Subset (2)

scifact_data · 1.11k rows

Split (2)

train · 809 rows

question_id stringlengths 1 4	question stringlengths 26 249	pos_item_ids listlengths 1 5	pos_item_contents listlengths 1 5
67	Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.	[ "21295300" ]	[ "Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death. The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM c...
670	Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.	[ "5573975" ]	[ "Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis. Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that...
671	Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.	[ "5573975" ]	[ "Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis. Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that...
672	L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.	[ "15635366" ]	[ "The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.. L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbt...
673	LDL cholesterol has a causal role in the development of cardiovascular disease.	[ "2095573" ]	[ "LDL-cholesterol concentrations: a genome-wide association study. BACKGROUND LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic tar...
676	LRBA prevents CTLA - 4 recycling.	[ "857189" ]	[ "Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family in which five individuals presented with a complex...
677	LRBA promotes CTLA - 4 recycling.	[ "857189" ]	[ "Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family in which five individuals presented with a complex...
679	LSD1-positive promoters are associated with RNA polymerase II	[ "13639330" ]	[ "Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors. Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impos...
68	Activated Cdk5 regulates DNA damage-induced neuronal death.	[ "21295300" ]	[ "Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death. The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM c...
680	Lack of FGF21 in mice increases life expectancy.	[ "9315213" ]	[ "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It...
681	Lack of FGF21 in mice leads to atherosclerotic plaque formation.	[ "9315213" ]	[ "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It...
682	Lack of FGF21 in mice leads to reduced lifespan.	[ "9315213" ]	[ "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It...
683	Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.	[ "9315213" ]	[ "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It...
685	Lamins are associated with nuclear membrane structure maintenance.	[ "4452659" ]	[ "Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic mat...
686	Lamins are found within the inner layer of the mitochondrial membrane of all cells.	[ "4452659" ]	[ "Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic mat...
687	Lamins are found within the inner layer of the nuclear membrane of all cells.	[ "4452659" ]	[ "Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic mat...
688	Lamins have no effect on nuclear membrane structure maintenance.	[ "4452659" ]	[ "Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic mat...
689	Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.	[ "22080671" ]	[ "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods ...
69	Activation of PPM1D enhances p53 function.	[ "5956380", "4414547" ]	[ "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem ...
694	Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.	[ "1071991" ]	[ "Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate models of HIV and AIDS, yet the basis of their robust protection remains poorly understood. Here we s...
696	Lipopolysaccharides have an inflammation independent effect on kidney barrier function.	[ "16355392" ]	[ "Modification of kidney barrier function by the urokinase receptor. Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction ...
698	Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).	[ "22544171" ]	[ "Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian ce...
703	Localization of PIN1 in the roots of Arabidopsis requires VPS9a	[ "4350400" ]	[ "Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions. Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication—a vital feature of multicellular development. Efflux carriers for the signalling mo...
704	Long - range chromatin interactions regulate transcription.	[ "14658685" ]	[ "Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian s...
705	Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.	[ "22442133" ]	[ "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergi...
709	Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.	[ "22442133" ]	[ "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergi...
71	Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.	[ "1127562" ]	[ "Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clea...
710	Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.	[ "22442133" ]	[ "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergi...
713	Low expression of miR7a does not repress target genes or exert a biological function in ovaries.	[ "18421962" ]	[ "Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the acti...
714	Low expression of miR7a does not repress target genes or exert a biological function in testis.	[ "18421962" ]	[ "Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the acti...
717	Low nucleosome occupancy correlates with high methylation levels across species.	[ "17587795" ]	[ "Dnmt1-Independent CG Methylation Contributes to Nucleosome Positioning in Diverse Eukaryotes. Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively surve...
724	Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.	[ "5531479" ]	[ "The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.. Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swif...
726	Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.	[ "7521113", "36444198" ]	[ "Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manip...
73	Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.	[ "6076903" ]	[ "Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field. Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We discovered that quadruple knockdown of ADMP and BM...
730	Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.	[ "13400643" ]	[ "A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling pathways simultaneously. Here, using an innovative cell-ba...
