
"11527199"
] | [
"MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation. Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus within the major histocompatibility complex (MHC). Gr... |
944 | Physical activity does not improve cognitive function in individuals with Alzheimers. | [
"1642727"
] | [
"Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.. CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. OBJECTIVE To determine whether physi... |
945 | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | [
"8428935",
"26112696",
"4463588",
"13083189"
] | [
"Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.. CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different... |
946 | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | [
"8428935",
"26112696",
"4463588",
"13083189"
] | [
"Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.. CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different... |
949 | Physical injury represses transgultaminase activity. | [
"13578199"
] | [
"Transglutaminase 2 Undergoes a Large Conformational Change upon Activation . Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of ... |
95 | Albendazole is used to treat soil-transmitted helminths. | [
"1215116"
] | [
"“Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor. Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive red... |
951 | Piezo1 channels are sensors for cell migration in epithelial cells. | [
"21414718"
] | [
"Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro. Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we screened Piezo1 as a candidate TFF1-binding protein. We ai... |
952 | Pioglitazone use is not associated with an increased risk of prostate cancer. | [
"3355397"
] | [
"Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.. IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PAR... |
953 | Pioglitazone use is significantly associated with an increased risk of pancreatic cancer. | [
"3355397"
] | [
"Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.. IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PAR... |
954 | Pioglitazone use is significantly associated with an increased risk of prostate cancer. | [
"3355397"
] | [
"Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.. IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PAR... |
955 | Pioneer factor OCT3/4 interacts with major chromatin remodeling factors. | [
"2078658",
"30507607"
] | [
"Oct4 links multiple epigenetic pathways to the pluripotency network. Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic pro... |
959 | Polymeal nutrition increases cardiovascular mortality. | [
"8780599"
] | [
"The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.. OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its... |
96 | Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States. | [
"14500725"
] | [
"Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile. BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SS... |
962 | Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules. | [
"13931771",
"935538",
"4306711"
] | [
"GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules. Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported ... |
963 | Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates. | [
"4162857",
"29828242"
] | [
"Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns. RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate tha... |
964 | Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates. | [
"4162857",
"29828242"
] | [
"Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns. RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate tha... |
965 | Prescribed exercise training improves quality of life. | [
"40817021"
] | [
"Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.. CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. OBJECTIVE To test the effects of exercise training on he... |
969 | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication. | [
"19356271",
"17368516"
] | [
"hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.. Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously unrecognized prim-pol in human cells, which we designate... |
970 | PrimPol generates short DNA replication intermediates on the leading strand during DNA replication. | [
"19356271",
"17368516"
] | [
"hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.. Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously unrecognized prim-pol in human cells, which we designate... |
972 | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | [
"46695481",
"27873158",
"28617573",
"9764256"
] | [
"Human papillomavirus and Papanicolaou tests to screen for cervical cancer.. BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis... |
973 | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | [
"27446873",
"27873158",
"28617573",
"9764256"
] | [
"Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.. OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage co... |
976 | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators. | [
"5304891"
] | [
"Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine th... |
977 | Pro-inflammatory cytokines are up regulated during tumor development. | [
"14075252",
"39264456"
] | [
"Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interaction... |
978 | Pro-inflammatory cytokines are up repressed during tumor development. | [
"14075252"
] | [
"Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interaction... |
979 | Progerin induces premature aging in stem cells. | [
"11659421"
] | [
"Human iPSC-based modeling of late-onset disease via progerin-induced aging.. Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for ind... |
98 | Alirocumab treatment reduces apo(a) fractional clearance rate. | [
"6540064"
] | [
"Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells ... |
980 | Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury. | [
"20128547"
] | [
"Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontaneous functional recovery during the first months after injury. Such recovery is widel... |
984 | Pseudogene PTENP1 encodes a transcript that regulates PTEN expression. | [
"6828370"
] | [
"A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies o... |
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