732	M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.	[ "34469966" ]	[ "Human Monocytes Engage an Alternative Inflammasome Pathway.. Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this c...
733	M. stadtmanae induces ASC speck formation in BlaER1 monocytes.	[ "34469966" ]	[ "Human Monocytes Engage an Alternative Inflammasome Pathway.. Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this c...
734	MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.	[ "4961038" ]	[ "Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers. Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They are most frequently observed in two hotspots: the helical do...
736	MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.	[ "5389095" ]	[ "Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased...
737	MICAL redox enzymes regulate actin dynamics in many cell types.	[ "16562534", "6609935" ]	[ "Drosophila MICAL regulates myofilament organization and synaptic structure. The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we d...
738	MICAL redox enzymes regulate actin dynamics.	[ "16562534", "6609935", "33912020" ]	[ "Drosophila MICAL regulates myofilament organization and synaptic structure. The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we d...
739	MT binding domain drives amyloid structure formation.	[ "4446814" ]	[ "Cryo-EM structures of Tau filaments from Alzheimer’s disease brain. Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary l...
74	Active H. pylori urease has a polymeric structure consisting of five distinct subunits.	[ "4387784" ]	[ "Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori. Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is es...
740	MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.	[ "23078022" ]	[ "MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling. Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-κB, blocks...
745	MafA phosphorylation decreases its ubiquitination.	[ "11291348" ]	[ "GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-...
746	MafA phosphorylation enhances its ubiquitination.	[ "11291348" ]	[ "GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-...
747	MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.	[ "11291348" ]	[ "GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-...
748	MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.	[ "11291348" ]	[ "GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-...
749	Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.	[ "13868795" ]	[ "CD28 Costimulation: From Mechanism to Therapy.. Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a key role in many...
751	Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).	[ "19800147" ]	[ "MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine differen...
752	Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.	[ "19800147" ]	[ "MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine differen...
753	Malaria has a high vectorial capacity.	[ "1173667" ]	[ "Ranking of elimination feasibility between malaria-endemic countries. Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for...
755	Many cytokines that are produced by cancer cells also contribute to carcinogenesis.	[ "17844478" ]	[ "Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development. It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for t...
757	Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.	[ "17123657" ]	[ "Dynamic Helix Interactions in Transmembrane Signaling. Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of ...
758	Marmosets have a brain region homologous to Broca's area.	[ "14195528" ]	[ "Responses of primate frontal cortex neurons during natural vocal communication.. The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization processing occurs in ventrolateral prefrontal cortex neurons...
76	Active Ly49Q induces neutrophil polarization.	[ "5531479" ]	[ "The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.. Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swif...
760	Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.	[ "1805641" ]	[ "Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity. BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to re...
761	MeCP2 influences the synaptic maturation of neurons.	[ "10009203" ]	[ "Structural Homeostasis: Compensatory Adjustments of Dendritic Arbor Geometry in Response to Variations of Synaptic Input . As the nervous system develops, there is an inherent variability in the connections formed between differentiating neurons. Despite this variability, neural circuits form that are functional a...
762	Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.	[ "4695046" ]	[ "Anxiety. OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controlled Trials Register, and hand searches of key journals. MET...
764	Medications to treat obesity are highly effective.	[ "7552215" ]	[ "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register,...
765	Medications to treat obesity do not have side effects.	[ "7552215" ]	[ "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register,...
766	Medications to treat obesity have unwanted side effects.	[ "7552215" ]	[ "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register,...
767	Men are more susceptible to death due to pneumonia when compared to women.	[ "2488880" ]	[ "Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.. CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. OBJECTIVE To investigate the role of gender among ...
77	Active Ly49Q prevents neutrophil polarization.	[ "5531479" ]	[ "The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.. Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swif...
771	Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.	[ "15476777" ]	[ "Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate redu...
772	Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.	[ "24922825" ]	[ "A chikungunya fever vaccine utilizing an insect-specific virus platform. Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inabi...
774	Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).	[ "32275758" ]	[ "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and f...
776	Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).	[ "32275758" ]	[ "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and f...
777	Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).	[ "32275758" ]	[ "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and f...
778	Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.	[ "13001323" ]	[ "SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.. Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical ...
779	Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.	[ "13001323" ]	[ "SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.. Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical ...
78	Active caspase-11 participate in regulating phagosome-lysosome fusion.	[ "5099266" ]	[ "Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.. Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sense...
780	Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.	[ "8246922", "24338780" ]	[ "the Development of Autoimmune Myocarditis in Mice by an. BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and ...
782	Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.	[ "8246922" ]	[ "the Development of Autoimmune Myocarditis in Mice by an. BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and ...
787	Microcin J25 encourages nucleoside triphosphate (NTP) binding.	[ "4740447" ]	[ "Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.. The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indicate that inhibition of transcription occurs at the l...
788	Microcin J25 inhibits nucleoside triphosphate (NTP) binding.	[ "4740447" ]	[ "Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.. The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indicate that inhibition of transcription occurs at the l...
789	Microglia are an innate immune cell type of the central nervous system.	[ "15493354" ]	[ "Sublime Microglia: Expanding Roles for the Guardians of the CNS. Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt ...
79	Active caspase-11 protein promotes pyroptosis.	[ "5099266" ]	[ "Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.. Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sense...
790	Microglia are an innate immune cell type of the peripheral nervous system.	[ "15493354" ]	[ "Sublime Microglia: Expanding Roles for the Guardians of the CNS. Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt ...
791	Migraine with aura is associated with ischemic stroke.	[ "15984735" ]	[ "Migraine and cardiovascular disease: systematic review and meta-analysis.. OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databas...
792	Misunderstandings between doctors and patients can lead to non-adherence.	[ "3610080" ]	[ "Misunderstandings in prescribing decisions in general practice: qualitative study.. OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. DESIGN Qualitative study. SETTING 20 general practices in the West Midlands and south eas...
795	Mitochondria play a major role in apoptosis.	[ "8551160" ]	[ "Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitocho...
797	Mitochondria play a major role in energy production.	[ "8551160" ]	[ "Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitocho...
798	Mitochondria play a trivial role in calcium homeostasis.	[ "8551160" ]	[ "Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitocho...
799	Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).	[ "5293024" ]	[ "Life is sweet: candy consumption and longevity.. Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however, clinical trials have not supported this.1 Candy—sug...
80	Acute ablation of KRAS causes severe growth impairment.	[ "4920376" ]	[ "Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.. Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhi...
801	Monoclonal antibody targeting of N-cadherin encourages castration resistance.	[ "22180793" ]	[ "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CR...
802	Monoclonal antibody targeting of N-cadherin encourages metastasis.	[ "22180793" ]	[ "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CR...
803	Monoclonal antibody targeting of N-cadherin inhibits castration resistance.	[ "22180793" ]	[ "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CR...
804	Monoclonal antibody targeting of N-cadherin inhibits growth.	[ "22180793" ]	[ "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CR...
807	Most termination events in Okazaki fragments are dictated by initiation patterns.	[ "36606083" ]	[ "Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.. Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork progression is influenced by transcription, are poorly un...
81	Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.	[ "1797622" ]	[ "Control of Apoptosis by Asymmetric Cell Division. Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functional...
810	Mouse models can be generated using "artificial spermatids."	[ "13513790" ]	[ "Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, s...
812	Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.	[ "19799455" ]	[ "Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize coll...
813	Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.	[ "33387953" ]	[ "Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance. Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ pr...
815	Mutations in RIM1 decrease levels of IME1 RNA.	[ "8148304" ]	[ "Molecular characterization of the yeast meiotic regulatory gene RIM1.. In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to...
816	Mutations in RIM1 raise levels of IME1 RNA.	[ "8148304" ]	[ "Molecular characterization of the yeast meiotic regulatory gene RIM1.. In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to...
817	Myelin sheaths are lipid-rich cellular structures.	[ "17814815" ]	[ "Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based ...
818	Myelin sheaths play a role in action potential propagation.	[ "17814815" ]	[ "Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based ...
82	Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)	[ "3619372" ]	[ "Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.. Stem cell-based approaches to cardiac regeneration are increasingly viable strategies for treating heart failure. Generating abundant and functional autologous cells for transplantation in such a setting, however, remains a significant chal...

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